#=GF ID Amidohydro_1
#=GF AC PF01979.24
#=GF DE Amidohydrolase family
#=GF PI Adenine_deam;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE Bateman A
#=GF GA 25.00 25.00;
#=GF TC 25.00 25.00;
#=GF NC 24.90 24.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0036
#=GF RN [1]
#=GF RM 9144792
#=GF RT An evolutionary treasure: unification of a broad set of
#=GF RT amidohydrolases related to urease.
#=GF RA Holm L, Sander C;
#=GF RL Proteins 1997;28:72-82.
#=GF RN [2]
#=GF RM 8550522
#=GF RT Role of adenine deaminase in purine salvage and nitrogen
#=GF RT metabolism and characterization of the ade gene in Bacillus
#=GF RT subtilis.
#=GF RA Nygaard P, Duckert P, Saxild HH;
#=GF RL J Bacteriol 1996;178:846-853.
#=GF RN [3]
#=GF RM 7754395
#=GF RT The crystal structure of urease from Klebsiella aerogenes.
#=GF RA Jabri E, Carr MB, Hausinger RP, Karplus PA;
#=GF RL Science 1995;268:998-1004.
#=GF RN [4]
#=GF RM 9878395
#=GF RT Novel organization and sequences of five genes encoding all six
#=GF RT enzymes for de novo pyrimidine biosynthesis in Trypanosoma
#=GF RT cruzi.
#=GF RA Gao G, Nara T, Nakajima-Shimada J, Aoki T;
#=GF RL J Mol Biol 1999;285:149-161.
#=GF RN [5]
#=GF RM 8590465
#=GF RT As in Saccharomyces cerevisiae, aspartate transcarbamoylase is
#=GF RT assembled on a multifunctional protein including a
#=GF RT dihydroorotase-like cryptic domain in Schizosaccharomyces pombe.
#=GF RA Lollier M, Jaquet L, Nedeva T, Lacroute F, Potier S, Souciet JL;
#=GF RL Curr Genet 1995;28:138-149.
#=GF DR INTERPRO; IPR006680;
#=GF DR MEROPS; M38;
#=GF DR SCOP; 1j79; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family of enzymes are a a large metal dependent hydrolase
#=GF CC superfamily [1]. The family includes Adenine deaminase
#=GF CC EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and
#=GF CC ammonia. Adenine deaminases reaction is important for adenine
#=GF CC utilisation as a purine and also as a nitrogen source [2]. This
#=GF CC family also includes dihydroorotase and
#=GF CC N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These
#=GF CC enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate
#=GF CC + H2O <=> D-glucosamine 6-phosphate + acetate. This family
#=GF CC includes the catalytic domain of urease alpha subunit [3].
#=GF CC Dihydroorotases (EC:3.5.2.3) are also included [4-5].
#=GF SQ 88651
#=GS A0A7Z0VTZ3_9ACTO/65-414 AC A0A7Z0VTZ3.1
#=GS Q3Z786_DEHM1/52-424 AC Q3Z786.1
#=GS A0A090T699_9VIBR/1-270 AC A0A090T699.1
#=GS A0A7I4DB43_PHYPA/1-293 AC A0A7I4DB43.1
#=GS A0A841TEG3_9BACL/58-407 AC A0A841TEG3.1
#=GS A0A4R5UBC2_9HYPH/51-440 AC A0A4R5UBC2.1
#=GS F8Q079_SERL3/71-476 AC F8Q079.1
#=GS A0A316U1A3_9BACT/348-443 AC A0A316U1A3.1
#=GS A0A841SNK2_9BACL/68-353 AC A0A841SNK2.1
#=GS A0A370GNS3_9NOCA/51-403 AC A0A370GNS3.1
#=GS A0A7X0BXM0_9ACTN/130-462 AC A0A7X0BXM0.1
#=GS A0A2K6F4H4_PROCO/74-448 AC A0A2K6F4H4.1
#=GS G4QIV9_GLANF/51-393 AC G4QIV9.1
#=GS A0A8J3HMD7_9ACTN/49-372 AC A0A8J3HMD7.1
#=GS A0A173M9A1_9BACT/86-423 AC A0A173M9A1.1
#=GS A0A4T0UW05_9ACTN/64-397 AC A0A4T0UW05.1
#=GS A0A1Y4HJX4_9BACT/51-381 AC A0A1Y4HJX4.1
#=GS A0A6S6G195_9SPHN/288-457 AC A0A6S6G195.1
#=GS A0A2I2GBX5_9EURO/347-516 AC A0A2I2GBX5.1
#=GS A0A5N5MZP6_9ROSI/94-466 AC A0A5N5MZP6.1
#=GS A0A5Q2N9C8_9FIRM/56-381 AC A0A5Q2N9C8.1
#=GS A0A088T3G8_9BACT/49-417 AC A0A088T3G8.1
#=GS A0A3P8UJ03_CYNSE/65-454 AC A0A3P8UJ03.1
#=GS A0A7L1VC03_SITEU/62-401 AC A0A7L1VC03.1
#=GS A0A7T4R0I2_9GAMM/125-458 AC A0A7T4R0I2.1
#=GS A0A4Y8PWD9_9BACL/54-424 AC A0A4Y8PWD9.1
#=GS A0A8J8FF71_9BACT/51-427 AC A0A8J8FF71.1
#=GS E2Q9H8_STRCL/132-460 AC E2Q9H8.1
#=GS R6C7R4_9CLOT/58-426 AC R6C7R4.1
#=GS A0A6P7XQN3_9AMPH/65-454 AC A0A6P7XQN3.1
#=GS A0A091B117_9GAMM/51-425 AC A0A091B117.1
#=GS A0A1I2N437_9SPHN/50-438 AC A0A1I2N437.1
#=GS A0A7X2H8T7_9BACL/52-422 AC A0A7X2H8T7.1
#=GS A0A8H7DCN2_9AGAR/1547-1670 AC A0A8H7DCN2.1
#=GS A0A1H2U4B9_9BACL/79-410 AC A0A1H2U4B9.1
#=GS ADEC2_DESPS/66-349 AC Q6ANH1.1
#=GS A0A366WL48_9GAMM/65-418 AC A0A366WL48.1
#=GS L8JTC4_9BACT/51-426 AC L8JTC4.1
#=GS A0A0C7N0L9_9SACH/272-527 AC A0A0C7N0L9.1
#=GS A0A1S3NKA6_SALSA/65-454 AC A0A1S3NKA6.1
#=GS T0I4F0_9SPHN/96-409 AC T0I4F0.1
#=GS A0A090IE49_9GAMM/59-401 AC A0A090IE49.1
#=GS A0A646KPU1_STRJU/60-387 AC A0A646KPU1.1
#=GS R9JVS3_9FIRM/59-425 AC R9JVS3.1
#=GS A0A5S9P5S4_MYCVN/183-371 AC A0A5S9P5S4.1
#=GS A0A6M5JE40_9SPHN/73-416 AC A0A6M5JE40.1
#=GS A0A1X1Y594_9MYCO/41-352 AC A0A1X1Y594.1
#=GS G3HBJ1_CRIGR/50-238 AC G3HBJ1.1
#=GS E8LJT3_SUCHY/50-427 AC E8LJT3.1
#=GS A0A2J8SUE7_PONAB/157-369 AC A0A2J8SUE7.1
#=GS A0A6V8KLB1_9ACTN/52-417 AC A0A6V8KLB1.1
#=GS A0A316ULZ2_9BASI/399-743 AC A0A316ULZ2.1
#=GS ADEC2_AGRFC/83-368 AC Q7CUX4.1
#=GS F6EME4_HOYSD/55-429 AC F6EME4.1
#=GS L1MFL6_9CORY/64-438 AC L1MFL6.1
#=GS A0A7K6A5Z3_ONYCO/73-432 AC A0A7K6A5Z3.1
#=GS A0A7K6MKE0_PANBI/1-83 AC A0A7K6MKE0.1
#=GS A0A6G9IF18_9GAMM/46-375 AC A0A6G9IF18.1
#=GS A0A5B9DIP6_9HYPH/64-445 AC A0A5B9DIP6.1
#=GS A0A8B9F5X4_9PSIT/57-450 AC A0A8B9F5X4.1
#=GS A0A4Q2UNU9_9BACT/50-390 AC A0A4Q2UNU9.1
#=GS A0A292E2A3_9HYPH/46-421 AC A0A292E2A3.1
#=GS B7K046_RIPO1/54-382 AC B7K046.1
#=GS A0A090T3M3_9VIBR/51-281 AC A0A090T3M3.1
#=GS H8MLH6_CORCM/49-435 AC H8MLH6.1
#=GS A0A8J2UHJ4_9BACT/85-440 AC A0A8J2UHJ4.1
#=GS PYRC_ALKEH/10-315 AC Q0AB36.1
#=GS A0A7N0UMH8_KALFE/52-385 AC A0A7N0UMH8.1
#=GS R7K4H1_9FIRM/46-414 AC R7K4H1.1
#=GS A0A8I6RHW5_CIMLE/85-455 AC A0A8I6RHW5.1
#=GS A0A6P1SXL8_9RHOB/47-431 AC A0A6P1SXL8.1
#=GS A0A1D2VBG5_9ASCO/109-551 AC A0A1D2VBG5.1
#=GS A0A371DJU2_9APHY/1170-1268 AC A0A371DJU2.1
#=GS A0A369XXT2_9FUSO/50-365 AC A0A369XXT2.1
#=GS A0A318KS08_9FIRM/49-384 AC A0A318KS08.1
#=GS G2TJU8_WEICA/50-420 AC G2TJU8.1
#=GS A0A255G8G6_9ACTN/29-362 AC A0A255G8G6.1
#=GS A0A5C6ABC3_9BACT/328-423 AC A0A5C6ABC3.1
#=GS A0A212KS37_9CHLA/67-405 AC A0A212KS37.1
#=GS A0A3M8LH94_9MICO/70-396 AC A0A3M8LH94.1
#=GS A0A8J7DW31_9CYAN/127-463 AC A0A8J7DW31.1
#=GS A0A518IXW3_9BACT/55-408 AC A0A518IXW3.1
#=GS A0A2K5SIR0_CEBIM/31-160 AC A0A2K5SIR0.1
#=GS C7RD01_KANKD/6-334 AC C7RD01.1
#=GS A0A1C4JZZ4_9ACTN/141-474 AC A0A1C4JZZ4.1
#=GS A0A135HTQ7_9HYPH/131-482 AC A0A135HTQ7.1
#=GS A0A1J6VU34_9BACI/58-390 AC A0A1J6VU34.1
#=GS A0A1M6A4C6_9ACTN/59-409 AC A0A1M6A4C6.1
#=GS A0A1T5A5T7_9SPHI/117-248 AC A0A1T5A5T7.1
#=GS R5WFR1_9BACT/36-359 AC R5WFR1.1
#=GS A0A163VM45_9HYPH/50-420 AC A0A163VM45.1
#=GS A0A1V0GU90_9RHOB/59-398 AC A0A1V0GU90.1
#=GS A0A4R2KKD9_9GAMM/107-479 AC A0A4R2KKD9.1
#=GS A0A4Z0YVJ6_9PEZI/53-195 AC A0A4Z0YVJ6.1
#=GS A0A1H7L799_9ACTN/55-404 AC A0A1H7L799.1
#=GS K0AYD0_GOTA9/48-391 AC K0AYD0.1
#=GS A0A1Y3UBF9_9ACTN/51-421 AC A0A1Y3UBF9.1
#=GS URE1_FRAAA/134-472 AC Q0RQS0.1
#=GS F7JQM4_9FIRM/70-393 AC F7JQM4.1
#=GS A0A8C3YK45_9CETA/178-567 AC A0A8C3YK45.1
#=GS A0A329R608_9ACTN/69-440 AC A0A329R608.1
#=GS A0A0Q6KK87_9SPHN/108-403 AC A0A0Q6KK87.1
#=GS A0A8J3GTE7_9RHOB/54-417 AC A0A8J3GTE7.1
#=GS A0A2P7SIF4_9HYPH/53-383 AC A0A2P7SIF4.1
#=GS A0A6P6BEU4_DURZI/395-724 AC A0A6P6BEU4.1
#=GS A0A810L645_9ACTN/47-437 AC A0A810L645.1
#=GS A0A1Y1RWT8_9SPIO/50-433 AC A0A1Y1RWT8.1
#=GS A0A6B2JXZ8_9RHOB/58-410 AC A0A6B2JXZ8.1
#=GS K8F3R7_9CHLO/109-417 AC K8F3R7.1
#=GS A0A5B0DTY2_9HYPH/60-391 AC A0A5B0DTY2.1
#=GS A0A8D0GUA5_SPHPU/63-452 AC A0A8D0GUA5.1
#=GS A0A124H7Z9_9ACTN/67-415 AC A0A124H7Z9.1
#=GS A0A498DVJ7_9ACTN/53-387 AC A0A498DVJ7.1
#=GS A0A1G7KAV6_9SPHI/52-387 AC A0A1G7KAV6.1
#=GS H4F385_9HYPH/50-442 AC H4F385.1
#=GS A0A0L0N0Y6_TOLOC/605-958 AC A0A0L0N0Y6.1
#=GS A0A0P7BQJ0_9HYPO/75-427 AC A0A0P7BQJ0.1
#=GS A0A7L5Y9W3_9BURK/64-429 AC A0A7L5Y9W3.1
#=GS A0A8H5TCY1_FUSHE/63-205 AC A0A8H5TCY1.1
#=GS A0A7J7AB20_9COLE/481-843 AC A0A7J7AB20.1
#=GS A0A1I3P2M1_9BACL/52-382 AC A0A1I3P2M1.1
#=GS A0A1H4M5L8_9MICC/54-436 AC A0A1H4M5L8.1
#=GS F7W433_SORMK/7-301 AC F7W433.1
#=GS A0A7M4EPS2_CROPO/125-514 AC A0A7M4EPS2.1
#=GS A0A5B9EGX3_9BACT/58-435 AC A0A5B9EGX3.1
#=GS A0A5E7YH82_9BACT/329-430 AC A0A5E7YH82.1
#=GS A0A7W8DY68_9BRAD/60-429 AC A0A7W8DY68.1
#=GS A0A8U0NB63_MUSPF/169-558 AC A0A8U0NB63.1
#=GS A0A4Q3LB51_9FLAO/379-712 AC A0A4Q3LB51.1
#=GS A0A5B8YKT5_9FLAO/831-937 AC A0A5B8YKT5.1
#=GS A0A840NJG1_9PSEU/46-412 AC A0A840NJG1.1
#=GS A0A5N1J539_9BACT/49-434 AC A0A5N1J539.1
#=GS A0A0Q8RWM0_9BURK/125-482 AC A0A0Q8RWM0.1
#=GS A0A4R5AE88_9ACTN/55-381 AC A0A4R5AE88.1
#=GS A0A1Y0ML74_9FLAO/700-1035 AC A0A1Y0ML74.1
#=GS A0A850D2X6_9ACTN/1-320 AC A0A850D2X6.1
#=GS K6DZP1_9BACI/50-420 AC K6DZP1.1
#=GS A0A2V1HQF9_9MICO/45-402 AC A0A2V1HQF9.1
#=GS A0A374DIK1_9FIRM/52-423 AC A0A374DIK1.1
#=GS A0A165CMT3_EXIGL/329-515 AC A0A165CMT3.1
#=GS U7PUZ2_SPOS1/75-228 AC U7PUZ2.1
#=GS A0A2N5XN55_9HYPH/77-362 AC A0A2N5XN55.1
#=GS E1M6H2_9STRE/49-380 AC E1M6H2.1
#=GS A0A4T0UP42_9NEIS/130-466 AC A0A4T0UP42.1
#=GS A0A1Y2EF79_9PEZI/237-407 AC A0A1Y2EF79.1
#=GS A0A7X2KEI7_9PROT/65-401 AC A0A7X2KEI7.1
#=GS A0A5N0VBL9_9PSEU/56-403 AC A0A5N0VBL9.1
#=GS K5XSW3_9PROT/73-354 AC K5XSW3.1
#=GS A0A238UPR3_9ACTN/47-415 AC A0A238UPR3.1
#=GS A0A1Z4L6C2_NOSLI/49-420 AC A0A1Z4L6C2.1
#=GS M7A6D7_9ACTN/71-469 AC M7A6D7.1
#=GS Q5SZC5_HUMAN/53-195 AC Q5SZC5.1
#=GS A0A1I4GPM3_9FIRM/54-400 AC A0A1I4GPM3.1
#=GS A0A072P4Q8_9EURO/9-342 AC A0A072P4Q8.1
#=GS A0A291LXT2_9RHOB/127-467 AC A0A291LXT2.1
#=GS A0A417N9I9_9FIRM/55-424 AC A0A417N9I9.1
#=GS A0A1V0GWH9_9RHOB/54-418 AC A0A1V0GWH9.1
#=GS PYRC_SHEPA/8-337 AC A8H7J4.1
#=GS A0A2A3GZ54_9ACTN/136-458 AC A0A2A3GZ54.1
#=GS A0A8C2UII2_COTJA/149-538 AC A0A8C2UII2.1
#=GS A0A255XYV1_9PROT/53-422 AC A0A255XYV1.1
#=GS A0A292Z546_9PSEU/37-392 AC A0A292Z546.1
#=GS A0A4R9EU89_9ACTN/64-430 AC A0A4R9EU89.1
#=GS A0A433UT39_ANAVA/127-464 AC A0A433UT39.1
#=GS A0A8J3HC70_9RHOB/50-442 AC A0A8J3HC70.1
#=GS A0A254QCJ7_9PROT/83-440 AC A0A254QCJ7.1
#=GS H1WDR0_9CYAN/64-433 AC H1WDR0.1
#=GS A0A1Y4I8U6_9FIRM/47-415 AC A0A1Y4I8U6.1
#=GS A0A2I2U844_FELCA/58-447 AC A0A2I2U844.2
#=GS A0A164TTW9_9AGAM/389-514 AC A0A164TTW9.1
#=GS A0A6S6XA89_9FIRM/54-395 AC A0A6S6XA89.1
#=GS A0A1H1D1T8_9MICC/58-388 AC A0A1H1D1T8.1
#=GS A0A1D8P5A6_9FLAO/227-415 AC A0A1D8P5A6.1
#=GS A0A554VLR2_9FLAO/74-441 AC A0A554VLR2.1
#=GS A0A067PIM9_9AGAM/323-527 AC A0A067PIM9.1
#=GS B9XKC1_PEDPL/865-964 AC B9XKC1.1
#=GS A0A7L1VP83_SITEU/52-441 AC A0A7L1VP83.1
#=GS A0A3N1AZA8_9ACTN/76-432 AC A0A3N1AZA8.1
#=GS A0A4S2L568_9HYME/1545-1875 AC A0A4S2L568.1
#=GS A0A316Z8Y2_9BASI/138-290 AC A0A316Z8Y2.1
#=GS A0A8C0VIT5_CYACU/34-424 AC A0A8C0VIT5.1
#=GS A0A673AAG7_9TELE/81-470 AC A0A673AAG7.1
#=GS A0A1H0I6X1_9PSEU/51-371 AC A0A1H0I6X1.1
#=GS A0A366M7Z1_9EURY/47-419 AC A0A366M7Z1.1
#=GS A0A1G9K0D1_9RHOB/48-431 AC A0A1G9K0D1.1
#=GS A0A4Y7TQ93_9AGAR/1048-1215 AC A0A4Y7TQ93.1
#=GS R5AXM1_9FIRM/41-400 AC R5AXM1.1
#=GS A0A839VHU4_9BURK/243-370 AC A0A839VHU4.1
#=GS A0A848HQU1_9BURK/721-1054 AC A0A848HQU1.1
#=GS A0A7K4WDP8_9TYRA/80-425 AC A0A7K4WDP8.1
#=GS A0A024UWJ6_9STRA/395-626 AC A0A024UWJ6.1
#=GS A0A1N7GRS1_9ACTN/55-392 AC A0A1N7GRS1.1
#=GS A0A2W7NJ17_9RHOB/55-405 AC A0A2W7NJ17.1
#=GS A0A4R3NCY1_9BACI/50-420 AC A0A4R3NCY1.1
#=GS A0A5C5X0I7_9PLAN/104-445 AC A0A5C5X0I7.1
#=GS A0A084JAB9_9CLOT/51-417 AC A0A084JAB9.1
#=GS A0A8E2JQD1_9PEZI/55-411 AC A0A8E2JQD1.1
#=GS A0A6H9YTT5_9ACTN/131-469 AC A0A6H9YTT5.1
#=GS A0A318AUV3_9CAUL/61-249 AC A0A318AUV3.1
#=GS A0A672P3J6_SINGR/65-448 AC A0A672P3J6.1
#=GS A0A0Q8RHB2_9BURK/65-421 AC A0A0Q8RHB2.1
#=GS A0A0D7BL07_9AGAR/317-496 AC A0A0D7BL07.1
#=GS A0A366EHP6_9BACI/51-421 AC A0A366EHP6.1
#=GS A0A8D0H5S7_SPHPU/78-423 AC A0A8D0H5S7.1
#=GS A0A1M6HP67_9RHOB/44-361 AC A0A1M6HP67.1
#=GS A0A3M0KPE7_HIRRU/60-449 AC A0A3M0KPE7.1
#=GS A0A0B0IDE7_9BACI/48-418 AC A0A0B0IDE7.1
#=GS A0A672PTU7_SINGR/312-450 AC A0A672PTU7.1
#=GS A0A5N6T5A5_ASPPS/63-418 AC A0A5N6T5A5.1
#=GS A0A7K9VSG6_9PASS/175-564 AC A0A7K9VSG6.1
#=GS A0A314XV88_PRUYE/100-479 AC A0A314XV88.1
#=GS A0A367B2U3_9ACTN/128-457 AC A0A367B2U3.1
#=GS A0A0P6VRT6_9HYPH/127-460 AC A0A0P6VRT6.1
#=GS K2M9R6_9HYPH/47-427 AC K2M9R6.1
#=GS A0A2N5X5J5_9GAMM/63-413 AC A0A2N5X5J5.1
#=GS A0A292YTQ9_9PSEU/57-439 AC A0A292YTQ9.1
#=GS A0A1G9ZFS3_9FIRM/51-421 AC A0A1G9ZFS3.1
#=GS A0A1C4IQW6_9ACTN/132-460 AC A0A1C4IQW6.1
#=GS A0A2A3JQB3_9RHOB/73-436 AC A0A2A3JQB3.1
#=GS A0A1R1MI12_9GAMM/50-437 AC A0A1R1MI12.1
#=GS A0A6J1J0C7_CUCMA/40-369 AC A0A6J1J0C7.1
#=GS A0A2T2N467_CORCC/56-455 AC A0A2T2N467.1
#=GS A0A4D9DFC0_9SAUR/1-136 AC A0A4D9DFC0.1
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