#=GF ID AAA_lid_PRS2_C
#=GF AC PF23902.1
#=GF DE PRS2 AAA+ lid C-terminal domain
#=GF AU Barrionuevo E;0000-0003-3271-6305
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE AlphaFold prediction
#=GF GA 34.00 34.00;
#=GF TC 34.00 34.30;
#=GF NC 33.90 33.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0671
#=GF RN [1]
#=GF RM 20427185
#=GF RT Assembly, structure, and function of the 26S proteasome.
#=GF RA Bedford L, Paine S, Sheppard PW, Mayer RJ, Roelofs J;
#=GF RL Trends Cell Biol. 2010;20:391-401.
#=GF DR INTERPRO; IPR057408;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the C-terminal AAA+ lid domain of
#=GF CC bacterial Putative 26S proteasome regulatory subunit homologues
#=GF CC (PRS2). This alpha-helical bundle is found in association with a
#=GF CC core AAA-ATPase domain (Pfam:PF00004). The 26S proteasome is a
#=GF CC large multiprotein complex involved in the regulated degradation
#=GF CC of ubiquitinated proteins. This complex can be divided in two
#=GF CC sub-complexes, the core particle (CP, 20S) and the regulatory
#=GF CC particle (RP, 19S). The RP consists of 19 subunits organised in
#=GF CC two sub-structures, the base and lid complexes. The base
#=GF CC consists of a ring of six AAA-ATPases. The C-termini of these
#=GF CC ATPases dock into pockets present between the alpha-subunits of
#=GF CC the CP, mediating the protein complex interactions [1].
#=GF SQ 48
#=GS F2KR94_ARCVS/273-347 AC F2KR94.1
#=GS A0A366MAR7_9EURY/291-360 AC A0A366MAR7.1
#=GS A0AA51UG48_9EURY/290-363 AC A0AA51UG48.1
#=GS A0A328SCQ4_9EURY/288-360 AC A0A328SCQ4.1
#=GS A0A8T8K5F0_9EURY/292-364 AC A0A8T8K5F0.1
#=GS PRS2_METTH/292-364 AC O27092.1
#=GS A0A0F7IFM5_9EURY/270-342 AC A0A0F7IFM5.1
#=GS F0T723_METLA/291-364 AC F0T723.1
#=GS A0A964DBB7_9EURY/286-359 AC A0A964DBB7.1
#=GS A0A0U3EM97_9EURY/296-367 AC A0A0U3EM97.1
#=GS A0A1V6N239_METAZ/293-363 AC A0A1V6N239.1
#=GS L0KW92_METHD/283-357 AC L0KW92.1
#=GS D7DVA4_METV3/290-362 AC D7DVA4.1
#=GS Q6M193_METMP/291-363 AC Q6M193.1
#=GS A0A166BVF9_9EURY/305-376 AC A0A166BVF9.1
#=GS Q8TLK7_METAC/288-360 AC Q8TLK7.1
#=GS A0A328PI13_9EURY/292-363 AC A0A328PI13.1
#=GS D5E9H6_METMS/287-358 AC D5E9H6.1
#=GS O28983_ARCFU/270-341 AC O28983.1
#=GS A0A1D3KZH0_9EURY/292-364 AC A0A1D3KZH0.1
#=GS A0B714_METTP/303-375 AC A0B714.1
#=GS A0A484F6G7_9EURY/291-365 AC A0A484F6G7.1
#=GS A0A1D2WCH4_9EURY/292-364 AC A0A1D2WCH4.1
#=GS A0A2U1S709_9EURY/293-367 AC A0A2U1S709.1
#=GS A0A126R1G5_METOL/294-365 AC A0A126R1G5.1
#=GS A0A166CPK9_9EURY/294-365 AC A0A166CPK9.1
#=GS F6BAK2_METIK/289-361 AC F6BAK2.1
#=GS U6E9V2_9EURY/292-364 AC U6E9V2.1
#=GS PRS2_METJA/289-361 AC Q58889.2
#=GS A0A5B9DAY7_9ARCH/305-377 AC A0A5B9DAY7.1
#=GS A0A328SIL8_9EURY/290-362 AC A0A328SIL8.1
#=GS F4BYP9_METSG/284-355 AC F4BYP9.1
#=GS E3GXP9_METFV/291-363 AC E3GXP9.1
#=GS A0A0E3SP66_METMT/247-321 AC A0A0E3SP66.1
#=GS A0AA43UH28_9EURY/290-362 AC A0AA43UH28.1
#=GS A0A4E0QQV9_9EURY/291-364 AC A0A4E0QQV9.1
#=GS A0A916LUT1_9FLAO/286-354 AC A0A916LUT1.1
#=GS R9SMG7_9EURY/293-365 AC R9SMG7.1
#=GS G7WMZ0_METH6/284-356 AC G7WMZ0.1
#=GS N0BJ83_9EURY/272-343 AC N0BJ83.1
#=GS D2RHN9_ARCPA/267-341 AC D2RHN9.1
#=GS A0A328RZR0_9EURY/281-353 AC A0A328RZR0.1
#=GS A0A166A4A6_9EURY/329-399 AC A0A166A4A6.1
#=GS A0AAE4MJC6_9EURY/292-364 AC A0AAE4MJC6.1
#=GS F7XNG6_METZD/285-359 AC F7XNG6.1
#=GS A0A0E3NXS8_9EURY/281-354 AC A0A0E3NXS8.1
#=GS Q8TVM1_METKA/256-325 AC Q8TVM1.1
#=GS Q2NEG7_METST/289-361 AC Q2NEG7.1
F2KR94_ARCVS/273-347 ...........y-EERLEILRKNLQEFP..LE.V..K.A..KLDEVARQTEGFSGRDLVEKVIKSALHRAIAEGRDRIETEDFMKAAVK----tmpvkn........
A0A366MAR7_9EURY/291-360 ...........t--ERISMIEKFIDNMP..FN.V..Q.V..SSKKLAEMSKGMSGRDIKEKLLKSALHRTLYEDKEIIDLNHFEHAL------ntyk..........
A0AA51UG48_9EURY/290-363 ..........de-KERLEILESNIETFP..IP.A..KgV..DLKAIAKMTGGLSGRDLVGKVLKTALHNVIIEDREFVSAEDLLASVKKL---kn............
A0A328SCQ4_9EURY/288-360 ...........e-EERRKLLETNIKTMP..LE.C..N.F..SMDVLVTKTKGFSGRDLKEKILKTAMHKAISESEDIITDRHIEYAIKE----sske..........
A0A8T8K5F0_9EURY/292-364 ...........e-NERREMIEKYIESMP..LE.V..K.V..SRTKLAQSSKGMSGRDIKEKLLKTALHKAISEDKSTVDREDIEYALKN----yqte..........
PRS2_METTH/292-364 ............DEERKLMLEKYIETMP..LK.V..D.F..PVDKLVKLTREMSGRDIKDRVLKTALHRAIAEDSESVRAEHIEYALKE----rkvs..........
A0A0F7IFM5_9EURY/270-342 ...........s-EERYMILKKSLEDFP..LP.V..N.A..NLEEVARVTEGFSGRDLVEKVIKASLHKAIVEGRDVITTQDLLNSVQKVS--kp............
F0T723_METLA/291-364 ..........de-KDRKAILELYIETLP..LK.T..D.F..NIEKLVKCTKGMSGRDIKDRVLKVALHKAIFEDQEIITWGHCKYALKQ----hkik..........
A0A964DBB7_9EURY/286-359 ...........l-DERHEILKAYSRTFPrkLA.N..D.V..DLKAFSRQTQGFSGRDLVEKLLKNALHKAILAG-GKVTEKHFEQALSEA---igk...........
A0A0U3EM97_9EURY/296-367 ............DKDRYEIFKRNIETLP..ID.C..D.L..NIGKLVKLSKNMSGRDIKEKILKTALHHAIANDKDIVDMSDIDYAF------esski.........
A0A1V6N239_METAZ/293-363 ...........f-EERIIMIENFIETMP..FE.V..E.V..SSKKLAQMSKGMSGRDIKEKLLKSALHRALYDDKEKIELKHFEEGL------nsyk..........
L0KW92_METHD/283-357 ...........e-EERFRILEMNISTFP..LP.V..KdV..DVKKIATMTKGLSGRDLVEKVLKTALHQAIIEDNEEVTGKHFEESVGKLF--qkn...........
D7DVA4_METV3/290-362 ...........e-KERLEILKTYSKKLP..IK.T..N.V..DFKKYVKKTEGMNGRTLKEKLLKPLLHKAIIEELTEISEKDFEETLNRLI--nq............
Q6M193_METMP/291-363 ............DNERLKILELYAEKMP..IA.V..N.A..DLKKYVEKTKGMNGRTIKEKFLKPALHKAILEDRESITQKDLDEIIKKIVKN..............
A0A166BVF9_9EURY/305-376 ............ENERTAIFKKYMDTLP..IP.V..D.E..TPEKLAKLTKGFSGRDIKEKVLKSSLHMALSNDKNSISSKYISKAI------dgskk.........
Q8TLK7_METAC/288-360 ...........e-EEIIHILESNVKTFP..LQ.V.eK.Y..DFQALGKKAKGLSGRDIVEKILKTALHQAIIDDRESVTGKDFEKAFAKL---gr............
A0A328PI13_9EURY/292-363 ...........e-DERREMIKRYMETMP..LK.I..E.Y..PIEKLVKLTKGMSGRDIKEKILKNALHQAIAEDSDTITEKHIEKIFR-----dnnk..........
D5E9H6_METMS/287-358 ...........k-EERKEIIKLNLQTFP..IK.A..E.A..NVDELAKLTNGLSGRDIVEKILKSALHNAIMDDMEKVEAHYFEK--------aasglqk.......
O28983_ARCFU/270-341 ...........y-EERLEILRRNLEEFP..VP.V..K.A..RLELVAAASEGFSGRDLVEKVIKASLHKAIAEGKDKIETEDLLTAAEKV---km............
A0A1D3KZH0_9EURY/292-364 ............ENERKEILELYIKSMP..LP.V..E.A..DIKKLTAASKGMSGRDIKDKLLKVALHKAISEDRETVTWDDVEYSLKQ----hkke..........
A0B714_METTP/303-375 ...........h-EDRLEILRRNASKMP..LE.V..R.G..DLAEIAKLTEGFSGRDLVDKILKVALHQAIIEDSRFVERRHLMDALQRI---krd...........
A0A484F6G7_9EURY/291-365 ........adev----EQILQTNLETFP..LP.V..D.PtfSVKRFAKEATGFSGRDLVHKVLKTALHRAIIEDEKYVKTEYFTNALGELKK-n.............
A0A1D2WCH4_9EURY/292-364 ...........k-DQRQSMLENYIKTMP..VE.M..K.V..DIKRLANISKGMSGRDIKERLLKTALHKAISEDTDFVTWDHVEYAL------nlykte........
A0A2U1S709_9EURY/293-367 ...........e-EERRLIFENNLKTYP..LK.T..D.L..NIEKLVKLTKNMSGRDIKEKILKTALHHSISQDKEIVTMNDIDYALKS----tkikin........
A0A126R1G5_METOL/294-365 ............DNERREIIKLNLNTFP..LK.Y..D.L..DIDKLVKISKRMSGRDIKEKILKTALHNAIINDKEIVTMEDIYFAL------dinky.........
A0A166CPK9_9EURY/294-365 ...........e-KERIAILDKYIKTLP..LT.V..E.P..TSKKLAKLTKGMSGRDLKEKILKSSLHNAISNDDDVISMEHINLALNK----sks...........
F6BAK2_METIK/289-361 ............DKERLKIMELYAKKMP..IP.I..K.A..DLRKYVEKTKGMSGRDIKEKFLKPALHKAILEDRDYISKEDLDAALKKILG-d.............
U6E9V2_9EURY/292-364 ...........e-DERKKILEMYIKSMP..LP.V..D.V..NIKKLAKLSKGMSGRDIKDRLLKVALHKAISEDQESVTWENFQYALKH----qeke..........
PRS2_METJA/289-361 ............DEERLKIMELYAKKMP..LP.V..K.A..NLKEFVEKTKGFSGRDIKEKFLKPALHRAILEDRDYVSKEDLEWALKKILGN..............
A0A5B9DAY7_9ARCH/305-377 ...........v-EERVDLLKLFSKKIP..FE.I..E.I..DFKIIAKNTENWSGRALHEKLIKIAVHKAIQQDLKIVTTDMLMEIINQ----gknn..........
A0A328SIL8_9EURY/290-362 ............DRDRLEILENNMKTLP..LE.C..V.F..NVDAFVEKTKGFSGRDIKQKVLKTALHKAITESKEFINDEDIDYAIE-----eskke.........
F4BYP9_METSG/284-355 ...........k-DERLQILEKNASTLP..LEmV..D.V..DLKEIARQTDGFSGRDLVEKVLKVALHHALMD-ECNISQKHIEEALP-----rark..........
E3GXP9_METFV/291-363 ...........k-EERKEMIKRHIKTMP..LP.V..T.V..SPNKLAELSKGMSGRDIKEKLLKTALHKAIVDNDKKIENKHIKYALE-----hykkk.........
A0A0E3SP66_METMT/247-321 ..........de-KDRHRIIEQNISTFP..LP.A..EdV..DLQKLAKLTAGLSGRDIVEKVLKNALHQAIVDDREEVGQELFENAISRLVK-k.............
A0AA43UH28_9EURY/290-362 ...........t-EDRREIIKKNLKTLP..LK.T..N.I..NLESLVTKTKNLSGRDIKEKIIKVALHQALIEEVCIITDKHLTYALNQF---nhn...........
A0A4E0QQV9_9EURY/291-364 ............ENERLAILESNIKTFP..IP.V..KdV..NLKVIAKMTKGLSGRDLVGKVLKTALHNVIIEDRENVTQDDLRTSVKKIMK-v.............
A0A916LUT1_9FLAO/286-354 ...........v-EERVEILKFYTATFPkkLA.K..D.V..DLEALAKLTPGFSGRDLVEKLLKNALHKAILK--------------------ggkvkmahfeaals
R9SMG7_9EURY/293-365 ...........l-NERKRILENNITSIP..IN.I..D.I..DIDKVAKMSKGMSGRDLKQKILKTALHHAIANDKTTIDMRDIEYAFKQ----skik..........
G7WMZ0_METH6/284-356 ...........a-EERLSILARNVETLP..VE.V..G.A.lDLAAISRLTEGFSGRDLVEKVLKVALHGAIIDE-VTIEQRHLEAAAAK----akke..........
N0BJ83_9EURY/272-343 ...........f-NERLEILRKNFKDFP..LK.V..K.A..NLEIVASNTEGFSGRDLVEKVIKPALHRAIADGKDYIETNDLITSIMR----vkk...........
D2RHN9_ARCPA/267-341 ...........l-EERLKILENNFRDFP..LK.V..R.A..NLKVIAEITEGFSGRDLVEKVIKSALHKAIAEEREYIGTEDLVKAVERV---kkpvk.........
A0A328RZR0_9EURY/281-353 ..........sg--DRLTILKKNMETLP..LE.C..V.F..DVDAFVEKTKGFSGRDIKEKVLKTALHKAISESRDMIDDEDINYAIS-----eshkd.........
A0A166A4A6_9EURY/329-399 ...........k-KERIAILDKYIETLP..IK.V..E.P..TSKLLAELTKGMSGRDIKEKILKSSLHHAISNDNEVISMEDIRNALKN----ak............
A0AAE4MJC6_9EURY/292-364 eieqilssnlat--------------FP..LP.VdpN.F..NIRKFAESAKGLSGRDLTDKILKTALHRAIIDDEKMVAASYFDDALTE----lkks..........
F7XNG6_METZD/285-359 ..........de-KERLEIIKKNIDTFP..LP.V.tD.I..DLSRIAKTTAGFSGRDIVEKLLKSALHLAIMDDKEYVTQEYFEKAISTIIK-d.............
A0A0E3NXS8_9EURY/281-354 ...........e-EEIRQIFESNVKTFP..LP.V..EdC..DFKALAKKAKGLSGRDLVEKVLKTALHQVIIEDRETVRAEDFEKAFSKLGKN..............
Q8TVM1_METKA/256-325 ..........kr--EREELVRYYAKKLP..MP.L..D.V..DPRYIAARTGGMSHREIKERVLKRALLEALREGAEKIERKHIQKVLN-----qe............
Q2NEG7_METST/289-361 ............DEERRIILEKNIKTLP..LK.C..S.F..NLDKLVCETKNLSGRDMKEKILKTALHRALCDSRDVINDEDVSYALDEIR--ke............
#=GC seq_cons .............cERhcILcp.lcThP..Lt.l..c.s..slcclAchTKGhSGRDlpEKlLKsALH+AIh-Dc-hlstcclctAlpp....pp............
//
