GenomeNet

Database: Pfam
Entry: AbiJ_NTD5
LinkDB: AbiJ_NTD5
Original site: AbiJ_NTD5 
#=GF ID   AbiJ_NTD5
#=GF AC   PF18865.4
#=GF DE   AbiJ N-terminal domain 5
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF SE   Iyer LM
#=GF GA   26.70 26.70;
#=GF TC   27.10 47.80;
#=GF NC   25.00 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   23768067
#=GF RT   Comprehensive analysis of the HEPN superfamily: identification
#=GF RT   of novel roles in  intra-genomic conflicts, defense,
#=GF RT   pathogenesis and RNA processing.
#=GF RA   Anantharaman V, Makarova KS, Burroughs AM, Koonin EV, Aravind L;
#=GF RL   Biol Direct. 2013;8:15.
#=GF DR   INTERPRO; IPR040508;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Mostly alpha helical. Found fused to AbiJ-lke HEPN, and to other
#=GF CC   domains presumably involved in defense [1].
#=GF SQ   40
#=GS Q7WXI6_CUPNH/11-102       AC Q7WXI6.1
#=GS A0A4Y4CXW2_ZOORA/1-93     AC A0A4Y4CXW2.1
#=GS A0A0A0ESZ8_9GAMM/11-101   AC A0A0A0ESZ8.1
#=GS A0A1W2BVH5_9RHOB/1-68     AC A0A1W2BVH5.1
#=GS Q2IKC4_ANADE/23-115       AC Q2IKC4.1
#=GS A0A2A2SIB7_9SPHN/1-93     AC A0A2A2SIB7.1
#=GS I2GRD4_9BACT/4-96         AC I2GRD4.1
#=GS A0A5C6E9N3_9BACT/10-102   AC A0A5C6E9N3.1
#=GS A0A317C352_9GAMM/1-93     AC A0A317C352.1
#=GS Q7WXI7_CUPNH/10-99        AC Q7WXI7.1
#=GS E8N9G5_MICTS/7-79         AC E8N9G5.1
#=GS A0A2M9BAT9_9BACT/1-93     AC A0A2M9BAT9.1
#=GS A0A087BE75_9BIFI/2-95     AC A0A087BE75.1
#=GS A0A6L8LC03_9BURK/9-100    AC A0A6L8LC03.1
#=GS A0A090P3S2_9VIBR/1-94     AC A0A090P3S2.1
#=GS A0A6G6Y797_9SPHN/6-96     AC A0A6G6Y797.1
#=GS X5DE63_9BACT/2-93         AC X5DE63.1
#=GS A0A1V8RQD5_9RHIZ/3-95     AC A0A1V8RQD5.1
#=GS I0K6N7_9BACT/4-96         AC I0K6N7.1
#=GS A0A160KQ74_9MICO/4-74     AC A0A160KQ74.1
#=GS A0A1I1PAR1_9BACT/4-93     AC A0A1I1PAR1.1
#=GS A0A2T0TII6_9BACT/4-95     AC A0A2T0TII6.1
#=GS A0A327NUD6_9BACT/4-96     AC A0A327NUD6.1
#=GS A0A4T2AAG6_9RHOB/23-106   AC A0A4T2AAG6.1
#=GS A0A1M7QQY0_9ACTN/8-79     AC A0A1M7QQY0.1
#=GS I3ZEJ2_TERRK/7-99         AC I3ZEJ2.1
#=GS A0A2A9E4Y3_9MICO/8-73     AC A0A2A9E4Y3.1
#=GS A0A4Y9RIG8_9CAUL/3-95     AC A0A4Y9RIG8.1
#=GS A0A1P8R020_9GAMM/2-94     AC A0A1P8R020.1
#=GS A0A1H3LL93_9RHOB/230-321  AC A0A1H3LL93.1
#=GS A0A6M5YEV2_9BACT/4-96     AC A0A6M5YEV2.1
#=GS A0A1P9X4S9_9BACT/4-95     AC A0A1P9X4S9.1
#=GS A0A6M0IB83_9BACT/4-96     AC A0A6M0IB83.1
#=GS A3VEW7_9RHOB/109-201      AC A3VEW7.1
#=GS A0A517TGW1_9BACT/1-89     AC A0A517TGW1.1
#=GS A0A1I3FS77_9FLAO/1-93     AC A0A1I3FS77.1
#=GS A0A4Q2UEF0_9BACT/4-95     AC A0A4Q2UEF0.1
#=GS A0A1W6E740_9BACT/4-96     AC A0A1W6E740.1
#=GS D5SSN8_PLAL2/1-93         AC D5SSN8.1
#=GS A0A0E4A0H4_9BACT/4-96     AC A0A0E4A0H4.1
Q7WXI6_CUPNH/11-102                  .........d-DAKRNKAFATFAKVLE..RRFSESDWASFG.-HEHNIEEIYGNDHLLRSAQY.GNSDYRLCILRTLEFLFDDYAKALKALLTDASLHNTLKREDP-d.........
A0A4Y4CXW2_ZOORA/1-93                .......mtp---TDRKKVAVIAKYAV..ESFSESDWYSLG.QITGNLKAVTDHPRLLRALSF.GDDDYESCAIQVIDEVFNSDSSSIAEIIEYFDIDLWYSNKAP-e.........
A0A0A0ESZ8_9GAMM/11-101              .......pls-----GKTLLALGEAAE..AQFDSTDWTKFA.YEVDEANLICNHPRLLRSLSF.GDTDYGECVLQVVRHLQNNRPSALGALAQRPKIRTWIEENAP-d.........
A0A1W2BVH5_9RHOB/1-68                .........m-----------------..---------EIG.LLTGWTSYIQGHDRLLRSLSW.SDPDYPGNVLDMLVVMKNRNDGSLEKVQTYVMQKFSNVAT---ats.......
Q2IKC4_ANADE/23-115                  ......dpla----LAKRLIALRARIV..ATFNAGNWEEVG.LLSGQSKIITGHDRLLRSLSW.HDEDYEGNVLTVLRRISDRDVRALDVIEEYLNEKFPGEEKTE-y.........
A0A2A2SIB7_9SPHN/1-93                ..........MSDQDRQYLIRLARIAV..ANFNAGDWKELG.VHLGALDVITGHDRLLRSLSF.ADPDYSGHAHGVLFSLAERNPRNLGTIASFVRDKYGDDGE---lvs.......
I2GRD4_9BACT/4-96                    .........q-SKQKALRLFALHEFIR..DHFTKSDWIKLG.YLTDNQELIEEHPRLLRSLDF.KDDDYEGNIMQVLSKLISENNSNLIEIERIIEDKKLRLS----spty......
A0A5C6E9N3_9BACT/10-102              .....dsvai-----GKQIIGLKNQVV..DGFNESHWRELG.LMTGFQDRVNNHPRLLRSLSW.GDEDYEGLALEFLQQMVHADPANLEVITEFVQSKCPEAG----efis......
A0A317C352_9GAMM/1-93                ..........MNSSERKRVSVISKYAI..ASFTEGDWLTLG.QITGKVKEVTGHGRLFRSLSF.GDDDYSFCVAEVLDSIFSSDTNLINEVVDHFDIDLWYQQKDP-t.........
Q7WXI7_CUPNH/10-99                   .........d-AALRGKLLLAMRKALV..ARFEKLDWIDLG.----FEHEIGIKQRILQGSQFkSNDDYPDLVHDLLVRLYSEKPAVLKALVLHPRLQSAIEADVP-q.........
E8N9G5_MICTS/7-79                    .qdapanlve---------LAIGKCLI..AEMDDSRWTEIG.LLTGTKEQIYKHPRLLRSLRF.NDEDYDGHVYDMVPTLLGAE-----------------------etw.......
A0A2M9BAT9_9BACT/1-93                .........m-TKVSGKEIVALKNRVC..SLFTHDDWLDIA.YITGSEELVKGHYRLLQSLHF.RDDDYERSALEVLKSIADQDKNNIQEIRDFIESKYPDN-----ielks.....
A0A087BE75_9BIFI/2-95                .........i-DRNHIARVKRIKDYVL..NEFDSGDWEFLAtYLGDKGNIISSHPRLLRSLHF.GDEDYAACVGDVLGKLLKEEPEVLDLLEGMVNEKGSESTVV--sa........
A0A6L8LC03_9BURK/9-100               .........d-SKKRGALILALRRAIV..SEFTVEDWREFG.YLSGQSDYIQCHDRLLRSLHW.QDPDYGDCVLQALERFTREGWDIVDQLINHPKL----------sshllteip.
A0A090P3S2_9VIBR/1-94                ........mq---EHQQKIYALRKRIVaiEGFDQADWITIG.DATDCQHIIESHPRLLRALSF.GDPDYPTAVGDVLKSMFAYHRNSLDDVTNFLDRNYPLA-----nnvsv.....
A0A6G6Y797_9SPHN/6-96                ........ls--DSDRKRLIALTRIAV..TNFNSGDWQILG.AETGAMDVVTGHDRLLRSLSF.GDPDYSGNAHAVMFQIVGRDPANLQRIEDVI------------igmygepeva
X5DE63_9BACT/2-93                    .........i-KKEQQKELIDIKNQIA..KHFTKSDWLDLG.YSLGCYDVIEGHSRLLKSLSF.GDEDYEGNILEVLTEILKRDQKNFNEIKSYIENKFAT------plvsd.....
A0A1V8RQD5_9RHIZ/3-95                .........v-DAEQRRKVVEFKNIAV..ANFSSSNWIELG.SLTDRFDLVNDHPRLLRSLSF.GDDDYDGCALQVLMAMVEHAPENFGEVERYITSRFGGGGES--vs........
I0K6N7_9BACT/4-96                    .........p-TKLQTQRLFALHDFVR..EQFTKMDWYRLA.YLTDTLDLIEDHPRLLRSLDF.DDDDYDGNSLQVLLKLISLNPQHLDTLDEYVADRKARAVH---pti.......
A0A160KQ74_9MICO/4-74                mdalqlaaga--------------YTA..DTWDQSNWREFG.RETGMSDILSQHSRLYRSQDF.GDDDYPDAALEVLGWILT-------------------------ghaacfs...
A0A1I1PAR1_9BACT/4-93                .........q-TKQKTLRLFALHEFIQ..DHFTKSDWIKVG.YLTDSVELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESHSNLYEIERFVEAKKA-------tfir......
A0A2T0TII6_9BACT/4-95                .........p-NRQRTARLFALHEFAR..DHFTKSDWFRIA.HLTDTVELIEDHPRLLRSLDF.RDDDYEGNSLQVLSKIISVGATNLAELERYVEEQKSRVA----har.......
A0A327NUD6_9BACT/4-96                .........q-NKQRTFRLFALHEFIQ..DHFTKSDWIKVG.YLTDSLELIEDHPRLFRSLDF.KDDDYEGNSLQVLSKLISESTSNLYEIERFVDVKKSTMNR---sir.......
A0A4T2AAG6_9RHOB/23-106              .......rfk---------VELAEIVA..NAYRISDWKKFA.HRFGLEEEILDHPRFTRSMEW.GDEDYEGHVLDLVDYLCSKNIPALTALFEIPSV----------qsklsdd...
A0A1M7QQY0_9ACTN/8-79                ......niik---------LAVARAII..DTFDQGKWHEIG.LITNTLDDIEGHPRLLRSMRF.GDDDYSACVYQMIPIILDEQT----------------------gskgia....
I3ZEJ2_TERRK/7-99                    ........ta--LSHEARILRVKKIAL..EHFKEEHWTEMA.SEIGCADLLIVREESLGSVSW.GDDAYAATVLKILAAIVQRNPSDIEKLEIYAEKCLSHAEAG--sf........
A0A2A9E4Y3_9MICO/8-73                ........qn----------AIAAYAA..DKWTDTEWRVFG.RETGTSDIIDGHSRLYRSLGF.GDDDYPDAAAEVVRQILASE-----------------------avee......
A0A4Y9RIG8_9CAUL/3-95                .......ldp---HSGKRVLQIARVAG..DKFTEGKWLELG.LLTNSHDIVTGHSRLLRSLSW.GDPDYPDNVLAVLTQIVARDEANLGIIENYLSGEIE-------pegenis...
A0A1P8R020_9GAMM/2-94                ........ps--RISGQELIQLKDAIV..QDFDSSNWRELG.ALTNMIDEVDRHPRLLRSLSF.GDPDYDGLALTFLRKMIGQEDENLDIALKYIHKTCGDAGENV-s.........
A0A1H3LL93_9RHOB/230-321             .....pqpdp------LNLIQIKDIMV..DKFDQENFLEIG.VVTGWTNHIRRHPRLLRSLSW.GDPDYPGNVLDLITAMDEAQDGSIDKLKSYIDSKFSSEY----raat......
A0A6M5YEV2_9BACT/4-96                .........q-NKQRTARLFALHEFVR..EHFTKSDWFKIA.YLTDCVELVEDHPRLLRSLDF.RDDDYDGNSLQVLSKMINESNSNLYELERYVELRKAAI-----krpvs.....
A0A1P9X4S9_9BACT/4-95                .........p-TKQRTARLFALHEFIR..ERFTKADWFRIA.HLTNCLELVEDHPRLLRSLDF.RDDDYDGNSLQVLSKIIGESNTNLYEIERYVELRKAT------irrsd.....
A0A6M0IB83_9BACT/4-96                .........q-NKYRTRRLFDLHEFIQ..DHFTKSDWIKVG.YLTDSVELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESSGNLHELEHFVEAKKATMTRP--vr........
A3VEW7_9RHOB/109-201                 .........s-HSAEPLNLLQLKDLIV..ENFDQENFLEIG.VLSGWTNQIRNHSRLLRSLSW.RDPDYPGNVLDLITRMDDAGDGSIEKLRTYIEEKFSIEAQA--at........
A0A517TGW1_9BACT/1-89                .........m----KGQEFIDLKNRIK..ENFTDSDWRELA.VLVDAERLITADDRLLRSLRF.GDDDYEGCILKVLRRVFDADEANVEIVLNFLEERCGPE-----geci......
A0A1I3FS77_9FLAO/1-93                ..........MDKTQGKELLEIKNIIL..KQFGQSEWLELG.FYLGCNDIIENHPRLLRSLSF.GDEDYEGNVLTVLDEIIKLDTNNFKEIKIYLSEKFSNPQVSE-y.........
A0A4Q2UEF0_9BACT/4-95                .........e-TKQRTARLFALHEFVR..AYFTKADWFRVA.YLTDNVDLIEDHPRLLRSLDF.RDDDYDGNSLQVLSKLIGEGTSNLTELERYVDSRKAS------lsrya.....
A0A1W6E740_9BACT/4-96                ........lt--SSQMQQLFALHEYIR..DQFTKMDWIKLA.YITDSLDLIEDHPRLLRSLDF.NDDDYEGNSLQVLARIVGNDSAYLADIEQFVNDKKANGKKPP-a.........
D5SSN8_PLAL2/1-93                    ..........MNSANRKKVAVITSYVQ..QSFSESDWYAIG.QLTGQLNTISGHSRLLRALNF.GDDDYSGCAAEVLDRIFSANESAIDEVIDHFDIDLWYQQKSP-e.........
A0A0E4A0H4_9BACT/4-96                .........q-NKQRTLRLFALHEFIQ..DHFTKSDWIKVA.YLTDSLELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESNSNLYEIEHFVEAKKVTMNRP--nr........
#=GC seq_cons                        ............ttpttclhsl+chlh..cpFscuDWhclG.hlTssh-lIpsHsRLLRSLsF.uD-DYsGssLpVLspllspssssLtplppalct+hs.......s.........
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