#=GF ID Ank
#=GF AC PF00023.34
#=GF DE Ankyrin repeat
#=GF PI ank;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Sonnhammer ELL;0000-0002-9015-5588
#=GF SE Swissprot_feature_table
#=GF GA 21.10 14.70;
#=GF TC 21.10 14.70;
#=GF NC 21.00 14.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Repeat
#=GF WK Ankyrin
#=GF WK Ankyrin_repeat
#=GF CL CL0465
#=GF RN [1]
#=GF RM 2141669
#=GF RT Hereditary spherocytosis associated with deletion of human
#=GF RT erythrocyte ankyrin gene on chromosome 8.
#=GF RA Lux SE, John KM, Bennett V;
#=GF RL Nature 1990;345:736-739.
#=GF RN [2]
#=GF RM 12456646
#=GF RT Crystal structure of a 12 ANK repeat stack from human ankyrinR.
#=GF RA Michaely P, Tomchick DR, Machius M, Anderson RG;
#=GF RL EMBO J. 2002;21:6387-6396.
#=GF RN [3]
#=GF RM 14731966
#=GF RT The ANK repeat: a ubiquitous motif involved in macromolecular
#=GF RT recognition.
#=GF RA Michaely P, Bennett V;
#=GF RL Trends Cell Biol. 1992;2:127-129.
#=GF DR INTERPRO; IPR002110;
#=GF DR SCOP; 1awc; fa;
#=GF DR MIM; 182900;
#=GF DC Hereditary spherocytosis
#=GF DR HOMSTRAD; ANK;
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC Ankyrins are multifunctional adaptors that link specific
#=GF CC proteins to the membrane-associated, spectrin- actin
#=GF CC cytoskeleton. This repeat-domain is a 'membrane-binding' domain
#=GF CC of up to 24 repeated units, and it mediates most of the
#=GF CC protein's binding activities. Repeats 13-24 are especially
#=GF CC active, with known sites of interaction for the Na/K ATPase,
#=GF CC Cl/HCO(3) anion exchanger, voltage-gated sodium channel,
#=GF CC clathrin heavy chain and L1 family cell adhesion molecules. The
#=GF CC ANK repeats are found to form a contiguous spiral stack such
#=GF CC that ion transporters like the anion exchanger associate in a
#=GF CC large central cavity formed by the ANK repeat spiral, while
#=GF CC clathrin and cell adhesion molecules associate with specific
#=GF CC regions outside this cavity [2][3].
#=GF SQ 63303
#=GS K3X2B5_GLOUD/103-134 AC K3X2B5.1
#=GS A0A1Q9DBA8_SYMMI/436-468 AC A0A1Q9DBA8.1
#=GS W7LUE4_GIBM7/327-359 AC W7LUE4.1
#=GS A0A250WPN0_9CHLO/19-51 AC A0A250WPN0.1
#=GS A0A6H5IXJ3_9HYME/288-323 AC A0A6H5IXJ3.1
#=GS A0A7J6GY39_CANSA/194-226 AC A0A7J6GY39.1
#=GS C5LJF6_PERM5/387-420 AC C5LJF6.1
#=GS A0A3B0KMK8_DROGU/269-300 AC A0A3B0KMK8.1
#=GS A0A834SND4_9FABA/39-71 AC A0A834SND4.1
#=GS NFKB1_CHICK/612-646 AC Q04861.2
#=GS A0A8H6F9Q7_9LECA/383-414 AC A0A8H6F9Q7.1
#=GS A0A1S2ZCE6_ERIEU/251-283 AC A0A1S2ZCE6.1
#=GS A0A6A1WQ48_9ROSI/97-128 AC A0A6A1WQ48.1
#=GS A0A251UI51_HELAN/131-161 AC A0A251UI51.1
#=GS A0A8H5JW05_9HYPO/385-417 AC A0A8H5JW05.1
#=GS A0A8C9KDL2_PANTA/128-169 AC A0A8C9KDL2.1
#=GS A0A2A4IU80_HELVI/254-285 AC A0A2A4IU80.1
#=GS A0A2J6PT25_9HELO/530-562 AC A0A2J6PT25.1
#=GS A0A7K9F949_STEPR/147-179 AC A0A7K9F949.1
#=GS A0A4W6BTK9_LATCA/223-253 AC A0A4W6BTK9.1
#=GS Q5CR22_CRYPI/222-257 AC Q5CR22.1
#=GS A0A0B1YTA6_9BURK/61-93 AC A0A0B1YTA6.1
#=GS A0A0D9R8J0_CHLSB/142-169 AC A0A0D9R8J0.1
#=GS G1XHX3_ARTOA/108-136 AC G1XHX3.1
#=GS A0A3P9A621_ESOLU/678-710 AC A0A3P9A621.2
#=GS A0A319DH93_9EURO/8-62 AC A0A319DH93.1
#=GS A0A813APU6_9DINO/787-818 AC A0A813APU6.1
#=GS A0A7L1PW65_ORIOR/10-37 AC A0A7L1PW65.1
#=GS A0A5N7DN43_9EURO/51-81 AC A0A5N7DN43.1
#=GS A0A2L2TW72_9HYPO/943-983 AC A0A2L2TW72.1
#=GS A0A319EDZ1_ASPSB/194-223 AC A0A319EDZ1.1
#=GS R1CIC6_EMIHU/174-205 AC R1CIC6.1
#=GS J3PAU9_GAET3/331-359 AC J3PAU9.1
#=GS A0A8D0KQU5_STROC/230-262 AC A0A8D0KQU5.1
#=GS A0A3Q3MDJ5_9TELE/514-544 AC A0A3Q3MDJ5.1
#=GS A0A3P7N1S8_CYLGO/58-90 AC A0A3P7N1S8.1
#=GS A0A7E6EN99_OCTVU/175-207 AC A0A7E6EN99.1
#=GS A0A7K9BKK0_DRONO/3-35 AC A0A7K9BKK0.1
#=GS A0A851LRL0_CORCR/40-71 AC A0A851LRL0.1
#=GS A0A1L9T2P5_9EURO/150-181 AC A0A1L9T2P5.1
#=GS A0A672T4N0_SINGR/428-455 AC A0A672T4N0.1
#=GS A0A091S2J6_NESNO/153-184 AC A0A091S2J6.1
#=GS A0A813BVY9_9DINO/246-276 AC A0A813BVY9.1
#=GS A0A1Y2GKJ9_9FUNG/329-361 AC A0A1Y2GKJ9.1
#=GS A0A8D0H317_SPHPU/39-72 AC A0A8D0H317.1
#=GS A0A7K7ZUD4_9PASE/143-172 AC A0A7K7ZUD4.1
#=GS A0A2A4IU80_HELVI/599-630 AC A0A2A4IU80.1
#=GS A0A814TVH9_9BILA/582-613 AC A0A814TVH9.1
#=GS A0A7J7CTR6_TRIWF/142-174 AC A0A7J7CTR6.1
#=GS A0A5J9T4V2_9POAL/106-136 AC A0A5J9T4V2.1
#=GS A0A2L2TKN5_9HYPO/1484-1513 AC A0A2L2TKN5.1
#=GS ANK3_RAT/605-637 AC O70511.3
#=GS A0A6P6GBN1_ZIZJJ/298-331 AC A0A6P6GBN1.1
#=GS A0A7L0RW10_GLABR/168-199 AC A0A7L0RW10.1
#=GS D7TLJ4_VITVI/237-269 AC D7TLJ4.1
#=GS A0A5J5BR29_9ASTE/175-201 AC A0A5J5BR29.1
#=GS A0A223NTS5_9SPHI/357-388 AC A0A223NTS5.1
#=GS A0A553N9Q6_TIGCA/625-655 AC A0A553N9Q6.1
#=GS A0A8B8X7I8_BALMU/145-176 AC A0A8B8X7I8.1
#=GS H2SQD5_TAKRU/179-209 AC H2SQD5.3
#=GS A0A0N1AL31_9SPHN/123-155 AC A0A0N1AL31.1
#=GS B4G829_DROPE/664-696 AC B4G829.1
#=GS V031_FOWPN/23-55 AC O90760.1
#=GS A0A093ZJC4_9PEZI/858-890 AC A0A093ZJC4.1
#=GS L9KI88_TUPCH/103-134 AC L9KI88.1
#=GS A0A2G5E735_AQUCA/19-48 AC A0A2G5E735.1
#=GS A0A0C3GHM7_9PEZI/27-57 AC A0A0C3GHM7.1
#=GS W3X230_PESFW/346-378 AC W3X230.1
#=GS A0A8H5YQ53_9HYPO/932-970 AC A0A8H5YQ53.1
#=GS A0A8C3QR00_9PASS/227-258 AC A0A8C3QR00.1
#=GS A0A430QIC5_SCHBO/126-155 AC A0A430QIC5.1
#=GS A0A2U3VWE5_ODORO/142-169 AC A0A2U3VWE5.1
#=GS E3MI70_CAERE/309-342 AC E3MI70.1
#=GS N4UR97_FUSC1/1011-1041 AC N4UR97.1
#=GS A0A8H4XNG9_9HYPO/621-652 AC A0A8H4XNG9.1
#=GS A0A2J8UWC2_PONAB/174-206 AC A0A2J8UWC2.1
#=GS A0A7K4KDG4_9AVES/142-169 AC A0A7K4KDG4.1
#=GS A0A0V1N5I9_9BILA/290-322 AC A0A0V1N5I9.1
#=GS A0A8B8W3Y0_BALMU/290-323 AC A0A8B8W3Y0.1
#=GS A0A6A5FND7_PERFL/184-216 AC A0A6A5FND7.1
#=GS A0A267EWG0_9PLAT/34-66 AC A0A267EWG0.1
#=GS A0A5N5LRB7_9ROSI/39-71 AC A0A5N5LRB7.1
#=GS A0A6J1PZ73_9HYME/573-605 AC A0A6J1PZ73.1
#=GS A0A1R2BEM7_9CILI/158-190 AC A0A1R2BEM7.1
#=GS A0A8C9YZB1_SANLU/104-135 AC A0A8C9YZB1.1
#=GS A0A6P5BK23_BOSIN/192-222 AC A0A6P5BK23.1
#=GS A0A6I9NZE0_9TELE/25-56 AC A0A6I9NZE0.1
#=GS U5DLK8_9CHRO/257-286 AC U5DLK8.1
#=GS A0A7K4XGQ2_REGSA/181-213 AC A0A7K4XGQ2.1
#=GS A0A0R0JT14_SOYBN/148-177 AC A0A0R0JT14.1
#=GS W2S823_9EURO/18-45 AC W2S823.1
#=GS VC17_VACCC/59-94 AC P21101.1
#=GS A0A8B7B6C4_ORYAF/142-171 AC A0A8B7B6C4.1
#=GS A0A2K6GAI2_PROCO/291-319 AC A0A2K6GAI2.1
#=GS A0A6J0YUR6_ODOVR/200-230 AC A0A6J0YUR6.1
#=GS A0A8B9C7G1_9AVES/266-297 AC A0A8B9C7G1.1
#=GS A0A8H5NYH5_GIBSU/105-138 AC A0A8H5NYH5.1
#=GS B6Q4B7_TALMQ/1166-1198 AC B6Q4B7.1
#=GS A0A8C3GJB0_CAIMO/142-171 AC A0A8C3GJB0.1
#=GS S9WQW7_CAMFR/288-319 AC S9WQW7.1
#=GS A0A813QUF8_ADIRI/389-413 AC A0A813QUF8.1
#=GS A0A2T2MZT3_CORCC/488-514 AC A0A2T2MZT3.1
#=GS A0A314ZYI9_PRUYE/195-227 AC A0A314ZYI9.1
#=GS A0A1Q9CW58_SYMMI/594-626 AC A0A1Q9CW58.1
#=GS A0A1Q9BXD6_SYMMI/92-120 AC A0A1Q9BXD6.1
#=GS D2VLR3_NAEGR/49-82 AC D2VLR3.1
#=GS A0A287B555_PIG/484-517 AC A0A287B555.1
#=GS A0A3Q2ZX13_KRYMA/931-961 AC A0A3Q2ZX13.1
#=GS A0A395N3K9_9HYPO/561-591 AC A0A395N3K9.1
#=GS A0A167UDK6_9AGAM/94-123 AC A0A167UDK6.1
#=GS A0A8C7DBW1_ONCKI/508-539 AC A0A8C7DBW1.1
#=GS A0A1E4TJE1_9ASCO/479-511 AC A0A1E4TJE1.1
#=GS A0A668T6G9_OREAU/1709-1741 AC A0A668T6G9.1
#=GS A0A673HRX6_9TELE/301-329 AC A0A673HRX6.1
#=GS A0A3R7K9X8_9STRA/9-41 AC A0A3R7K9X8.1
#=GS A0A098DNL4_GIBZE/689-718 AC A0A098DNL4.1
#=GS A0A6F9CVM8_9TELE/512-545 AC A0A6F9CVM8.1
#=GS A0A8C3LLT2_CHRPC/362-392 AC A0A8C3LLT2.1
#=GS A0A812PEX1_9DINO/426-455 AC A0A812PEX1.1
#=GS A0A8C4W7F7_9SAUR/548-580 AC A0A8C4W7F7.1
#=GS ABTB2_RAT/606-635 AC O08764.1
#=GS A0A6J2X608_SITOR/252-283 AC A0A6J2X608.1
#=GS A0A672JAU3_SALFA/212-248 AC A0A672JAU3.1
#=GS A0A7M7LNA6_NASVI/191-224 AC A0A7M7LNA6.1
#=GS A0A0S3S8N5_PHAAN/185-220 AC A0A0S3S8N5.1
#=GS ANR28_HUMAN/652-684 AC O15084.5
#=GS A0A7K4WKW3_9TYRA/542-575 AC A0A7K4WKW3.1
#=GS A0A8C4I0D2_DICLA/563-593 AC A0A8C4I0D2.2
#=GS A0A7L1KRA4_HIMHI/851-883 AC A0A7L1KRA4.1
#=GS A0A6J0K149_RAPSA/195-227 AC A0A6J0K149.1
#=GS A0A0N5DA05_THECL/299-331 AC A0A0N5DA05.1
#=GS A0A8H5GPI2_9AGAR/194-226 AC A0A8H5GPI2.1
#=GS A0A7N5KKZ1_AILME/250-282 AC A0A7N5KKZ1.1
#=GS A0A8H7X585_9HELO/217-247 AC A0A8H7X585.1
#=GS A0A0F9XS34_TRIHA/1430-1460 AC A0A0F9XS34.1
#=GS A0A1S3AHJ8_ERIEU/139-171 AC A0A1S3AHJ8.1
#=GS M4DLK4_BRARP/186-218 AC M4DLK4.1
#=GS A0A8C9EB12_PHOSS/106-137 AC A0A8C9EB12.1
#=GS A0A814CRV1_ADIRI/47-79 AC A0A814CRV1.1
#=GS A0A8J1VUE8_9TREE/1150-1182 AC A0A8J1VUE8.1
#=GS A0A1I4RVF1_9BACL/58-88 AC A0A1I4RVF1.1
#=GS A2DR45_TRIV3/265-297 AC A2DR45.1
#=GS H2ZD11_CIOSA/77-102 AC H2ZD11.1
#=GS A0A2K6FD06_PROCO/261-294 AC A0A2K6FD06.1
#=GS V9FID5_PHYPR/36-67 AC V9FID5.1
#=GS A0A6J2YHD2_SITOR/213-244 AC A0A6J2YHD2.1
#=GS A0A674JTT5_TERCA/598-629 AC A0A674JTT5.1
#=GS A0A812G137_9DINO/96-128 AC A0A812G137.1
#=GS A0A6A3FEK0_9STRA/36-74 AC A0A6A3FEK0.1
#=GS A0A6P3I0V1_BISBI/414-446 AC A0A6P3I0V1.1
#=GS D0P4W1_PHYIT/125-157 AC D0P4W1.1
#=GS A0A176WH45_MARPO/44-77 AC A0A176WH45.1
#=GS A0A0D1XI75_9PEZI/152-182 AC A0A0D1XI75.1
#=GS A0A8J5S2X9_ZIZPA/196-227 AC A0A8J5S2X9.1
#=GS A0A6F9BTT1_9TELE/86-118 AC A0A6F9BTT1.1
#=GS A0A8C5GHS4_9TELE/142-169 AC A0A8C5GHS4.1
#=GS A0A2N5VUX2_9BASI/631-663 AC A0A2N5VUX2.1
#=GS A0A1U7R5B6_MESAU/57-92 AC A0A1U7R5B6.1
#=GS A0A8C5H3U4_9TELE/217-249 AC A0A8C5H3U4.1
#=GS A0A4Z0Y341_9PEZI/116-145 AC A0A4Z0Y341.1
#=GS A0A0W1AJJ4_9GAMM/161-192 AC A0A0W1AJJ4.1
#=GS A0A2K5EAK0_AOTNA/160-191 AC A0A2K5EAK0.1
#=GS A0A2H5QCA1_CITUN/94-126 AC A0A2H5QCA1.1
#=GS A0A814SAF8_9BILA/62-93 AC A0A814SAF8.1
#=GS A0A0U5C3I2_ASPCI/316-346 AC A0A0U5C3I2.1
#=GS A0A669QGM9_PHACC/117-149 AC A0A669QGM9.1
#=GS A0A668SN35_OREAU/45-75 AC A0A668SN35.1
#=GS A0A484FGG6_COLOR/58-89 AC A0A484FGG6.1
#=GS A0A674HF98_TAEGU/336-368 AC A0A674HF98.1
#=GS A0A834IIB8_RHYFE/82-112 AC A0A834IIB8.1
#=GS A0A8E0RS83_9TREM/109-141 AC A0A8E0RS83.1
#=GS N1RZ45_FUSC4/437-467 AC N1RZ45.1
#=GS A7EW32_SCLS1/333-362 AC A7EW32.1
#=GS A0A7L1B2P2_GYMTI/344-376 AC A0A7L1B2P2.1
#=GS W9VXB9_9EURO/688-721 AC W9VXB9.1
#=GS A0A8C7DXQ9_ONCKI/438-470 AC A0A8C7DXQ9.1
#=GS A0A7M7PD70_STRPU/741-773 AC A0A7M7PD70.1
#=GS A0A835F1G5_9POAL/196-227 AC A0A835F1G5.1
#=GS A0A836BNS9_9CHLO/227-257 AC A0A836BNS9.1
#=GS A0A504YRT3_FASGI/109-141 AC A0A504YRT3.1
#=GS A0A7L2CN27_CATFU/344-376 AC A0A7L2CN27.1
#=GS A0A7J6VS84_THATH/214-245 AC A0A7J6VS84.1
#=GS A0A670JUY0_PODMU/163-195 AC A0A670JUY0.1
#=GS A0A7K6QMG4_9PASS/142-169 AC A0A7K6QMG4.1
#=GS A0A8B7XZJ0_ACAPL/128-160 AC A0A8B7XZJ0.1
#=GS A0A452HEW3_9SAUR/74-107 AC A0A452HEW3.1
#=GS A0A8H4GX56_9EURO/1396-1427 AC A0A8H4GX56.1
#=GS AKR1_SCHPO/33-64 AC Q09701.1
#=GS A0A7L1PSX0_ORIOR/262-295 AC A0A7L1PSX0.1
#=GS A0A812LR56_9DINO/41-73 AC A0A812LR56.1
#=GS A0A673T109_SURSU/186-215 AC A0A673T109.1
#=GS A0A2S6CNE0_9PEZI/10-38 AC A0A2S6CNE0.1
#=GS A0A444SNZ2_ARMVU/425-454 AC A0A444SNZ2.1
#=GS E1ZNM2_CHLVA/62-97 AC E1ZNM2.1
#=GS A0A8J6KCW6_ELECQ/104-135 AC A0A8J6KCW6.1
#=GS W5KB05_ASTMX/217-249 AC W5KB05.2
#=GS A0A091LVG3_CATAU/700-732 AC A0A091LVG3.1
#=GS S2K5U3_MUCC1/485-517 AC S2K5U3.1
#=GS A0A821H1C5_9BILA/199-230 AC A0A821H1C5.1
#=GS A0A6P5X3K2_DURZI/69-101 AC A0A6P5X3K2.1
#=GS A0A8C9HRJ4_9PRIM/142-171 AC A0A8C9HRJ4.1
#=GS M1WCR3_CLAP2/106-135 AC M1WCR3.1
#=GS Q6VZ44_CNPV/36-68 AC Q6VZ44.1
#=GS A0A094FPC6_9PEZI/752-783 AC A0A094FPC6.1
#=GS A0A1B8AZK0_FUSPO/713-751 AC A0A1B8AZK0.1
#=GS L2FFV1_COLFN/169-200 AC L2FFV1.1
#=GS A0A8C0I9Q6_BUBBB/174-207 AC A0A8C0I9Q6.1
#=GS Q5JYL1_HUMAN/1-23 AC Q5JYL1.8
#=GS A7RTX2_NEMVE/141-174 AC A7RTX2.1
#=GS A0A067L722_JATCU/195-227 AC A0A067L722.1
#=GS A0A674IT78_TERCA/198-230 AC A0A674IT78.1
#=GS A0A437BB74_CHISP/29-61 AC A0A437BB74.1
#=GS A0A812XDV7_9DINO/66-99 AC A0A812XDV7.1
#=GS B7PND3_IXOSC/116-148 AC B7PND3.1
#=GS A0A8C5V000_MICMU/161-193 AC A0A8C5V000.1
#=GS C7Z7C8_FUSV7/166-196 AC C7Z7C8.1
#=GS A0A3Q3XLC4_MOLML/159-191 AC A0A3Q3XLC4.1
#=GS A0A5N4E8J9_CAMDR/11-37 AC A0A5N4E8J9.1
#=GS A0A098G8Z6_9GAMM/138-167 AC A0A098G8Z6.1
#=GS A0A674JNV3_TERCA/132-162 AC A0A674JNV3.1
#=GS A0A059CMX5_EUCGR/173-205 AC A0A059CMX5.1
#=GS A0A7L4M2Q9_GLAPT/129-161 AC A0A7L4M2Q9.1
#=GS H3DEM8_TETNG/239-271 AC H3DEM8.1
#=GS A0A7J7AS92_9COLE/812-843 AC A0A7J7AS92.1
#=GS A0A2I3S605_PANTR/142-171 AC A0A2I3S605.1
#=GS A0A2J8XLS7_PONAB/140-170 AC A0A2J8XLS7.1
#=GS L8GWJ4_ACACA/203-235 AC L8GWJ4.1
#=GS A0A498JZE9_MALDO/80-112 AC A0A498JZE9.1
#=GS A0A7L3KL15_9PASS/226-258 AC A0A7L3KL15.1
#=GS A0A8R2DM11_BOMMO/1102-1134 AC A0A8R2DM11.1
#=GS A0A6H5HU00_9HYME/232-263 AC A0A6H5HU00.1
#=GS A0A7L2ZZ63_9PASE/177-206 AC A0A7L2ZZ63.1
#=GS A0A370TZR4_9HELO/276-308 AC A0A370TZR4.1
#=GS A0A2P4X5D8_9STRA/56-91 AC A0A2P4X5D8.1
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