GenomeNet

Database: Pfam
Entry: Adeno_E3_CR1
LinkDB: Adeno_E3_CR1
Original site: Adeno_E3_CR1 
#=GF ID   Adeno_E3_CR1
#=GF AC   PF02440.17
#=GF DE   Adenovirus E3 region protein CR1
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1854 (release 5.4)
#=GF GA   26.00 26.00;
#=GF TC   26.00 26.90;
#=GF NC   25.90 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0011
#=GF RN   [1]
#=GF RM   8627757
#=GF RT   Early region 3 of adenovirus type 19 (subgroup D) encodes an
#=GF RT   HLA-binding protein distinct from that of subgroups B and C. 
#=GF RA   Deryckere F, Burgert HG; 
#=GF RL   J Virol 1996;70:2832-2841.
#=GF DR   INTERPRO; IPR003471;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Early region 3 (E3) of human adenoviruses (Ads) codes for
#=GF CC   proteins that appear to control viral interactions with the host
#=GF CC   [1]. This region called CR1 (conserved region 1) [1] is found
#=GF CC   three times in Adenovirus type 19 (a subgroup D virus) 49 Kd
#=GF CC   protein in the E3 region. CR1 is also found in the 20.1 Kd
#=GF CC   protein of subgroup B adenoviruses. The function of this 80
#=GF CC   amino acid region is unknown. This region is probably a
#=GF CC   divergent immunoglobulin domain (A. Bateman pers. observation).
#=GF SQ   30
#=GS A0A075J1P3_9ADEN/13-100  AC A0A075J1P3.1
#=GS A0A075IKX3_9ADEN/13-104  AC A0A075IKX3.1
#=GS B9A5K1_ADE08/236-321     AC B9A5K1.1
#=GS I3WF37_9BETA/30-134      AC I3WF37.1
#=GS Q6SXC3_HCMV/115-217      AC Q6SXC3.1
#=GS A0A1W2KEW8_ADE04/16-113  AC A0A1W2KEW8.1
#=GS A0A2L1F3C9_9ADEN/16-113  AC A0A2L1F3C9.1
#=GS B9A5K1_ADE08/110-200     AC B9A5K1.1
#=GS G8XT84_SCMVC/25-127      AC G8XT84.1
#=GS Q6QPD0_9ADEN/15-113      AC Q6QPD0.1
#=GS W8CZR6_9ADEN/15-106      AC W8CZR6.1
#=GS Q9PX39_ADE07/13-100      AC Q9PX39.1
#=GS Q9PX68_ADE07/13-104      AC Q9PX68.1
#=GS W8CZR6_9ADEN/219-302     AC W8CZR6.1
#=GS B9A6H5_9ADEN/110-200     AC B9A6H5.1
#=GS Q8BEL2_ADE04/22-115      AC Q8BEL2.1
#=GS Q7TFV8_RHCM6/30-134      AC Q7TFV8.1
#=GS A0A0K1H002_9BETA/31-137  AC A0A0K1H002.1
#=GS Q6QPD1_9ADEN/15-112      AC Q6QPD1.1
#=GS A0A075IIG1_9ADEN/13-100  AC A0A075IIG1.1
#=GS A0A0B4SHJ0_9ADEN/13-104  AC A0A0B4SHJ0.1
#=GS B9A5K1_ADE08/15-105      AC B9A5K1.1
#=GS B9A6H5_9ADEN/248-333     AC B9A6H5.1
#=GS Q6QPC9_9ADEN/21-114      AC Q6QPC9.1
#=GS B9A6H5_9ADEN/15-105      AC B9A6H5.1
#=GS G8XT85_SCMVC/21-123      AC G8XT85.1
#=GS A0A2L1F3C8_9ADEN/22-115  AC A0A2L1F3C8.1
#=GS G8XT76_SCMVC/110-209     AC G8XT76.1
#=GS I3WEY5_9BETA/38-141      AC I3WEY5.1
#=GS W8CZR6_9ADEN/110-200     AC W8CZR6.1
A0A075J1P3_9ADEN/13-100             ........a-AVTYGRSHLTVPVGSTCTLQ....GP....QE...GY..VT......WW.RIYDNGGFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITLNEQGFYYGTNYKN--....SLDYNIIVVP-a...................
A0A075IKX3_9ADEN/13-104             ........v-TVAHGQTIVHITLGHNHTLV....GP...pIT...SE..VI......WT.KLGSVDYFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSSSQ....YKNYLVRITQP....................
B9A5K1_ADE08/236-321                ........s-TNNLQPTQLYVRPFTNVSLT....GP....PN...GK..VI......WY.----DGELNDPC.....E.....QK..YKLR----......TFC..NQQ.NLTLINVTSTYDGIYYGTDEKD-K....ANRYRIKVNT-t...................
I3WF37_9BETA/30-134                 sskkitcip---------VNSTAGRNVTLN....PPpfnhHT...TY..VY......WY.R-QLGKGKNELC.....Ry..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN------....-----------ldlglgttsttcytltvkta
Q6SXC3_HCMV/115-217                 ....tcgrs----YEVINVTGHVGSNVTLK....KC....NHtiwHN..VD......WI.KYEEPYSSYKMC.....E.....LG..NYHQTTPRgn..icFEC..NDT.SLTIYNLTAENAGKYTRRDRYNGY....EENYYVTVL--se..................
A0A1W2KEW8_ADE04/16-113             ........f-INSFDHKNVTAYVGSNCVLT....GY...qSH...QR..VS......WY.WFDKKNTAYTLC.....K.....GN..QRPTQRSGl....yYSC..TNN.NITLLQVTKQYSGTYYGTNFNTEQ....DTYYSVKVLDP....................
A0A2L1F3C9_9ADEN/16-113             .......si--SSFDHKNITAYVGSNCVLT....GY...qSH...QR..VS......WY.WFDKKNTAYTLC.....K.....GY..HQPTQRGGl....yYSC..TNN.NITLLQVTKQYSGTYYGTNFNTKQ....DTYYSVEVLDP....................
B9A5K1_ADE08/110-200                .....rkpl----SEPHYVTVTMDHNITLV....GP....LN...LP..VT......WY.----DGEGNKFC.....D.....GE..KVEHAEFN......HTC..NIQ.NLTLLFVNLTHNGAYIGYTKDGSD....RELYEVSVKT-l...................
G8XT84_SCMVC/25-127                 ..rckhtwl---------INATVNTNVTLN....GTm.vlND...CS..IG......WY.--RNYGAYEPLC.....Q.....YD..ATKSDKMTtykkihYTC..QNS.SLIIFNVNRSASGEYFTYGHYH--....-----------ydcirekicykliill....
Q6QPD0_9ADEN/15-113                 .......al--CESVDRDVTITTGSNYTLK....GP....PS...GM..LS......WYcYFGTDTDQTELC.....N.....FQ..KGKTSNSKi...snYQC..NGT.DLILLNVTKAYGGSYYCPGQNTEE....MIFYKVEVVDP....................
W8CZR6_9ADEN/15-106                 ......yfs---QGNEQVVTLSLGDNYTLV....GP....QD...TP..VT......WY.---GGKGINKLC.....E.....GN..NVHFKQLK......HKC..NEQ.NLTLINVNKTYEAKYYGYRHDNTG....KKDFRIVVITP....................
Q9PX39_ADE07/13-100                 ........a-AVTYGRSHLTVPVGSTCTLQ....GP....QQ...GY..VT......WW.RIYDNGGFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITSNEQGFYYGTNYKD--....SLDYNIIVVP-a...................
Q9PX68_ADE07/13-104                 ........v-TVAHGQTIIHITLGHNHTLV....GP...pIT...SE..VI......WT.KLGSVDYFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSSSQ....YKNYLVRITQP....................
W8CZR6_9ADEN/219-302                .....gvvt------PIQVTINPGTNFTLV....GP....TD...VP..II......WY.----DNGLEDPC.....K.....DK..YKLR----......VEC..NEQ.NLTLINVNKTYETSFYGYGDKS-H....AKRYRVKVNT-t...................
B9A6H5_9ADEN/110-200                ........v-KPQPEPEYVFVYMGENKTLE....GP....PG...TP..VT......WF.----NQDGKKFC.....E.....GE..KVLHPEFN......HTC..DKQ.NLILLFVNFTHDGAYLGYNHQGTQ....RTHYEVTVLD-l...................
Q8BEL2_ADE04/22-115                 ...prvsfi-------KPVNVTEGSNVTLV....GV...eGA...KN..TT......WT.KYHLNGW-KDIC.....N.....WS..VTV-----......YTC..EGV.NLTIVNATSAQNGRIQGQSVSDSE....-----------gyytqhtfiydikvip....
Q7TFV8_RHCM6/30-134                 sskkitcip---------VNSTAGRNVTLN....PPpfnhHT...TY..VY......WY.R-QLGKGKNELC.....Ry..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN------....-----------ldlglgttsttcytltvkta
A0A0K1H002_9BETA/31-137             ...hkcskt-------ETRTGTVGTNITLV....TSpppnNK...GL..LY......WY.KPNC-TSNDRLC.....DysgftGN..NAVSNKTKl....kFSCmnNST.KLTLINVTAHYSGQYCSRTITSNG....S----------vdicfnvtihl.........
Q6QPD1_9ADEN/15-112                 .......ya--SGYANIQKTLYVGSDGTLE....GT...qSQ...AK..VA......WY.FYRTNTDPVKLC.....K.....GE..LPRTHKTPl....tFSC..SNN.NLTLFSITKQYTGTYYSTNFHTGQ....DKYYTVKVENP....................
A0A075IIG1_9ADEN/13-100             ........a-AVTYGRSHLTVPVGSTCTLQ....GP....QE...GY..VT......WW.RIYDNGGFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITLNEQGFYYGTNYKN--....SLDYNIIVVP-a...................
A0A0B4SHJ0_9ADEN/13-104             ........v-TVAHGQTIVHITLGHNHTLV....GP...pIT...SE..VI......WT.KLGSVDYFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSSSQ....YKNYLVRITQP....................
B9A5K1_ADE08/15-105                 ........a-FSQAGIINLNVLWGINLTLV....GP....LD...LP..VT......WY.----DKKGMQFC.....I.....GN..TIKNPQIK......HSC..DQQ.NLTLLNADKSHERTYLGYRHDSKG....KVDYKVTVIPP....................
B9A6H5_9ADEN/248-333                ......pat----IEAMLVTVTAGSNLTLV....GP...kAE...GK..VT......WF.----DGDLKRPC.....E.....PN..YRLR----......HEC..NNQ.NLTLINVTKDYEGTYYGTNDKD-E....GKRYRVKVNT-t...................
Q6QPC9_9ADEN/21-114                 ..itrvsfi-------KHVNVTEGDNITLA....GV...eGA...QN..TT......WT.KYHL-GW-RDIC.....T.....WN..VT------......YYC..IGV.NLTIVNANQSQNGLIKGQSVSVTS....DGYY-------tqhsfnynitvip.......
B9A6H5_9ADEN/15-105                 ........a-FSQAGFHTINATWWANITLV....GP....PD...TP..VT......WY.----DTQGLWFC.....N.....GS..RVKNPQIR......HTC..NDQ.NLTLIHVNKTYERTYMGYNRQGTK....KEDYKVVVIP-p...................
G8XT85_SCMVC/21-123                 .....hcsn----PGDIPISLKLGDNVTLN....GT...lQS...NH..ST......RY.WYHNETVLCKCT.....S.....GNpeTASGKKIT......FQC..HRNcSLTLINATVSHAGNYCVMNDFKDEnptlQLCYNVTI---lss.................
A0A2L1F3C8_9ADEN/22-115             ...prvsfi-------KLVNVTEGGNVILV....GV...eGA...KN..TT......WT.KYHLNGW-KNIC.....N.....WS..VTV-----......YTC..EGV.NLIIANATSAQNGRIQGQSVSDSN....-----------gyytqhtfiydikvip....
G8XT76_SCMVC/110-209                ...ndcycg--------SLTVPVGANFTLN....GT....QD...IDntIS.....qW-.-FYANTTRDLLCafwndN.....TN..YTM----Nhe.yvnYTC..TIE.HLLLLNLSTKNTGVYYNVKESVPE....HTNYTFI----cynl................
I3WEY5_9BETA/38-141                 ...faynvt--------HVSGYEHSNVTLH....TS...iSH...SN..IShmnvgyWI.RYNYPVNSYTIC.....T.....VS..GNNVASTKhn.gwfFEC..NGT.SLTLHNLNADHTGSYLFKNLLG-L....MEHYTVTVLP-i...................
W8CZR6_9ADEN/110-200                ......skv----PQTHNVFIKSGQNFTLH....GP....EY...TP..VQ......WF.---GGKKIVMLC.....D.....GS..TVHHKELK......HKC..NKQ.NITLIKVNQTFEGHYYGYSNDNTY....MEHYHVVVLN-s...................
#=GC seq_cons                       ........s.....t.p.lslshGsNhTLs....GP....ts...s...Vo......Wa.h...ssshpclC.....p.....ts..tsht..........apC..ssp.NLTLlNVopsasGpYhGhshpstp....ttpYplhV...h...................
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