GenomeNet

Database: PDB
Entry: 6PZA
LinkDB: 6PZA
Original site: 6PZA 
HEADER    MEMBRANE PROTEIN                        31-JUL-19   6PZA              
TITLE     CRYO-EM STRUCTURE OF THE PANCREATIC BETA-CELL SUR1 BOUND TO ATP AND   
TITLE    2 GLIBENCLAMIDE                                                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8;                
COMPND   3 CHAIN: C;                                                            
COMPND   4 SYNONYM: SUR1, SULFONYLUREA RECEPTOR 1;                              
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11;       
COMPND   8 CHAIN: D;                                                            
COMPND   9 SYNONYM: KNTP, BIR,INWARD RECTIFIER K(+) CHANNEL KIR6.2,POTASSIUM    
COMPND  10 CHANNEL,INWARDLY RECTIFYING SUBFAMILY J MEMBER 11;                   
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: CRICETUS CRICETUS;                              
SOURCE   3 ORGANISM_COMMON: BLACK-BELLIED HAMSTER;                              
SOURCE   4 ORGANISM_TAXID: 10034;                                               
SOURCE   5 GENE: ABCC8, SUR;                                                    
SOURCE   6 EXPRESSION_SYSTEM: RATTUS NORVEGICUS;                                
SOURCE   7 EXPRESSION_SYSTEM_COMMON: RAT;                                       
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 10116;                                      
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  11 ORGANISM_COMMON: RAT;                                                
SOURCE  12 ORGANISM_TAXID: 10116;                                               
SOURCE  13 GENE: KCNJ11;                                                        
SOURCE  14 EXPRESSION_SYSTEM: RATTUS NORVEGICUS;                                
SOURCE  15 EXPRESSION_SYSTEM_COMMON: RAT;                                       
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 10116                                       
KEYWDS    KATP, SUR1, GBC, MEMBRANE PROTEIN                                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    S.L.SHYNG,C.YOSHIOKA,G.M.MARTIN,M.W.SUNG                              
REVDAT   3   07-OCT-20 6PZA    1       JRNL                                     
REVDAT   2   25-DEC-19 6PZA    1       REMARK                                   
REVDAT   1   14-AUG-19 6PZA    0                                                
JRNL        AUTH   G.M.MARTIN,M.W.SUNG,Z.YANG,L.M.INNES,B.KANDASAMY,L.L.DAVID,  
JRNL        AUTH 2 C.YOSHIOKA,S.L.SHYNG                                         
JRNL        TITL   MECHANISM OF PHARMACOCHAPERONING IN A MAMMALIAN K ATP        
JRNL        TITL 2 CHANNEL REVEALED BY CRYO-EM.                                 
JRNL        REF    ELIFE                         V.   8       2019              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   31343405                                                     
JRNL        DOI    10.7554/ELIFE.46417                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.74 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : COOT, PHENIX                              
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 6BAA                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.740                          
REMARK   3   NUMBER OF PARTICLES               : 171420                         
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6PZA COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-AUG-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000243338.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : KATP-RPG-ATP; SUR1; KNTP          
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 40.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLU C   622                                                      
REMARK 465     GLN C   623                                                      
REMARK 465     CYS C   624                                                      
REMARK 465     ALA C   625                                                      
REMARK 465     PRO C   626                                                      
REMARK 465     ARG C   627                                                      
REMARK 465     GLU C   628                                                      
REMARK 465     PRO C   629                                                      
REMARK 465     ALA C   630                                                      
REMARK 465     PRO C   631                                                      
REMARK 465     GLN C   632                                                      
REMARK 465     GLY C   633                                                      
REMARK 465     GLN C   634                                                      
REMARK 465     ALA C   635                                                      
REMARK 465     GLY C   636                                                      
REMARK 465     LYS C   637                                                      
REMARK 465     TYR C   638                                                      
REMARK 465     GLN C   639                                                      
REMARK 465     ALA C   640                                                      
REMARK 465     VAL C   641                                                      
REMARK 465     PRO C   642                                                      
REMARK 465     LEU C   643                                                      
REMARK 465     LYS C   644                                                      
REMARK 465     VAL C   645                                                      
REMARK 465     VAL C   646                                                      
REMARK 465     ASN C   647                                                      
REMARK 465     ARG C   648                                                      
REMARK 465     LYS C   649                                                      
REMARK 465     ARG C   650                                                      
REMARK 465     PRO C   651                                                      
REMARK 465     ALA C   652                                                      
REMARK 465     ARG C   653                                                      
REMARK 465     GLU C   654                                                      
REMARK 465     GLU C   655                                                      
REMARK 465     VAL C   656                                                      
REMARK 465     ARG C   657                                                      
REMARK 465     ASP C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     LEU C   660                                                      
REMARK 465     GLY C   661                                                      
REMARK 465     PRO C   662                                                      
REMARK 465     LEU C   663                                                      
REMARK 465     GLN C   664                                                      
REMARK 465     ARG C   665                                                      
REMARK 465     LEU C   666                                                      
REMARK 465     ALA C   667                                                      
REMARK 465     PRO C   668                                                      
REMARK 465     SER C   669                                                      
REMARK 465     MET C   670                                                      
REMARK 465     ASP C   671                                                      
REMARK 465     GLY C   672                                                      
REMARK 465     ASP C   673                                                      
REMARK 465     ALA C   674                                                      
REMARK 465     ASP C   675                                                      
REMARK 465     ASN C   676                                                      
REMARK 465     PHE C   677                                                      
REMARK 465     LEU C   743                                                      
REMARK 465     PRO C   744                                                      
REMARK 465     ASP C   745                                                      
REMARK 465     SER C   746                                                      
REMARK 465     GLU C   747                                                      
REMARK 465     GLY C   748                                                      
REMARK 465     GLU C   749                                                      
REMARK 465     ASP C   750                                                      
REMARK 465     PRO C   751                                                      
REMARK 465     SER C   752                                                      
REMARK 465     SER C   753                                                      
REMARK 465     PRO C   754                                                      
REMARK 465     GLU C   755                                                      
REMARK 465     ARG C   756                                                      
REMARK 465     GLU C   757                                                      
REMARK 465     THR C   758                                                      
REMARK 465     ALA C   759                                                      
REMARK 465     ALA C   760                                                      
REMARK 465     GLY C   761                                                      
REMARK 465     SER C   762                                                      
REMARK 465     ASP C   763                                                      
REMARK 465     ILE C   764                                                      
REMARK 465     LYS C   929                                                      
REMARK 465     THR C   930                                                      
REMARK 465     LEU C   931                                                      
REMARK 465     MET C   932                                                      
REMARK 465     ASN C   933                                                      
REMARK 465     ARG C   934                                                      
REMARK 465     GLN C   935                                                      
REMARK 465     ASP C   936                                                      
REMARK 465     GLN C   937                                                      
REMARK 465     GLU C   938                                                      
REMARK 465     LEU C   939                                                      
REMARK 465     GLU C   940                                                      
REMARK 465     LYS C   941                                                      
REMARK 465     GLU C   942                                                      
REMARK 465     THR C   943                                                      
REMARK 465     VAL C   944                                                      
REMARK 465     MET C   945                                                      
REMARK 465     GLU C   946                                                      
REMARK 465     ARG C   947                                                      
REMARK 465     LYS C   948                                                      
REMARK 465     ALA C   949                                                      
REMARK 465     SER C   950                                                      
REMARK 465     GLU C   951                                                      
REMARK 465     PRO C   952                                                      
REMARK 465     SER C   953                                                      
REMARK 465     GLN C   954                                                      
REMARK 465     GLY C   955                                                      
REMARK 465     LEU C   956                                                      
REMARK 465     PRO C   957                                                      
REMARK 465     ARG C   958                                                      
REMARK 465     ALA C   959                                                      
REMARK 465     MET C   960                                                      
REMARK 465     SER C   961                                                      
REMARK 465     SER C   962                                                      
REMARK 465     ARG C   963                                                      
REMARK 465     ASP C   964                                                      
REMARK 465     GLY C   965                                                      
REMARK 465     LEU C   966                                                      
REMARK 465     LEU C   967                                                      
REMARK 465     LEU C   968                                                      
REMARK 465     ASP C   969                                                      
REMARK 465     GLU C   970                                                      
REMARK 465     GLU C   971                                                      
REMARK 465     GLU C   972                                                      
REMARK 465     GLU C   973                                                      
REMARK 465     GLU C   974                                                      
REMARK 465     GLU C   975                                                      
REMARK 465     GLU C   976                                                      
REMARK 465     ALA C   977                                                      
REMARK 465     ALA C   978                                                      
REMARK 465     GLU C   979                                                      
REMARK 465     SER C   980                                                      
REMARK 465     GLU C   981                                                      
REMARK 465     GLU C   982                                                      
REMARK 465     ASP C   983                                                      
REMARK 465     ASP C   984                                                      
REMARK 465     ASN C   985                                                      
REMARK 465     LEU C   986                                                      
REMARK 465     SER C   987                                                      
REMARK 465     SER C   988                                                      
REMARK 465     VAL C   989                                                      
REMARK 465     LEU C   990                                                      
REMARK 465     HIS C   991                                                      
REMARK 465     SER C  1045                                                      
REMARK 465     PRO C  1046                                                      
REMARK 465     ALA C  1047                                                      
REMARK 465     ALA C  1048                                                      
REMARK 465     ARG C  1049                                                      
REMARK 465     ASN C  1050                                                      
REMARK 465     CYS C  1051                                                      
REMARK 465     SER C  1052                                                      
REMARK 465     LEU C  1053                                                      
REMARK 465     SER C  1054                                                      
REMARK 465     GLN C  1055                                                      
REMARK 465     GLU C  1056                                                      
REMARK 465     CYS C  1057                                                      
REMARK 465     ASP C  1058                                                      
REMARK 465     LEU C  1059                                                      
REMARK 465     ARG C  1579                                                      
REMARK 465     ALA C  1580                                                      
REMARK 465     ASP C  1581                                                      
REMARK 465     LYS C  1582                                                      
REMARK 465     ASP D    20                                                      
REMARK 465     PRO D    21                                                      
REMARK 465     THR D    22                                                      
REMARK 465     GLU D    23                                                      
REMARK 465     PRO D    24                                                      
REMARK 465     ARG D    25                                                      
REMARK 465     TYR D    26                                                      
REMARK 465     ARG D    27                                                      
REMARK 465     THR D    28                                                      
REMARK 465     ARG D    29                                                      
REMARK 465     GLU D    30                                                      
REMARK 465     ARG D    31                                                      
REMARK 465     ARG D    32                                                      
REMARK 465     ALA D    33                                                      
REMARK 465     ARG D    34                                                      
REMARK 465     PHE D    35                                                      
REMARK 465     VAL D    36                                                      
REMARK 465     SER D    37                                                      
REMARK 465     LYS D    38                                                      
REMARK 465     LYS D    39                                                      
REMARK 465     GLY D    40                                                      
REMARK 465     ASN D    41                                                      
REMARK 465     CYS D    42                                                      
REMARK 465     ASN D    43                                                      
REMARK 465     VAL D    44                                                      
REMARK 465     ALA D    45                                                      
REMARK 465     HIS D    46                                                      
REMARK 465     LYS D    47                                                      
REMARK 465     ASN D    48                                                      
REMARK 465     ILE D    49                                                      
REMARK 465     ARG D    50                                                      
REMARK 465     GLU D    51                                                      
REMARK 465     GLN D    52                                                      
REMARK 465     GLY D    53                                                      
REMARK 465     ARG D    54                                                      
REMARK 465     PHE D    55                                                      
REMARK 465     LEU D    56                                                      
REMARK 465     GLN D    57                                                      
REMARK 465     ASP D    58                                                      
REMARK 465     VAL D    59                                                      
REMARK 465     PHE D    60                                                      
REMARK 465     THR D    61                                                      
REMARK 465     THR D    62                                                      
REMARK 465     LEU D    63                                                      
REMARK 465     VAL D    64                                                      
REMARK 465     ASP D    65                                                      
REMARK 465     LEU D    66                                                      
REMARK 465     LYS D    67                                                      
REMARK 465     TRP D    68                                                      
REMARK 465     PRO D    69                                                      
REMARK 465     HIS D    70                                                      
REMARK 465     THR D    71                                                      
REMARK 465     LEU D    72                                                      
REMARK 465     LEU D    73                                                      
REMARK 465     ILE D    74                                                      
REMARK 465     PHE D    75                                                      
REMARK 465     THR D    76                                                      
REMARK 465     MET D    77                                                      
REMARK 465     SER D    78                                                      
REMARK 465     PHE D    79                                                      
REMARK 465     LEU D    80                                                      
REMARK 465     CYS D    81                                                      
REMARK 465     SER D    82                                                      
REMARK 465     TRP D    83                                                      
REMARK 465     LEU D    84                                                      
REMARK 465     LEU D    85                                                      
REMARK 465     PHE D    86                                                      
REMARK 465     ALA D    87                                                      
REMARK 465     MET D    88                                                      
REMARK 465     VAL D    89                                                      
REMARK 465     TRP D    90                                                      
REMARK 465     TRP D    91                                                      
REMARK 465     LEU D    92                                                      
REMARK 465     ILE D    93                                                      
REMARK 465     ALA D    94                                                      
REMARK 465     PHE D    95                                                      
REMARK 465     ALA D    96                                                      
REMARK 465     HIS D    97                                                      
REMARK 465     GLY D    98                                                      
REMARK 465     ASP D    99                                                      
REMARK 465     LEU D   100                                                      
REMARK 465     ALA D   101                                                      
REMARK 465     PRO D   102                                                      
REMARK 465     GLY D   103                                                      
REMARK 465     GLU D   104                                                      
REMARK 465     GLY D   105                                                      
REMARK 465     THR D   106                                                      
REMARK 465     ASN D   107                                                      
REMARK 465     VAL D   108                                                      
REMARK 465     PRO D   109                                                      
REMARK 465     CYS D   110                                                      
REMARK 465     VAL D   111                                                      
REMARK 465     THR D   112                                                      
REMARK 465     SER D   113                                                      
REMARK 465     ILE D   114                                                      
REMARK 465     HIS D   115                                                      
REMARK 465     SER D   116                                                      
REMARK 465     PHE D   117                                                      
REMARK 465     SER D   118                                                      
REMARK 465     SER D   119                                                      
REMARK 465     ALA D   120                                                      
REMARK 465     PHE D   121                                                      
REMARK 465     LEU D   122                                                      
REMARK 465     PHE D   123                                                      
REMARK 465     SER D   124                                                      
REMARK 465     ILE D   125                                                      
REMARK 465     GLU D   126                                                      
REMARK 465     VAL D   127                                                      
REMARK 465     GLN D   128                                                      
REMARK 465     VAL D   129                                                      
REMARK 465     THR D   130                                                      
REMARK 465     ILE D   131                                                      
REMARK 465     GLY D   132                                                      
REMARK 465     PHE D   133                                                      
REMARK 465     GLY D   134                                                      
REMARK 465     GLY D   135                                                      
REMARK 465     ARG D   136                                                      
REMARK 465     MET D   137                                                      
REMARK 465     VAL D   138                                                      
REMARK 465     THR D   139                                                      
REMARK 465     GLU D   140                                                      
REMARK 465     GLU D   141                                                      
REMARK 465     CYS D   142                                                      
REMARK 465     PRO D   143                                                      
REMARK 465     LEU D   144                                                      
REMARK 465     ALA D   145                                                      
REMARK 465     ILE D   146                                                      
REMARK 465     LEU D   147                                                      
REMARK 465     ILE D   148                                                      
REMARK 465     LEU D   149                                                      
REMARK 465     ILE D   150                                                      
REMARK 465     VAL D   151                                                      
REMARK 465     GLN D   152                                                      
REMARK 465     ASN D   153                                                      
REMARK 465     ILE D   154                                                      
REMARK 465     VAL D   155                                                      
REMARK 465     GLY D   156                                                      
REMARK 465     LEU D   157                                                      
REMARK 465     MET D   158                                                      
REMARK 465     ILE D   159                                                      
REMARK 465     ASN D   160                                                      
REMARK 465     ALA D   161                                                      
REMARK 465     ILE D   162                                                      
REMARK 465     MET D   163                                                      
REMARK 465     LEU D   164                                                      
REMARK 465     GLY D   165                                                      
REMARK 465     CYS D   166                                                      
REMARK 465     ILE D   167                                                      
REMARK 465     PHE D   168                                                      
REMARK 465     MET D   169                                                      
REMARK 465     LYS D   170                                                      
REMARK 465     THR D   171                                                      
REMARK 465     ALA D   172                                                      
REMARK 465     GLN D   173                                                      
REMARK 465     ALA D   174                                                      
REMARK 465     HIS D   175                                                      
REMARK 465     ARG D   176                                                      
REMARK 465     ARG D   177                                                      
REMARK 465     ALA D   178                                                      
REMARK 465     GLU D   179                                                      
REMARK 465     THR D   180                                                      
REMARK 465     LEU D   181                                                      
REMARK 465     ILE D   182                                                      
REMARK 465     PHE D   183                                                      
REMARK 465     SER D   184                                                      
REMARK 465     LYS D   185                                                      
REMARK 465     HIS D   186                                                      
REMARK 465     ALA D   187                                                      
REMARK 465     VAL D   188                                                      
REMARK 465     ILE D   189                                                      
REMARK 465     THR D   190                                                      
REMARK 465     PRO D   191                                                      
REMARK 465     ARG D   192                                                      
REMARK 465     HIS D   193                                                      
REMARK 465     GLY D   194                                                      
REMARK 465     ARG D   195                                                      
REMARK 465     LEU D   196                                                      
REMARK 465     CYS D   197                                                      
REMARK 465     PHE D   198                                                      
REMARK 465     MET D   199                                                      
REMARK 465     LEU D   200                                                      
REMARK 465     ARG D   201                                                      
REMARK 465     VAL D   202                                                      
REMARK 465     GLY D   203                                                      
REMARK 465     ASP D   204                                                      
REMARK 465     LEU D   205                                                      
REMARK 465     ARG D   206                                                      
REMARK 465     LYS D   207                                                      
REMARK 465     SER D   208                                                      
REMARK 465     MET D   209                                                      
REMARK 465     ILE D   210                                                      
REMARK 465     ILE D   211                                                      
REMARK 465     SER D   212                                                      
REMARK 465     ALA D   213                                                      
REMARK 465     THR D   214                                                      
REMARK 465     ILE D   215                                                      
REMARK 465     HIS D   216                                                      
REMARK 465     MET D   217                                                      
REMARK 465     GLN D   218                                                      
REMARK 465     VAL D   219                                                      
REMARK 465     VAL D   220                                                      
REMARK 465     ARG D   221                                                      
REMARK 465     LYS D   222                                                      
REMARK 465     THR D   223                                                      
REMARK 465     THR D   224                                                      
REMARK 465     SER D   225                                                      
REMARK 465     PRO D   226                                                      
REMARK 465     GLU D   227                                                      
REMARK 465     GLY D   228                                                      
REMARK 465     GLU D   229                                                      
REMARK 465     VAL D   230                                                      
REMARK 465     VAL D   231                                                      
REMARK 465     PRO D   232                                                      
REMARK 465     LEU D   233                                                      
REMARK 465     HIS D   234                                                      
REMARK 465     GLN D   235                                                      
REMARK 465     VAL D   236                                                      
REMARK 465     ASP D   237                                                      
REMARK 465     ILE D   238                                                      
REMARK 465     PRO D   239                                                      
REMARK 465     MET D   240                                                      
REMARK 465     GLU D   241                                                      
REMARK 465     ASN D   242                                                      
REMARK 465     GLY D   243                                                      
REMARK 465     VAL D   244                                                      
REMARK 465     GLY D   245                                                      
REMARK 465     GLY D   246                                                      
REMARK 465     ASN D   247                                                      
REMARK 465     SER D   248                                                      
REMARK 465     ILE D   249                                                      
REMARK 465     PHE D   250                                                      
REMARK 465     LEU D   251                                                      
REMARK 465     VAL D   252                                                      
REMARK 465     ALA D   253                                                      
REMARK 465     PRO D   254                                                      
REMARK 465     LEU D   255                                                      
REMARK 465     ILE D   256                                                      
REMARK 465     ILE D   257                                                      
REMARK 465     TYR D   258                                                      
REMARK 465     HIS D   259                                                      
REMARK 465     VAL D   260                                                      
REMARK 465     ILE D   261                                                      
REMARK 465     ASP D   262                                                      
REMARK 465     SER D   263                                                      
REMARK 465     ASN D   264                                                      
REMARK 465     SER D   265                                                      
REMARK 465     PRO D   266                                                      
REMARK 465     LEU D   267                                                      
REMARK 465     TYR D   268                                                      
REMARK 465     ASP D   269                                                      
REMARK 465     LEU D   270                                                      
REMARK 465     ALA D   271                                                      
REMARK 465     PRO D   272                                                      
REMARK 465     SER D   273                                                      
REMARK 465     ASP D   274                                                      
REMARK 465     LEU D   275                                                      
REMARK 465     HIS D   276                                                      
REMARK 465     HIS D   277                                                      
REMARK 465     HIS D   278                                                      
REMARK 465     GLN D   279                                                      
REMARK 465     ASP D   280                                                      
REMARK 465     LEU D   281                                                      
REMARK 465     GLU D   282                                                      
REMARK 465     ILE D   283                                                      
REMARK 465     ILE D   284                                                      
REMARK 465     VAL D   285                                                      
REMARK 465     ILE D   286                                                      
REMARK 465     LEU D   287                                                      
REMARK 465     GLU D   288                                                      
REMARK 465     GLY D   289                                                      
REMARK 465     VAL D   290                                                      
REMARK 465     VAL D   291                                                      
REMARK 465     GLU D   292                                                      
REMARK 465     THR D   293                                                      
REMARK 465     THR D   294                                                      
REMARK 465     GLY D   295                                                      
REMARK 465     ILE D   296                                                      
REMARK 465     THR D   297                                                      
REMARK 465     THR D   298                                                      
REMARK 465     GLN D   299                                                      
REMARK 465     ALA D   300                                                      
REMARK 465     ARG D   301                                                      
REMARK 465     THR D   302                                                      
REMARK 465     SER D   303                                                      
REMARK 465     TYR D   304                                                      
REMARK 465     LEU D   305                                                      
REMARK 465     ALA D   306                                                      
REMARK 465     ASP D   307                                                      
REMARK 465     GLU D   308                                                      
REMARK 465     ILE D   309                                                      
REMARK 465     LEU D   310                                                      
REMARK 465     TRP D   311                                                      
REMARK 465     GLY D   312                                                      
REMARK 465     GLN D   313                                                      
REMARK 465     ARG D   314                                                      
REMARK 465     PHE D   315                                                      
REMARK 465     VAL D   316                                                      
REMARK 465     PRO D   317                                                      
REMARK 465     ILE D   318                                                      
REMARK 465     VAL D   319                                                      
REMARK 465     ALA D   320                                                      
REMARK 465     GLU D   321                                                      
REMARK 465     GLU D   322                                                      
REMARK 465     ASP D   323                                                      
REMARK 465     GLY D   324                                                      
REMARK 465     ARG D   325                                                      
REMARK 465     TYR D   326                                                      
REMARK 465     SER D   327                                                      
REMARK 465     VAL D   328                                                      
REMARK 465     ASP D   329                                                      
REMARK 465     TYR D   330                                                      
REMARK 465     SER D   331                                                      
REMARK 465     LYS D   332                                                      
REMARK 465     PHE D   333                                                      
REMARK 465     GLY D   334                                                      
REMARK 465     ASN D   335                                                      
REMARK 465     THR D   336                                                      
REMARK 465     VAL D   337                                                      
REMARK 465     LYS D   338                                                      
REMARK 465     VAL D   339                                                      
REMARK 465     PRO D   340                                                      
REMARK 465     THR D   341                                                      
REMARK 465     PRO D   342                                                      
REMARK 465     LEU D   343                                                      
REMARK 465     CYS D   344                                                      
REMARK 465     THR D   345                                                      
REMARK 465     ALA D   346                                                      
REMARK 465     ARG D   347                                                      
REMARK 465     GLN D   348                                                      
REMARK 465     LEU D   349                                                      
REMARK 465     ASP D   350                                                      
REMARK 465     GLU D   351                                                      
REMARK 465     ASP D   352                                                      
REMARK 465     ARG D   353                                                      
REMARK 465     SER D   354                                                      
REMARK 465     LEU D   355                                                      
REMARK 465     LEU D   356                                                      
REMARK 465     ASP D   357                                                      
REMARK 465     ALA D   358                                                      
REMARK 465     LEU D   359                                                      
REMARK 465     THR D   360                                                      
REMARK 465     LEU D   361                                                      
REMARK 465     ALA D   362                                                      
REMARK 465     SER D   363                                                      
REMARK 465     SER D   364                                                      
REMARK 465     ARG D   365                                                      
REMARK 465     GLY D   366                                                      
REMARK 465     PRO D   367                                                      
REMARK 465     LEU D   368                                                      
REMARK 465     ARG D   369                                                      
REMARK 465     LYS D   370                                                      
REMARK 465     ARG D   371                                                      
REMARK 465     SER D   372                                                      
REMARK 465     VAL D   373                                                      
REMARK 465     ALA D   374                                                      
REMARK 465     VAL D   375                                                      
REMARK 465     ALA D   376                                                      
REMARK 465     LYS D   377                                                      
REMARK 465     ALA D   378                                                      
REMARK 465     LYS D   379                                                      
REMARK 465     PRO D   380                                                      
REMARK 465     LYS D   381                                                      
REMARK 465     PHE D   382                                                      
REMARK 465     SER D   383                                                      
REMARK 465     ILE D   384                                                      
REMARK 465     SER D   385                                                      
REMARK 465     PRO D   386                                                      
REMARK 465     ASP D   387                                                      
REMARK 465     SER D   388                                                      
REMARK 465     LEU D   389                                                      
REMARK 465     SER D   390                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     THR C   8    OG1  CG2                                            
REMARK 470     GLU C   9    CG   CD   OE1  OE2                                  
REMARK 470     SER C  12    OG                                                  
REMARK 470     VAL C  17    CG1  CG2                                            
REMARK 470     ASP C  18    CG   OD1  OD2                                       
REMARK 470     VAL C  21    CG1  CG2                                            
REMARK 470     LEU C  22    CG   CD1  CD2                                       
REMARK 470     ASN C  23    CG   OD1  ND2                                       
REMARK 470     ASN C  24    CG   OD1  ND2                                       
REMARK 470     LYS C  57    CG   CD   CE   NZ                                   
REMARK 470     VAL C  58    CG1  CG2                                            
REMARK 470     HIS C  59    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE C  60    CG1  CG2  CD1                                       
REMARK 470     HIS C  61    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS C  62    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER C  63    OG                                                  
REMARK 470     THR C  64    OG1  CG2                                            
REMARK 470     ASP C  96    CG   OD1  OD2                                       
REMARK 470     VAL C  98    CG1  CG2                                            
REMARK 470     THR C  99    OG1  CG2                                            
REMARK 470     GLU C 100    CG   CD   OE1  OE2                                  
REMARK 470     SER C 101    OG                                                  
REMARK 470     ARG C 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 128    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 166    CG   CD   OE1  NE2                                  
REMARK 470     ARG C 194    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C 196    CG1  CG2  CD1                                       
REMARK 470     LYS C 199    CG   CD   CE   NZ                                   
REMARK 470     THR C 200    OG1  CG2                                            
REMARK 470     ARG C 202    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 203    CG   CD   OE1  OE2                                  
REMARK 470     VAL C 204    CG1  CG2                                            
REMARK 470     LYS C 205    CG   CD   CE   NZ                                   
REMARK 470     GLU C 208    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 209    CG   OD1  OD2                                       
REMARK 470     LEU C 210    CG   CD1  CD2                                       
REMARK 470     GLN C 211    CG   CD   OE1  NE2                                  
REMARK 470     ASP C 212    CG   OD1  OD2                                       
REMARK 470     LEU C 213    CG   CD1  CD2                                       
REMARK 470     SER C 226    OG                                                  
REMARK 470     ILE C 237    CG1  CG2  CD1                                       
REMARK 470     LYS C 238    CG   CD   CE   NZ                                   
REMARK 470     LYS C 242    CG   CD   CE   NZ                                   
REMARK 470     LYS C 243    CG   CD   CE   NZ                                   
REMARK 470     ASP C 246    CG   OD1  OD2                                       
REMARK 470     LEU C 247    CG   CD1  CD2                                       
REMARK 470     ARG C 248    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C 250    CG1  CG2  CD1                                       
REMARK 470     ASP C 271    CG   OD1  OD2                                       
REMARK 470     ARG C 275    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 276    CG   CD   CE   NZ                                   
REMARK 470     ASP C 277    CG   OD1  OD2                                       
REMARK 470     THR C 278    OG1  CG2                                            
REMARK 470     GLN C 279    CG   CD   OE1  NE2                                  
REMARK 470     SER C 280    OG                                                  
REMARK 470     GLN C 282    CG   CD   OE1  NE2                                  
REMARK 470     ASP C 310    CG   OD1  OD2                                       
REMARK 470     ASP C 325    CG   OD1  OD2                                       
REMARK 470     LYS C 329    CG   CD   CE   NZ                                   
REMARK 470     GLU C 330    CG   CD   OE1  OE2                                  
REMARK 470     ASN C 331    CG   OD1  ND2                                       
REMARK 470     HIS C 332    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL C 333    CG1  CG2                                            
REMARK 470     PHE C 334    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN C 339    CG   CD   OE1  NE2                                  
REMARK 470     LEU C 341    CG   CD1  CD2                                       
REMARK 470     VAL C 346    CG1  CG2                                            
REMARK 470     GLU C 350    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 352    CG   CD1  CD2                                       
REMARK 470     ASN C 354    CG   OD1  ND2                                       
REMARK 470     MET C 402    CG   SD   CE                                        
REMARK 470     ASN C 406    CG   OD1  ND2                                       
REMARK 470     GLU C 411    CG   CD   OE1  OE2                                  
REMARK 470     ASN C 419    CG   OD1  ND2                                       
REMARK 470     MET C 441    CG   SD   CE                                        
REMARK 470     SER C 459    OG                                                  
REMARK 470     ILE C 462    CG1  CG2  CD1                                       
REMARK 470     ILE C 468    CG1  CG2  CD1                                       
REMARK 470     LEU C 469    CG   CD1  CD2                                       
REMARK 470     LEU C 470    CG   CD1  CD2                                       
REMARK 470     GLN C 474    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 480    CG   CD   CE   NZ                                   
REMARK 470     GLU C 494    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 496    CG   CD1  CD2                                       
REMARK 470     LYS C 497    CG   CD   CE   NZ                                   
REMARK 470     THR C 499    OG1  CG2                                            
REMARK 470     ASN C 500    CG   OD1  ND2                                       
REMARK 470     GLU C 501    CG   CD   OE1  OE2                                  
REMARK 470     MET C 502    CG   SD   CE                                        
REMARK 470     LEU C 503    CG   CD1  CD2                                       
REMARK 470     MET C 506    CG   SD   CE                                        
REMARK 470     LYS C 507    CG   CD   CE   NZ                                   
REMARK 470     LEU C 508    CG   CD1  CD2                                       
REMARK 470     LEU C 509    CG   CD1  CD2                                       
REMARK 470     LYS C 510    CG   CD   CE   NZ                                   
REMARK 470     LEU C 511    CG   CD1  CD2                                       
REMARK 470     TYR C 512    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU C 515    CG   CD   OE1  OE2                                  
REMARK 470     SER C 516    OG                                                  
REMARK 470     ILE C 517    CG1  CG2  CD1                                       
REMARK 470     CYS C 519    SG                                                  
REMARK 470     SER C 520    OG                                                  
REMARK 470     ARG C 521    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 523    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 527    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 529    CG   CD   OE1  OE2                                  
REMARK 470     SER C 532    OG                                                  
REMARK 470     LEU C 533    CG   CD1  CD2                                       
REMARK 470     ARG C 534    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C 550    CG1  CG2  CD1                                       
REMARK 470     LEU C 556    CG   CD1  CD2                                       
REMARK 470     ILE C 557    CG1  CG2  CD1                                       
REMARK 470     VAL C 560    CG1  CG2                                            
REMARK 470     SER C 564    OG                                                  
REMARK 470     PHE C 566    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C 568    CG   CD   OE1  OE2                                  
REMARK 470     SER C 569    OG                                                  
REMARK 470     SER C 572    OG                                                  
REMARK 470     GLU C 618    CG   CD   OE1  OE2                                  
REMARK 470     ILE C 619    CG1  CG2  CD1                                       
REMARK 470     ARG C 620    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 621    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 678    SG                                                  
REMARK 470     VAL C 679    CG1  CG2                                            
REMARK 470     GLN C 680    CG   CD   OE1  NE2                                  
REMARK 470     ILE C 681    CG1  CG2  CD1                                       
REMARK 470     PHE C 685    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE C 686    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR C 687    OG1  CG2                                            
REMARK 470     THR C 689    OG1  CG2                                            
REMARK 470     ASP C 691    CG   OD1  OD2                                       
REMARK 470     ILE C 693    CG1  CG2  CD1                                       
REMARK 470     THR C 695    OG1  CG2                                            
REMARK 470     LEU C 696    CG   CD1  CD2                                       
REMARK 470     ASN C 698    CG   OD1  ND2                                       
REMARK 470     ILE C 699    CG1  CG2  CD1                                       
REMARK 470     THR C 700    OG1  CG2                                            
REMARK 470     ILE C 701    CG1  CG2  CD1                                       
REMARK 470     ILE C 703    CG1  CG2  CD1                                       
REMARK 470     ARG C 705    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C 708    CG   CD1  CD2                                       
REMARK 470     MET C 710    CG   SD   CE                                        
REMARK 470     ILE C 711    CG1  CG2  CD1                                       
REMARK 470     VAL C 712    CG1  CG2                                            
REMARK 470     GLN C 714    CG   CD   OE1  NE2                                  
REMARK 470     VAL C 715    CG1  CG2                                            
REMARK 470     CYS C 717    SG                                                  
REMARK 470     LYS C 719    CG   CD   CE   NZ                                   
REMARK 470     SER C 720    OG                                                  
REMARK 470     SER C 721    OG                                                  
REMARK 470     LEU C 722    CG   CD1  CD2                                       
REMARK 470     LEU C 723    CG   CD1  CD2                                       
REMARK 470     LEU C 724    CG   CD1  CD2                                       
REMARK 470     THR C 726    OG1  CG2                                            
REMARK 470     LEU C 727    CG   CD1  CD2                                       
REMARK 470     GLU C 729    CG   CD   OE1  OE2                                  
REMARK 470     MET C 730    CG   SD   CE                                        
REMARK 470     GLN C 731    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 732    CG   CD   CE   NZ                                   
REMARK 470     VAL C 733    CG1  CG2                                            
REMARK 470     SER C 734    OG                                                  
REMARK 470     VAL C 737    CG1  CG2                                            
REMARK 470     SER C 741    OG                                                  
REMARK 470     ASN C 742    CG   OD1  ND2                                       
REMARK 470     ARG C 765    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C 766    OG                                                  
REMARK 470     SER C 774    OG                                                  
REMARK 470     LYS C 776    CG   CD   CE   NZ                                   
REMARK 470     LEU C 779    CG   CD1  CD2                                       
REMARK 470     LEU C 780    CG   CD1  CD2                                       
REMARK 470     ASN C 781    CG   OD1  ND2                                       
REMARK 470     THR C 783    OG1  CG2                                            
REMARK 470     VAL C 784    CG1  CG2                                            
REMARK 470     GLU C 785    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 786    CG   CD   OE1  OE2                                  
REMARK 470     ASN C 787    CG   OD1  ND2                                       
REMARK 470     ILE C 788    CG1  CG2  CD1                                       
REMARK 470     THR C 789    OG1  CG2                                            
REMARK 470     GLU C 791    CG   CD   OE1  OE2                                  
REMARK 470     ASN C 795    CG   OD1  ND2                                       
REMARK 470     LYS C 796    CG   CD   CE   NZ                                   
REMARK 470     GLN C 797    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 800    CG   CD   CE   NZ                                   
REMARK 470     MET C 801    CG   SD   CE                                        
REMARK 470     VAL C 802    CG1  CG2                                            
REMARK 470     ILE C 803    CG1  CG2  CD1                                       
REMARK 470     GLU C 804    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 806    SG                                                  
REMARK 470     SER C 807    OG                                                  
REMARK 470     LEU C 808    CG   CD1  CD2                                       
REMARK 470     GLN C 809    CG   CD   OE1  NE2                                  
REMARK 470     ASP C 811    CG   OD1  OD2                                       
REMARK 470     ILE C 812    CG1  CG2  CD1                                       
REMARK 470     ASP C 813    CG   OD1  OD2                                       
REMARK 470     ILE C 814    CG1  CG2  CD1                                       
REMARK 470     LEU C 815    CG   CD1  CD2                                       
REMARK 470     ASP C 819    CG   OD1  OD2                                       
REMARK 470     GLN C 820    CG   CD   OE1  NE2                                  
REMARK 470     THR C 821    OG1  CG2                                            
REMARK 470     GLN C 822    CG   CD   OE1  NE2                                  
REMARK 470     ILE C 823    CG1  CG2  CD1                                       
REMARK 470     ILE C 828    CG1  CG2  CD1                                       
REMARK 470     ASN C 829    CG   OD1  ND2                                       
REMARK 470     LEU C 830    CG   CD1  CD2                                       
REMARK 470     SER C 831    OG                                                  
REMARK 470     GLN C 836    CG   CD   OE1  NE2                                  
REMARK 470     ILE C 838    CG1  CG2  CD1                                       
REMARK 470     SER C 839    OG                                                  
REMARK 470     VAL C 840    CG1  CG2                                            
REMARK 470     LEU C 844    CG   CD1  CD2                                       
REMARK 470     GLN C 846    CG   CD   OE1  NE2                                  
REMARK 470     THR C 848    OG1  CG2                                            
REMARK 470     ASN C 849    CG   OD1  ND2                                       
REMARK 470     VAL C 850    CG1  CG2                                            
REMARK 470     VAL C 851    CG1  CG2                                            
REMARK 470     LEU C 853    CG   CD1  CD2                                       
REMARK 470     ASP C 854    CG   OD1  OD2                                       
REMARK 470     ASP C 855    CG   OD1  OD2                                       
REMARK 470     PHE C 857    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER C 858    OG                                                  
REMARK 470     LEU C 860    CG   CD1  CD2                                       
REMARK 470     ASP C 861    CG   OD1  OD2                                       
REMARK 470     VAL C 862    CG1  CG2                                            
REMARK 470     LEU C 864    CG   CD1  CD2                                       
REMARK 470     ASP C 866    CG   OD1  OD2                                       
REMARK 470     LEU C 868    CG   CD1  CD2                                       
REMARK 470     MET C 869    CG   SD   CE                                        
REMARK 470     GLN C 870    CG   CD   OE1  NE2                                  
REMARK 470     ILE C 873    CG1  CG2  CD1                                       
REMARK 470     GLU C 875    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 876    CG   CD1  CD2                                       
REMARK 470     LEU C 877    CG   CD1  CD2                                       
REMARK 470     ARG C 878    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C 879    CG   OD1  OD2                                       
REMARK 470     ASP C 880    CG   OD1  OD2                                       
REMARK 470     LYS C 881    CG   CD   CE   NZ                                   
REMARK 470     ARG C 882    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C 883    OG1  CG2                                            
REMARK 470     VAL C 884    CG1  CG2                                            
REMARK 470     VAL C 885    CG1  CG2                                            
REMARK 470     LEU C 886    CG   CD1  CD2                                       
REMARK 470     VAL C 887    CG1  CG2                                            
REMARK 470     LEU C 891    CG   CD1  CD2                                       
REMARK 470     LEU C 894    CG   CD1  CD2                                       
REMARK 470     ASP C 898    CG   OD1  OD2                                       
REMARK 470     ILE C 900    CG1  CG2  CD1                                       
REMARK 470     ILE C 901    CG1  CG2  CD1                                       
REMARK 470     MET C 903    CG   SD   CE                                        
REMARK 470     LYS C 904    CG   CD   CE   NZ                                   
REMARK 470     ASP C 905    CG   OD1  OD2                                       
REMARK 470     THR C 907    OG1  CG2                                            
REMARK 470     ILE C 908    CG1  CG2  CD1                                       
REMARK 470     GLN C 909    CG   CD   OE1  NE2                                  
REMARK 470     ARG C 910    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 911    CG   CD   OE1  OE2                                  
REMARK 470     THR C 913    OG1  CG2                                            
REMARK 470     LEU C 914    CG   CD1  CD2                                       
REMARK 470     LYS C 915    CG   CD   CE   NZ                                   
REMARK 470     ASP C 916    CG   OD1  OD2                                       
REMARK 470     PHE C 917    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN C 918    CG   CD   OE1  NE2                                  
REMARK 470     ARG C 919    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C 920    OG                                                  
REMARK 470     GLU C 921    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 922    SG                                                  
REMARK 470     GLN C 923    CG   CD   OE1  NE2                                  
REMARK 470     LEU C 924    CG   CD1  CD2                                       
REMARK 470     PHE C 925    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C 926    CG   CD   OE1  OE2                                  
REMARK 470     HIS C 927    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TRP C 928    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 928    CZ3  CH2                                            
REMARK 470     GLN C 992    CG   CD   OE1  NE2                                  
REMARK 470     ARG C 993    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C 996    CG1  CG2  CD1                                       
REMARK 470     TRP C 998    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 998    CZ3  CH2                                            
REMARK 470     ARG C 999    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS C1001    SG                                                  
REMARK 470     THR C1002    OG1  CG2                                            
REMARK 470     TYR C1004    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU C1005    CG   CD1  CD2                                       
REMARK 470     SER C1006    OG                                                  
REMARK 470     SER C1007    OG                                                  
REMARK 470     LEU C1011    CG   CD1  CD2                                       
REMARK 470     LEU C1012    CG   CD1  CD2                                       
REMARK 470     LEU C1013    CG   CD1  CD2                                       
REMARK 470     LEU C1015    CG   CD1  CD2                                       
REMARK 470     LEU C1016    CG   CD1  CD2                                       
REMARK 470     VAL C1017    CG1  CG2                                            
REMARK 470     SER C1019    OG                                                  
REMARK 470     GLN C1020    CG   CD   OE1  NE2                                  
REMARK 470     LEU C1021    CG   CD1  CD2                                       
REMARK 470     LEU C1022    CG   CD1  CD2                                       
REMARK 470     LYS C1023    CG   CD   CE   NZ                                   
REMARK 470     ASP C1031    CG   OD1  OD2                                       
REMARK 470     LEU C1034    CG   CD1  CD2                                       
REMARK 470     LYS C1036    CG   CD   CE   NZ                                   
REMARK 470     ASP C1039    CG   OD1  OD2                                       
REMARK 470     SER C1040    OG                                                  
REMARK 470     LEU C1042    CG   CD1  CD2                                       
REMARK 470     VAL C1043    CG1  CG2                                            
REMARK 470     LEU C1044    CG   CD1  CD2                                       
REMARK 470     ASP C1060    CG   OD1  OD2                                       
REMARK 470     THR C1069    OG1  CG2                                            
REMARK 470     LEU C1071    CG   CD1  CD2                                       
REMARK 470     CYS C1072    SG                                                  
REMARK 470     SER C1073    OG                                                  
REMARK 470     ILE C1076    CG1  CG2  CD1                                       
REMARK 470     VAL C1077    CG1  CG2                                            
REMARK 470     LEU C1078    CG   CD1  CD2                                       
REMARK 470     LEU C1080    CG   CD1  CD2                                       
REMARK 470     VAL C1081    CG1  CG2                                            
REMARK 470     THR C1082    OG1  CG2                                            
REMARK 470     SER C1083    OG                                                  
REMARK 470     VAL C1084    CG1  CG2                                            
REMARK 470     THR C1085    OG1  CG2                                            
REMARK 470     VAL C1086    CG1  CG2                                            
REMARK 470     GLU C1087    CG   CD   OE1  OE2                                  
REMARK 470     THR C1089    OG1  CG2                                            
REMARK 470     LYS C1092    CG   CD   CE   NZ                                   
REMARK 470     VAL C1093    CG1  CG2                                            
REMARK 470     LYS C1095    CG   CD   CE   NZ                                   
REMARK 470     SER C1100    OG                                                  
REMARK 470     LEU C1101    CG   CD1  CD2                                       
REMARK 470     LEU C1102    CG   CD1  CD2                                       
REMARK 470     ILE C1105    CG1  CG2  CD1                                       
REMARK 470     ILE C1106    CG1  CG2  CD1                                       
REMARK 470     LEU C1107    CG   CD1  CD2                                       
REMARK 470     MET C1110    CG   SD   CE                                        
REMARK 470     ARG C1111    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C1114    CG   CD   OE1  OE2                                  
REMARK 470     THR C1115    OG1  CG2                                            
REMARK 470     THR C1116    OG1  CG2                                            
REMARK 470     LEU C1118    CG   CD1  CD2                                       
REMARK 470     ILE C1121    CG1  CG2  CD1                                       
REMARK 470     LEU C1122    CG   CD1  CD2                                       
REMARK 470     ARG C1124    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C1131    OG1  CG2                                            
REMARK 470     ILE C1132    CG1  CG2  CD1                                       
REMARK 470     ASP C1133    CG   OD1  OD2                                       
REMARK 470     GLN C1134    CG   CD   OE1  NE2                                  
REMARK 470     GLU C1141    CG   CD   OE1  OE2                                  
REMARK 470     SER C1144    OG                                                  
REMARK 470     LYS C1180    CG   CD   CE   NZ                                   
REMARK 470     GLU C1206    CG   CD   OE1  OE2                                  
REMARK 470     GLU C1220    CG   CD   OE1  OE2                                  
REMARK 470     ARG C1222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET C1252    CG   SD   CE                                        
REMARK 470     ASN C1270    CG   OD1  ND2                                       
REMARK 470     GLU C1275    CG   CD   OE1  OE2                                  
REMARK 470     LEU C1280    CG   CD1  CD2                                       
REMARK 470     LEU C1285    CG   CD1  CD2                                       
REMARK 470     MET C1290    CG   SD   CE                                        
REMARK 470     LEU C1309    CG   CD1  CD2                                       
REMARK 470     LYS C1320    CG   CD   CE   NZ                                   
REMARK 470     GLU C1322    CG   CD   OE1  OE2                                  
REMARK 470     GLU C1324    CG   CD   OE1  OE2                                  
REMARK 470     GLU C1327    CG   CD   OE1  OE2                                  
REMARK 470     LEU C1329    CG   CD1  CD2                                       
REMARK 470     LEU C1330    CG   CD1  CD2                                       
REMARK 470     SER C1333    OG                                                  
REMARK 470     LEU C1334    CG   CD1  CD2                                       
REMARK 470     ILE C1335    CG1  CG2  CD1                                       
REMARK 470     LYS C1337    CG   CD   CE   NZ                                   
REMARK 470     ASN C1338    CG   OD1  ND2                                       
REMARK 470     TRP C1339    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C1339    CZ3  CH2                                            
REMARK 470     ASP C1341    CG   OD1  OD2                                       
REMARK 470     LYS C1344    CG   CD   CE   NZ                                   
REMARK 470     ILE C1345    CG1  CG2  CD1                                       
REMARK 470     GLN C1346    CG   CD   OE1  NE2                                  
REMARK 470     GLN C1348    CG   CD   OE1  NE2                                  
REMARK 470     ASN C1349    CG   OD1  ND2                                       
REMARK 470     LEU C1350    CG   CD1  CD2                                       
REMARK 470     ARG C1353    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C1355    CG   OD1  OD2                                       
REMARK 470     SER C1356    OG                                                  
REMARK 470     SER C1357    OG                                                  
REMARK 470     LEU C1358    CG   CD1  CD2                                       
REMARK 470     LYS C1359    CG   CD   CE   NZ                                   
REMARK 470     ASN C1366    CG   OD1  ND2                                       
REMARK 470     THR C1367    OG1  CG2                                            
REMARK 470     LEU C1368    CG   CD1  CD2                                       
REMARK 470     ILE C1369    CG1  CG2  CD1                                       
REMARK 470     SER C1370    OG                                                  
REMARK 470     GLN C1373    CG   CD   OE1  NE2                                  
REMARK 470     LYS C1374    CG   CD   CE   NZ                                   
REMARK 470     ILE C1375    CG1  CG2  CD1                                       
REMARK 470     ILE C1377    CG1  CG2  CD1                                       
REMARK 470     CYS C1378    SG                                                  
REMARK 470     ARG C1380    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C1381    OG1  CG2                                            
REMARK 470     SER C1383    OG                                                  
REMARK 470     LYS C1385    CG   CD   CE   NZ                                   
REMARK 470     SER C1386    OG                                                  
REMARK 470     SER C1387    OG                                                  
REMARK 470     SER C1389    OG                                                  
REMARK 470     LEU C1390    CG   CD1  CD2                                       
REMARK 470     ARG C1394    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET C1395    CG   SD   CE                                        
REMARK 470     VAL C1396    CG1  CG2                                            
REMARK 470     ASP C1397    CG   OD1  OD2                                       
REMARK 470     MET C1398    CG   SD   CE                                        
REMARK 470     PHE C1399    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C1400    CG   CD   OE1  OE2                                  
REMARK 470     ARG C1402    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C1403    CG1  CG2  CD1                                       
REMARK 470     ILE C1404    CG1  CG2  CD1                                       
REMARK 470     ILE C1405    CG1  CG2  CD1                                       
REMARK 470     ASP C1406    CG   OD1  OD2                                       
REMARK 470     ILE C1408    CG1  CG2  CD1                                       
REMARK 470     ASP C1409    CG   OD1  OD2                                       
REMARK 470     ILE C1410    CG1  CG2  CD1                                       
REMARK 470     LYS C1412    CG   CD   CE   NZ                                   
REMARK 470     LEU C1413    CG   CD1  CD2                                       
REMARK 470     LEU C1415    CG   CD1  CD2                                       
REMARK 470     HIS C1416    CG   ND1  CD2  CE1  NE2                             
REMARK 470     THR C1417    OG1  CG2                                            
REMARK 470     LEU C1418    CG   CD1  CD2                                       
REMARK 470     ARG C1419    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C1420    OG                                                  
REMARK 470     ARG C1421    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C1422    CG   CD1  CD2                                       
REMARK 470     SER C1423    OG                                                  
REMARK 470     ILE C1424    CG1  CG2  CD1                                       
REMARK 470     ILE C1425    CG1  CG2  CD1                                       
REMARK 470     LEU C1426    CG   CD1  CD2                                       
REMARK 470     GLN C1427    CG   CD   OE1  NE2                                  
REMARK 470     ASP C1428    CG   OD1  OD2                                       
REMARK 470     VAL C1430    CG1  CG2                                            
REMARK 470     LEU C1431    CG   CD1  CD2                                       
REMARK 470     PHE C1432    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER C1433    OG                                                  
REMARK 470     THR C1435    OG1  CG2                                            
REMARK 470     ILE C1436    CG1  CG2  CD1                                       
REMARK 470     ARG C1437    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C1438    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN C1439    CG   OD1  ND2                                       
REMARK 470     LEU C1440    CG   CD1  CD2                                       
REMARK 470     ASP C1441    CG   OD1  OD2                                       
REMARK 470     GLU C1443    CG   CD   OE1  OE2                                  
REMARK 470     LYS C1444    CG   CD   CE   NZ                                   
REMARK 470     LYS C1445    CG   CD   CE   NZ                                   
REMARK 470     CYS C1446    SG                                                  
REMARK 470     SER C1447    OG                                                  
REMARK 470     ASP C1448    CG   OD1  OD2                                       
REMARK 470     SER C1449    OG                                                  
REMARK 470     THR C1450    OG1  CG2                                            
REMARK 470     LEU C1451    CG   CD1  CD2                                       
REMARK 470     GLU C1453    CG   CD   OE1  OE2                                  
REMARK 470     LEU C1455    CG   CD1  CD2                                       
REMARK 470     GLU C1456    CG   CD   OE1  OE2                                  
REMARK 470     ILE C1457    CG1  CG2  CD1                                       
REMARK 470     GLN C1459    CG   CD   OE1  NE2                                  
REMARK 470     LYS C1461    CG   CD   CE   NZ                                   
REMARK 470     LEU C1462    CG   CD1  CD2                                       
REMARK 470     VAL C1464    CG1  CG2                                            
REMARK 470     LYS C1465    CG   CD   CE   NZ                                   
REMARK 470     LEU C1467    CG   CD1  CD2                                       
REMARK 470     LEU C1471    CG   CD1  CD2                                       
REMARK 470     ASP C1472    CG   OD1  OD2                                       
REMARK 470     ILE C1474    CG1  CG2  CD1                                       
REMARK 470     ILE C1475    CG1  CG2  CD1                                       
REMARK 470     THR C1476    OG1  CG2                                            
REMARK 470     GLU C1477    CG   CD   OE1  OE2                                  
REMARK 470     GLU C1480    CG   CD   OE1  OE2                                  
REMARK 470     ASN C1481    CG   OD1  ND2                                       
REMARK 470     PHE C1482    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN C1484    CG   CD   OE1  NE2                                  
REMARK 470     GLN C1486    CG   CD   OE1  NE2                                  
REMARK 470     ARG C1487    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN C1488    CG   CD   OE1  NE2                                  
REMARK 470     LEU C1489    CG   CD1  CD2                                       
REMARK 470     PHE C1490    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     CYS C1491    SG                                                  
REMARK 470     LEU C1492    CG   CD1  CD2                                       
REMARK 470     ARG C1494    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C1496    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL C1497    CG1  CG2                                            
REMARK 470     ARG C1498    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C1499    CG   CD   CE   NZ                                   
REMARK 470     THR C1500    OG1  CG2                                            
REMARK 470     ILE C1502    CG1  CG2  CD1                                       
REMARK 470     PHE C1503    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE C1504    CG1  CG2  CD1                                       
REMARK 470     MET C1505    CG   SD   CE                                        
REMARK 470     ASP C1506    CG   OD1  OD2                                       
REMARK 470     GLU C1507    CG   CD   OE1  OE2                                  
REMARK 470     THR C1509    OG1  CG2                                            
REMARK 470     SER C1511    OG                                                  
REMARK 470     ILE C1512    CG1  CG2  CD1                                       
REMARK 470     ASP C1513    CG   OD1  OD2                                       
REMARK 470     MET C1514    CG   SD   CE                                        
REMARK 470     THR C1516    OG1  CG2                                            
REMARK 470     GLU C1517    CG   CD   OE1  OE2                                  
REMARK 470     ASN C1518    CG   OD1  ND2                                       
REMARK 470     ILE C1519    CG1  CG2  CD1                                       
REMARK 470     LEU C1520    CG   CD1  CD2                                       
REMARK 470     GLN C1521    CG   CD   OE1  NE2                                  
REMARK 470     LYS C1522    CG   CD   CE   NZ                                   
REMARK 470     VAL C1523    CG1  CG2                                            
REMARK 470     VAL C1524    CG1  CG2                                            
REMARK 470     MET C1525    CG   SD   CE                                        
REMARK 470     THR C1526    OG1  CG2                                            
REMARK 470     PHE C1528    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP C1530    CG   OD1  OD2                                       
REMARK 470     ARG C1531    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C1532    OG1  CG2                                            
REMARK 470     VAL C1533    CG1  CG2                                            
REMARK 470     VAL C1534    CG1  CG2                                            
REMARK 470     THR C1535    OG1  CG2                                            
REMARK 470     ILE C1536    CG1  CG2  CD1                                       
REMARK 470     HIS C1538    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG C1539    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL C1540    CG1  CG2                                            
REMARK 470     THR C1542    OG1  CG2                                            
REMARK 470     ILE C1543    CG1  CG2  CD1                                       
REMARK 470     LEU C1544    CG   CD1  CD2                                       
REMARK 470     SER C1545    OG                                                  
REMARK 470     ASP C1547    CG   OD1  OD2                                       
REMARK 470     LEU C1548    CG   CD1  CD2                                       
REMARK 470     VAL C1549    CG1  CG2                                            
REMARK 470     MET C1550    CG   SD   CE                                        
REMARK 470     VAL C1551    CG1  CG2                                            
REMARK 470     LYS C1553    CG   CD   CE   NZ                                   
REMARK 470     ARG C1554    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C1557    CG1  CG2  CD1                                       
REMARK 470     LEU C1558    CG   CD1  CD2                                       
REMARK 470     GLU C1559    CG   CD   OE1  OE2                                  
REMARK 470     ASP C1561    CG   OD1  OD2                                       
REMARK 470     LYS C1562    CG   CD   CE   NZ                                   
REMARK 470     GLU C1564    CG   CD   OE1  OE2                                  
REMARK 470     THR C1565    OG1  CG2                                            
REMARK 470     LEU C1566    CG   CD1  CD2                                       
REMARK 470     LEU C1567    CG   CD1  CD2                                       
REMARK 470     SER C1568    OG                                                  
REMARK 470     GLN C1569    CG   CD   OE1  NE2                                  
REMARK 470     LYS C1570    CG   CD   CE   NZ                                   
REMARK 470     ASP C1571    CG   OD1  OD2                                       
REMARK 470     SER C1572    OG                                                  
REMARK 470     VAL C1573    CG1  CG2                                            
REMARK 470     PHE C1574    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER C1576    OG                                                  
REMARK 470     PHE C1577    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL C1578    CG1  CG2                                            
REMARK 470     MET D   1    CG   SD   CE                                        
REMARK 470     LEU D   2    CG   CD1  CD2                                       
REMARK 470     SER D   3    OG                                                  
REMARK 470     ARG D   4    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D   5    CG   CD   CE   NZ                                   
REMARK 470     ILE D   7    CG1  CG2  CD1                                       
REMARK 470     ILE D   8    CG1  CG2  CD1                                       
REMARK 470     PRO D   9    CG   CD                                             
REMARK 470     GLU D  10    CG   CD   OE1  OE2                                  
REMARK 470     GLU D  11    CG   CD   OE1  OE2                                  
REMARK 470     TYR D  12    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL D  13    CG1  CG2                                            
REMARK 470     LEU D  14    CG   CD1  CD2                                       
REMARK 470     THR D  15    OG1  CG2                                            
REMARK 470     ARG D  16    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU D  17    CG   CD1  CD2                                       
REMARK 470     GLU D  19    CG   CD   OE1  OE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU C 175   CA  -  CB  -  CG  ANGL. DEV. =  18.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    TYR C 107       15.43   -140.61                                   
REMARK 500    ASN C 131       91.40    -68.38                                   
REMARK 500    LYS C 252      -73.72    -76.98                                   
REMARK 500    LEU C 253      157.57    168.75                                   
REMARK 500    GLU C 330       -7.45     67.26                                   
REMARK 500    MET C 400        5.66    -68.20                                   
REMARK 500    THR C 404       51.13    -93.66                                   
REMARK 500    GLU C 568      -60.52   -101.91                                   
REMARK 500    SER C 572       76.90     51.36                                   
REMARK 500    ARG C 620     -176.94   -171.70                                   
REMARK 500    ILE C 693       75.68     54.76                                   
REMARK 500    PHE C 790       65.83     60.01                                   
REMARK 500    GLN C 847       64.35     60.94                                   
REMARK 500    ASP C 855       71.82     51.24                                   
REMARK 500    HIS C 896      -65.20    -95.57                                   
REMARK 500    ALA C 897       47.62   -142.38                                   
REMARK 500    TRP C 899       69.14   -102.34                                   
REMARK 500    GLN C 909      -61.51    -94.50                                   
REMARK 500    GLU C1275       68.63     60.94                                   
REMARK 500    ALA C1278       -4.66     69.06                                   
REMARK 500    LEU C1329       59.72    -94.26                                   
REMARK 500    LEU C1330     -168.03   -161.11                                   
REMARK 500    LYS C1344       37.32    -98.97                                   
REMARK 500    SER C1357      -60.41   -106.59                                   
REMARK 500    LYS C1385      -60.53    -90.07                                   
REMARK 500    ASP C1441       89.56   -153.46                                   
REMARK 500    GLN C1459     -177.57   -170.83                                   
REMARK 500    ARG C1531       -2.43     68.82                                   
REMARK 500    LYS C1570     -167.91    -77.23                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LYS C  252     LEU C  253                  132.03                    
REMARK 500 ILE C  996     PRO C  997                 -137.86                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GBM C 1601                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP C 1602                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20530   RELATED DB: EMDB                             
REMARK 900 RELATED ID: 6PZB   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 6PZ9   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 6PZI   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 6PZC   RELATED DB: PDB                                   
DBREF  6PZA C    1  1582  UNP    Q09427   ABCC8_CRICR      1   1582             
DBREF  6PZA D    1   390  UNP    P70673   KCJ11_RAT        1    390             
SEQADV 6PZA PRO D  191  UNP  P70673    LEU   191 CONFLICT                       
SEQRES   1 C 1582  MET PRO LEU ALA PHE CYS GLY THR GLU ASN HIS SER ALA          
SEQRES   2 C 1582  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 C 1582  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 C 1582  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 C 1582  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 C 1582  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 C 1582  PHE ILE LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 C 1582  GLY ILE LEU SER ASP GLY VAL THR GLU SER ARG HIS LEU          
SEQRES   9 C 1582  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 C 1582  ILE THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 C 1582  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU ILE TYR TRP          
SEQRES  12 C 1582  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 C 1582  PHE TYR ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 C 1582  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 C 1582  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 C 1582  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 C 1582  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 C 1582  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 C 1582  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 C 1582  ARG ALA ILE ALA LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 C 1582  THR ASN TYR GLN ARG LEU CYS VAL ALA PHE ASP ALA GLN          
SEQRES  22 C 1582  ALA ARG LYS ASP THR GLN SER PRO GLN GLY ALA ARG ALA          
SEQRES  23 C 1582  ILE TRP ARG ALA LEU CYS HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 C 1582  ILE LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 C 1582  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 C 1582  HIS LEU GLY LYS GLU ASN HIS VAL PHE GLN PRO LYS THR          
SEQRES  27 C 1582  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 C 1582  LEU GLY ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 C 1582  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 C 1582  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 C 1582  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS MET SER          
SEQRES  32 C 1582  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 C 1582  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 C 1582  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP THR MET PRO          
SEQRES  35 C 1582  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 C 1582  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 C 1582  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 C 1582  SER GLN ALA GLN ARG THR THR LEU GLU HIS SER ASN GLU          
SEQRES  39 C 1582  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY MET LYS          
SEQRES  40 C 1582  LEU LEU LYS LEU TYR ALA TRP GLU SER ILE PHE CYS SER          
SEQRES  41 C 1582  ARG VAL GLU VAL THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 C 1582  ARG ALA PHE ALA VAL TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 C 1582  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 C 1582  VAL GLY HIS VAL SER PHE PHE LYS GLU SER ASP LEU SER          
SEQRES  45 C 1582  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 C 1582  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 C 1582  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 C 1582  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 C 1582  ALA PRO ARG GLU PRO ALA PRO GLN GLY GLN ALA GLY LYS          
SEQRES  50 C 1582  TYR GLN ALA VAL PRO LEU LYS VAL VAL ASN ARG LYS ARG          
SEQRES  51 C 1582  PRO ALA ARG GLU GLU VAL ARG ASP LEU LEU GLY PRO LEU          
SEQRES  52 C 1582  GLN ARG LEU ALA PRO SER MET ASP GLY ASP ALA ASP ASN          
SEQRES  53 C 1582  PHE CYS VAL GLN ILE ILE GLY GLY PHE PHE THR TRP THR          
SEQRES  54 C 1582  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 C 1582  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 C 1582  GLY CYS GLY LYS SER SER LEU LEU LEU ALA THR LEU GLY          
SEQRES  57 C 1582  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP ASN SER          
SEQRES  58 C 1582  ASN LEU PRO ASP SER GLU GLY GLU ASP PRO SER SER PRO          
SEQRES  59 C 1582  GLU ARG GLU THR ALA ALA GLY SER ASP ILE ARG SER ARG          
SEQRES  60 C 1582  GLY PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU          
SEQRES  61 C 1582  ASN ALA THR VAL GLU GLU ASN ILE THR PHE GLU SER PRO          
SEQRES  62 C 1582  PHE ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS          
SEQRES  63 C 1582  SER LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP          
SEQRES  64 C 1582  GLN THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY          
SEQRES  65 C 1582  GLY GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR          
SEQRES  66 C 1582  GLN GLN THR ASN VAL VAL PHE LEU ASP ASP PRO PHE SER          
SEQRES  67 C 1582  ALA LEU ASP VAL HIS LEU SER ASP HIS LEU MET GLN ALA          
SEQRES  68 C 1582  GLY ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL          
SEQRES  69 C 1582  VAL LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA          
SEQRES  70 C 1582  ASP TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG          
SEQRES  71 C 1582  GLU GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN          
SEQRES  72 C 1582  LEU PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP          
SEQRES  73 C 1582  GLN GLU LEU GLU LYS GLU THR VAL MET GLU ARG LYS ALA          
SEQRES  74 C 1582  SER GLU PRO SER GLN GLY LEU PRO ARG ALA MET SER SER          
SEQRES  75 C 1582  ARG ASP GLY LEU LEU LEU ASP GLU GLU GLU GLU GLU GLU          
SEQRES  76 C 1582  GLU ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER          
SEQRES  77 C 1582  VAL LEU HIS GLN ARG ALA LYS ILE PRO TRP ARG ALA CYS          
SEQRES  78 C 1582  THR LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER          
SEQRES  79 C 1582  LEU LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU          
SEQRES  80 C 1582  VAL ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER          
SEQRES  81 C 1582  ALA LEU VAL LEU SER PRO ALA ALA ARG ASN CYS SER LEU          
SEQRES  82 C 1582  SER GLN GLU CYS ASP LEU ASP GLN SER VAL TYR ALA MET          
SEQRES  83 C 1582  VAL PHE THR LEU LEU CYS SER LEU GLY ILE VAL LEU CYS          
SEQRES  84 C 1582  LEU VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS          
SEQRES  85 C 1582  VAL ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE          
SEQRES  86 C 1582  ILE LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU          
SEQRES  87 C 1582  GLY SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR          
SEQRES  88 C 1582  ILE ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER          
SEQRES  89 C 1582  ARG SER THR LEU LEU CYS VAL SER ALA LEU THR VAL ILE          
SEQRES  90 C 1582  SER TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO          
SEQRES  91 C 1582  LEU ALA VAL VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG          
SEQRES  92 C 1582  VAL ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR          
SEQRES  93 C 1582  GLN LEU PRO LEU VAL SER HIS PHE ALA GLU THR VAL GLU          
SEQRES  94 C 1582  GLY LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG          
SEQRES  95 C 1582  PHE GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN          
SEQRES  96 C 1582  ILE ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU          
SEQRES  97 C 1582  GLU VAL CYS MET GLU TYR ILE GLY ALA CYS VAL VAL LEU          
SEQRES  98 C 1582  ILE ALA ALA ALA THR SER ILE SER ASN SER LEU HIS ARG          
SEQRES  99 C 1582  GLU LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR          
SEQRES 100 C 1582  ALA LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG          
SEQRES 101 C 1582  ASN LEU ALA ASP MET GLU ILE GLN LEU GLY ALA VAL LYS          
SEQRES 102 C 1582  ARG ILE HIS ALA LEU LEU LYS THR GLU ALA GLU SER TYR          
SEQRES 103 C 1582  GLU GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP          
SEQRES 104 C 1582  PRO ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL          
SEQRES 105 C 1582  ARG TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL          
SEQRES 106 C 1582  ASN THR LEU ILE SER PRO GLY GLN LYS ILE GLY ILE CYS          
SEQRES 107 C 1582  GLY ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA          
SEQRES 108 C 1582  PHE PHE ARG MET VAL ASP MET PHE GLU GLY ARG ILE ILE          
SEQRES 109 C 1582  ILE ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR          
SEQRES 110 C 1582  LEU ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL          
SEQRES 111 C 1582  LEU PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU          
SEQRES 112 C 1582  LYS LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU          
SEQRES 113 C 1582  ILE ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY          
SEQRES 114 C 1582  GLY LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE          
SEQRES 115 C 1582  SER GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA          
SEQRES 116 C 1582  PHE VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA          
SEQRES 117 C 1582  THR ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN          
SEQRES 118 C 1582  LYS VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL          
SEQRES 119 C 1582  THR ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP          
SEQRES 120 C 1582  LEU VAL MET VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE          
SEQRES 121 C 1582  ASP LYS PRO GLU THR LEU LEU SER GLN LYS ASP SER VAL          
SEQRES 122 C 1582  PHE ALA SER PHE VAL ARG ALA ASP LYS                          
SEQRES   1 D  390  MET LEU SER ARG LYS GLY ILE ILE PRO GLU GLU TYR VAL          
SEQRES   2 D  390  LEU THR ARG LEU ALA GLU ASP PRO THR GLU PRO ARG TYR          
SEQRES   3 D  390  ARG THR ARG GLU ARG ARG ALA ARG PHE VAL SER LYS LYS          
SEQRES   4 D  390  GLY ASN CYS ASN VAL ALA HIS LYS ASN ILE ARG GLU GLN          
SEQRES   5 D  390  GLY ARG PHE LEU GLN ASP VAL PHE THR THR LEU VAL ASP          
SEQRES   6 D  390  LEU LYS TRP PRO HIS THR LEU LEU ILE PHE THR MET SER          
SEQRES   7 D  390  PHE LEU CYS SER TRP LEU LEU PHE ALA MET VAL TRP TRP          
SEQRES   8 D  390  LEU ILE ALA PHE ALA HIS GLY ASP LEU ALA PRO GLY GLU          
SEQRES   9 D  390  GLY THR ASN VAL PRO CYS VAL THR SER ILE HIS SER PHE          
SEQRES  10 D  390  SER SER ALA PHE LEU PHE SER ILE GLU VAL GLN VAL THR          
SEQRES  11 D  390  ILE GLY PHE GLY GLY ARG MET VAL THR GLU GLU CYS PRO          
SEQRES  12 D  390  LEU ALA ILE LEU ILE LEU ILE VAL GLN ASN ILE VAL GLY          
SEQRES  13 D  390  LEU MET ILE ASN ALA ILE MET LEU GLY CYS ILE PHE MET          
SEQRES  14 D  390  LYS THR ALA GLN ALA HIS ARG ARG ALA GLU THR LEU ILE          
SEQRES  15 D  390  PHE SER LYS HIS ALA VAL ILE THR PRO ARG HIS GLY ARG          
SEQRES  16 D  390  LEU CYS PHE MET LEU ARG VAL GLY ASP LEU ARG LYS SER          
SEQRES  17 D  390  MET ILE ILE SER ALA THR ILE HIS MET GLN VAL VAL ARG          
SEQRES  18 D  390  LYS THR THR SER PRO GLU GLY GLU VAL VAL PRO LEU HIS          
SEQRES  19 D  390  GLN VAL ASP ILE PRO MET GLU ASN GLY VAL GLY GLY ASN          
SEQRES  20 D  390  SER ILE PHE LEU VAL ALA PRO LEU ILE ILE TYR HIS VAL          
SEQRES  21 D  390  ILE ASP SER ASN SER PRO LEU TYR ASP LEU ALA PRO SER          
SEQRES  22 D  390  ASP LEU HIS HIS HIS GLN ASP LEU GLU ILE ILE VAL ILE          
SEQRES  23 D  390  LEU GLU GLY VAL VAL GLU THR THR GLY ILE THR THR GLN          
SEQRES  24 D  390  ALA ARG THR SER TYR LEU ALA ASP GLU ILE LEU TRP GLY          
SEQRES  25 D  390  GLN ARG PHE VAL PRO ILE VAL ALA GLU GLU ASP GLY ARG          
SEQRES  26 D  390  TYR SER VAL ASP TYR SER LYS PHE GLY ASN THR VAL LYS          
SEQRES  27 D  390  VAL PRO THR PRO LEU CYS THR ALA ARG GLN LEU ASP GLU          
SEQRES  28 D  390  ASP ARG SER LEU LEU ASP ALA LEU THR LEU ALA SER SER          
SEQRES  29 D  390  ARG GLY PRO LEU ARG LYS ARG SER VAL ALA VAL ALA LYS          
SEQRES  30 D  390  ALA LYS PRO LYS PHE SER ILE SER PRO ASP SER LEU SER          
HET    GBM  C1601      33                                                       
HET    ATP  C1602      31                                                       
HETNAM     GBM 5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)                          
HETNAM   2 GBM  SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE                      
HETNAM     ATP ADENOSINE-5'-TRIPHOSPHATE                                        
HETSYN     GBM GLIBENCLAMIDE, GLYBURIDE                                         
FORMUL   3  GBM    C23 H28 CL N3 O5 S                                           
FORMUL   4  ATP    C10 H16 N5 O13 P3                                            
HELIX    1 AA1 SER C   12  ARG C   16  5                                   5    
HELIX    2 AA2 CYS C   26  SER C   55  1                                  30    
HELIX    3 AA3 VAL C   58  SER C   63  5                                   6    
HELIX    4 AA4 HIS C   71  GLY C   97  1                                  27    
HELIX    5 AA5 MET C  108  SER C  130  1                                  23    
HELIX    6 AA6 PHE C  132  LEU C  135  5                                   4    
HELIX    7 AA7 LEU C  136  HIS C  160  1                                  25    
HELIX    8 AA8 GLN C  166  ARG C  194  1                                  29    
HELIX    9 AA9 PRO C  207  ASP C  212  1                                   6    
HELIX   10 AB1 ASN C  223  TYR C  230  1                                   8    
HELIX   11 AB2 TRP C  232  LYS C  238  1                                   7    
HELIX   12 AB3 THR C  239  LYS C  242  5                                   4    
HELIX   13 AB4 PRO C  254  MET C  257  5                                   4    
HELIX   14 AB5 ARG C  258  ASP C  277  1                                  20    
HELIX   15 AB6 GLY C  283  PHE C  314  1                                  32    
HELIX   16 AB7 GLY C  316  GLY C  328  1                                  13    
HELIX   17 AB8 LYS C  329  HIS C  332  5                                   4    
HELIX   18 AB9 SER C  347  LEU C  352  1                                   6    
HELIX   19 AC1 ALA C  355  LYS C  398  1                                  44    
HELIX   20 AC2 THR C  413  PHE C  432  1                                  20    
HELIX   21 AC3 PRO C  436  LEU C  456  1                                  21    
HELIX   22 AC4 GLY C  457  ILE C  468  1                                  12    
HELIX   23 AC5 LEU C  470  ARG C  504  1                                  35    
HELIX   24 AC6 GLY C  505  TYR C  512  1                                   8    
HELIX   25 AC7 GLU C  515  SER C  564  1                                  50    
HELIX   26 AC8 SER C  572  SER C  615  1                                  44    
HELIX   27 AC9 GLY C  718  LEU C  727  1                                  10    
HELIX   28 AD1 GLU C  785  PHE C  790  1                                   6    
HELIX   29 AD2 ASN C  795  CYS C  806  1                                  12    
HELIX   30 AD3 LEU C  808  LEU C  815  1                                   8    
HELIX   31 AD4 SER C  831  GLN C  846  1                                  16    
HELIX   32 AD5 VAL C  862  ASP C  879  1                                  18    
HELIX   33 AD6 ILE C  996  GLY C 1009  1                                  14    
HELIX   34 AD7 GLY C 1009  VAL C 1043  1                                  35    
HELIX   35 AD8 GLN C 1061  LEU C 1107  1                                  47    
HELIX   36 AD9 PRO C 1109  THR C 1116  1                                   8    
HELIX   37 AE1 PRO C 1117  HIS C 1135  1                                  19    
HELIX   38 AE2 HIS C 1135  THR C 1161  1                                  27    
HELIX   39 AE3 VAL C 1163  GLY C 1210  1                                  48    
HELIX   40 AE4 GLY C 1210  ARG C 1218  1                                   9    
HELIX   41 AE5 TYR C 1219  HIS C 1273  1                                  55    
HELIX   42 AE6 ALA C 1278  SER C 1292  1                                  15    
HELIX   43 AE7 TYR C 1294  LYS C 1320  1                                  27    
HELIX   44 AE8 LYS C 1385  PHE C 1392  1                                   8    
HELIX   45 AE9 PRO C 1414  ARG C 1419  1                                   6    
HELIX   46 AF1 THR C 1435  ASP C 1441  1                                   7    
HELIX   47 AF2 SER C 1447  ALA C 1458  1                                  12    
HELIX   48 AF3 LEU C 1460  LYS C 1465  1                                   6    
HELIX   49 AF4 GLN C 1484  ARG C 1498  1                                  15    
HELIX   50 AF5 ILE C 1512  ARG C 1531  1                                  20    
HELIX   51 AF6 ARG C 1539  ILE C 1543  5                                   5    
HELIX   52 AF7 GLU C 1564  LYS C 1570  1                                   7    
HELIX   53 AF8 ASP C 1571  VAL C 1578  1                                   8    
SHEET    1 AA1 2 THR C 338  PHE C 340  0                                        
SHEET    2 AA1 2 VAL C 343  PHE C 345 -1  O  VAL C 343   N  PHE C 340           
SHEET    1 AA2 3 ARG C 702  ILE C 703  0                                        
SHEET    2 AA2 3 VAL C 679  ILE C 681 -1  N  VAL C 679   O  ILE C 703           
SHEET    3 AA2 3 VAL C 737  PHE C 738 -1  O  PHE C 738   N  GLN C 680           
SHEET    1 AA3 5 PHE C 852  LEU C 853  0                                        
SHEET    2 AA3 5 VAL C 884  VAL C 887  1  O  VAL C 885   N  LEU C 853           
SHEET    3 AA3 5 LEU C 708  GLY C 713  1  N  ILE C 711   O  LEU C 886           
SHEET    4 AA3 5 ILE C 901  LYS C 904  1  O  ILE C 901   N  VAL C 712           
SHEET    5 AA3 5 THR C 907  GLU C 911 -1  O  GLN C 909   N  ALA C 902           
SHEET    1 AA4 4 ASN C1366  LEU C1368  0                                        
SHEET    2 AA4 4 GLN C1346  GLN C1348 -1  N  ILE C1347   O  THR C1367           
SHEET    3 AA4 4 ARG C1402  ILE C1405 -1  O  ARG C1402   N  GLN C1348           
SHEET    4 AA4 4 ILE C1408  ASP C1409 -1  O  ILE C1408   N  ILE C1405           
SHEET    1 AA5 2 VAL C1352  ARG C1353  0                                        
SHEET    2 AA5 2 ASP C1397  MET C1398 -1  O  ASP C1397   N  ARG C1353           
SHEET    1 AA6 2 ILE C1375  GLY C1376  0                                        
SHEET    2 AA6 2 VAL C1534  THR C1535  1  N  THR C1535   O  ILE C1375           
SHEET    1 AA7 2 LEU C1422  ILE C1424  0                                        
SHEET    2 AA7 2 ILE C1502  ILE C1504  1  O  ILE C1504   N  SER C1423           
SHEET    1 AA8 2 VAL C1549  VAL C1551  0                                        
SHEET    2 AA8 2 GLU C1559  ASP C1561 -1  O  ASP C1561   N  VAL C1549           
SSBOND   1 CYS C    6    CYS C   26                          1555   1555  2.02  
CISPEP   1 LEU C  571    SER C  572          0        23.73                     
SITE     1 AC1 15 ARG C 306  TYR C 377  ILE C 381  PHE C 433                    
SITE     2 AC1 15 LEU C 434  ASN C 437  LEU C 592  SER C1238                    
SITE     3 AC1 15 LEU C1241  THR C1242  ASN C1245  ARG C1246                    
SITE     4 AC1 15 ARG C1300  ARG D   4  LYS D   5                               
SITE     1 AC2  9 THR C 404  TRP C 688  GLY C 716  CYS C 717                    
SITE     2 AC2  9 GLY C 718  LYS C 719  SER C 720  SER C 721                    
SITE     3 AC2  9 GLN C 775                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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