#=GF ID BTV_NS2
#=GF AC PF04514.20
#=GF DE Bluetongue virus non-structural protein NS2
#=GF AU Kerrison ND;0000-0002-1471-953X
#=GF SE DOMO:DM04350;
#=GF GA 27.00 27.00;
#=GF TC 328.60 78.80;
#=GF NC 22.70 22.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11752140
#=GF RT Localization of the single-stranded RNA-binding domains of
#=GF RT bluetongue virus nonstructural protein NS2.
#=GF RA Fillmore GC, Lin H, Li JK;
#=GF RL J Virol 2002;76:499-506.
#=GF RN [2]
#=GF RM 11162836
#=GF RT Multimers of the bluetongue virus nonstructural protein, NS2,
#=GF RT possess nucleotidyl phosphatase activity: similarities between
#=GF RT NS2 and rotavirus NSP2.
#=GF RA Taraporewala ZF, Chen D, Patton JT;
#=GF RL Virology 2001;280:221-231.
#=GF DR INTERPRO; IPR007602;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family includes NS2 proteins from other members of the
#=GF CC Orbivirus genus. NS2 is a non-specific single-stranded
#=GF CC RNA-binding protein that forms large homomultimers and
#=GF CC accumulates in viral inclusion bodies of infected cells. Three
#=GF CC RNA binding regions have been identified in Bluetongue virus
#=GF CC serotype 17 (Swiss:P33473) at residues 2-11, 153-166 and 274-286
#=GF CC [1]. NS2 multimers also possess nucleotidyl phosphatase activity
#=GF CC [2]. The precise function of NS2 is not known, but it may be
#=GF CC involved in the transport and condensation of viral mRNAs [1].
#=GF SQ 32
#=GS Q2YH50_9REOV/13-434 AC Q2YH50.1
#=GS A0A0K1TPJ8_9REOV/1-360 AC A0A0K1TPJ8.1
#=GS A0A077JI50_9REOV/1-402 AC A0A077JI50.1
#=GS W5QLZ1_9REOV/1-344 AC W5QLZ1.1
#=GS A0A097I4F0_9REOV/1-367 AC A0A097I4F0.1
#=GS U3RAB0_9REOV/1-337 AC U3RAB0.1
#=GS A0A1V0CK00_9REOV/1-352 AC A0A1V0CK00.1
#=GS Q9WAT7_9REOV/2-328 AC Q9WAT7.1
#=GS A0A0H4M5A6_9REOV/1-376 AC A0A0H4M5A6.1
#=GS U5YJB2_9REOV/1-183 AC U5YJB2.1
#=GS M1GUF7_9REOV/1-365 AC M1GUF7.1
#=GS A0A0H4M3U8_9REOV/1-383 AC A0A0H4M3U8.1
#=GS A0A0K1RIB7_9REOV/1-352 AC A0A0K1RIB7.1
#=GS U5YJB2_9REOV/172-312 AC U5YJB2.1
#=GS V9SED0_9REOV/1-371 AC V9SED0.1
#=GS E1AA96_9REOV/1-357 AC E1AA96.1
#=GS H9ZXQ9_9REOV/1-349 AC H9ZXQ9.1
#=GS VNS2_BTV10/1-352 AC P23065.1
#=GS A0A4P8PUV7_9REOV/1-449 AC A0A4P8PUV7.1
#=GS W5QLW8_9REOV/1-338 AC W5QLW8.1
#=GS A0A4P8PUV0_9REOV/1-445 AC A0A4P8PUV0.1
#=GS S6C8V4_9REOV/1-357 AC S6C8V4.1
#=GS A0A0H4M5F0_9REOV/1-366 AC A0A0H4M5F0.1
#=GS M4MJR4_9REOV/1-366 AC M4MJR4.1
#=GS A0A6G9KJ91_9REOV/1-364 AC A0A6G9KJ91.1
#=GS A0A0B5GDD0_AHSV/1-361 AC A0A0B5GDD0.1
#=GS A0A173G2W8_9REOV/1-369 AC A0A173G2W8.1
#=GS U5NGK0_9REOV/1-449 AC U5NGK0.1
#=GS Q2Q1D6_9REOV/1-434 AC Q2Q1D6.1
#=GS A0A4P8PUW9_9REOV/1-440 AC A0A4P8PUW9.1
#=GS A0AAE9CSY7_9REOV/8-395 AC A0AAE9CSY7.1
#=GS H9ZXS8_9REOV/1-368 AC H9ZXS8.1
Q2YH50_9REOV/13-434 ......................MEAKKDsfqlqnqgagnfeRGPRIATRTFVFYCTTSTTSVGKIAKAFGTQYLAVKVGTTTHFEGVNFPIPRCTLITVLGPCAIKVIDRDVTCSFMITETGLEASMNRWAKYKFETVE..TSSRFCKINIGGKMIEESIRVGKATGLVMPYTEEDmMQQEEMDDLPGVEFINLDsdqVQEQREKLKIGREITRD.MIGSALRECGASRSEGRLFGL.......RSDVTAKLQPVkrvtnr..............vqgrleeKPKAPRTPK..GPFQLSRQSSEP...EAMDASQmarlm..................rekltIDTTS-.........GFEDRTESTFLAEKiRer......qllSPv.asPSITAEV................ELSRKKIDSVG-......---SNSPMSAp.pFKLNDTYFELANAI.ASDSsLPTELLPLD..RADPVKLGAFEKLATTFSFSKVGkLPIFNISTHGCEYSYAGYEEVTKAALVISGGNLVVLPV.............
A0A0K1TPJ8_9REOV/1-360 ......................MEHK--.............--PKRFTKNVSVLDGSGTTICGIIAKSAHKPYCNISIGRNVSIKAVDNPPPKAYVLQIRQEGGYRIQDGQDTISLMITASGVEATVERWEEWQFEVLSamPMPMAIMMQHNGEMVDAEIKYAKGMGVVAPYVKNDeVDRRELPKLPGLSESQYD...VKTLRQKIKEERERGVT.EIRSKIQPLEQE--TKRMESV.......-----------...........................EKSFAEMKA..IWAAESKADVK-...--EENVG............................GTYGTD.........FFKPFPIESTKMPElK...........--....SLEQRE-................QQKEKEVAQAQSfs.vdvESGSEEEVEE..pNYITQEYVDKASKV.VKGG.-EKKIAGLA..YVMPKSIGDFSKIIAVKKHKWSN.VPLFTVDEKGLKYELQTIGECETVVYAARGLNLLVLPV.............
A0A077JI50_9REOV/1-402 ......................MEQQNHq..........ksERRQMFTRTFAFYSKDRNNYVGISCAAQGKNYLVVKIGQTTQMCFTDSPVSRGAIIDVRKQCSIRVQDRDQSTFFVISNCSIEWALDRWPRMVFETVD..VHTKFGHLIINEKEVETEFKCGVAHGIVAPYTEEAdQVGEGEIELPGVKFIKIEg.sLREERERLKEMRDEREE.TLTVALKASGSTRAQGRIHGL.......RFDKVIELEKSs........................dvVPQGRAFKRgsSSGSSIEQDVEQ..fGLQNMVQrglkti................tvqnfpG-----.........TSGVQIHNSEQIK-.-...........PPr.mtWADEVEI................ESSKPRTVMKPKti.penLDEVVKVMTLd.ePKFNDNYYKVLNIL.SESPdCAEWLSEAR..IMEPPSTGTYERLATKISFKEVE.LPVYTIDTQTKNFTYNGVGKASSAMVVEDQGVVHIIPT.............
W5QLZ1_9REOV/1-344 ......................MAQEQV.............QVKRKFTRTICVLDPGAKTFCGKVAKLEGKTYFVIKIGRTTQVGVSNTPVPKCYVLDVAGPGSYRVQDGQDTVSVILSESGFEATGERWEEWRFEVLS..ATPIVARMAVGEDEFDAEIKYSKGLGSVPPYAKNE.ADRRMMPTLPGVKALDMP...IRDFRQHAREHRDEVRA.QLDRA--ARRLDPSSSRLLGAs....vgLSEEIP-IESV...........................LPQAKREPV..-VFASASRELD-...DWGFDMQ............................PKTSGD.........----WGA-------.-...........--....-------................KTPIPE-V----......-ESDEGEMND...THITTAFISKCSEA.AKKH.-STTFSGLS..ARVPAASGKFDEVILVKKSAWGD.VPLFRIDEATRKFEFMAIGTSTQVLCVKDDLSYMLLPT.............
A0A097I4F0_9REOV/1-367 ......................MEGKKT.............NVPRLFTKRVYVLDTRKSTICGRISQLAGLPYCKIESGRVVSVTACAQPSDRGYVLEIEGKGAYRIVDGQDTISLMIDDYGVSMTTGRWEEYAFEMVS..VRPHVMKVKEDRVFKNIEIKHGRGCAAVPPYMRVD.REQNSELRLPGTERSDMD...VSTYRQKRREERE----.---------GMDRNTQRLQPAh.....mRSEEMDRSSWSeq.......................vnASKAQ---KydEEFNKFQESVRQ..iELEDEYP............................AGQQDDdnddnfglgLVKDEDNTSQKKGG.-...........--....-------................EEREKKASQQDDf....gLDFEEECAKF...NYLTDTYSELVGKI.VAKN.-LKQLGGKS..MIFPQLGDRYTEKLVVLTKECNN.VPLYNIDEIAKEYRFAAIGTCKRIVMVAKGNSFTALPA.............
U3RAB0_9REOV/1-337 ......................MEQRTQ.............-LRRVFPKTVCVLDPKGETICGMIAKSQHKPYCLVRTGRVICLKAISQPPPKAYVLEVVKCGAYRLIDGQDQISIMLNKDCVEMTSERWEEWQYEMVS..IKPMVVSLQLEYGVVDAELKYGKGFGSVEPYKKNE.LERGEVPTLPGVQQSAVG...LRELRTKLKKEREEKVQ.--------------------G.......RSVELPTMKKV...........................NVQAEQGFEwsAVREKVVEMEEEi.kDWAEH--............................------.........--------GSSEEE.-...........--....-INDK-Q................QTDDEEVVKDDD......DEATEEGLVKv.dSFITGDYVNYVSGM.SKKK.-DERLSGLS..LSFPKIEGEFEKVLCIKKTEQTG.FPVFEVDQATKTFRFRMIGKCDRVFVVKRSMSMVYLPA.............
A0A1V0CK00_9REOV/1-352 ......................MEQK--.............--QRRFTKNIFVLDANAKTLCGAIAKLSSLPYCQIKIGRVIAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISLMLTPHGVEATTERWEEWKFEGVS..VTPMATRVQHNGVMVDAEIKYCKGMGIVQPYMRND.FDRNEMPDLPGVMRSNYD...VRELRQKIKNERESAPR.-LQV---QSVAPREESRWMDD.......DEAKVDEEAKE..........................mIPGTSRLEKlrEARSNVFKEVEAg.iNWNLDEK............................DEEDRD.........EREDEEQAKT----.-...........--....-------................------LSDDDEq....gEDTSDDEHPK...THITKEYIEKVAKQ.IKLK.-DERFMSLS..SAMPQASGGFDRMIVTKKLKWQN.VPLYCFDESSKRYELQCVGACERVAFVSKDMSLIILPV.............
Q9WAT7_9REOV/2-328 ....................gd------.............--RKRYTKTVCVYDPQNATFCSRGANA-GENYYQVKIGRTTQITRTNAPNPKAYVVEIQRPCSVRLLDGNDIISLIISEEGIEVTTERWEEWLFEALT..PIPMVISLHIKGQKTEAEIKYCKASGVIAPYTPNE.VDRRITPQLPGITFTDVS...VRDFRQKMREEREKEKE.---------------------.......---RTPMITPI...........................KPKTEAPVMgpSTSQQYQKEES-...-----IA............................VGKISD.........YVKKVKLES-NVER.-...........--....-----DS................DDEDEH-GSNSD......SDFDGEPKDE...GYITQNYMNMIETV.KMKV.--PGVAGLT..LKIPKAAGKTDGMIAAKKCKWIS.VPLFNIDKDGLSYDFVAVGDANGFLCLRDGLSYLVLPV.............
A0A0H4M5A6_9REOV/1-376 ......................MASQDSr..........vpMIRRPFLRTISIHSTGTDDYVSKTCHVMKGSYLIVKQGMGSQQVVSDTPATGGMVLVIPGPGSYRLLDRDQSTFIIVDVNGIEVMPDRWPGFCFETVD..MSAHSATIDVGSEEVPGIVSYGRAAGTIPPYTPDG.NGPTNTITLPGIKFVKSDe.pMRELRVRLKEEREEHAT.KITRAVRALGASRAAGRALGV.......RAEDLSGLT--...........................PPVRESLSF..SSSTSIRPSPTT...SFTPVTR...........................pA-KPMA........sSTPPPPPVTPLATR.P...........AP....PSAALQK................MAPVPAVKTAPA......----PPVTDT...ITFGPDFNALLEEM.AQGVmREVPDASFS.sLSAPGAVGYYSDDFGVFSIPATT.LPAYTFDATSQKYEYTGVRSVTSVHAVASDGVLYAVPE.............
U5YJB2_9REOV/1-183 ......................MESK--.............-PKRVFTKTVCVLDAYGKTFCGNVAKLCNKPYCLIKIGRVVSIEAVDNPRPKSYILQIEQVGSYRIQDGQDNISLIITNQGVEATVERWEEWKFENLS..PIPMATMIMVADKRVDAEVKFVKGMGIIAPYTKNE.MDRRDVPDLPGVMPSSMG...VKELREKLRNEREQGK-.---------------------.......-----------...........................---------..------------...-------............................------.........--------------.-...........--....-------................------------......----------...--------------.----.---------..-----------------------.--------------------------------------vreseivrpavvn
M1GUF7_9REOV/1-365 ......................MEDKRE.............-RPRVYTKTFLLYSQDEGNFVGKICRAMKAVYYAVKVGQTTHMCVTDDPVPQAFVISIGSEGAYRVIDRDESVYFMITGDGVEVATGRWPKYQFESVD..VVPRFCSITVKGQEVETELKVGRGVGNVKPYTELMaIKTEGVCELPGIKFLNIEg.dVREARAKLKEERGQRDE.IILTALKESNADRGIARFMGL.......RNDKVMLLENVski.....................evgS--------..-PSRRIQTPRAVt.pI-----Saf.......................tpiVPQQSK.........TVILPESTAAMYSA.-...........MS....GISKVDV................TYKEPLSVDVGS......----------...DFFGDEYRRLVHAL.EAHPdVRNSHESVS..FAMPTRMSSFENTMFEMKTQLNN.VPLYQLDTARSEYKYLRNGVSSKVVVVLQGGQLVALPE.............
A0A0H4M3U8_9REOV/1-383 ......................MAAEQP............kMIRRPYTKVLAIKSSG-TDFVAQMCKALSREYLVVKHGMNTQIVGADAPPPKAMLLLIPHEGAFRLLDRDQSFFVMVDRDGIEVTQDRWPGMRFETID..LMTRGVELMIAGQPITTEVRYGVAAGLVPPYVPDEsRSKEDEPEFPGVKFIEVEg.gMREFRERLKEDAEIRAS.ALTSALHEAQSTRCLGRLMGM.......RNADLGRLRIKe.........................mPPRPRAH--..TSHEVIAVPASE..tRVL----............................------.........APPPPPPNRPALTRlAa.........fEP...iQTKTTAApppprpl..vlpvtrdS-----QASTPS......TRSPSPALVT...GSSAALYDELVQKAySSLVqREPELADFT..PQHPERVGLFSKDLGSYSIDPIA.TECYTVDTLKCRFSRGGVAEATRLRVLVNDDRVYFIPE.............
A0A0K1RIB7_9REOV/1-352 ......................MEQK--.............--QRKFTKNIFVLDVNAKTLCGVIAKQSSQPYCQIKIGRVIAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISIMLTPSGVEATTERWEEWKFEGVS..VTPMATRVQHNGVMVDAEIKYCKGMGIVQPYMRND.FDRNEMPDLPGVMRSNYD...IRELRQKIKNEREMAPRpQIQSA-----APREESRWMDEde...arVNEEIKEAASS...........................VGRLERLRE..ARTNMFREVEAG..vSWNLDHQ............................SEEEAD.........GDEDGDHANHQADE.-...........--....-------................--------DEQG......EDASDDEHPK...THITKEYIEKVAKQ.VKLK.-DERFMSLS..SAMPQASGGFDRMIVTKKLKWQN.VPLYCFDESTKRYELQCVGACERVAFVSKDMSLIILPV.............
U5YJB2_9REOV/172-312 reseivrpavvnhvveqpkwed------.............--------------------------------------------------------------------------------------------------..-----------------------------------.------------------...-----------------.---------------------.......-----------...........................---------..------------...-------............................------.........--------------.-...........--....----LDTkiaa........vtdwNADVPSEIPHGS......S-EEEEEEGG...EYLTGKYMKKVSTI.VKNP.-DPSVLGMA..FGYPKTSGPFDRIIVEKECLWTG.VPIYDVDQTDKSYRLVMIGEATKYLLAVKGQNYFVLPA.............
V9SED0_9REOV/1-371 ......................MEQK--.............--QKRFTKNVFVLDQKRKTICGQIAARQSLPYCQIKIGRNFALRAVATPEPKGYVLEICDVGAYRIQDGNDVISLMISVDGVEGTQERWEEWKFETIS..CVPMATILNINGALVDAEIKVSKGMGIVPPYTRND.FDRRELPELPGVQRSKYD...IRELRQKIREEREKGAV.--EQ---PHKPTFKTERWHEQ......pDSDEDQNPASGvvnd..................wtcetQKRDQ----..---EAERREALE..iRLAEQRQ............................-----Ri......eaFKFDSERRREDLER.S...........QEq..fRTQEVERk..............kSDMGEVIIEEDD......EDSEEEEGAR..aSYITSAYIERISKI.RKIK.-DERLSMLA..SMMPQQSGEYTTILFIKKQKWDN.VPLYLIDEMQKKYELQSVGSCERVAFVSKGTNLIILPV.............
E1AA96_9REOV/1-357 ......................MSADKQi...........pMIRKPFTRTIVLKSTGKDDYVAKMCNALGCEYLVVRHGLGMHVAGSNTPTHGCMLLLIPGAGSFRLIDRDQSTFVVVSSDGLEVQQDRWPGMRFEAVD..MFPRCCRIVVGDVAADSEIRFGSASGTVPPYTAGEsMEAQDEISLPGLDFSVPDs.dLREYREKLREEKEERAA.AILSALRTTQQSRTLGRLHGV.......KTSDLVTLR--...........................PPQPPTPGR..NGHSALMSSAPV...-------............................------.........-PPPLVPTSSSTG-.-...........SP....ALSTTGLkr............tqKLAPPPVAES--......--------AG...PTFGADSNRFIEEA.LEAVmQDDASGRLN.fGGEPESVGLFSQNLGSFDIPPSQ.LPAYEIDETRNKYKYVGMRTSTRLHALACDDRVYFVPS.............
H9ZXQ9_9REOV/1-349 ......................MESK--.............VVKRVFTKQICVLDPGCSTICGKIARESKCPYTQLKTGRIVGFQAVRSPPPKAYILEITKPGAYRIMDGQDQISIMVEEYGVEITTDRWEEWKYEVVT..AMPMTALVDTPRGKVDAELKYARGTGLVPAYTRNE.FDRRELPTLPGVGVSEIS...VRDLRAKLKAERTAD--.-IPRA-EHKEEKKKNVRENTS.......VFDVSEMLKKV..........................eEMRSE--ER..SWSDEMEDEVEG...---EAAD............................VNEQTD.........-ALWEDEVTESVEE.-...........--....-------................----PDKANLED......IAEEEEPFNA..tNFVTDGFVANVSTY.MKSG.-DKRIVGLA..SSFPKSAGSFDSVVCVKKACWMN.VPLFDVDVGKKGYGLRMIGDSAKLYIVKRGLSVMVLPA.............
VNS2_BTV10/1-352 ......................MEQK--.............--QRRFTKNIFVLDVTAKTLCGAIAKLSSQPYCQIKIGRVVAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISLMLTPHGVEATTERWEEWKFEGVS..VTPMATRVQYNGVMVDAEIKYCKGMGIVQPYMRND.FDRNEMPDLPGVMRSNYD...IRELRQKIKNERESAPR.-LQVH---SVAPREESRWMDD.......DEAKVDD----...........................EAKEIVPGT..SGLEKLREARSN...VFKEVEAvi.......................nwnLDERDE.........--GDRDERG-----.-...........--....------D................EEQVKTLSDDDDq....gEDASDDEHPK...THITKEYIEKVAKQ.IKLK.-DERFMSLS..SAMPQASGGFDRMIVTKKLKWQN.VPLYCFDESLKRYELQCVGACERVAFVSKDMSLIIC--rs...........
A0A4P8PUV7_9REOV/1-449 ......................MEAKKEit.........feKGPRTLTRTFVFYAPSGNSFITKLSKALGTQYIAIKTGASTHIEGVNVPVPRSTVIALSGPCAIKIIDRDVTTFFMISENGFEVRQGRWGAYKFELVE..TVGRFCKMQIGGECVEESIRMGRPACNVPPYTEEEsFEGGITMELPGISFVTVEseeLAEKREKLRVEREVRRD.LFGVALKEVGATRGMGRLFGV.......KPEVTASLQTVkkvttr..............aqtkgddKPKPQRVMR.mSSGAGKSESESGdpsKIA---EilrakqvseqkmegafemevkmesferrVEETDRpsrlptpssMVSTPSEVVMMLEKmRvgsge.gatgySPlmksPTPTAETl..............mHLPKPRSSEGPS......--SLHSPFSM...FKLSEEYKNLAETI.HQEY.CEGEGSSLD..LEMPLKLGSFEHILLTCNFPKGGlLPIFNVNSSSCEYNFAGFESVNKAILVSSGGSLVVLP-i............
W5QLW8_9REOV/1-338 ......................MAQE--.............-VKRKFTRTVCIYDPQNRTFCGRSAAMVCNSYYTIKMGRTTQCGVSPVPVPKSYVLEIPDVGSYRILDGQDSISVIVTETGVEATSERWEEWKFEGVN..CVPMVVQTEIGKGLIDMEIKFSKGMGLVKPYVKNE.VSRTEIPRLPGASVIDTP...IRDYRQLLKDQRDERRA.ALDAI--ACDICPTLSRMLGA......nITDGSPQVEEV...........................ATRPTQPPA..QLKLDVPNWDQ-...-------............................---PTD.........-SDDED--------.-...........--....-------................-EESKRVTTQSN......ADTEEQVTFE...DCITDQYFSKTGEF.AKKY.-PEMLAGLS..AKMPSETGRFTKILTTRKAQWNN.VPLFELDPNGFTYHFSKLGNSTRIFCVQRDLSYMVLPA.............
A0A4P8PUV0_9REOV/1-445 ......................MEQKRDqq.........npERSRPTIRTFVFYNPANNTFIGRTAAALKCQYLAIKVGPSTHIEGVNVPVPRATVVMVSGPCAIKIIDREVNTFFMISENGIEARQGRWPNYKFESVE..TANRFCKMIIGGETVEETVRVAKPSCTTPPYVEEEmVETGESLSLPGISFLNLEsdeVPEKREQLRVEREKKKE.VFGKVLGEMGATRGMGRIFGL.......GYEATSRLQTVkrittrvqgki....eekpkpqrvveeKVKTQRLSR..SPFSPPLKCEPE...-SDDPVKvaemirskml........qeqkaemvyeVEEKSEvs.....aiPVAAIPDVNTMLERmRsttae.shsefVPivktPTQTTETlahl.......rtpkhQEASPLLMHSP-......-------VSS...FKLTDEYLQLAGII.HAEV.TGSEIAVGE..LTMPLKLGAFEKIVTTYNFQRMGpLPIFNVNMTTCEYTFAGFEIVSKAMIALSGGCVVILPV.............
S6C8V4_9REOV/1-357 ......................MQTEKM.............EKPRRFTRTVCILDRTENTYAGKVSRMMKNPYFIIKAGRSVVTGTAPFPPPRSTVIEVSDECAVAIQDGTDVTYIQLTRETVELCVERWNEYKFETLN..PTSNVGRINIGGSDVLGEIKYAKAQSLIRPYTRNA.SRSSDMPNLPGLTPTDID...VRTHRDEDRKNREEGRA.RLENALRGANLG-ASSRLFGV.......--DAAPCID-V...........................PVRTLEIQK..-----PDLGRSQ...DWN----............................------.........LSFDSNPGSRSMSPlS...........THy..tGLKKVEP................ERPSPFMVQEDS......LEQDEEP--L...DVMTSQFIKLNSDF.SKAYgTSPMLSSLT..QKLACKSMKFEKFVTNVMINSEN.VPLFTIDQSSGNAVLKGMGECSSAAVVVSGGSYFVLPA.............
A0A0H4M5F0_9REOV/1-366 ......................MAESAQ.............--KRTFTRTVVIYSKGEHDFVARMMKSMAFPYLLIKIGQSVQLLGCKVPPPRSWLVEIHKEGSYRLVDRESSVYLVVSADGVEVQQDRWPRLCFETVD..LRARFCEMTVGSSELQSEIKFGVGKGYVAPYTEESdTGNDQQIILPGIRLIRISg.dAREFREKLKEERDTRDR.IIVEGIRATGGTRCTARAFGI.......RFDRMQRIDGEf........................dePPRPTTPRR..SEAPPPPHNA-P...-------............................------.........FVTMIPEPARQNS-.-...........SP....PLPSLDIr..............eSKKRPSVARADE......-TRPQILT-VpayRPPDDPMEQLLLEM.EKLQgETPDLSNYI..MTLPNRVGSYDRVFGTVQIAPTH.LPTYRLNDGSREYERVGDAVVTSVGLAICGHQVIILP-g............
M4MJR4_9REOV/1-366 ......................MSSDKQn..........vpMIKKPFTRVIVLKSDGRDDFVAKMCAVLGCEYVVVRHGLGTQIAGSDTPAHGCLLLTIPGPGSFRMIDRDQSTFLVVSGDGLEVQQDRWTGMRFEAVD..MYPRACRIRYGEKENDSEIRFGRASGTVPPYTPDGvSEEQEEVALPGISFHTPEe.dYKEYRERLREERDLRSA.NILEALRTTHQSRTLGRIHGI.......RNSELTTLR--...........................PPAPPTLRR..GVSSSNERSADR...T-PTPPK............................LTAPT-.........---YPTAAAPRAAA.A...........PP....PIPSVKR...............vSKTAP-------......QEAESQC---...PKFTHEYDQLAERA.FESLlEDDPNARFS.yGGAPETVGLFSQCLGTYEVDPLM.LPAYEIDQTKNRYKYVGMKTSSQLNALVCDDRVYFVPS.............
A0A6G9KJ91_9REOV/1-364 ...........mstsntdtssp------.............LRKIIYTKTLVILDRSGSTFCGKIARLENKQYCVVKIGRSVQISASDVPPPKSYILDITQAGAYKISDNQNVIMTMIDTDSIEVCLDRWDEWCFESIN..AIAYPSMINIDGQMIDTELKICKGAGLVPPYTSLD.FNRRDVPELPGVQTLDVR...MSDHRAKLKDQRDLLRQ.KMDTAM-DSKMSKSTQRLFGA.......---QMHKPLAS...........................TSRDKDI--..-VFQKVKNSTDV...EIEM-MW............................DENPAE.........YITDVVPSMSTIES.-...........--....-------................----EQLVDGADdwgdyvDEEPEKPILNe.gAPVTVEYQREMEKV.MNAP.-PRRAAGMC..FGYPSESGQYDTVLFEGLKVWND.VPLFVIDPELKKYSFLRVGSSARVLGVKAGGVALLLPA.............
A0A0B5GDD0_AHSV/1-361 ......................MAEV--.............RKQQQFTRSVCVLDLGEKTYCGKVVRAVNGVYYTIKIGRTVQCGVTPTPIPKSYVLEIRECGAYRIQDGTDVLSLMITESGIEVTQNRWEEWSFEALT..PVPMAVAVNVGRGSFDTEIKYVRGSGAVPPYTKNG.MDRRAMPSLPGITTLDVG...VRDLRLKMKENREAERE.KMERAL-SGGLDMGSCRMYGG.......GRNDVREITLD...........................EAGPSRTPR..KLSVQSNESRSD...D----VA............................-RRHAE.........L-VEMERLR-MMKN.-...........EP...vRTESMWC................QSDSDDQSDED-......-HEVGSTEPE...NYITEEYTRRLNEV.KTKY.-SKELSSLA..MRVPKNEGNCGKPIFSKKCKWEN.VPIYNYDEASGNYRFVSVGSATHYHCCANDLSYMILPA.............
A0A173G2W8_9REOV/1-369 ..................maht----LEa..........vtRERRRFPKTFLFWSDDESNFVGMMSKVTGKPYLAIRTGMTTQVSMMDYVVPRASLVEILSCGSYRIQDRDEATFFVISEHGIEVAPERWPKLLFETVD..LQSRFCEINVGGDLVKTDVKYGRGHGTIAPYTEEAdSSTDSDIHLPGISFYRVEg.dVREERERLKNAREEREE.KILTALIEAGGTRSEGRMLGL.......KFDKIANLQIS...........................GEHEKRKPK..--LKASRKDESE...KIKEWPD............................VDSSDD.........---DPKIGIQLGHE.R..........pKP....KPA-RRSs.............tdDTAEPKEIQN--......--------EQ...GQAKDNWKKLATSI.MKMKtIKEDAAGLK..VVEPAHTGVFDSIMTSVSFDSVC.VPTFKVDSHAKEYSRTGYALSKRAHIVISGETLTILPE.............
U5NGK0_9REOV/1-449 ......................MESQRQpra......qsgdRVTRTPIRTFILYSTTEDNFVGRICKTLHTQYLAVKLGVSTHIEGVNTPVPRSTVVTITGPCAFKVVDRETTCHFMISATGIETRIGRWAQYKFETVE..TRSRFCKMEIGGQSVDEMLRLGRATGSVLPYTEEEmMGGDEDVDLPGVKIVSVEnedVPNLREKMKMERQTKRD.LIGMALKESGATRGEGRLYGA.......RPETMAKLQSVkklttriqgkqekldrslksdeacldlKPKMQRPSR.iSSFSPVTKDSSV...IADEEAAeaspati.............aklmrqhsITDQAP.........IAKMITDEVSIIETaSladklrksaqsT-....------PlhfspimsggfsdldiSTQKIKVQEIP-......--ASPQLAQA..vFKLNEEYKTLSAIV.HQDErLPPELSMLE..LGTPVKMGAFERVATTYNFSSGGmLPVFNVNTSSNEYKFVGFERVSRAVVVISAGAILVLPV.............
Q2Q1D6_9REOV/1-434 .......mdqkrenftgqnqmq-----Mqn.........adRANRVLTRTFSLYSLNNNNFIGKVTKCMNAQYLAVKVGITTHFEAVNVPPPRSTVITVSNPCAFKVQDRETTTHFMISESGLEACLGRWSKYKFESVD..TTSRFCKMSIGGQTVEETIRVGKCLGIVQPYTEEEmMDIGEGIELPGISFVNLQseeVAEFRSKLRVERDMKRD.LIGVALKESGAARSEGRLFGL.......KLEATAKLQPMkkltar..............iqskteeKPKVQRTVK..SPFSPISTKNEM...EFVENTSlkmmrskt............nsevslekID----.........-DHSTNEAVLQAEKmKlamge.srmvsSPv..tGIAGLEA................TMTLMNIHKPNDv...piATSPLMVVPS...FKITEEYRELTATI.QMDPsLPAELSVLE..IAAPGKMGSVEKIATSFSFHANTmLPVFNVNSSTCEYKFAGYDKASRAILAVSAGCLVILPV.............
A0A4P8PUW9_9REOV/1-440 ......................MEQKREgq........terSGPRFMTRTFLFYSKNDSTFVGKVCKALGMQYLAVKVGGATHIEGVNVPLPRATIIMVGQPCAIKIVERDVTTYFMISETGIETRQGRWGNYKFENVE..TTSKFCKLQVGNETVEESVRIGKASGVVQPYTEEEmADVDLDLELPGLSLMNLEsdqVSEMREQLKAQREQRRT.VLGSALKEIGATKGLGRLVGV.......RPEVSAQLGAVkkltgr..............vqgkmeeVPKPQRLLK..SPFGPITKMEAKpeqKLDEPARiaevlrmksqlq...aqlhapvppvdtlVELE-Dk.......pVLASASDITTLLERmKtpvte.vasgfSPi..mKIPATESpvtp.......fkpkkMEASPSIMQSP-......-------IQG...FKLNDEYLTLADSV.HKEC.LSSDIGPAE..MSLPLKLGSFEKCITTYSFPRGGlLPIFNVNLTSCEYAFAGFEAVNKAMIVSSGGSLVILP-i............
A0AAE9CSY7_9REOV/8-395 ......................MEKKSD.............-SKPRYTRTLYVIDRDRQTLCGKMASMEMKPYTVLKIGRTVHISTSAELSHRAFILDVSRPGAYKIIDRDVTVSVILTETSIEASTEPWNDFTFEMVD..ARPVPATTSVGGFHVPIEVKHCIGRGIVPPYTSVD.RVSLGDLQLPGLEIVNLT...IAEQRAMIKERRDEISA.QMAMA--TDDMSESDRRLFGIyrrrqqgQDNEVKQPMSL...........................GPKPKDPAG.fAAKEKISSDVQT..sQFGD-VQ............................VHSDDEdae..svgsGSEDENEAATIVEE.Q...........--....QQVDLKF................EKAIESITMTDDer..kgARKKVQPTPEa.dAHLTPAYKLLFEEM.TRVP.----IAGLNepFGMPGTSGKITSIQKNYISSHSN.VPLYKINQKKATFQFTNIGDAGRVVIVLSGGRACLLPT.............
H9ZXS8_9REOV/1-368 ......................MEQK--.............--PRRFTKTICVYDPSGRTICGKVAKEKRDPYAIIKLGRVFSLKSADGPQPKSYVLEISRPGAYRIQDGQDTISLMIEENGVEGTTERWEEWKFETLN..PMPMATMIRHNGQMVDAELKYCKGMGMIEPYTKND.FDRKEMPALPGVEQSKYE...VRELRQKIREEREAQAK.-------------------GL.......----LPQPRDM...........................RVREEEQMQ..RAQEVVRQEKTS..yKWEDDID............................FDQPKDt.......qVRKDFDEERHRQEQ.Raqrrn.eqnerDEelhrKLEAFEQni...........lnkAEKMEQIVEEVS......EESEEEEVVE...SYITAEYIERMSKQ.QKTK.-DERFMSYA..QMMPQAQGDFDRILVTKKVKWDN.VPLFIVNESRKAYELQAIGECVRVVFAVKGTNLLILPA.............
#=GC seq_cons ......................Mppc................hpRhFT+TlslhsssppTasG+lu+hhspsYhhlKlGpssphpssssPsP+uhllplstsGAaRl.Dtpssh.lhlopsGlEssp-RWtcapFEsVs..shshssplplsuphV-sElKau+uhGhV.PYTcs-.hcppphspLPGlphhsh-...l+EhRpKl+pEREpptp..lt.u..ttths+s.uRhhGh.......t.pphsplp..............................s+spp..p..tshpthppstp....th....t.............................t..tt............s.stts..hpt.......................ht.................ptt..phsptsp.......pt.tp.hst...shlTspYhphssph.tpth..spphuuls..hshPppsGtF-chlsshphphss.lPlaslDpsspcYchtuhupss+shhVhputslhlLPs.............
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