#=GF ID CDC13_N
#=GF AC PF16853.12
#=GF DE Cell division control protein 13 N-terminus
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE PDB:3oip
#=GF GA 27.00 27.00;
#=GF TC 45.70 45.70;
#=GF NC 20.60 18.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP Domain
#=GF CL CL0021
#=GF RN [1]
#=GF RM 20877309
#=GF RT Structural bases of dimerization of yeast telomere protein Cdc13
#=GF RT and its interaction with the catalytic subunit of DNA polymerase
#=GF RT alpha.
#=GF RA Sun J, Yang Y, Wan K, Mao N, Yu TY, Lin YC, DeZwaan DC, Freeman
#=GF RA BC, Lin JJ, Lue NF, Lei M;
#=GF RL Cell Res. 2011;21:258-274.
#=GF DR INTERPRO; IPR031749;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found at the N-terminus of fungal cell division
#=GF CC control protein 13 (CDC13). It has an OB type fold. It is
#=GF CC involved in dimerisation of CDC13 and in interaction of CDC13
#=GF CC with the catalytic subunit of DNA polymerase alpha, Pol1 [1].
#=GF SQ 24
#=GS A0A0C7N398_9SACH/8-218 AC A0A0C7N398.1
#=GS C5DD12_LACTC/8-218 AC C5DD12.1
#=GS G8ZLD5_TORDE/4-208 AC G8ZLD5.1
#=GS J5RQC4_SACK1/36-259 AC J5RQC4.1
#=GS I2H095_HENB6/23-221 AC I2H095.1
#=GS G0WFJ4_NAUDC/4-254 AC G0WFJ4.1
#=GS A0A1G4JCG8_9SACH/8-218 AC A0A1G4JCG8.1
#=GS G8JUM9_ERECY/4-217 AC G8JUM9.1
#=GS A0A7H9HQE6_9SACH/4-211 AC A0A7H9HQE6.1
#=GS A0A1X7R6V4_9SACH/7-217 AC A0A1X7R6V4.1
#=GS G0VEZ4_NAUCA/4-214 AC G0VEZ4.1
#=GS J7SB89_HUIN7/2-188 AC J7SB89.1
#=GS H2AW79_KAZAF/5-202 AC H2AW79.1
#=GS C5DTN9_ZYGRC/4-214 AC C5DTN9.1
#=GS CDC13_YEAST/14-241 AC P32797.2
#=GS Q6CJ70_KLULA/5-222 AC Q6CJ70.1
#=GS A0A376BB18_9ASCO/17-241 AC A0A376BB18.1
#=GS A0A1G4MJQ0_LACFM/7-216 AC A0A1G4MJQ0.1
#=GS A7TIB2_VANPO/4-214 AC A7TIB2.1
#=GS Q6FT40_CANGA/36-175 AC Q6FT40.1
#=GS A0A7H9B923_ZYGMR/3-200 AC A0A7H9B923.1
#=GS Q75E25_EREGS/4-217 AC Q75E25.1
#=GS A0A1G4K3Y4_9SACH/8-219 AC A0A1G4K3Y4.1
#=GS G8C1V8_TETPH/4-220 AC G8C1V8.1
A0A0C7N398_9SACH/8-218 .............e-YVFVKSPGELSSLL...SGDTM.VNRGIQFVSVLTDI.DFDPQTKCHLYFKNF..QHGD...TEEPDYTCRIIC......................NTTATLNLTRMTLSLFSQQFDLEFP.ENEAET....QFNLEHIHLDKLCFVLCKGA.....L...VGRGSSY..GI..........FLKGLRPIDLNTTLFAARDNDMGTAV................YEATKTIFDNLVKLNRNSKAQFKFVKLSNLTNE..MLRY...............FQARQESIQLINTK-......NPMYGAA-r......................
C5DD12_LACTC/8-218 .............g-LKYICDPLELKGFF...SEGEV.LRQDIEFVSVLTSI.DFNPKSRCLFQFSNF..RPGE...SVSPDYTCKITC......................NNVETLNLTKLTLSLVSQQFDLDFP.DLNDAE....GFYMKDIHLEKLCFVCCKGT.....F...VTCDNKG..GI..........FLQGLRIIDIHSSLFDPTKRDERSSI................SETVRVIFDNLVKLNDNSKAQFKFVKLQNYDTA..MRKY...............IQSRQESMLSLKEK-......NPLFGL--lk.....................
G8ZLD5_TORDE/4-208 ..............QYKYITSTAAYDEFP...LESCV.---AIEFVALLTSI.SYERTH-YLLELHNF..ADGN...PDKMPFLVKVRC......................SDQFAEKLARMTISLMFQCLEIDLP.DSILDE....HTPLNDIHLESLCFVKCQCL.....Y...LSKESKY..GV..........YLENIKPFNAASVMDLALNHKDGHI-................GKTIFNIMQNLIRMDTRFTSPFKFARLNNPPKD..FRRL...............IEKLK--ANQPALVN......NPLFTANR.......................
J5RQC4_SACK1/36-259 ............ar--VFVTSTKEFERYP...SKAIV.---PVQFVALLTSI.HLTETK-CLLSFSNF.mGGED...PVENRYIIKLKF......................KDRSSERLARMTISLLCQYFDIEFP.DLDSRS....ALVLEDIHLERLCFSSCKAL.....Y...VSKHGNY..TL..........FLEDIKPLDRMSVINIISTDSKLSGSngslsg...pslkphlKESLTDIFNNLIKINKDEKNCFKFVKLIDYDME..LKKF...............IQERQELLLQESKPKp....vDPFFVPNR.......................
I2H095_HENB6/23-221 nnnrhrhnqgrkls---------------...-----.--LNFEIIGVLLDIiKNATDNSTYLKLTDF..---Q...NNDYIYLVKLND......................--ETVDQ----DLSLIYDTFDLDH-.-----S....ISTLNDIYLNYICFIRCKVE.....HnfsMQNKNDNfiRM..........NANEIIPMEITEIVNTVSSTDATIY-................SKILMTILKQLITKDSDPTSPFKFIKLVNYNYE..FINF...............IKNLDLMLKHKNK-LpqktetNPLFIV--de.....................
G0WFJ4_NAUDC/4-254 .............s-CKFITSISELKKLP...TAEKI.---SIRFISLLTGI.KFNGSNSFLLELQDF..PNGV...PALSPYRVKIKYnstndklksdtaaateqtttteNNSSSFKLARMTISLLCQFFDIDIN.EFDINEkkkePFFIDEIHLEKICFIDCKCI.....Y...VSNGEKS..SL..........YLDDVKPIDISTAIKYATQDKRQPVSttstadttndddhvirDKLISNIFNNLIMIDNDIKSDFNFVKLANFNNE..LKEF...............IQERKLKLMEEKKRS......NPLFFFG-e......................
A0A1G4JCG8_9SACH/8-218 ..............SYKFIKKPKELADLF...PENGL.GNQNIEFVSVLTGI.DFDPASRCLLHFKNF..DSGD...KAEVDYTCRITC......................STAQTLTLTKMMLSLFSQHFDFDFP.ELDEGR....QLVVEDVHLEKLCFVDCKGT.....F...VSSGDRG..GI..........FLQGLRPIELSGSLFGAQEKEQKTDI................FETTKAIFDNLVRLNYNSKAQFKFVKLLNLSNE..MREY...............SQSRQEAFQLQNER-......NPIFGAS-r......................
G8JUM9_ERECY/4-217 ..............NYRYISKPSELLHYY...SKEEI.ITQKVEFISVLTRI.TFSSSADSLLYLQNF..EHGR...EDKVPYIARLAC......................KNSEQVRLVRMVLQLLFNNFGLDIS.ISDSDP....GFDIDNIYYKRLCFVRCKGT.....L...VTNQNKG..SI..........LLHEILSIDMNKELSNENVSSRKLSAv..............dWAVLNQIVDNLVKLDKHINHEFKIKKLLNCTTK..FREY...............LKFRMQRLESAHMHV......NPMFGMNK.......................
A0A7H9HQE6_9SACH/4-211 .............d-FKFITSTAAYDSFP...QGKCI.---PIEFIAVLTSI.SFRGSH-FLLELQNF..TNGE...LDIIPYVVRMRC......................TSDDSKKLAKMAITLLFELFGIDVP.EKILDD....SFQPENLHWQSLTFVNCKCL.....Y...RSIDRTY..SV..........VLDDIKPLKTGAAIDAALNERETLQ-................GKVLFRIFQNLILMDQKSSDQFKFARLNNYNID..FFKS...............IKEIRDIGKESTKPT.....tNPLFAA--th.....................
A0A1X7R6V4_9SACH/7-217 ...........yti----IDNLEDIERIP...AGKCI.---RIRFVAVLQDI.VCTKSS-LSFHLATF..---N...DNDDTFITRINI......................KDTFARRNAMFAFSLLKRTLNFNFL.QFPIDNq.tvDWKRRDIHINELRLVVVSTT.....F...VTNGSKS..SL..........FLDDLIPLNLIEQADIVWKYLQSNTVhve.........ndwlTPRVAILFKRLCKLDAEDKSLFQFKNLKNIEFQ..Q---...............---------------......--------rndclqkiinfyqsankkqqcrs
G0VEZ4_NAUCA/4-214 .............s-CVFITSPSQFQRFP...DSKQI.---SLRFVSLLTGI.KYNGKN-FILELSDF..-DNN...NVISPYRVKLRC......................SDENAKRLAQMTISLLCQFFDFEIP.ELRTLS...dPFFIDEIQLDRLCFINCKVI.....Y...IGKDDKY..SL..........FLDDIKPIDLNNAIRIARQLQSTLE-................QRTILKIFDNLIKLNNESRNGFKFVKLDNYNNE..FAQF...............IQEKQTMVNSRKKTTii..nnNPLFRS--hi.....................
J7SB89_HUIN7/2-188 ...........tyt---QIQSLNQFSKYA...DEHPV.---SVRITGCLTHV.EELSSG-FLLSLTRF..---E...PGKEDFKVKVHY......................GDSSDKRAANLVISLLAQLLNVSRA.------....DLQTPNLAHKRLFFVTCFAV.....Y...ISSNNSF..TL..........FLDDIKTHDLAVAVVESDVDNN----................---FMEVFQNMVTQSEDPVSDFHVQSLPEYQKNkpFNTL...............IQNLMK---------......--------dnrggkhllf.............
H2AW79_KAZAF/5-202 .............a-IKWVSSLHELEGQP...DKTPI.---EIQFISVLTSV.TSTCNY-YLLQLQDF..---N...ENNDCYKVKVRF......................NCSTSCRLARITISLIYHFFDINMY.---GKI....TMDIEDMHLRKLCFVKCTAT.....Y...ISSKGKS..AL..........YLNDIEPIRLNDAILATKEKDPA---................GEKLSQLFNDLIRYEESPENEFKFTKLSGSTSE..LFDF...............IENLKFNAIKSKLK-......DTLFS---nll....................
C5DTN9_ZYGRC/4-214 ...........scl---YVDSPAQIGEIV...GNCGC.----VRFVSLLTSV.ESRNEF-YCLEMNNF..AMGT...PTSIPYRPILPK......................RHADSARSAKMVIELICNWYNLDIP.ELQNGI....TFIKNRIHTQCLCFLECKVL.....Y...MATPSES..SQnqpfedpylgYLESVKPLSFTQAQELALEASTDV--................GKTIRSILQNLQLMHQNGSIGFNSNLIQQQQQQ..QQQQ...............QQQQQQLLLLQ-EQ-......--------sepkqv.................
CDC13_YEAST/14-241 ............nr--IFVSSSKDFEGYP...SKAIV.---PVQFVALLTSI.HLTETK-CLLGFSNFerRGDQ...SQEDQYLIKLKF......................KDRGSERLARITISLLCQYFDIELP.DLDSDSgaspTVILRDIHLERLCFSSCKAL.....Y...VSKHGNY..TL..........FLEDIKPLDLVSVISTISTKSTNSSKhsssel....isecdlNNSLVDIFNNLIEMNRDEKNRFKFVKLIHYDIE..LKKF...............VQDQQKVLSQKSKAAa....iNPFFVPNR.......................
Q6CJ70_KLULA/5-222 .............p-YEYIPGPECLNKYY...QHGSI.VSKPVHFISILSKV.AYTKNDKCLFHFDNF..TNGK...AGLNTYCGKIKN......................KSFECDVLLRMVLSSLFEKLGMQIA.GLDYSS....DFVLEELEKRYMGMISVKGL.....F...ITAYDKA..SL..........QIHELKLLDLKSYFDQSTADEYKLL-................KPSIEKLFRNLLKREKR-NADFQFKSLTSYCTE..MQSYld..........slvLQEAPPTRLLPKENTa...ivNPLFQLG-l......................
A0A376BB18_9ASCO/17-241 ............kr--LYISKPTDLQSFA...SDTPNfNTLHISFVAVLKSI.KFISGKNTILTFGTF..DNLE...NDKSQYTCFVSN......................--TESNSLSINLINILKEVYDITFP.DIGINT....TFYKQNIYLEHLCFLRCQAD.....F...TVESSKC..VI..........YLVNFKPILVV-RLDDIQEKQTY---................----ARIFKNLVRMDQDIKCDFKFVKLYNFDER..MNCYrekvlsvnlknslasLQRRQEEQKQLETST......--------ppfvpnnnllfvpnn........
A0A1G4MJQ0_LACFM/7-216 .............r-YEYVKSPSVLPHLH...DNLEC.VTFNIEFVSVLTAI.DFKPSSRCLLRFNNF..ENGK...EDAIPYACKIKC......................DTPETLNLTKMTLSLLSQPFDLDIP.CVDSPS....GFMMTHLYLERLCLAHVKGK.....F...TRNNKKG..SI..........LLQGIRPIDLQGVFSAKPSKQSNDH-................-SSIIRIFDNLIKLNNDSKAEFKFVKLVNYDTK..MKQF...............VQAREEKIRLQTNMR......NPIFGA--aa.....................
A7TIB2_VANPO/4-214 .............i-TKFVTSSSQLIDLI..eNESEK.ANVYVEFVSLFTSL.QYDSKTGFTLKFDSF..SNST...LNSSPFVVNFQE......................---PFSSDTRTKVLRLCDKFDIDLPiDFNSES...pSFSIENIYLEKLCFVNCIGR.....Y...AYNGIHP..VV..........FAEKIRPISLPSVMKLLTNKTVNET-................AFSLSSIFDNLINLNSNSNRSFKFVELENYEPK..FGEF...............IQGRQQNLAVQLKLK......NPLFSAS-r......................
Q6FT40_CANGA/36-175 .....deaqarevv---------------...-----.--------------.---------------..----...------------......................-----------------NECDLEV-.--SDTN....AFNITKIQLEKLCFVVAKCTssglqL...VNGDMTF..KL..........QPVDVKVLDINYIQENWNTLDKKK--................KDKISKILLALKKLDSDIKSEFNFVKLNNYKNT..LVHF...............LSGIK--MTKQ----......--------tkltsfftkqttmve........
A0A7H9B923_ZYGMR/3-200 ........dargnl---------------...-----.-SSRIDQVLVLTGL.KHDEKS-FALKLEKF..ADGK...RDTIPYLAELSY......................NDKNSRRLARLVLLLMCQLFELRID.GLDSDY....AFDLDDIHHTKLCLVKIAGL.....P...GRIDKYY..HI..........EPEEITPIDMDRAVEYAQNRQDTTY-................GMLIHDILGNLIEMNDDVRNTFQFDKLRNYDCT..ISDF...............IRSLRRSKVKQEEISl...mrNPIFDV--mr.....................
Q75E25_EREGS/4-217 ..............EYQYISRPAELLRFF...SSDDI.VAQKVEFVAVLTRI.VFTPSTSCVLMLQNF..EHGR...DDRIPYVVKLPC......................RTWEQSQLVAIVLKLLMHGFGLDTE.KVGDES....GFDLADIHIKHLCFARCRGK.....F...ITNDKNG..SI..........LLDEILGIDIDKELRNEAAGSQRLSNe..............dWGVVNKITDNLIRLDRDSSHRFNFNNLAHSTRQ..FIDY...............LKYRTERLTQVDLRM......NPMFGANQ.......................
A0A1G4K3Y4_9SACH/8-219 .............t-FQYINAPSQLADLI...SNTSV.VTQDIEFVSVLTSI.DFNPVSRCIFRFGNF..ENSGsngQSDHDYNCKILC......................QTPDTLNLTKMTLSLFSQQFDLELP.DSKDET....GFCIDGIYLERLCFVHCKGK.....F...VTSKGKG..SI..........FLQGLRAVDLHATLFTTGSVVESQL-................MKTVAHIFDQLVILNNVARAPFKFVKLFNYDNE..MKQF...............IQTRQEKLLIGR--R......NPLFGA--va.....................
G8C1V8_TETPH/4-220 .............r-FQYITSSSELEVLLgldEKRKQ.GRFYVEFISVLTSI.KYLKSSKCILKFQSF..NNNL...VYESPYEVIYEC......................-----------TSDEIIKKFDLDIA.EP-KGN....GFIVNDCHLQRLCFVICRGA.....C...VFNGIYP..VV..........VAEDLIPLDLSQVIEMLDTFKSDNYDknnyltk..dsivenkNLTVSKIFDNLIFMNAKKTEPFKFVKLEDYDMR..FKEV...............IQHRQLLLNDRIIKN......NPVYNPG-s......................
#=GC seq_cons ...............h.alsusppltph....spptl....tlcFVulLTuI.cassss.hlLphpsF..tssp...ssp.sYhs+lpp......................pstpstpLs+hslSLltphFDl-hs.chptss....sF.lccIaLc+LCFlpCKuh.....a...lsssscs..ul..........aLc-l+PlDlssslptspspppp...................tpsltpIFsNLlchspcspspFKFsKLtNaspc..hpca...............lQpppp.hhptpp........NPhFs..........................
//
