#=GF ID   AAA_7
#=GF AC   PF12775.11
#=GF DE   P-loop containing dynein motor region
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Pfam-B_14 (release 24.0)
#=GF GA   25.80 25.80;
#=GF TC   25.80 25.80;
#=GF NC   25.70 25.70;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF WK   AAA_proteins
#=GF CL   CL0023
#=GF RN   [1]
#=GF RM   25470043
#=GF RT   Structure of human cytoplasmic dynein-2 primed for its power
#=GF RT   stroke.
#=GF RA   Schmidt H, Zalyte R, Urnavicius L, Carter AP;
#=GF RL   Nature. 2015;518:435-438.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in human cytoplasmic dynein-2 proteins.
#=GF CC   Cytoplasmic dynein-2 (dynein-2) performs intraflagellar
#=GF CC   transport and is associated with human skeletal ciliophathies.
#=GF CC   Dyneins share a conserved motor domain that couples cycles of
#=GF CC   ATP hydrolysis with conformational changes to produce movement.
#=GF CC   Structural analysis reveal that the motor's ring consists of six
#=GF CC   AAA+ domains (ATPases associated with various cellular
#=GF CC   activities (AAA1-AAA6). This is the third nucleotide binding
#=GF CC   sites in the dynein motor. However, AAA3 has lost the catalytic
#=GF CC   residues necessary for ATP hydrolysis (the Walker B glutamate,
#=GF CC   the arginine finger, sensor-I and sensor-II motifs) [1].
#=GF SQ   15930
#=GS A0A507EGC3_9FUNG/2487-2665  AC A0A507EGC3.1
#=GS A0A662XTF2_9STRA/781-964    AC A0A662XTF2.1
#=GS A0A3R7Q852_PENVA/1268-1449  AC A0A3R7Q852.1
#=GS A0A1W0A8D9_9STRA/2224-2405  AC A0A1W0A8D9.1
#=GS A0A6J1Y5T3_ACIJB/2634-2815  AC A0A6J1Y5T3.1
#=GS I7MH00_TETTS/2107-2287      AC I7MH00.2
#=GS A0A8C3CYP4_CAIMO/2116-2297  AC A0A8C3CYP4.1
#=GS A0A835W4Q2_CHLIN/2092-2272  AC A0A835W4Q2.1
#=GS A0A7L4BF08_9CHAR/2300-2479  AC A0A7L4BF08.1
#=GS A0A852DIR6_PASAF/1913-2093  AC A0A852DIR6.1
#=GS A0A813RN96_9BILA/2266-2447  AC A0A813RN96.1
#=GS A0A8C3IAS8_CHRPI/1156-1337  AC A0A8C3IAS8.1
#=GS V6LE55_9EUKA/2463-2596      AC V6LE55.1
#=GS A0A1Y2HJK7_9FUNG/1854-2012  AC A0A1Y2HJK7.1
#=GS A0A7E4W7E9_PANRE/1762-1901  AC A0A7E4W7E9.1
#=GS A0A671FT15_RHIFE/2415-2594  AC A0A671FT15.1
#=GS A0A6I9LJ79_PERMB/2317-2488  AC A0A6I9LJ79.1
#=GS A0A8D0E563_SALMN/1219-1400  AC A0A8D0E563.1
#=GS G3QD10_GORGO/2557-2739      AC G3QD10.2
#=GS A0A8C4MV91_EQUAS/2445-2623  AC A0A8C4MV91.1
#=GS A0A3Q7RAH0_VULVU/2173-2325  AC A0A3Q7RAH0.1
#=GS A0A6P9BA83_PANGU/2576-2757  AC A0A6P9BA83.1
#=GS A0A485P3U2_LYNPA/1169-1340  AC A0A485P3U2.1
#=GS A0A091RJK7_9GRUI/1783-1962  AC A0A091RJK7.1
#=GS A0A820CDB9_9BILA/1025-1133  AC A0A820CDB9.1
#=GS A0A8B9MII0_9AVES/947-1119   AC A0A8B9MII0.1
#=GS A0A8B9YY05_BOSMU/974-1152   AC A0A8B9YY05.1
#=GS A0A8C2YBG4_COTJA/2058-2239  AC A0A8C2YBG4.1
#=GS G0R3C8_ICHMG/1950-2132      AC G0R3C8.1
#=GS A0A084WBG3_ANOSI/1855-2035  AC A0A084WBG3.1
#=GS A0A7N6BNC5_ANATE/2354-2532  AC A0A7N6BNC5.1
#=GS A0A7M7SY40_STRPU/1987-2167  AC A0A7M7SY40.1
#=GS A0D7A2_PARTE/1948-2115      AC A0D7A2.1
#=GS A0A670KAA2_PODMU/1027-1205  AC A0A670KAA2.1
#=GS G3TM79_LOXAF/2306-2482      AC G3TM79.1
#=GS A0A8C0U2E1_CYACU/2424-2605  AC A0A8C0U2E1.1
#=GS A0A8I6GMJ7_RAT/2537-2718    AC A0A8I6GMJ7.1
#=GS F6SEI8_HORSE/1937-2118      AC F6SEI8.3
#=GS A0A813B6A7_9DINO/1597-1779  AC A0A813B6A7.1
#=GS A0A218VD66_9PASE/1791-1972  AC A0A218VD66.1
#=GS A0A7K9XH13_9GRUI/1836-2015  AC A0A7K9XH13.1
#=GS A0A1R1XY96_9FUNG/2682-2864  AC A0A1R1XY96.1
#=GS A0A672ZVJ2_9TELE/994-1172   AC A0A672ZVJ2.1
#=GS A0A669D0H3_ORENI/2094-2275  AC A0A669D0H3.1
#=GS A0A674DLK3_SALTR/2420-2601  AC A0A674DLK3.1
#=GS A0A3Q1JPI4_ANATE/2547-2730  AC A0A3Q1JPI4.2
#=GS A0A8R2QWI5_BOMMO/2601-2782  AC A0A8R2QWI5.1
#=GS A0A2I1FWF3_9GLOM/2594-2776  AC A0A2I1FWF3.1
#=GS A0A803SUF8_ANOCA/1941-2121  AC A0A803SUF8.1
#=GS A0A8B6E2C3_MYTGA/2046-2227  AC A0A8B6E2C3.1
#=GS A0A4V6RG13_9HYME/1769-1948  AC A0A4V6RG13.1
#=GS A0A8C3CT99_CAIMO/2184-2363  AC A0A8C3CT99.1
#=GS A0A812P3N5_9DINO/2734-2851  AC A0A812P3N5.1
#=GS A0A6J3K8V1_9HYME/1615-1796  AC A0A6J3K8V1.1
#=GS A0A5B8MFR9_9CHLO/1968-2149  AC A0A5B8MFR9.1
#=GS A0A7K8HM30_9CORV/2456-2635  AC A0A7K8HM30.1
#=GS B4N8N4_DROWI/2485-2666      AC B4N8N4.2
#=GS V5BTQ6_TRYCR/2315-2496      AC V5BTQ6.1
#=GS A0A078ATU8_STYLE/2141-2324  AC A0A078ATU8.1
#=GS A0A669KB38_HUMAN/2534-2715  AC A0A669KB38.1
#=GS A0A8C9EAK5_PHOSS/1866-2045  AC A0A8C9EAK5.1
#=GS A0A834XY04_9HYME/2556-2738  AC A0A834XY04.1
#=GS A0A674EYZ7_SALTR/2229-2408  AC A0A674EYZ7.1
#=GS W4GMI7_APHAT/2077-2257      AC W4GMI7.1
#=GS A0A8K0C7V2_9COLE/2048-2229  AC A0A8K0C7V2.1
#=GS A0A665WAK2_ECHNA/2553-2735  AC A0A665WAK2.1
#=GS A0A8C4GZ17_DICLA/2417-2596  AC A0A8C4GZ17.2
#=GS A0A2P6V138_9CHLO/2859-3036  AC A0A2P6V138.1
#=GS A0A091D0M6_FUKDA/2257-2433  AC A0A091D0M6.1
#=GS A0A8J4BRA9_9CHLO/2101-2280  AC A0A8J4BRA9.1
#=GS A0A183N3I6_9TREM/1-84       AC A0A183N3I6.1
#=GS J9IV20_9SPIT/2124-2306      AC J9IV20.1
#=GS K7FFX2_PELSI/2408-2587      AC K7FFX2.1
#=GS A0A1A6FYJ6_NEOLE/2-81       AC A0A1A6FYJ6.1
#=GS A0A8B8EH87_CRAVI/2592-2773  AC A0A8B8EH87.1
#=GS A0A7N8WKA4_9TELE/2249-2423  AC A0A7N8WKA4.1
#=GS A0A0L0VXP2_9BASI/2700-2882  AC A0A0L0VXP2.1
#=GS A0A183JY70_9TREM/351-525    AC A0A183JY70.1
#=GS Q4Q8K9_LEIMA/2144-2326      AC Q4Q8K9.1
#=GS A0A6A4WGE3_AMPAM/2073-2252  AC A0A6A4WGE3.1
#=GS A0A2T7NDA7_POMCA/2371-2528  AC A0A2T7NDA7.1
#=GS A0A6J0UBG6_9SAUR/1169-1349  AC A0A6J0UBG6.1
#=GS A0A8C9BSH8_PHOSS/2419-2597  AC A0A8C9BSH8.1
#=GS A0A1S3Q6X8_SALSA/2414-2593  AC A0A1S3Q6X8.1
#=GS A0A8C4YHT6_9SAUR/2216-2394  AC A0A8C4YHT6.1
#=GS A0A8D2E1W6_SCIVU/1987-2167  AC A0A8D2E1W6.1
#=GS A0A0G4FEQ2_VITBC/2435-2634  AC A0A0G4FEQ2.1
#=GS A0A835SS83_CHLIN/2220-2400  AC A0A835SS83.1
#=GS A0A812URX5_9DINO/2485-2676  AC A0A812URX5.1
#=GS A0A6I8NFW7_ORNAN/2087-2268  AC A0A6I8NFW7.1
#=GS A0A8C8JNA7_ONCTS/1122-1302  AC A0A8C8JNA7.1
#=GS A0A8C5JBP5_JUNHY/2303-2484  AC A0A8C5JBP5.1
#=GS A0A4W5QVG2_9TELE/988-1168   AC A0A4W5QVG2.1
#=GS A0A8C0ZJK5_CYACU/980-1159   AC A0A8C0ZJK5.1
#=GS A0A074ZTG9_9TREM/2652-2815  AC A0A074ZTG9.1
#=GS A0A813PVH2_9BILA/926-1107   AC A0A813PVH2.1
#=GS A0A8C3GE33_CAIMO/1936-2117  AC A0A8C3GE33.1
#=GS A0A7K8SI26_9AVES/1244-1425  AC A0A7K8SI26.1
#=GS A0A8J2WB14_9NEOP/799-979    AC A0A8J2WB14.1
#=GS A0A6Q2ZF27_ESOLU/1743-1923  AC A0A6Q2ZF27.1
#=GS A0A3L8S0W4_CHLGU/2504-2683  AC A0A3L8S0W4.1
#=GS A0A8D2B7B8_SCIVU/2439-2618  AC A0A8D2B7B8.1
#=GS G4YYI9_PHYSP/2439-2622      AC G4YYI9.1
#=GS G1SRN0_RABIT/1937-2118      AC G1SRN0.3
#=GS A0A6P6R3T4_CARAU/2468-2646  AC A0A6P6R3T4.1
#=GS A0A7L0T9K7_PODPO/2270-2441  AC A0A7L0T9K7.1
#=GS A0A482WFR9_LAOST/2570-2751  AC A0A482WFR9.1
#=GS A0A8D2FP52_THEGE/2020-2200  AC A0A8D2FP52.1
#=GS A0A8B9MGM6_9AVES/1001-1164  AC A0A8B9MGM6.1
#=GS A0A8C5ZAN0_MARMA/1981-2162  AC A0A8C5ZAN0.1
#=GS U3IQD1_ANAPP/367-548        AC U3IQD1.2
#=GS A0A7N4P678_SARHA/2332-2510  AC A0A7N4P678.1
#=GS A0A024GEF2_9STRA/2149-2329  AC A0A024GEF2.1
#=GS A0A6A0AI60_HAELA/92-195     AC A0A6A0AI60.1
#=GS A0A836JKY3_9HYME/2276-2456  AC A0A836JKY3.1
#=GS A0A5J5DL66_9PERO/2207-2379  AC A0A5J5DL66.1
#=GS A0A8C4BHH4_9TELE/1847-2027  AC A0A8C4BHH4.1
#=GS A0A8C3CVI2_CAIMO/1080-1261  AC A0A8C3CVI2.1
#=GS A0A3M6TE02_POCDA/2521-2704  AC A0A3M6TE02.1
#=GS A0A835VNY6_CHLIN/2397-2579  AC A0A835VNY6.1
#=GS A0A8C5BDW9_GADMO/2424-2602  AC A0A8C5BDW9.1
#=GS K9G0H0_PEND2/2557-2739      AC K9G0H0.1
#=GS A0A803K7B6_XENTR/2829-3011  AC A0A803K7B6.1
#=GS A0A7M4FZ87_CROPO/2565-2747  AC A0A7M4FZ87.1
#=GS A0A4W5QL62_9TELE/406-469    AC A0A4W5QL62.1
#=GS A0A210QEQ1_MIZYE/2554-2736  AC A0A210QEQ1.1
#=GS A0A427XX17_9TREE/2550-2732  AC A0A427XX17.1
#=GS A0A2A4JUQ2_HELVI/1-69       AC A0A2A4JUQ2.1
#=GS A0A6J2N5X7_9CHIR/1988-2168  AC A0A6J2N5X7.1
#=GS A0A6P5DL97_BOSIN/2556-2738  AC A0A6P5DL97.1
#=GS A0A7J7WKS1_PIPKU/2468-2646  AC A0A7J7WKS1.1
#=GS A0DQI4_PARTE/1644-1837      AC A0DQI4.1
#=GS A0A7L4FHI6_9COLU/2264-2434  AC A0A7L4FHI6.1
#=GS A0A482XSW1_LAOST/1-89       AC A0A482XSW1.1
#=GS A0A811JSR1_9BILA/2540-2722  AC A0A811JSR1.1
#=GS A0A6P9APM8_PANGU/120-191    AC A0A6P9APM8.1
#=GS A0A0M4EBX0_DROBS/2101-2273  AC A0A0M4EBX0.1
#=GS A0A672TTU8_STRHB/1027-1205  AC A0A672TTU8.1
#=GS A0A8C4VEP1_FALTI/861-1040   AC A0A8C4VEP1.1
#=GS A0A7M7QBQ6_NASVI/1856-2037  AC A0A7M7QBQ6.1
#=GS A0A814ZDD5_ADIRI/2457-2635  AC A0A814ZDD5.1
#=GS A0A8J2B0L0_9DINO/1405-1586  AC A0A8J2B0L0.1
#=GS A0A8J6F2U1_ELECQ/2092-2273  AC A0A8J6F2U1.1
#=GS A0A8C7LTV9_ONCKI/2108-2289  AC A0A8C7LTV9.1
#=GS J9HQL8_9SPIT/2643-2824      AC J9HQL8.1
#=GS A0A5A8CU68_CAFRO/2584-2764  AC A0A5A8CU68.1
#=GS A0A834XQK7_9HYME/2167-2300  AC A0A834XQK7.1
#=GS A0A813FWE5_POLGL/2281-2461  AC A0A813FWE5.1
#=GS A0A024FXN1_9STRA/2021-2204  AC A0A024FXN1.1
#=GS A0A7N8YL38_9TELE/1017-1194  AC A0A7N8YL38.1
#=GS A0A0L7K4N5_PLAFX/3522-3644  AC A0A0L7K4N5.1
#=GS A0A814PAQ2_9BILA/2592-2773  AC A0A814PAQ2.1
#=GS A0A0B4KHJ4_DROME/2448-2626  AC A0A0B4KHJ4.1
#=GS A0A0Q9X1G6_DROWI/2557-2739  AC A0A0Q9X1G6.1
#=GS A0A1S8W9Y7_9FUNG/2237-2408  AC A0A1S8W9Y7.1
#=GS A0A4W4FY97_ELEEL/2169-2347  AC A0A4W4FY97.1
#=GS A0A8D2J0J4_VARKO/2528-2709  AC A0A8D2J0J4.1
#=GS A0A7K6XR29_9PASE/2260-2431  AC A0A7K6XR29.1
#=GS A0A3Q3F240_KRYMA/2183-2353  AC A0A3Q3F240.1
#=GS A0A803TQQ8_ANOCA/1069-1177  AC A0A803TQQ8.1
#=GS A0A452GIW8_9SAUR/2171-2349  AC A0A452GIW8.1
#=GS A0A2Y9QXS1_TRIMA/2381-2561  AC A0A2Y9QXS1.1
#=GS A0A8C4NSC2_DICLA/1109-1289  AC A0A8C4NSC2.2
#=GS A0A1J4L362_9EUKA/2034-2213  AC A0A1J4L362.1
#=GS A0A1Y2BFI1_9FUNG/2283-2465  AC A0A1Y2BFI1.1
#=GS A0A8K0C4P9_9COLE/819-1000   AC A0A8K0C4P9.1
#=GS D2A3H9_TRICA/306-487        AC D2A3H9.1
#=GS A0A7N6BK52_ANATE/2208-2394  AC A0A7N6BK52.1
#=GS A0A1J1HNC4_9DIPT/2218-2396  AC A0A1J1HNC4.1
#=GS A0A2U3X1U0_ODORO/2261-2433  AC A0A2U3X1U0.1
#=GS A0A2K5ISM5_COLAP/2372-2527  AC A0A2K5ISM5.1
#=GS A0A1R2C1A6_9CILI/1902-2082  AC A0A1R2C1A6.1
#=GS A0A7K9JQ35_9PASE/2443-2622  AC A0A7K9JQ35.1
#=GS G1SYW3_RABIT/2341-2522      AC G1SYW3.2
#=GS A0A7I8W8D1_9ANNE/2890-2993  AC A0A7I8W8D1.1
#=GS A0A8B9Q703_APTOW/1022-1178  AC A0A8B9Q703.1
#=GS A0A8B7DNX3_HYDVU/598-778    AC A0A8B7DNX3.1
#=GS A0A0P1B063_PLAHL/2564-2745  AC A0A0P1B063.1
#=GS A0A4W2BTJ8_BOBOX/1989-2169  AC A0A4W2BTJ8.1
#=GS A0A3P7QNW0_DIBLA/1-30       AC A0A3P7QNW0.1
#=GS F7CJM1_XENTR/1905-2086      AC F7CJM1.4
#=GS A0A3Q2KVK0_HORSE/2262-2433  AC A0A3Q2KVK0.1
#=GS A0A482WUY6_LAOST/2546-2727  AC A0A482WUY6.1
#=GS A0A803TFH7_ANOCA/2010-2189  AC A0A803TFH7.1
#=GS A0A0C4F2H1_PUCT1/37-219     AC A0A0C4F2H1.1
#=GS D0NKV6_PHYIT/2462-2640      AC D0NKV6.1
#=GS A0A3S5AJ19_9PLAT/1-134      AC A0A3S5AJ19.1
#=GS A0A668A8S8_9TELE/2182-2360  AC A0A668A8S8.1
#=GS A0A7J6JE24_COLFN/2562-2744  AC A0A7J6JE24.1
#=GS A0A8C5F9V4_GADMO/1024-1202  AC A0A8C5F9V4.1
#=GS A0A7J7KPV1_BUGNE/464-644    AC A0A7J7KPV1.1
#=GS A0A7K8M5S1_9CORV/1232-1413  AC A0A7K8M5S1.1
#=GS A0A7K6XEG9_9PASE/1943-2123  AC A0A7K6XEG9.1
#=GS A0A2V0NY01_9CHLO/1-104      AC A0A2V0NY01.1
#=GS A0A8C8S9X7_9SAUR/2556-2738  AC A0A8C8S9X7.1
#=GS A0A3R7KAL3_TRYRA/2079-2261  AC A0A3R7KAL3.1
#=GS A0A0Q3USZ4_AMAAE/2414-2593  AC A0A0Q3USZ4.1
#=GS A0A6J0WFL6_ODOVR/1645-1705  AC A0A6J0WFL6.1
#=GS F7F837_MONDO/2239-2413      AC F7F837.3
#=GS A0A8B7YSY5_ACAPL/2623-2804  AC A0A8B7YSY5.1
#=GS A0A851Z6E8_9AVES/2436-2617  AC A0A851Z6E8.1
#=GS A0A7M4G0C2_CROPO/2258-2430  AC A0A7M4G0C2.1
#=GS R7UMY7_CAPTE/2335-2516      AC R7UMY7.1
#=GS A0A5F5XZT5_FELCA/1117-1294  AC A0A5F5XZT5.1
#=GS A0A4U5U6I0_COLLU/1847-2028  AC A0A4U5U6I0.1
#=GS A0A8C3GNK0_CAIMO/2534-2715  AC A0A8C3GNK0.1
#=GS A0A3P8VG82_CYNSE/1890-2070  AC A0A3P8VG82.1
#=GS A0A0C4DP44_MAGP6/2552-2734  AC A0A0C4DP44.1
#=GS E4XZZ6_OIKDI/614-795        AC E4XZZ6.1
#=GS A0A6A4FL52_9STRA/2097-2224  AC A0A6A4FL52.1
#=GS A1CBD0_ASPCL/2555-2737      AC A1CBD0.1
#=GS A0A668UJH6_OREAU/1234-1400  AC A0A668UJH6.1
#=GS H0VLU3_CAVPO/2319-2491      AC H0VLU3.2
#=GS I3JBA9_ORENI/2553-2735      AC I3JBA9.2
#=GS A0A7J8GXW8_ROUAE/2365-2536  AC A0A7J8GXW8.1
#=GS A0A2J8KP88_PANTR/2377-2557  AC A0A2J8KP88.1
#=GS A0A6I8NYC7_ORNAN/2121-2299  AC A0A6I8NYC7.1
#=GS A0A3P6WPU0_HYMDI/2147-2325  AC A0A3P6WPU0.1
#=GS A0A850V8S2_9CORV/2482-2661  AC A0A850V8S2.1
#=GS A0A8W8JGB8_CRAGI/2958-3144  AC A0A8W8JGB8.1
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#=GS A0A8B9IQ65_ANSCY/1008-1189  AC A0A8B9IQ65.1
#=GS L1JJK8_GUITC/2469-2647      AC L1JJK8.1
#=GS A0A654H1P0_9CEST/2165-2337  AC A0A654H1P0.1
#=GS A0A0L0C377_LUCCU/1905-2046  AC A0A0L0C377.1
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