GenomeNet

Database: Pfam
Entry: Apelin
LinkDB: Apelin
Original site: Apelin 
#=GF ID   Apelin
#=GF AC   PF15360.9
#=GF DE   APJ endogenous ligand
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q9ULZ1
#=GF GA   27.00 27.00;
#=GF TC   33.70 33.30;
#=GF NC   23.10 22.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11250876
#=GF RT   [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing
#=GF RT   the APJ orphan receptor in human and rat tissues with evidence
#=GF RT   for a vasoconstrictor role in man.
#=GF RA   Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP;
#=GF RL   Br J Pharmacol. 2001;132:1255-1260.
#=GF RN   [2]
#=GF RM   12963638
#=GF RT   Novel role for the potent endogenous inotrope apelin in human
#=GF RT   cardiac dysfunction.
#=GF RA   Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R,
#=GF RA   Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R,
#=GF RA   Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS,
#=GF RA   Quertermous T;
#=GF RL   Circulation. 2003;108:1432-1439.
#=GF RN   [3]
#=GF RM   22842084
#=GF RT   Apelin inhibits adipogenesis and lipolysis through distinct
#=GF RT   molecular pathways.
#=GF RA   Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen
#=GF RA   P;
#=GF RL   Mol Cell Endocrinol. 2012; [Epub ahead of print]
#=GF RN   [4]
#=GF RM   22895257
#=GF RT   INHIBITION OF APELIN EXPRESSION BY BMP SIGNALING IN ENDOTHELIAL
#=GF RT   CELLS.
#=GF RA   Poirier O, Ciumas M, Eyries M, Montagne K, Nadaud S, Soubrier F;
#=GF RL   Am J Physiol Cell Physiol. 2012; [Epub ahead of print]
#=GF DR   INTERPRO; IPR026155;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Apelin is among the most potent stimulators of cardiac
#=GF CC   contractility known. The apelin-APJ signaling pathway is an
#=GF CC   important novel mediator of cardiovascular control [1]. Apelin
#=GF CC   is an adipokine secreted by adipocytes where it is co-expressed
#=GF CC   with apelin receptor (APJ) in adipocytes.  It suppresses
#=GF CC   adipogenesis through MAPK kinase/ERK dependent pathways and
#=GF CC   prevents lipid droplet fragmentation, thereby inhibiting basal
#=GF CC   lipolysis through AMP kinase dependent enhancement of perilipin
#=GF CC   expression. It also inhibits hormone-stimulated acute lipolysis
#=GF CC   through decreasing perilipin phosphorylation. Apelin induces a
#=GF CC   decrease of free fatty acid release via its dual inhibition on
#=GF CC   adipogenesis and lipolysis [2]. As a vaso-active and vascular
#=GF CC   cell growth-regulating peptide Apelin is a target of the BMP
#=GF CC   pathway, the TGF-beta/bone morphogenic protein (BMP) system - a
#=GF CC   major pathway for angiogenesis [3].
#=GF SQ   142
#=GS A0A3Q3GVJ4_9LABR/22-76    AC A0A3Q3GVJ4.1
#=GS A0A6I9MGS3_PERMB/23-77    AC A0A6I9MGS3.1
#=GS A0A553P983_9TELE/15-69    AC A0A553P983.1
#=GS A0A452DJT3_BOVIN/136-190  AC A0A452DJT3.1
#=GS A0A6P3F8X9_OCTDE/23-77    AC A0A6P3F8X9.1
#=GS A0A6J3GF65_SAPAP/23-77    AC A0A6J3GF65.1
#=GS A0A2Y9SZ03_PHYMC/23-77    AC A0A2Y9SZ03.1
#=GS G1TTT0_RABIT/23-77        AC G1TTT0.1
#=GS A1XP38_XENLA/23-76        AC A1XP38.1
#=GS A0A6P3GHG1_BISBI/22-76    AC A0A6P3GHG1.1
#=GS A0A6I8PRH6_ORNAN/20-74    AC A0A6I8PRH6.1
#=GS A0A2Y9KMF0_ENHLU/23-77    AC A0A2Y9KMF0.1
#=GS A0A4W6FVM6_LATCA/28-82    AC A0A4W6FVM6.1
#=GS A0A6J1YXY3_ACIJB/23-77    AC A0A6J1YXY3.1
#=GS A0A2I2Z1U0_GORGO/23-77    AC A0A2I2Z1U0.1
#=GS A0A3B5KED7_TAKRU/111-165  AC A0A3B5KED7.1
#=GS A0A3P9AED5_ESOLU/28-83    AC A0A3P9AED5.2
#=GS A0A2Y9GQL4_NEOSC/23-77    AC A0A2Y9GQL4.1
#=GS W5PZT7_SHEEP/22-76        AC W5PZT7.1
#=GS A0A6P8UPF5_GYMAC/23-77    AC A0A6P8UPF5.1
#=GS A0A3Q3W1A2_MOLML/22-76    AC A0A3Q3W1A2.1
#=GS A0A6J2QF47_COTGO/23-77    AC A0A6J2QF47.1
#=GS A0A4W5N3B3_9TELE/16-70    AC A0A4W5N3B3.1
#=GS A0A484CWX4_PERFV/23-60    AC A0A484CWX4.1
#=GS A0A4D9DYI7_9SAUR/70-124   AC A0A4D9DYI7.1
#=GS A0A452EV17_CAPHI/12-66    AC A0A452EV17.1
#=GS A0A669EFW3_ORENI/21-75    AC A0A669EFW3.1
#=GS A0A3N0Z006_ANAGA/1-54     AC A0A3N0Z006.1
#=GS A0A3Q2ZEC5_KRYMA/22-74    AC A0A3Q2ZEC5.1
#=GS APEL_MOUSE/23-77          AC Q9R0R4.1
#=GS A0A452EUY8_CAPHI/18-72    AC A0A452EUY8.1
#=GS A0A6G1PUX7_9TELE/23-77    AC A0A6G1PUX7.1
#=GS A0A3Q7XFM5_URSAR/23-77    AC A0A3Q7XFM5.1
#=GS A0A5G2R3Z5_PIG/23-77      AC A0A5G2R3Z5.1
#=GS A0A6J2MI34_9CHIR/23-77    AC A0A6J2MI34.1
#=GS A0A671DPD8_RHIFE/23-77    AC A0A671DPD8.1
#=GS A0A1U7SBI1_ALLSI/9-63     AC A0A1U7SBI1.1
#=GS A0A6I9JN85_CHRAS/26-78    AC A0A6I9JN85.1
#=GS A0A663EI76_AQUCH/21-75    AC A0A663EI76.1
#=GS A0A3P8UVQ3_CYNSE/22-76    AC A0A3P8UVQ3.1
#=GS A0A667ZSA2_9TELE/25-79    AC A0A667ZSA2.1
#=GS A0A5N5NXA0_PANHP/23-77    AC A0A5N5NXA0.1
#=GS A0A1U7TII0_CARSF/23-77    AC A0A1U7TII0.1
#=GS A0A3Q2FIY1_CYPVA/22-74    AC A0A3Q2FIY1.1
#=GS A0A2K5Y1Q5_MANLE/23-77    AC A0A2K5Y1Q5.1
#=GS A0A668W199_OREAU/21-75    AC A0A668W199.1
#=GS A0A671N367_9TELE/116-170  AC A0A671N367.1
#=GS A0A6P7J6L8_9TELE/23-77    AC A0A6P7J6L8.1
#=GS A0A3Q7UL60_VULVU/70-124   AC A0A3Q7UL60.1
#=GS A0A7F8QY06_LEPWE/87-141   AC A0A7F8QY06.1
#=GS A0A452RG05_URSAM/17-71    AC A0A452RG05.1
#=GS A0A670K5A7_PODMU/20-74    AC A0A670K5A7.1
#=GS A0A384CGN6_URSMA/24-78    AC A0A384CGN6.1
#=GS A0A7N6B6F2_ANATE/111-165  AC A0A7N6B6F2.1
#=GS G1Q652_MYOLU/23-77        AC G1Q652.1
#=GS A0A3P8S8N4_AMPPE/115-169  AC A0A3P8S8N4.1
#=GS A0A2K5QLE1_CEBIM/23-77    AC A0A2K5QLE1.1
#=GS A0A2I4AW38_9TELE/23-75    AC A0A2I4AW38.1
#=GS A9ULR5_XENTR/23-76        AC A9ULR5.1
#=GS A0A452GLA3_9SAUR/24-75    AC A0A452GLA3.1
#=GS A0A2K6KLP8_RHIBE/23-77    AC A0A2K6KLP8.1
#=GS A0A4W5RII3_9TELE/28-83    AC A0A4W5RII3.1
#=GS A0A673WH90_SALTR/18-73    AC A0A673WH90.1
#=GS A0A3Q7MMP1_CALUR/23-77    AC A0A3Q7MMP1.1
#=GS A0A1S3A126_ERIEU/23-77    AC A0A1S3A126.1
#=GS A0A5F4CM34_CANLF/146-200  AC A0A5F4CM34.1
#=GS A0A3Q2HT60_HORSE/132-186  AC A0A3Q2HT60.1
#=GS A0A3Q1CW32_AMPOC/23-77    AC A0A3Q1CW32.1
#=GS A0A498LPD1_LABRO/23-77    AC A0A498LPD1.1
#=GS A0A6I9NQB0_9TELE/23-77    AC A0A6I9NQB0.1
#=GS A0A3B1J5L3_ASTMX/277-331  AC A0A3B1J5L3.1
#=GS A0A2K6TVK2_SAIBB/23-77    AC A0A2K6TVK2.1
#=GS F7EWH6_MONDO/151-204      AC F7EWH6.2
#=GS A0A674G8Y2_TAEGU/19-72    AC A0A674G8Y2.1
#=GS A0A6P7YN13_9AMPH/23-77    AC A0A6P7YN13.1
#=GS A0A1S3SSH3_SALSA/23-78    AC A0A1S3SSH3.1
#=GS A0A671WAG3_SPAAU/30-84    AC A0A671WAG3.1
#=GS A0A2K6B2K3_MACNE/23-77    AC A0A2K6B2K3.1
#=GS A0A3P9BJI6_9CICH/22-76    AC A0A3P9BJI6.1
#=GS A0A669PRG7_PHACC/24-78    AC A0A669PRG7.1
#=GS W5NDT8_LEPOC/23-77        AC W5NDT8.1
#=GS A0A4V6ANC4_COLLU/67-121   AC A0A4V6ANC4.1
#=GS G3U153_LOXAF/23-77        AC G3U153.1
#=GS APEL_HUMAN/23-77          AC Q9ULZ1.1
#=GS A0A7N8Y2E8_9TELE/7-61     AC A0A7N8Y2E8.1
#=GS A0A6P5ITS1_PHACI/23-76    AC A0A6P5ITS1.1
#=GS A0A5N3XG03_MUNRE/18-72    AC A0A5N3XG03.1
#=GS A0A673CYF0_9TELE/107-161  AC A0A673CYF0.1
#=GS A0A672K9E7_SINGR/12-66    AC A0A672K9E7.1
#=GS A0A673LNB8_9TELE/132-186  AC A0A673LNB8.1
#=GS A0A6P6IPL8_PUMCO/23-77    AC A0A6P6IPL8.1
#=GS A0A671PZY5_9TELE/23-77    AC A0A671PZY5.1
#=GS A0A485NZH6_LYNPA/8-62     AC A0A485NZH6.1
#=GS A0A337S4B6_FELCA/23-77    AC A0A337S4B6.1
#=GS APEL_RAT/23-77            AC Q9R0R3.1
#=GS A0A4W4FZJ5_ELEEL/173-227  AC A0A4W4FZJ5.1
#=GS A0A6P3VLL1_CLUHA/23-77    AC A0A6P3VLL1.1
#=GS A0A556V0T9_BAGYA/23-77    AC A0A556V0T9.1
#=GS A0A7N5K9G0_AILME/156-210  AC A0A7N5K9G0.1
#=GS A0A6J3A312_VICPA/9-63     AC A0A6J3A312.1
#=GS A0A2K5IYX0_COLAP/23-77    AC A0A2K5IYX0.1
#=GS A0A6P6LAE1_CARAU/48-102   AC A0A6P6LAE1.1
#=GS A0A2U9CAC4_SCOMX/23-57    AC A0A2U9CAC4.1
#=GS A0A2K6EG20_PROCO/23-77    AC A0A2K6EG20.1
#=GS M4AGL4_XIPMA/22-74        AC M4AGL4.2
#=GS A0A673ZU53_SALTR/15-70    AC A0A673ZU53.1
#=GS A0A672T4Q1_SINGR/125-179  AC A0A672T4Q1.1
#=GS A0A2K6RR72_RHIRO/23-77    AC A0A2K6RR72.1
#=GS A0A4W3HLR3_CALMI/20-72    AC A0A4W3HLR3.1
#=GS A0A5E4CPB6_MARMO/23-75    AC A0A5E4CPB6.1
#=GS A0A6P5B4Y6_BOSIN/23-77    AC A0A6P5B4Y6.1
#=GS A0A3Q4N6C1_NEOBR/22-76    AC A0A3Q4N6C1.1
#=GS W5PZT6_SHEEP/28-82        AC W5PZT6.1
#=GS A0A493T7U4_ANAPP/25-76    AC A0A493T7U4.1
#=GS A0A1L7HA09_CHICK/24-78    AC A0A1L7HA09.1
#=GS APEL_BOVIN/23-77          AC Q9TUI9.1
#=GS A0A6P3RLY6_PTEVA/23-77    AC A0A6P3RLY6.1
#=GS A0A286XKG6_CAVPO/23-75    AC A0A286XKG6.1
#=GS A0A1S3FAK0_DIPOR/23-77    AC A0A1S3FAK0.1
#=GS A0A1U7R0D2_MESAU/23-77    AC A0A1U7R0D2.1
#=GS A0A670YC81_PSETE/17-71    AC A0A670YC81.1
#=GS A0A673KQE5_9TELE/13-59    AC A0A673KQE5.1
#=GS A0A672JE25_SALFA/121-175  AC A0A672JE25.1
#=GS A0A665UGS1_ECHNA/31-83    AC A0A665UGS1.1
#=GS A0A3P9P6G2_POERE/22-74    AC A0A3P9P6G2.1
#=GS A0A6P7NT53_BETSP/23-77    AC A0A6P7NT53.1
#=GS A0A0D9R7Q2_CHLSB/23-77    AC A0A0D9R7Q2.1
#=GS A0A4X2JTI2_VOMUR/23-76    AC A0A4X2JTI2.1
#=GS A0A6J3DSQ2_AYTFU/24-75    AC A0A6J3DSQ2.1
#=GS A0A3B3IPB5_ORYLA/22-76    AC A0A3B3IPB5.1
#=GS A0A3Q3C5Y7_HAPBU/22-76    AC A0A3Q3C5Y7.1
#=GS A0A287D3D8_ICTTR/23-75    AC A0A287D3D8.1
#=GS A0A2U3VXS2_ODORO/23-77    AC A0A2U3VXS2.1
#=GS APEL_DANRE/23-77          AC Q4TTN8.2
#=GS A0A674IVS8_TERCA/7-61     AC A0A674IVS8.1
#=GS A0A6J2URD5_CHACN/23-77    AC A0A6J2URD5.1
#=GS A0A2Y9M6A9_DELLE/23-77    AC A0A2Y9M6A9.1
#=GS A0A3Q1F0Z6_9TELE/22-76    AC A0A3Q1F0Z6.1
#=GS A0A484GMR2_SOUCH/1-55     AC A0A484GMR2.1
#=GS A0A5A9NKA7_9TELE/34-88    AC A0A5A9NKA7.1
#=GS A0A6J3QTH7_TURTR/23-77    AC A0A6J3QTH7.1
#=GS A0A7N4NWZ6_SARHA/15-75    AC A0A7N4NWZ6.1
A0A3Q3GVJ4_9LABR/22-76               ........APMA.STEHGRELEDaPIVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSNKGPMPF......
A0A6I9MGS3_PERMB/23-77               ........VPLM.LPPDGKGLEE.GNVRYLVQPRASRTGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A553P983_9TELE/15-69               ........GPVA.STEHSKEIEEvGSMRTPLRQNPARAGRSQRPSGWKR-RRPRPRLSHKGPMPF......
A0A452DJT3_BOVIN/136-190             ........GPLL.QTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6P3F8X9_OCTDE/23-77               ........VPLM.QPPDGTALEE.GSVRYLVQPRTSRNGPAPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6J3GF65_SAPAP/23-77               ........GPLM.PLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A2Y9SZ03_PHYMC/23-77               ........GPLL.QTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
G1TTT0_RABIT/23-77                   ........GPLG.QPPQGNGLEE.GNVRYLLQPRAPRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A1XP38_XENLA/23-76                   ........APLA.EGSDRNDEEQ.-NIRTLVNPKMVRNSAPQRQANRRKLIRQRPRLSHKGPMPF......
A0A6P3GHG1_BISBI/22-76               ........GPLL.QTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6I8PRH6_ORNAN/20-74               .......r-PLP.EASDGRELEE.GHIRHLVQPKTMRNGVGPRQGGRRKFRRPRPRLSHKGPMPF......
A0A2Y9KMF0_ENHLU/23-77               ........GPLL.QPADGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A4W6FVM6_LATCA/28-82               ........GPMA.SMEHGRELEEaSTVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A6J1YXY3_ACIJB/23-77               ........GPLL.QPSDGNGLEE.SNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A2I2Z1U0_GORGO/23-77               ......gs--LM.PLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A3B5KED7_TAKRU/111-165             ........GPMA.STEHGKELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A3P9AED5_ESOLU/28-83               .....gpi--MA.STEHGAVLEEaGGVRRVAQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A2Y9GQL4_NEOSC/23-77               ........GPLL.QPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
W5PZT7_SHEEP/22-76                   ........GPLL.QTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6P8UPF5_GYMAC/23-77               ........GPMA.STEHGRGLQQaATVRKIAQQNPARGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A3Q3W1A2_MOLML/22-76               ........APMA.STEHGRELEEvAPVRKMVQQNPARGGQTHRQAGWKR-RRPRPRLSHKGPMPF......
A0A6J2QF47_COTGO/23-77               ........GPMA.STEHGRGLEEaARVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A4W5N3B3_9TELE/16-70               ......si--MD.STEHGTALEQaGSVRRLVQQNPGRGSQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A484CWX4_PERFV/23-60               ........GPMA.STEHGRELEEaATARKMVQQNPGRGGTH------------------------avleqg
A0A4D9DYI7_9SAUR/70-124              ........APLA.EAPDGRDLEK.GNIRNLVHPKGVRNGAGNRQNGWRKSRRPRPRLSHKGPMPF......
A0A452EV17_CAPHI/12-66               ........GPLL.QTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A669EFW3_ORENI/21-75               ........GPMA.STVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF......
A0A3N0Z006_ANAGA/1-54                ........-PMA.STEHSKELEEvGSMRTPLRQNPARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A3Q2ZEC5_KRYMA/22-74               ........APMA.STEHGRGLEEtATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF......
APEL_MOUSE/23-77                     ........VPLM.LPPDGTGLEE.GSMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF......
A0A452EUY8_CAPHI/18-72               ........GPLL.QTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6G1PUX7_9TELE/23-77               ........GPMA.STEHGRELEEtATVRKMVQQNPSRGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A3Q7XFM5_URSAR/23-77               ........GPLL.QPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A5G2R3Z5_PIG/23-77                 ........GPLL.QTSGGKGMEE.GNVRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6J2MI34_9CHIR/23-77               ........GPLL.QPPARKGLEE.SNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A671DPD8_RHIFE/23-77               ........GPLL.QPSAGKGLEE.GNIRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A1U7SBI1_ALLSI/9-63                ........GPLA.EAPDGKDPEE.GNIRNLVYPRGARNGAGHRQNGWRKYRRPRPRLSHKGPMPF......
A0A6I9JN85_CHRAS/26-78               .....ctp----.-PSDWQGLEE.GNVRHLVQPRGVRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A663EI76_AQUCH/21-75               ........GPLG.QAPDGKDAED.GLIRTLVRPRGARRGAGHRPSGWRRYRRPRPRLSHKGPMPF......
A0A3P8UVQ3_CYNSE/22-76               ........APMA.SVEHGREVEEaPTVRKMVQQSPARGGQPHRPAGWKR-RRPRPRLSHKVPMPF......
A0A667ZSA2_9TELE/25-79               ........GPMA.STEHGRELEEaATVRKLVQQSPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A5N5NXA0_PANHP/23-77               ........GPVT.STEHSKELEEvGSMRTPVRQNAARAGRNQRPSGWRR-RRPRPRLSHKGPMPF......
A0A1U7TII0_CARSF/23-77               ........GPLV.QSPDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSYKGPMPF......
A0A3Q2FIY1_CYPVA/22-74               ........APMA.STEHGRGLEGaNTVRKMAQQTPVRGGQTHRPS--KR-RRPRPRLSHKGPMPF......
A0A2K5Y1Q5_MANLE/23-77               ........GPLM.QLPYGNGLEE.GNVRHLVQPRGTRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A668W199_OREAU/21-75               ........GPMA.STVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF......
A0A671N367_9TELE/116-170             ........GPMA.STEHSKELEEvGSMRTPLRQNSARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A6P7J6L8_9TELE/23-77               ........GPMA.STEHGRELEEaATMRKMVQQNPTRGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A3Q7UL60_VULVU/70-124              .......w-PLL.QPPDGKGLEE.GNIRHLVQPRGSRNGLGPWQGGRKKFRRQRPRLSHKGPMPF......
A0A7F8QY06_LEPWE/87-141              ........GPLL.QPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A452RG05_URSAM/17-71               ........GPLL.QPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A670K5A7_PODMU/20-74               ........GPLS.ETSDGNEPVE.AHVLNLVHPKRVRSAVGHRQNGWRKYRRPRPRLSHKGPMPF......
A0A384CGN6_URSMA/24-78               .......r-PLL.QPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A7N6B6F2_ANATE/111-165             ........GPMA.STEHGRELEEaTSVRKMVQQNTARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
G1Q652_MYOLU/23-77                   ........GPLP.QPSAGKGLEE.GNIHHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A3P8S8N4_AMPPE/115-169             ........GPMA.STEHGRELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A2K5QLE1_CEBIM/23-77               ........GPLM.PLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A2I4AW38_9TELE/23-75               ........GPMA.STEHGRGLEEtATVRKMAQQNPMRGGQTHRPA--KR-RRPRPRLSHKGPMPF......
A9ULR5_XENTR/23-76                   ........APLA.EGSDRNDEEQ.-NIRTLVNPKMVRNPAPQRQANWRKIRRQRPRLSHKGPMPF......
A0A452GLA3_9SAUR/24-75               .....hpa----.--PDGRDLEK.GNIRNLVHPKGVRNGAGHRQNGWRKSRRPRPRLSHKGPMPF......
A0A2K6KLP8_RHIBE/23-77               ........GPLM.RLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A4W5RII3_9TELE/28-83               .....gpi--MA.STEHGTALEEaGAVRRLVQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A673WH90_SALTR/18-73               .....gpi--MA.STEHGKALEEaGAVRRLVQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A3Q7MMP1_CALUR/23-77               ........GPLL.QPSDGRGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A1S3A126_ERIEU/23-77               ........GPVL.QSGGRKGLQE.GSARHVAKPRGPRSGPGPWQGARKKLRRQRPRLSHKSPMPF......
A0A5F4CM34_CANLF/146-200             ........GPLL.QPSDGKALEE.GNIRHLVQPRGSRNGPGPWQGGRKKFRRQRPRLSHKGPMPF......
A0A3Q2HT60_HORSE/132-186             ........GPLL.QPPDGQGLEE.GDVRYLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A3Q1CW32_AMPOC/23-77               ........GPMA.STEHGRELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A498LPD1_LABRO/23-77               ........GPMA.STEHSKELEEvGSMRTPLRQNSARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A6I9NQB0_9TELE/23-77               ........GPMA.STEHGRGLQQaATVRKIVQQNSARGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A3B1J5L3_ASTMX/277-331             ........GPMA.STEHSKELEEvGSMRTPLRQTQARAGRSQRPSSWRR-RRPRPRLSHKGPMPF......
A0A2K6TVK2_SAIBB/23-77               ........GPLM.PLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
F7EWH6_MONDO/151-204                 ........GPLV.EPSDRKELEE.GNIRTLVQPKGARVG-GPWPGGRRKFRRQRPRLSHKGPMPF......
A0A674G8Y2_TAEGU/19-72               .......g--LV.LAPDGKDAQN.GLTRRLVRPRGARRGTGQRPGGWRRSRRPRPRLSHKGPMPF......
A0A6P7YN13_9AMPH/23-77               ........GPLA.ESSDGNVPEE.DGIRNLVHPKGVRNGAGHRQGHWRKYRRQRPRLSHKGPMPF......
A0A1S3SSH3_SALSA/23-78               .....gpi--MA.STEHGKALEEaGAVRRLVQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A671WAG3_SPAAU/30-84               ........GPMA.STEHGRELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A2K6B2K3_MACNE/23-77               ........GPLM.QLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A3P9BJI6_9CICH/22-76               ........APMA.STVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF......
A0A669PRG7_PHACC/24-78               ........GPLG.AGLDGMDPED.GLIRTLVRPRGARRGNVRRPGGWRRIRRPRPRLSHKGPMPF......
W5NDT8_LEPOC/23-77                   ........GPLA.STEQSKDMEEgGSVRKLVQHSAARGGQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A4V6ANC4_COLLU/67-121              ........GPMA.STEHGKELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
G3U153_LOXAF/23-77                   ........GPLM.QPSERKGLEE.GNVRHLVQPRGVRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
APEL_HUMAN/23-77                     ......gs--LM.PLPDGNGLED.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A7N8Y2E8_9TELE/7-61                ........GPMA.STEHGKELEEaATMRKMVQQNPARGGQTHRPAGFKR-RRPRPRLSHKGPMPF......
A0A6P5ITS1_PHACI/23-76               ........GPLV.EALDRKELEE.GNIRTLVQPKVARTG-GPWQGGRRKFRRQRPRLSHKGPMPF......
A0A5N3XG03_MUNRE/18-72               ........GPLL.QTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A673CYF0_9TELE/107-161             ........GPMA.STEHGRELEEaATVRKLVQQNPARTGQTHRPSGWKR-RRPRPRLSHKGPMPF......
A0A672K9E7_SINGR/12-66               .......s-PMA.STEHSKELEEvGSMRTPLRQNPARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A673LNB8_9TELE/132-186             ........GPMA.STEHSKELEEvGSMRTPLRQNSARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A6P6IPL8_PUMCO/23-77               ........GPLL.QPSDGNGLEE.SNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A671PZY5_9TELE/23-77               ........GPMA.STEHSKELEEvGSMRTPLRQNPARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A485NZH6_LYNPA/8-62                ........GPLL.QPSDGNGLEE.SNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A337S4B6_FELCA/23-77               ........GPLL.QPSDGNGLEE.SNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
APEL_RAT/23-77                       ........VPLM.LPPDGKGLEE.GNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF......
A0A4W4FZJ5_ELEEL/173-227             ........APVA.STEHSKELEEvNSMRAPARQSPARAGRNQRPAGWRR-RRPRPRLSHKGPMPF......
A0A6P3VLL1_CLUHA/23-77               ........GPMA.STEHSKGLEEaDTARNPVQQNPGRGGRSQRPNGWRR-RRPRPRLSHKGPMPF......
A0A556V0T9_BAGYA/23-77               ........GPVT.STEHSKELEEvGSMKTPVRQNPARAGRNQRPSGWRR-RRPRPRLSHKGPMPF......
A0A7N5K9G0_AILME/156-210             ........GPLL.QPSDGTWLEE.GSVHHLMQPKGSRNRPGPWQGGRRKFRRQRPRLSHKSPMPF......
A0A6J3A312_VICPA/9-63                ........GPLL.QTSDGKGMEE.ANIRHLVQPRGPRSRAGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A2K5IYX0_COLAP/23-77               ........GPLM.RLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6P6LAE1_CARAU/48-102              ........GPVA.STEHSKELEEvGSMRTPLRQNPARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A2U9CAC4_SCOMX/23-57               ........GPMA.SVEHGRELEEaSAVRKMVQQSPARGGCCDR----------------------g.....
A0A2K6EG20_PROCO/23-77               ........GPLM.QPPEGKGLEE.GKVRHLVQPRASRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
M4AGL4_XIPMA/22-74                   ........APMA.STEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF......
A0A673ZU53_SALTR/15-70               ........GPIMdSKEHGTALEQaGGVRRLVQQNPGRGSQSHRPAGWKR-RRPRPRLSHKGPMPF......
A0A672T4Q1_SINGR/125-179             ........GPMA.STEHSKELEEvGSMRTPLRQNSARAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A2K6RR72_RHIRO/23-77               ........GPLM.QLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A4W3HLR3_CALMI/20-72               .......r-PVA.LLSEGSALED.GGIRTYVRKA--GRGSSHRQPPMKKYRRLRPRLSHKGPMPF......
A0A5E4CPB6_MARMO/23-75               ........VPLM.QPPDGKELEE.GNVRYLVQPRASRNG--PWQGGRRKFRRQRPRLSHKGPMPF......
A0A6P5B4Y6_BOSIN/23-77               ........GPLL.QTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A3Q4N6C1_NEOBR/22-76               ........APMA.STVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF......
W5PZT6_SHEEP/28-82                   ........GPLL.QTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A493T7U4_ANAPP/25-76               ....gplp----.---DGTGPQR.GRIRVLVRPRGARRGAGQRAGGWRRLRRPRPRLSHKGPMPF......
A0A1L7HA09_CHICK/24-78               ........GPLG.AGLDGMDPED.GLIRTLVRPRGARRGNVRRPGGWRRLRRPRPRLSHKGPMPF......
APEL_BOVIN/23-77                     ........GPLL.QTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A6P3RLY6_PTEVA/23-77               ........GPLM.QPSAGKGLKE.GTIHHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A286XKG6_CAVPO/23-75               ........VPLL.QPPDGKGLEE.--VSYLVQPRASRNGPAPWQGGRRKFRRQRPRLSHKGPMPF......
A0A1S3FAK0_DIPOR/23-77               ........VPLM.LPSDGNGMEE.GNLHYLVQPRASRNGPGTWQGGRRKFRRQRPRLSHKGPMPF......
A0A1U7R0D2_MESAU/23-77               ........VPLM.LPSDGKGLEE.GNMRYLVQPRASRTGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A670YC81_PSETE/17-71               ........GPVS.EASDGKELLE.GQDVNMAHPKVVRSVGGHRHNAWRRYRRPRPRLSHKGPMPF......
A0A673KQE5_9TELE/13-59               ........GPMA.STEHSKELEEvGSMRTPLRQNPARAGRSQRPSGWRR-RRPR-----------lcf...
A0A672JE25_SALFA/121-175             ........GPMA.STEHGRELEEaATVRKVVQQNPPRGGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A665UGS1_ECHNA/31-83               .......c-PMA.SMKHGRELEEaSTVRKMVQQSA--GGQTHRSAGWKK-RRQRPHLSQKGPMPF......
A0A3P9P6G2_POERE/22-74               ........APMA.STEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF......
A0A6P7NT53_BETSP/23-77               ........GPMA.STEHGRELEEaAAVRKMVQQNGARAGQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A0D9R7Q2_CHLSB/23-77               ........GPLM.QLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A4X2JTI2_VOMUR/23-76               ........GPLV.EASDRKELEE.GNIRTLVQPKVARTG-GPWQGGRRKLRRQRPRLSHKGPMPF......
A0A6J3DSQ2_AYTFU/24-75               ....gplp----.---DGTGPER.GRIRALVRPRGARRGAGQRAGGWRRLRRPRPRLSHKGPMPF......
A0A3B3IPB5_ORYLA/22-76               ........APMA.STEHGKDLGEtATVKKMVQQNPARGGQPQRPAGWKR-RRPRPRLSHKGPMPF......
A0A3Q3C5Y7_HAPBU/22-76               ........APMA.STVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF......
A0A287D3D8_ICTTR/23-75               ........VPLM.QPPDGKELEE.GNVRYLVQPRASRNG--PWQGGRRKFRRQRPRLSHKGPMPF......
A0A2U3VXS2_ODORO/23-77               ........GPLL.RPSDGRGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF......
APEL_DANRE/23-77                     ........GPMA.STEHSKEIEEvGSMRTPLRQNPARAGRSQRPAGWRR-RRPRPRLSHKGPMPF......
A0A674IVS8_TERCA/7-61                ........APLS.EAPDGRDLEK.GNIRNLAHPKGMRNGAGHRQNGWRKSRRPRPRLSHKGPMPF......
A0A6J2URD5_CHACN/23-77               ........GPMA.STEHSKEVEEvGSMRTPVRQSPGRAGRSQRPSGWRR-RRPRPRLSHKGPMPF......
A0A2Y9M6A9_DELLE/23-77               ........GPLL.QTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A3Q1F0Z6_9TELE/22-76               ........APMA.STEHGRELEEgATVRKMVQQNPARGSQTHRPAGWKR-RRPRPRLSHKGPMPF......
A0A484GMR2_SOUCH/1-55                ........GPLL.QTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A5A9NKA7_9TELE/34-88               ........GPMA.STEHSKELEEmSSMRTPLRQNSARAGRNQRPSGWRR-RRPRPRLSHKGPMPF......
A0A6J3QTH7_TURTR/23-77               ........GPLL.QTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF......
A0A7N4NWZ6_SARHA/15-75               sqraqfrr-PLL.EALDRKELEE.GNIRTLVQPKMARTG-GPWQGGRRKFRRQRPRLSHKGPMPF......
#=GC seq_cons                        ........GPhh.pspcG+tLEE.GslRpLVQ.psuRsG.u.h.uGhR+.RR.RPRLSHKGPMPF......
//
DBGET integrated database retrieval system