#=GF ID   AcrIF11_ADP_ribosyl
#=GF AC   PF26151.1
#=GF DE   Anti-CRISPR Type I-F ADP-ribosyltransferase AcrIF11
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   UniProtKB:A0A0R6PCF0
#=GF GA   25.40 25.40;
#=GF TC   25.40 26.30;
#=GF NC   24.70 24.30;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0084
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents the AcrIF11 family of
#=GF CC   ADP-ribosyltransferases that function as anti-CRISPR proteins
#=GF CC   targeting Type I-F CRISPR-Cas systems. These enzymes are encoded
#=GF CC   by bacteriophages and plasmids, and inhibit CRISPR-Cas immune
#=GF CC   systems by ADP-ribosylating the Csy1/Cas8 component of the
#=GF CC   surveillance complex. This modification prevents target DNA
#=GF CC   binding and renders the CRISPR system inactive. Unlike
#=GF CC   stoichiometric inhibitors, these enzymatic anti-CRISPRs can
#=GF CC   remain potent even when CRISPR components are overexpressed. The
#=GF CC   modification occurs specifically at asparagine 250 of Csy1. The
#=GF CC   enzyme structure contains a beta sheet catalytic domain with
#=GF CC   conserved aspartate and glutamate residues critical for
#=GF CC   ADP-ribosylation activity.
#=GF SQ   17
#=GS A0A348HI59_9GAMM/33-146  AC A0A348HI59.1
#=GS A0A0R6PCF0_9CAUD/2-154   AC A0A0R6PCF0.1
#=GS A0A2I8DIK8_9BURK/5-148   AC A0A2I8DIK8.1
#=GS A0A1X0WAV6_9GAMM/1-158   AC A0A1X0WAV6.1
#=GS A0A171KSG2_9BURK/1-143   AC A0A171KSG2.1
#=GS A0A9X0RB49_VIBME/4-176   AC A0A9X0RB49.1
#=GS A0A873WQH9_9CAUD/1-156   AC A0A873WQH9.1
#=GS A0A1Y6CNV1_9BACT/10-152  AC A0A1Y6CNV1.1
#=GS A0A513SP30_9CAUD/23-158  AC A0A513SP30.1
#=GS A0A0C5E4D1_9PSED/1-136   AC A0A0C5E4D1.1
#=GS E5Y9T8_BILW3/1-153       AC E5Y9T8.2
#=GS E5AGG6_9CAUD/1-152       AC E5AGG6.1
#=GS A0A1V0B6D0_9GAMM/1-149   AC A0A1V0B6D0.1
#=GS A0A6M8UEM7_9GAMM/1-150   AC A0A6M8UEM7.1
#=GS A0A0R6PGI4_9CAUD/2-154   AC A0A0R6PGI4.1
#=GS E2X2S7_SHIDY/1-45        AC E2X2S7.1
#=GS A0A1W1Y824_9HYPH/4-174   AC A0A1W1Y824.1
A0A348HI59_9GAMM/33-146             mtagdyhvfvtslndseiieagslwyqdnweaarpfidelmgrlsvdedtamglldgsl---------------------.------.---------------.---.-...------..-..-..---...........----....---------------------.-------.---.---....-SVYD..MDIEP..E.DMAD..-E-.......-DWNVQRLTARSAKALGFIGVAVEDEQGAAYMLD.VTR----ikme......
A0A0R6PCF0_9CAUD/2-154              ..........................................................t-TLYHGSHENTAPVIKIGFAAfLPADNV.FDGIFANGDKNVARS.HGD.F...IYAYEV..D..S..IAT...........NDDL....DC--DEAIQIIAKELYIDEET.AAPIAEA.VAY.EES....LAEFE..EHIMP..R.SCGD..CAD.......FGWEMQRLRGVIARKLGFDAVECVDEHGVSHLIV.NANIRG-s.........
A0A2I8DIK8_9BURK/5-148              ...........................................................MELFHTSPSEISS---IGTAG.RFGSF-.---LFFSGHVYNMTA.GES.V...VYGLEI..D..E..AAIieag...qlffHADA....EK-LAPLVAELAHRLGVDEDD.AE----A.LIE.ESQ....SVYDV..DGIEA..E.DAAD..---.......ASWDVQHYTARAAALLGFRGVAINDEQGTAYMI-.-------dmqgr.....
A0A1X0WAV6_9GAMM/1-158              ...........................................................MKLFHGSYSSIAPVIKIGANA.MSGDNL.FDGLFASADREIADS.HGG.LensIHCYEV..S..N..IAE...........SSDL....NARIDEVIAFLYTEIEAESDV.LEALAYA.IAD.DEE....TDEFN..DVLSP..R.SFAD..HQG......aFSWELQRLRGRVAAHLGFDAVEMSDEHGISYLIV.NPKITA-r.........
A0A171KSG2_9BURK/1-143              ..............................................melihtspseike---------------------.IRANGR.FDSFLFFSAHEYSMS.VGQhV...AYSIEI..D..EdqIIEas......rlfYHDG....AEKLQALVDDLASRYDIDSDD.AEALIEG.KI-.---....--SAH..DIIDD..A.D--E..AAD.......ASWDAQLYAARAAVLLGYRGVAVEDEQGMAYMI-.-------dmlgr.....
A0A9X0RB49_VIBME/4-176              ...................................................tdfyhank------SANGIALRLDVGVLN.DDVSNV.FDGFFANENPETLKS.YED.KgmsIYKCSInkE..N..IIS...........SRNL....QK-TPENMAILKSICNVDDGNiLDMFSDF.IFL.GRSnivdLEAFI..DVIPT..KaDYTP..NATkagklnfLKHEIIRLKGRIAAKLGYDGIKMTIKGQTLVLIV.NPLI---ewq.......
A0A873WQH9_9CAUD/1-156              ...............................miithasaeritevkarspyalflkgcl---------------------.------.----FFAAEGNEYNL.AGE.Cn.yQYNLEV..N..N..IIDves.....ffsHHDI...aEQAVQQVIELVRDDLEIEASD.-EEIAEL.LSN.ESS....IRDFE..F----..N.GYDD..EGE.......ADWAIQQYQGILAHKLGYDCAKSSDEQGVIYI--.-------aycvdremqe
A0A1Y6CNV1_9BACT/10-152             ...............................vieefhskglfgeflcfsqdeylmgdvk---------------------.------.---------------.---.A...VYSVEL..D..D..SDVirarslfyvdeADKL....DAIVKKVIDACP--IEIDEEE.AQDLLDE.--S.SSY....YDLIS..EKSES..Q.DYES..TAE.......FSWWLQLMTAQCAKALGYKACLMEDEQGAVYFV-.-------dvtqvqp...
A0A513SP30_9CAUD/23-158             .................................................nkmfhtspka--------------IEIGTI-.-NKYGVaGDCLFFSDDIYIMTAsRTC.Y...VYEADF..D..C..VRA...........S-QL....YD--DEIIADIARYFDVDEST.AESLLDG.TQN.EWC....LDDFD..-----..-.-CEG..EN-.......-SWWLQGKRGECAVKMGYDGCEDEDEQGTVYIV-.-------pmagre....
A0A0C5E4D1_9PSED/1-136              ....................melfhtspkeitsidkhgrfgeflffssdvyvmtagdhv---------------------.------.---------------.---.-...------..-..-..-VY...........RAQI....DD--DAIIAANHLFYHADAAK.LDELVAKfCARfDVD....TDTAE..EIISE..R.QQLDtgDAD.......DDWDVQIYTARAAKILGYRAVAVSDEQGTAYMV-.-------dmlg......
E5Y9T8_BILW3/1-153                  ...........................................................MKLYHGSMIEHLA---ISNSG.TGLGYN.FGAMFFARTYGTAKG.YGN.Y...VYQCEI..DikD..IFL...........NEDLpyleDGAAGTALREVMAERGIDEKY.FDLCWYA.VVE.EKI....GYQDE..DWVNL..L.NMDD..-DD.......ASWEAQAMRIAFARKLGFNGCDMNDECGSI----.-------allpeyia..
E5AGG6_9CAUD/1-152                  ...........................................................MKLFHGSYNSTAPEIKVGAFA.MSGDNV.FDGLFTSSDIEIAGS.HGD.F...VHSYEV..D..N..IAE...........SSDL....NDRIDEVVTFLADELGIDAEE.AAEIAEA.IAE.DEC....DDSFS..HLVSP..R.SCTE..NAS.......--WEMQRLRGRVAAHLGFDAVEMNDEHGTSYLIV.NQKITA-v.........
A0A1V0B6D0_9GAMM/1-149              ...........................................................MQLFHGSYETISE--------.IKNQGL.FGGLFAADSEASALA.HGD.V...LHVIEI..E..D..SKAltq.....svlSYEL....DH--EAVMAALNEVAGHWCED.LDRLYEL.AIE.EAQ....VKDAD.iELLKA..E.DWAD..---.......AGWEAQRIRGQVAKALGFQAVEMSDEHGTTWLVMpGANIRE-a.........
A0A6M8UEM7_9GAMM/1-150              ...........................................................MKLFHGSFSDKAPVIKVGEFA.MSGDNV.FDGIFASADSDIAAS.HGD.F...VHCYNI..N..S..VAD...........SAAL....NDRIGEVVAFLASE--VETDD.AETLAYA.IAD.DEC....DDRFA..DLLTP..R.SCTG..DA-.......-GWEMQRLRGRVAAHLGFDAVEMNDEHGTSYLIV.NPSIFA-e.........
A0A0R6PGI4_9CAUD/2-154              ..........................................................t-TLYHGSHENTAPVIKIGFAAfLPADNV.FDGIFANGDKNVARS.HGD.F...IYAYEV..D..S..IAT...........NDDL....DC--DEAIQIIAKELYIDEET.AAPIAEA.VAY.EES....LAEFE..EHIMP..R.SCGD..CAD.......FGWEMQRLRGVIARKLGFDAVECVDEHGVSHLIV.NANIRG-s.........
E2X2S7_SHIDY/1-45                   ...........................................................MKLIHGAYEKAAPIIKIGEFA.MSGNNV.SDGLFASPERDIAAS.H--.-...------..-..-..---...........----....---------------------.-------.---.---....-----..-----..-.----..---.......----------------------------------.-------er........
A0A1W1Y824_9HYPH/4-174              ...........lhlvhcspvadlkvtkahahaafdcclfftgveadlddaeaicegayv---------------------.------.------------TSI.DGD.H...IHVLDV..EwdY..IAA..........rGLDL....DEQAERDIRKIFSQAWEAAED.RREMECE.GDD.RAF...vRREFDptDILRGdeE.AFVD..EDG......kASWALQRIRAQTARRAGYTAVKDWDEQGDVYIV-.-------dfaeren...
#=GC seq_cons                       ...................................................................................ht....sshFhssp.t.htu.tss.h...lash-l..-..s..lht...........stcL....sp..ppslthltp.htl-pcs.hc.lhtt.hhp.-tp....hpphp..-hlps..c.shs-..pst.......huW-hQphpupsAttLGacuVchsDEpGssYhl.........sh........
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