#=GF ID   CagA
#=GF AC   PF03507.19
#=GF DE   CagA exotoxin phosphopeptide substrate mimic region
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_918 (release 7.0)
#=GF GA   25.00 25.00;
#=GF TC   26.30 57.80;
#=GF NC   24.90 19.10;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP   Motif
#=GF RN   [1]
#=GF RM   19966800
#=GF RT   Helicobacter pylori CagA inhibits PAR1-MARK family kinases by
#=GF RT   mimicking host substrates.
#=GF RA   Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE;
#=GF RL   Nat Struct Mol Biol. 2010;17:130-132.
#=GF DR   INTERPRO; IPR005169;
#=GF DR   SO; 0001067; polypeptide_motif;
#=GF CC   Helicobacter pylori is the most common world-wide infection and
#=GF CC   plays an important role in pathogenesis of peptic ulcers. The
#=GF CC   CagA (cytotoxin-associated gene A) protein is a cell-surface
#=GF CC   antigen which may play a role in determining the relative
#=GF CC   virulence of the viral strains. This entry represents the
#=GF CC   phosphopeptide substrate mimic region of CagA [1].
#=GF SQ   5
#=GS CAGA_HELPY/940-978      AC P55980.1
#=GS B5Z6S0_HELPG/975-1008   AC B5Z6S0.1
#=GS CAGA_HELPY/979-1011     AC P55980.1
#=GS B5Z6S0_HELPG/1009-1041  AC B5Z6S0.1
#=GS B5Z6S0_HELPG/936-974    AC B5Z6S0.1
CAGA_HELPY/940-978                 GGVGQAAGFPLKRHDKVDDLSKVGLSASPEPIYATIDDL
B5Z6S0_HELPG/975-1008              GG-----PFPLKRHDKVGDLSKVGLSVSPEPIYATIDDL
CAGA_HELPY/979-1011                GG-----PFPLKRHDKVDDLSKVGRSRNQE-LAQKIDNL
B5Z6S0_HELPG/1009-1041             GG-----PFPLKRHDKVGDLSKVGLSREQQ-LKQKIDNL
B5Z6S0_HELPG/936-974               GVVGQAVGFPLKRHDKVGDLSKVGQSVSPEPIYATIDDL
#=GC seq_cons                      GG.....PFPLKRHDKVGDLSKVGLSsSPEPIYATIDDL
//