GenomeNet

Database: Pfam
Entry: APOBEC4
LinkDB: APOBEC4
Original site: APOBEC4 
#=GF ID   APOBEC4
#=GF AC   PF18775.4
#=GF DE   APOBEC4
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Iyer LM
#=GF GA   27.20 27.20;
#=GF TC   27.40 27.20;
#=GF NC   26.50 27.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0109
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF RN   [2]
#=GF RM   29555751
#=GF RT   Diversification of AID/APOBEC-like deaminases in metazoa:
#=GF RT   multiplicity of clades  and widespread roles in immunity.
#=GF RA   Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L;
#=GF RL   Proc Natl Acad Sci U S A. 2018;115:E3201.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A member of the AID/APOBEC family of cytosine deaminases. The
#=GF CC   biological function of APOBEC4 is poorly understood. However, it
#=GF CC   is widely conserved across vertebrates [1].
#=GF SQ   59
#=GS K7G211_PELSI/24-97        AC K7G211.1
#=GS F6SPN1_CIOIN/83-162       AC F6SPN1.2
#=GS A0A6F9ALQ4_9TELE/132-212  AC A0A6F9ALQ4.1
#=GS A0A091PTE0_LEPDC/1-75     AC A0A091PTE0.1
#=GS A0A091IKM1_CALAN/1-70     AC A0A091IKM1.1
#=GS A0A091G380_9AVES/22-106   AC A0A091G380.1
#=GS A0A091LC91_CATAU/22-106   AC A0A091LC91.1
#=GS A0A091QH63_MERNU/1-65     AC A0A091QH63.1
#=GS A0A091V9F4_NIPNI/1-65     AC A0A091V9F4.1
#=GS A0A091UXX9_PHALP/22-106   AC A0A091UXX9.1
#=GS A0A091GQ55_BUCRH/1-65     AC A0A091GQ55.1
#=GS A0A091UXU5_NIPNI/21-105   AC A0A091UXU5.1
#=GS A0A091TH63_PHALP/1-65     AC A0A091TH63.1
#=GS A0A091Q6M3_LEPDC/22-106   AC A0A091Q6M3.1
#=GS A0A087QVF4_APTFO/22-106   AC A0A087QVF4.1
#=GS A0A2P8Y320_BLAGE/1-70     AC A0A2P8Y320.1
#=GS A0A091KLV2_9GRUI/22-106   AC A0A091KLV2.1
#=GS A0A2T7P0M1_POMCA/76-175   AC A0A2T7P0M1.1
#=GS A0A093J6I5_FULGA/1-65     AC A0A093J6I5.1
#=GS A0A3M6T8U8_POCDA/75-160   AC A0A3M6T8U8.1
#=GS A0A091ETZ4_CORBR/1-64     AC A0A091ETZ4.1
#=GS A0A091MHU6_9PASS/1-63     AC A0A091MHU6.1
#=GS A0A5N4CNS0_CAMDR/22-106   AC A0A5N4CNS0.1
#=GS A0A099ZZR5_CHAVO/1-65     AC A0A099ZZR5.1
#=GS A0A087VRL2_BALRE/2-66     AC A0A087VRL2.1
#=GS A0A094LAG0_PODCR/1-65     AC A0A094LAG0.1
#=GS A0A091WDY6_OPIHO/1-75     AC A0A091WDY6.1
#=GS A0A091G853_9AVES/1-70     AC A0A091G853.1
#=GS A0A093CT04_TAUER/1-65     AC A0A093CT04.1
#=GS A0A093QYH8_PHACA/1-65     AC A0A093QYH8.1
#=GS A0A6J1U8W3_9SAUR/1-49     AC A0A6J1U8W3.1
#=GS A0A091R868_9GRUI/1-65     AC A0A091R868.1
#=GS A0A1S3T3Q2_SALSA/94-170   AC A0A1S3T3Q2.1
#=GS A0A4W5QAW3_9TELE/102-182  AC A0A4W5QAW3.1
#=GS A0A091PR75_HALAL/1-65     AC A0A091PR75.1
#=GS W5MW91_LEPOC/15-99        AC W5MW91.1
#=GS K7G211_PELSI/212-285      AC K7G211.1
#=GS A0A087QNJ4_APTFO/1-65     AC A0A087QNJ4.1
#=GS A0A2B4SME3_STYPI/91-177   AC A0A2B4SME3.1
#=GS A0A093HKT8_STRCA/22-106   AC A0A093HKT8.1
#=GS A0A099ZXL0_CHAVO/22-106   AC A0A099ZXL0.1
#=GS A0A099Z1L5_TINGU/22-106   AC A0A099Z1L5.1
#=GS A0A093ITV6_FULGA/22-106   AC A0A093ITV6.1
#=GS A0A093H7N8_GAVST/22-106   AC A0A093H7N8.1
#=GS A0A093R3S3_PYGAD/1-65     AC A0A093R3S3.1
#=GS A0A093NRV6_PYGAD/22-106   AC A0A093NRV6.1
#=GS A0A091RWG2_NESNO/1-65     AC A0A091RWG2.1
#=GS A0A6J2W7P4_CHACN/100-179  AC A0A6J2W7P4.1
#=GS A0A093I8Y9_STRCA/1-74     AC A0A093I8Y9.1
#=GS A0A662YLK0_ACIRT/104-188  AC A0A662YLK0.1
#=GS F6S0S9_CIOIN/277-366      AC F6S0S9.2
#=GS A0A091KXU3_COLST/22-106   AC A0A091KXU3.1
#=GS A0A093F6R6_GAVST/1-70     AC A0A093F6R6.1
#=GS A0A1U7S0S1_ALLSI/79-152   AC A0A1U7S0S1.1
#=GS A0A091V1W3_PHORB/1-65     AC A0A091V1W3.1
#=GS A0A093JP51_EURHL/1-65     AC A0A093JP51.1
#=GS A0A094K7N8_ANTCR/1-65     AC A0A094K7N8.1
#=GS A0A093DVS1_9AVES/22-85    AC A0A093DVS1.1
#=GS A0A091WIF8_OPIHO/22-106   AC A0A091WIF8.1
K7G211_PELSI/24-97                   ...................LTWYM..TWSP..CGE....CCKAIRDFL.......KEQP...NV.N.LV...IYVARIYCHE......................EENNRQGLRSLVNIG....VTIRIMDL.P.......VYSYCWRTFV..................................
F6SPN1_CIOIN/83-162                  ..................v-TVELmsSRSP..SNA....GAEQLQGFLe....ycKKHS..iKV.N.IN...FSFVQPFSWD......................NKFNREGLHNLYEKG....VKLKILSF.Q.......QVINCMMGD-l.................................
A0A6F9ALQ4_9TELE/132-212             ...................IMLYC..NYTP..CQE....CCQTMASFL.......LRYP...WM.R.LD...VLFSQLYHTAps.................qpySLDNQTGLRSLAALWp..rLTLSPISG.A.......AWGHLLRCFV..................................
A0A091PTE0_LEPDC/1-75                ...................VTWYL..SWSP..CVN....CCRKILNFL.......KKHS...NV.N.ID...MHVARLYYIE......................DERIRQGLKNLVSLA...kVTIAVMEI.E.......DYTYCWKNFI..................................
A0A091IKM1_CALAN/1-70                ...................ITWYL..SWSP..CAC....CCCKIQDFL.......KMNS...YV.N.TD...IDVAQLYGNY......................QEQNCQGLKNLKSLA...rVTIAVMRI.E.......DKISC-----..................................
A0A091G380_9AVES/22-106              ...................IILYS..SYSP..CNEvphcCVSKIYNFS.......LKYP...EI.T.LC...IYFSQLYHTQag.................cpsAAWNREALRSLWSLWp..rVTLQRPPG.E.......LWPSLLCPFV..................................
A0A091LC91_CATAU/22-106              ...................IILYS..NYSP..CNEayhcCVSKIYNFL.......LKYP...EI.T.LC...IYFSQLYHTEdg.................fptAAWNREALRSLSSLWp..rVTLQRLPG.G.......AWRYLLCNFV..................................
A0A091QH63_MERNU/1-65                ...................ITWYL..SWSP..CAN....CCYRIVQFL.......MKHS...YV.S.ID...IRVARLYFIE......................DETTRQGLEELVSCA...rVRLTVMDT.-.......----------e.................................
A0A091V9F4_NIPNI/1-65                ...................ITWYL..SRSP..CAK....CCYEILDFL.......NKHS...NV.N.ID...IYIAQLYKIK......................NEENCQGLRNLVSLA...kVTIAVMEI.-.......----------e.................................
A0A091UXX9_PHALP/22-106              ...................IILYS..NYSP..CNEahhfCISKIYNFL.......LKYP...EI.A.LC...IYFSQLYHTEdg.................fpsAAWNREALRSLSSLWp..rVTLQRLPG.G.......TWRYLLCNFV..................................
A0A091GQ55_BUCRH/1-65                ...................ITWYL..SWSP..CAD....CCCKIVNFL.......KKHS...YV.N.MR...IYVARLYYPE......................YETNRRGLKNLRNLA...eVPIAVMEI.-.......----------e.................................
A0A091UXU5_NIPNI/21-105              ...................IILYS..NYSP..CNEayhcCISKIYNFL.......LKYP...EI.T.LC...IYFSQLYHTEdg.................fptAAWNREALRSLSSLWp..rVTLQRLPG.G.......TWRYLLCNFV..................................
A0A091TH63_PHALP/1-65                ...................ITWYL..SWSP..CAD....CCHKILNFL.......KKHS...NV.N.II...IYVARLYYKE......................DEKIRQGLKNLVNLA...gITIAVMEI.-.......----------e.................................
A0A091Q6M3_LEPDC/22-106              ...................IILYS..NYSP..CNEayhcCISKIYNFL.......LKYQ...EI.I.LR...IYFSQLYHTEdc.................fptAAWNCRALWSLSSLWp..rVTLQRLPG.G.......AWHYLLCNFV..................................
A0A087QVF4_APTFO/22-106              ...................IILYS..TYSP..CNEayhcCISKIYNFL.......LKYP...EI.T.LC...IYFSQLYHTEdg.................sptAAWNREALRSLSSLWp..rVTLQRLPA.G.......AQRYLLCNFV..................................
A0A2P8Y320_BLAGE/1-70                ...................----M..SYSP..CGT....CTDAIIPFT.......EKRP...NC.N.VC...IAFSCLYRHK.....................kEEVHRDGLRQLNAEP...rISIKVFTK.I.......EWKTL-----aqa...............................
A0A091KLV2_9GRUI/22-106              ...................IILYS..NYSP..CNEahhcCVSKIYNFL.......LKYP...EI.R.LC...IYFSQLYHTEdg.................fptAVWNREALRSLSSLWp..rVILQRLPG.G.......MWHYLLCNFV..................................
A0A2T7P0M1_POMCA/76-175              .................ik--IYI..SFSP..CHQ....CSQKLIALLdh...akLNYN..iDL.K.VE...IVFAGLYRIFrpscisnftncvshlsrfpfkhNGKNVQGMMNLHSKG....VHLRTFDD.Q.......DWLDLLK---gl................................
A0A093J6I5_FULGA/1-65                ...................ITWYL..SWSP..CAK....CCRKILNFL.......KMHS...NV.K.ID...IYVARLYYIE......................DEKNRQGLKKLVSLA...gVKIAVMEI.-.......----------e.................................
A0A3M6T8U8_POCDA/75-160              ...........tgflhdlq--LLS..NFSP..CGE....CSEKICGWL.......AQND...SV.S.VS...IRFAHLHNIHvrv................qkvAEDNAIGLRKLVEKG....VQLKALSD.Y.......DWLQLLMI--dr................................
A0A091ETZ4_CORBR/1-64                ...................ITWYL..SWSP..CMT....CCYIIRNFL.......VRHP...NV.N.IE...IHVARLYNTR......................WAGTRRGLRELARLRg..rVTIDVM--.-.......----------e.................................
A0A091MHU6_9PASS/1-63                ...................ITWYL..SWSP..CVN....CCYKIRDFL.......NRHS...YV.T.IR...IYVARLCYRG......................FHRNRKGLRNLVSLR...eVTVNVM--.-.......----------e.................................
A0A5N4CNS0_CAMDR/22-106              ...................IILYS..NNSP..CDEanhcCTSKMYNFL.......TMYP...DV.T.LS...IYFSQLYHTEte.................fpaSAWNREALRSLASLWp..qVTVSPVSG.G.......VWHSLLNSFV..................................
A0A099ZZR5_CHAVO/1-65                ...................ITWYL..SWSP..CAE....CCLKILNFL.......EENS...NV.N.ID...IHIARLYRIQ......................DERNRQGLRELVSSE...eVTIAVMGI.-.......----------e.................................
A0A087VRL2_BALRE/2-66                ...................ITWYL..SWSP..CAD....CCHKILNFL.......KRHS...NV.N.ID...IYVARLYYIE......................DEEIRQCLKNLVSLA...eVTIAVMKI.E.......----------..................................
A0A094LAG0_PODCR/1-65                ...................ITWFL..SWSP..CAN....CCHKILNFL.......KKHS...NV.N.ID...IYVARLFHIE......................DEKNRQGLKNLVSLA...kVTIAVMET.-.......----------e.................................
A0A091WDY6_OPIHO/1-75                ...................ITWYL..SWSP..CAN....CCRKILNFL.......KKHS...YV.N.ID...IRVARLYYIQ......................VERNLQGLKKLESLA...nVTIGVMKI.K.......DYTDCWKIFI..................................
A0A091G853_9AVES/1-70                ...................ITWFL..SWSP..CAD....CCRKIMDFL.......MKHS...YV.N.ID...IRVARLYFIE......................DPKIRQGLKNLVSLA...gVNIAVMEI.K.......----------gkvfc.............................
A0A093CT04_TAUER/1-65                ...................ITWYL..SWSP..CAR....CCYKILDFL.......KEHS...YV.N.LH...IYVARLYCIE......................DEKTRRGLKKLNSLE...gVTIAVME-.-.......----------ee................................
A0A093QYH8_PHACA/1-65                ...................ITWYL..SWSP..CEE....CCCKILNFL.......KKHS...NV.S.IC...IYVARLYHIE......................DEKIRQGLKNLVNFT...kVTVAVMGI.-.......----------e.................................
A0A6J1U8W3_9SAUR/1-49                .................my-----..----..---....---------.......----...--.-.--...----QLYHTEed.................fpmSTWNCEALRSLASMWp..qVTLNPLCG.G.......LWHSLLYNFV..................................
A0A091R868_9GRUI/1-65                ...................ITWYL..SWSP..CAN....CCYEIVDFL.......QRHS...YV.N.IK...IFVARLYYID......................RERNRQGLRDLMNSA...gVTIDVMDI.E.......----------..................................
A0A1S3T3Q2_SALSA/94-170              ..................e-VLYS..NYMP..CQE....CSQTLISFL.......LRYP...WV.R.LD...LLFSQLYHTAps.................qthSLDNQTGLRSLAV--....LTLSPNSG.A.......AWGHLLRCFV..................................
A0A4W5QAW3_9TELE/102-182             ...................IMLYC..NYTP..CQE....CSQTLISFL.......LHYP...WV.R.QD...LLFSQLYHTAps.................qthSLDNQTGLRSLAALWp..rLTLSPISG.A.......AWGHLLRCFV..................................
A0A091PR75_HALAL/1-65                ...................ITWYL..SWSP..CAD....CCHKILKFL.......KKHS...NV.N.ID...IHVARVYYAE......................DEKVRQGLKNLVSLA...kVTIAVMET.-.......----------k.................................
W5MW91_LEPOC/15-99                   ...................VTLYS..NYTP..CEEppgrCASALTHFL.......QAHP...AL.R.LD...LLFSQLYHTEdw.................hpyGSANRQALRALGALWp..rLTLSPISG.G.......WWLSLLRKFV..................................
K7G211_PELSI/212-285                 ...................VTWFL..SWSP..CWK....CSQSVVEFR.......KAYP...KV.N.LE...IYVARLFRHE......................EECNRQGLRDLVMNG....VTIRVMNL.S.......AYNYCWRTFV..................................
A0A087QNJ4_APTFO/1-65                ...................ITWYL..SWSP..CAD....CCRKILNFL.......KKNS...NV.N.ID...IYVARLYYTE......................DEKIRQGLQNLVSLA...eVTIAVMET.-.......----------e.................................
A0A2B4SME3_STYPI/91-177              .........ltgflhdfql---LS..NFSP..CGE....CSEKICEWL.......AQNE...SV.S.VS...IRFAHLHNIHvrv................qkvAEDNAIGLRKLVEKG....VQLKALSD.Y.......DWLQLLMI--dr................................
A0A093HKT8_STRCA/22-106              ...................IILYS..NYSP..CNEadhcCISKIYNFL.......IKHP...EV.T.LC...IYFSQLYHTEds.................fptAMWNREALRSLSSLWp..hVTLYPLSG.G.......IRHYLLCNFV..................................
A0A099ZXL0_CHAVO/22-106              ...................IIVYS..NYSP..CNEayhcCVSKIYNFL.......LRYP...EI.T.LC...IYFSKLYHTEdr.................fptSVWNREALRSLSSLWp..qVTLQRLPG.G.......AWHYLLCNFV..................................
A0A099Z1L5_TINGU/22-106              ...................IILYS..NYSP..CNEadhcCLSKIYSFL.......TKYP...QV.T.LC...IYFSKLYHIEns.................lptAVWNHEVLKSLSSLWp..hVTLHPLCG.G.......IWHYLLCNFV..................................
A0A093ITV6_FULGA/22-106              ...................IILYS..NYSP..CNEayhyCISKIYNFL.......LKYP...EI.T.LC...IYFSQFYHTEdg.................fptAAWNREALRSLSSLWp..rVTLQRLPG.G.......ARRYLLRNFV..................................
A0A093H7N8_GAVST/22-106              ...................IILYA..NYSP..CNEayhcCVSKIYNFL.......LKYP...EI.T.LC...IYFSRLYHTEdh.................fptAVWNREALRSLSSLWp..rVTLQRLPG.G.......ARQYLLCNFV..................................
A0A093R3S3_PYGAD/1-65                ...................ITWYL..SWSP..CAD....CCRKILNFL.......KKNS...NV.N.ID...IYVARLYYIE......................DEKIRQGLQNLVSLA...eVTIAVMET.-.......----------e.................................
A0A093NRV6_PYGAD/22-106              ...................IILYS..NYSP..CNEayhcCISKIYNFL.......LKYP...EI.T.LC...IYFAQLYHTEdg.................fptAAWNREALRSLSSLWp..rVTLQRLPA.G.......AQRYLLCNFV..................................
A0A091RWG2_NESNO/1-65                ...................ITWYL..SWSP..CVN....CCRKILKFL.......KQHS...YV.N.IK...IYVARLYYID......................DDEIRQNLKNLVSLV...dVTIAVMDI.E.......----------..................................
A0A6J2W7P4_CHACN/100-179             ...................ILLYS..NYTP..CMEppnwCVDSVLNFL.......ERHP...WI.R.LD...LFFSQLHNPQ......................NPQNQAGLRSLASLWp..rVTLSPLSG.N.......AWGALIRRFV..................................
A0A093I8Y9_STRCA/1-74                ...................ITLYL..SWSP..CRN....CCYEMQYFL.......KKHP...NV.N.IC...IYLARLYYTE......................DEEICKALKDLSEKK....VIISVMKI.E.......DYIYCWKTFV..................................
A0A662YLK0_ACIRT/104-188             ...................VTLYC..SHTP..CNEpgsaCLSDTAGFL.......EDFP...GT.R.LD...LYFSQLYHTDer.................hpaSGWNREGLRALAGLWp..rVTLSPLSG.G.......GWLSLLRKFV..................................
F6S0S9_CIOIN/277-366                 ...............vdiv----M..SSSP..IHQ....CSETLLNLVqlektflKHRNfdgQL.N.VT...IRFAHSYGWDvkd................dviRERVHTGLRNLFKEG....VNLEIMSA.D.......IILDEL----rvdd..............................
A0A091KXU3_COLST/22-106              ...................IILFS..NYSP..CNEayhcCVSKIYNFL.......LKYP...EI.T.LC...IYFSQLYHIQdr.................sphAWWNREALRSLSSLWp..rVTLQRLPG.G.......AWPYLLCHFV..................................
A0A093F6R6_GAVST/1-70                ...................ITWYL..SWSP..CAN....CCRKILRFL.......RKHS...NV.N.ID...IHVARLYYIE......................DENIRQGLKSLVNLA...eVTIAVMEI.E.......----------gkvfc.............................
A0A1U7S0S1_ALLSI/79-152              ...................VTWYL..SWSP..CAD....CASKIVKFL.......KKYP...YL.K.LT...IYVAQLYYHT......................EEENRKGLRLLRSKK....VIIRVMDI.A.......DYNYCWKVFV..................................
A0A091V1W3_PHORB/1-65                ...................ITWYL..SWSP..CAK....CCYEILNFL.......KKHP...NV.N.ID...IYVARLYDIE......................KEKTRQGLKNLVRLP...eVTIAVMEM.-.......----------e.................................
A0A093JP51_EURHL/1-65                ...................ITWYL..SWSP..CAH....CCRKILNFL.......KRHS...DV.N.IH...IYIARLYYIE......................NEEIRQGLKNLVSLE...aVKIAVMET.-.......----------e.................................
A0A094K7N8_ANTCR/1-65                ...................ITWYL..SWSP..CAN....CCRKIRNFL.......KKHS...YV.Y.ID...IYVARLYYID......................DEENRRGLRNLQSLD...eVTIAVMEI.-.......----------e.................................
A0A093DVS1_9AVES/22-85               ...................IILYS..NFLP..CNEayhcCISNIYNFL.......LKYP...EI.T.LC...IYFSQLYHTQdt.................fcaTTWNRKALQSFS---....--------.-.......----------sen...............................
A0A091WIF8_OPIHO/22-106              ...................IILYA..NYSP..CNEayhcCISKIYNFL.......LKYP...EI.T.LC...IYFSRLYHTEdg.................fptATWNQEALRSLSSLWp..rVTLQRLPA.G.......TQHYLLLNFV..................................
#=GC seq_cons                        ...................IhhYh..oaSP..Cs-....CspKIhsFL.......t+as...pV.s.ls...IYhupLYah-......................sppNRpGL+sLsSLh...cVTlpshsh.t...................................................
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