GenomeNet

Database: Pfam
Entry: C4bp_oligo
LinkDB: C4bp_oligo
Original site: C4bp_oligo 
#=GF ID   C4bp_oligo
#=GF AC   PF18453.4
#=GF DE   Oligomerization domain of C4b-binding protein alpha
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF01966
#=GF GA   29.60 29.60;
#=GF TC   32.00 32.00;
#=GF NC   28.80 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   23274142
#=GF RT   Arranged sevenfold: structural insights into the C-terminal
#=GF RT   oligomerization domain of human C4b-binding protein.
#=GF RA   Hofmeyer T, Schmelz S, Degiacomi MT, Dal Peraro M, Daneschdar M,
#=GF RA   Scrima A, van den Heuvel J, Heinz DW, Kolmar H;
#=GF RL   J Mol Biol. 2013;425:1302-1317.
#=GF DR   INTERPRO; IPR040514;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the C-terminal oligomerization domain found in
#=GF CC   C4b-binding protein (C4BP), which contains 14 cysteines that
#=GF CC   form 7 intermolecular disulfide bridges. C4BP is a plasma
#=GF CC   glycoprotein complex of 570 kDa, which is mainly produced in the
#=GF CC   liver. C4BP is the major inhibitor of complement activation, the
#=GF CC   major isoform consists of 7alpha and one beta-chain where each
#=GF CC   alpha-chain comprises eight complement control domain proteins
#=GF CC   (CCPs) and a C-terminal oligomerization domain. This domain
#=GF CC   carries a stretch of 42-45 amino acids that has been shown to be
#=GF CC   required for ring formation [1].
#=GF SQ   243
#=GS G1L9X2_AILME/550-597      AC G1L9X2.2
#=GS A0A4W2CZQ0_BOBOX/550-598  AC A0A4W2CZQ0.1
#=GS A0A452C9N0_BALAS/578-626  AC A0A452C9N0.1
#=GS A0A2U3XG79_LEPWE/542-590  AC A0A2U3XG79.1
#=GS ZP3R_CAVPO/468-515        AC O08569.1
#=GS E9PZ07_MOUSE/468-515      AC E9PZ07.1
#=GS A0A2Y9Q1I2_DELLE/49-89    AC A0A2Y9Q1I2.1
#=GS A0A383Z974_BALAS/609-657  AC A0A383Z974.1
#=GS A0A2K5UC71_MACFA/542-590  AC A0A2K5UC71.2
#=GS A0A673TR05_SURSU/147-194  AC A0A673TR05.1
#=GS A0A7E6CWT8_9CHIR/145-188  AC A0A7E6CWT8.1
#=GS A0A6I8P2W5_ORNAN/492-539  AC A0A6I8P2W5.1
#=GS A0A5F9CJA1_RABIT/541-589  AC A0A5F9CJA1.1
#=GS A0A643BQK8_BALPH/161-205  AC A0A643BQK8.1
#=GS A0A5N4CI57_CAMDR/474-522  AC A0A5N4CI57.1
#=GS A0A6P6DA41_OCTDE/495-542  AC A0A6P6DA41.1
#=GS H2N3W0_PONAB/558-606      AC H2N3W0.2
#=GS A0A2K6LS37_RHIBE/526-574  AC A0A2K6LS37.1
#=GS A0A2K5CS31_AOTNA/544-592  AC A0A2K5CS31.1
#=GS A0A2R9BXJ3_PANPA/541-589  AC A0A2R9BXJ3.1
#=GS A0A3Q7MV65_CALUR/565-612  AC A0A3Q7MV65.1
#=GS C4BPA_MOUSE/416-464       AC P08607.3
#=GS A0A3P4N1A1_GULGU/120-167  AC A0A3P4N1A1.1
#=GS A0A2K5ZIZ4_MANLE/516-564  AC A0A2K5ZIZ4.1
#=GS A0A2K6CCW8_MACNE/542-590  AC A0A2K6CCW8.1
#=GS A0A6J0Z918_ODOVR/699-747  AC A0A6J0Z918.1
#=GS A0A452E9D0_CAPHI/496-548  AC A0A452E9D0.1
#=GS A0A6I9IZX7_CHRAS/145-187  AC A0A6I9IZX7.1
#=GS W5PDE5_SHEEP/146-193      AC W5PDE5.1
#=GS A0A673TQG4_SURSU/145-189  AC A0A673TQG4.1
#=GS A0A287A7D4_PIG/488-536    AC A0A287A7D4.1
#=GS A0A383Z8U7_BALAS/577-625  AC A0A383Z8U7.1
#=GS A0A340YCM8_LIPVE/609-657  AC A0A340YCM8.1
#=GS A0A383Z9M6_BALAS/559-607  AC A0A383Z9M6.1
#=GS G3V902_RAT/510-558        AC G3V902.1
#=GS Q1RMN9_BOVIN/145-193      AC Q1RMN9.1
#=GS A0A671FUB3_RHIFE/145-188  AC A0A671FUB3.1
#=GS A0A6P3IKM6_BISBI/145-193  AC A0A6P3IKM6.1
#=GS A0A2U3X0R2_ODORO/153-197  AC A0A2U3X0R2.1
#=GS A0A6J3R270_TURTR/537-585  AC A0A6J3R270.1
#=GS A0A452RCD0_URSAM/152-196  AC A0A452RCD0.1
#=GS E9PVX4_MOUSE/447-494      AC E9PVX4.1
#=GS A0A2I2YKD7_GORGO/510-558  AC A0A2I2YKD7.1
#=GS C4BPA_RAT/504-552         AC Q63514.1
#=GS G3X2N5_SARHA/520-568      AC G3X2N5.1
#=GS G1TPZ5_RABIT/492-540      AC G1TPZ5.2
#=GS A0A671FUS6_RHIFE/145-192  AC A0A671FUS6.1
#=GS A0A5F5Y0X6_FELCA/146-194  AC A0A5F5Y0X6.1
#=GS A0A6I9J0S4_CHRAS/541-589  AC A0A6I9J0S4.1
#=GS A0A7E6CXM8_9CHIR/551-599  AC A0A7E6CXM8.1
#=GS A0A3Q1NK73_BOVIN/143-187  AC A0A3Q1NK73.1
#=GS F6SZ76_ORNAN/545-592      AC F6SZ76.2
#=GS A0A1S3F805_DIPOR/510-558  AC A0A1S3F805.1
#=GS L9JB00_TUPCH/145-190      AC L9JB00.1
#=GS A0A2K5Q4R0_CEBIM/489-536  AC A0A2K5Q4R0.1
#=GS A0A2K6GP77_PROCO/540-588  AC A0A2K6GP77.1
#=GS M3WJK3_FELCA/544-591      AC M3WJK3.4
#=GS A0A4V5P9J4_MONMO/427-475  AC A0A4V5P9J4.1
#=GS A0A2K6U658_SAIBB/545-593  AC A0A2K6U658.1
#=GS A0A4W2E482_BOBOX/139-190  AC A0A4W2E482.1
#=GS A0A4W2CIV1_BOBOX/550-598  AC A0A4W2CIV1.1
#=GS A0A2Y9PVL3_DELLE/559-607  AC A0A2Y9PVL3.1
#=GS A0A3Q1LUK9_BOVIN/501-549  AC A0A3Q1LUK9.1
#=GS A0A452C960_BALAS/591-639  AC A0A452C960.1
#=GS A0A6J0CSM0_PERMB/509-555  AC A0A6J0CSM0.1
#=GS F7DFU6_MONDO/521-569      AC F7DFU6.3
#=GS A0A6P3IN82_BISBI/142-193  AC A0A6P3IN82.1
#=GS F1PGM9_CANLF/550-598      AC F1PGM9.3
#=GS A0A1U7TXN9_CARSF/545-593  AC A0A1U7TXN9.2
#=GS A0A673TQX9_SURSU/147-194  AC A0A673TQX9.1
#=GS M3YEL9_MUSPF/550-597      AC M3YEL9.1
#=GS A0A485N1Z9_LYNPA/543-591  AC A0A485N1Z9.1
#=GS S7NS32_MYOBR/164-207      AC S7NS32.1
#=GS A0A6P3RME7_PTEVA/57-100   AC A0A6P3RME7.1
#=GS A0A2Y9JUL8_ENHLU/549-596  AC A0A2Y9JUL8.1
#=GS A0A452RCA9_URSAM/153-201  AC A0A452RCA9.1
#=GS A0A2K5PFU7_CEBIM/544-592  AC A0A2K5PFU7.1
#=GS A0A1S3F810_DIPOR/146-194  AC A0A1S3F810.1
#=GS A0A341BY82_NEOAA/145-189  AC A0A341BY82.1
#=GS A0A2I3SBS7_PANTR/508-556  AC A0A2I3SBS7.1
#=GS H0WP65_OTOGA/539-587      AC H0WP65.1
#=GS A0A5E4AHA1_MARMO/484-532  AC A0A5E4AHA1.1
#=GS L8ITE6_9CETA/113-163      AC L8ITE6.1
#=GS G3X970_MOUSE/512-559      AC G3X970.1
#=GS A0A340YJR7_LIPVE/145-189  AC A0A340YJR7.1
#=GS A0A212CRI8_CEREH/7-55     AC A0A212CRI8.1
#=GS I3M890_ICTTR/484-532      AC I3M890.2
#=GS A0A6J0A2G5_ACIJB/544-591  AC A0A6J0A2G5.1
#=GS A0A341BX82_NEOAA/559-607  AC A0A341BX82.1
#=GS A0A2K6S5N6_SAIBB/512-560  AC A0A2K6S5N6.1
#=GS A0A2U3X0P5_ODORO/543-590  AC A0A2U3X0P5.1
#=GS A0A5F9CCJ6_RABIT/541-589  AC A0A5F9CCJ6.1
#=GS C4BPA_BOVIN/544-592       AC Q28065.1
#=GS G3T0X1_LOXAF/505-553      AC G3T0X1.1
#=GS W5PBY0_SHEEP/559-607      AC W5PBY0.1
#=GS A0A4X2KW17_VOMUR/520-568  AC A0A4X2KW17.1
#=GS G1QJR5_NOMLE/398-446      AC G1QJR5.1
#=GS A0A2K5L395_CERAT/541-589  AC A0A2K5L395.1
#=GS G5BP10_HETGA/418-464      AC G5BP10.1
#=GS ZP3R_MOUSE/512-559        AC Q60736.1
#=GS A0A5F9D993_RABIT/541-589  AC A0A5F9D993.1
#=GS A0A6J3IS89_SAPAP/544-592  AC A0A6J3IS89.1
#=GS A0A2Y9FW89_TRIMA/145-192  AC A0A2Y9FW89.1
#=GS A0A6G1AJG4_CROCR/183-222  AC A0A6G1AJG4.1
#=GS C4BPA_HUMAN/541-589       AC P04003.2
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F E; 541-589;
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F F; 543-589;
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F B; 543-589;
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F A; 541-589;
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F C; 543-589;
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F G; 541-589;
#=GS C4BPA_HUMAN/541-589       DR PDB; 4B0F D; 543-589;
#=GS A0A6J0Z7P6_ODOVR/146-193  AC A0A6J0Z7P6.1
#=GS A0A452C9P0_BALAS/489-537  AC A0A452C9P0.1
#=GS L5MFL6_MYODS/522-569      AC L5MFL6.1
#=GS S7QEE1_MYOBR/503-550      AC S7QEE1.1
#=GS A0A3Q2HVB6_HORSE/658-706  AC A0A3Q2HVB6.1
#=GS M3YEL4_MUSPF/151-197      AC M3YEL4.1
#=GS A0A2K5I3J9_COLAP/512-560  AC A0A2K5I3J9.1
#=GS A0A7E6CWF9_9CHIR/125-168  AC A0A7E6CWF9.1
#=GS A0A2Y9PUN5_DELLE/560-608  AC A0A2Y9PUN5.1
#=GS A0A5F4BNP2_CANLF/475-523  AC A0A5F4BNP2.1
#=GS ZP3R_RAT/510-558          AC Q7TSY4.1
#=GS A0A3Q7VF55_URSAR/152-196  AC A0A3Q7VF55.1
#=GS A0A2K5CER2_AOTNA/467-516  AC A0A2K5CER2.1
#=GS A0A6J0AYP7_VICPA/525-573  AC A0A6J0AYP7.1
#=GS A0A2Y9Q144_DELLE/114-158  AC A0A2Y9Q144.1
#=GS A0A2K6LS44_RHIBE/526-574  AC A0A2K6LS44.1
#=GS A0A2K6CY74_MACNE/513-561  AC A0A2K6CY74.1
#=GS A0A2Y9PVM3_DELLE/145-189  AC A0A2Y9PVM3.1
#=GS A0A5F4VVX2_CALJA/485-533  AC A0A5F4VVX2.1
#=GS A0A6P6DAV2_OCTDE/546-594  AC A0A6P6DAV2.1
#=GS A0A341BYS0_NEOAA/560-608  AC A0A341BYS0.1
#=GS A0A287CUV1_ICTTR/455-502  AC A0A287CUV1.1
#=GS A0A673TQY8_SURSU/146-193  AC A0A673TQY8.1
#=GS A0A212CR36_CEREH/33-81    AC A0A212CR36.1
#=GS A0A1U7U9P9_CARSF/518-566  AC A0A1U7U9P9.1
#=GS A0A1U7QVF6_MESAU/531-578  AC A0A1U7QVF6.1
#=GS A0A2Y9FZP0_TRIMA/478-526  AC A0A2Y9FZP0.1
#=GS A0A0D9RRE3_CHLSB/543-586  AC A0A0D9RRE3.1
#=GS A0A1S3FAA0_DIPOR/510-558  AC A0A1S3FAA0.1
#=GS A0A3Q7MTB9_CALUR/153-197  AC A0A3Q7MTB9.1
#=GS A0A6I8MXD1_ORNAN/223-266  AC A0A6I8MXD1.1
#=GS A0A2K6QCS9_RHIRO/526-574  AC A0A2K6QCS9.1
#=GS A0A3Q7RBZ8_VULVU/550-598  AC A0A3Q7RBZ8.1
#=GS A0A671FUN9_RHIFE/494-542  AC A0A671FUN9.1
#=GS A0A2K5IRK4_COLAP/542-590  AC A0A2K5IRK4.1
#=GS G1Q928_MYOLU/144-192      AC G1Q928.1
#=GS A0A452S6A7_URSAM/549-597  AC A0A452S6A7.1
#=GS Q99JA1_CAVPO/504-552      AC Q99JA1.1
#=GS F1S0J1_PIG/145-192        AC F1S0J1.3
#=GS A0A383ZHT1_BALAS/130-178  AC A0A383ZHT1.1
#=GS A0A5F5Y5F1_FELCA/543-591  AC A0A5F5Y5F1.1
#=GS A0A5N3XW54_MUNRE/549-597  AC A0A5N3XW54.1
#=GS A0A5E4AFC8_MARMO/473-520  AC A0A5E4AFC8.1
#=GS A0A5F8GCZ4_MONDO/540-588  AC A0A5F8GCZ4.1
#=GS A0A2K6N701_RHIRO/522-570  AC A0A2K6N701.1
#=GS A0A4W2EDP9_BOBOX/145-193  AC A0A4W2EDP9.1
#=GS A0A091DA21_FUKDA/122-170  AC A0A091DA21.1
#=GS A0A6J3ISE6_SAPAP/515-563  AC A0A6J3ISE6.1
#=GS A0A096N7V3_PAPAN/541-589  AC A0A096N7V3.2
#=GS H2Q114_PANTR/541-589      AC H2Q114.1
#=GS A0A6J0ZDS1_ODOVR/559-607  AC A0A6J0ZDS1.1
#=GS I3LKJ7_PIG/145-191        AC I3LKJ7.1
#=GS A0A1S3WM49_ERIEU/524-567  AC A0A1S3WM49.1
#=GS APOR_PIG/146-194          AC Q03472.1
#=GS L8ISI4_9CETA/544-588      AC L8ISI4.1
#=GS A0A643BQL5_BALPH/321-366  AC A0A643BQL5.1
#=GS A0A4U1FFF5_MONMO/89-129   AC A0A4U1FFF5.1
#=GS A0A6P6DA32_OCTDE/158-206  AC A0A6P6DA32.1
#=GS A0A2K5KKU7_CERAT/511-559  AC A0A2K5KKU7.1
#=GS A0A673THX3_SURSU/550-597  AC A0A673THX3.1
#=GS W5PBY2_SHEEP/545-593      AC W5PBY2.1
#=GS F6RNZ2_MACMU/542-590      AC F6RNZ2.3
#=GS A0A2I3HSK4_NOMLE/491-540  AC A0A2I3HSK4.1
#=GS A0A3P4KE56_GULGU/153-197  AC A0A3P4KE56.1
#=GS A0A455B568_PHYMC/633-681  AC A0A455B568.1
#=GS A0A212CQV1_CEREH/146-193  AC A0A212CQV1.1
#=GS A0A3Q7V0T4_URSAR/542-590  AC A0A3Q7V0T4.1
#=GS A0A673TQ24_SURSU/550-597  AC A0A673TQ24.1
#=GS A0A6P6DA69_OCTDE/550-598  AC A0A6P6DA69.1
#=GS A0A7N5K740_AILME/152-196  AC A0A7N5K740.1
#=GS A0A673THP4_SURSU/550-597  AC A0A673THP4.1
#=GS G1Q6X8_MYOLU/145-192      AC G1Q6X8.1
#=GS A0A1A6FSZ9_NEOLE/57-85    AC A0A1A6FSZ9.1
#=GS A0A7N9D6B3_MACFA/549-597  AC A0A7N9D6B3.1
#=GS A0A091CQS3_FUKDA/544-592  AC A0A091CQS3.1
#=GS A0A2K5UC58_MACFA/542-590  AC A0A2K5UC58.2
#=GS A0A6P6DAA7_OCTDE/538-586  AC A0A6P6DAA7.1
#=GS A0A091CNR6_FUKDA/140-188  AC A0A091CNR6.1
#=GS F6YWC0_HORSE/145-189      AC F6YWC0.2
#=GS A0A383Z8S9_BALAS/145-189  AC A0A383Z8S9.1
#=GS A0A452C9I6_BALAS/560-608  AC A0A452C9I6.1
#=GS A0A6P3FJW4_OCTDE/534-582  AC A0A6P3FJW4.1
#=GS Q5M891_RAT/547-595        AC Q5M891.1
#=GS A0A6I9ZZW2_ACIJB/146-189  AC A0A6I9ZZW2.1
#=GS F1S0J2_PIG/559-607        AC F1S0J2.4
#=GS A0A4W2EK29_BOBOX/544-592  AC A0A4W2EK29.1
#=GS A0A4W2EDQ6_BOBOX/562-610  AC A0A4W2EDQ6.1
#=GS A0A2Y9GLC3_NEOSC/542-590  AC A0A2Y9GLC3.1
#=GS A0A1U7QIZ2_MESAU/512-559  AC A0A1U7QIZ2.1
#=GS L8IV53_9CETA/539-587      AC L8IV53.1
#=GS A0A2R8ZDJ2_PANPA/498-546  AC A0A2R8ZDJ2.1
#=GS A0A6I9J3F7_CHRAS/99-147   AC A0A6I9J3F7.1
#=GS A0A455BJ22_PHYMC/324-368  AC A0A455BJ22.1
#=GS A0A6I8N0Y3_ORNAN/218-261  AC A0A6I8N0Y3.1
#=GS A0A5E4AFV9_MARMO/145-193  AC A0A5E4AFV9.1
#=GS A0A2K5UC72_MACFA/513-561  AC A0A2K5UC72.1
#=GS A0A383Z8T4_BALAS/537-585  AC A0A383Z8T4.1
#=GS A0A3Q7U8D8_URSAR/209-256  AC A0A3Q7U8D8.1
#=GS A0A671FZS1_RHIFE/551-598  AC A0A671FZS1.1
#=GS A0A1S3FA95_DIPOR/573-621  AC A0A1S3FA95.1
#=GS A0A6G1AJA6_CROCR/542-590  AC A0A6G1AJA6.1
#=GS A0A287BTH4_PIG/546-569    AC A0A287BTH4.2
#=GS A0A6I8NN51_ORNAN/469-516  AC A0A6I8NN51.1
#=GS A0A4U1FFD5_MONMO/128-172  AC A0A4U1FFD5.1
#=GS L9JBT2_TUPCH/1247-1295    AC L9JBT2.1
#=GS F7EUY5_RAT/466-514        AC F7EUY5.1
#=GS F7IKA2_CALJA/543-591      AC F7IKA2.2
#=GS A0A5F5Y442_FELCA/543-591  AC A0A5F5Y442.1
#=GS G1QE87_MYOLU/127-175      AC G1QE87.1
#=GS A0A384BL34_URSMA/152-196  AC A0A384BL34.1
#=GS G1T7A2_RABIT/579-627      AC G1T7A2.2
#=GS A0A384BL46_URSMA/549-597  AC A0A384BL46.1
#=GS A0A2U4CQH8_TURTR/145-189  AC A0A2U4CQH8.2
#=GS A0A096MUS6_PAPAN/516-564  AC A0A096MUS6.2
#=GS A0A673TQI4_SURSU/550-597  AC A0A673TQI4.1
#=GS G3R980_GORGO/543-591      AC G3R980.2
#=GS A0A3Q7MSQ8_CALUR/543-590  AC A0A3Q7MSQ8.1
#=GS A0A1D5Q9A4_MACMU/550-598  AC A0A1D5Q9A4.2
#=GS A0A287D117_ICTTR/405-452  AC A0A287D117.1
#=GS A0A5N3XV44_MUNRE/127-175  AC A0A5N3XV44.1
#=GS A0A452FQ19_CAPHI/545-593  AC A0A452FQ19.1
#=GS G3GZR7_CRIGR/731-778      AC G3GZR7.1
#=GS A0A7N4NTC0_SARHA/477-525  AC A0A7N4NTC0.1
#=GS A0A6I8NYI7_ORNAN/545-592  AC A0A6I8NYI7.1
#=GS A0A3Q1LYJ0_BOVIN/142-186  AC A0A3Q1LYJ0.1
#=GS G3TWW5_LOXAF/145-190      AC G3TWW5.1
#=GS A0A384BKZ9_URSMA/147-194  AC A0A384BKZ9.1
#=GS A0A671G341_RHIFE/551-599  AC A0A671G341.1
#=GS A0A5F5XEP4_FELCA/146-189  AC A0A5F5XEP4.1
#=GS A0A3Q7TK50_URSAR/147-194  AC A0A3Q7TK50.1
#=GS A0A6P6HMR3_PUMCO/544-591  AC A0A6P6HMR3.1
#=GS A0A6J2N8P6_9CHIR/551-599  AC A0A6J2N8P6.1
#=GS G1P9A5_MYOLU/553-600      AC G1P9A5.1
#=GS A0A2K5YCP5_MANLE/541-589  AC A0A2K5YCP5.1
#=GS A0A6P5LKW2_PHACI/545-593  AC A0A6P5LKW2.1
#=GS A0A6P6DBB7_OCTDE/145-193  AC A0A6P6DBB7.1
#=GS S9XGK8_CAMFR/1054-1102    AC S9XGK8.1
#=GS G3N0S9_BOVIN/139-190      AC G3N0S9.2
G1L9X2_AILME/550-597                 .........-VPESCEY.VGKGRKIMQCLPNPADVKMALELYRYSLEI....EVLER.QIEKVK......
A0A4W2CZQ0_BOBOX/550-598             .........EYPEGCEQ.VVTGRKLLKCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A452C9N0_BALAS/578-626             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
A0A2U3XG79_LEPWE/542-590             ........v-VPEGCEH.VHKGRKAMQCLPNSADVKMAMELYKLSLEI....EVLEL.QRDKAK......
ZP3R_CAVPO/468-515                   .........EVPEECKQ.VAAGRKLLECLPNPSDVKMALEVYKLSLEI....EQLEK.E-----kyvk..
E9PZ07_MOUSE/468-515                 .........EVLEDCRI.VSRGAQLLHCLSSPEDVHRALKVYKLFLEI....ERLEH.QKEK--w.....
A0A2Y9Q1I2_DELLE/49-89               ........g--TEDCEI.VLKGQKLIQCISSPQDSKAFLELHKLSLEI....EKLE-.------......
A0A383Z974_BALAS/609-657             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
A0A2K5UC71_MACFA/542-590             .........ETPEGCEQ.VLAGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A673TR05_SURSU/147-194             .........-VPEGCEH.VLASRKVMQCLPNPEDLKIGLELYKLSLET....ELLEL.QRDKAR......
A0A7E6CWT8_9CHIR/145-188             .........EVHNGCEE.VVDGRKLLQCLPNPEDVKMALEVYKLSLEI....KRLKQ.E-----......
A0A6I8P2W5_ORNAN/492-539             .........-IPEGCEQ.VQAGQAILKCLPNPGDVIQALEAYKLSLEI....AKLEL.EVDH--lr....
A0A5F9CJA1_RABIT/541-589             .........EVPEGCEQ.VQAGRRLMQCLADPYEVKMALEVYKLSLEI....ELLEL.QRDKAR......
A0A643BQK8_BALPH/161-205             .........EVRTGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLKL.Q-----t.....
A0A5N4CI57_CAMDR/474-522             ........v-YPEGCEQ.VLVARELMQCLPNPEEVKLALEVYKLSLEI....EILKL.QRDKEK......
A0A6P6DA41_OCTDE/495-542             .........EVPADCKQ.VTAGQKLMECLPSPADVKMALEIYKLSLEI....ETLEK.------gkymk.
H2N3W0_PONAB/558-606                 .........ETPEGCEQ.VLTGKRLMQCLPNPENVKMALEVYKLSLEI....EQLEL.QRDSAR......
A0A2K6LS37_RHIBE/526-574             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A2K5CS31_AOTNA/544-592             .........ETPEGCEQ.VLAGQNLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A2R9BXJ3_PANPA/541-589             .........ETPEGCEQ.VLTGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDSAR......
A0A3Q7MV65_CALUR/565-612             .........-IPEGCEH.VQKGRTAMQCLPNPADVKMAMELYKLSLEI....ELLEL.QRDKAK......
C4BPA_MOUSE/416-464                  .........EASEDLKP.ALTGNKTMQYVPNSHDVKMALEIYKLTLEV....ELLQL.QIQKEK......
A0A3P4N1A1_GULGU/120-167             .........-IPEGCEH.VLKGTKIMQCLPNPAHVKMAMELYKLSLEI....ELLEL.QRDKAK......
A0A2K5ZIZ4_MANLE/516-564             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A2K6CCW8_MACNE/542-590             .........ETPEGCEQ.VLAGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A6J0Z918_ODOVR/699-747             .........EYPEGCEQ.VIAGRKLLQCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKRK......
A0A452E9D0_CAPHI/496-548             .........EYPECCEQ.AVTGRKLLQCLSRPVEVKLALEVYKLSLETgqelQLLEL.QLEK--pn....
A0A6I9IZX7_CHRAS/145-187             ........k-VPEGCDQ.VLAGRNLMQCLPNPQDVKMALELYKLSLEI....KQLE-.------y.....
W5PDE5_SHEEP/146-193                 .......pv---ELCEA.VLKGQKLLKCLPNAWEAKVALELHKLSLEI....EKLEQ.EKRKK-i.....
A0A673TQG4_SURSU/145-189             .........EDPKSCEQ.VLAGKKIQQCLPNPEDVKMALEIYKLSMEI....QHLH-.------nss...
A0A287A7D4_PIG/488-536               .........EYPEDCEQ.VHEGKKLMQCLPNPEEIKLALELYKLSLEI....KLLKR.QIDE--ka....
A0A383Z8U7_BALAS/577-625             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
A0A340YCM8_LIPVE/609-657             .........EYAEGCEQ.VVKGKKLMQCLPTPEEVRLALEVYKLYLEI....QKLEL.QKDEAK......
A0A383Z9M6_BALAS/559-607             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
G3V902_RAT/510-558                   .........EGPEDCEI.VNKGRQLLQCLSSPEDVQRALEVYKLSLEI....ERLEQ.QREK--rt....
Q1RMN9_BOVIN/145-193                 .........EYPEGCEQ.VVTGRKLLKCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A671FUB3_RHIFE/145-188             .........EVHNGCEQ.VLAGSKLMQCLPNLEDVKMALEVYKLSLEI....KRLKQ.E-----......
A0A6P3IKM6_BISBI/145-193             .........EYPEGCEQ.VVTGRKLLKCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A2U3X0R2_ODORO/153-197             .........EFQMGCEQ.VLVGSKLLQCLPYPEDVKKALEVYKLSLEI....GHL--.------ckne..
A0A6J3R270_TURTR/537-585             .........EYPEGCEQ.VVKGKKLMQCLPDPQEVKLALEVYKLYLEI....QTLEL.QKDEAK......
A0A452RCD0_URSAM/152-196             .........EYQMGCEQ.VLAGNKLLQCLPNPEDVKRALEVYRLSLEI....GHL--.------insq..
E9PVX4_MOUSE/447-494                 .........EVLEDCRI.VSRGAQLLHCLSSPEDVHRALKVYKLFLEI....ERLEH.QKEK--w.....
A0A2I2YKD7_GORGO/510-558             .........ETPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
C4BPA_RAT/504-552                    .........EVPKDCEH.VFAGKKLMQCLPNSNDVKMALEVYKLTLEI....KQLQL.QIDKAK......
G3X2N5_SARHA/520-568                 .........EFSEGCEK.VSVGYKLMQCLPNSQDVKLALEIEKLSLEI....ELLKQ.AIGKNK......
G1TPZ5_RABIT/492-540                 .........EMAEECEQ.VMVGRKLLQCLPTPEDVKMALSVYKLSLEI....ERLEQ.ENTQN-m.....
A0A671FUS6_RHIFE/145-192             .........EVPEGCER.VLAGRNITQCLSNVADVKMALEVYKLSLEI....ELLEL.QLHK--g.....
A0A5F5Y0X6_FELCA/146-194             ........v-VPEGCEH.MLAGRKVMQCLPNPEDLKISLEMYKLSLEI....ELLEL.QRDNAR......
A0A6I9J0S4_CHRAS/541-589             .........EVPEGCEK.ILAGRNFMQCLPNPQDVKLAMELYKLSLEI....EQLER.ERDKAM......
A0A7E6CXM8_9CHIR/551-599             .........EFPSGCEQ.VKAGRKLMQCLPRPEDVKMALEVYKLSLEI....ERLER.EREKAR......
A0A3Q1NK73_BOVIN/143-187             .......hw---EVCEQ.VHTGRHFRQCLPSLQDMKTTLELYKLSLRT....RR---.------fllkdt
F6SZ76_ORNAN/545-592                 .........-IPEGCEQ.VQAGQAILKCLPNPGDVIQALEAYKLSLEI....AKLEL.EVDH--lr....
A0A1S3F805_DIPOR/510-558             ........d-VPEGCEQ.VLEGRKLMQCLPSAEEVKMALEIYKLSLEI....ELLEL.QRDKAR......
L9JB00_TUPCH/145-190                 ........v-FPEGCEQ.VLAGRKLMQCLPNPEDVKMALEVYKLSLEI....ERLEK.------tlc...
A0A2K5Q4R0_CEBIM/489-536             .........EVSEGCEQ.VLTGRKLMQCLPSPEDVKMALEVYKLSLEI....EQLEK.ERDK--l.....
A0A2K6GP77_PROCO/540-588             .........EVVEGCEQ.VLTGRKLTQCLPRPEDVKMALEVYKLSLEI....ELLEL.QRDKAR......
M3WJK3_FELCA/544-591                 .........-IPEGCGH.VLAGRKVMQCLPNPEDVKMALEVYKLSLEI....ELLEI.QRDKAR......
A0A4V5P9J4_MONMO/427-475             .........EYPEGCEQ.VVKGKKLMQCLPNPEEVRLALEVYKLYLEI....QTLEL.QKDEAK......
A0A2K6U658_SAIBB/545-593             .........ETPEGCEQ.VLAGKYLMQCLPNPEDVKMALEVYKLSLEI....KQLEL.QRERER......
A0A4W2E482_BOBOX/139-190             ....cekvs--AEVCEA.VFKGQKLLKCLPNAMEAKVALELHKLSLEI....EKLEQ.EKRK--le....
A0A4W2CIV1_BOBOX/550-598             .........EYPEGCEQ.VVTGRKLLKCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A2Y9PVL3_DELLE/559-607             .........EYPEGCEQ.VVKGKKLMQCLPNPEEVRLALEVYKLYLEI....QTLEL.QKDEAK......
A0A3Q1LUK9_BOVIN/501-549             .........EYPEGCEQ.VVTGRKLLQCLSRPEEVKLALEVYKLSLEI....EILQT.NKLK--ke....
A0A452C960_BALAS/591-639             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
A0A6J0CSM0_PERMB/509-555             .......vl---EHCRP.VTEGKKRLQCFSNPEDVKNALEVYKLFLEI....EILER.EKEK--w.....
F7DFU6_MONDO/521-569                 .........EFPEGCEK.VSAGYRLMQCLPNAQDVKMALEIYKIALEI....EMLKL.ELDKK-e.....
A0A6P3IN82_BISBI/142-193             ....cekvs--AEVCEA.VFKGQKLLKCLPNAMEAKVALELHKLSLEI....EKLEQ.EKRK--le....
F1PGM9_CANLF/550-598                 ........v-VPEGCEH.ILKGRKTMQCLPNPEDVKMALEIYKLSLDI....ELLEL.QRDRAK......
A0A1U7TXN9_CARSF/545-593             .........EVPEGCEQ.VLAGRRLMQCLLNPEDVKMALELYKLSLEI....DLLEL.QREKER......
A0A673TQX9_SURSU/147-194             .........-VPEGCEH.VLASRKVMQCLPNPEDLKIGLELYKLSLET....ELLEL.QRDKAR......
M3YEL9_MUSPF/550-597                 .........-IPEGCEH.VRKGRKIIQCLLNPVDVKMAMELYKLSLEI....ELLEL.QRDKEK......
A0A485N1Z9_LYNPA/543-591             ........v-VPEGCDH.MLAGRKVMQCLPNPEDLKISLEMYKLSLEI....ELLEL.QRDNAR......
S7NS32_MYOBR/164-207                 .........EVHNGCEQ.VVEGSKLMQCLPSPMDVKMALEVYKLSLEI....KRLKQ.E-----......
A0A6P3RME7_PTEVA/57-100              .........EIPNGCEQ.VLAGIKLMQCLPTPEEAKMALEVYKLSQEI....KRLK-.------ee....
A0A2Y9JUL8_ENHLU/549-596             .........-IPEDCER.VRKGRKVMQCLLNPGDVKMAMELYKLSLEI....ELLEL.QRNKEK......
A0A452RCA9_URSAM/153-201             ........v-VPESCEH.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKA-t.....
A0A2K5PFU7_CEBIM/544-592             .........ETPEGCEQ.VLAGKNLMQCLPNPGDVKMALELYKLSLEI....KQLEL.QRDRER......
A0A1S3F810_DIPOR/146-194             .........EIPEDRDV.VLAGRKFLQCLPTPRDSKMALELHKLSLQI....EKLKQ.DRDKEK......
A0A341BY82_NEOAA/145-189             .........EVLSGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
A0A2I3SBS7_PANTR/508-556             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
H0WP65_OTOGA/539-587                 .........EVAEGCEQ.VLAGRKLMQCLPNPEDVKMALELYKLSLEI....DLLEL.QRDKKK......
A0A5E4AHA1_MARMO/484-532             .........EFQEGCNQ.VYTGKKLLQCLPNPADVKMALEVSKLSLEI....ELLEL.QLNKER......
L8ITE6_9CETA/113-163                 ....cekvs--AEVCEA.VFKGQKLLKCLPNAMEAKVALELHKLSLEI....EKLEQ.EKRK--l.....
G3X970_MOUSE/512-559                 .........EVLEDCRI.VSRGAQLLHCLSSPEDVHRALKVYKLFLEI....ERLEH.QKEK--w.....
A0A340YJR7_LIPVE/145-189             .........EVLTGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
A0A212CRI8_CEREH/7-55                .........EYPEGCEQ.VIAGKKLLQCLSSPVEVKLALEVYKLSLEI....ALLEL.QIDKPK......
I3M890_ICTTR/484-532                 .........EFQEGCNQ.VYIGKKLLQCLPNPADVKMALEVSKLSLEI....ELLEL.QLNKER......
A0A6J0A2G5_ACIJB/544-591             .........-IPEGCGH.VLAGRKVMQCLPNPEDVKMALEVYKLSLEI....ELLEI.QRDKAR......
A0A341BX82_NEOAA/559-607             .........EYPEGCEQ.VVKGKKLMQCLPNPEEVRLALEVYKLYLEI....QTLEL.QKDE--ae....
A0A2K6S5N6_SAIBB/512-560             .........EVSEGCEQ.VLIGRKLMQCLPSPEDVKMALEMYKLSLEI....ERLEK.EREK--sv....
A0A2U3X0P5_ODORO/543-590             .........-IPEGCEH.VQKGRTAMHCLPNPEDVKMAMELYKLSLEI....ELLEL.QRDKAK......
A0A5F9CCJ6_RABIT/541-589             .........EVPEGCEQ.VQAGRRLMQCLADPNEVKMALEVYKLSLEI....ELLEL.QRDKAR......
C4BPA_BOVIN/544-592                  .........EYPEGCEQ.VVTGRKLLQCLSRPEEVKLALEVYKLSLEI....EILQT.NKLK--ke....
G3T0X1_LOXAF/505-553                 .........EVPEGCER.VLAGRNLMQCLPSPQDVKMALELYKLSLEI....EQLER.EGQR--th....
W5PBY0_SHEEP/559-607                 .........EYPEGCEQ.VITGRKLLQCLPRPEEVKLALEVYKLSLEI....ELLHT.EKLK--ks....
A0A4X2KW17_VOMUR/520-568             .........EFPEGCEK.VSAIYKIMQCLPNAQDVKMALEIHKLTLEI....EMLEL.EIGKKR......
G1QJR5_NOMLE/398-446                 .........ETPEGCEQ.VLTGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A2K5L395_CERAT/541-589             .........ETPEGCEQ.VLAGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
G5BP10_HETGA/418-464                 .........EVLEGCEQ.VIAGRKLMQCLSNPAEVQMALEVYKLSLEI....ELLQL.QIDK--......
ZP3R_MOUSE/512-559                   .........EVLEDCRI.VSRGAQLLHCLSSPEDVHRALKVYKLFLEI....ERLEH.QKEK--w.....
A0A5F9D993_RABIT/541-589             .........EVPEGCEQ.VQAGRRLMQCLADPNEVKMALEVYKLSLEI....ELLEL.QRDKAR......
A0A6J3IS89_SAPAP/544-592             .........ETPEGCEQ.VLAGKNLMQCLPNPEDVKMALELYKLSLEI....KQLEL.QRDRER......
A0A2Y9FW89_TRIMA/145-192             .........EVPQGCEQ.VLSGRHLMQCLPRPQDVQMALEVYKLSLEV....KQLEQ.SI----gpe...
A0A6G1AJG4_CROCR/183-222             ......nqm----GCEQ.VLVGKKLLQCLPYPEDVKMALEVYKLSVEI....QHL--.------......
C4BPA_HUMAN/541-589                  .........ETPEGCEQ.VLTGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDSAR......
#=GR C4BPA_HUMAN/541-589       SS    .........XX-SSHHH.HHHHHHHTTSSSSHHHHHHHHHHHHHHHHH....HHHHH.HHHHHH......
A0A6J0Z7P6_ODOVR/146-193             .......gd---EVCEA.VLKGQKLLKCLPNAWEAKVALELRKLSLEI....EKLEQ.ERRKE-e.....
A0A452C9P0_BALAS/489-537             .........EYPEGCEQ.VVKGKKLMQWLPTPEEVRLALEVYKLYLEI....QQLEL.QNDKAK......
L5MFL6_MYODS/522-569                 .........-FPAGCEQ.VIAGRKLMQCLSSVEDVKMALELYKLSLEI....DLLEQ.QRDKAK......
S7QEE1_MYOBR/503-550                 .........-VPAGCEQ.VIAGRELMQCLPSVEDVKMALELYKLSLEI....DILEL.QRDKAK......
A0A3Q2HVB6_HORSE/658-706             .........EIAEGCEQ.VLAGRKIMQCLPKPEDVRTALELYKLSLEI....KQLEK.KLEKE-e.....
M3YEL4_MUSPF/151-197                 .........EFQMGCEQ.VLAGSKFFQCLPYPDDVKKALEIYKLSLEI....GQLS-.------kseen.
A0A2K5I3J9_COLAP/512-560             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A7E6CWF9_9CHIR/125-168             .........EVHNGCEE.VVDGRKLLQCLPNPEDVKMALEVYKLSLEI....KRLKQ.E-----......
A0A2Y9PUN5_DELLE/560-608             .........EYPEGCEQ.VVKGKKLMQCLPNPEEVRLALEVYKLYLEI....QTLEL.QKDEAK......
A0A5F4BNP2_CANLF/475-523             ........v-VPEGCEH.ILKGRKTMQCLPNPEDVKMALEIYKLSLDI....ELLEL.QRDRAK......
ZP3R_RAT/510-558                     .........EGPEDCEI.VNKGRQLLQCLSSPEDVQRALEVYKLSLEI....ERLEQ.QREK--rt....
A0A3Q7VF55_URSAR/152-196             .........EYQMGCEQ.VLAGNKLLQCLPNPEDVKRALEVYRLSLAI....GHL--.------vnsq..
A0A2K5CER2_AOTNA/467-516             .........EVSEGCEQ.GLTGRKLVQCLPSPEDVKMALEVYKLSLEI....ERLEKrERD---kse...
A0A6J0AYP7_VICPA/525-573             ........v-YPEGCEQ.VLVARKLMQCLPNPEEVKLALEVYKLSLEI....EILKL.QRDKEK......
A0A2Y9Q144_DELLE/114-158             .........EVLSGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
A0A2K6LS44_RHIBE/526-574             .........ETPEGCEQ.VLAGKRLMQCFPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A2K6CY74_MACNE/513-561             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A2Y9PVM3_DELLE/145-189             .........EVLSGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
A0A5F4VVX2_CALJA/485-533             .........EVSEGCEQ.VLTGRRLMQYLPSPEDVKMALEVYKLSLEI....DRLEK.ERDK--sv....
A0A6P6DAV2_OCTDE/546-594             .........EVPEGCEQ.VVIGRKYMQCLTSPGEVQMALQLYKLSLEI....ELLRL.QIDKAM......
A0A341BYS0_NEOAA/560-608             .........EYPEGCEQ.VVKGKKLMQCLPNPEEVRLALEVYKLYLEI....QTLEL.QKDE--ae....
A0A287CUV1_ICTTR/455-502             .........EVPEGCEQ.VIIGRKLMQCLPNPEEVKMALQIYKLSLQI....ERLEQ.EKDK--c.....
A0A673TQY8_SURSU/146-193             .........-VPEGCEH.VLASRKVMQCLPNPEDLKIGLELYKLSLET....ELLEL.QRDKAR......
A0A212CR36_CEREH/33-81               .........EYPEGCEQ.VIAGKKLLQCLSSPEEVKLALEVYKLSLEI....ALLEL.QIDKRK......
A0A1U7U9P9_CARSF/518-566             .........EAPVGCEQ.VLAGRHLMQCLPSSEEVKMALEVYKLSLEI....EQLEQ.ERYK--lm....
A0A1U7QVF6_MESAU/531-578             ........l--EKDCEH.VFAGKRFMRCLPNPDDVKMALELYKLSLEI....ELLEL.QIEKAK......
A0A2Y9FZP0_TRIMA/478-526             .........EVPEGCEQ.VLAGRHLMQCLPSPQDVKMALDIYKLSLEI....EQLEQ.ERHM--qr....
A0A0D9RRE3_CHLSB/543-586             ......rvp------EQ.VLPGRKLMQCLPNPDNVKTALEVYKLSPEI....DLLEL.EIQ---d.....
A0A1S3FAA0_DIPOR/510-558             ........d-VPEGCEQ.VLEGRKLMHCLASAEEVKMALEMYKLSLEV....ELLEL.QRDKAR......
A0A3Q7MTB9_CALUR/153-197             .........EFQMGCEQ.VLVGSKLLQCLPYPEDVKKALEVYKLSLEI....GHL--.------ckne..
A0A6I8MXD1_ORNAN/223-266             ......rni-----CEV.VKEGIQLQKCQPRWEELKSSLEIKKLHLEN....EKLQL.ER----s.....
A0A2K6QCS9_RHIRO/526-574             .........ETPEGCEQ.VLAGKRLMQCFPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A3Q7RBZ8_VULVU/550-598             ........v-VPEGCEH.ILKGRKTMQCLPNPEDVKMALEIYKLSLEI....ELLEL.QRDRAK......
A0A671FUN9_RHIFE/494-542             .........EVPDGCER.VLAGRNITRCLSNVADVKMALEVYKLSLEI....ELLEL.QIDKER......
A0A2K5IRK4_COLAP/542-590             .........ETPEGCEQ.VLAGKRLMQCLPNREDVKMALEVYKLSLEI....EQLEL.QRDRAR......
G1Q928_MYOLU/144-192                 ........v-VPAGCEQ.VIAGRELTQCLPSVEDVKMALELYKLSLEI....ELLEL.QKDKAK......
A0A452S6A7_URSAM/549-597             ........v-VPESCEH.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKA-t.....
Q99JA1_CAVPO/504-552                 .........EVPENCEQ.VIVGKKLMKCLSNPDEAQMALQLYKLSLEA....ELLRL.QIVKAR......
F1S0J1_PIG/145-192                   .........EYPEDCEQ.VHEGKKLMQCLPNL-EIKLALELYKLSLET....KLLEL.QIDKEK......
A0A383ZHT1_BALAS/130-178             .........EYPEGCEQ.VVKGKKLMQWLPTPEEVRLALEVYKLYLEI....QQLEL.QNDKAK......
A0A5F5Y5F1_FELCA/543-591             ........v-VPEGCEH.MLAGRKVMQCLPNPEDLKISLEMYKLSLEI....ELLEL.QRDNAR......
A0A5N3XW54_MUNRE/549-597             .........EYPEGCEQ.VVAGRKLFQCLSRPEEVKMALEVYKLSLEI....ALLEL.QIDKPK......
A0A5E4AFC8_MARMO/473-520             .........EVPEGCEQ.VIIGRKLMQCLPNLEEVKMALQIYKLSLQI....ERLEQ.EKDK--c.....
A0A5F8GCZ4_MONDO/540-588             .........EFPEGCEK.VSAGYRLMQCLPNAQDVKMALEIYKIALEI....EMLKL.ELDKK-e.....
A0A2K6N701_RHIRO/522-570             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A4W2EDP9_BOBOX/145-193             .........EYPEGCEQ.VVTGRKLLKCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A091DA21_FUKDA/122-170             .........ELPEGCEQ.VVEGRKLMQCLPSPEDVKVALEVYKLSLEN....ELLEL.QRNKAR......
A0A6J3ISE6_SAPAP/515-563             .........EVSEGCEQ.VLTGRKLMQCLPSPEDVKMALEVYKLSLEI....EQLEK.ERDK--sv....
A0A096N7V3_PAPAN/541-589             .........ETPEGCEQ.VLAGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
H2Q114_PANTR/541-589                 .........ETPEGCEQ.VLTGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDSAR......
A0A6J0ZDS1_ODOVR/559-607             .........EYPEGCEQ.VVTGRKLLQCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
I3LKJ7_PIG/145-191                   .........EIHTDCEQ.VLEGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.DL----kl....
A0A1S3WM49_ERIEU/524-567             .........EMPVGCEQ.VLAGQRLLQCLPDREEVRLALEVYKLSLEI....RRLE-.------ea....
APOR_PIG/146-194                     .........EYPEDCEQ.VHEGKKLMQCLPNLEEIKLALELYKLSLET....KLLEL.QIDKEK......
L8ISI4_9CETA/544-588                 .........EYPEGCEQ.VVTGRKLLQCLSRPEEVKLALEVYKLSLEI....EILQT.------nk....
A0A643BQL5_BALPH/321-366             .........EVPEVCEQ.APTGRHLRQCLPSPQNVEMALELYKLSLKT....RCLLL.E-----el....
A0A4U1FFF5_MONMO/89-129              ........g--TEDCEI.VLKGQKLIQCISSPQDSKAFLELHKLSLEI....EKLE-.------......
A0A6P6DA32_OCTDE/158-206             .........EVPKGCEQ.VVAGRKLMQCLPSLEDVKMALEVYKLSLEN....ELLEL.QRDKPR......
A0A2K5KKU7_CERAT/511-559             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ESDK--lm....
A0A673THX3_SURSU/550-597             .........-VPEGCEH.VLASRKVMQCLPNPEDLKIGLELYKLSLET....ELLEL.QRDKAR......
W5PBY2_SHEEP/545-593                 .........EYPEGCEQ.VITGRKLLQCLPRPEEVKLALEVYKLSLEI....ELLHT.EKLK--ks....
F6RNZ2_MACMU/542-590                 .........ETPEGCEQ.VLAGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A2I3HSK4_NOMLE/491-540             .........EAPEGCEQqALPGRKLMQCFPNPDNVKMALEVYKLSPEI....DLLEL.EIQ---gkm...
A0A3P4KE56_GULGU/153-197             .........EFHMGCEQ.VLAGSKFFHCLPYPDDVKKALEIYKLSLEI....GQLS-.------kse...
A0A455B568_PHYMC/633-681             .........ESPEGCEQ.VVTGKKLMQCLPTPEEVRSALEVYKLYLEV....QQLEL.RKDE--as....
A0A212CQV1_CEREH/146-193             .......gd---EVCEA.VLKGQKLLKCLPNTWEAKLALELRKLSLEI....EKLEQ.ERRKE-e.....
A0A3Q7V0T4_URSAR/542-590             ........v-VPESCEH.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKAK......
A0A673TQ24_SURSU/550-597             .........-IPEGCEN.VLAGRKIMQCLPNPQDVKMALEVYKLFLEI....KLLEI.QTKQE-i.....
A0A6P6DA69_OCTDE/550-598             .........EVPEGCEQ.VVIGRKYMQCLTSPGEVQMALQLYKLSLEI....ELLRL.QIDKAM......
A0A7N5K740_AILME/152-196             .........EYQMGCEQ.VLVGNKLLQCLPYPEDVKRALEVYKLSLEI....GHL--.------iksq..
A0A673THP4_SURSU/550-597             .........-VPEGCEH.VLASRKVMQCLPNPEDLKIGLELYKLSLET....ELLEL.QRDKAR......
G1Q6X8_MYOLU/145-192                 .........EVHNGCEQ.VVEGSKLMQCLPSPTDVKMALEVYKLSLEI....KRLKQ.ED----qpk...
A0A1A6FSZ9_NEOLE/57-85               .........EASEDCEH.VFTGKKLMQCLPNSDDVKMAL---------....-----.------......
A0A7N9D6B3_MACFA/549-597             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A091CQS3_FUKDA/544-592             ........d-VPEGCEQ.VVTGRKLMQCLSSPAEVRMALEVYKLSLEI....ELLQL.QIDKAR......
A0A2K5UC58_MACFA/542-590             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A6P6DAA7_OCTDE/538-586             .........EVPEGCEQ.VVIGRKYMQCLTSPGEVQMALQLYKLSLEI....ELLRL.QIDKAM......
A0A091CNR6_FUKDA/140-188             ........q-APEDRNI.VQAGKNLLRCLPSPRDSKVALELHKLSLEI....EKLEQ.ERDKGK......
F6YWC0_HORSE/145-189                 .........EVPRGCQQ.ALTGSKLMQCLSRPEDVKMALEFYKLSLEI....QQMEQ.E-----t.....
A0A383Z8S9_BALAS/145-189             .........EVRTGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
A0A452C9I6_BALAS/560-608             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
A0A6P3FJW4_OCTDE/534-582             .........EVPEGCEQ.VVIGRKYMQCLTSPGEVQMALQLYKLSLEI....ELLRL.QIDKAM......
Q5M891_RAT/547-595                   .........EVPKDCEH.VFAGKKLMQCLPNSNDVKMALEVYKLTLEI....KQLQL.QIDKAK......
A0A6I9ZZW2_ACIJB/146-189             ......eqm----GCEQ.VLKGKKLLECLPSPEDVKMALEVYKLSVEI....ERLD-.------kss...
F1S0J2_PIG/559-607                   .........EYPEDCEQ.VHEGKKLMQCLPNPEEIKLALELYKLSLEI....KLLKR.QIDE--ka....
A0A4W2EK29_BOBOX/544-592             .........EYPEGCEQ.VVTGRKLLQCLSRPEEVKLALEVYKLSLEI....EILQT.NKLK--ke....
A0A4W2EDQ6_BOBOX/562-610             .........EYPEGCEQ.VVTGRKLLKCLSRPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A2Y9GLC3_NEOSC/542-590             ........v-VPEGCEH.VHKGRKAMQCLPNPANVKMAMELYKLSLEI....ELLEL.QRDKAK......
A0A1U7QIZ2_MESAU/512-559             .........EVLENCRE.VNEGRKLLQCLSNPEDVKMALEVYKLSLEI....ERLEE.EKEK--w.....
L8IV53_9CETA/539-587                 .........EYPEGCEQ.VVTGRKLLKCLSSPEEVKLALEVYKLSLEI....ALLEL.QIDKPK......
A0A2R8ZDJ2_PANPA/498-546             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLAK.ERDK--lm....
A0A6I9J3F7_CHRAS/99-147              evpgvpeil--------.-LSCQNVLQCLPNSQDSKVALELYKLSLEI....GNLEK.EIDKEK......
A0A455BJ22_PHYMC/324-368             .........EVPTGCEQ.VLAGRKLMQCLPRPEDVKMALEVYKLSLEI....ERLEQ.Q-----t.....
A0A6I8N0Y3_ORNAN/218-261             ......rni-----CEV.VKEGIQLQKCQPRWEELKSSLEIKKLHLEN....EKLQL.ER----s.....
A0A5E4AFV9_MARMO/145-193             .........EVPEGCEQ.VLSGRKLMQRLPSPEDVKVALEMYKLSLET....ELLEL.QRYKAR......
A0A2K5UC72_MACFA/513-561             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A383Z8T4_BALAS/537-585             .........EYPEGCEQ.VIKGKKLMQCLPTPEEVRLALEVYKLYVEI....QQLEL.QNDKAK......
A0A3Q7U8D8_URSAR/209-256             .........-VPESCEY.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKAK......
A0A671FZS1_RHIFE/551-598             .........EVPEGCER.VLAGRNITQCLSNVADVKMALEVYKLSLEI....ELLEL.QLHK--g.....
A0A1S3FA95_DIPOR/573-621             ........d-VPEGCEQ.VLEGRKLMQCLPSAEEVKMALEIYKLSLEI....ELLEL.QRDKAR......
A0A6G1AJA6_CROCR/542-590             ........v-VPEGCEN.VLAGRKMMQCLPNPEDVKMALEVYKLTLEI....ELLER.RIERPR......
A0A287BTH4_PIG/546-569               .........EYPEDCEQ.VHEGKKLMQCLPNLE---------------....-----.------r.....
A0A6I8NN51_ORNAN/469-516             .........-IPEGCEQ.VQAGQAILKCLPNPGDVIQALEAYKLSLEI....AKLEL.EVDH--lr....
A0A4U1FFD5_MONMO/128-172             .........EVLSGCEQ.VLAGRKLMQCLPSPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
L9JBT2_TUPCH/1247-1295               ........v-FPEGCEQ.VLAGRKLMQCLPNPEDVKMALEVYKLSLEI....ERLEQ.ERGM--ar....
F7EUY5_RAT/466-514                   .........EGPEDCEI.VNKGRQLLQCLSSPEDVQRALEVYKLSLEI....ERLEQ.QREK--rt....
F7IKA2_CALJA/543-591                 .........ETPEGCEQ.VLAGKNLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A5F5Y442_FELCA/543-591             ........v-VPEGCEH.MLAGRKVMQCLPNPEDLKISLEMYKLSLEI....ELLEL.QRDNAR......
G1QE87_MYOLU/127-175                 ........v-VPAGCEQ.VIAGRELMQCLPSVEDVKMALELYKLSLEI....ELLEL.QKDKAK......
A0A384BL34_URSMA/152-196             .........EYQMGCEQ.VLAGNKLLQCLPNPEDVKRALEVYRLSLAI....GHL--.------insq..
G1T7A2_RABIT/579-627                 .........EVPEGCEQ.VQAGRRLMQCLADPYEVKMALEVYKLSLEI....ELLEL.QRDKAR......
A0A384BL46_URSMA/549-597             ........v-VPESCEH.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKAK......
A0A2U4CQH8_TURTR/145-189             .........EVLSGCEQ.VLAGRKLMQCLPNPEDVKMALEVYKLSLEI....ERLEL.Q-----t.....
A0A096MUS6_PAPAN/516-564             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A673TQI4_SURSU/550-597             .........-VPEGCEH.VLASRKVMQCLPNPEDLKIGLELYKLSLET....ELLEL.QRDKAR......
G3R980_GORGO/543-591                 .........ETPEGCEQ.VLIGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDSAR......
A0A3Q7MSQ8_CALUR/543-590             .........-IPEGCEH.VQKGRTAMQCLPNPADVKMAMELYKLSLEI....ELLEL.QRDKAK......
A0A1D5Q9A4_MACMU/550-598             .........EAPEGCEQ.VLTGRKLMQCLPSPEDVKVALEVYKLSLEI....KQLEK.ERDK--lm....
A0A287D117_ICTTR/405-452             .........EVPEGCEQ.VIIGRKLMQCLPNPEEVKMALQIYKLSLQI....ERLEQ.EKDK--c.....
A0A5N3XV44_MUNRE/127-175             .........EYPEGCEQ.VVAGRKLFQCLSRPEEVKMALEVYKLSLEI....ALLEL.QREKRK......
A0A452FQ19_CAPHI/545-593             .........EYPEGCEQ.VITGRKLLQCLPRPEEVKLALEVYKLSLEI....ELLHT.EKLK--ks....
G3GZR7_CRIGR/731-778                 .......qe---KDCEH.VFAGKRFMQCLSNSADVKMALEVYKLSLEI....ELLEL.QIEKAK......
A0A7N4NTC0_SARHA/477-525             .........EFSEGCEK.VSVGYKLMQCLPNSQDVKLALEIEKLSLEI....ELLKQ.KEKK--sn....
A0A6I8NYI7_ORNAN/545-592             .........-IPEGCEQ.VQAGQAILKCLPNPGDVIQALEAYKLSLEI....AKLEL.EVDH--lr....
A0A3Q1LYJ0_BOVIN/142-186             .......hw---EVCEQ.VHTGRHFRQCLPSLQDMKTTLELYKLSLRT....RR---.------fllkdt
G3TWW5_LOXAF/145-190                 .........EAPEGCKQ.VLSGRYLMQCLPRPQDVKMALEVYKLSLEI....EQLA-.------rrvg..
A0A384BKZ9_URSMA/147-194             .........-VPESCEH.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKAK......
A0A671G341_RHIFE/551-599             .........EVPDGCER.VLAGRNITRCLSNVADVKMALEVYKLSLEI....ELLEL.QIDKER......
A0A5F5XEP4_FELCA/146-189             ......eqm----GCEQ.VLKGKKLLECLPSPEDVKMALEVYKLSVEI....ERLD-.------kss...
A0A3Q7TK50_URSAR/147-194             .........-VPESCEY.VGKGRKIMQCLPNPADVKTALELYKYSLEI....ELLER.QIEKAK......
A0A6P6HMR3_PUMCO/544-591             ........i--PKGCGH.VLAGRKVMQCLPNPEDVKMALEVYKLSLEI....ELLEI.ERDKAR......
A0A6J2N8P6_9CHIR/551-599             .........EFPSGCEQ.VKAGRKLMQCLPRPEDVKMALEVYKLSLEI....ERLER.EREKAR......
G1P9A5_MYOLU/553-600                 .........-VPAGCEQ.VIAGRELTQCLPSVEDVKMALELYKLSLEI....ELLEL.QRDKA-q.....
A0A2K5YCP5_MANLE/541-589             .........ETPEGCEQ.VLAGKRLMQCLPNPEDVKMALEVYKLSLEI....EQLEL.QRDRAR......
A0A6P5LKW2_PHACI/545-593             .........EFPEGCEK.VSAIYKFMQCLPNAQDVKMALEIHKLTLEI....EMLEL.EIRKKK......
A0A6P6DBB7_OCTDE/145-193             ........q-VPEDHNI.VEAGKNLLQCLPSPRDAKVALELRKLSLEI....EKLEQ.ERDKKK......
S9XGK8_CAMFR/1054-1102               ........v-YPEGCEQ.VLVARDLMQCLPNPEEVKLALEVYKLSLEI....EILKL.QRDKEK......
G3N0S9_BOVIN/139-190                 ....cekvs--AEVCEA.VFKGQKLLKCLPNAMEAKVALELHKLSLEI....EKLEQ.EKRK--le....
#=GC SS_cons                         .........XX-SSHHH.HHHHHHHTTSSSSHHHHHHHHHHHHHHHHH....HHHHH.HHHHHH......
#=GC seq_cons                        .........EhPEGCEQ.VlsG+KLMQCLPsPEDVKhALEVYKLSLEI....EhLEh.ph-K........
//
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