#=GF ID BTB
#=GF AC PF00651.35
#=GF DE BTB/POZ domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Bardwell VJ;
#=GF SE Prosite
#=GF GA 20.50 20.50;
#=GF TC 20.50 20.50;
#=GF NC 20.40 20.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF WK BTB/POZ_domain
#=GF CL CL0033
#=GF RN [1]
#=GF RM 7938017
#=GF RT The BTB domain, found primarily in zinc finger proteins, defines
#=GF RT an evolutionarily conserved family that includes several
#=GF RT developmentally regulated genes in Drosophila.
#=GF RA Zollman S, Godt D, Prive GG, Couderc JL, Laski FA;
#=GF RL Proc Natl Acad Sci U S A 1994;91:10717-10721.
#=GF RN [2]
#=GF RM 7958847
#=GF RT The POZ domain: a conserved protein-protein interaction motif.
#=GF RA Bardwell VJ, Treisman R;
#=GF RL Genes Dev 1994;8:1664-1677.
#=GF RN [3]
#=GF RM 9770450
#=GF RT Crystal structure of the BTB domain from PLZF.
#=GF RA Ahmad KF, Engel CK, Prive GG;
#=GF RL Proc Natl Acad Sci U S A 1998;95:12123-12128.
#=GF RN [4]
#=GF RM 9019154
#=GF RT The LAZ3/BCL6 oncogene encodes a sequence-specific
#=GF RT transcriptional inhibitor: a novel function for the BTB/POZ
#=GF RT domain as an autonomous repressing domain.
#=GF RA Deweindt C, Albagli O, Bernardin F, Dhordain P, Quief S,
#=GF RA Lantoine D, Kerckaert JP, Leprince D;
#=GF RL Cell Growth Differ 1995;6:1495-1503.
#=GF RN [5]
#=GF RM 9824158
#=GF RT The BCL-6 POZ domain and other POZ domains interact with the
#=GF RT co-repressors N-CoR and SMRT.
#=GF RA Huynh KD, Bardwell VJ;
#=GF RL Oncogene 1998;17:2473-2484.
#=GF RN [6]
#=GF RM 9765306
#=GF RT Components of the SMRT corepressor complex exhibit distinctive
#=GF RT interactions with the POZ domain oncoproteins PLZF,
#=GF RT PLZF-RARalpha, and BCL-6.
#=GF RA Wong CW, Privalsky ML;
#=GF RL J Biol Chem 1998;273:27695-27702.
#=GF RN [7]
#=GF RM 16207353
#=GF RT Sequence and structural analysis of BTB domain proteins.
#=GF RA Stogios PJ, Downs GS, Jauhal JJ, Nandra SK, Prive GG;
#=GF RL Genome Biol. 2005;6:R82.
#=GF DR INTERPRO; IPR000210;
#=GF DR PROSITE_PROFILE; PS50097;
#=GF DR SCOP; 1buo; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and
#=GF CC Zinc finger) [2] domain is present near the N-terminus of a
#=GF CC fraction of zinc finger (Pfam:PF00096) proteins and in proteins
#=GF CC that contain the Pfam:PF01344 motif such as Kelch and a family
#=GF CC of pox virus proteins. The BTB/POZ domain mediates homomeric
#=GF CC dimerisation and in some instances heteromeric dimerisation [2].
#=GF CC The structure of the dimerised PLZF BTB/POZ domain has been
#=GF CC solved and consists of a tightly intertwined homodimer. The
#=GF CC central scaffolding of the protein is made up of a cluster of
#=GF CC alpha-helices flanked by short beta-sheets at both the top and
#=GF CC bottom of the molecule [3]. POZ domains from several zinc finger
#=GF CC proteins have been shown to mediate transcriptional repression
#=GF CC and to interact with components of histone deacetylase
#=GF CC co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ
#=GF CC or BTB domain is also known as BR-C/Ttk or ZiN.
#=GF SQ 160275
#=GS A0A3Q7RGH7_VULVU/28-135 AC A0A3Q7RGH7.1
#=GS A0A1X6NDS3_9APHY/14-122 AC A0A1X6NDS3.1
#=GS A0A8B9DYQ2_ANSCY/23-130 AC A0A8B9DYQ2.1
#=GS A0A5N6ZID6_9EURO/11-107 AC A0A5N6ZID6.1
#=GS A0A8C6MUW1_MUSSI/24-129 AC A0A8C6MUW1.1
#=GS A0A372RZ44_9GLOM/11-121 AC A0A372RZ44.1
#=GS A0A091EUS7_CORBR/21-128 AC A0A091EUS7.1
#=GS A0A2G9QFU9_LITCT/5-111 AC A0A2G9QFU9.1
#=GS A0A673AY59_9TELE/187-241 AC A0A673AY59.1
#=GS T1JPJ0_STRMM/545-640 AC T1JPJ0.1
#=GS A0A1E1LBC4_9HELO/27-138 AC A0A1E1LBC4.1
#=GS W5LBZ6_ASTMX/757-869 AC W5LBZ6.2
#=GS A0A8I5NPV1_PAPAN/15-121 AC A0A8I5NPV1.1
#=GS A0A8B9DAZ0_ANSCY/36-142 AC A0A8B9DAZ0.1
#=GS A0A015J768_RHIIW/5-121 AC A0A015J768.1
#=GS A0A5N7AHQ2_9EURO/8-91 AC A0A5N7AHQ2.1
#=GS A0A2P4Q740_RHIID/13-129 AC A0A2P4Q740.1
#=GS A0A367IYD8_RHIST/396-505 AC A0A367IYD8.1
#=GS A0A852IZS9_9PICI/14-121 AC A0A852IZS9.1
#=GS A0A8C8J515_ONCTS/14-122 AC A0A8C8J515.1
#=GS A0A2K6KJA1_RHIBE/451-517 AC A0A2K6KJA1.1
#=GS I3J2J2_ORENI/24-131 AC I3J2J2.2
#=GS A0A1V6NQZ1_PENPO/18-129 AC A0A1V6NQZ1.1
#=GS A0A7L1B6K7_GYMTI/15-122 AC A0A7L1B6K7.1
#=GS A0A7K5HCL9_CROSL/113-222 AC A0A7K5HCL9.1
#=GS A0A452DVU3_CAPHI/23-127 AC A0A452DVU3.1
#=GS A0A6P6CCG8_PTEVA/14-122 AC A0A6P6CCG8.1
#=GS A0A2A4K6G4_HELVI/22-121 AC A0A2A4K6G4.1
#=GS A0A665WKJ7_ECHNA/88-179 AC A0A665WKJ7.1
#=GS A0A3Q2H1L1_HORSE/30-160 AC A0A3Q2H1L1.1
#=GS A0A0E0GK76_ORYNI/32-119 AC A0A0E0GK76.1
#=GS A0A3Q7TR89_VULVU/17-116 AC A0A3Q7TR89.1
#=GS A0A851V0X3_9PASS/555-654 AC A0A851V0X3.1
#=GS A0A067S741_GALM3/274-411 AC A0A067S741.1
#=GS A0A7K9MIS5_OCETE/21-133 AC A0A7K9MIS5.1
#=GS A0A7K9C202_9PICI/22-129 AC A0A7K9C202.1
#=GS A0A6L2P977_COPFO/580-688 AC A0A6L2P977.1
#=GS A0A6P3IJF4_BISBI/115-222 AC A0A6P3IJF4.1
#=GS A0A7K7QGH0_POEAT/36-144 AC A0A7K7QGH0.1
#=GS A0A673HVU3_9TELE/22-130 AC A0A673HVU3.1
#=GS A0A6G0HEF5_LARCR/31-138 AC A0A6G0HEF5.1
#=GS A0A6P4Z243_BRABE/12-118 AC A0A6P4Z243.1
#=GS A0A0V1AUD3_TRISP/497-604 AC A0A0V1AUD3.1
#=GS A0A3P8XVZ5_ESOLU/27-105 AC A0A3P8XVZ5.2
#=GS A0A7L0RW67_GLABR/21-129 AC A0A7L0RW67.1
#=GS A0A8H4P6I5_9HYPO/897-1022 AC A0A8H4P6I5.1
#=GS A0A8D0A9H3_SANLU/22-129 AC A0A8D0A9H3.1
#=GS A0A2K5QUP8_CEBIM/268-316 AC A0A2K5QUP8.1
#=GS M1A7N8_SOLTU/325-441 AC M1A7N8.1
#=GS A0A7K9HNJ0_9AVES/381-455 AC A0A7K9HNJ0.1
#=GS A0A803VD95_FICAL/26-131 AC A0A803VD95.1
#=GS A0A3Q3LXH9_9TELE/209-317 AC A0A3Q3LXH9.1
#=GS A0A5A9P229_9TELE/28-137 AC A0A5A9P229.1
#=GS A0A8C0A5P8_BOSMU/98-208 AC A0A8C0A5P8.1
#=GS A0A397U6J0_9GLOM/160-223 AC A0A397U6J0.1
#=GS A0A183J0E3_9BILA/136-222 AC A0A183J0E3.1
#=GS A0A5D3AFV2_GOSMU/16-119 AC A0A5D3AFV2.1
#=GS A0A4S8IQN5_MUSBA/49-159 AC A0A4S8IQN5.1
#=GS A0A397JQW2_9GLOM/13-126 AC A0A397JQW2.1
#=GS A0A2U3ZHN0_ODORO/279-327 AC A0A2U3ZHN0.1
#=GS F9XN86_ZYMTI/637-722 AC F9XN86.1
#=GS A0A835AVZ1_9POAL/182-294 AC A0A835AVZ1.1
#=GS A0A7L2FBE3_QUIME/36-144 AC A0A7L2FBE3.1
#=GS A0A8D2ML40_ZONAL/20-131 AC A0A8D2ML40.1
#=GS A0A6J1YU39_ACIJB/20-122 AC A0A6J1YU39.1
#=GS A0A093JLR5_STRCA/22-117 AC A0A093JLR5.1
#=GS A0A1S3B5E6_CUCME/183-304 AC A0A1S3B5E6.1
#=GS A0A7L2IAK2_9PICI/12-121 AC A0A7L2IAK2.1
#=GS A0A3Q3BBL0_KRYMA/40-146 AC A0A3Q3BBL0.1
#=GS A0A8C6HEV8_MUSSI/75-183 AC A0A8C6HEV8.1
#=GS W5M967_LEPOC/50-173 AC W5M967.1
#=GS A0A672U9F2_STRHB/8-79 AC A0A672U9F2.1
#=GS A0A8J2S5F3_9CRUS/196-302 AC A0A8J2S5F3.1
#=GS A0A8H3G804_9LECA/7-102 AC A0A8H3G804.1
#=GS A0A3Q3GGX4_9LABR/73-183 AC A0A3Q3GGX4.1
#=GS A0A2I0KIV1_PUNGR/21-108 AC A0A2I0KIV1.1
#=GS A0A6G1PUA8_9TELE/26-135 AC A0A6G1PUA8.1
#=GS A0A397G2W6_9GLOM/13-129 AC A0A397G2W6.1
#=GS A0A4E0QV71_FASHE/40-148 AC A0A4E0QV71.1
#=GS A0A8R2HAN8_ACYPI/92-145 AC A0A8R2HAN8.1
#=GS T1HVI3_RHOPR/1316-1424 AC T1HVI3.1
#=GS A0A6G0UJ38_9BILA/249-356 AC A0A6G0UJ38.1
#=GS A0A7K4V1C7_9EMBE/757-858 AC A0A7K4V1C7.1
#=GS E3MTA7_CAERE/4-126 AC E3MTA7.1
#=GS A0A671XSJ0_SPAAU/18-125 AC A0A671XSJ0.1
#=GS A0A8B9IMN0_ANSCY/256-397 AC A0A8B9IMN0.1
#=GS A0A8E0QU32_9EURO/336-428 AC A0A8E0QU32.1
#=GS A0A6J1JD90_CUCMA/57-154 AC A0A6J1JD90.1
#=GS A0A2R8MB73_CALJA/34-141 AC A0A2R8MB73.1
#=GS A0A8I6XH93_HORVV/96-214 AC A0A8I6XH93.1
#=GS A0A6P8B8D7_MAGGR/36-141 AC A0A6P8B8D7.1
#=GS A0A1U7X139_NICSY/180-299 AC A0A1U7X139.1
#=GS A0A2B7Y229_9EURO/76-185 AC A0A2B7Y229.1
#=GS A0A1Z5TVJ3_HORWE/13-129 AC A0A1Z5TVJ3.1
#=GS A0A8B8FCV3_9HEMI/31-88 AC A0A8B8FCV3.1
#=GS NS1BA_DANRE/22-129 AC Q5RG82.1
#=GS A0A669EM77_ORENI/65-172 AC A0A669EM77.1
#=GS A0A8B7MZ00_HYAAZ/20-115 AC A0A8B7MZ00.1
#=GS A0A8B7IU41_9AVES/473-581 AC A0A8B7IU41.1
#=GS A0A8D0BDU6_SALMN/56-167 AC A0A8D0BDU6.1
#=GS A0A443SJR5_9ACAR/55-168 AC A0A443SJR5.1
#=GS A0A565C8C9_9BRAS/22-129 AC A0A565C8C9.1
#=GS A0A8I6AFN4_RAT/23-127 AC A0A8I6AFN4.1
#=GS A0A672QNX4_SINGR/552-649 AC A0A672QNX4.1
#=GS B3RRI0_TRIAD/32-145 AC B3RRI0.1
#=GS A0A7K7UL90_9CHAR/381-455 AC A0A7K7UL90.1
#=GS A0A093Y1T4_9PEZI/72-190 AC A0A093Y1T4.1
#=GS A0A7L3LDX2_9CHAR/23-127 AC A0A7L3LDX2.1
#=GS A0A7N0RIK7_KALFE/21-125 AC A0A7N0RIK7.1
#=GS B0WEI5_CULQU/31-91 AC B0WEI5.1
#=GS A0A6G1CII7_9ORYZ/144-202 AC A0A6G1CII7.1
#=GS A0A8I3W7B9_CALJA/197-302 AC A0A8I3W7B9.1
#=GS A0A087U9I6_STEMI/80-188 AC A0A087U9I6.1
#=GS A0A553NHL8_9TELE/250-342 AC A0A553NHL8.1
#=GS A0A250Y3M9_CASCN/24-129 AC A0A250Y3M9.1
#=GS A0A6P3QXK9_PTEVA/132-238 AC A0A6P3QXK9.1
#=GS A0A8B9QC01_APTOW/47-154 AC A0A8B9QC01.1
#=GS A0A8B6GYI3_MYTGA/21-125 AC A0A8B6GYI3.1
#=GS A0A8K1CLD1_PYTOL/326-432 AC A0A8K1CLD1.1
#=GS A0A835CE02_9POAL/394-508 AC A0A835CE02.1
#=GS A0A6G0ISA8_LARCR/23-130 AC A0A6G0ISA8.1
#=GS G3SQQ5_LOXAF/99-209 AC G3SQQ5.1
#=GS A0A674J3I8_TERCA/24-131 AC A0A674J3I8.1
#=GS A0A4Y2VKU9_ARAVE/16-118 AC A0A4Y2VKU9.1
#=GS A0A8D2GY01_UROPR/22-128 AC A0A8D2GY01.1
#=GS A0A3P9AVI8_9CICH/706-814 AC A0A3P9AVI8.1
#=GS A0A6P6RGT7_CARAU/55-162 AC A0A6P6RGT7.1
#=GS A0A6J0BU17_NEOLC/21-123 AC A0A6J0BU17.1
#=GS A0A8R2H628_ACYPI/671-781 AC A0A8R2H628.1
#=GS A0A1E5VBX9_9POAL/165-280 AC A0A1E5VBX9.1
#=GS A0A7F8REI8_LEPWE/360-463 AC A0A7F8REI8.1
#=GS A0A7L1W3K1_9PASS/256-397 AC A0A7L1W3K1.1
#=GS A0A1S3WCA0_ERIEU/22-128 AC A0A1S3WCA0.1
#=GS A0A7K7Y878_THRLU/87-193 AC A0A7K7Y878.1
#=GS E9GW16_DAPPU/730-848 AC E9GW16.1
#=GS A0A7R8CDR6_LEPSM/396-499 AC A0A7R8CDR6.1
#=GS A0A804KIU6_MUSAM/154-262 AC A0A804KIU6.1
#=GS A0A6P4YCY7_BRABE/20-125 AC A0A6P4YCY7.1
#=GS A0A5D3ADF9_GOSMU/49-158 AC A0A5D3ADF9.1
#=GS A0A4Y2KFB9_ARAVE/332-440 AC A0A4Y2KFB9.1
#=GS A0A372QA24_9GLOM/13-129 AC A0A372QA24.1
#=GS A0A6P7Y1J5_9AMPH/469-576 AC A0A6P7Y1J5.1
#=GS A0A6P8S2P0_GEOSA/30-136 AC A0A6P8S2P0.1
#=GS A0A2Z6SKG0_9GLOM/14-130 AC A0A2Z6SKG0.1
#=GS A0A091JMC0_EGRGA/36-144 AC A0A091JMC0.1
#=GS A0A6I9VFM4_BACDO/24-122 AC A0A6I9VFM4.1
#=GS A0A5N6PHU7_9ASTR/152-260 AC A0A5N6PHU7.1
#=GS A0A8C5BVD7_GADMO/219-329 AC A0A8C5BVD7.1
#=GS A0A7K4TA20_9CHAR/759-871 AC A0A7K4TA20.1
#=GS A0A7L0T445_PODPO/14-122 AC A0A7L0T445.1
#=GS A0A2K6P949_RHIRO/53-139 AC A0A2K6P949.1
#=GS A0A8C6DV31_MOSMO/513-621 AC A0A8C6DV31.1
#=GS A0A7J7CWF6_TRIWF/21-132 AC A0A7J7CWF6.1
#=GS A0A2K6QDF2_RHIRO/30-160 AC A0A2K6QDF2.1
#=GS A0A6P6I7U7_PUMCO/48-136 AC A0A6P6I7U7.1
#=GS A0A4U5V637_COLLU/24-126 AC A0A4U5V637.1
#=GS A0A7L2VG21_9AVES/19-126 AC A0A7L2VG21.1
#=GS A0A372RRF7_9GLOM/13-129 AC A0A372RRF7.1
#=GS A0A8H6L4I2_9LECA/70-186 AC A0A8H6L4I2.1
#=GS A0A7K7PMQ4_ACRAR/131-240 AC A0A7K7PMQ4.1
#=GS A0A1E7FZ03_9STRA/51-153 AC A0A1E7FZ03.1
#=GS N1PSE1_DOTSN/22-116 AC N1PSE1.1
#=GS A0A6J0LHG7_RAPSA/18-126 AC A0A6J0LHG7.1
#=GS A0A8H5D0S3_9AGAR/25-132 AC A0A8H5D0S3.1
#=GS A0A7K5LLP1_VIRAL/27-133 AC A0A7K5LLP1.1
#=GS A0A671TKM7_SPAAU/146-253 AC A0A671TKM7.1
#=GS M0R1N0_HUMAN/53-139 AC M0R1N0.1
#=GS A0A8B9W8F2_BOSMU/208-268 AC A0A8B9W8F2.1
#=GS A0A0C4DGF2_HUMAN/51-158 AC A0A0C4DGF2.1
#=GS A0A1A8B1X2_NOTFU/137-246 AC A0A1A8B1X2.1
#=GS A0A5N5NRH9_9ROSI/134-240 AC A0A5N5NRH9.1
#=GS A0A672I3M2_SALFA/45-155 AC A0A672I3M2.1
#=GS U9T518_RHIID/11-122 AC U9T518.1
#=GS A0A2I0LJN6_COLLI/27-133 AC A0A2I0LJN6.1
#=GS A0A3P8YQB6_ESOLU/49-171 AC A0A3P8YQB6.1
#=GS A0A5F4WHL7_CALJA/5-57 AC A0A5F4WHL7.2
#=GS A0A8C9JF69_PANTA/279-327 AC A0A8C9JF69.1
#=GS A0A6P4ILG3_DROKI/22-121 AC A0A6P4ILG3.1
#=GS A0A0D3H2B0_9ORYZ/1010-1120 AC A0A0D3H2B0.1
#=GS B4R2K3_DROSI/791-901 AC B4R2K3.1
#=GS G2Y458_BOTF4/115-225 AC G2Y458.1
#=GS A0A8J0QM88_XENTR/474-581 AC A0A8J0QM88.1
#=GS A0A671WAD3_SPAAU/707-815 AC A0A671WAD3.1
#=GS A0A0K9NX44_ZOSMR/90-200 AC A0A0K9NX44.1
#=GS A0A443SU02_9ACAR/33-140 AC A0A443SU02.1
#=GS T1HSE5_RHOPR/21-129 AC T1HSE5.1
#=GS A0A482V9G7_9CUCU/21-123 AC A0A482V9G7.1
#=GS A0A6H5GAW6_9HEMI/254-360 AC A0A6H5GAW6.1
#=GS A0A6P6CFE8_PTEVA/28-135 AC A0A6P6CFE8.1
#=GS A0A6I9JQN8_CHRAS/94-197 AC A0A6I9JQN8.1
#=GS A0A811YMD0_NYCPR/63-167 AC A0A811YMD0.1
#=GS A0A6J1SSX7_FRAOC/163-230 AC A0A6J1SSX7.1
#=GS A0A2G2X1J5_CAPBA/311-412 AC A0A2G2X1J5.1
#=GS G1PIR4_MYOLU/478-586 AC G1PIR4.1
#=GS E2L7J9_MONPE/33-155 AC E2L7J9.1
#=GS A0A015JHM7_RHIIW/11-122 AC A0A015JHM7.1
#=GS A0A452G5U9_CAPHI/58-160 AC A0A452G5U9.1
#=GS A0A3B5Z2W9_WHEAT/183-298 AC A0A3B5Z2W9.1
#=GS H2YZB5_CIOSA/4-111 AC H2YZB5.1
#=GS A0A7K4ZFP0_9AVES/14-118 AC A0A7K4ZFP0.1
#=GS A0A4Z2CG90_9TELE/190-300 AC A0A4Z2CG90.1
#=GS A0A4V5NAK3_9PEZI/27-114 AC A0A4V5NAK3.1
#=GS A0A8C9C2T1_PHOSS/21-128 AC A0A8C9C2T1.1
#=GS A0A851NDC3_9GALL/1-47 AC A0A851NDC3.1
#=GS A0A7K6CY10_9PASS/19-126 AC A0A7K6CY10.1
#=GS A0A7K4TCA1_9CHAR/14-118 AC A0A7K4TCA1.1
#=GS A0A8C4NF10_EPTBU/92-158 AC A0A8C4NF10.1
#=GS U9TFB4_RHIID/14-128 AC U9TFB4.1
#=GS A0A7K5SUV7_9FRIN/14-119 AC A0A7K5SUV7.1
#=GS A0A6P8XTW2_DROAB/84-186 AC A0A6P8XTW2.1
#=GS A0A8C6PSQ7_NOTFU/635-692 AC A0A8C6PSQ7.1
#=GS A0A5J9T2A0_9POAL/73-143 AC A0A5J9T2A0.1
#=GS A0A158QBR6_HYMDI/560-660 AC A0A158QBR6.1
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