#=GF ID CagA
#=GF AC PF03507.16
#=GF DE CagA exotoxin phosphopeptide substrate mimic region
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_918 (release 7.0)
#=GF GA 25.00 25.00;
#=GF TC 25.10 70.90;
#=GF NC 23.50 19.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Motif
#=GF RN [1]
#=GF RM 19966800
#=GF RT Helicobacter pylori CagA inhibits PAR1-MARK family kinases by
#=GF RT mimicking host substrates.
#=GF RA Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE;
#=GF RL Nat Struct Mol Biol. 2010;17:130-132.
#=GF DR INTERPRO; IPR005169;
#=GF DR SO; 0001067; polypeptide_motif;
#=GF CC Helicobacter pylori is the most common world-wide infection and
#=GF CC plays an important role in pathogenesis of peptic ulcers. The
#=GF CC CagA (cytotoxin-associated gene A) protein is a cell-surface
#=GF CC antigen which may play a role in determining the relative
#=GF CC virulence of the viral strains. This entry represents the
#=GF CC phosphopeptide substrate mimic region of CagA [1].
#=GF SQ 2
#=GS CAGA_HELPY/940-978 AC P55980.1
#=GS CAGA_HELPY/940-978 DR PDB; 3IEC E; 948-961;
#=GS CAGA_HELPY/940-978 DR PDB; 3IEC H; 948-961;
#=GS CAGA_HELPY/940-978 DR PDB; 5X7B L; 970-976;
#=GS CAGA_HELPY/940-978 DR PDB; 5X94 L; 954-960;
#=GS CAGA_HELPY/940-978 DR PDB; 5X94 N; 950-960;
#=GS CAGA_HELPY/940-978 DR PDB; 5X94 O; 956-960;
#=GS CAGA_HELPY/940-978 DR PDB; 5X94 M; 955-960;
#=GS CAGA_HELPY/940-978 DR PDB; 3IEC F; 948-961;
#=GS CAGA_HELPY/940-978 DR PDB; 3IEC G; 948-961;
#=GS CAGA_HELPY/940-978 DR PDB; 5X7B N; 971-977;
#=GS CAGA_HELPY/979-1011 AC P55980.1
CAGA_HELPY/940-978 GGVGQAAGFPLKRHDKVDDLSKVGLSASPEPIYATIDDL
#=GR CAGA_HELPY/940-978 SS XXXXXXXXXBXXXXXXBSXTTXXXXXXXXXXEEE-B--X
CAGA_HELPY/979-1011 GG-----PFPLKRHDKVDDLSKVGRSRNQE-LAQKIDNL
#=GC SS_cons XXXXXXXXXBXXXXXXBSXTTXXXXXXXXXXEEE-B--X
#=GC seq_cons GG.....sFPLKRHDKVDDLSKVGhSts.E.lhtpIDsL
//
