GenomeNet

Database: Pfam
Entry: Bacteriocin_IIc
LinkDB: Bacteriocin_IIc
Original site: Bacteriocin_IIc 
#=GF ID   Bacteriocin_IIc
#=GF AC   PF10439.12
#=GF DE   Bacteriocin class II with double-glycine leader peptide
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Manual
#=GF GA   27.10 27.10;
#=GF TC   27.10 27.10;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0400
#=GF RN   [1]
#=GF RM   17074857
#=GF RT   The blp bacteriocins of Streptococcus pneumoniae mediate
#=GF RT   intraspecies competition both in vitro and in vivo. 
#=GF RA   Dawid S, Roche AM, Weiser JN; 
#=GF RL   Infect Immun. 2007;75:443-451.
#=GF RN   [2]
#=GF RM   17298586
#=GF RT   Diversity of enterococcal bacteriocins and their grouping in a
#=GF RT   new classification scheme. 
#=GF RA   Franz CM, van Belkum MJ, Holzapfel WH, Abriouel H, Galvez A; 
#=GF RL   FEMS Microbiol Rev. 2007;31:293-310.
#=GF DR   INTERPRO; IPR019493;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of bacteriocidal bacteriocins secreted by
#=GF CC   Streptococcal species in order to kill off closely-related
#=GF CC   competitor Gram-positives. The sequence includes the peptide
#=GF CC   precursor, this being cleaved off proteolytically at the
#=GF CC   double-glycine. The family does not carry the YGNGVXC motif
#=GF CC   characteristic of pediocin-like Bacteriocins, Bacteriocin_II
#=GF CC   Pfam:PF01721. The producer bacteria are protected from the
#=GF CC   effects of their own bacteriocins by production of a specific
#=GF CC   immunity protein which is co-transcribed with the genes encoding
#=GF CC   the bacteriocins, eg family EntA_Immun Pfam:PF08951. The
#=GF CC   bacteriocins are structurally more specific than their
#=GF CC   immunity-protein counterparts. Typically, production of the
#=GF CC   bacteriocin gene is from within an operon carrying up to 6 genes
#=GF CC   including a typical two-component regulatory system (R and H), a
#=GF CC   small peptide pheromone (C), and a dedicated ABC transporter (A
#=GF CC   and -B) as well as an immunity protein [1]. The ABC transporter
#=GF CC   is thought to recognise the N termini of both the pheromone and
#=GF CC   the bacteriocins and to transport these peptides across the
#=GF CC   cytoplasmic membrane, concurrent with cleavage at the conserved
#=GF CC   double-glycine motif. Cleaved extracellular C can then bind to
#=GF CC   the sensor kinase, H, resulting in activation of R and
#=GF CC   up-regulation of the entire gene cluster via binding to
#=GF CC   consensus sequences within each promoter [2]. It seems likely
#=GF CC   that this whole regulon is carried on a transmissible plasmid
#=GF CC   which is passed between closely related Firmicute species since
#=GF CC   many clinical isolates from different Firmicutes can produce at
#=GF CC   least two bacteriocins. and the same bacteriocins can be
#=GF CC   produced by different species.
#=GF SQ   99
#=GS Q8DWB6_STRMU/1-76         AC Q8DWB6.1
#=GS A0A139WTX4_9CYAN/1-70     AC A0A139WTX4.1
#=GS D9SPP3_CLOC7/1-70         AC D9SPP3.1
#=GS A0A1I1FJW3_9LACO/1-57     AC A0A1I1FJW3.1
#=GS B9DTX8_STRU0/1-88         AC B9DTX8.1
#=GS A0A5C5TCW4_9STRE/1-50     AC A0A5C5TCW4.1
#=GS A0A085HK04_9GAMM/1-59     AC A0A085HK04.1
#=GS Q5FI73_LACAC/1-64         AC Q5FI73.1
#=GS A0A2L0D506_9STRE/1-63     AC A0A2L0D506.1
#=GS A0A139NEU2_9STRE/3-63     AC A0A139NEU2.1
#=GS B7GL23_ANOFW/1-65         AC B7GL23.1
#=GS L0KCR9_HALHC/1-56         AC L0KCR9.1
#=GS G5JMJ7_STRCG/7-60         AC G5JMJ7.1
#=GS Q8DSB5_STRMU/7-81         AC Q8DSB5.1
#=GS A0A4U1B4N5_9GAMM/1-58     AC A0A4U1B4N5.1
#=GS I0XAR7_9SPIO/63-123       AC I0XAR7.1
#=GS Q8DWB7_STRMU/1-63         AC Q8DWB7.1
#=GS A0A383U1V8_9FLAO/1-51     AC A0A383U1V8.1
#=GS R2SSJ5_9ENTE/1-56         AC R2SSJ5.1
#=GS T1ZF07_STRIT/6-72         AC T1ZF07.1
#=GS A0A172Q9E3_9STRE/1-41     AC A0A172Q9E3.1
#=GS A0A1M5QU07_9FIRM/1-73     AC A0A1M5QU07.1
#=GS A0A1K1P8M8_9GAMM/1-66     AC A0A1K1P8M8.1
#=GS A0A172Q613_9STRE/6-66     AC A0A172Q613.1
#=GS A0A380KA75_9STRE/5-72     AC A0A380KA75.1
#=GS A0A437STT6_9LACO/1-62     AC A0A437STT6.1
#=GS Q8DSA2_STRMU/6-59         AC Q8DSA2.1
#=GS I5BT60_9BACT/1-79         AC I5BT60.1
#=GS A0A6A0BAV4_9LACT/2-53     AC A0A6A0BAV4.1
#=GS J0VAD1_STREE/6-84         AC J0VAD1.1
#=GS B7GL22_ANOFW/1-86         AC B7GL22.1
#=GS Q8DW08_STRMU/1-66         AC Q8DW08.1
#=GS Q1WQX8_LACS1/1-65         AC Q1WQX8.1
#=GS L0KBX3_HALHC/1-64         AC L0KBX3.1
#=GS A0A346NQ03_9ALTE/1-86     AC A0A346NQ03.1
#=GS J0V0Y6_STREE/1-49         AC J0V0Y6.1
#=GS Q5M2W2_STRT2/6-69         AC Q5M2W2.1
#=GS A0A553GSH8_9BACT/1-54     AC A0A553GSH8.1
#=GS A0A139NHC3_9STRE/1-58     AC A0A139NHC3.1
#=GS A0A0Q0H9K4_9GAMM/1-66     AC A0A0Q0H9K4.1
#=GS W7CPH2_9LIST/1-57         AC W7CPH2.1
#=GS Q8DRN0_STRR6/6-65         AC Q8DRN0.1
#=GS A0A347WMH6_9LACT/1-58     AC A0A347WMH6.1
#=GS A0A673YBB6_SALTR/227-304  AC A0A673YBB6.1
#=GS A0A673YBB4_SALTR/227-304  AC A0A673YBB4.1
#=GS D9SSI4_CLOC7/4-70         AC D9SSI4.1
#=GS Q8DS95_STRMU/6-72         AC Q8DS95.1
#=GS A0A4Y9F9Q7_9STRE/1-62     AC A0A4Y9F9Q7.1
#=GS A5CZV1_PELTS/2-61         AC A5CZV1.1
#=GS Q8DSB1_STRMU/10-94        AC Q8DSB1.1
#=GS A0A437SU16_9LACO/11-85    AC A0A437SU16.1
#=GS G5JMJ6_STRCG/6-59         AC G5JMJ6.1
#=GS A0A1H1YFL4_9BACL/1-82     AC A0A1H1YFL4.1
#=GS A0A139NEK0_9STRE/1-72     AC A0A139NEK0.1
#=GS A0A1I7JF40_9FIRM/1-74     AC A0A1I7JF40.1
#=GS Q1WQX7_LACS1/2-62         AC Q1WQX7.1
#=GS A0A1A9HNN2_9BURK/1-62     AC A0A1A9HNN2.1
#=GS J1P4N6_STREE/6-65         AC J1P4N6.1
#=GS A0A380KA66_9STRE/2-55     AC A0A380KA66.1
#=GS A0A4Y9HE79_9BACL/3-53     AC A0A4Y9HE79.1
#=GS A0A380KBI2_9STRE/1-76     AC A0A380KBI2.1
#=GS A0A145WNP8_9GAMM/30-71    AC A0A145WNP8.1
#=GS Q8DSA3_STRMU/1-62         AC Q8DSA3.1
#=GS T1ZF04_STRIT/6-65         AC T1ZF04.1
#=GS M9L947_PAEPP/1-82         AC M9L947.1
#=GS A0A172Q637_9STRE/6-62     AC A0A172Q637.1
#=GS T1ZF76_STRIT/6-75         AC T1ZF76.1
#=GS A0A1E5G4L8_9BACL/1-55     AC A0A1E5G4L8.1
#=GS A0A1G6X8W7_9GAMM/1-57     AC A0A1G6X8W7.1
#=GS F9HJ90_9STRE/1-56         AC F9HJ90.1
#=GS A0A673YB45_SALTR/225-302  AC A0A673YB45.1
#=GS W7CGP1_9LIST/1-68         AC W7CGP1.1
#=GS A0A4Q1SLZ3_9BACL/1-64     AC A0A4Q1SLZ3.1
#=GS A0A1M5QU89_9FIRM/1-76     AC A0A1M5QU89.1
#=GS A5M6F3_STREE/1-75         AC A5M6F3.1
#=GS A0A2L0D508_9STRE/1-69     AC A0A2L0D508.1
#=GS I5BT61_9BACT/1-71         AC I5BT61.1
#=GS F5IUS8_9BACT/1-57         AC F5IUS8.1
#=GS D9SR35_CLOC7/1-57         AC D9SR35.1
#=GS A0A4Q7PJR5_9FLAO/1-62     AC A0A4Q7PJR5.1
#=GS A0A371QME9_9BACT/4-68     AC A0A371QME9.1
#=GS G6ERX6_STRTR/6-68         AC G6ERX6.1
#=GS A0A1X1Q5U5_9FIRM/68-131   AC A0A1X1Q5U5.1
#=GS A5M6F0_STREE/6-63         AC A5M6F0.1
#=GS B2JC36_NOSP7/14-67        AC B2JC36.1
#=GS A0A172Q635_9STRE/1-58     AC A0A172Q635.1
#=GS A0A673YB41_SALTR/225-302  AC A0A673YB41.1
#=GS LAFA_LACJO/1-75           AC P24022.2
#=GS D9SR36_CLOC7/1-58         AC D9SR36.1
#=GS A0A1I1FLD5_9LACO/3-79     AC A0A1I1FLD5.1
#=GS A0A4Y9FJR2_9STRE/8-71     AC A0A4Y9FJR2.1
#=GS A0A4Y9HC61_9BACL/5-68     AC A0A4Y9HC61.1
#=GS Q9A139_STRP1/2-63         AC Q9A139.1
#=GS Q8DVP7_STRMU/6-73         AC Q8DVP7.1
#=GS LAFX_LACJO/1-57           AC Q48509.1
#=GS A0A3N2KW95_9BACT/5-68     AC A0A3N2KW95.1
#=GS J1NZV6_STREE/1-61         AC J1NZV6.1
#=GS G5JPG8_STRCG/6-51         AC G5JPG8.1
#=GS Q9PCT5_XYLFA/1-72         AC Q9PCT5.1
Q8DWB6_STRMU/1-76                    ................................mewrintMEln......vnNYKSLTNDELSEVFGG..........---DKQAADTFLSAVGGAA.S.GFTyca...............sngVWHP..YILAGCAGVGAVGSVVF..............
A0A139WTX4_9CYAN/1-70                ..........................maiikitelqsvn--..........QVEELSNEDLTSVVGG..........-----LVGGLLGPTEPGAA.G.GGPf...................dIIPI..VGPLLSGLLGGFLGG--pa............
D9SPP3_CLOC7/1-70                    .......................................MT..........NFETCTMDELVLIDGGdw.....swkSLAQSTVSGAVGGAIAGSA.G.GTV.....................TLPV..VGTVGGGVGGGILGAV-ggaa..........
A0A1I1FJW3_9LACO/1-57                ....................................mnl--..........EIKVLNNNQLSKITGGk........kINWGSVGGSCIKGALFGAA.F.GGN.....................----..---AIGGCAGS------aaada.........
B9DTX8_STRU0/1-88                    ....................mekllfqkrkvdilmnsni--..........EFDSIDTELLEKVIGG.........kNNWQANVSGILAAGAAGAA.I.GAPvcglac.........gyigakTAIT..LWAGVTGATGGF-----k.............
A0A5C5TCW4_9STRE/1-50                ....................................melMN..........KFEEMTTEELATVDGG..........---MGVLAVIGYSVLAGTG.V.GIV.....................GYG-..-----------------varifg........
A0A085HK04_9GAMM/1-59                .......................................--..........-MRELNKNEMEAVNGG..........-----CIEGALDGAACASA.I.GQSkgwd............gfssfVFSA..FGAAVGAVVG-------sda...........
Q5FI73_LACAC/1-64                    .......................................ME..........KLMVLNEEKLSYVIGGgnp....kvaHCASQIGRSTAWGAVSGAA.T.GTA.....................----..VGQAVGALGGALFGGS-m.............
A0A2L0D506_9STRE/1-63                .....................................mg--..........---ELNFEQLSQIRGG..........---GKKAADIYVSAISGAA.Q.GAMlca..............qtgvVVQP..GVILGCAGAGAVLGVM-f.............
A0A139NEU2_9STRE/3-63                .......................................FE..........HFETLNENNLRDIYGG..........----NNAGAAVVAAMSCAA.G.GIKl..................ggKFGP..WGAAIGGVGGAAICGY-l.............
B7GL23_ANOFW/1-65                    .......................................MR..........MFQELNHVELQGIDGGs.......wkSHVVNLVGVVSGFGTTGAV.I.GGS.....................FGGP..LGAAAGGFVGAHYGAV-a.............
L0KCR9_HALHC/1-56                    ...............................mnelstvg--..........NFEELSEDEYLNVDGG..........---LVITGTAVAAGVGCLA.G.GVT.....................VGYA..IGTV-------------iesv..........
G5JMJ7_STRCG/7-60                    .......................................FE..........QFEAVDNETLAIVKGG..........--LSDCAQGTLATAALGAA.T.GGG.....................---P..WGAVGGGLVGV------aaf...........
Q8DSB5_STRMU/7-81                    .......................................LE..........QFDAMDVDMLAAVEGGn.......wgQCIVGTGSSALAGGLAGAG.T.GAAvsapa...........aegggLGPI..AGAAIGWDLGAISGAGL..............
A0A4U1B4N5_9GAMM/1-58                .......................................--..........-MRELNTNELNHVSGGtd......agDIAIATGGSWAA-TVAGFA.I.GGP.....................----..VGAVAGFALGTLI----svgy..........
I0XAR7_9SPIO/63-123                  .................................eqtkes-E..........NTEYLSEDALEEVAGGs........vTSWMHRNKDWVIAATALAT.I.GAC.....................----..-----------------ymfnkylekksaa.
Q8DWB7_STRMU/1-63                    ..................................mdtqaFE..........QFDVMDSQTLSTVEGG..........---------KVSGGEAVAA.I.GIC.....................----..--ATASAAIGGLAGAT-lvtpycvgtwgl..
A0A383U1V8_9FLAO/1-51                .......................................ME..........NIKTLSYQEMQEIEGG.........iAPFIIAGAYIAGSFVAGLT.V.GAV.....................SAHI..VYE--------------ls............
R2SSJ5_9ENTE/1-56                    .......................................MQ..........NVKELNIQKMQKITGG..........---NSCTNGTIGGAIAGAP.G.GPL.....................-SFL..AGAAGGAVAGG------cikf..........
T1ZF07_STRIT/6-72                    .......................................LE..........KFEVLNSEMLASVEGGkrp...ggapVTGMTQAHYTCLAATWGAT.F.GGM.....................LAPIslIGSVPG-----------vlaacsg.......
A0A172Q9E3_9STRE/1-41                .......................................MEla......vnKFVELTDEELMEIEGG..........-----GVGVAIALFMAGYT.I.G--.....................----..-----------------kdi...........
A0A1M5QU07_9FIRM/1-73                .................................mtlnin--..........TFNELTYNELMLINGGew.....nwyAFFDAVVGGAVSGAIAGSA.V.GTM.....................TIPL..IGEVPGVIGGAVIGAI-gga...........
A0A1K1P8M8_9GAMM/1-66                .......................................--..........-MRELTSPEIASVSGGrlk...vpgaCSRATLLSNTGVAALGGGI.T.GLI.....................TGGP..LVGLGGAIFGGSMGA--ls............
A0A172Q613_9STRE/6-66                .......................................FE..........QFATLTDAELSAVEGG..........------GCNWRDADKAGVA.G.GIG.....................----..-GLIGGGPVGGIAGIA-gglaaygatcw...
A0A380KA75_9STRE/5-72                .......................................MK..........QFEVMNEQQLVAVEGG..........---KVNWGRIGMCALSVAA.GaGQAymst.............aggtAFLG..PYAIGTGAIGAIIGGA-g.............
A0A437STT6_9LACO/1-62                .......................................--..........-MEILAKSTLREVIGGvs......rrNKVKHCGMDILKGAKTGAT.I.FAP.....................-LGV..GGVVGGANAGLIVGS--gf............
Q8DSA2_STRMU/6-59                    .......................................LE..........QFDVMDSQVPSAIEGG..........------GCSWKGADKAGFS.G.GVG.....................---G..LIGAGGNPVGGVLGIA-gg............
I5BT60_9BACT/1-79                    .................mkggrflkilnrvgvkqnlfim--..........QFEELNNNELAEVNGG..........-----LLGGLLGGVLGGNN.S.GQN.....................----..---ASGGLLGGFLGGL-lggnnsggfg....
A0A6A0BAV4_9LACT/2-53                ..................................nnvagLD..........NFSSLTKDEMMMVEGG.........aINVGNLVKAIGAVYAAGYA.V.GSF.....................----..-----------------vgnll.........
J0VAD1_STREE/6-84                    .......................................ME..........QFHEMDITMLSSIEGG.........kNNWQTNVLEGGGAAFGGWG.L.GTAicaasgvgapfmgacgyigakFGVD..LWAGVTGATGGF-----..............
B7GL22_ANOFW/1-86                    ...............................megvvftm-Elml...ekngSISFLSEEELKEIDGGrgs...wtnaVIGAGTLSPIVASAVRGAQ.Q.GVRf..................grLGGP..WGVVAGAVVGAVVGGYL..............
Q8DW08_STRMU/1-66                    ..................................mdtmaFE..........NFDEIDMNHLASIEGG..........-------FDVKGVAASYLA.M.GTA.....................--AL..GGLACTTPVGAV-----lylgaevcagaav.
Q1WQX8_LACS1/1-65                    .................................mknldk--..........RFTIMTEDNLASVNGGkngy..ggsgNRWVHCGAGIVGGALIGAI.G.GPW.....................----..-----SAVAGGISGGF-t.............
L0KBX3_HALHC/1-64                    ...............................mdnlasvg--..........-MVELNEEELMMVDGG..........---FFSVTDLGWAAAGGAI.S.GAI.....................TYGS..IGGAPGAVAGAFTGAAL..............
A0A346NQ03_9ALTE/1-86                ................mdiymfkekseqrgltnnrknsn--..........SFKILDDDEVAAVSGG..........--ISQSTQIASQMAFVGSG.I.GLY.....................AAGV..VLAPFGAA---------lfigtslaltgsyl
J0V0Y6_STREE/1-49                    ..................................mdtkmMS..........QFAVMDNEMLACVEGG..........DIDWGRKISCAAGVAYGAI.D.G--.....................----..-----------------cattv.........
Q5M2W2_STRT2/6-69                    ......................................i-E..........NFNTLDLETLASVEGG..........------GCSWGGFAKQGVA.T.GVGng.................lrLGIK..TRTWQGAVAGAAGGAIVggvg..........
A0A553GSH8_9BACT/1-54                ..............................mknlndlgv--..........--QELSKKDMKKTDGG..........-----GWRGAIAGACLGAM.T.GNP.....................----..AGVLIGAIAGAF-----i.............
A0A139NHC3_9STRE/1-58                .................................mttqiv-K..........KFETLDIETLSHVEGG..........VNWAACYAGTIGSALVGSA.G.GPV.....................----..-GYWGGALVG-------yat...........
A0A0Q0H9K4_9GAMM/1-66                ...............................mrlesken--..........KMRELTNNEIQEVNGG..........---PLPVIIAGLYASSSIT.A.GGL....................aTALG..IGAGFGAIVGGIAA---iyh...........
W7CPH2_9LIST/1-57                    ....................................mkk--..........--ELLNKNEMSRIIGG..........---KINWGNVGGSCVGGAV.I.GGA.....................LGGL..GGAGGGCITGAIG----siw...........
Q8DRN0_STRR6/6-65                    .......................................MS..........QFEIMDTEMLACVEGG..........------GCNWGDFAKAGVG.G.GAVrg.................lqLGIK..TRTWQGAATGAAGGAIL..............
A0A347WMH6_9LACT/1-58                ................................mntqtis--..........QFELLDTELLATVEGG..........-ASGKCIAGVVVGALLGSV.G.GPW.....................----..-GSAAGGAVGA------gff...........
A0A673YBB6_SALTR/227-304             eenlkkifegealekarmelrekherearekaermntaa--..........----------------..........----RYLGAAGSVAASGAT.I.GGV.....................IGGP..PGAVVGAVAGAIAGV--i.............
A0A673YBB4_SALTR/227-304             eenlkkifegealekarmelrekherearekaermntaa--..........----------------..........----RYLGAAGSVAASGAT.I.GGV.....................IGGP..PGAVVGAVAGAIAGV--i.............
D9SSI4_CLOC7/4-70                    ....................................lvn-E..........NFTDLRIDEIEFINGGm.......sdWDWVWCGVVTAGCTVIGAA.I.GTA.....................VCPG..IGTIGGANAGSVLGGIF..............
Q8DS95_STRMU/6-72                    .......................................FE..........QFNVMDNEALSAVEGG..........----GRGWNCAAGIALGAG.Q.GYMata...............ggtAFLG..PYAIGTGAFGAIAGGI-ggal..........
A0A4Y9F9Q7_9STRE/1-62                .......................................--..........----MTDVELVEVIGGg.......wvQCGLGTVGGALTGAVAGAA.V.GTV.....................TLPV..IGTVSGSAVGFWGGGS-agaa..........
A5CZV1_PELTS/2-61                    .......................................LE..........QSDELSEEELEQVAGG..........-------GVLALVALGLYA.A.GAT.....................---A..VGVGVGAVAGAALAG--avvgvtalvg....
Q8DSB1_STRMU/10-94                   ..........................mdemriymmeikaLD..........QFETMDTDMLAAVEGGfgwdsiwrgfKCVAGTAGTIGTGALGGSA.T.GGL.....................TLPI..IGHVSGGIIGGISGAGV..............
A0A437SU16_9LACO/11-85               ....................................ylk--..........----LKENELNKVLGGis......krNKVKRCAKEIFGSAATGAA.S.GAVrgtf.............vepgY---..-GTLGGALMGAAGGI--fsggamcvgd....
G5JMJ6_STRCG/6-59                    .......................................LE..........QFDVVDEKTLSEINGG..........----DGVAQCIIGTAGGAI.W.GNA.....................AFGL..IGAGVGTFIG-------ntv...........
A0A1H1YFL4_9BACL/1-82                ..............................mqatltnnl--..........-FHEMDVDQLLMVDGGdw.....sfkDFWKDTAKGAVGGAISGGV.G.GAV.....................ATGG..PGVIPGAVAGGIVGAA-ggavgylvag....
A0A139NEK0_9STRE/1-72                ..................................manvd-K..........QFQVLTAEELMEIHGGn.......nyGHYNPSAQDILKAAASGAIqV.GATc...................lPAGA..WAVAGCALVGGLWGGY-i.............
A0A1I7JF40_9FIRM/1-74                .......................................MEn........tMFYEIENEQLFNVEGG..........-NVVGDAATILGAGAAGAE.I.GGA.....................IGGA..IGGPGGAFTGGVVGG--aigvgcgvmivvt.
Q1WQX7_LACS1/2-62                    .......................................MK..........EFTVLTECELAKVDGG..........KRGPNCVGNFLGGLFAGAA.A.GVP.....................-LGP..AGIVGGANLGMVGGA--lt............
A0A1A9HNN2_9BURK/1-62                ......................................m-E..........-LRELTLEEIEIVAGG..........-ISDALLSDIGKGALAGGF.A.GFAv...................tGGTP..VGFLGGAAVGAVGGAV-h.............
J1P4N6_STREE/6-65                    .......................................MS..........QFEIMDTEMLACVEGG..........------GCNWGDFAKAGVG.G.GAArg.................lqLGIK..TRTWQGAATGAVGGAIL..............
A0A380KA66_9STRE/2-55                ...................................mtav-E..........QFEALNEDKLELIEGGd.......waKCVLGTTSIARLRYLSGGV.V.GGW.....................----..-----------------sgvlegv.......
A0A4Y9HE79_9BACL/3-53                ...................................vllv--..........--KELTFEELLVVDGG..........TNWAGLASCTLGATVGGAV.G.GLV.....................--GV..AG---------------ygatcw........
A0A380KBI2_9STRE/1-76                ..................................mntvl-N..........QFEVMDDIKLSSVTGG.........gCNWAGAAATVGVGVVGGAI.K.GFVkshtw...........qgavlKGIG..YGIKSGVAY--------gatckwt.......
A0A145WNP8_9GAMM/30-71               ..................................skksr--..........----------------..........------FSPTVKGALIGAA.A.GSV.....................-LPV..FGTISGAVIGAVSG---kiy...........
Q8DSA3_STRMU/1-62                    .......................................MEkq......ynNFKILNTDALENIQGGgr.....aprCAALVGASIYDGLAVVGDP.V.GVA.....................----..-MAAGTIAAGSF-----c.............
T1ZF04_STRIT/6-65                    .......................................LE..........KFEALNSEMLARVEGG..........------GCNWGDFAKSGIA.G.GAGng.................lrLGIK..TRTWQGVVAGAIIGGV-g.............
M9L947_PAEPP/1-82                    .......................................MS..........RFVELNRNELEQVDGGgfsw..eglgKCVAGTAGGVVAGGTSGFL.A.GVSagrag..........gpqataAGGT..IGGVGGAIGGGLTG---aaas..........
A0A172Q637_9STRE/6-62                .......................................LE..........QFVTLTDTELSAVEGG..........KNKDGRDLACVLGTAGMAG.A.GFL.....................FAGP..GGA---AVLGG------atal..........
T1ZF76_STRIT/6-75                    .......................................LE..........KYEVLNSEMLASVEGG..........YNTSDCLKDYGKGFLSGTA.A.GAA.....................-WGS..IAGGIGALPGAFVGAHVgiiggglac.....
A0A1E5G4L8_9BACL/1-55                .......................................MS..........NLQALSHEELIGIEGG..........-----YGTDLLKGAARGAA.L.GFV.....................----..----AGGFAGAFVGAHVgvglag........
A0A1G6X8W7_9GAMM/1-57                .......................................--..........-MQTLSNIQLEQVGGG..........--NECHVNTVAGAAMVGAG.V.GFL.....................----..LGGPIGAAAGAISAG--ghalig........
F9HJ90_9STRE/1-56                    ...............................mkplnkmd-E..........QFYVLSDEEMATVEGG..........------GILFGIVIVGGII.V.GGT.....................----..------FVLGAIDGA--mgara.........
A0A673YB45_SALTR/225-302             eenlkkifegealekarmelrekherearekaermntaa--..........----------------..........----RYLGAAGSVAASGAT.I.GGV.....................IGGP..PGAVVGAVAGAIAGV--i.............
W7CGP1_9LIST/1-68                    .......................................MH..........KVKKLNNQELQQIVGGys......skDCLKDIGKGIGAGTVAGAA.G.GGL.....................-AAG..LGAIPGAFVGAHF----gviggsa.......
A0A4Q1SLZ3_9BACL/1-64                .......................................ME..........KLMVLNEEKLSYVIGGgnp....kvaHCASQIGRSTAWGAVSGAA.T.GTA.....................----..VGQAVGALGGALFGGS-m.............
A0A1M5QU89_9FIRM/1-76                ......................................m-Emtl....ninSFNELTNDELMLVNGG..........---EWSWGAFFGSVFKGME.K.GYHdadpna.........ttkvpyIGEV..PAPIVGALVGGIHGA--i.............
A5M6F3_STREE/1-75                    ..................................mdtkmMS..........QFSVMDTEMLACVEGGg........cNWGDFAKAGVGGAAARGLQ.L.GIK.....................----..TGTWQGAATGAAGGAILggvayaatcw....
A0A2L0D508_9STRE/1-69                .......................................ME..........QFEVMDEMALSNIEGG..........----NDVLITAGSAIAGGI.V.GYLac................sasIVAA..PVAGACAYTGAKIGGA-gyliarh.......
I5BT61_9BACT/1-71                    .................mkgrrflkilnrvgvkqnlfim--..........QFEELNNNELAEVNGG..........-----ILGGLLGGLLGGNN.F.GQS.....................----..--ASSGALLGG------lnltil........
F5IUS8_9BACT/1-57                    ......................................m-EkelttlnetsEFKELTKEEMAAINGGya......igDYLKDLYESAGAAVAAGAA.A.GAA.....................----..-----------------ai............
D9SR35_CLOC7/1-57                    .......................................ME..........NFVSLTEVELHEIEGGrw......swKKIAKVAFAVIKTATTIAS.G.GAV.....................---I..PAVI-------------kgaitii.......
A0A4Q7PJR5_9FLAO/1-62                .......................................--..........-MKTLEINKMESIQGG..........DCVEETVSAGVKGAVGGAI.T.GALa..................ggVGAL..PGAAGGWLVGALSG---lva...........
A0A371QME9_9BACT/4-68                ........................aiklpnnikannpnn--..........NLSLLDDNELKSINGG..........AKPVAPLFGWKAAALLVGG.T.GAA.....................--II..VGVAGT-----------yll...........
G6ERX6_STRTR/6-68                    ......................................i-E..........NFNTLDLETLASVEGG.........gCSWGGTGGATVQGAIGGAF.G.GNV.....................VLPV..VGSVPGYLAGGVLGGA-g.............
A0A1X1Q5U5_9FIRM/68-131              ............................lkeyeqeqmkn--..........--MTLSEDELEQVAGG..........----TNGGGINACAFLGIG.L.GKT.....................-SKK..NRTAVCFIIGGS-----ngpva.........
A5M6F0_STREE/6-63                    .......................................ME..........QFSVMDNEELEIVSGGrg.....nlgSAIGGCIGAVLLAAATGPI.T.GGA....................aTLIC..VGSG-------------its...........
B2JC36_NOSP7/14-67                   ..................................ekevl--..........-LSELSDEEMATIQGG..........--SNAPAEVLAVCAVGGAV.L.GGP.....................----..----AGFLGGAFVGAIL..............
A0A172Q635_9STRE/1-58                .......................................ME..........QFQLIEDNELEMIVGG..........KVSPTCAALVAASIYGGLA.I.---.....................-AGP..VGVGVAMATGGVAAGSF..............
A0A673YB41_SALTR/225-302             eenlkkifegealekarmelrekherearekaermntaa--..........----------------..........----RYLGAAGSVAASGAT.I.GGV.....................IGGP..PGAVVGAVAGAIAGV--i.............
LAFA_LACJO/1-75                      .......................................MK..........QFNYLSHKDLAVVVGG.........rNNWQTNVGGAVGSAMIGAT.V.GGTicgpac.........avagahYLPI..LWTAVTAATGGFGKI--rk............
D9SR36_CLOC7/1-58                    .......................................ME..........NFKTLSEVELHQIDGGkw......kwKKIIKIAAAVAGTVVTIAS.G.GAA.....................----..---APAVIGGA------iavan.........
A0A1I1FLD5_9LACO/3-79                ....................................qlt--..........--NTLTSQELAEISGGys......rgQCYKAMASGAAWGALRGGM.S.GTF.....................AGGP..VGTIGGAIAGAHLGAI-ggtaacvggylfg.
A0A4Y9FJR2_9STRE/8-71                ...................................ltyy--..........--EKLDTKNLVEVRGG..........---GAREGDMFLSAAAGAA.N.GIAmca..............qfglYIPW..QGYAVCAVGGAAS----nl............
A0A4Y9HC61_9BACL/5-68                .....................................lv--..........--KELTFEELLVVDGG..........TNWAGLASCTLGATVGGAA.A.GFA.....................----..-FAGVGAGAGALLG---fnyglgacmlag..
Q9A139_STRP1/2-63                    ....................................ikf--..........-AEEIQKEELFHIIGG..........YSATDCKNHLIGGITSGAI.A.GGV.....................GAGM..ATLGVGGVAGAFAGAHV..............
Q8DVP7_STRMU/6-73                    .......................................FE..........QFNVMDNEALSTVEGGg.......miRCALGTAGSAGLGFVGGMG.A.GTV.....................TLPV..VGTVSGAALGGWSGAAVgaa...........
LAFX_LACJO/1-57                      .....................................mk--..........----LNDKELSKIVGG..........----NRWGDTVLSAASGAG.T.GIKa..................ckSFGP..WGMAICGVGGAAIGGYF..............
A0A3N2KW95_9BACT/5-68                ...................velqnqpvsrgigdsilsav--..........----------------..........KCIAGTAGSAGLGFLAGAG.V.GTV.....................TLPV..VGTVSGGAVGGWSGAL-v.............
J1NZV6_STREE/1-61                    .................................mntycn--..........----INETMLSEVYGG..........----NSGGAAVVAALGCAA.G.GVKy..................grLLGP..WGAAIGGIGGAVVCGYL..............
G5JPG8_STRCG/6-51                    .......................................LE..........QFDVMDEQALAAVEGG..........-------GYWDDYPLVGAA.A.GVLf...................gT---..-----------------ggyllqnya.....
Q9PCT5_XYLFA/1-72                    ...................mdiailvyrdvylnsfkesl--..........KMRELTFEEALKVDGQ..........--------GWAGAFLTGAG.T.GAY.....................AGGL..IAEVPGAVVGAVVGGV-i.............
#=GC seq_cons                        ...................................................php.LspppLtpVpGG..............thssshssuuhuGus.s.Gss......................h....husssGuhsGuh.s...h.............
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