GenomeNet

Database: Pfam
Entry: Chordopox_A33R
LinkDB: Chordopox_A33R
Original site: Chordopox_A33R 
#=GF ID   Chordopox_A33R
#=GF AC   PF05966.15
#=GF DE   Chordopoxvirus A33R protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_4799 (release 9.0)
#=GF GA   22.50 22.50;
#=GF TC   22.50 22.50;
#=GF NC   22.40 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0056
#=GF RN   [1]
#=GF RM   11752718
#=GF RT   Antibody-sensitive and antibody-resistant cell-to-cell spread by
#=GF RT   vaccinia virus: role of the A33R protein in antibody-resistant
#=GF RT   spread. 
#=GF RA   Law M, Hollinshead R, Smith GL; 
#=GF RL   J Gen Virol 2002;83:209-222.
#=GF RN   [2]
#=GF RM   12634370
#=GF RT   Mapping and functional analysis of interaction sites within the
#=GF RT   cytoplasmic domains of the vaccinia virus A33R and A36R envelope
#=GF RT   proteins. 
#=GF RA   Ward BM, Weisberg AS, Moss B; 
#=GF RL   J Virol 2003;77:4113-4126.
#=GF DR   INTERPRO; IPR009238;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Chordopoxvirus A33R proteins.
#=GF CC   A33R plays a role in promoting Ab-resistant cell-to-cell spread
#=GF CC   of virus [1] and interacts with A36R to incorporate the protein
#=GF CC   into the outer membrane of intracellular enveloped virions (IEV)
#=GF CC   [2].
#=GF SQ   29
#=GS F1AXE3_ORFV/3-164       AC F1AXE3.1
#=GS Q98308_MCV1/89-183      AC Q98308.1
#=GS D3IZQ8_9POXV/4-159      AC D3IZQ8.1
#=GS A0A3S7SW86_9POXV/6-192  AC A0A3S7SW86.1
#=GS Q775P5_CAMPS/1-184      AC Q775P5.1
#=GS Q9Q8I0_MYXVL/1-175      AC Q9Q8I0.1
#=GS A0A220T6I5_9POXV/3-181  AC A0A220T6I5.1
#=GS Q1HTR3_9POXV/20-193     AC Q1HTR3.1
#=GS A0A223FMX8_9POXV/1-185  AC A0A223FMX8.1
#=GS Q9JF63_VACCT/1-145      AC Q9JF63.1
#=GS Q8V3H7_SWPV1/1-185      AC Q8V3H7.1
#=GS G3EI31_9POXV/1-181      AC G3EI31.1
#=GS Q0NP54_9POXV/1-184      AC Q0NP54.1
#=GS Q08FM0_DPV83/6-192      AC Q08FM0.1
#=GS Q6TVL1_ORFSA/4-164      AC Q6TVL1.1
#=GS Q6TV79_9POXV/6-162      AC Q6TV79.1
#=GS Q9DHJ1_YLDV/8-186       AC Q9DHJ1.1
#=GS Q9Q8V7_RFVKA/1-172      AC Q9Q8V7.1
#=GS A0A6B9R5X2_9POXV/2-125  AC A0A6B9R5X2.1
#=GS A0A2U9QHU3_9POXV/6-198  AC A0A2U9QHU3.1
#=GS A33_VAR67/1-184         AC P0DON1.1
#=GS A0A097IW01_9POXV/3-181  AC A0A097IW01.1
#=GS A0A3F2YKS5_SHEVT/8-195  AC A0A3F2YKS5.1
#=GS A0A1L3IZN7_9POXV/1-180  AC A0A1L3IZN7.1
#=GS Q8QMS0_CWPXB/1-187      AC Q8QMS0.1
#=GS A33_VARV/1-184          AC P0DON2.1
#=GS Q80KX2_MONPV/1-181      AC Q80KX2.1
#=GS Q6TUP7_YMTV5/6-182      AC Q6TUP7.1
#=GS A33_VACCW/1-185         AC P68617.1
#=GS A33_VACCW/1-185         DR PDB; 3K7B A; 98-185;
#=GS A33_VACCW/1-185         DR PDB; 3K7B B; 96-184;
F1AXE3_ORFV/3-164                  ...............................................hntfeadsesannqyvas----------------------------VK-..-RQ.KTIRRYIK....M...F...FRIVAAIAIIVLAILVVLLALEL..DHCKQESA.....-......-HTHY.......TTN....--...--....-.-..--....-...-....-.--.---.RTC..E.G.L.APDNKWCLTKRY.PSTWDAANSLCSSI..GQTL..P..S..K.D..T..V.N..Ty.......pWLEQYLTGTWASKkGevfKSLGETA..........KIwNGAG.........AGQ.QEKEFFCVT---kl.......................................................................
Q98308_MCV1/89-183                 ......................................................qtrklpcdtlg-------------------------------..---.--------....-...-...-----------------------..--------.....-......-----.......---....--...--....-.-..--....-...-....-.--.---.SNC..T.G.I.RRGNMCLTAGTG.TVGYEEANASCSRI..GAQL..P..G..P.D..V..H.-..P.........LAKEYLDETWARN.G...SHFSEAP..........VM.HPSG.........DVN.GVRKYFCVTSV-.........................................................................
D3IZQ8_9POXV/4-159                 ntfdndseannnanyiasvkrqkairryvklffrftaaiaiivlailvvvlalsldqclhnehph-------------------------------..---.--------....-...-...-----------------------..--------.....-......-----.......---....--...--....-.-..--....-...-....-.DD.VYN.STC..D.G.I.PLGNKCLTLHTS.-STWEEANLSCGRL..GFHL..P..S..T.G..I..H.K..Kf.......pWLVTHLDGTWGST.K...NSIFNPT.........gET.QQVM.........GPQ.EVHKYFCVS---d........................................................................
A0A3S7SW86_9POXV/6-192             ................................................................i-TMEEGNDKKDVTENANSFVGSTIYGPKLK-..KTK.SKKSKWLS....I...C...LRVLVISSILSLMAVATTLALQY..SKCKAEYD.....S......ITNKQ.......SFD....SY...SL....V.T..PD....K...L....D.PR.SGC.KEC..Q.G.I.MFDGDCYQFNPE.HKTFSEASMDCAGK..GYSL..P..A..T.N..L..M.S..K.........WIGDYLESTWGEE.G...YGLSKERg........gNI.ESPD.........ASA.EKRNYFCVKSV-s........................................................................
Q775P5_CAMPS/1-184                 ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQG..K--.NKRKRVIG....I...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......VITDA.......TAV....AV...AS....S.T..HR....KvasS....T.TQ.YKHkESC..N.G.L.YYQGSCYIFHSD.YQLFSDAKANCTTE..SSTL..P..N..KsD..V..L.T..T.........WLIDYVEDTWGSD.G...NPITKTT.........sDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
Q9Q8I0_MYXVL/1-175                 .................................................................MSLHAN-DADESKDEEAAFIGSTIYGKKLKK..KHL.LKKVRCIV....I...L...LRVSIVTSIVSLMAIAAMLALQC..SNCEVITT.....S......ARIS-.......---....TY...SS....I.-..--....-...-....-.AH.YEA.STC..K.G.I.VFDASCYMFHKE.PKTFYEAGADCANQ..SAVL..P..F..K.T..P..K.E..H.........WMWDYLEGTWGVD.G...YGIVDSV..........DL.RTYD.........VST.EMRKYFCVKSFT.........................................................................
A0A220T6I5_9POXV/3-181             ..........................................................stniemf-------EEETPQNAASTFTGNTIYASKLK-..KQK.SSRHRQIG....I...C...LRVAVVISIVTLMGTSIALGLEV..MKLKAVEQ.....T......CTTSS.......TAA....LI...K-....-.-..--....-...K....D.DG.TYE.THC..N.G.L.VYDGDCYVKHAD.KKSFNDANNECTKT..KSQL..P..Q..T.S..V..S.S.vT.........WLRPHLVNTWNEE.G...TAFTNDY..........D-.KFID.........DSE.SEREYFCVTHL-y........................................................................
Q1HTR3_9POXV/20-193                .......................................................rrhplaargm-------------------------------..---.----ACAI....I...T...LRIMVLVSLVSLTTIVAALAVQL..RACRQQHE.....-......-GSAC.......AVT....GT...PR....I.L..PL....A...Q....GgGS.VSA.EEC..Q.G.I.YLDGQCLTRGGDgMVPLQTANTTCHSK..GGRL..P..S..Q.T..L..I.R..KdpaggnqvdWLLFYLQGTWTDE.G...GHFPSADqtrtkrstdeDG.DDDN.........THS.EVRGYYCI----n........................................................................
A0A223FMX8_9POXV/1-185             .............................................................mmtp-------EKVDVEDQTSVFS-ATVYGSKQSK..KN-.-KKKRALG....L...C...IRISIIVSLVSMISISAFLIVKL..NQCMSANE.....S......ASLTL.......STD....RVtsgSQ....H.V..SS....A...A....T.SG.VNF.DKC..E.G.L.VYQSNCYTLSTE.HKSFDEAKSACEDD..NATL..P..S..KtD..V..E.N..N.........WLINYMDDTWGEN.G...NPIVKEE.........kDE.YDID.........VTT.EVRKYFCVKKM-a........................................................................
Q9JF63_VACCT/1-145                 ................................................................m-------------------------------..---.--------....-...-...-----VISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDA.......AVA....VA...AA...sS.T..HR....KvasS....T.TQ.YDHkESC..N.G.L.YYQGSCYILHSD.YQLFSDAKANCTAE..SSTL..P..N..KsD..V..L.T..T.........WLIDYVEDTWGSN.G...NPITKTT.........sDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
Q8V3H7_SWPV1/1-185                 .................................................................MSVEVNMENVKSEDNATSFSGSTIYGNKLKK..KTN.KSKSRCLA....I...G...LRIAIITSLLSLIGIATTLALQY..NKCKSVIE.....-......-HNEQ.......SYN....NQ...DN....I.T..PD....A...N....Y.NI.VKLyTGC..Q.G.I.VYEYYCLRLVYE.PLSFDDAVKSCMKN..KGNL..P..S..S.D..L..M.K..T.........WLSDYLDGTWGEE.G...RGLSKEK..........TI.LEVD.........IST.ELRSHFCLESFY.........................................................................
G3EI31_9POXV/1-181                 ...............................................................mm-----NPENVDVDEETSIF-SATVYGGKNN-..---.KYKKNTLS....L...Y...IRLSMIVSLISMISISVFLTIKL..NKCISIED.....D......VYTKP.......STN....RV...VS....A.R..QL....S...S....S.HN.MDIfKKC..D.G.L.VYQSYCYILNIE.PKSFDDSKTSCEDT..NSTL..P..N..KtD..V..L.N..N.........WLINYTDDTWGQD.G...NPINKEE.........nDV.YEAD.........VTT.EVRKYFCVKKI-y........................................................................
Q0NP54_9POXV/1-184                 ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQR..KN-.-KRKRVIG....I...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDA......aAVA....AA...S-....S.T..HR....KvasS....T.TQ.YKHkENC..N.G.L.YYQGSCYIFHSD.YQLFSDAKANCTTE..SSTL..P..N..KsD..V..L.T..T.........WLIDYVEDTWGSD.G...NPITKTT.........sDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
Q08FM0_DPV83/6-192                 ................................................................i-TMEEGNDKKDVTETANSFVGSTIYGPKLK-..KTK.SKKSKWLS....I...C...LRVLVISSILSLMAVATTLALQY..SKCKAEYD.....S......ITNKQ.......SLD....SY...SL....V.T..PD....K...L....D.PR.FEC.KEC..Q.G.I.MFDGDCYQFNTE.HKTFSEASMDCAGK..GYSL..P..A..T.N..L..M.S..K.........WIGDYLESTWGEE.G...YGLSKERg........gNI.ESPD.........AST.EKRNYFCVKSV-s........................................................................
Q6TVL1_ORFSA/4-164                 ..............................................ntfetdsesannanyvasv-------------------------------..KRQ.KAIRRYIK....L...F...FRIVAAIAIIVLAILVVLLALEL..DKCKEQST.....-......---HQ.......DYH....H-...--....-.-..--....-...-....-.--.TTN.KTC..D.G.L.FPENKWCLTKFD.PFTLRQAKSMCTGI..GQTL..P..S..E.D..I..V.KlyP.........WLGKYLTGTWSDK.Gg.vFGSSGST..........SE.VWSG.........ASE.QEKAFFCVA---kl.......................................................................
Q6TV79_9POXV/6-162                 .................................................fgdndseaaanatyva---------------------------SVK-..-RQ.KAIRRCIK....L...F...FRLMAALAIIILAALVIILALAL..SDCRNTTC.....-......VID--.......-TN....SY...N-....-.-..--....-...-....-.--.---.RTC..D.G.I.NAGNRCLTLKY-.PDTWTNANERCKEL..GQRL..PkpS..D.N..E..K.Y..P.........WLTDYLVNTWGNI.N..eRVFGTSG..........GL.ESVT.........MDG.STNKYFCVD---dn.......................................................................
Q9DHJ1_YLDV/8-186                  ...............................................................vn--LDIEGDKLNSNENTNAFTGSTIYGSKLKKekNTK.SKKNKFFG....L...C...IRISIIISILSLMAITITLSLQV..NKYKSMVE.....-......--LNK.......DLN....DA...S-....-.-..--....-...-....-.VS.LSN.AEC..R.G.L.VYGNNCFIFNSE.PKTFDEALSDCNTK..NYFL..P..P..T.N..I..M.T..S.........WLSDYLEDTWSEE.G...TSLLKSNi.......efNS.DDID.........IST.EMRKYFCVKSF-.........................................................................
Q9Q8V7_RFVKA/1-172                 .................................................................MSLQEN-DVEDSKDEGAAFIGSTIYGNKLKK..KHL.IKKVKCVS....I...L...LRVSIVTSIVSLMAITAILALQC..STCDVVKT.....S......AHISS.......SIN....QY...E-....-.-..--....-...-....-.--.---.SEC..K.G.I.VFDSACYTLHKE.PKTFYEASEDCANQ..SAVL..P..F..K.T..L..K.D..H.........WMWDYLEGTWGVD.G...YGIVELV..........DL.NTYD.........VSV.EMRKYFCVKSFT.........................................................................
A0A6B9R5X2_9POXV/2-125             ...........................................................sivlsl-------------------------------..---.--------....-...-...-----------------------..--------.....-......----Q.......NYN....CQ...QE....LnI..CK....H...I....D.KI.HRN.ETC..Y.G.LpVGDGMCYMLQKQ.EETYHNAKKKCERQ..QMHL..P..D..S.S..T..C.KdyE.........WLCLYLEDTWSND.N...SKPFTNI..........DI.HDMTviissvgsaITS.VKRKFYCVR---dw.......................................................................
A0A2U9QHU3_9POXV/6-198             ........................................................itntgdeel-----------------SFISSN--ATKIK-..--S.KKFMSTLT....L...L...LRLGLITCLIILMVLVGYLAIEL..SECKKTSE.....VclsalrIPLDA.......SANyptpSYt.pHT....I.T..NH....N...T....D.NI.TSTsKQC..H.G.I.QLANGCYTLHAT.PTTLQNAITLCNNN..NGTL..P..D..K.D..TcnK.N..K.........WISPYLDGTWSND.G...EVFSSDCsti....klvTL.YGNN.........IATiQMKRYFCV----ik.......................................................................
A33_VAR67/1-184                    ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQG..K--.NKRKRVIG....I...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDA.......TAV....AA...AL....S.T..HR....K...Va.ssT.TQ.YKHqESC..N.G.L.YYQGSCYIFHSD.YQLFSDAKANCATE..SSTL..P..N..KsD..V..L.T..T.........WLIDYVEDTWGSD.G...NPITKTT.........tDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
A0A097IW01_9POXV/3-181             ........................................................lvdvdidek-------NEYEYDGNTNLFNGSTIYTKNKNK..KYL.NIKT---L....L...F...LRIIIILSVLTLLGTTTYMIIKY..NECSSSLN.....-......--IDT.......PT-....-V...SK....I.V..SC....K...D....G.DK.I-M.VQC..N.G.I.IHNNDCYVLNKE.S-TLNDAIEECNKT..NSTL..P..S..K.E..L..L.T..T.........WIGDYILDTWGSD.G...KAIVKYN.........iHL.NDDF.........TDI.EKRKYFCLKSIY.........................................................................
A0A3F2YKS5_SHEVT/8-195             ..........................................................sgtetdy----------DESNNFTAFTGSTIYGYGLKS..KKNiKKKVKLIN....F...C...IKISIMTSMVSLITITIILAFFN..NTCLNQFN.....-......EHKQY.......FLK....NP...NP....T.TysDD....D...T....E.SE.LNVyRSC..K.G.I.VYSGHCYTFNSE.PKSFNDAYDDCEKK..NSEL..P..S..N.N..L..M.N..D.........WISDYLDGTWGED.G...NVLFKEKn........qEL.EAID.........ISD.EMRSYYCVRSF-f........................................................................
A0A1L3IZN7_9POXV/1-180             ......................................................mslvdvdidek---------YGYDGDANLFNGSTIYTKNKNK..KYL.NMR--T-L....L...L...LRLIIIVSILTLLGTTTYMLFKY..NECYSSLN.....-......---DD.......S-P....VF...EK....I.V..SC....K...D....G.NK.I-I.VQC..N.G.I.IYNNNCYVLNKE.S-TISDAKEECSKS..NSTL..P..S..K.D..L..L.K..T.........WLSEYVLDTWGSD.G...KAIINYN.........iPT.NNDD........fTDV.EKRKYFCLKSIY.........................................................................
Q8QMS0_CWPXB/1-187                 ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQG..K--.NKRKRVIG....L...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDAavavaaaSSS....TN...RK....V.A..AS....S...T....T.QY.DHK.ESC..N.G.L.YYQGSCYIFHSD.YKSFSDAKANCTAE..SSTL..P..N..KsD..V..L.T..T.........WLIEYVEDTWGSD.G...NPITKTT.........sDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
A33_VARV/1-184                     ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQG..K--.NKRKRVIG....I...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDA.......TAV....AA...AL....S.T..HR....K...Va.ssT.TQ.YKHqESC..N.G.L.YYQGSCYIFHSD.YQLFSDAKANCATE..SSTL..P..N..KsD..V..L.T..T.........WLIDYVEDTWGSD.G...NPITKTT.........tDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
Q80KX2_MONPV/1-181                 ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQG..K--.NKRKRVIG....L...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDS.......AVA....VA...AA...sS.T..HR....K...Va.ssT.TQ.YDHkESC..N.G.L.YYQGSCYILHSD.YKSFEDAKANCAAE..SSTL..P..N..KsD..V..L.T..T.........WLIDYVEDTWGSD.G...NPITKTT.........sDY.QDSD.........VSQ.EVRKYFC-----t........................................................................
Q6TUP7_YMTV5/6-182                 .......................................................svnldtesge---------LNLGENTNAFTGSTIYGYKLK-..KSK.NKRINFFG....L...F...VRILVIISILSLMAITVTLSIQV..NKYKIIMK.....-......-TNKD.......-L-....--...--....-.-..--....K...V....T.SS.FKK.TYC..E.G.L.VYDNNCFIFYAI.PKTFDEALYDCNLK..NYFL..P..P..I.S..V..M.S..S.........WISNYLEDTWSEE.G...TGLLKNNng......llNT.NNID.........VST.EMRKYFCVKSF-.........................................................................
A33_VACCW/1-185                    ............................................................mmtpe-----------NDEEQTSVFSATVYGDKIQG..K--.NKRKRVIG....L...C...IRISMVISLLSMITMSAFLIVRL..NQCMSANE.....A......AITDA.......AVA....VA...AA...sS.T..HR....KvasS....T.TQ.YDHkESC..N.G.L.YYQGSCYILHSD.YQLFSDAKANCTAE..SSTL..P..N..KsD..V..L.I..T.........WLIDYVEDTWGSD.G...NPITKTT.........sDY.QDSD.........VSQ.EVRKYFCVKTM-n........................................................................
#=GR A33_VACCW/1-185         SS    ............................................................XXXXX-----------XXXXXXXXXXXXXXXXXXXX..X--.XXXXXXXX....X...X...XXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXX.....X......XXXXX.......XXX....XX...XX...XX.X..XX....XXXXX....X.XX.XX--S--..S.S.E.EETTEEEEEEEE.EEEHHHHHHHHHHT..T-B-..-..-..HHH..H..T.T..S.........TTHHHHCTSB-TT.S...SBB-SSS.........---.----.........GCC.-EEEEEEEEE--X........................................................................
#=GC SS_cons                       ............................................................XXXXX-----------XXXXXXXXXXXXXXXXXXXX..X--.XXXXXXXX....X...X...XXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXX.....X......XXXXX.......XXX....XX...XX...XX.X..XX....XXXXX....X.XX.XX--S--..S.S.E.EETTEEEEEEEE.EEEHHHHHHHHHHT..T-B-..-..-..HHH..H..T.T..S.........TTHHHHCTSB-TT.S...SBB-SSS.........---.----.........GCC.-EEEEEEEEE--X........................................................................
#=GC seq_cons                      .............................................................................ppptssh.uuTlYu.Klp...K...pp+p+hls....l...h...lRlshllSllShhshsshLhlpl..spChstpp.............hpct.......shs....sh...s.......h........t........s.sp.hpt.cpC..p.G.l.hapusCYhhps-..poFs-ApssCssp..uusL..P..s..c.s..l..h.s..s.........WLh-Yl-sTWGs-.G...sslscss..........ch.pssD.........lSp.EhRKYFCV+oh..........................................................................
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