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Database: PDB
Entry: 6OAA
LinkDB: 6OAA
Original site: 6OAA 
HEADER    MOTOR PROTEIN                           15-MAR-19   6OAA              
TITLE     CDC48-NPL4 COMPLEX PROCESSING POLY-UBIQUITINATED SUBSTRATE IN THE     
TITLE    2 PRESENCE OF ADP-BEFX, STATE 1                                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CELL DIVISION CONTROL PROTEIN 48;                          
COMPND   3 CHAIN: B, C, D, E;                                                   
COMPND   4 SYNONYM: CELL DIVISION CYCLE PROTEIN 48, TRANSITIONAL ENDOPLASMIC    
COMPND   5 RETICULUM ATPASE HOMOLOG, CDC48;                                     
COMPND   6 EC: 3.6.4.6;                                                         
COMPND   7 ENGINEERED: YES;                                                     
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: NUCLEAR PROTEIN LOCALIZATION PROTEIN 4;                    
COMPND  10 CHAIN: G;                                                            
COMPND  11 SYNONYM: HMG-COA REDUCTASE DEGRADATION PROTEIN 4, NPL4;              
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: UBIQUITIN;                                                 
COMPND  15 CHAIN: H;                                                            
COMPND  16 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE S288C;                 
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 GENE: CDC48, YDL126C;                                                
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  10 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  11 ORGANISM_TAXID: 4932;                                                
SOURCE  12 GENE: NPL4, HRD4, YBR170C, YBR1231;                                  
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  17 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  18 ORGANISM_TAXID: 4932;                                                
SOURCE  19 GENE: RPL40A, UBI1, YIL148W;                                         
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    ATPASE, ATPASE COMPLEX, UBIQUITIN, QUALITY CONTROL, MOTOR PROTEIN     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    E.C.TWOMEY,Z.JI,T.E.WALES,N.O.BODNAR,J.R.ENGEN,T.A.RAPOPORT           
REVDAT   4   20-NOV-19 6OAA    1       REMARK                                   
REVDAT   3   14-AUG-19 6OAA    1       JRNL                                     
REVDAT   2   10-JUL-19 6OAA    1       JRNL                                     
REVDAT   1   03-JUL-19 6OAA    0                                                
JRNL        AUTH   E.C.TWOMEY,Z.JI,T.E.WALES,N.O.BODNAR,S.B.FICARRO,J.A.MARTO,  
JRNL        AUTH 2 J.R.ENGEN,T.A.RAPOPORT                                       
JRNL        TITL   SUBSTRATE PROCESSING BY THE CDC48 ATPASE COMPLEX IS          
JRNL        TITL 2 INITIATED BY UBIQUITIN UNFOLDING.                            
JRNL        REF    SCIENCE                       V. 365       2019              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   31249135                                                     
JRNL        DOI    10.1126/SCIENCE.AAX1033                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.10 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : SERIALEM, CRYOSPARC                       
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.100                          
REMARK   3   NUMBER OF PARTICLES               : 30118                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6OAA COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-MAR-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000240220.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CDC48-NPL4 COMPLEX PROCESSING     
REMARK 245                                    POLY-UBIQUITINATED SUBSTRATE IN   
REMARK 245                                    THE PRESENCE OF ADP-BEFX, STATE   
REMARK 245                                    1                                 
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : WAITED 20 SECONDS BEFORE          
REMARK 245                                    BLOTTING FOR 2.5-3 SECONDS.       
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TALOS ARCTICA              
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 44.70                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, C, D, E, G, H                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     GLU B     4                                                      
REMARK 465     HIS B     5                                                      
REMARK 465     LYS B     6                                                      
REMARK 465     PRO B     7                                                      
REMARK 465     LEU B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     ASP B    10                                                      
REMARK 465     ALA B    11                                                      
REMARK 465     SER B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     VAL B    14                                                      
REMARK 465     ASP B    15                                                      
REMARK 465     PRO B    16                                                      
REMARK 465     ARG B    17                                                      
REMARK 465     GLU B    18                                                      
REMARK 465     GLU B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     LYS B    21                                                      
REMARK 465     THR B    22                                                      
REMARK 465     ALA B    23                                                      
REMARK 465     THR B    24                                                      
REMARK 465     ALA B    25                                                      
REMARK 465     ILE B    26                                                      
REMARK 465     LEU B    27                                                      
REMARK 465     ARG B    28                                                      
REMARK 465     ARG B    29                                                      
REMARK 465     LYS B    30                                                      
REMARK 465     LYS B    31                                                      
REMARK 465     LYS B    32                                                      
REMARK 465     ASP B    33                                                      
REMARK 465     ASN B    34                                                      
REMARK 465     MET B    35                                                      
REMARK 465     LEU B    36                                                      
REMARK 465     LEU B    37                                                      
REMARK 465     VAL B    38                                                      
REMARK 465     ASP B    39                                                      
REMARK 465     ASP B    40                                                      
REMARK 465     ALA B    41                                                      
REMARK 465     ILE B    42                                                      
REMARK 465     ASN B    43                                                      
REMARK 465     ASP B    44                                                      
REMARK 465     ASP B    45                                                      
REMARK 465     ASN B    46                                                      
REMARK 465     SER B    47                                                      
REMARK 465     VAL B    48                                                      
REMARK 465     ILE B    49                                                      
REMARK 465     ALA B    50                                                      
REMARK 465     ILE B    51                                                      
REMARK 465     ASN B    52                                                      
REMARK 465     SER B    53                                                      
REMARK 465     ASN B    54                                                      
REMARK 465     THR B    55                                                      
REMARK 465     MET B    56                                                      
REMARK 465     ASP B    57                                                      
REMARK 465     LYS B    58                                                      
REMARK 465     LEU B    59                                                      
REMARK 465     GLU B    60                                                      
REMARK 465     LEU B    61                                                      
REMARK 465     PHE B    62                                                      
REMARK 465     ARG B    63                                                      
REMARK 465     GLY B    64                                                      
REMARK 465     ASP B    65                                                      
REMARK 465     THR B    66                                                      
REMARK 465     VAL B    67                                                      
REMARK 465     LEU B    68                                                      
REMARK 465     VAL B    69                                                      
REMARK 465     LYS B    70                                                      
REMARK 465     GLY B    71                                                      
REMARK 465     LYS B    72                                                      
REMARK 465     LYS B    73                                                      
REMARK 465     ARG B    74                                                      
REMARK 465     LYS B    75                                                      
REMARK 465     ASP B    76                                                      
REMARK 465     THR B    77                                                      
REMARK 465     VAL B    78                                                      
REMARK 465     LEU B    79                                                      
REMARK 465     ILE B    80                                                      
REMARK 465     VAL B    81                                                      
REMARK 465     LEU B    82                                                      
REMARK 465     ILE B    83                                                      
REMARK 465     ASP B    84                                                      
REMARK 465     ASP B    85                                                      
REMARK 465     GLU B    86                                                      
REMARK 465     LEU B    87                                                      
REMARK 465     GLU B    88                                                      
REMARK 465     ASP B    89                                                      
REMARK 465     GLY B    90                                                      
REMARK 465     ALA B    91                                                      
REMARK 465     CYS B    92                                                      
REMARK 465     ARG B    93                                                      
REMARK 465     ILE B    94                                                      
REMARK 465     ASN B    95                                                      
REMARK 465     ARG B    96                                                      
REMARK 465     VAL B    97                                                      
REMARK 465     VAL B    98                                                      
REMARK 465     ARG B    99                                                      
REMARK 465     ASN B   100                                                      
REMARK 465     ASN B   101                                                      
REMARK 465     LEU B   102                                                      
REMARK 465     ARG B   103                                                      
REMARK 465     ILE B   104                                                      
REMARK 465     ARG B   105                                                      
REMARK 465     LEU B   106                                                      
REMARK 465     GLY B   107                                                      
REMARK 465     ASP B   108                                                      
REMARK 465     LEU B   109                                                      
REMARK 465     VAL B   110                                                      
REMARK 465     THR B   111                                                      
REMARK 465     ILE B   112                                                      
REMARK 465     HIS B   113                                                      
REMARK 465     PRO B   114                                                      
REMARK 465     CYS B   115                                                      
REMARK 465     PRO B   116                                                      
REMARK 465     ASP B   117                                                      
REMARK 465     ILE B   118                                                      
REMARK 465     LYS B   119                                                      
REMARK 465     TYR B   120                                                      
REMARK 465     ALA B   121                                                      
REMARK 465     THR B   122                                                      
REMARK 465     ARG B   123                                                      
REMARK 465     ILE B   124                                                      
REMARK 465     SER B   125                                                      
REMARK 465     VAL B   126                                                      
REMARK 465     LEU B   127                                                      
REMARK 465     PRO B   128                                                      
REMARK 465     ILE B   129                                                      
REMARK 465     ALA B   130                                                      
REMARK 465     ASP B   131                                                      
REMARK 465     THR B   132                                                      
REMARK 465     ILE B   133                                                      
REMARK 465     GLU B   134                                                      
REMARK 465     GLY B   135                                                      
REMARK 465     ILE B   136                                                      
REMARK 465     THR B   137                                                      
REMARK 465     GLY B   138                                                      
REMARK 465     ASN B   139                                                      
REMARK 465     LEU B   140                                                      
REMARK 465     PHE B   141                                                      
REMARK 465     ASP B   142                                                      
REMARK 465     VAL B   143                                                      
REMARK 465     PHE B   144                                                      
REMARK 465     LEU B   145                                                      
REMARK 465     LYS B   146                                                      
REMARK 465     PRO B   147                                                      
REMARK 465     TYR B   148                                                      
REMARK 465     PHE B   149                                                      
REMARK 465     VAL B   150                                                      
REMARK 465     GLU B   151                                                      
REMARK 465     ALA B   152                                                      
REMARK 465     TYR B   153                                                      
REMARK 465     ARG B   154                                                      
REMARK 465     PRO B   155                                                      
REMARK 465     VAL B   156                                                      
REMARK 465     ARG B   157                                                      
REMARK 465     LYS B   158                                                      
REMARK 465     GLY B   159                                                      
REMARK 465     ASP B   160                                                      
REMARK 465     HIS B   161                                                      
REMARK 465     PHE B   162                                                      
REMARK 465     VAL B   163                                                      
REMARK 465     VAL B   164                                                      
REMARK 465     ARG B   165                                                      
REMARK 465     GLY B   166                                                      
REMARK 465     GLY B   167                                                      
REMARK 465     MET B   168                                                      
REMARK 465     ARG B   169                                                      
REMARK 465     GLN B   170                                                      
REMARK 465     VAL B   171                                                      
REMARK 465     GLU B   172                                                      
REMARK 465     PHE B   173                                                      
REMARK 465     LYS B   174                                                      
REMARK 465     VAL B   175                                                      
REMARK 465     VAL B   176                                                      
REMARK 465     ASP B   177                                                      
REMARK 465     VAL B   178                                                      
REMARK 465     GLU B   179                                                      
REMARK 465     PRO B   180                                                      
REMARK 465     GLU B   181                                                      
REMARK 465     GLU B   182                                                      
REMARK 465     TYR B   183                                                      
REMARK 465     ALA B   184                                                      
REMARK 465     VAL B   185                                                      
REMARK 465     VAL B   186                                                      
REMARK 465     ALA B   187                                                      
REMARK 465     GLN B   188                                                      
REMARK 465     ASP B   189                                                      
REMARK 465     THR B   190                                                      
REMARK 465     ILE B   191                                                      
REMARK 465     ILE B   192                                                      
REMARK 465     HIS B   193                                                      
REMARK 465     TRP B   194                                                      
REMARK 465     GLU B   195                                                      
REMARK 465     GLY B   196                                                      
REMARK 465     GLU B   197                                                      
REMARK 465     PRO B   198                                                      
REMARK 465     ILE B   199                                                      
REMARK 465     ASN B   200                                                      
REMARK 465     ARG B   201                                                      
REMARK 465     GLU B   202                                                      
REMARK 465     ASP B   203                                                      
REMARK 465     GLU B   204                                                      
REMARK 465     GLU B   205                                                      
REMARK 465     ASN B   206                                                      
REMARK 465     ASN B   207                                                      
REMARK 465     MET B   208                                                      
REMARK 465     GLN B   718                                                      
REMARK 465     HIS B   719                                                      
REMARK 465     GLU B   720                                                      
REMARK 465     ALA B   721                                                      
REMARK 465     GLU B   722                                                      
REMARK 465     LYS B   723                                                      
REMARK 465     GLU B   724                                                      
REMARK 465     VAL B   725                                                      
REMARK 465     LYS B   726                                                      
REMARK 465     VAL B   727                                                      
REMARK 465     GLU B   728                                                      
REMARK 465     GLY B   729                                                      
REMARK 465     GLU B   730                                                      
REMARK 465     ASP B   731                                                      
REMARK 465     VAL B   732                                                      
REMARK 465     GLU B   733                                                      
REMARK 465     MET B   734                                                      
REMARK 465     THR B   735                                                      
REMARK 465     ASP B   736                                                      
REMARK 465     GLU B   737                                                      
REMARK 465     GLY B   738                                                      
REMARK 465     ALA B   739                                                      
REMARK 465     LYS B   740                                                      
REMARK 465     ALA B   741                                                      
REMARK 465     GLU B   742                                                      
REMARK 465     GLN B   743                                                      
REMARK 465     GLU B   744                                                      
REMARK 465     PRO B   745                                                      
REMARK 465     GLU B   746                                                      
REMARK 465     VAL B   747                                                      
REMARK 465     ASP B   748                                                      
REMARK 465     PRO B   749                                                      
REMARK 465     VAL B   750                                                      
REMARK 465     PRO B   751                                                      
REMARK 465     TYR B   752                                                      
REMARK 465     ILE B   753                                                      
REMARK 465     THR B   754                                                      
REMARK 465     LYS B   755                                                      
REMARK 465     GLU B   756                                                      
REMARK 465     HIS B   757                                                      
REMARK 465     PHE B   758                                                      
REMARK 465     ALA B   759                                                      
REMARK 465     GLU B   760                                                      
REMARK 465     ALA B   761                                                      
REMARK 465     MET B   762                                                      
REMARK 465     LYS B   763                                                      
REMARK 465     THR B   764                                                      
REMARK 465     ALA B   765                                                      
REMARK 465     LYS B   766                                                      
REMARK 465     ARG B   767                                                      
REMARK 465     SER B   768                                                      
REMARK 465     VAL B   769                                                      
REMARK 465     SER B   770                                                      
REMARK 465     ASP B   771                                                      
REMARK 465     ALA B   772                                                      
REMARK 465     GLU B   773                                                      
REMARK 465     LEU B   774                                                      
REMARK 465     ARG B   775                                                      
REMARK 465     ARG B   776                                                      
REMARK 465     TYR B   777                                                      
REMARK 465     GLU B   778                                                      
REMARK 465     ALA B   779                                                      
REMARK 465     TYR B   780                                                      
REMARK 465     SER B   781                                                      
REMARK 465     GLN B   782                                                      
REMARK 465     GLN B   783                                                      
REMARK 465     MET B   784                                                      
REMARK 465     LYS B   785                                                      
REMARK 465     ALA B   786                                                      
REMARK 465     SER B   787                                                      
REMARK 465     ARG B   788                                                      
REMARK 465     GLY B   789                                                      
REMARK 465     GLN B   790                                                      
REMARK 465     PHE B   791                                                      
REMARK 465     SER B   792                                                      
REMARK 465     ASN B   793                                                      
REMARK 465     PHE B   794                                                      
REMARK 465     ASN B   795                                                      
REMARK 465     PHE B   796                                                      
REMARK 465     ASN B   797                                                      
REMARK 465     ASP B   798                                                      
REMARK 465     ALA B   799                                                      
REMARK 465     PRO B   800                                                      
REMARK 465     LEU B   801                                                      
REMARK 465     GLY B   802                                                      
REMARK 465     THR B   803                                                      
REMARK 465     THR B   804                                                      
REMARK 465     ALA B   805                                                      
REMARK 465     THR B   806                                                      
REMARK 465     ASP B   807                                                      
REMARK 465     ASN B   808                                                      
REMARK 465     ALA B   809                                                      
REMARK 465     ASN B   810                                                      
REMARK 465     SER B   811                                                      
REMARK 465     ASN B   812                                                      
REMARK 465     ASN B   813                                                      
REMARK 465     SER B   814                                                      
REMARK 465     ALA B   815                                                      
REMARK 465     PRO B   816                                                      
REMARK 465     SER B   817                                                      
REMARK 465     GLY B   818                                                      
REMARK 465     ALA B   819                                                      
REMARK 465     GLY B   820                                                      
REMARK 465     ALA B   821                                                      
REMARK 465     ALA B   822                                                      
REMARK 465     PHE B   823                                                      
REMARK 465     GLY B   824                                                      
REMARK 465     SER B   825                                                      
REMARK 465     ASN B   826                                                      
REMARK 465     ALA B   827                                                      
REMARK 465     GLU B   828                                                      
REMARK 465     GLU B   829                                                      
REMARK 465     ASP B   830                                                      
REMARK 465     ASP B   831                                                      
REMARK 465     ASP B   832                                                      
REMARK 465     LEU B   833                                                      
REMARK 465     TYR B   834                                                      
REMARK 465     SER B   835                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLY C     2                                                      
REMARK 465     GLU C     3                                                      
REMARK 465     GLU C     4                                                      
REMARK 465     HIS C     5                                                      
REMARK 465     LYS C     6                                                      
REMARK 465     PRO C     7                                                      
REMARK 465     LEU C     8                                                      
REMARK 465     LEU C     9                                                      
REMARK 465     ASP C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     SER C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     VAL C    14                                                      
REMARK 465     ASP C    15                                                      
REMARK 465     PRO C    16                                                      
REMARK 465     ARG C    17                                                      
REMARK 465     GLU C    18                                                      
REMARK 465     GLU C    19                                                      
REMARK 465     ASP C    20                                                      
REMARK 465     LYS C    21                                                      
REMARK 465     THR C    22                                                      
REMARK 465     ALA C    23                                                      
REMARK 465     THR C    24                                                      
REMARK 465     ALA C    25                                                      
REMARK 465     ILE C    26                                                      
REMARK 465     LEU C    27                                                      
REMARK 465     ARG C    28                                                      
REMARK 465     ARG C    29                                                      
REMARK 465     LYS C    30                                                      
REMARK 465     LYS C    31                                                      
REMARK 465     LYS C    32                                                      
REMARK 465     ASP C    33                                                      
REMARK 465     ASN C    34                                                      
REMARK 465     MET C    35                                                      
REMARK 465     LEU C    36                                                      
REMARK 465     LEU C    37                                                      
REMARK 465     VAL C    38                                                      
REMARK 465     ASP C    39                                                      
REMARK 465     ASP C    40                                                      
REMARK 465     ALA C    41                                                      
REMARK 465     ILE C    42                                                      
REMARK 465     ASN C    43                                                      
REMARK 465     ASP C    44                                                      
REMARK 465     ASP C    45                                                      
REMARK 465     ASN C    46                                                      
REMARK 465     SER C    47                                                      
REMARK 465     VAL C    48                                                      
REMARK 465     ILE C    49                                                      
REMARK 465     ALA C    50                                                      
REMARK 465     ILE C    51                                                      
REMARK 465     ASN C    52                                                      
REMARK 465     SER C    53                                                      
REMARK 465     ASN C    54                                                      
REMARK 465     THR C    55                                                      
REMARK 465     MET C    56                                                      
REMARK 465     ASP C    57                                                      
REMARK 465     LYS C    58                                                      
REMARK 465     LEU C    59                                                      
REMARK 465     GLU C    60                                                      
REMARK 465     LEU C    61                                                      
REMARK 465     PHE C    62                                                      
REMARK 465     ARG C    63                                                      
REMARK 465     GLY C    64                                                      
REMARK 465     ASP C    65                                                      
REMARK 465     THR C    66                                                      
REMARK 465     VAL C    67                                                      
REMARK 465     LEU C    68                                                      
REMARK 465     VAL C    69                                                      
REMARK 465     LYS C    70                                                      
REMARK 465     GLY C    71                                                      
REMARK 465     LYS C    72                                                      
REMARK 465     LYS C    73                                                      
REMARK 465     ARG C    74                                                      
REMARK 465     LYS C    75                                                      
REMARK 465     ASP C    76                                                      
REMARK 465     THR C    77                                                      
REMARK 465     VAL C    78                                                      
REMARK 465     LEU C    79                                                      
REMARK 465     ILE C    80                                                      
REMARK 465     VAL C    81                                                      
REMARK 465     LEU C    82                                                      
REMARK 465     ILE C    83                                                      
REMARK 465     ASP C    84                                                      
REMARK 465     ASP C    85                                                      
REMARK 465     GLU C    86                                                      
REMARK 465     LEU C    87                                                      
REMARK 465     GLU C    88                                                      
REMARK 465     ASP C    89                                                      
REMARK 465     GLY C    90                                                      
REMARK 465     ALA C    91                                                      
REMARK 465     CYS C    92                                                      
REMARK 465     ARG C    93                                                      
REMARK 465     ILE C    94                                                      
REMARK 465     ASN C    95                                                      
REMARK 465     ARG C    96                                                      
REMARK 465     VAL C    97                                                      
REMARK 465     VAL C    98                                                      
REMARK 465     ARG C    99                                                      
REMARK 465     ASN C   100                                                      
REMARK 465     ASN C   101                                                      
REMARK 465     LEU C   102                                                      
REMARK 465     ARG C   103                                                      
REMARK 465     ILE C   104                                                      
REMARK 465     ARG C   105                                                      
REMARK 465     LEU C   106                                                      
REMARK 465     GLY C   107                                                      
REMARK 465     ASP C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     VAL C   110                                                      
REMARK 465     THR C   111                                                      
REMARK 465     ILE C   112                                                      
REMARK 465     HIS C   113                                                      
REMARK 465     PRO C   114                                                      
REMARK 465     CYS C   115                                                      
REMARK 465     PRO C   116                                                      
REMARK 465     ASP C   117                                                      
REMARK 465     ILE C   118                                                      
REMARK 465     LYS C   119                                                      
REMARK 465     TYR C   120                                                      
REMARK 465     ALA C   121                                                      
REMARK 465     THR C   122                                                      
REMARK 465     ARG C   123                                                      
REMARK 465     ILE C   124                                                      
REMARK 465     SER C   125                                                      
REMARK 465     VAL C   126                                                      
REMARK 465     LEU C   127                                                      
REMARK 465     PRO C   128                                                      
REMARK 465     ILE C   129                                                      
REMARK 465     ALA C   130                                                      
REMARK 465     ASP C   131                                                      
REMARK 465     THR C   132                                                      
REMARK 465     ILE C   133                                                      
REMARK 465     GLU C   134                                                      
REMARK 465     GLY C   135                                                      
REMARK 465     ILE C   136                                                      
REMARK 465     THR C   137                                                      
REMARK 465     GLY C   138                                                      
REMARK 465     ASN C   139                                                      
REMARK 465     LEU C   140                                                      
REMARK 465     PHE C   141                                                      
REMARK 465     ASP C   142                                                      
REMARK 465     VAL C   143                                                      
REMARK 465     PHE C   144                                                      
REMARK 465     LEU C   145                                                      
REMARK 465     LYS C   146                                                      
REMARK 465     PRO C   147                                                      
REMARK 465     TYR C   148                                                      
REMARK 465     PHE C   149                                                      
REMARK 465     VAL C   150                                                      
REMARK 465     GLU C   151                                                      
REMARK 465     ALA C   152                                                      
REMARK 465     TYR C   153                                                      
REMARK 465     ARG C   154                                                      
REMARK 465     PRO C   155                                                      
REMARK 465     VAL C   156                                                      
REMARK 465     ARG C   157                                                      
REMARK 465     LYS C   158                                                      
REMARK 465     GLY C   159                                                      
REMARK 465     ASP C   160                                                      
REMARK 465     HIS C   161                                                      
REMARK 465     PHE C   162                                                      
REMARK 465     VAL C   163                                                      
REMARK 465     VAL C   164                                                      
REMARK 465     ARG C   165                                                      
REMARK 465     GLY C   166                                                      
REMARK 465     GLY C   167                                                      
REMARK 465     MET C   168                                                      
REMARK 465     ARG C   169                                                      
REMARK 465     GLN C   170                                                      
REMARK 465     VAL C   171                                                      
REMARK 465     GLU C   172                                                      
REMARK 465     PHE C   173                                                      
REMARK 465     LYS C   174                                                      
REMARK 465     VAL C   175                                                      
REMARK 465     VAL C   176                                                      
REMARK 465     ASP C   177                                                      
REMARK 465     VAL C   178                                                      
REMARK 465     GLU C   179                                                      
REMARK 465     PRO C   180                                                      
REMARK 465     GLU C   181                                                      
REMARK 465     GLU C   182                                                      
REMARK 465     TYR C   183                                                      
REMARK 465     ALA C   184                                                      
REMARK 465     VAL C   185                                                      
REMARK 465     VAL C   186                                                      
REMARK 465     ALA C   187                                                      
REMARK 465     GLN C   188                                                      
REMARK 465     ASP C   189                                                      
REMARK 465     THR C   190                                                      
REMARK 465     ILE C   191                                                      
REMARK 465     ILE C   192                                                      
REMARK 465     HIS C   193                                                      
REMARK 465     TRP C   194                                                      
REMARK 465     GLU C   195                                                      
REMARK 465     GLY C   196                                                      
REMARK 465     GLU C   197                                                      
REMARK 465     PRO C   198                                                      
REMARK 465     ILE C   199                                                      
REMARK 465     ASN C   200                                                      
REMARK 465     ARG C   201                                                      
REMARK 465     GLU C   202                                                      
REMARK 465     ASP C   203                                                      
REMARK 465     GLU C   204                                                      
REMARK 465     GLU C   205                                                      
REMARK 465     ASN C   206                                                      
REMARK 465     ASN C   207                                                      
REMARK 465     MET C   208                                                      
REMARK 465     LEU C   439                                                      
REMARK 465     ILE C   440                                                      
REMARK 465     ASP C   441                                                      
REMARK 465     LEU C   442                                                      
REMARK 465     ASP C   443                                                      
REMARK 465     GLU C   444                                                      
REMARK 465     ASP C   445                                                      
REMARK 465     GLU C   446                                                      
REMARK 465     ILE C   447                                                      
REMARK 465     ASP C   448                                                      
REMARK 465     ALA C   449                                                      
REMARK 465     GLU C   450                                                      
REMARK 465     VAL C   451                                                      
REMARK 465     GLN C   718                                                      
REMARK 465     HIS C   719                                                      
REMARK 465     GLU C   720                                                      
REMARK 465     ALA C   721                                                      
REMARK 465     GLU C   722                                                      
REMARK 465     LYS C   723                                                      
REMARK 465     GLU C   724                                                      
REMARK 465     VAL C   725                                                      
REMARK 465     LYS C   726                                                      
REMARK 465     VAL C   727                                                      
REMARK 465     GLU C   728                                                      
REMARK 465     GLY C   729                                                      
REMARK 465     GLU C   730                                                      
REMARK 465     ASP C   731                                                      
REMARK 465     VAL C   732                                                      
REMARK 465     GLU C   733                                                      
REMARK 465     MET C   734                                                      
REMARK 465     THR C   735                                                      
REMARK 465     ASP C   736                                                      
REMARK 465     GLU C   737                                                      
REMARK 465     GLY C   738                                                      
REMARK 465     ALA C   739                                                      
REMARK 465     LYS C   740                                                      
REMARK 465     ALA C   741                                                      
REMARK 465     GLU C   742                                                      
REMARK 465     GLN C   743                                                      
REMARK 465     GLU C   744                                                      
REMARK 465     PRO C   745                                                      
REMARK 465     GLU C   746                                                      
REMARK 465     GLN C   783                                                      
REMARK 465     MET C   784                                                      
REMARK 465     LYS C   785                                                      
REMARK 465     ALA C   786                                                      
REMARK 465     SER C   787                                                      
REMARK 465     ARG C   788                                                      
REMARK 465     GLY C   789                                                      
REMARK 465     GLN C   790                                                      
REMARK 465     PHE C   791                                                      
REMARK 465     SER C   792                                                      
REMARK 465     ASN C   793                                                      
REMARK 465     PHE C   794                                                      
REMARK 465     ASN C   795                                                      
REMARK 465     PHE C   796                                                      
REMARK 465     ASN C   797                                                      
REMARK 465     ASP C   798                                                      
REMARK 465     ALA C   799                                                      
REMARK 465     PRO C   800                                                      
REMARK 465     LEU C   801                                                      
REMARK 465     GLY C   802                                                      
REMARK 465     THR C   803                                                      
REMARK 465     THR C   804                                                      
REMARK 465     ALA C   805                                                      
REMARK 465     THR C   806                                                      
REMARK 465     ASP C   807                                                      
REMARK 465     ASN C   808                                                      
REMARK 465     ALA C   809                                                      
REMARK 465     ASN C   810                                                      
REMARK 465     SER C   811                                                      
REMARK 465     ASN C   812                                                      
REMARK 465     ASN C   813                                                      
REMARK 465     SER C   814                                                      
REMARK 465     ALA C   815                                                      
REMARK 465     PRO C   816                                                      
REMARK 465     SER C   817                                                      
REMARK 465     GLY C   818                                                      
REMARK 465     ALA C   819                                                      
REMARK 465     GLY C   820                                                      
REMARK 465     ALA C   821                                                      
REMARK 465     ALA C   822                                                      
REMARK 465     PHE C   823                                                      
REMARK 465     GLY C   824                                                      
REMARK 465     SER C   825                                                      
REMARK 465     ASN C   826                                                      
REMARK 465     ALA C   827                                                      
REMARK 465     GLU C   828                                                      
REMARK 465     GLU C   829                                                      
REMARK 465     ASP C   830                                                      
REMARK 465     ASP C   831                                                      
REMARK 465     ASP C   832                                                      
REMARK 465     LEU C   833                                                      
REMARK 465     TYR C   834                                                      
REMARK 465     SER C   835                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLY D     2                                                      
REMARK 465     GLU D     3                                                      
REMARK 465     GLU D     4                                                      
REMARK 465     HIS D     5                                                      
REMARK 465     LYS D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     LEU D     8                                                      
REMARK 465     LEU D     9                                                      
REMARK 465     ASP D    10                                                      
REMARK 465     ALA D    11                                                      
REMARK 465     SER D    12                                                      
REMARK 465     GLY D    13                                                      
REMARK 465     VAL D    14                                                      
REMARK 465     ASP D    15                                                      
REMARK 465     PRO D    16                                                      
REMARK 465     ARG D    17                                                      
REMARK 465     GLU D    18                                                      
REMARK 465     GLU D    19                                                      
REMARK 465     ASP D    20                                                      
REMARK 465     LYS D    21                                                      
REMARK 465     THR D    22                                                      
REMARK 465     ALA D    23                                                      
REMARK 465     THR D    24                                                      
REMARK 465     ALA D    25                                                      
REMARK 465     ILE D    26                                                      
REMARK 465     LEU D    27                                                      
REMARK 465     ARG D    28                                                      
REMARK 465     ARG D    29                                                      
REMARK 465     LYS D    30                                                      
REMARK 465     LYS D    31                                                      
REMARK 465     LYS D    32                                                      
REMARK 465     ASP D    33                                                      
REMARK 465     ASN D    34                                                      
REMARK 465     MET D    35                                                      
REMARK 465     LEU D    36                                                      
REMARK 465     LEU D    37                                                      
REMARK 465     VAL D    38                                                      
REMARK 465     ASP D    39                                                      
REMARK 465     ASP D    40                                                      
REMARK 465     ALA D    41                                                      
REMARK 465     ILE D    42                                                      
REMARK 465     ASN D    43                                                      
REMARK 465     ASP D    44                                                      
REMARK 465     ASP D    45                                                      
REMARK 465     ASN D    46                                                      
REMARK 465     SER D    47                                                      
REMARK 465     VAL D    48                                                      
REMARK 465     ILE D    49                                                      
REMARK 465     ALA D    50                                                      
REMARK 465     ILE D    51                                                      
REMARK 465     ASN D    52                                                      
REMARK 465     SER D    53                                                      
REMARK 465     ASN D    54                                                      
REMARK 465     THR D    55                                                      
REMARK 465     MET D    56                                                      
REMARK 465     ASP D    57                                                      
REMARK 465     LYS D    58                                                      
REMARK 465     LEU D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     LEU D    61                                                      
REMARK 465     PHE D    62                                                      
REMARK 465     ARG D    63                                                      
REMARK 465     GLY D    64                                                      
REMARK 465     ASP D    65                                                      
REMARK 465     THR D    66                                                      
REMARK 465     VAL D    67                                                      
REMARK 465     LEU D    68                                                      
REMARK 465     VAL D    69                                                      
REMARK 465     LYS D    70                                                      
REMARK 465     GLY D    71                                                      
REMARK 465     LYS D    72                                                      
REMARK 465     LYS D    73                                                      
REMARK 465     ARG D    74                                                      
REMARK 465     LYS D    75                                                      
REMARK 465     ASP D    76                                                      
REMARK 465     THR D    77                                                      
REMARK 465     VAL D    78                                                      
REMARK 465     LEU D    79                                                      
REMARK 465     ILE D    80                                                      
REMARK 465     VAL D    81                                                      
REMARK 465     LEU D    82                                                      
REMARK 465     ILE D    83                                                      
REMARK 465     ASP D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     GLU D    86                                                      
REMARK 465     LEU D    87                                                      
REMARK 465     GLU D    88                                                      
REMARK 465     ASP D    89                                                      
REMARK 465     GLY D    90                                                      
REMARK 465     ALA D    91                                                      
REMARK 465     CYS D    92                                                      
REMARK 465     ARG D    93                                                      
REMARK 465     ILE D    94                                                      
REMARK 465     ASN D    95                                                      
REMARK 465     ARG D    96                                                      
REMARK 465     VAL D    97                                                      
REMARK 465     VAL D    98                                                      
REMARK 465     ARG D    99                                                      
REMARK 465     ASN D   100                                                      
REMARK 465     ASN D   101                                                      
REMARK 465     LEU D   102                                                      
REMARK 465     ARG D   103                                                      
REMARK 465     ILE D   104                                                      
REMARK 465     ARG D   105                                                      
REMARK 465     LEU D   106                                                      
REMARK 465     GLY D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     LEU D   109                                                      
REMARK 465     VAL D   110                                                      
REMARK 465     THR D   111                                                      
REMARK 465     ILE D   112                                                      
REMARK 465     HIS D   113                                                      
REMARK 465     PRO D   114                                                      
REMARK 465     CYS D   115                                                      
REMARK 465     PRO D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     ILE D   118                                                      
REMARK 465     LYS D   119                                                      
REMARK 465     TYR D   120                                                      
REMARK 465     ALA D   121                                                      
REMARK 465     THR D   122                                                      
REMARK 465     ARG D   123                                                      
REMARK 465     ILE D   124                                                      
REMARK 465     SER D   125                                                      
REMARK 465     VAL D   126                                                      
REMARK 465     LEU D   127                                                      
REMARK 465     PRO D   128                                                      
REMARK 465     ILE D   129                                                      
REMARK 465     ALA D   130                                                      
REMARK 465     ASP D   131                                                      
REMARK 465     THR D   132                                                      
REMARK 465     ILE D   133                                                      
REMARK 465     GLU D   134                                                      
REMARK 465     GLY D   135                                                      
REMARK 465     ILE D   136                                                      
REMARK 465     THR D   137                                                      
REMARK 465     GLY D   138                                                      
REMARK 465     ASN D   139                                                      
REMARK 465     LEU D   140                                                      
REMARK 465     PHE D   141                                                      
REMARK 465     ASP D   142                                                      
REMARK 465     VAL D   143                                                      
REMARK 465     PHE D   144                                                      
REMARK 465     LEU D   145                                                      
REMARK 465     LYS D   146                                                      
REMARK 465     PRO D   147                                                      
REMARK 465     TYR D   148                                                      
REMARK 465     PHE D   149                                                      
REMARK 465     VAL D   150                                                      
REMARK 465     GLU D   151                                                      
REMARK 465     ALA D   152                                                      
REMARK 465     TYR D   153                                                      
REMARK 465     ARG D   154                                                      
REMARK 465     PRO D   155                                                      
REMARK 465     VAL D   156                                                      
REMARK 465     ARG D   157                                                      
REMARK 465     LYS D   158                                                      
REMARK 465     GLY D   159                                                      
REMARK 465     ASP D   160                                                      
REMARK 465     HIS D   161                                                      
REMARK 465     PHE D   162                                                      
REMARK 465     VAL D   163                                                      
REMARK 465     VAL D   164                                                      
REMARK 465     ARG D   165                                                      
REMARK 465     GLY D   166                                                      
REMARK 465     GLY D   167                                                      
REMARK 465     MET D   168                                                      
REMARK 465     ARG D   169                                                      
REMARK 465     GLN D   170                                                      
REMARK 465     VAL D   171                                                      
REMARK 465     GLU D   172                                                      
REMARK 465     PHE D   173                                                      
REMARK 465     LYS D   174                                                      
REMARK 465     VAL D   175                                                      
REMARK 465     VAL D   176                                                      
REMARK 465     ASP D   177                                                      
REMARK 465     VAL D   178                                                      
REMARK 465     GLU D   179                                                      
REMARK 465     PRO D   180                                                      
REMARK 465     GLU D   181                                                      
REMARK 465     GLU D   182                                                      
REMARK 465     TYR D   183                                                      
REMARK 465     ALA D   184                                                      
REMARK 465     VAL D   185                                                      
REMARK 465     VAL D   186                                                      
REMARK 465     ALA D   187                                                      
REMARK 465     GLN D   188                                                      
REMARK 465     ASP D   189                                                      
REMARK 465     THR D   190                                                      
REMARK 465     ILE D   191                                                      
REMARK 465     ILE D   192                                                      
REMARK 465     HIS D   193                                                      
REMARK 465     TRP D   194                                                      
REMARK 465     GLU D   195                                                      
REMARK 465     GLY D   196                                                      
REMARK 465     GLU D   197                                                      
REMARK 465     PRO D   198                                                      
REMARK 465     ILE D   199                                                      
REMARK 465     ASN D   200                                                      
REMARK 465     ARG D   201                                                      
REMARK 465     GLU D   202                                                      
REMARK 465     ASP D   203                                                      
REMARK 465     GLU D   204                                                      
REMARK 465     GLU D   205                                                      
REMARK 465     ASN D   206                                                      
REMARK 465     ASN D   207                                                      
REMARK 465     MET D   208                                                      
REMARK 465     ASP D   438                                                      
REMARK 465     LEU D   439                                                      
REMARK 465     ILE D   440                                                      
REMARK 465     ASP D   441                                                      
REMARK 465     LEU D   442                                                      
REMARK 465     ASP D   443                                                      
REMARK 465     GLU D   444                                                      
REMARK 465     ASP D   445                                                      
REMARK 465     GLU D   446                                                      
REMARK 465     ILE D   447                                                      
REMARK 465     ASP D   448                                                      
REMARK 465     ALA D   449                                                      
REMARK 465     GLU D   450                                                      
REMARK 465     VAL D   451                                                      
REMARK 465     LEU D   452                                                      
REMARK 465     ASP D   453                                                      
REMARK 465     SER D   454                                                      
REMARK 465     GLN D   718                                                      
REMARK 465     HIS D   719                                                      
REMARK 465     GLU D   720                                                      
REMARK 465     ALA D   721                                                      
REMARK 465     GLU D   722                                                      
REMARK 465     LYS D   723                                                      
REMARK 465     GLU D   724                                                      
REMARK 465     VAL D   725                                                      
REMARK 465     LYS D   726                                                      
REMARK 465     VAL D   727                                                      
REMARK 465     GLU D   728                                                      
REMARK 465     GLY D   729                                                      
REMARK 465     GLU D   730                                                      
REMARK 465     ASP D   731                                                      
REMARK 465     VAL D   732                                                      
REMARK 465     GLU D   733                                                      
REMARK 465     MET D   734                                                      
REMARK 465     THR D   735                                                      
REMARK 465     ASP D   736                                                      
REMARK 465     GLU D   737                                                      
REMARK 465     GLY D   738                                                      
REMARK 465     ALA D   739                                                      
REMARK 465     LYS D   740                                                      
REMARK 465     ALA D   741                                                      
REMARK 465     GLU D   742                                                      
REMARK 465     GLN D   743                                                      
REMARK 465     GLU D   744                                                      
REMARK 465     PRO D   745                                                      
REMARK 465     GLU D   746                                                      
REMARK 465     SER D   792                                                      
REMARK 465     ASN D   793                                                      
REMARK 465     PHE D   794                                                      
REMARK 465     ASN D   795                                                      
REMARK 465     PHE D   796                                                      
REMARK 465     ASN D   797                                                      
REMARK 465     ASP D   798                                                      
REMARK 465     ALA D   799                                                      
REMARK 465     PRO D   800                                                      
REMARK 465     LEU D   801                                                      
REMARK 465     GLY D   802                                                      
REMARK 465     THR D   803                                                      
REMARK 465     THR D   804                                                      
REMARK 465     ALA D   805                                                      
REMARK 465     THR D   806                                                      
REMARK 465     ASP D   807                                                      
REMARK 465     ASN D   808                                                      
REMARK 465     ALA D   809                                                      
REMARK 465     ASN D   810                                                      
REMARK 465     SER D   811                                                      
REMARK 465     ASN D   812                                                      
REMARK 465     ASN D   813                                                      
REMARK 465     SER D   814                                                      
REMARK 465     ALA D   815                                                      
REMARK 465     PRO D   816                                                      
REMARK 465     SER D   817                                                      
REMARK 465     GLY D   818                                                      
REMARK 465     ALA D   819                                                      
REMARK 465     GLY D   820                                                      
REMARK 465     ALA D   821                                                      
REMARK 465     ALA D   822                                                      
REMARK 465     PHE D   823                                                      
REMARK 465     GLY D   824                                                      
REMARK 465     SER D   825                                                      
REMARK 465     ASN D   826                                                      
REMARK 465     ALA D   827                                                      
REMARK 465     GLU D   828                                                      
REMARK 465     GLU D   829                                                      
REMARK 465     ASP D   830                                                      
REMARK 465     ASP D   831                                                      
REMARK 465     ASP D   832                                                      
REMARK 465     LEU D   833                                                      
REMARK 465     TYR D   834                                                      
REMARK 465     SER D   835                                                      
REMARK 465     MET E     1                                                      
REMARK 465     GLY E     2                                                      
REMARK 465     GLU E     3                                                      
REMARK 465     GLU E     4                                                      
REMARK 465     HIS E     5                                                      
REMARK 465     LYS E     6                                                      
REMARK 465     PRO E     7                                                      
REMARK 465     LEU E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     ASP E    10                                                      
REMARK 465     ALA E    11                                                      
REMARK 465     SER E    12                                                      
REMARK 465     GLY E    13                                                      
REMARK 465     VAL E    14                                                      
REMARK 465     ASP E    15                                                      
REMARK 465     PRO E    16                                                      
REMARK 465     ARG E    17                                                      
REMARK 465     GLU E    18                                                      
REMARK 465     GLU E    19                                                      
REMARK 465     ASP E    20                                                      
REMARK 465     LYS E    21                                                      
REMARK 465     THR E    22                                                      
REMARK 465     ALA E    23                                                      
REMARK 465     THR E    24                                                      
REMARK 465     ALA E    25                                                      
REMARK 465     ILE E    26                                                      
REMARK 465     LEU E    27                                                      
REMARK 465     ARG E    28                                                      
REMARK 465     ARG E    29                                                      
REMARK 465     LYS E    30                                                      
REMARK 465     LYS E    31                                                      
REMARK 465     LYS E    32                                                      
REMARK 465     ASP E    33                                                      
REMARK 465     ASN E    34                                                      
REMARK 465     MET E    35                                                      
REMARK 465     LEU E    36                                                      
REMARK 465     LEU E    37                                                      
REMARK 465     VAL E    38                                                      
REMARK 465     ASP E    39                                                      
REMARK 465     ASP E    40                                                      
REMARK 465     ALA E    41                                                      
REMARK 465     ILE E    42                                                      
REMARK 465     ASN E    43                                                      
REMARK 465     ASP E    44                                                      
REMARK 465     ASP E    45                                                      
REMARK 465     ASN E    46                                                      
REMARK 465     SER E    47                                                      
REMARK 465     VAL E    48                                                      
REMARK 465     ILE E    49                                                      
REMARK 465     ALA E    50                                                      
REMARK 465     ILE E    51                                                      
REMARK 465     ASN E    52                                                      
REMARK 465     SER E    53                                                      
REMARK 465     ASN E    54                                                      
REMARK 465     THR E    55                                                      
REMARK 465     MET E    56                                                      
REMARK 465     ASP E    57                                                      
REMARK 465     LYS E    58                                                      
REMARK 465     LEU E    59                                                      
REMARK 465     GLU E    60                                                      
REMARK 465     LEU E    61                                                      
REMARK 465     PHE E    62                                                      
REMARK 465     ARG E    63                                                      
REMARK 465     GLY E    64                                                      
REMARK 465     ASP E    65                                                      
REMARK 465     THR E    66                                                      
REMARK 465     VAL E    67                                                      
REMARK 465     LEU E    68                                                      
REMARK 465     VAL E    69                                                      
REMARK 465     LYS E    70                                                      
REMARK 465     GLY E    71                                                      
REMARK 465     LYS E    72                                                      
REMARK 465     LYS E    73                                                      
REMARK 465     ARG E    74                                                      
REMARK 465     LYS E    75                                                      
REMARK 465     ASP E    76                                                      
REMARK 465     THR E    77                                                      
REMARK 465     VAL E    78                                                      
REMARK 465     LEU E    79                                                      
REMARK 465     ILE E    80                                                      
REMARK 465     VAL E    81                                                      
REMARK 465     LEU E    82                                                      
REMARK 465     ILE E    83                                                      
REMARK 465     ASP E    84                                                      
REMARK 465     ASP E    85                                                      
REMARK 465     GLU E    86                                                      
REMARK 465     LEU E    87                                                      
REMARK 465     GLU E    88                                                      
REMARK 465     ASP E    89                                                      
REMARK 465     GLY E    90                                                      
REMARK 465     ALA E    91                                                      
REMARK 465     CYS E    92                                                      
REMARK 465     ARG E    93                                                      
REMARK 465     ILE E    94                                                      
REMARK 465     ASN E    95                                                      
REMARK 465     ARG E    96                                                      
REMARK 465     VAL E    97                                                      
REMARK 465     VAL E    98                                                      
REMARK 465     ARG E    99                                                      
REMARK 465     ASN E   100                                                      
REMARK 465     ASN E   101                                                      
REMARK 465     LEU E   102                                                      
REMARK 465     ARG E   103                                                      
REMARK 465     ILE E   104                                                      
REMARK 465     ARG E   105                                                      
REMARK 465     LEU E   106                                                      
REMARK 465     GLY E   107                                                      
REMARK 465     ASP E   108                                                      
REMARK 465     LEU E   109                                                      
REMARK 465     VAL E   110                                                      
REMARK 465     THR E   111                                                      
REMARK 465     ILE E   112                                                      
REMARK 465     HIS E   113                                                      
REMARK 465     PRO E   114                                                      
REMARK 465     CYS E   115                                                      
REMARK 465     PRO E   116                                                      
REMARK 465     ASP E   117                                                      
REMARK 465     ILE E   118                                                      
REMARK 465     LYS E   119                                                      
REMARK 465     TYR E   120                                                      
REMARK 465     ALA E   121                                                      
REMARK 465     THR E   122                                                      
REMARK 465     ARG E   123                                                      
REMARK 465     ILE E   124                                                      
REMARK 465     SER E   125                                                      
REMARK 465     VAL E   126                                                      
REMARK 465     LEU E   127                                                      
REMARK 465     PRO E   128                                                      
REMARK 465     ILE E   129                                                      
REMARK 465     ALA E   130                                                      
REMARK 465     ASP E   131                                                      
REMARK 465     THR E   132                                                      
REMARK 465     ILE E   133                                                      
REMARK 465     GLU E   134                                                      
REMARK 465     GLY E   135                                                      
REMARK 465     ILE E   136                                                      
REMARK 465     THR E   137                                                      
REMARK 465     GLY E   138                                                      
REMARK 465     ASN E   139                                                      
REMARK 465     LEU E   140                                                      
REMARK 465     PHE E   141                                                      
REMARK 465     ASP E   142                                                      
REMARK 465     VAL E   143                                                      
REMARK 465     PHE E   144                                                      
REMARK 465     LEU E   145                                                      
REMARK 465     LYS E   146                                                      
REMARK 465     PRO E   147                                                      
REMARK 465     TYR E   148                                                      
REMARK 465     PHE E   149                                                      
REMARK 465     VAL E   150                                                      
REMARK 465     GLU E   151                                                      
REMARK 465     ALA E   152                                                      
REMARK 465     TYR E   153                                                      
REMARK 465     ARG E   154                                                      
REMARK 465     PRO E   155                                                      
REMARK 465     VAL E   156                                                      
REMARK 465     ARG E   157                                                      
REMARK 465     LYS E   158                                                      
REMARK 465     GLY E   159                                                      
REMARK 465     ASP E   160                                                      
REMARK 465     HIS E   161                                                      
REMARK 465     PHE E   162                                                      
REMARK 465     VAL E   163                                                      
REMARK 465     VAL E   164                                                      
REMARK 465     ARG E   165                                                      
REMARK 465     GLY E   166                                                      
REMARK 465     GLY E   167                                                      
REMARK 465     MET E   168                                                      
REMARK 465     ARG E   169                                                      
REMARK 465     GLN E   170                                                      
REMARK 465     VAL E   171                                                      
REMARK 465     GLU E   172                                                      
REMARK 465     PHE E   173                                                      
REMARK 465     LYS E   174                                                      
REMARK 465     VAL E   175                                                      
REMARK 465     VAL E   176                                                      
REMARK 465     ASP E   177                                                      
REMARK 465     VAL E   178                                                      
REMARK 465     GLU E   179                                                      
REMARK 465     PRO E   180                                                      
REMARK 465     GLU E   181                                                      
REMARK 465     GLU E   182                                                      
REMARK 465     TYR E   183                                                      
REMARK 465     ALA E   184                                                      
REMARK 465     VAL E   185                                                      
REMARK 465     VAL E   186                                                      
REMARK 465     ALA E   187                                                      
REMARK 465     GLN E   188                                                      
REMARK 465     ASP E   189                                                      
REMARK 465     THR E   190                                                      
REMARK 465     ILE E   191                                                      
REMARK 465     ILE E   192                                                      
REMARK 465     HIS E   193                                                      
REMARK 465     TRP E   194                                                      
REMARK 465     GLU E   195                                                      
REMARK 465     GLY E   196                                                      
REMARK 465     GLU E   197                                                      
REMARK 465     PRO E   198                                                      
REMARK 465     ILE E   199                                                      
REMARK 465     ASN E   200                                                      
REMARK 465     ARG E   201                                                      
REMARK 465     GLU E   202                                                      
REMARK 465     ASP E   203                                                      
REMARK 465     GLU E   204                                                      
REMARK 465     GLU E   205                                                      
REMARK 465     ASN E   206                                                      
REMARK 465     ASN E   207                                                      
REMARK 465     MET E   208                                                      
REMARK 465     MET E   437                                                      
REMARK 465     ASP E   438                                                      
REMARK 465     LEU E   439                                                      
REMARK 465     ILE E   440                                                      
REMARK 465     ASP E   441                                                      
REMARK 465     LEU E   442                                                      
REMARK 465     ASP E   443                                                      
REMARK 465     GLU E   444                                                      
REMARK 465     ASP E   445                                                      
REMARK 465     GLU E   446                                                      
REMARK 465     ILE E   447                                                      
REMARK 465     ASP E   448                                                      
REMARK 465     ALA E   449                                                      
REMARK 465     GLU E   450                                                      
REMARK 465     VAL E   451                                                      
REMARK 465     LEU E   452                                                      
REMARK 465     ASP E   453                                                      
REMARK 465     SER E   454                                                      
REMARK 465     LEU E   455                                                      
REMARK 465     GLY E   456                                                      
REMARK 465     LEU E   671                                                      
REMARK 465     ARG E   672                                                      
REMARK 465     LYS E   673                                                      
REMARK 465     THR E   674                                                      
REMARK 465     PRO E   675                                                      
REMARK 465     LEU E   676                                                      
REMARK 465     GLU E   677                                                      
REMARK 465     PRO E   678                                                      
REMARK 465     GLY E   679                                                      
REMARK 465     LEU E   680                                                      
REMARK 465     GLU E   681                                                      
REMARK 465     LEU E   682                                                      
REMARK 465     THR E   683                                                      
REMARK 465     ALA E   684                                                      
REMARK 465     ILE E   685                                                      
REMARK 465     ALA E   686                                                      
REMARK 465     LYS E   687                                                      
REMARK 465     ALA E   688                                                      
REMARK 465     THR E   689                                                      
REMARK 465     GLN E   690                                                      
REMARK 465     GLY E   691                                                      
REMARK 465     PHE E   692                                                      
REMARK 465     SER E   693                                                      
REMARK 465     GLY E   694                                                      
REMARK 465     ALA E   695                                                      
REMARK 465     ASP E   696                                                      
REMARK 465     LEU E   697                                                      
REMARK 465     LEU E   698                                                      
REMARK 465     TYR E   699                                                      
REMARK 465     ILE E   700                                                      
REMARK 465     VAL E   701                                                      
REMARK 465     GLN E   702                                                      
REMARK 465     ARG E   703                                                      
REMARK 465     ALA E   704                                                      
REMARK 465     ALA E   705                                                      
REMARK 465     LYS E   706                                                      
REMARK 465     TYR E   707                                                      
REMARK 465     ALA E   708                                                      
REMARK 465     ILE E   709                                                      
REMARK 465     LYS E   710                                                      
REMARK 465     ASP E   711                                                      
REMARK 465     SER E   712                                                      
REMARK 465     ILE E   713                                                      
REMARK 465     GLU E   714                                                      
REMARK 465     ALA E   715                                                      
REMARK 465     HIS E   716                                                      
REMARK 465     ARG E   717                                                      
REMARK 465     GLN E   718                                                      
REMARK 465     HIS E   719                                                      
REMARK 465     GLU E   720                                                      
REMARK 465     ALA E   721                                                      
REMARK 465     GLU E   722                                                      
REMARK 465     LYS E   723                                                      
REMARK 465     GLU E   724                                                      
REMARK 465     VAL E   725                                                      
REMARK 465     LYS E   726                                                      
REMARK 465     VAL E   727                                                      
REMARK 465     GLU E   728                                                      
REMARK 465     GLY E   729                                                      
REMARK 465     GLU E   730                                                      
REMARK 465     ASP E   731                                                      
REMARK 465     VAL E   732                                                      
REMARK 465     GLU E   733                                                      
REMARK 465     MET E   734                                                      
REMARK 465     THR E   735                                                      
REMARK 465     ASP E   736                                                      
REMARK 465     GLU E   737                                                      
REMARK 465     GLY E   738                                                      
REMARK 465     ALA E   739                                                      
REMARK 465     LYS E   740                                                      
REMARK 465     ALA E   741                                                      
REMARK 465     GLU E   742                                                      
REMARK 465     GLN E   743                                                      
REMARK 465     GLU E   744                                                      
REMARK 465     PRO E   745                                                      
REMARK 465     GLU E   746                                                      
REMARK 465     VAL E   747                                                      
REMARK 465     ASP E   748                                                      
REMARK 465     PRO E   749                                                      
REMARK 465     VAL E   750                                                      
REMARK 465     PRO E   751                                                      
REMARK 465     TYR E   752                                                      
REMARK 465     ILE E   753                                                      
REMARK 465     THR E   754                                                      
REMARK 465     LYS E   755                                                      
REMARK 465     GLU E   756                                                      
REMARK 465     HIS E   757                                                      
REMARK 465     PHE E   758                                                      
REMARK 465     ALA E   759                                                      
REMARK 465     GLU E   760                                                      
REMARK 465     ALA E   761                                                      
REMARK 465     MET E   762                                                      
REMARK 465     LYS E   763                                                      
REMARK 465     THR E   764                                                      
REMARK 465     ALA E   765                                                      
REMARK 465     LYS E   766                                                      
REMARK 465     ARG E   767                                                      
REMARK 465     SER E   768                                                      
REMARK 465     VAL E   769                                                      
REMARK 465     SER E   770                                                      
REMARK 465     ASP E   771                                                      
REMARK 465     ALA E   772                                                      
REMARK 465     GLU E   773                                                      
REMARK 465     LEU E   774                                                      
REMARK 465     ARG E   775                                                      
REMARK 465     ARG E   776                                                      
REMARK 465     TYR E   777                                                      
REMARK 465     GLU E   778                                                      
REMARK 465     ALA E   779                                                      
REMARK 465     TYR E   780                                                      
REMARK 465     SER E   781                                                      
REMARK 465     GLN E   782                                                      
REMARK 465     GLN E   783                                                      
REMARK 465     MET E   784                                                      
REMARK 465     LYS E   785                                                      
REMARK 465     ALA E   786                                                      
REMARK 465     SER E   787                                                      
REMARK 465     ARG E   788                                                      
REMARK 465     GLY E   789                                                      
REMARK 465     GLN E   790                                                      
REMARK 465     PHE E   791                                                      
REMARK 465     SER E   792                                                      
REMARK 465     ASN E   793                                                      
REMARK 465     PHE E   794                                                      
REMARK 465     ASN E   795                                                      
REMARK 465     PHE E   796                                                      
REMARK 465     ASN E   797                                                      
REMARK 465     ASP E   798                                                      
REMARK 465     ALA E   799                                                      
REMARK 465     PRO E   800                                                      
REMARK 465     LEU E   801                                                      
REMARK 465     GLY E   802                                                      
REMARK 465     THR E   803                                                      
REMARK 465     THR E   804                                                      
REMARK 465     ALA E   805                                                      
REMARK 465     THR E   806                                                      
REMARK 465     ASP E   807                                                      
REMARK 465     ASN E   808                                                      
REMARK 465     ALA E   809                                                      
REMARK 465     ASN E   810                                                      
REMARK 465     SER E   811                                                      
REMARK 465     ASN E   812                                                      
REMARK 465     ASN E   813                                                      
REMARK 465     SER E   814                                                      
REMARK 465     ALA E   815                                                      
REMARK 465     PRO E   816                                                      
REMARK 465     SER E   817                                                      
REMARK 465     GLY E   818                                                      
REMARK 465     ALA E   819                                                      
REMARK 465     GLY E   820                                                      
REMARK 465     ALA E   821                                                      
REMARK 465     ALA E   822                                                      
REMARK 465     PHE E   823                                                      
REMARK 465     GLY E   824                                                      
REMARK 465     SER E   825                                                      
REMARK 465     ASN E   826                                                      
REMARK 465     ALA E   827                                                      
REMARK 465     GLU E   828                                                      
REMARK 465     GLU E   829                                                      
REMARK 465     ASP E   830                                                      
REMARK 465     ASP E   831                                                      
REMARK 465     ASP E   832                                                      
REMARK 465     LEU E   833                                                      
REMARK 465     TYR E   834                                                      
REMARK 465     SER E   835                                                      
REMARK 465     MET G     1                                                      
REMARK 465     LEU G     2                                                      
REMARK 465     ILE G     3                                                      
REMARK 465     ARG G     4                                                      
REMARK 465     PHE G     5                                                      
REMARK 465     ARG G     6                                                      
REMARK 465     SER G     7                                                      
REMARK 465     LYS G     8                                                      
REMARK 465     ASN G     9                                                      
REMARK 465     GLY G    10                                                      
REMARK 465     THR G    11                                                      
REMARK 465     HIS G    12                                                      
REMARK 465     ARG G    13                                                      
REMARK 465     VAL G    14                                                      
REMARK 465     SER G    15                                                      
REMARK 465     CYS G    16                                                      
REMARK 465     GLN G    17                                                      
REMARK 465     GLU G    18                                                      
REMARK 465     ASN G    19                                                      
REMARK 465     ASP G    20                                                      
REMARK 465     LEU G    21                                                      
REMARK 465     PHE G    22                                                      
REMARK 465     GLY G    23                                                      
REMARK 465     THR G    24                                                      
REMARK 465     VAL G    25                                                      
REMARK 465     ILE G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     LYS G    28                                                      
REMARK 465     LEU G    29                                                      
REMARK 465     VAL G    30                                                      
REMARK 465     GLY G    31                                                      
REMARK 465     ASN G    32                                                      
REMARK 465     LEU G    33                                                      
REMARK 465     ASP G    34                                                      
REMARK 465     PRO G    35                                                      
REMARK 465     ASN G    36                                                      
REMARK 465     ALA G    37                                                      
REMARK 465     ASP G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     ASP G    40                                                      
REMARK 465     THR G    41                                                      
REMARK 465     PHE G    42                                                      
REMARK 465     THR G    43                                                      
REMARK 465     VAL G    44                                                      
REMARK 465     CYS G    45                                                      
REMARK 465     GLU G    46                                                      
REMARK 465     LYS G    47                                                      
REMARK 465     PRO G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     GLN G    50                                                      
REMARK 465     GLY G    51                                                      
REMARK 465     ILE G    52                                                      
REMARK 465     HIS G    53                                                      
REMARK 465     ALA G    54                                                      
REMARK 465     VAL G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     GLU G    57                                                      
REMARK 465     LEU G    58                                                      
REMARK 465     ALA G    59                                                      
REMARK 465     ASP G    60                                                      
REMARK 465     ARG G    61                                                      
REMARK 465     THR G    62                                                      
REMARK 465     VAL G    63                                                      
REMARK 465     MET G    64                                                      
REMARK 465     ASP G    65                                                      
REMARK 465     LEU G    66                                                      
REMARK 465     GLY G    67                                                      
REMARK 465     LEU G    68                                                      
REMARK 465     LYS G    69                                                      
REMARK 465     HIS G    70                                                      
REMARK 465     GLY G    71                                                      
REMARK 465     ASP G    72                                                      
REMARK 465     MET G    73                                                      
REMARK 465     LEU G    74                                                      
REMARK 465     ILE G    75                                                      
REMARK 465     LEU G    76                                                      
REMARK 465     ASN G    77                                                      
REMARK 465     TYR G    78                                                      
REMARK 465     SER G    79                                                      
REMARK 465     ASP G    80                                                      
REMARK 465     LYS G    81                                                      
REMARK 465     PRO G    82                                                      
REMARK 465     ALA G    83                                                      
REMARK 465     ASN G    84                                                      
REMARK 465     GLU G    85                                                      
REMARK 465     LYS G    86                                                      
REMARK 465     ASP G    87                                                      
REMARK 465     GLY G    88                                                      
REMARK 465     VAL G    89                                                      
REMARK 465     ASN G    90                                                      
REMARK 465     VAL G    91                                                      
REMARK 465     GLU G    92                                                      
REMARK 465     ILE G    93                                                      
REMARK 465     GLY G    94                                                      
REMARK 465     SER G    95                                                      
REMARK 465     VAL G    96                                                      
REMARK 465     GLY G    97                                                      
REMARK 465     ILE G    98                                                      
REMARK 465     ASP G    99                                                      
REMARK 465     SER G   100                                                      
REMARK 465     LYS G   101                                                      
REMARK 465     GLY G   102                                                      
REMARK 465     ILE G   103                                                      
REMARK 465     ARG G   104                                                      
REMARK 465     GLN G   105                                                      
REMARK 465     HIS G   106                                                      
REMARK 465     ARG G   107                                                      
REMARK 465     TYR G   108                                                      
REMARK 465     GLY G   109                                                      
REMARK 465     PRO G   110                                                      
REMARK 465     LEU G   111                                                      
REMARK 465     ARG G   112                                                      
REMARK 465     ILE G   113                                                      
REMARK 465     LYS G   114                                                      
REMARK 465     GLU G   115                                                      
REMARK 465     LEU G   128                                                      
REMARK 465     ILE G   129                                                      
REMARK 465     PRO G   130                                                      
REMARK 465     ARG G   131                                                      
REMARK 465     GLN G   132                                                      
REMARK 465     LYS G   133                                                      
REMARK 465     SER G   134                                                      
REMARK 465     LYS G   135                                                      
REMARK 465     LEU G   136                                                      
REMARK 465     CYS G   137                                                      
REMARK 465     LYS G   138                                                      
REMARK 465     HIS G   139                                                      
REMARK 465     GLY G   140                                                      
REMARK 465     ASP G   141                                                      
REMARK 465     ARG G   142                                                      
REMARK 465     GLY G   143                                                      
REMARK 465     MET G   144                                                      
REMARK 465     CYS G   145                                                      
REMARK 465     GLU G   146                                                      
REMARK 465     TYR G   147                                                      
REMARK 465     CYS G   148                                                      
REMARK 465     SER G   149                                                      
REMARK 465     PRO G   150                                                      
REMARK 465     LEU G   151                                                      
REMARK 465     ASN G   177                                                      
REMARK 465     GLU G   178                                                      
REMARK 465     ASN G   179                                                      
REMARK 465     ALA G   180                                                      
REMARK 465     ASN G   181                                                      
REMARK 465     LYS G   182                                                      
REMARK 465     LYS G   183                                                      
REMARK 465     GLU G   184                                                      
REMARK 465     ASN G   185                                                      
REMARK 465     GLY G   186                                                      
REMARK 465     SER G   187                                                      
REMARK 465     SER G   188                                                      
REMARK 465     TYR G   189                                                      
REMARK 465     ILE G   190                                                      
REMARK 465     SER G   191                                                      
REMARK 465     MET H     1                                                      
REMARK 465     LEU H    50                                                      
REMARK 465     GLU H    51                                                      
REMARK 465     ASP H    52                                                      
REMARK 465     GLY H    53                                                      
REMARK 465     ARG H    54                                                      
REMARK 465     THR H    55                                                      
REMARK 465     LEU H    56                                                      
REMARK 465     SER H    57                                                      
REMARK 465     ASP H    58                                                      
REMARK 465     TYR H    59                                                      
REMARK 465     ASN H    60                                                      
REMARK 465     ILE H    61                                                      
REMARK 465     GLN H    62                                                      
REMARK 465     LYS H    63                                                      
REMARK 465     GLU H    64                                                      
REMARK 465     SER H    65                                                      
REMARK 465     THR H    66                                                      
REMARK 465     LEU H    67                                                      
REMARK 465     HIS H    68                                                      
REMARK 465     LEU H    69                                                      
REMARK 465     VAL H    70                                                      
REMARK 465     LEU H    71                                                      
REMARK 465     ARG H    72                                                      
REMARK 465     LEU H    73                                                      
REMARK 465     ARG H    74                                                      
REMARK 465     GLY H    75                                                      
REMARK 465     GLY H    76                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CG2  THR C   262     O3B  ADP C   903              1.28            
REMARK 500   CG2  THR C   535     F2   BEF C   902              1.32            
REMARK 500   CG2  THR D   535     F3   BEF D   902              1.37            
REMARK 500   O    PRO B   257     O1B  ADP B   904              1.39            
REMARK 500   OD1  ASP G   395     CD1  LEU H    43              1.50            
REMARK 500   OG1  THR C   262     O3A  ADP C   903              1.54            
REMARK 500   NH1  ARG E   369     O2A  ADP E   902              1.54            
REMARK 500   O    GLY B   258     O1A  ADP B   904              1.57            
REMARK 500   O    GLN D   782     NZ   LYS D   785              1.59            
REMARK 500   CB   THR C   262     O3B  ADP C   903              1.60            
REMARK 500   CD   ARG E   645     O2B  ADP E   901              1.60            
REMARK 500   CD1  ILE D   666     N6   ADP E   901              1.65            
REMARK 500   CG2  THR D   535    BE    BEF D   902              1.70            
REMARK 500   CG2  THR C   535    BE    BEF C   902              1.70            
REMARK 500   CG   ASP G   395     CD1  LEU H    43              1.70            
REMARK 500   NE   ARG E   369     O2A  ADP E   902              1.71            
REMARK 500   CD2  LEU C   536     O3'  ADP C   904              1.75            
REMARK 500   OG1  THR C   262     O3B  ADP C   903              1.76            
REMARK 500   CD2  LEU C   536     C3'  ADP C   904              1.77            
REMARK 500   N    THR D   535     O2A  ADP E   901              1.78            
REMARK 500   CZ   ARG E   369     O2A  ADP E   902              1.78            
REMARK 500   NH1  ARG C   369     O2A  ADP B   904              1.85            
REMARK 500   OG1  THR C   262     PB   ADP C   903              1.91            
REMARK 500   CD1  LEU E   263     O3'  ADP E   904              1.92            
REMARK 500   CG2  THR B   262     O3A  ADP B   904              1.93            
REMARK 500   CG2  ILE E   216     C5   ADP E   904              1.94            
REMARK 500   CE1  TYR D   213     CG2  VAL D   268              1.94            
REMARK 500   CB   ALA D   269     CE1  PHE D   276              1.94            
REMARK 500   F1   BEF D   901     O2B  ADP E   902              1.94            
REMARK 500   N    LYS E   534     O1A  ADP E   903              1.97            
REMARK 500   CD   LYS C   766     OE1  GLN D   782              1.97            
REMARK 500   CG2  THR E   535     O3B  ADP E   903              1.97            
REMARK 500   N    THR C   535     O2A  ADP C   904              1.97            
REMARK 500   CD1  LEU B   536     C3'  ADP B   901              1.97            
REMARK 500   CG   LYS C   261     O1B  ADP C   903              1.99            
REMARK 500   O    PRO B   257     PB   ADP B   904              1.99            
REMARK 500   CG2  THR D   262     O3B  ADP E   902              1.99            
REMARK 500   C    GLY B   258     O1A  ADP B   904              2.01            
REMARK 500   N    GLY D   533     O1A  ADP E   901              2.04            
REMARK 500   CB   ALA D   269     CD1  PHE D   276              2.05            
REMARK 500   CD1  LEU D   536     O2'  ADP E   901              2.06            
REMARK 500   N    GLY C   533     O1A  ADP C   904              2.08            
REMARK 500   CG2  THR D   535     F1   BEF D   902              2.09            
REMARK 500   NZ   LYS C   766     CG   GLN D   782              2.11            
REMARK 500   CE   LYS C   766     CG   GLN D   782              2.12            
REMARK 500   F1   BEF D   901     O3B  ADP E   902              2.14            
REMARK 500   CA   GLY B   258     O2B  ADP B   904              2.15            
REMARK 500   CD1  LEU B   536     O3'  ADP B   901              2.15            
REMARK 500   N    THR C   262     O1B  ADP C   903              2.18            
REMARK 500   CG2  THR D   262     F2   BEF D   901              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    CYS B 219   CA  -  CB  -  SG  ANGL. DEV. =   6.8 DEGREES          
REMARK 500    LEU G 508   CA  -  CB  -  CG  ANGL. DEV. =  14.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS B 287       58.29    -90.63                                   
REMARK 500    ARG B 359       73.55     53.34                                   
REMARK 500    ARG B 369      -71.82    -65.91                                   
REMARK 500    PHE B 370      -39.04   -136.27                                   
REMARK 500    THR B 385       18.16     58.22                                   
REMARK 500    LYS B 436       30.76    -95.75                                   
REMARK 500    ASP B 445       57.18     35.99                                   
REMARK 500    ALA B 449      -14.83     69.90                                   
REMARK 500    GLU B 450      -40.07   -137.98                                   
REMARK 500    ASN B 470       75.66     53.44                                   
REMARK 500    PRO B 510       48.93    -87.84                                   
REMARK 500    LYS B 534       -9.57     68.93                                   
REMARK 500    LYS B 553       58.73    -92.97                                   
REMARK 500    PRO B 581      128.80    -36.13                                   
REMARK 500    ALA B 595       -0.18     63.38                                   
REMARK 500    LEU B 671       58.81    -94.41                                   
REMARK 500    THR B 689       59.37    -95.91                                   
REMARK 500    SER C 362       48.49    -92.72                                   
REMARK 500    ASP C 383     -168.87   -119.60                                   
REMARK 500    VAL C 417      -68.14   -109.80                                   
REMARK 500    THR C 485       40.35     37.22                                   
REMARK 500    ALA C 579       53.52    -93.66                                   
REMARK 500    ALA C 593       36.56    -98.14                                   
REMARK 500    ARG C 672       -3.56     65.32                                   
REMARK 500    GLU C 677       78.06     53.26                                   
REMARK 500    THR C 689       57.51     36.95                                   
REMARK 500    PRO C 749       46.37    -87.20                                   
REMARK 500    VAL D 268       66.78   -109.41                                   
REMARK 500    ALA D 269       41.73   -161.26                                   
REMARK 500    ASN D 270      -34.59   -163.63                                   
REMARK 500    ALA D 274     -169.76   -114.70                                   
REMARK 500    LEU D 278      128.61    175.48                                   
REMARK 500    GLU D 291      -10.24     68.06                                   
REMARK 500    ASN D 306       71.28     59.51                                   
REMARK 500    ALA D 320       70.56     51.55                                   
REMARK 500    ASP D 383      -32.54   -130.15                                   
REMARK 500    ASN D 468       55.36     37.16                                   
REMARK 500    ASN D 470       75.98     54.11                                   
REMARK 500    THR D 485     -165.51   -126.24                                   
REMARK 500    TRP D 486       -6.06     75.14                                   
REMARK 500    LEU D 492       54.90    -90.03                                   
REMARK 500    ALA D 580       76.30     54.24                                   
REMARK 500    LYS D 594       70.12     53.48                                   
REMARK 500    ASP D 619      -64.63    -94.25                                   
REMARK 500    GLU D 660      -10.94     72.56                                   
REMARK 500    LEU D 671       32.56    -99.21                                   
REMARK 500    PRO D 749       44.14    -84.59                                   
REMARK 500    VAL D 750       83.24   -155.00                                   
REMARK 500    PRO D 751       45.15    -87.76                                   
REMARK 500    LYS D 755      -75.52    -65.70                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      92 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ALA B  580     PRO B  581                 -127.23                    
REMARK 500 TYR C  562     GLY C  563                 -149.40                    
REMARK 500 ALA E  595     ARG E  596                  139.76                    
REMARK 500 ARG E  596     GLY E  597                 -135.70                    
REMARK 500 LEU E  644     ARG E  645                  145.74                    
REMARK 500 ALA G  512     SER G  513                 -148.87                    
REMARK 500 PRO H   37     PRO H   38                  140.01                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             BEF C 901  BE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ADP C 903   O2B                                                    
REMARK 620 2 BEF C 901   F1   88.1                                              
REMARK 620 3 BEF C 901   F2  133.9 112.6                                        
REMARK 620 4 BEF C 901   F3  103.2 110.4 106.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP B 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF B 902                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF B 903                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP B 904                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF C 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF C 902                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP C 903                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP C 904                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF D 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF D 902                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 902                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 903                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 904                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-0666   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-0665   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-20000   RELATED DB: EMDB                             
DBREF  6OAA B    1   835  UNP    P25694   CDC48_YEAST      1    835             
DBREF  6OAA C    1   835  UNP    P25694   CDC48_YEAST      1    835             
DBREF  6OAA D    1   835  UNP    P25694   CDC48_YEAST      1    835             
DBREF  6OAA E    1   835  UNP    P25694   CDC48_YEAST      1    835             
DBREF  6OAA G    1   580  UNP    P33755   NPL4_YEAST       1    580             
DBREF  6OAA H    1    76  UNP    P0CH08   RL40A_YEAST      1     76             
SEQRES   1 B  835  MET GLY GLU GLU HIS LYS PRO LEU LEU ASP ALA SER GLY          
SEQRES   2 B  835  VAL ASP PRO ARG GLU GLU ASP LYS THR ALA THR ALA ILE          
SEQRES   3 B  835  LEU ARG ARG LYS LYS LYS ASP ASN MET LEU LEU VAL ASP          
SEQRES   4 B  835  ASP ALA ILE ASN ASP ASP ASN SER VAL ILE ALA ILE ASN          
SEQRES   5 B  835  SER ASN THR MET ASP LYS LEU GLU LEU PHE ARG GLY ASP          
SEQRES   6 B  835  THR VAL LEU VAL LYS GLY LYS LYS ARG LYS ASP THR VAL          
SEQRES   7 B  835  LEU ILE VAL LEU ILE ASP ASP GLU LEU GLU ASP GLY ALA          
SEQRES   8 B  835  CYS ARG ILE ASN ARG VAL VAL ARG ASN ASN LEU ARG ILE          
SEQRES   9 B  835  ARG LEU GLY ASP LEU VAL THR ILE HIS PRO CYS PRO ASP          
SEQRES  10 B  835  ILE LYS TYR ALA THR ARG ILE SER VAL LEU PRO ILE ALA          
SEQRES  11 B  835  ASP THR ILE GLU GLY ILE THR GLY ASN LEU PHE ASP VAL          
SEQRES  12 B  835  PHE LEU LYS PRO TYR PHE VAL GLU ALA TYR ARG PRO VAL          
SEQRES  13 B  835  ARG LYS GLY ASP HIS PHE VAL VAL ARG GLY GLY MET ARG          
SEQRES  14 B  835  GLN VAL GLU PHE LYS VAL VAL ASP VAL GLU PRO GLU GLU          
SEQRES  15 B  835  TYR ALA VAL VAL ALA GLN ASP THR ILE ILE HIS TRP GLU          
SEQRES  16 B  835  GLY GLU PRO ILE ASN ARG GLU ASP GLU GLU ASN ASN MET          
SEQRES  17 B  835  ASN GLU VAL GLY TYR ASP ASP ILE GLY GLY CYS ARG LYS          
SEQRES  18 B  835  GLN MET ALA GLN ILE ARG GLU MET VAL GLU LEU PRO LEU          
SEQRES  19 B  835  ARG HIS PRO GLN LEU PHE LYS ALA ILE GLY ILE LYS PRO          
SEQRES  20 B  835  PRO ARG GLY VAL LEU MET TYR GLY PRO PRO GLY THR GLY          
SEQRES  21 B  835  LYS THR LEU MET ALA ARG ALA VAL ALA ASN GLU THR GLY          
SEQRES  22 B  835  ALA PHE PHE PHE LEU ILE ASN GLY PRO GLU VAL MET SER          
SEQRES  23 B  835  LYS MET ALA GLY GLU SER GLU SER ASN LEU ARG LYS ALA          
SEQRES  24 B  835  PHE GLU GLU ALA GLU LYS ASN ALA PRO ALA ILE ILE PHE          
SEQRES  25 B  835  ILE ASP GLU ILE ASP SER ILE ALA PRO LYS ARG ASP LYS          
SEQRES  26 B  835  THR ASN GLY GLU VAL GLU ARG ARG VAL VAL SER GLN LEU          
SEQRES  27 B  835  LEU THR LEU MET ASP GLY MET LYS ALA ARG SER ASN VAL          
SEQRES  28 B  835  VAL VAL ILE ALA ALA THR ASN ARG PRO ASN SER ILE ASP          
SEQRES  29 B  835  PRO ALA LEU ARG ARG PHE GLY ARG PHE ASP ARG GLU VAL          
SEQRES  30 B  835  ASP ILE GLY ILE PRO ASP ALA THR GLY ARG LEU GLU VAL          
SEQRES  31 B  835  LEU ARG ILE HIS THR LYS ASN MET LYS LEU ALA ASP ASP          
SEQRES  32 B  835  VAL ASP LEU GLU ALA LEU ALA ALA GLU THR HIS GLY TYR          
SEQRES  33 B  835  VAL GLY ALA ASP ILE ALA SER LEU CYS SER GLU ALA ALA          
SEQRES  34 B  835  MET GLN GLN ILE ARG GLU LYS MET ASP LEU ILE ASP LEU          
SEQRES  35 B  835  ASP GLU ASP GLU ILE ASP ALA GLU VAL LEU ASP SER LEU          
SEQRES  36 B  835  GLY VAL THR MET ASP ASN PHE ARG PHE ALA LEU GLY ASN          
SEQRES  37 B  835  SER ASN PRO SER ALA LEU ARG GLU THR VAL VAL GLU SER          
SEQRES  38 B  835  VAL ASN VAL THR TRP ASP ASP VAL GLY GLY LEU ASP GLU          
SEQRES  39 B  835  ILE LYS GLU GLU LEU LYS GLU THR VAL GLU TYR PRO VAL          
SEQRES  40 B  835  LEU HIS PRO ASP GLN TYR THR LYS PHE GLY LEU SER PRO          
SEQRES  41 B  835  SER LYS GLY VAL LEU PHE TYR GLY PRO PRO GLY THR GLY          
SEQRES  42 B  835  LYS THR LEU LEU ALA LYS ALA VAL ALA THR GLU VAL SER          
SEQRES  43 B  835  ALA ASN PHE ILE SER VAL LYS GLY PRO GLU LEU LEU SER          
SEQRES  44 B  835  MET TRP TYR GLY GLU SER GLU SER ASN ILE ARG ASP ILE          
SEQRES  45 B  835  PHE ASP LYS ALA ARG ALA ALA ALA PRO THR VAL VAL PHE          
SEQRES  46 B  835  LEU ASP GLU LEU ASP SER ILE ALA LYS ALA ARG GLY GLY          
SEQRES  47 B  835  SER LEU GLY ASP ALA GLY GLY ALA SER ASP ARG VAL VAL          
SEQRES  48 B  835  ASN GLN LEU LEU THR GLU MET ASP GLY MET ASN ALA LYS          
SEQRES  49 B  835  LYS ASN VAL PHE VAL ILE GLY ALA THR ASN ARG PRO ASP          
SEQRES  50 B  835  GLN ILE ASP PRO ALA ILE LEU ARG PRO GLY ARG LEU ASP          
SEQRES  51 B  835  GLN LEU ILE TYR VAL PRO LEU PRO ASP GLU ASN ALA ARG          
SEQRES  52 B  835  LEU SER ILE LEU ASN ALA GLN LEU ARG LYS THR PRO LEU          
SEQRES  53 B  835  GLU PRO GLY LEU GLU LEU THR ALA ILE ALA LYS ALA THR          
SEQRES  54 B  835  GLN GLY PHE SER GLY ALA ASP LEU LEU TYR ILE VAL GLN          
SEQRES  55 B  835  ARG ALA ALA LYS TYR ALA ILE LYS ASP SER ILE GLU ALA          
SEQRES  56 B  835  HIS ARG GLN HIS GLU ALA GLU LYS GLU VAL LYS VAL GLU          
SEQRES  57 B  835  GLY GLU ASP VAL GLU MET THR ASP GLU GLY ALA LYS ALA          
SEQRES  58 B  835  GLU GLN GLU PRO GLU VAL ASP PRO VAL PRO TYR ILE THR          
SEQRES  59 B  835  LYS GLU HIS PHE ALA GLU ALA MET LYS THR ALA LYS ARG          
SEQRES  60 B  835  SER VAL SER ASP ALA GLU LEU ARG ARG TYR GLU ALA TYR          
SEQRES  61 B  835  SER GLN GLN MET LYS ALA SER ARG GLY GLN PHE SER ASN          
SEQRES  62 B  835  PHE ASN PHE ASN ASP ALA PRO LEU GLY THR THR ALA THR          
SEQRES  63 B  835  ASP ASN ALA ASN SER ASN ASN SER ALA PRO SER GLY ALA          
SEQRES  64 B  835  GLY ALA ALA PHE GLY SER ASN ALA GLU GLU ASP ASP ASP          
SEQRES  65 B  835  LEU TYR SER                                                  
SEQRES   1 C  835  MET GLY GLU GLU HIS LYS PRO LEU LEU ASP ALA SER GLY          
SEQRES   2 C  835  VAL ASP PRO ARG GLU GLU ASP LYS THR ALA THR ALA ILE          
SEQRES   3 C  835  LEU ARG ARG LYS LYS LYS ASP ASN MET LEU LEU VAL ASP          
SEQRES   4 C  835  ASP ALA ILE ASN ASP ASP ASN SER VAL ILE ALA ILE ASN          
SEQRES   5 C  835  SER ASN THR MET ASP LYS LEU GLU LEU PHE ARG GLY ASP          
SEQRES   6 C  835  THR VAL LEU VAL LYS GLY LYS LYS ARG LYS ASP THR VAL          
SEQRES   7 C  835  LEU ILE VAL LEU ILE ASP ASP GLU LEU GLU ASP GLY ALA          
SEQRES   8 C  835  CYS ARG ILE ASN ARG VAL VAL ARG ASN ASN LEU ARG ILE          
SEQRES   9 C  835  ARG LEU GLY ASP LEU VAL THR ILE HIS PRO CYS PRO ASP          
SEQRES  10 C  835  ILE LYS TYR ALA THR ARG ILE SER VAL LEU PRO ILE ALA          
SEQRES  11 C  835  ASP THR ILE GLU GLY ILE THR GLY ASN LEU PHE ASP VAL          
SEQRES  12 C  835  PHE LEU LYS PRO TYR PHE VAL GLU ALA TYR ARG PRO VAL          
SEQRES  13 C  835  ARG LYS GLY ASP HIS PHE VAL VAL ARG GLY GLY MET ARG          
SEQRES  14 C  835  GLN VAL GLU PHE LYS VAL VAL ASP VAL GLU PRO GLU GLU          
SEQRES  15 C  835  TYR ALA VAL VAL ALA GLN ASP THR ILE ILE HIS TRP GLU          
SEQRES  16 C  835  GLY GLU PRO ILE ASN ARG GLU ASP GLU GLU ASN ASN MET          
SEQRES  17 C  835  ASN GLU VAL GLY TYR ASP ASP ILE GLY GLY CYS ARG LYS          
SEQRES  18 C  835  GLN MET ALA GLN ILE ARG GLU MET VAL GLU LEU PRO LEU          
SEQRES  19 C  835  ARG HIS PRO GLN LEU PHE LYS ALA ILE GLY ILE LYS PRO          
SEQRES  20 C  835  PRO ARG GLY VAL LEU MET TYR GLY PRO PRO GLY THR GLY          
SEQRES  21 C  835  LYS THR LEU MET ALA ARG ALA VAL ALA ASN GLU THR GLY          
SEQRES  22 C  835  ALA PHE PHE PHE LEU ILE ASN GLY PRO GLU VAL MET SER          
SEQRES  23 C  835  LYS MET ALA GLY GLU SER GLU SER ASN LEU ARG LYS ALA          
SEQRES  24 C  835  PHE GLU GLU ALA GLU LYS ASN ALA PRO ALA ILE ILE PHE          
SEQRES  25 C  835  ILE ASP GLU ILE ASP SER ILE ALA PRO LYS ARG ASP LYS          
SEQRES  26 C  835  THR ASN GLY GLU VAL GLU ARG ARG VAL VAL SER GLN LEU          
SEQRES  27 C  835  LEU THR LEU MET ASP GLY MET LYS ALA ARG SER ASN VAL          
SEQRES  28 C  835  VAL VAL ILE ALA ALA THR ASN ARG PRO ASN SER ILE ASP          
SEQRES  29 C  835  PRO ALA LEU ARG ARG PHE GLY ARG PHE ASP ARG GLU VAL          
SEQRES  30 C  835  ASP ILE GLY ILE PRO ASP ALA THR GLY ARG LEU GLU VAL          
SEQRES  31 C  835  LEU ARG ILE HIS THR LYS ASN MET LYS LEU ALA ASP ASP          
SEQRES  32 C  835  VAL ASP LEU GLU ALA LEU ALA ALA GLU THR HIS GLY TYR          
SEQRES  33 C  835  VAL GLY ALA ASP ILE ALA SER LEU CYS SER GLU ALA ALA          
SEQRES  34 C  835  MET GLN GLN ILE ARG GLU LYS MET ASP LEU ILE ASP LEU          
SEQRES  35 C  835  ASP GLU ASP GLU ILE ASP ALA GLU VAL LEU ASP SER LEU          
SEQRES  36 C  835  GLY VAL THR MET ASP ASN PHE ARG PHE ALA LEU GLY ASN          
SEQRES  37 C  835  SER ASN PRO SER ALA LEU ARG GLU THR VAL VAL GLU SER          
SEQRES  38 C  835  VAL ASN VAL THR TRP ASP ASP VAL GLY GLY LEU ASP GLU          
SEQRES  39 C  835  ILE LYS GLU GLU LEU LYS GLU THR VAL GLU TYR PRO VAL          
SEQRES  40 C  835  LEU HIS PRO ASP GLN TYR THR LYS PHE GLY LEU SER PRO          
SEQRES  41 C  835  SER LYS GLY VAL LEU PHE TYR GLY PRO PRO GLY THR GLY          
SEQRES  42 C  835  LYS THR LEU LEU ALA LYS ALA VAL ALA THR GLU VAL SER          
SEQRES  43 C  835  ALA ASN PHE ILE SER VAL LYS GLY PRO GLU LEU LEU SER          
SEQRES  44 C  835  MET TRP TYR GLY GLU SER GLU SER ASN ILE ARG ASP ILE          
SEQRES  45 C  835  PHE ASP LYS ALA ARG ALA ALA ALA PRO THR VAL VAL PHE          
SEQRES  46 C  835  LEU ASP GLU LEU ASP SER ILE ALA LYS ALA ARG GLY GLY          
SEQRES  47 C  835  SER LEU GLY ASP ALA GLY GLY ALA SER ASP ARG VAL VAL          
SEQRES  48 C  835  ASN GLN LEU LEU THR GLU MET ASP GLY MET ASN ALA LYS          
SEQRES  49 C  835  LYS ASN VAL PHE VAL ILE GLY ALA THR ASN ARG PRO ASP          
SEQRES  50 C  835  GLN ILE ASP PRO ALA ILE LEU ARG PRO GLY ARG LEU ASP          
SEQRES  51 C  835  GLN LEU ILE TYR VAL PRO LEU PRO ASP GLU ASN ALA ARG          
SEQRES  52 C  835  LEU SER ILE LEU ASN ALA GLN LEU ARG LYS THR PRO LEU          
SEQRES  53 C  835  GLU PRO GLY LEU GLU LEU THR ALA ILE ALA LYS ALA THR          
SEQRES  54 C  835  GLN GLY PHE SER GLY ALA ASP LEU LEU TYR ILE VAL GLN          
SEQRES  55 C  835  ARG ALA ALA LYS TYR ALA ILE LYS ASP SER ILE GLU ALA          
SEQRES  56 C  835  HIS ARG GLN HIS GLU ALA GLU LYS GLU VAL LYS VAL GLU          
SEQRES  57 C  835  GLY GLU ASP VAL GLU MET THR ASP GLU GLY ALA LYS ALA          
SEQRES  58 C  835  GLU GLN GLU PRO GLU VAL ASP PRO VAL PRO TYR ILE THR          
SEQRES  59 C  835  LYS GLU HIS PHE ALA GLU ALA MET LYS THR ALA LYS ARG          
SEQRES  60 C  835  SER VAL SER ASP ALA GLU LEU ARG ARG TYR GLU ALA TYR          
SEQRES  61 C  835  SER GLN GLN MET LYS ALA SER ARG GLY GLN PHE SER ASN          
SEQRES  62 C  835  PHE ASN PHE ASN ASP ALA PRO LEU GLY THR THR ALA THR          
SEQRES  63 C  835  ASP ASN ALA ASN SER ASN ASN SER ALA PRO SER GLY ALA          
SEQRES  64 C  835  GLY ALA ALA PHE GLY SER ASN ALA GLU GLU ASP ASP ASP          
SEQRES  65 C  835  LEU TYR SER                                                  
SEQRES   1 D  835  MET GLY GLU GLU HIS LYS PRO LEU LEU ASP ALA SER GLY          
SEQRES   2 D  835  VAL ASP PRO ARG GLU GLU ASP LYS THR ALA THR ALA ILE          
SEQRES   3 D  835  LEU ARG ARG LYS LYS LYS ASP ASN MET LEU LEU VAL ASP          
SEQRES   4 D  835  ASP ALA ILE ASN ASP ASP ASN SER VAL ILE ALA ILE ASN          
SEQRES   5 D  835  SER ASN THR MET ASP LYS LEU GLU LEU PHE ARG GLY ASP          
SEQRES   6 D  835  THR VAL LEU VAL LYS GLY LYS LYS ARG LYS ASP THR VAL          
SEQRES   7 D  835  LEU ILE VAL LEU ILE ASP ASP GLU LEU GLU ASP GLY ALA          
SEQRES   8 D  835  CYS ARG ILE ASN ARG VAL VAL ARG ASN ASN LEU ARG ILE          
SEQRES   9 D  835  ARG LEU GLY ASP LEU VAL THR ILE HIS PRO CYS PRO ASP          
SEQRES  10 D  835  ILE LYS TYR ALA THR ARG ILE SER VAL LEU PRO ILE ALA          
SEQRES  11 D  835  ASP THR ILE GLU GLY ILE THR GLY ASN LEU PHE ASP VAL          
SEQRES  12 D  835  PHE LEU LYS PRO TYR PHE VAL GLU ALA TYR ARG PRO VAL          
SEQRES  13 D  835  ARG LYS GLY ASP HIS PHE VAL VAL ARG GLY GLY MET ARG          
SEQRES  14 D  835  GLN VAL GLU PHE LYS VAL VAL ASP VAL GLU PRO GLU GLU          
SEQRES  15 D  835  TYR ALA VAL VAL ALA GLN ASP THR ILE ILE HIS TRP GLU          
SEQRES  16 D  835  GLY GLU PRO ILE ASN ARG GLU ASP GLU GLU ASN ASN MET          
SEQRES  17 D  835  ASN GLU VAL GLY TYR ASP ASP ILE GLY GLY CYS ARG LYS          
SEQRES  18 D  835  GLN MET ALA GLN ILE ARG GLU MET VAL GLU LEU PRO LEU          
SEQRES  19 D  835  ARG HIS PRO GLN LEU PHE LYS ALA ILE GLY ILE LYS PRO          
SEQRES  20 D  835  PRO ARG GLY VAL LEU MET TYR GLY PRO PRO GLY THR GLY          
SEQRES  21 D  835  LYS THR LEU MET ALA ARG ALA VAL ALA ASN GLU THR GLY          
SEQRES  22 D  835  ALA PHE PHE PHE LEU ILE ASN GLY PRO GLU VAL MET SER          
SEQRES  23 D  835  LYS MET ALA GLY GLU SER GLU SER ASN LEU ARG LYS ALA          
SEQRES  24 D  835  PHE GLU GLU ALA GLU LYS ASN ALA PRO ALA ILE ILE PHE          
SEQRES  25 D  835  ILE ASP GLU ILE ASP SER ILE ALA PRO LYS ARG ASP LYS          
SEQRES  26 D  835  THR ASN GLY GLU VAL GLU ARG ARG VAL VAL SER GLN LEU          
SEQRES  27 D  835  LEU THR LEU MET ASP GLY MET LYS ALA ARG SER ASN VAL          
SEQRES  28 D  835  VAL VAL ILE ALA ALA THR ASN ARG PRO ASN SER ILE ASP          
SEQRES  29 D  835  PRO ALA LEU ARG ARG PHE GLY ARG PHE ASP ARG GLU VAL          
SEQRES  30 D  835  ASP ILE GLY ILE PRO ASP ALA THR GLY ARG LEU GLU VAL          
SEQRES  31 D  835  LEU ARG ILE HIS THR LYS ASN MET LYS LEU ALA ASP ASP          
SEQRES  32 D  835  VAL ASP LEU GLU ALA LEU ALA ALA GLU THR HIS GLY TYR          
SEQRES  33 D  835  VAL GLY ALA ASP ILE ALA SER LEU CYS SER GLU ALA ALA          
SEQRES  34 D  835  MET GLN GLN ILE ARG GLU LYS MET ASP LEU ILE ASP LEU          
SEQRES  35 D  835  ASP GLU ASP GLU ILE ASP ALA GLU VAL LEU ASP SER LEU          
SEQRES  36 D  835  GLY VAL THR MET ASP ASN PHE ARG PHE ALA LEU GLY ASN          
SEQRES  37 D  835  SER ASN PRO SER ALA LEU ARG GLU THR VAL VAL GLU SER          
SEQRES  38 D  835  VAL ASN VAL THR TRP ASP ASP VAL GLY GLY LEU ASP GLU          
SEQRES  39 D  835  ILE LYS GLU GLU LEU LYS GLU THR VAL GLU TYR PRO VAL          
SEQRES  40 D  835  LEU HIS PRO ASP GLN TYR THR LYS PHE GLY LEU SER PRO          
SEQRES  41 D  835  SER LYS GLY VAL LEU PHE TYR GLY PRO PRO GLY THR GLY          
SEQRES  42 D  835  LYS THR LEU LEU ALA LYS ALA VAL ALA THR GLU VAL SER          
SEQRES  43 D  835  ALA ASN PHE ILE SER VAL LYS GLY PRO GLU LEU LEU SER          
SEQRES  44 D  835  MET TRP TYR GLY GLU SER GLU SER ASN ILE ARG ASP ILE          
SEQRES  45 D  835  PHE ASP LYS ALA ARG ALA ALA ALA PRO THR VAL VAL PHE          
SEQRES  46 D  835  LEU ASP GLU LEU ASP SER ILE ALA LYS ALA ARG GLY GLY          
SEQRES  47 D  835  SER LEU GLY ASP ALA GLY GLY ALA SER ASP ARG VAL VAL          
SEQRES  48 D  835  ASN GLN LEU LEU THR GLU MET ASP GLY MET ASN ALA LYS          
SEQRES  49 D  835  LYS ASN VAL PHE VAL ILE GLY ALA THR ASN ARG PRO ASP          
SEQRES  50 D  835  GLN ILE ASP PRO ALA ILE LEU ARG PRO GLY ARG LEU ASP          
SEQRES  51 D  835  GLN LEU ILE TYR VAL PRO LEU PRO ASP GLU ASN ALA ARG          
SEQRES  52 D  835  LEU SER ILE LEU ASN ALA GLN LEU ARG LYS THR PRO LEU          
SEQRES  53 D  835  GLU PRO GLY LEU GLU LEU THR ALA ILE ALA LYS ALA THR          
SEQRES  54 D  835  GLN GLY PHE SER GLY ALA ASP LEU LEU TYR ILE VAL GLN          
SEQRES  55 D  835  ARG ALA ALA LYS TYR ALA ILE LYS ASP SER ILE GLU ALA          
SEQRES  56 D  835  HIS ARG GLN HIS GLU ALA GLU LYS GLU VAL LYS VAL GLU          
SEQRES  57 D  835  GLY GLU ASP VAL GLU MET THR ASP GLU GLY ALA LYS ALA          
SEQRES  58 D  835  GLU GLN GLU PRO GLU VAL ASP PRO VAL PRO TYR ILE THR          
SEQRES  59 D  835  LYS GLU HIS PHE ALA GLU ALA MET LYS THR ALA LYS ARG          
SEQRES  60 D  835  SER VAL SER ASP ALA GLU LEU ARG ARG TYR GLU ALA TYR          
SEQRES  61 D  835  SER GLN GLN MET LYS ALA SER ARG GLY GLN PHE SER ASN          
SEQRES  62 D  835  PHE ASN PHE ASN ASP ALA PRO LEU GLY THR THR ALA THR          
SEQRES  63 D  835  ASP ASN ALA ASN SER ASN ASN SER ALA PRO SER GLY ALA          
SEQRES  64 D  835  GLY ALA ALA PHE GLY SER ASN ALA GLU GLU ASP ASP ASP          
SEQRES  65 D  835  LEU TYR SER                                                  
SEQRES   1 E  835  MET GLY GLU GLU HIS LYS PRO LEU LEU ASP ALA SER GLY          
SEQRES   2 E  835  VAL ASP PRO ARG GLU GLU ASP LYS THR ALA THR ALA ILE          
SEQRES   3 E  835  LEU ARG ARG LYS LYS LYS ASP ASN MET LEU LEU VAL ASP          
SEQRES   4 E  835  ASP ALA ILE ASN ASP ASP ASN SER VAL ILE ALA ILE ASN          
SEQRES   5 E  835  SER ASN THR MET ASP LYS LEU GLU LEU PHE ARG GLY ASP          
SEQRES   6 E  835  THR VAL LEU VAL LYS GLY LYS LYS ARG LYS ASP THR VAL          
SEQRES   7 E  835  LEU ILE VAL LEU ILE ASP ASP GLU LEU GLU ASP GLY ALA          
SEQRES   8 E  835  CYS ARG ILE ASN ARG VAL VAL ARG ASN ASN LEU ARG ILE          
SEQRES   9 E  835  ARG LEU GLY ASP LEU VAL THR ILE HIS PRO CYS PRO ASP          
SEQRES  10 E  835  ILE LYS TYR ALA THR ARG ILE SER VAL LEU PRO ILE ALA          
SEQRES  11 E  835  ASP THR ILE GLU GLY ILE THR GLY ASN LEU PHE ASP VAL          
SEQRES  12 E  835  PHE LEU LYS PRO TYR PHE VAL GLU ALA TYR ARG PRO VAL          
SEQRES  13 E  835  ARG LYS GLY ASP HIS PHE VAL VAL ARG GLY GLY MET ARG          
SEQRES  14 E  835  GLN VAL GLU PHE LYS VAL VAL ASP VAL GLU PRO GLU GLU          
SEQRES  15 E  835  TYR ALA VAL VAL ALA GLN ASP THR ILE ILE HIS TRP GLU          
SEQRES  16 E  835  GLY GLU PRO ILE ASN ARG GLU ASP GLU GLU ASN ASN MET          
SEQRES  17 E  835  ASN GLU VAL GLY TYR ASP ASP ILE GLY GLY CYS ARG LYS          
SEQRES  18 E  835  GLN MET ALA GLN ILE ARG GLU MET VAL GLU LEU PRO LEU          
SEQRES  19 E  835  ARG HIS PRO GLN LEU PHE LYS ALA ILE GLY ILE LYS PRO          
SEQRES  20 E  835  PRO ARG GLY VAL LEU MET TYR GLY PRO PRO GLY THR GLY          
SEQRES  21 E  835  LYS THR LEU MET ALA ARG ALA VAL ALA ASN GLU THR GLY          
SEQRES  22 E  835  ALA PHE PHE PHE LEU ILE ASN GLY PRO GLU VAL MET SER          
SEQRES  23 E  835  LYS MET ALA GLY GLU SER GLU SER ASN LEU ARG LYS ALA          
SEQRES  24 E  835  PHE GLU GLU ALA GLU LYS ASN ALA PRO ALA ILE ILE PHE          
SEQRES  25 E  835  ILE ASP GLU ILE ASP SER ILE ALA PRO LYS ARG ASP LYS          
SEQRES  26 E  835  THR ASN GLY GLU VAL GLU ARG ARG VAL VAL SER GLN LEU          
SEQRES  27 E  835  LEU THR LEU MET ASP GLY MET LYS ALA ARG SER ASN VAL          
SEQRES  28 E  835  VAL VAL ILE ALA ALA THR ASN ARG PRO ASN SER ILE ASP          
SEQRES  29 E  835  PRO ALA LEU ARG ARG PHE GLY ARG PHE ASP ARG GLU VAL          
SEQRES  30 E  835  ASP ILE GLY ILE PRO ASP ALA THR GLY ARG LEU GLU VAL          
SEQRES  31 E  835  LEU ARG ILE HIS THR LYS ASN MET LYS LEU ALA ASP ASP          
SEQRES  32 E  835  VAL ASP LEU GLU ALA LEU ALA ALA GLU THR HIS GLY TYR          
SEQRES  33 E  835  VAL GLY ALA ASP ILE ALA SER LEU CYS SER GLU ALA ALA          
SEQRES  34 E  835  MET GLN GLN ILE ARG GLU LYS MET ASP LEU ILE ASP LEU          
SEQRES  35 E  835  ASP GLU ASP GLU ILE ASP ALA GLU VAL LEU ASP SER LEU          
SEQRES  36 E  835  GLY VAL THR MET ASP ASN PHE ARG PHE ALA LEU GLY ASN          
SEQRES  37 E  835  SER ASN PRO SER ALA LEU ARG GLU THR VAL VAL GLU SER          
SEQRES  38 E  835  VAL ASN VAL THR TRP ASP ASP VAL GLY GLY LEU ASP GLU          
SEQRES  39 E  835  ILE LYS GLU GLU LEU LYS GLU THR VAL GLU TYR PRO VAL          
SEQRES  40 E  835  LEU HIS PRO ASP GLN TYR THR LYS PHE GLY LEU SER PRO          
SEQRES  41 E  835  SER LYS GLY VAL LEU PHE TYR GLY PRO PRO GLY THR GLY          
SEQRES  42 E  835  LYS THR LEU LEU ALA LYS ALA VAL ALA THR GLU VAL SER          
SEQRES  43 E  835  ALA ASN PHE ILE SER VAL LYS GLY PRO GLU LEU LEU SER          
SEQRES  44 E  835  MET TRP TYR GLY GLU SER GLU SER ASN ILE ARG ASP ILE          
SEQRES  45 E  835  PHE ASP LYS ALA ARG ALA ALA ALA PRO THR VAL VAL PHE          
SEQRES  46 E  835  LEU ASP GLU LEU ASP SER ILE ALA LYS ALA ARG GLY GLY          
SEQRES  47 E  835  SER LEU GLY ASP ALA GLY GLY ALA SER ASP ARG VAL VAL          
SEQRES  48 E  835  ASN GLN LEU LEU THR GLU MET ASP GLY MET ASN ALA LYS          
SEQRES  49 E  835  LYS ASN VAL PHE VAL ILE GLY ALA THR ASN ARG PRO ASP          
SEQRES  50 E  835  GLN ILE ASP PRO ALA ILE LEU ARG PRO GLY ARG LEU ASP          
SEQRES  51 E  835  GLN LEU ILE TYR VAL PRO LEU PRO ASP GLU ASN ALA ARG          
SEQRES  52 E  835  LEU SER ILE LEU ASN ALA GLN LEU ARG LYS THR PRO LEU          
SEQRES  53 E  835  GLU PRO GLY LEU GLU LEU THR ALA ILE ALA LYS ALA THR          
SEQRES  54 E  835  GLN GLY PHE SER GLY ALA ASP LEU LEU TYR ILE VAL GLN          
SEQRES  55 E  835  ARG ALA ALA LYS TYR ALA ILE LYS ASP SER ILE GLU ALA          
SEQRES  56 E  835  HIS ARG GLN HIS GLU ALA GLU LYS GLU VAL LYS VAL GLU          
SEQRES  57 E  835  GLY GLU ASP VAL GLU MET THR ASP GLU GLY ALA LYS ALA          
SEQRES  58 E  835  GLU GLN GLU PRO GLU VAL ASP PRO VAL PRO TYR ILE THR          
SEQRES  59 E  835  LYS GLU HIS PHE ALA GLU ALA MET LYS THR ALA LYS ARG          
SEQRES  60 E  835  SER VAL SER ASP ALA GLU LEU ARG ARG TYR GLU ALA TYR          
SEQRES  61 E  835  SER GLN GLN MET LYS ALA SER ARG GLY GLN PHE SER ASN          
SEQRES  62 E  835  PHE ASN PHE ASN ASP ALA PRO LEU GLY THR THR ALA THR          
SEQRES  63 E  835  ASP ASN ALA ASN SER ASN ASN SER ALA PRO SER GLY ALA          
SEQRES  64 E  835  GLY ALA ALA PHE GLY SER ASN ALA GLU GLU ASP ASP ASP          
SEQRES  65 E  835  LEU TYR SER                                                  
SEQRES   1 G  580  MET LEU ILE ARG PHE ARG SER LYS ASN GLY THR HIS ARG          
SEQRES   2 G  580  VAL SER CYS GLN GLU ASN ASP LEU PHE GLY THR VAL ILE          
SEQRES   3 G  580  GLU LYS LEU VAL GLY ASN LEU ASP PRO ASN ALA ASP VAL          
SEQRES   4 G  580  ASP THR PHE THR VAL CYS GLU LYS PRO GLY GLN GLY ILE          
SEQRES   5 G  580  HIS ALA VAL SER GLU LEU ALA ASP ARG THR VAL MET ASP          
SEQRES   6 G  580  LEU GLY LEU LYS HIS GLY ASP MET LEU ILE LEU ASN TYR          
SEQRES   7 G  580  SER ASP LYS PRO ALA ASN GLU LYS ASP GLY VAL ASN VAL          
SEQRES   8 G  580  GLU ILE GLY SER VAL GLY ILE ASP SER LYS GLY ILE ARG          
SEQRES   9 G  580  GLN HIS ARG TYR GLY PRO LEU ARG ILE LYS GLU LEU ALA          
SEQRES  10 G  580  VAL ASP GLU GLU LEU GLU LYS GLU ASP GLY LEU ILE PRO          
SEQRES  11 G  580  ARG GLN LYS SER LYS LEU CYS LYS HIS GLY ASP ARG GLY          
SEQRES  12 G  580  MET CYS GLU TYR CYS SER PRO LEU PRO PRO TRP ASP LYS          
SEQRES  13 G  580  GLU TYR HIS GLU LYS ASN LYS ILE LYS HIS ILE SER PHE          
SEQRES  14 G  580  HIS SER TYR LEU LYS LYS LEU ASN GLU ASN ALA ASN LYS          
SEQRES  15 G  580  LYS GLU ASN GLY SER SER TYR ILE SER PRO LEU SER GLU          
SEQRES  16 G  580  PRO ASP PHE ARG ILE ASN LYS ARG CYS HIS ASN GLY HIS          
SEQRES  17 G  580  GLU PRO TRP PRO ARG GLY ILE CYS SER LYS CYS GLN PRO          
SEQRES  18 G  580  SER ALA ILE THR LEU GLN GLN GLN GLU PHE ARG MET VAL          
SEQRES  19 G  580  ASP HIS VAL GLU PHE GLN LYS SER GLU ILE ILE ASN GLU          
SEQRES  20 G  580  PHE ILE GLN ALA TRP ARG TYR THR GLY MET GLN ARG PHE          
SEQRES  21 G  580  GLY TYR MET TYR GLY SER TYR SER LYS TYR ASP ASN THR          
SEQRES  22 G  580  PRO LEU GLY ILE LYS ALA VAL VAL GLU ALA ILE TYR GLU          
SEQRES  23 G  580  PRO PRO GLN HIS ASP GLU GLN ASP GLY LEU THR MET ASP          
SEQRES  24 G  580  VAL GLU GLN VAL LYS ASN GLU MET LEU GLN ILE ASP ARG          
SEQRES  25 G  580  GLN ALA GLN GLU MET GLY LEU SER ARG ILE GLY LEU ILE          
SEQRES  26 G  580  PHE THR ASP LEU SER ASP ALA GLY ALA GLY ASP GLY SER          
SEQRES  27 G  580  VAL PHE CYS LYS ARG HIS LYS ASP SER PHE PHE LEU SER          
SEQRES  28 G  580  SER LEU GLU VAL ILE MET ALA ALA ARG HIS GLN THR ARG          
SEQRES  29 G  580  HIS PRO ASN VAL SER LYS TYR SER GLU GLN GLY PHE PHE          
SEQRES  30 G  580  SER SER LYS PHE VAL THR CYS VAL ILE SER GLY ASN LEU          
SEQRES  31 G  580  GLU GLY GLU ILE ASP ILE SER SER TYR GLN VAL SER THR          
SEQRES  32 G  580  GLU ALA GLU ALA LEU VAL THR ALA ASP MET ILE SER GLY          
SEQRES  33 G  580  SER THR PHE PRO SER MET ALA TYR ILE ASN ASP THR THR          
SEQRES  34 G  580  ASP GLU ARG TYR VAL PRO GLU ILE PHE TYR MET LYS SER          
SEQRES  35 G  580  ASN GLU TYR GLY ILE THR VAL LYS GLU ASN ALA LYS PRO          
SEQRES  36 G  580  ALA PHE PRO VAL ASP TYR LEU LEU VAL THR LEU THR HIS          
SEQRES  37 G  580  GLY PHE PRO ASN THR ASP THR GLU THR ASN SER LYS PHE          
SEQRES  38 G  580  VAL SER SER THR GLY PHE PRO TRP SER ASN ARG GLN ALA          
SEQRES  39 G  580  MET GLY GLN SER GLN ASP TYR GLN GLU LEU LYS LYS TYR          
SEQRES  40 G  580  LEU PHE ASN VAL ALA SER SER GLY ASP PHE ASN LEU LEU          
SEQRES  41 G  580  HIS GLU LYS ILE SER ASN PHE HIS LEU LEU LEU TYR ILE          
SEQRES  42 G  580  ASN SER LEU GLN ILE LEU SER PRO ASP GLU TRP LYS LEU          
SEQRES  43 G  580  LEU ILE GLU SER ALA VAL LYS ASN GLU TRP GLU GLU SER          
SEQRES  44 G  580  LEU LEU LYS LEU VAL SER SER ALA GLY TRP GLN THR LEU          
SEQRES  45 G  580  VAL MET ILE LEU GLN GLU SER GLY                              
SEQRES   1 H   76  MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE          
SEQRES   2 H   76  THR LEU GLU VAL GLU SER SER ASP THR ILE ASP ASN VAL          
SEQRES   3 H   76  LYS SER LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP          
SEQRES   4 H   76  GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP          
SEQRES   5 H   76  GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER          
SEQRES   6 H   76  THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY                  
HET    ADP  B 901      27                                                       
HET    BEF  B 902       4                                                       
HET    BEF  B 903       4                                                       
HET    ADP  B 904      27                                                       
HET    BEF  C 901       4                                                       
HET    BEF  C 902       4                                                       
HET    ADP  C 903      27                                                       
HET    ADP  C 904      27                                                       
HET    BEF  D 901       4                                                       
HET    BEF  D 902       4                                                       
HET    ADP  E 901      27                                                       
HET    ADP  E 902      27                                                       
HET    ADP  E 903      27                                                       
HET    ADP  E 904      27                                                       
HETNAM     ADP ADENOSINE-5'-DIPHOSPHATE                                         
HETNAM     BEF BERYLLIUM TRIFLUORIDE ION                                        
FORMUL   7  ADP    8(C10 H15 N5 O10 P2)                                         
FORMUL   8  BEF    6(BE F3 1-)                                                  
HELIX    1 AA1 CYS B  219  GLU B  228  1                                  10    
HELIX    2 AA2 GLU B  231  HIS B  236  1                                   6    
HELIX    3 AA3 LYS B  261  THR B  272  1                                  12    
HELIX    4 AA4 LEU B  296  LYS B  305  1                                  10    
HELIX    5 AA5 VAL B  330  MET B  345  1                                  16    
HELIX    6 AA6 ARG B  359  ILE B  363  5                                   5    
HELIX    7 AA7 ASP B  364  ARG B  369  5                                   6    
HELIX    8 AA8 GLY B  386  THR B  395  1                                  10    
HELIX    9 AA9 ASP B  405  THR B  413  1                                   9    
HELIX   10 AB1 GLY B  418  LYS B  436  1                                  19    
HELIX   11 AB2 THR B  458  ASN B  468  1                                  11    
HELIX   12 AB3 GLU B  494  HIS B  509  1                                  16    
HELIX   13 AB4 ASP B  511  GLY B  517  1                                   7    
HELIX   14 AB5 LEU B  536  GLU B  544  1                                   9    
HELIX   15 AB6 GLY B  563  ASN B  568  1                                   6    
HELIX   16 AB7 ASP B  571  ALA B  579  1                                   9    
HELIX   17 AB8 LEU B  589  LYS B  594  1                                   6    
HELIX   18 AB9 ALA B  595  GLY B  597  5                                   3    
HELIX   19 AC1 ASP B  608  GLY B  620  1                                  13    
HELIX   20 AC2 ASP B  659  LEU B  671  1                                  13    
HELIX   21 AC3 LEU B  682  THR B  689  1                                   8    
HELIX   22 AC4 ALA B  695  HIS B  716  1                                  22    
HELIX   23 AC5 CYS C  219  GLU C  231  1                                  13    
HELIX   24 AC6 GLU C  231  HIS C  236  1                                   6    
HELIX   25 AC7 GLU C  293  GLU C  304  1                                  12    
HELIX   26 AC8 VAL C  330  ASP C  343  1                                  14    
HELIX   27 AC9 ASP C  364  ARG C  369  5                                   6    
HELIX   28 AD1 ARG C  387  HIS C  394  1                                   8    
HELIX   29 AD2 ASP C  405  GLU C  412  1                                   8    
HELIX   30 AD3 ALA C  419  LYS C  436  1                                  18    
HELIX   31 AD4 ASP C  460  LEU C  466  1                                   7    
HELIX   32 AD5 LEU C  492  HIS C  509  1                                  18    
HELIX   33 AD6 HIS C  509  GLY C  517  1                                   9    
HELIX   34 AD7 LEU C  537  ALA C  542  1                                   6    
HELIX   35 AD8 GLY C  563  ALA C  579  1                                  17    
HELIX   36 AD9 ASP C  608  ASP C  619  1                                  12    
HELIX   37 AE1 ASN C  661  ARG C  672  1                                  12    
HELIX   38 AE2 LEU C  682  ALA C  688  1                                   7    
HELIX   39 AE3 ALA C  695  ASP C  711  1                                  17    
HELIX   40 AE4 THR C  754  GLU C  760  1                                   7    
HELIX   41 AE5 SER C  770  ALA C  779  1                                  10    
HELIX   42 AE6 ARG D  220  GLU D  231  1                                  12    
HELIX   43 AE7 GLU D  231  HIS D  236  1                                   6    
HELIX   44 AE8 LEU D  263  VAL D  268  1                                   6    
HELIX   45 AE9 GLY D  281  MET D  285  5                                   5    
HELIX   46 AF1 GLU D  293  GLU D  302  1                                  10    
HELIX   47 AF2 GLY D  328  LEU D  341  1                                  14    
HELIX   48 AF3 ASP D  364  ARG D  368  5                                   5    
HELIX   49 AF4 ARG D  387  ARG D  392  1                                   6    
HELIX   50 AF5 GLU D  407  GLU D  412  5                                   6    
HELIX   51 AF6 GLY D  418  LYS D  436  1                                  19    
HELIX   52 AF7 THR D  458  GLY D  467  1                                  10    
HELIX   53 AF8 PRO D  471  ARG D  475  5                                   5    
HELIX   54 AF9 LEU D  492  GLU D  504  1                                  13    
HELIX   55 AG1 GLU D  504  HIS D  509  1                                   6    
HELIX   56 AG2 PRO D  510  GLY D  517  1                                   8    
HELIX   57 AG3 THR D  535  VAL D  545  1                                  11    
HELIX   58 AG4 ILE D  569  ALA D  580  1                                  12    
HELIX   59 AG5 GLU D  588  LYS D  594  1                                   7    
HELIX   60 AG6 ASP D  608  ASP D  619  1                                  12    
HELIX   61 AG7 ARG D  635  ILE D  639  5                                   5    
HELIX   62 AG8 ASN D  661  LEU D  671  1                                  11    
HELIX   63 AG9 LEU D  682  THR D  689  1                                   8    
HELIX   64 AH1 SER D  693  LEU D  698  1                                   6    
HELIX   65 AH2 VAL D  701  ALA D  708  1                                   8    
HELIX   66 AH3 SER D  712  HIS D  716  5                                   5    
HELIX   67 AH4 SER D  770  GLU D  778  1                                   9    
HELIX   68 AH5 ARG E  220  GLU E  228  1                                   9    
HELIX   69 AH6 VAL E  230  HIS E  236  1                                   7    
HELIX   70 AH7 LYS E  261  GLY E  273  1                                  13    
HELIX   71 AH8 LEU E  296  ALA E  303  1                                   8    
HELIX   72 AH9 GLY E  328  ASP E  343  1                                  16    
HELIX   73 AI1 ASP E  364  ARG E  368  5                                   5    
HELIX   74 AI2 ARG E  387  THR E  395  1                                   9    
HELIX   75 AI3 ASP E  405  THR E  413  1                                   9    
HELIX   76 AI4 ALA E  419  LYS E  436  1                                  18    
HELIX   77 AI5 THR E  458  ASN E  468  1                                  11    
HELIX   78 AI6 LEU E  492  VAL E  503  1                                  12    
HELIX   79 AI7 HIS E  509  GLY E  517  1                                   9    
HELIX   80 AI8 GLY E  533  VAL E  545  1                                  13    
HELIX   81 AI9 GLY E  563  ALA E  579  1                                  17    
HELIX   82 AJ1 GLU E  588  ILE E  592  5                                   5    
HELIX   83 AJ2 ASP E  608  GLU E  617  1                                  10    
HELIX   84 AJ3 ASP E  659  ASN E  668  1                                  10    
HELIX   85 AJ4 ALA G  117  GLU G  125  1                                   9    
HELIX   86 AJ5 ASP G  155  GLU G  160  1                                   6    
HELIX   87 AJ6 PHE G  169  LEU G  176  1                                   8    
HELIX   88 AJ7 CYS G  216  GLN G  220  5                                   5    
HELIX   89 AJ8 LYS G  241  GLY G  256  1                                  16    
HELIX   90 AJ9 VAL G  300  GLN G  313  1                                  14    
HELIX   91 AK1 SER G  351  ARG G  364  1                                  14    
HELIX   92 AK2 ASP G  500  LEU G  508  1                                   9    
HELIX   93 AK3 PHE G  517  SER G  525  1                                   9    
HELIX   94 AK4 ASN G  526  LEU G  536  1                                  11    
HELIX   95 AK5 SER G  540  SER G  550  1                                  11    
HELIX   96 AK6 TRP G  556  SER G  565  1                                  10    
HELIX   97 AK7 SER G  566  SER G  579  1                                  14    
HELIX   98 AK8 ASP H   24  ILE H   30  1                                   7    
SHEET    1 AA1 5 PHE B 277  ILE B 279  0                                        
SHEET    2 AA1 5 ILE B 311  ASP B 314  1  O  ASP B 314   N  ILE B 279           
SHEET    3 AA1 5 ALA B 355  ALA B 356  1  O  ALA B 356   N  ILE B 313           
SHEET    4 AA1 5 LEU B 252  TYR B 254  1  N  MET B 253   O  ALA B 355           
SHEET    5 AA1 5 VAL B 377  ASP B 378  1  O  VAL B 377   N  LEU B 252           
SHEET    1 AA2 5 PHE B 549  VAL B 552  0                                        
SHEET    2 AA2 5 VAL B 583  ASP B 587  1  O  PHE B 585   N  ILE B 550           
SHEET    3 AA2 5 PHE B 628  ALA B 632  1  O  ILE B 630   N  LEU B 586           
SHEET    4 AA2 5 VAL B 524  TYR B 527  1  N  PHE B 526   O  GLY B 631           
SHEET    5 AA2 5 GLN B 651  TYR B 654  1  O  GLN B 651   N  LEU B 525           
SHEET    1 AA3 4 LEU C 252  MET C 253  0                                        
SHEET    2 AA3 4 VAL C 352  ALA C 356  1  O  ALA C 355   N  MET C 253           
SHEET    3 AA3 4 ALA C 309  ASP C 314  1  N  ILE C 311   O  ILE C 354           
SHEET    4 AA3 4 PHE C 275  ILE C 279  1  N  PHE C 275   O  ILE C 310           
SHEET    1 AA4 5 ASN C 548  LYS C 553  0                                        
SHEET    2 AA4 5 THR C 582  ASP C 587  1  O  VAL C 583   N  ASN C 548           
SHEET    3 AA4 5 VAL C 627  ALA C 632  1  O  ILE C 630   N  LEU C 586           
SHEET    4 AA4 5 VAL C 524  PHE C 526  1  N  VAL C 524   O  VAL C 629           
SHEET    5 AA4 5 GLN C 651  ILE C 653  1  O  GLN C 651   N  LEU C 525           
SHEET    1 AA5 4 ILE D 311  PHE D 312  0                                        
SHEET    2 AA5 4 VAL D 353  ALA D 356  1  O  ILE D 354   N  ILE D 311           
SHEET    3 AA5 4 GLY D 250  TYR D 254  1  N  VAL D 251   O  ALA D 355           
SHEET    4 AA5 4 VAL D 377  ASP D 378  1  O  VAL D 377   N  TYR D 254           
SHEET    1 AA6 4 VAL D 524  PHE D 526  0                                        
SHEET    2 AA6 4 VAL D 629  ALA D 632  1  O  GLY D 631   N  PHE D 526           
SHEET    3 AA6 4 THR D 582  ASP D 587  1  N  LEU D 586   O  ILE D 630           
SHEET    4 AA6 4 ASN D 548  VAL D 552  1  N  ILE D 550   O  PHE D 585           
SHEET    1 AA7 4 ILE E 313  ASP E 314  0                                        
SHEET    2 AA7 4 VAL E 353  THR E 357  1  O  ALA E 356   N  ILE E 313           
SHEET    3 AA7 4 GLY E 250  TYR E 254  1  N  VAL E 251   O  ALA E 355           
SHEET    4 AA7 4 ARG E 375  ASP E 378  1  O  VAL E 377   N  LEU E 252           
SHEET    1 AA8 2 PHE E 275  PHE E 276  0                                        
SHEET    2 AA8 2 ALA E 309  ILE E 310  1  O  ILE E 310   N  PHE E 275           
SHEET    1 AA9 5 ASN E 548  SER E 551  0                                        
SHEET    2 AA9 5 THR E 582  LEU E 586  1  O  VAL E 583   N  ILE E 550           
SHEET    3 AA9 5 VAL E 627  THR E 633  1  O  ILE E 630   N  LEU E 586           
SHEET    4 AA9 5 GLY E 523  TYR E 527  1  N  VAL E 524   O  GLY E 631           
SHEET    5 AA9 5 GLN E 651  LEU E 652  1  O  GLN E 651   N  LEU E 525           
SHEET    1 AB1 7 HIS G 236  GLU G 238  0                                        
SHEET    2 AB1 7 GLY G 276  TYR G 285  1  O  ALA G 279   N  GLU G 238           
SHEET    3 AB1 7 PHE G 260  TYR G 270 -1  N  TYR G 264   O  GLU G 282           
SHEET    4 AB1 7 SER G 320  THR G 327 -1  O  ILE G 325   N  GLY G 261           
SHEET    5 AB1 7 VAL G 382  ILE G 386  1  O  CYS G 384   N  LEU G 324           
SHEET    6 AB1 7 ILE G 396  VAL G 401 -1  O  SER G 397   N  VAL G 385           
SHEET    7 AB1 7 LEU G 463  THR G 465 -1  O  VAL G 464   N  GLN G 400           
SHEET    1 AB2 2 ILE G 414  SER G 415  0                                        
SHEET    2 AB2 2 TYR G 424  ILE G 425 -1  O  TYR G 424   N  SER G 415           
LINK        BE   BEF C 901                 O2B ADP C 903     1555   1555  1.72  
CISPEP   1 ALA B  307    PRO B  308          0         1.81                     
CISPEP   2 ALA C  307    PRO C  308          0        -0.09                     
CISPEP   3 GLU C  480    SER C  481          0        -8.34                     
CISPEP   4 ALA C  580    PRO C  581          0        -1.79                     
CISPEP   5 GLY C  598    SER C  599          0        -1.63                     
CISPEP   6 ALA D  307    PRO D  308          0         3.17                     
CISPEP   7 ALA D  580    PRO D  581          0         2.37                     
CISPEP   8 ALA E  307    PRO E  308          0        -0.53                     
CISPEP   9 GLU E  480    SER E  481          0        -4.99                     
CISPEP  10 ALA E  580    PRO E  581          0         1.50                     
SITE     1 AC1 13 VAL B 489  PRO B 530  GLY B 531  GLY B 533                    
SITE     2 AC1 13 LYS B 534  THR B 535  LEU B 536  ILE B 666                    
SITE     3 AC1 13 GLN B 670  GLY B 694  BEF B 903  ARG C 645                    
SITE     4 AC1 13 ARG C 648                                                     
SITE     1 AC2  4 THR B 262  ASP B 314  GLU B 315  ADP B 904                    
SITE     1 AC3  5 THR B 535  ASP B 587  GLU B 588  ADP B 901                    
SITE     2 AC3  5 ARG C 648                                                     
SITE     1 AC4 15 ILE B 216  GLY B 217  PRO B 257  GLY B 258                    
SITE     2 AC4 15 THR B 259  LYS B 261  THR B 262  LEU B 263                    
SITE     3 AC4 15 VAL B 390  GLY B 418  ALA B 419  ALA B 422                    
SITE     4 AC4 15 BEF B 902  ARG C 369  PHE C 370                               
SITE     1 AC5  6 LYS C 261  THR C 262  GLU C 315  ADP C 903                    
SITE     2 AC5  6 ASP D 343  ARG D 372                                          
SITE     1 AC6  5 THR C 535  ASP C 587  GLU C 588  ADP C 904                    
SITE     2 AC6  5 ARG D 648                                                     
SITE     1 AC7 13 ILE C 216  GLY C 217  THR C 259  GLY C 260                    
SITE     2 AC7 13 LYS C 261  THR C 262  LEU C 263  HIS C 394                    
SITE     3 AC7 13 GLY C 418  BEF C 901  ASP D 343  ARG D 369                    
SITE     4 AC7 13 PHE D 370                                                     
SITE     1 AC8 14 PRO C 530  GLY C 531  THR C 532  GLY C 533                    
SITE     2 AC8 14 LYS C 534  THR C 535  LEU C 536  ILE C 666                    
SITE     3 AC8 14 GLY C 694  ALA C 695  LEU C 698  BEF C 902                    
SITE     4 AC8 14 ASP D 619  ARG D 645                                          
SITE     1 AC9  4 LYS D 261  THR D 262  ARG E 369  ADP E 902                    
SITE     1 AD1  6 THR D 535  ASP D 587  ALA D 632  ASP E 619                    
SITE     2 AD1  6 ARG E 648  ADP E 901                                          
SITE     1 AD2 13 PRO D 530  GLY D 531  THR D 532  GLY D 533                    
SITE     2 AD2 13 LYS D 534  THR D 535  LEU D 536  ILE D 666                    
SITE     3 AD2 13 GLN D 670  GLY D 694  BEF D 902  ARG E 645                    
SITE     4 AD2 13 ARG E 648                                                     
SITE     1 AD3 12 ILE D 216  GLY D 258  THR D 259  GLY D 260                    
SITE     2 AD3 12 LYS D 261  THR D 262  LEU D 263  VAL D 390                    
SITE     3 AD3 12 GLY D 418  BEF D 901  ARG E 369  PHE E 370                    
SITE     1 AD4  8 GLY E 531  THR E 532  GLY E 533  LYS E 534                    
SITE     2 AD4  8 THR E 535  LEU E 536  PRO E 658  GLN E 670                    
SITE     1 AD5 10 ASP E 215  ILE E 216  GLY E 258  THR E 259                    
SITE     2 AD5 10 GLY E 260  LEU E 263  MET E 264  VAL E 390                    
SITE     3 AD5 10 ALA E 419  ALA E 422                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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