#=GF ID Beta-prism_lec
#=GF AC PF16458.8
#=GF DE Beta-prism lectin
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE PDB:4gx7
#=GF GA 25.00 25.00;
#=GF TC 25.20 36.60;
#=GF NC 23.20 21.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0568
#=GF RN [1]
#=GF RM 15978620
#=GF RT Crystal structure of the Vibrio cholerae cytolysin (VCC)
#=GF RT pro-toxin and its assembly into a heptameric transmembrane pore.
#=GF RA Olson R, Gouaux E;
#=GF RL J Mol Biol. 2005;350:997-1016.
#=GF RN [2]
#=GF RM 21502531
#=GF RT Crystal structure of the Vibrio cholerae cytolysin heptamer
#=GF RT reveals common features among disparate pore-forming toxins.
#=GF RA De S, Olson R;
#=GF RL Proc Natl Acad Sci U S A. 2011;108:7385-7390.
#=GF RN [3]
#=GF RM 23274141
#=GF RT Vibrio cholerae cytolysin recognizes the heptasaccharide core of
#=GF RT complex N-glycans with nanomolar affinity.
#=GF RA Levan S, De S, Olson R;
#=GF RL J Mol Biol. 2013;425:944-957.
#=GF DR INTERPRO; IPR032496;
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC This beta-prism fold lectin is the C-terminal domain of the
#=GF CC Vibrio cholerae cytolytic pore-forming toxin hemolysin [1-2]. It
#=GF CC binds to N-glycans with a heptasaccharide GlcNAc4Man3 core
#=GF CC (NGA2) [3].
#=GF SQ 14
#=GS Q9KTH2_VIBCH/822-956 AC Q9KTH2.1
#=GS Q9KTH2_VIBCH/822-956 DR PDB; 5V6F A; 823-956;
#=GS Q9KTH2_VIBCH/822-956 DR PDB; 5V6C A; 823-956;
#=GS Q9KTH2_VIBCH/822-956 DR PDB; 5V6K A; 823-956;
#=GS Q9KTH2_VIBCH/822-956 DR PDB; 5V6C C; 823-956;
#=GS Q9KTH2_VIBCH/822-956 DR PDB; 5V6C B; 823-956;
#=GS HLYA_VIBCH/611-739 AC P09545.2
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 I; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 H; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 N; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 E; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 4GX7 D; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 D; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 4GX7 E; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 G; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 4GX7 A; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 J; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 B; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 4GX7 F; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 4GX7 C; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 1XEZ A; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 M; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 A; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 L; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 4GX7 B; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 F; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 K; 586-714;
#=GS HLYA_VIBCH/611-739 DR PDB; 3O44 C; 586-714;
#=GS A0A1E5CMQ6_9VIBR/629-758 AC A0A1E5CMQ6.1
#=GS A0A233HNU4_9VIBR/610-738 AC A0A233HNU4.1
#=GS A0A2V1HA38_9GAMM/765-897 AC A0A2V1HA38.1
#=GS Q9KQW0_VIBCH/317-452 AC Q9KQW0.1
#=GS Q9KQW0_VIBCH/317-452 DR PDB; 6MLT A; 317-414;
#=GS A0A1E5CMQ6_9VIBR/312-445 AC A0A1E5CMQ6.1
#=GS A0A233HBX0_9VIBR/822-956 AC A0A233HBX0.1
#=GS A0A0M0I2N6_9VIBR/407-536 AC A0A0M0I2N6.1
#=GS A0A233HBX0_9VIBR/507-637 AC A0A233HBX0.1
#=GS A0A233HFC1_9VIBR/317-453 AC A0A233HFC1.1
#=GS A0A0M0I2N6_9VIBR/718-845 AC A0A0M0I2N6.1
#=GS Q9KTH2_VIBCH/507-637 AC Q9KTH2.1
#=GS A0A0Q2MKS2_VIBFU/587-715 AC A0A0Q2MKS2.1
Q9KTH2_VIBCH/822-956 e-SPIFGY-SNTQ..QSQRVVTA..DNLMYLRSGFAIDAIGTTVNNLVGGpvqgtNGGVLRAPIALDQLQSVEVTSGLYN..WG.GYHIVA.IKFTMKDGSSVLLGSTH..Y.ASNKKVETY.TVP...QGKRIKQINVWTGGWLVEGFQF-v.....................................
#=GR Q9KTH2_VIBCH/822-956 SS X----EE---SSE..EEEEE--T..T-EEEEEESSSEEEEESSSS--EES-BCTTBS-EE---EEGGGEEEEEEEEEEET..TS.SEEEEE.EEEEETTS-EEEEE-SS..S.EEEEEEEEE.E--...TT----EEEEEESSSSEEEEEE-E.....................................
HLYA_VIBCH/611-739 .SSPILGY-TQGK..MNQQRVGQ..DHRLYVRAGAAIDALGSASDLLVGG.....NGGSLSS-VDLSGVKSITATSGDFQ..YG.GQQLVA.LTFTYQDGRQQTVGSKA..Y.VTNAHEDRF.DLP...AAAKITQLKIWSDDWLVKGVQFD......................................
#=GR HLYA_VIBCH/611-739 SS .B--EEE----SE..EEEEE--T..T-EEEEEESSSEEEEESSTTSEEE-.....S-SEEEE-EE-TTEEEEEEEEEEES..SS.SEEEEE.EEEEETTS-EEEEE-SS..S.EEEEEEEEE.E--...TT--EEEEEEEE-SSSEEEEEEE......................................
A0A1E5CMQ6_9VIBR/629-758 k-SPIFGRQT-GE..ISNHHVLN..DQTLFVRSGFAIDALGTSLDHLAGG.....DGGALRSPVNLAQVESIQVTSGDYY..WG.GNHIIA.LKFTFKNGSSILMGSKH..Y.ASNKVVETF.TIP...QGTQIQQMNVWTNGWLVDGLQFE......................................
A0A233HNU4_9VIBR/610-738 e-SAVFGF-TSGS..LALQDVGQ..SGTLYIRHGAAIDAIGTQANAMQGG.....ESGSLTE-IDLKRVTQITVTSGEFK..YG.GNHLLR.MTFKLDDGSTKVVGSKD..Y.AISTHDEVF.ELP...AGSAIRQVKVWSEGWLADGIQF-i.....................................
A0A2V1HA38_9GAMM/765-897 r-SPVFGESQPGD..STNNYIVQppSYSIAMRCGWIVDAMGTT-ESLTGG.....PGGALLSINNVQDVVRIDVTTAIFSgvNG.QEKTIAkLVYTFKDNSTQFCGTNQ..G.TTSASTSTY.TVP...TGYVLQGY---------------evsggryihavrf.........................
Q9KQW0_VIBCH/317-452 q-SAVYGY-TDWA..HQQRVLAE..NHQLAIRSGAVVDAIGANSQNMIGG.....SGGSLST-IDTSKVRAIDVTYGKNK..YTwKYGVLE.MSFTLDNGAKVTVGSKD..S.AFT------.---...-----------------------ylglewktktvpylgvewrtktvsywffgwhtkqvayl
#=GR Q9KQW0_VIBCH/317-452 SS E----EE---TT-..--EEEE-B..TTEEEEEESSSEEEEESSTTSEEE-.....S-SEEEE-EEGGGEEEEEEEEEEET..TT--EEEEE.EEEEETTS-EEEEE-GG..G.EEE------.---...-----------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
A0A1E5CMQ6_9VIBR/312-445 l-SKIFGYANYHSspSATITIEE..SDKLWIRSGAAIDAIGTAPNSVVGG.....NGGYLNSPIDLSQVEAIDITSGRYW..WG.RYHVLA.LDFYLKDGSQVSMGSKR..YySHHIKTERV.TVP...HNSFIKSINVWTSYWLVDGLQFQ......................................
A0A233HBX0_9VIBR/822-956 e-SPIFGY-SNTQ..QSQRVVTA..DNQMYLRSGFAIDAIGTTANNLVGGpvqgtNGGVLRAPIALEQLQSVEVTSGLYN..WG.GYHIVA.IKFTMKDGSSVLLGSTY..Y.ASNKKVETY.TVP...QGKRIKQINVWTGGWLVEGLQF-v.....................................
A0A0M0I2N6_9VIBR/407-536 k-SKLFGY-EYGE..DENLTVED..NNLLYVNSGLAIDAVGTTSQNLFGG.....EGGHTNAPVDLTKVEKIAITSGAYY..WG.GKHLLA.MKFFMKDGSSVMFGSKN..S.SYWQSTDYF.VVP...EGKKISAVNVWSNGWLVEAIQFE......................................
A0A233HBX0_9VIBR/507-637 .FSKIYGYQPNSN..PASIVLAV..DGKISVRSGFAIDAIGASASTLVGG.....TGGNLNAAVNVEDIKAIDLTWGKYY..WG.GYHLLA.LDFRMSNGSVISMGSKN..Y.AYSKQTERF.TVP...AGSRIKGIKAWSAGWLLDGVQFE......................................
A0A233HFC1_9VIBR/317-453 k-SPVYGYTHLHH..SHPVKIAD..DNQLKIRSGDLIDAIGSTASNMVGG.....QGGSLHT-IDASKVRSVDVTYGKYK.tWW.TYGVLE.MEFTLNDGSKITLGSKDsaF.KYPALEWRTkEVPylgLEWRTKQVSYWSFGWHTKTVS--yl....................................
A0A0M0I2N6_9VIBR/718-845 s-SGIFGF-PSG-..-NSVKVEL..DDDLFIRSGWIIDAMGADYHNMVGG.....NGGGLRTPVDLDQVASIEVTSGTYY..WG.SNHIVK.LKFTYHNGTVLSYGYKK..Y.SYNLKTETV.TLS...EDDEIAAISVWSSGAYVDAIQF-h.....................................
Q9KTH2_VIBCH/507-637 .FSKVYGYQPNNN..PASIALAV..DGKISVRSGFAIDAIGASASTLVGG.....TGGNLNAAVNVKDIKAIDLTWGKYY..WG.GYHLLA.LDFRMSNGSVISMGSKN..Y.AYSKQTERF.TVP...AGSRIKGIKAWTAGWLLDGVQFE......................................
A0A0Q2MKS2_VIBFU/587-715 t-SPVLGL-AVGQ..LNAQPLSA..EGILFVRSGAAIDALGTAEGLMVGG.....SGGSLSQ-VDLRQVQSVVATSGDFN..YG.GQQLLA.LTLTYLGGRVQTLGSKQ..Y.GTHLHEDRF.DVP...AGQSITAVKIWADNWLVKGLQLE......................................
#=GC SS_cons EB--EEE---TSE..EEEEEE-T..TTEEEEEESSSEEEEESSTTSEEES.BCTTSSSEEEE-EEGGGEEEEEEEEEEET..TS-SEEEEE.EEEEETTS-EEEEE-SS..S.EEEEEEEEE.E--...TT--EEEEEEEESSSSEEEEEEEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons p.SslaGY.sssp...sshslst..-spLalRSGhAIDAlGosssslVGG.....sGGsLpu.lsLppVpuI-lTSGcYh..WG.G.HllA.lcFThcsGSslshGSKp..Y.uhstps-pa.sVP...tGppIptlplWosGWLl-GlQF.......................................
//
