#=GF ID A2M_BRD
#=GF AC PF07703.18
#=GF DE Alpha-2-macroglobulin bait region domain
#=GF PI A2M_N_2;
#=GF AU Studholme DJ;0000-0002-3010-6637
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Prosite
#=GF GA 22.70 22.70;
#=GF TC 22.70 22.70;
#=GF NC 22.60 22.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF WK Alpha-2-Macroglobulin
#=GF CL CL0159
#=GF RN [1]
#=GF RM 25221932
#=GF RT Structure of a bacterial alpha2-macroglobulin reveals mimicry of
#=GF RT eukaryotic innate immunity.
#=GF RA Wong SG, Dessen A;
#=GF RL Nat Commun. 2014;5:4917.
#=GF RN [2]
#=GF RM 22290936
#=GF RT The crystal structure of human alpha2-macroglobulin reveals a
#=GF RT unique molecular cage.
#=GF RA Marrero A, Duquerroy S, Trapani S, Goulas T, Guevara T, Andersen
#=GF RA GR, Navaza J, Sottrup-Jensen L, Gomis-Ruth FX;
#=GF RL Angew Chem Int Ed Engl. 2012;51:3340-3344.
#=GF DR INTERPRO; IPR011625;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and
#=GF CC inhibit a broad range of proteases and are major components of
#=GF CC the eukaryotic innate immune system. However, A2M-like proteins
#=GF CC were identified in pathogenically invasive bacteria and species
#=GF CC that colonize higher eukaryotes. This domain is found in
#=GF CC eukaryotic and bacterial proteins. In human A2Ms, this domain
#=GF CC encompasses macroglobulin-like domain MG5 and 6 including bait
#=GF CC region. In Salmonella enterica ser A2Ms, this domain encompasses
#=GF CC MG7 and MG8 including the bait region [1] [2]. The Bait region
#=GF CC is cleaved by proteases, followed by a large conformational
#=GF CC change that blocks the target protease within a cage-like
#=GF CC complex. This model of protease entrapment is recognised as the
#=GF CC Venus flytrap mechanism [1].
#=GF SQ 13962
#=GS Q28VT1_JANSC/939-1083 AC Q28VT1.1
#=GS A0A673LCS8_9TELE/439-580 AC A0A673LCS8.1
#=GS A0A498CZI6_9FIRM/941-1075 AC A0A498CZI6.1
#=GS A0A8J4X4W3_CLAMG/1550-1699 AC A0A8J4X4W3.1
#=GS A0A5C4RSZ4_9GAMM/742-885 AC A0A5C4RSZ4.1
#=GS A0A8C9X0E0_SANLU/457-597 AC A0A8C9X0E0.1
#=GS A0A2K9PSW7_9FLAO/993-1135 AC A0A2K9PSW7.1
#=GS A0A7N6ADL5_ANATE/196-334 AC A0A7N6ADL5.1
#=GS A0A4Z2F004_9TELE/258-406 AC A0A4Z2F004.1
#=GS A0A667IIH8_LYNCA/449-570 AC A0A667IIH8.1
#=GS A0A2T4V8Z6_VITXG/972-1114 AC A0A2T4V8Z6.1
#=GS A0A668V7J9_OREAU/453-593 AC A0A668V7J9.1
#=GS A0A2W2AFD1_9BACT/932-1070 AC A0A2W2AFD1.1
#=GS A0A7L4ZWV1_9BACT/955-1094 AC A0A7L4ZWV1.1
#=GS A0A668VFB4_OREAU/454-595 AC A0A668VFB4.1
#=GS A0A3T0ECQ1_9PROT/758-902 AC A0A3T0ECQ1.1
#=GS A0A452SFB2_URSAM/462-611 AC A0A452SFB2.1
#=GS A0A8D2N1R1_ZONAL/469-610 AC A0A8D2N1R1.1
#=GS A0A4R7BLR2_9HYPH/889-1033 AC A0A4R7BLR2.1
#=GS A0A7K9TPI4_9AVES/1-86 AC A0A7K9TPI4.1
#=GS A0A8C0G2Z4_CHEAB/447-594 AC A0A8C0G2Z4.1
#=GS A0A8C6RYU6_NANGA/453-602 AC A0A8C6RYU6.1
#=GS A0A7K9KWU6_9PASS/457-597 AC A0A7K9KWU6.1
#=GS A0A7L2T1A4_POMRU/2-88 AC A0A7L2T1A4.1
#=GS A0A7L3CMA6_PELUR/1-86 AC A0A7L3CMA6.1
#=GS A0A8J1JLK2_XENTR/448-575 AC A0A8J1JLK2.1
#=GS A0A7L3X816_9AVES/1-86 AC A0A7L3X816.1
#=GS A0A7K5QSX5_9PASE/427-599 AC A0A7K5QSX5.1
#=GS A0A239T1B9_9BURK/1056-1240 AC A0A239T1B9.1
#=GS A0A4W4F1F1_ELEEL/413-563 AC A0A4W4F1F1.1
#=GS A0A126UY30_9RHOB/949-1093 AC A0A126UY30.1
#=GS A0A8D2CPP0_SCIVU/391-522 AC A0A8D2CPP0.1
#=GS A0A6I9ZE33_GEOFO/564-711 AC A0A6I9ZE33.1
#=GS A0A7K5A9G2_9AVES/470-617 AC A0A7K5A9G2.1
#=GS A0A3Q1AKL5_AMPOC/449-584 AC A0A3Q1AKL5.1
#=GS A0A4W6DW87_LATCA/454-594 AC A0A4W6DW87.1
#=GS D8IZT7_HERSS/1014-1193 AC D8IZT7.1
#=GS A0A6A5ED68_PERFL/489-617 AC A0A6A5ED68.1
#=GS A0A411HIK3_9GAMM/1104-1243 AC A0A411HIK3.1
#=GS A0A7K5I9P3_CROSL/199-346 AC A0A7K5I9P3.1
#=GS A0A6J2LLJ7_9CHIR/468-599 AC A0A6J2LLJ7.1
#=GS A0A7V7PSI7_9HYPH/964-1108 AC A0A7V7PSI7.1
#=GS A0A1L3SUG4_9HYPH/954-1098 AC A0A1L3SUG4.1
#=GS A0A1G4G3K1_9BACT/999-1142 AC A0A1G4G3K1.1
#=GS A0A8D2EH13_THEGE/459-607 AC A0A8D2EH13.1
#=GS A0A803VFG6_FICAL/429-569 AC A0A803VFG6.1
#=GS A0A6A5C9T2_NAEFO/4-96 AC A0A6A5C9T2.1
#=GS A0A444SBJ6_ARMVU/530-666 AC A0A444SBJ6.1
#=GS A0A087TFS2_STEMI/2-89 AC A0A087TFS2.1
#=GS A0A6J2GWP1_9PASS/460-608 AC A0A6J2GWP1.2
#=GS A0A803VZN8_FICAL/462-612 AC A0A803VZN8.1
#=GS A0A4W6DTQ0_LATCA/453-590 AC A0A4W6DTQ0.1
#=GS E2ACP6_CAMFO/306-441 AC E2ACP6.1
#=GS A0A540VKD4_9CHLR/1094-1242 AC A0A540VKD4.1
#=GS A0A6P7SZ87_OCTVU/469-603 AC A0A6P7SZ87.1
#=GS A0A7K8L7N2_9GRUI/455-595 AC A0A7K8L7N2.1
#=GS A0A850Y360_AEGCA/450-595 AC A0A850Y360.1
#=GS R7VGJ0_CAPTE/186-318 AC R7VGJ0.1
#=GS A0A8I3WJK9_CALJA/473-575 AC A0A8I3WJK9.1
#=GS A0A8C3Q762_GEOPR/452-592 AC A0A8C3Q762.1
#=GS G1KQP2_ANOCA/432-582 AC G1KQP2.3
#=GS A0A7K7P4B2_ACRAR/426-569 AC A0A7K7P4B2.1
#=GS A0A6M0CN47_9FLAO/972-1114 AC A0A6M0CN47.1
#=GS A0A3Q0CWH1_MESAU/468-599 AC A0A3Q0CWH1.1
#=GS A0A1G6UDP6_9GAMM/733-877 AC A0A1G6UDP6.1
#=GS A0A8C6P943_NOTFU/445-590 AC A0A8C6P943.1
#=GS A9EVK9_SORC5/565-705 AC A9EVK9.1
#=GS A0A7M7N8T4_STRPU/606-704 AC A0A7M7N8T4.1
#=GS A0A3B1K9L2_ASTMX/547-689 AC A0A3B1K9L2.1
#=GS A0A7K5FJJ1_PROAR/1-86 AC A0A7K5FJJ1.1
#=GS A0A7Y2SMP0_9CHLR/1280-1431 AC A0A7Y2SMP0.1
#=GS A0A7L2H9A1_SAGSE/367-517 AC A0A7L2H9A1.1
#=GS A0A8J8M7P2_9FIRM/831-976 AC A0A8J8M7P2.1
#=GS A0A7L1G282_9PICI/325-455 AC A0A7L1G282.1
#=GS A0A0D6JD64_9HYPH/879-1023 AC A0A0D6JD64.1
#=GS A0A4Y6PSG9_9DELT/1008-1150 AC A0A4Y6PSG9.1
#=GS A0A7N4PES7_SARHA/471-609 AC A0A7N4PES7.1
#=GS A0A6G0IM23_LARCR/339-483 AC A0A6G0IM23.1
#=GS A0A7L2LB30_9SYLV/1-86 AC A0A7L2LB30.1
#=GS A0A7L2A5U3_LEILU/447-595 AC A0A7L2A5U3.1
#=GS A0A8D0A7S7_SANLU/423-563 AC A0A8D0A7S7.1
#=GS A0A267EVS7_9PLAT/496-633 AC A0A267EVS7.1
#=GS I0HYK8_CALAS/1077-1234 AC I0HYK8.1
#=GS A0A7L2GQS8_NYCGR/458-598 AC A0A7L2GQS8.1
#=GS A0A673HXK8_9TELE/471-610 AC A0A673HXK8.1
#=GS I3KHY2_ORENI/445-581 AC I3KHY2.2
#=GS B2FQH1_STRMK/741-884 AC B2FQH1.1
#=GS A0A3Q7RF17_VULVU/455-604 AC A0A3Q7RF17.1
#=GS G1KYH5_ANOCA/217-348 AC G1KYH5.3
#=GS A0A7L3P6I6_9DEND/454-599 AC A0A7L3P6I6.1
#=GS A0A093IJU7_FULGA/2-88 AC A0A093IJU7.1
#=GS A0A6F9CIY6_9TELE/191-307 AC A0A6F9CIY6.1
#=GS A0A484DK74_PERFV/428-568 AC A0A484DK74.1
#=GS A0A443QUC4_9ACAR/364-505 AC A0A443QUC4.1
#=GS A0A671SI92_9TELE/466-613 AC A0A671SI92.1
#=GS A0A851S4M7_CERFA/360-509 AC A0A851S4M7.1
#=GS A0A6J1VHQ2_9SAUR/471-616 AC A0A6J1VHQ2.1
#=GS A0A672IMY8_SALFA/435-575 AC A0A672IMY8.1
#=GS A0A318N0P1_9PROT/730-878 AC A0A318N0P1.1
#=GS A0A7L3A392_9PASE/469-616 AC A0A7L3A392.1
#=GS A0A665W6E0_ECHNA/448-589 AC A0A665W6E0.1
#=GS A0A7K8QW39_9PASS/465-612 AC A0A7K8QW39.1
#=GS B1M1U4_METRJ/897-1041 AC B1M1U4.1
#=GS A0A669CGD4_ORENI/432-572 AC A0A669CGD4.1
#=GS A0A6G0IEP3_LARCR/443-568 AC A0A6G0IEP3.1
#=GS A0A239EFR1_9BACT/597-761 AC A0A239EFR1.1
#=GS A0A7K8YDT2_9PASS/367-517 AC A0A7K8YDT2.1
#=GS A0A8J5JTT8_HOMAM/420-548 AC A0A8J5JTT8.1
#=GS A0A3P8SW39_AMPPE/410-550 AC A0A3P8SW39.1
#=GS A0A2K5U1T1_MACFA/467-612 AC A0A2K5U1T1.2
#=GS J7U6T4_MORMO/778-927 AC J7U6T4.1
#=GS W5MEU5_LEPOC/414-587 AC W5MEU5.1
#=GS A0A1S1T063_9HYPH/951-1095 AC A0A1S1T063.1
#=GS A0A7K7ULV6_9CHAR/1-86 AC A0A7K7ULV6.1
#=GS S7NZS4_MYOBR/454-606 AC S7NZS4.1
#=GS A0A8C7GJC1_ONCKI/466-606 AC A0A8C7GJC1.1
#=GS A0A073IRG4_9BACT/903-1045 AC A0A073IRG4.1
#=GS A0A665VYT6_ECHNA/453-593 AC A0A665VYT6.1
#=GS A0A7K4VFA9_9EMBE/1-86 AC A0A7K4VFA9.1
#=GS A0A6A5FFR2_PERFL/457-597 AC A0A6A5FFR2.1
#=GS A0A8C7B2U3_NEOVI/471-610 AC A0A8C7B2U3.1
#=GS A0A2R7LJJ6_9FLAO/1027-1169 AC A0A2R7LJJ6.1
#=GS A0A7L2REE6_9PASS/1-41 AC A0A7L2REE6.1
#=GS A0A6B3P1X5_9PSED/683-831 AC A0A6B3P1X5.1
#=GS A0A099PF21_9GAMM/193-338 AC A0A099PF21.1
#=GS A0A8C9FYV7_PAVCR/389-560 AC A0A8C9FYV7.1
#=GS D5AST4_RHOCB/948-1093 AC D5AST4.1
#=GS A0A7K6J844_9CORV/465-596 AC A0A7K6J844.1
#=GS A0A521CKK3_9BACT/977-1119 AC A0A521CKK3.1
#=GS A0A2A3C913_9HYPH/958-1102 AC A0A2A3C913.1
#=GS J6L930_9RHOB/878-1022 AC J6L930.1
#=GS A0A8C8SGX9_9SAUR/464-604 AC A0A8C8SGX9.1
#=GS A0A8B9N5B1_9AVES/469-614 AC A0A8B9N5B1.1
#=GS A0A218ULC2_9PASE/354-502 AC A0A218ULC2.1
#=GS A0A8C8SGL1_9SAUR/418-568 AC A0A8C8SGL1.1
#=GS A0A8C6PAI1_NOTFU/521-666 AC A0A8C6PAI1.1
#=GS A0A8U8B4N5_GEOPR/431-573 AC A0A8U8B4N5.1
#=GS A0A811Z3M4_NYCPR/447-593 AC A0A811Z3M4.1
#=GS A0A673L7G3_9TELE/448-589 AC A0A673L7G3.1
#=GS A0A8C4UZH8_FALTI/404-539 AC A0A8C4UZH8.1
#=GS A0A8C4Y6V0_9SAUR/390-537 AC A0A8C4Y6V0.1
#=GS A0A2S8SQL3_9BACT/588-727 AC A0A2S8SQL3.1
#=GS A0A7L2ELP8_ANTMN/1-86 AC A0A7L2ELP8.1
#=GS A0A8C8GKI5_ONCTS/344-485 AC A0A8C8GKI5.1
#=GS A0A8C4AFD3_9TELE/465-614 AC A0A8C4AFD3.1
#=GS A0A6I9N4Q2_9TELE/124-272 AC A0A6I9N4Q2.1
#=GS A0A553R7V1_9TELE/505-656 AC A0A553R7V1.1
#=GS A0A0A0A563_CHAVO/384-515 AC A0A0A0A563.1
#=GS A0A8C5UMN3_MICMU/467-612 AC A0A8C5UMN3.1
#=GS A0A2A4K5L5_HELVI/272-406 AC A0A2A4K5L5.1
#=GS A0A673XW19_SALTR/401-537 AC A0A673XW19.1
#=GS A0A7L2LC90_9SYLV/422-570 AC A0A7L2LC90.1
#=GS A0A5J5N8N6_MUNRE/455-624 AC A0A5J5N8N6.1
#=GS A0A553P9E9_9TELE/486-616 AC A0A553P9E9.1
#=GS G1KQS3_ANOCA/454-601 AC G1KQS3.3
#=GS A0A7L3TJV8_RISTR/1-86 AC A0A7L3TJV8.1
#=GS A0A7L1V4P4_SITEU/438-609 AC A0A7L1V4P4.1
#=GS A0A1W0WV32_HYPDU/489-627 AC A0A1W0WV32.1
#=GS A0A6J1XE80_ACIJB/412-557 AC A0A6J1XE80.1
#=GS A0A1M6ELJ8_9FIRM/810-952 AC A0A1M6ELJ8.1
#=GS A0A250KUV2_9GAMM/689-835 AC A0A250KUV2.1
#=GS A0A671XKL0_SPAAU/424-562 AC A0A671XKL0.1
#=GS A0A8D0KLD1_SALMN/442-588 AC A0A8D0KLD1.1
#=GS A0A3D9YYF0_9HYPH/865-1009 AC A0A3D9YYF0.1
#=GS A0A8C4XPR7_FALTI/460-607 AC A0A8C4XPR7.1
#=GS A0A453YTR1_ANOGA/456-592 AC A0A453YTR1.1
#=GS A0A5C6YG45_9FLAO/975-1114 AC A0A5C6YG45.1
#=GS I3LQ17_PIG/383-499 AC I3LQ17.4
#=GS A0A7K5A8A1_9AVES/450-596 AC A0A7K5A8A1.1
#=GS A0A7K8ZQ00_9PASS/451-599 AC A0A7K8ZQ00.1
#=GS A0A1S3A0I5_ERIEU/471-610 AC A0A1S3A0I5.1
#=GS A0A8J5TH46_HOMAM/620-790 AC A0A8J5TH46.1
#=GS H7EI00_9SPIR/1044-1186 AC H7EI00.1
#=GS A0A210R3J1_MIZYE/535-670 AC A0A210R3J1.1
#=GS A0A3N7EGW5_9BURK/1061-1242 AC A0A3N7EGW5.1
#=GS A0A4R3N5Z7_9GAMM/955-1103 AC A0A4R3N5Z7.1
#=GS A0A667HI57_LYNCA/403-551 AC A0A667HI57.1
#=GS A0A6I9ZB03_GEOFO/464-610 AC A0A6I9ZB03.1
#=GS A0A6L9ED04_9FLAO/978-1120 AC A0A6L9ED04.1
#=GS A0A3Q1I8X8_ANATE/397-547 AC A0A3Q1I8X8.2
#=GS A0A0Q9WX21_DROVI/449-583 AC A0A0Q9WX21.1
#=GS A0A851KFP0_VIDCH/439-570 AC A0A851KFP0.1
#=GS V5WF44_9SPIO/1066-1220 AC V5WF44.1
#=GS A0A8C4SYC4_ERPCA/452-600 AC A0A8C4SYC4.1
#=GS A0A8U8BTF2_GEOPR/454-625 AC A0A8U8BTF2.1
#=GS A0A8C3K089_9CHAR/417-564 AC A0A8C3K089.1
#=GS A0A7K9URK3_ANSSE/429-600 AC A0A7K9URK3.1
#=GS F1MJK3_BOVIN/452-600 AC F1MJK3.3
#=GS A0A1Q3GLH0_9BACT/937-1078 AC A0A1Q3GLH0.1
#=GS A0A8K0KYF6_LADFU/137-276 AC A0A8K0KYF6.1
#=GS A0A674E519_SALTR/462-570 AC A0A674E519.1
#=GS A0A7N9B151_9TELE/374-518 AC A0A7N9B151.1
#=GS A0A091QZC2_9GRUI/451-598 AC A0A091QZC2.1
#=GS A0A545SND9_9GAMM/1016-1171 AC A0A545SND9.1
#=GS A0A2U9BQ34_SCOMX/457-597 AC A0A2U9BQ34.1
#=GS A0A1S3SY52_SALSA/84-231 AC A0A1S3SY52.1
#=GS A0A7W6J589_9HYPH/966-1110 AC A0A7W6J589.1
#=GS M7BYF7_CHEMY/68-192 AC M7BYF7.1
#=GS A0A7M5X2S4_9CNID/487-681 AC A0A7M5X2S4.1
#=GS F4GUR9_PUSST/1053-1236 AC F4GUR9.1
#=GS A0A4U5UIE3_COLLU/446-556 AC A0A4U5UIE3.1
#=GS A0A4U1FPJ1_MONMO/428-576 AC A0A4U1FPJ1.1
#=GS A0A7M4F5T1_CROPO/463-594 AC A0A7M4F5T1.1
#=GS A0A8B9MWH6_9AVES/155-286 AC A0A8B9MWH6.1
#=GS A0A087VFR6_BALRE/1-88 AC A0A087VFR6.1
#=GS A0A851RY85_CERFA/458-598 AC A0A851RY85.1
#=GS A0A6P8S188_GEOSA/447-614 AC A0A6P8S188.1
#=GS A0A3Q3VJG1_MOLML/459-594 AC A0A3Q3VJG1.1
#=GS A0A820VLK9_9BILA/527-656 AC A0A820VLK9.1
#=GS A0A212Q1F1_9PROT/709-849 AC A0A212Q1F1.1
#=GS A0A8C9LGJ9_PAVCR/209-351 AC A0A8C9LGJ9.1
#=GS A0A6P8J3B6_ACTTE/489-626 AC A0A6P8J3B6.1
#=GS A0A8C1I216_CYPCA/450-577 AC A0A8C1I216.1
#=GS A0A093ELA0_TYTAL/458-598 AC A0A093ELA0.1
#=GS A0A6J2QUP3_COTGO/471-617 AC A0A6J2QUP3.1
#=GS A0A2I4CQ83_9TELE/1-75 AC A0A2I4CQ83.1
#=GS A0A3A6TBX0_9GAMM/723-874 AC A0A3A6TBX0.1
#=GS A0A8P0S986_CANLF/467-612 AC A0A8P0S986.1
#=GS A0A8C5J3R2_JUNHY/433-580 AC A0A8C5J3R2.1
#=GS A0A0H3CDR9_CAUVN/806-950 AC A0A0H3CDR9.1
#=GS A0A3Q0HI63_ALLSI/470-623 AC A0A3Q0HI63.1
#=GS A0A673K2P4_9TELE/413-562 AC A0A673K2P4.1
#=GS A0A7K9TQI7_9AVES/360-510 AC A0A7K9TQI7.1
#=GS A0A8C5B239_GADMO/439-578 AC A0A8C5B239.1
#=GS A0A7H0GR45_9BACT/208-348 AC A0A7H0GR45.1
#=GS G1MQH1_MELGA/449-597 AC G1MQH1.3
#=GS A0A671Y7G8_SPAAU/455-593 AC A0A671Y7G8.1
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