GenomeNet

Database: Pfam
Entry: Adeno_E3_CR1
LinkDB: Adeno_E3_CR1
Original site: Adeno_E3_CR1 
#=GF ID   Adeno_E3_CR1
#=GF AC   PF02440.18
#=GF DE   Adenovirus E3 region protein CR1
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1854 (release 5.4)
#=GF GA   26.00 26.00;
#=GF TC   26.00 26.30;
#=GF NC   25.90 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0011
#=GF RN   [1]
#=GF RM   8627757
#=GF RT   Early region 3 of adenovirus type 19 (subgroup D) encodes an
#=GF RT   HLA-binding protein distinct from that of subgroups B and C. 
#=GF RA   Deryckere F, Burgert HG; 
#=GF RL   J Virol 1996;70:2832-2841.
#=GF DR   INTERPRO; IPR003471;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Early region 3 (E3) of human adenoviruses (Ads) codes for
#=GF CC   proteins that appear to control viral interactions with the host
#=GF CC   [1]. This region called CR1 (conserved region 1) [1] is found
#=GF CC   three times in Adenovirus type 19 (a subgroup D virus) 49 Kd
#=GF CC   protein in the E3 region. CR1 is also found in the 20.1 Kd
#=GF CC   protein of subgroup B adenoviruses. The function of this 80
#=GF CC   amino acid region is unknown. This region is probably a
#=GF CC   divergent immunoglobulin domain (A. Bateman pers. observation).
#=GF SQ   28
#=GS I3WF37_9BETA/30-134      AC I3WF37.1
#=GS B9A6D9_9ADEN/110-200     AC B9A6D9.1
#=GS Q6QP94_9ADEN/15-113      AC Q6QP94.1
#=GS A0A1W2KEW8_ADE04/16-113  AC A0A1W2KEW8.1
#=GS K7ZQ33_ADE08/110-200     AC K7ZQ33.1
#=GS Q6QP95_9ADEN/16-114      AC Q6QP95.1
#=GS G8XTR8_SCMVC/25-127      AC G8XTR8.1
#=GS Q9PX39_ADE07/13-100      AC Q9PX39.1
#=GS Q9PX68_ADE07/13-104      AC Q9PX68.1
#=GS Q8BEL2_ADE04/22-115      AC Q8BEL2.1
#=GS A0A6G1PUE3_9TELE/26-118  AC A0A6G1PUE3.1
#=GS Q6QP93_9ADEN/15-105      AC Q6QP93.1
#=GS Q7TFV8_RHCM6/30-134      AC Q7TFV8.1
#=GS A0A0K1H002_9BETA/31-137  AC A0A0K1H002.1
#=GS A0A1L6Z0Q1_9BETA/31-137  AC A0A1L6Z0Q1.1
#=GS Q2Y0G3_ADE03/13-100      AC Q2Y0G3.1
#=GS G8XTR9_SCMVC/21-123      AC G8XTR9.1
#=GS E1AI32_9ADEN/241-326     AC E1AI32.1
#=GS E1AI32_9ADEN/110-200     AC E1AI32.1
#=GS K7ZQ33_ADE08/15-105      AC K7ZQ33.1
#=GS A0A3G9K5Y5_ADE04/22-115  AC A0A3G9K5Y5.1
#=GS E1AI32_9ADEN/15-105      AC E1AI32.1
#=GS K7ZQ33_ADE08/236-321     AC K7ZQ33.1
#=GS Q2Y0G4_ADE03/13-104      AC Q2Y0G4.1
#=GS B9A6D9_9ADEN/260-345     AC B9A6D9.1
#=GS A0A3G9JU39_ADE04/16-113  AC A0A3G9JU39.1
#=GS I3WEY5_9BETA/38-141      AC I3WEY5.1
#=GS B9A6D9_9ADEN/15-105      AC B9A6D9.1
I3WF37_9BETA/30-134                 sskkitcip---------VNSTAGRNVTLN....PPpfnhHTTYVY......WY.R-QL.....GKGKNELCRy..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN----.--....-----------ldlglgttsttcytltvkta
B9A6D9_9ADEN/110-200                ........v-KPQPEPEYVFVYMGENKTLE....GP....PGTPVT......WF.----.....NQDGKKFCE.....GE..KVLHPEFN......HTC..DKQ.NLILLFVNFTHDGAYLGYNHQG.TQ....RTHYEVTVLD-l...................
Q6QP94_9ADEN/15-113                 .......al--CNSDNEDVTVVVGSNYTLK....GP....AKGMLS......WYcWFGT.....DEQQTELCN.....AQ..KGKTSNSKi...snYQC..NGT.DLVLLNVTKAYAGSYTCPGDDA.DN....MIFYKVEVVDP....................
A0A1W2KEW8_ADE04/16-113             ........f-INSFDHKNVTAYVGSNCVLT....GY...qSHQRVS......WY.WFDK.....KNTAYTLCK.....GN..QRPTQRSGl....yYSC..TNN.NITLLQVTKQYSGTYYGTNFNT.EQ....DTYYSVKVLDP....................
K7ZQ33_ADE08/110-200                .....rkpl----SEPHYVTVTMDHNITLV....GP....LNLPVT......WY.----.....DGEGNKFCD.....GE..KVEHAEFN......HTC..NIQ.NLTLLFVNLTHNGAYIGYTKDG.SD....RELYEVSVKT-l...................
Q6QP95_9ADEN/16-114                 ........v-IHGMSNEKITIYTGTNHTLK....GP...eKATEVS......WYcYFNE.....SDVSTELCG.....NN..NKKNESITl...ikFQC..-GS.DLTLINITRDYVGMYYGTTAGI.SD....MEFYQVSVSEP....................
G8XTR8_SCMVC/25-127                 ..rckhtwl---------INATVNTNVTLN....GTm.vlNDCSIG......WY.--RN.....YGAYEPLCQ.....YD..ATKSDKMTtykkihYTC..QNS.SLIIFNVNRSASGEYFTYGHYH.--....-----------ydclrekicykliill....
Q9PX39_ADE07/13-100                 ........a-AVTYGRSHLTVPVGSTCTLQ....GP....QQGYVT......WW.RIYD.....NGGFARPCD.....QP..GTK-----......FSC..NGR.DLTIINITSNEQGFYYGTNYKD.--....SLDYNIIVVP-a...................
Q9PX68_ADE07/13-104                 ........v-TVAHGQTIIHITLGHNHTLV....GP...pITSEVI......WT.KLGS.....VDYFDIICN.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS.SQ....YKNYLVRITQP....................
Q8BEL2_ADE04/22-115                 ...prvsfi-------KPVNVTEGSNVTLV....GV...eGAKNTT......WT.KYHL.....NGW-KDICN.....WS..VTV-----......YTC..EGV.NLTIVNATSAQNGRIQGQSVSD.SE....-----------gyytqhtfiydikvip....
A0A6G1PUE3_9TELE/26-118             ......lei---TPDDKQIVLVKGSSLTLS....CS....GTGETT......WE.-FKK.....EDTQTQVQN.....DG..ERY-KIVQ......SNA..TST.ALTLLNVNWSHTGVYQCFDRHA.AK....IKEVAVFV---pdd.................
Q6QP93_9ADEN/15-105                 .ivfsagfl-------KNLTIYEGENATLV....GI....SGQNVS......WL.KYHL.....DGW-KDICD.....WN..VTV-----......YTC..NGV.NLTITNATQDQNGRFKGQSFTRnNG....YESHNMFIYD-v...................
Q7TFV8_RHCM6/30-134                 sskkitcip---------VNSTAGRNVTLN....PPpfnhHTTYVY......WY.R-QL.....GKGKNELCRy..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN----.--....-----------ldlglgttsttcytltvkta
A0A0K1H002_9BETA/31-137             ...hkcskt-------ETRTGTVGTNITLV....TSpppnNKGLLY......WY.KPNC.....-TSNDRLCDysgftGN..NAVSNKTKl....kFSCmnNST.KLTLINVTAHYSGQYCSRTITS.NG....S----------vdicfnvtihl.........
A0A1L6Z0Q1_9BETA/31-137             ...hkcskt-------ETRTGTVGTNITLV....TSpppnNKGLLY......WY.KPNC.....-TSNDRLCDysgftGN..NAVSNKTKl....kFSCmnNST.KLTLINVTAHYSGQYCSRTITS.NG....S----------vdicfnvtihl.........
Q2Y0G3_ADE03/13-100                 ........a-AVTYGRSHLTVPVGSTCTLQ....GP....QEGYVT......WW.RIYD.....NGGFARPCD.....QP..GTK-----......FSC..NGR.DLTIINITSNEQGFYYGTNYKN.--....SLDYNIIVVP-a...................
G8XTR9_SCMVC/21-123                 .....hcsn----PGDIPISLKLGDNVTLN....GT...lQSNHST......RY.WYHN.....ETVLCKCTS.....GNpeTASNRKIT......FQC..HRNcSLTLINATVSHAGNYCVMNDFK.DEnptlQLCYNVTI---lss.................
E1AI32_9ADEN/241-326                ........s-TNNLQPTQLYVRPFTNVSLT....GP....PNGKVT......WY.----.....DGELNDPCE.....QK..YKLR----......TFC..NQQ.NLTLINVSSTYDGIYYGTDEKD.-K....ANRYRIKVNT-t...................
E1AI32_9ADEN/110-200                .....rkpl----SEPHYVTVTMGDNITLV....GP....SDLPVT......WY.----.....DGEGNKFCD.....GE..KVEHAEFN......HTC..NIQ.NLTLLFVNLTHNGAYIGYNKDG.SD....RELYEVSVKT-l...................
K7ZQ33_ADE08/15-105                 ........a-FSQAGIINLNVLWGINLTLV....GP....LDLPVT......WY.----.....DKKGMQFCI.....GN..TIKNPQIK......HSC..DQQ.NLTLLNADKSHERTYLGYRHDS.KG....KVDYKVTVIPP....................
A0A3G9K5Y5_ADE04/22-115             ...prvsfi-------KLVNVTEGGNVILV....GV...eGAKNTT......WT.KYHL.....NGW-KNICN.....WS..VTV-----......YTC..EGV.NLIIANATSAQNGRIQGQSVSD.SN....-----------gyytqhtfiydikvip....
E1AI32_9ADEN/15-105                 ........a-FSQAGIINLNVSWGMNLTLV....GP....SDLPVT......WY.----.....DGKGMQFCD.....GN..TIKNPQIK......HSC..NQQ.NLTLLNADKSHERTYLGYRHDS.KE....KVDYKVTVIPP....................
K7ZQ33_ADE08/236-321                ........s-TNNLQPTQLYVRPFTNVSLT....GP....PNGKVI......WY.----.....DGELNDPCE.....QK..YKLR----......TFC..NQQ.NLTLINVTSTYDGIYYGTDEKD.-K....ANRYRIKVNT-t...................
Q2Y0G4_ADE03/13-104                 ........v-TVAHGQTIVHITLGHNHTLV....GP...pITSEVI......WT.KLGS.....VDYFDIICN.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS.SQ....YKNYLVRITQP....................
B9A6D9_9ADEN/260-345                ......pat----IEAMLVTVTAGSNLTLV....GP...kAEGKVT......WF.----.....DGDLKRPCE.....PN..YRLR----......HEC..NNQ.NLTLINVTKDYEGTYYGTNDKD.-E....GKRYRVKVNT-t...................
A0A3G9JU39_ADE04/16-113             .......si--SSFDHKNITAYVGSNCVLT....GY...qSHQRVS......WY.WFDK.....KNTAYTLCK.....GY..HQPTQRGGl....yYSC..TNN.NITLLQVTKQYSGTYYGTNFNT.KQ....DTYYSVEVLDP....................
I3WEY5_9BETA/38-141                 ...faynvt--------HVSGYEHSNVTLH....TS...iSHSNIShmnvgyWI.RYNY.....PVNSYTICT.....VS..GNNVASTKhn.gwfFEC..NGT.SLTLHNLNADHTGSYLFKNLLG.-L....MEHYTVTVLP-i...................
B9A6D9_9ADEN/15-105                 ........a-FSQAGFHTINATWWANITLV....GP....PDTPVT......WY.----.....DTQGLWFCN.....GS..RVKNPQIR......HTC..NDQ.NLTLIHVNKTYERTYMGYNRQG.TK....KEDYKVVVIP-p...................
#=GC seq_cons                       ........s.....t.p.lslshGsNlTLs....GP....sss.Vo......WY.h.t......ssthpchCs.....ss..pshp.p.t......asC..ssp.sLTLlNVopsasGpYhGhshps.pp.......Ypl.V...h...................
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