GenomeNet

Database: Pfam
Entry: BILBO1_N
LinkDB: BILBO1_N
Original site: BILBO1_N 
#=GF ID   BILBO1_N
#=GF AC   PF18281.4
#=GF DE   BILBO1 N-terminal domain
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF03912
#=GF GA   28.30 28.30;
#=GF TC   28.30 28.80;
#=GF NC   27.70 27.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0072
#=GF RN   [1]
#=GF RM   24362019
#=GF RT   Structure of the TbBILBO1 protein N-terminal domain from
#=GF RT   Trypanosoma brucei reveals an essential requirement for a
#=GF RT   conserved surface patch.
#=GF RA   Vidilaseris K, Morriswood B, Kontaxis G, Dong G;
#=GF RL   J Biol Chem. 2014;289:3724-3735.
#=GF DR   INTERPRO; IPR040747;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-terminal domain of BIBLO1 present in Trypanosoma
#=GF CC   brucei. BILBO1 is a flagella pocket collar component. Depletion
#=GF CC   of BIBLO1 prevents flagella pocket and flagella pocket collar
#=GF CC   biogenesis and leads to cell death. This domain has a
#=GF CC   ubiquitin-like fold and has a conserved patch of four aromatic
#=GF CC   residues (Phe-12, Trp-71, Tyr-87, and Phe-89) and three basic
#=GF CC   residues (Lys-15, Lys-60, and Lys-62) [1].
#=GF SQ   32
#=GS A0A0S4J2G2_BODSA/13-106  AC A0A0S4J2G2.1
#=GS A0A061J940_TRYRA/13-109  AC A0A061J940.1
#=GS A0A0N0VE56_9TRYP/13-102  AC A0A0N0VE56.1
#=GS A4I5M3_LEIIN/14-102      AC A4I5M3.1
#=GS A0A504XB94_LEIDO/14-102  AC A0A504XB94.1
#=GS A0A0N0VFA6_9TRYP/13-109  AC A0A0N0VFA6.1
#=GS A0A422N0I0_TRYRA/13-106  AC A0A422N0I0.1
#=GS Q584W7_TRYB2/16-104      AC Q584W7.1
#=GS A0A061J957_TRYRA/68-161  AC A0A061J957.1
#=GS Q4Q798_LEIMA/14-102      AC Q4Q798.1
#=GS A0A0N0VGD2_9TRYP/14-103  AC A0A0N0VGD2.1
#=GS A0A3Q8IH20_LEIDO/13-110  AC A0A3Q8IH20.1
#=GS F9WJP4_TRYCI/16-104      AC F9WJP4.1
#=GS A0A7G2C503_9TRYP/13-97   AC A0A7G2C503.1
#=GS A0A1X0P2G1_9TRYP/14-102  AC A0A1X0P2G1.1
#=GS A0A422NI28_9TRYP/14-102  AC A0A422NI28.1
#=GS A0A0S4JNL3_BODSA/13-100  AC A0A0S4JNL3.1
#=GS K2NJB7_TRYCR/14-102      AC K2NJB7.1
#=GS V5BQB2_TRYCR/13-106      AC V5BQB2.1
#=GS A4HNY8_LEIBR/13-110      AC A4HNY8.1
#=GS A0A1X0P9F2_9TRYP/13-107  AC A0A1X0P9F2.1
#=GS V5BPG5_TRYCR/14-102      AC V5BPG5.1
#=GS Q38B39_TRYB2/13-107      AC Q38B39.1
#=GS Q4Q1U5_LEIMA/13-110      AC Q4Q1U5.1
#=GS A4ICK5_LEIIN/13-110      AC A4ICK5.1
#=GS A0A422NE50_TRYRA/13-110  AC A0A422NE50.1
#=GS Q382W6_TRYB2/14-107      AC Q382W6.1
#=GS Q382W6_TRYB2/14-107      DR PDB; 2MEK A; 14-107;
#=GS Q4CQR5_TRYCC/14-102      AC Q4CQR5.1
#=GS A4HID0_LEIBR/14-102      AC A4HID0.1
#=GS A0A3S5IRG0_9TRYP/13-106  AC A0A3S5IRG0.1
#=GS Q4D883_TRYCC/14-102      AC Q4D883.1
#=GS A0A3R7MW67_TRYRA/14-102  AC A0A3R7MW67.1
A0A0S4J2G2_BODSA/13-106             .EKLNLEITFPTM-P-TIGELQRKIIEVY..N.NE.AN.....V.....K.R.pQ.G...Y.P.AvE..FSIARLQIYDDVMLKWTDLVACTQLHEYDQLYAFQPQ-...-...-----------spwhidvqkdlpppr...
A0A061J940_TRYRA/13-109             a-KVNFELTFPRR-P-TLPEVLRATEGAF..S.NE.IA.....L.....R.RpeN.V...P.P.H.T..FNVSKIKLYDEDRNKWVDLVSEGQLTDYCQLYAFQPDN...-...-----------qwhkesqkeipaavkpp.
A0A0N0VE56_9TRYP/13-102             n-KLNFELSFPSR-P-TVQEITRASEAAF..StEI.AN.....T.....R.A..D.N...VpP.H.T..FHIAKIKIYDEDKSKWVDLLGEGQLVDYCQLYAFQPE-...-...-----------npwhketqkpi.......
A4I5M3_LEIIN/14-102                 .EKVNLALRYNPR-TTTLDRFLSVASRCF..D.DV.AH.....L.....T.R..R.G...C.L.Q.P..FSA--AYIYRDVQCQWDVLEDCTQLSPFCQVYVFRQLF...N...EVVAAISDPLD..................
A0A504XB94_LEIDO/14-102             .EKVNLALRYNPR-TTTLDRFLSVASRCF..D.DV.AH.....L.....T.R..R.G...C.L.Q.P..FSA--AYIYRDVQCQWDVLEDCTQLSPFCQVYVFRQLF...N...EVVAAISDPLD..................
A0A0N0VFA6_9TRYP/13-109             .EKVNLEVTLESP-PVSLQDLAASLTPVFarE.EV.AM.....L.....A.R..Q.GyaaS.A.P.T..FQIANVFLYDDVLLHWTKLKSITQLHEYDQLYVFQPQT...-...-----------qrhrdtqqdlppp.....
A0A422N0I0_TRYRA/13-106             .EKCNLELGFSSM-P-TIAELQRKVLEVF..Q.ME.AS.....M.....R.R..PpG...YpV.A.N..FTIVRVQIYDDALLKWVDLVSQTQMHEYDQLYVFQPQTswhT...DVQKDLP----ppr...............
Q584W7_TRYB2/16-104                 .EKVNLRFLFDAAGP-SVSRLLNYSTTAF..N.NY.FR.....L.....K.G..-.-...I.S.R.A..FAVNSAVVFNDVHCTWDRLERTTQLLHNSQVYLFQPDT...L...DIPAAIPEPYE..................
A0A061J957_TRYRA/68-161             .EKCNLELGFSSM-P-TIAELQRKVLEVF..E.VE.AS.....M.....R.R..PpG...Y.PvV.D..FTIARVQIYDDALLKWVDLVSQTQMHEYDQLYVFQPQTswhT...DVQKDLP----ppr...............
Q4Q798_LEIMA/14-102                 .EKVNLALRYNPR-TTTVDCFLSAASRCF..D.DV.AH.....L.....M.R..Q.G...S.L.Q.P..FSA--AYIYRDVQCQWDVLEDRTQLSPFCQVYVFRQLF...N...EVVAAIPDPLD..................
A0A0N0VGD2_9TRYP/14-103             .EKINVAVRYNPRTE-TLVHLFANAETAF..A.LFtMQ.....Y.....A.H..E.E...P.L.Q.P..FAF--AYAYSDVQCQWNLLEGRDQLSPCCQVYVFRCGG...Q...ESVDAIPEPI-n.................
A0A3Q8IH20_LEIDO/13-110             n-KVNLEIALETF-PATLRCLESDIARIF..S.RE.VEesgtvE.....H.R..T.N...V.A.E.P..FQVMSVVIYDDVLLRWTKLKSLAQLHEYDQLYVFQPQTqwhV...DLQKELPPP--r.................
F9WJP4_TRYCI/16-104                 v-KVNLRFLFDAS-ELTVSRMLRRATVAF..S.NY.FR.....-.....-.R..K.G...I.E.H.E..FAANSVVVFNDAHCTWDRLERTTQLFTNSQVYLFQPDT...V...DVPAAIPEPID..................
A0A7G2C503_9TRYP/13-97              .EKVNLEITLDDA-PHSVS-FLEYSV---..A.RV.FT.....L.....E.A..-.G...R.L.-.-..VQAACLYIYDDANLLWTKLENVGQLCEYDQLYLFQPQT...-...-----------tthadaqqdlppp.....
A0A1X0P2G1_9TRYP/14-102             .EKVNLRFLFDAYGP-SVTQLLNRAIVAF..N.NL.FH.....H.....C.-..-.G...I.P.R.A..FAASAAVVFNETQCTWDRLVRSTQLLHNSQVYLFQPDI...L...DLPAVIPEPYE..................
A0A422NI28_9TRYP/14-102             .EKVNLRFLFDSYGP-SLAQLLNRSLVAF..N.NV.FR.....L.....R.S..-.-...V.P.R.T..FAVSAAVVFNDVHNTWDRLERSTQLLHNSQVYLFQPDI...L...DMPAEIPEPFE..................
A0A0S4JNL3_BODSA/13-100             .DKVNLQFFFEF-GP-SVAQVLSRASEAF..R.AL.FR.....Q.....R.-..-.G...I.D.R.I..FVTSASVIFNDALECWDRLDRSTQLVHNCQLYIFQPDV...L...DIPAEIGDPI-p.................
K2NJB7_TRYCR/14-102                 .EKANLRFLFDSYGP-SVAQLLNRSIVAF..N.NL.FR.....L.....R.S..-.-...V.P.R.T..FAVSAAVVFNDVHSTWDRLERSTQLLHNSQVYLFQPDI...L...DLPAEIPEPFE..................
V5BQB2_TRYCR/13-106                 .DKCNLELGFLSM-P-TMTQLQEKVLQVF..E.AE.AN.....I.....R.R..PsG...YpV.M.D..FTIARIQIYDDALLKWVDLVSQTQMHEYDQLYVFQPQTpwhT...DVQKDLPP---pc................
A4HNY8_LEIBR/13-110                 .DKVNLEITLDAF-PATVQRLEADIVRIF..NrEV.EQ.....Ls..alQnS..T.S...V.T.E.P..FQVMSIFIYDDVLLRWTKLKSVAQLHEYDQLYVFQPQT...QwhvDVQKDLP----ppr...............
A0A1X0P9F2_9TRYP/13-107             .EKCNLELNFASM-P-TLAELQRKILLVF..S.AE.SN.....L.....RhS..Q.G...G.L.P.TvdFTIARIQIYDDVLLKWVDLISPTQLHEYDQLYVFQPQTswhT...DVQKDLPP---pc................
V5BPG5_TRYCR/14-102                 .EKANLRFLFDSYGP-SVAQLLNRSIVAF..N.NL.FR.....L.....R.S..-.-...V.P.R.T..FAVSAAVVFNDVHSTWDRLERSTQLLHNSQVYLFQPDI...L...DLPAEIPEPFE..................
Q38B39_TRYB2/13-107                 .EKYNLEVRFPSK-P-TIEDLQKRIVTVF..S.TE.MD.....S.....R.R.pE.G...Y.P.EaD..FSIALVHIYDDKSQQWEKLLSDAQLHEYDQLYVFQPQTrwhM...DVQKNLPPP--tt................
Q4Q1U5_LEIMA/13-110                 n-KVNLEIALDTF-PATLRGLESDIARIF..N.RE.VEksgavE.....H.N..A.N...V.A.E.P..FQVMSVFVYDDVLLRWTKLESLTQLHEYDQLYVFQPQTqwhV...DVQKELPPP--r.................
A4ICK5_LEIIN/13-110                 n-KVNLEIALETF-PATLRCLESDIARIF..S.RE.VE.....EsgtgeH.R..T.N...V.A.E.P..FQVMSVVIYDDVLLRWTKLKSLAQLHEYDQLYVFQPQTqwhV...DLQKELPPP--r.................
A0A422NE50_TRYRA/13-110             s-KVNFELTFPRR-P-TLPEVLHATEAAF..S.NE.IA.....L.....R.R..P.Eh.vP.P.H.T..FNVAKIKLYDEDRNKWVDLVSEGQLTDYCQLYAFQPDN...-...-----------qwhkesqkeipaavkppm
Q382W6_TRYB2/14-107                 n-KVNFELSFPSR-P-SISELTRSAETAF..S.NE.IS.....L.....R.R..P.D..nV.PsH.K..FHSSKIKMYDEELNKWVDLIREDQLTDYCQLYVFQP--...-...-----------pnewhkesqkeippam..
#=GR Q382W6_TRYB2/14-107      SS    --EEEEEEEESS-----SHHHHHHHHHHH..H.HH.HH.....H.....H.S..-.S..SS.---.-..----EEEEEETTTTEEEE--SS-TTTTS-EEEEE----...-...------------SS--S------SS--..
Q4CQR5_TRYCC/14-102                 .EKANLRFLFDSYGP-SVAQLLNRSIVAF..N.NL.FR.....L.....R.S..-.-...V.P.R.T..FAISAAVVFNDVHSTWDRLERSTQLLHNSQVYLFQPDI...L...DLPAEIPEPFE..................
A4HID0_LEIBR/14-102                 .EKVNLALRYNPW-TDTLDHLLTAASHCF..A.GV.AH.....L.....M.C..Q.G...P.L.P.P..FSA--AYIYQDVQFQWDALQDRTQLSPCCQVYVFREAF...D...EIVAAIPDPLD..................
A0A3S5IRG0_9TRYP/13-106             .EKCNLELGFPSA-P-TIAELQRKALEVF..E.AE.AN.....M.....R.R..PsG...YpV.V.D..FAIVRVQIYDDALLKWVDLVSQTQMHEYDQLYVFQPQS...-...-----------awhtdvqkdlpppr....
Q4D883_TRYCC/14-102                 .EKANLRFLFDSYGP-SVAQLLNRSIVAF..N.NL.FR.....L.....R.S..-.-...V.P.R.T..FAVSAAVVFNDVHSTWDRLERSTQLLHNSQVYLFQPDI...L...DLPAEIPEPFE..................
A0A3R7MW67_TRYRA/14-102             .EKVNLRFLFDSYGP-SLVQLLNRSIVAF..N.NV.FR.....L.....R.S..-.-...V.P.R.I..FAVSAAVVFNDVHSTWDRLERSTQLLHNSQVYLFQPDI...L...DLPAEIPEPFE..................
#=GC SS_cons                        --EEEEEEEESS-----SHHHHHHHHHHH..H.HH.HH.....H.....H.S..-.S..SS.---.-..----EEEEEETTTTEEEE--SS-TTTTS-EEEEE----...-...------------SS--S------SS--..
#=GC seq_cons                       .EKlNLcltFssh.P.TlspLhpcshtsF..s.s..hp.....l.....+.p....s...s.s.p.s..FslstshlYcDshhpWscLpspTQLpcasQlYlFQPph.......-l.ttlP......................
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