#=GF ID CiaD
#=GF AC PF21862.1
#=GF DE CiaD-like protein
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Q0PAA2
#=GF GA 27.00 27.00;
#=GF TC 31.90 63.70;
#=GF NC 25.90 19.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 81514348 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 36671522
#=GF RT The Missing Pieces: The Role of Secretion Systems in
#=GF RT Campylobacter jejuni Virulence.
#=GF RA Gabbert AD, Mydosh JL, Talukdar PK, Gloss LM, McDermott JE,
#=GF RA Cooper KK, Clair GC, Konkel ME;
#=GF RL Biomolecules. 2023;13:135.
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry includes the CiaD protein from Campylobacter jejuni.
#=GF CC C. jejuni utilizes a cell binding and effector delivery
#=GF CC mechanism to invade host cells. The Cia proteins (effectors) are
#=GF CC exported from the bacterium's flagellar T3SS and are involved in
#=GF CC enhancing C. jejuni cell invasion [1]. This entry defines a pair
#=GF CC of highly conserved C-terminal alpha helices from the proteins.
#=GF CC Many members of the family also contain an N-terminal T3SS
#=GF CC signal.
#=GF SQ 66
#=GS A0A7H9CHK4_9BACT/115-167 AC A0A7H9CHK4.1
#=GS A0A7M1AUZ3_9BACT/57-110 AC A0A7M1AUZ3.1
#=GS A0A7S7LYA7_9BACT/56-109 AC A0A7S7LYA7.1
#=GS A0A1I5RVR4_9BACT/64-117 AC A0A1I5RVR4.1
#=GS A0A3D8J9R3_9HELI/43-96 AC A0A3D8J9R3.1
#=GS A0A842JES8_9BACT/113-166 AC A0A842JES8.1
#=GS A0A1B1U7I7_9HELI/25-78 AC A0A1B1U7I7.1
#=GS V8C9D2_9HELI/122-175 AC V8C9D2.1
#=GS C8PE33_9BACT/393-446 AC C8PE33.1
#=GS A0A347VN89_9HELI/31-100 AC A0A347VN89.1
#=GS A0A2D3WGQ2_9BACT/65-118 AC A0A2D3WGQ2.1
#=GS J0L743_9BACT/117-170 AC J0L743.1
#=GS A0A268T940_9HELI/34-87 AC A0A268T940.1
#=GS A0RPP9_CAMFF/59-112 AC A0RPP9.1
#=GS A0A0A8H1U8_9BACT/88-141 AC A0A0A8H1U8.1
#=GS O24974_HELPY/97-150 AC O24974.1
#=GS T0KCK8_9BACT/76-129 AC T0KCK8.1
#=GS D1B360_SULD5/68-121 AC D1B360.1
#=GS A0A292YDM6_9BACT/28-81 AC A0A292YDM6.1
#=GS A0A329ZKW2_9HELI/68-121 AC A0A329ZKW2.1
#=GS A0A099U2C7_9HELI/31-93 AC A0A099U2C7.1
#=GS D3UI53_HELM1/58-111 AC D3UI53.1
#=GS V8CF67_9HELI/83-136 AC V8CF67.1
#=GS Q30RK4_SULDN/51-104 AC Q30RK4.1
#=GS A0A3D8IW90_9HELI/41-94 AC A0A3D8IW90.1
#=GS A0A381DIH0_9BACT/60-113 AC A0A381DIH0.1
#=GS CIAD_CAMJE/110-163 AC Q0PAA2.1
#=GS A0A329ZV33_9HELI/107-160 AC A0A329ZV33.1
#=GS A0A6G5R3R1_9BACT/45-98 AC A0A6G5R3R1.1
#=GS A0A091AP17_9BACT/53-106 AC A0A091AP17.1
#=GS A7I2S2_CAMHC/153-206 AC A7I2S2.1
#=GS A0A3D8HXD8_9HELI/46-99 AC A0A3D8HXD8.1
#=GS A0A2P8R271_9BACT/49-102 AC A0A2P8R271.1
#=GS Q7VFR5_HELHP/63-116 AC Q7VFR5.1
#=GS A0A1B8J748_9HELI/162-215 AC A0A1B8J748.1
#=GS A7GXZ3_CAMC5/69-122 AC A7GXZ3.1
#=GS A0A5P8P0L0_9BACT/55-108 AC A0A5P8P0L0.1
#=GS S3YI90_9BACT/73-126 AC S3YI90.1
#=GS A0A2D3VR27_9BACT/58-111 AC A0A2D3VR27.1
#=GS A0A4V6DVT2_9BACT/87-140 AC A0A4V6DVT2.1
#=GS F8KPA9_HELBC/45-98 AC F8KPA9.1
#=GS C5ZYD9_9HELI/76-129 AC C5ZYD9.1
#=GS A0A268U2C7_9HELI/31-92 AC A0A268U2C7.1
#=GS A0A3G9H6W6_9BACT/66-119 AC A0A3G9H6W6.1
#=GS A0A1S6U7I3_9BACT/62-115 AC A0A1S6U7I3.1
#=GS Q7MR14_WOLSU/72-125 AC Q7MR14.1
#=GS A0A7M1LEM3_9BACT/43-96 AC A0A7M1LEM3.1
#=GS A0A6G5QH51_9BACT/62-115 AC A0A6G5QH51.1
#=GS A0A2A2GTS5_9HELI/117-168 AC A0A2A2GTS5.1
#=GS A0A1X9SQP8_9BACT/122-175 AC A0A1X9SQP8.1
#=GS A0A128EJV4_9BACT/144-197 AC A0A128EJV4.1
#=GS E0UT18_SULAO/50-103 AC E0UT18.1
#=GS A0A975B080_9BACT/56-109 AC A0A975B080.1
#=GS A0A222MY06_9BACT/89-142 AC A0A222MY06.1
#=GS A0A3D8IHC9_9HELI/55-108 AC A0A3D8IHC9.1
#=GS A0A6L5WLE0_9BACT/62-115 AC A0A6L5WLE0.1
#=GS A0A2W6MSK5_9HELI/75-128 AC A0A2W6MSK5.1
#=GS B6BJK2_SULGG/66-119 AC B6BJK2.1
#=GS T1DW23_9HELI/113-166 AC T1DW23.1
#=GS A0A4V6YSR6_9HELI/75-128 AC A0A4V6YSR6.1
#=GS I7HD87_9HELI/64-117 AC I7HD87.1
#=GS A0A3D8HUP5_9HELI/112-164 AC A0A3D8HUP5.1
#=GS E4U2R7_SULKY/64-117 AC E4U2R7.1
#=GS C3XI57_9HELI/31-93 AC C3XI57.1
#=GS A0A3D8IRL0_9HELI/31-92 AC A0A3D8IRL0.1
#=GS A0A2D3W431_9BACT/64-117 AC A0A2D3W431.1
A0A7H9CHK4_9BACT/115-167 ..p-DNEQEFLIKLKERIEVLFAGLN................-ANDENTAVRLDLTIRFLEFLLAKIQNRLEN...
A0A7M1AUZ3_9BACT/57-110 ..v-DNELLFLKSIRERLLVLFEGFQ................APNNANLEAKIDMTLNFLEYTLATIDERVK-v..
A0A7S7LYA7_9BACT/56-109 ...SSDEMIFLISMRERLLVLFEGFQ................APNNTNIEAKVDMTLNFLEYVLITLDERV--le.
A0A1I5RVR4_9BACT/64-117 ..i-QEECQFLESLRERLLVLFEGFQ................SPNNSSVESKIDLTLNFLEYLLALLDERIT-k..
A0A3D8J9R3_9HELI/43-96 iqi---DARFLELMREKTLVLFEGLQ................SSQTKNLSDKLDLVINYLEYQLSLIDEALEK...
A0A842JES8_9BACT/113-166 .ft--GEEIFLKNLKERILVLFEGLN................ATGEENLKDRLSLTLKFLEFVLANVENRLEN...
A0A1B1U7I7_9HELI/25-78 .ii--DEREFLLAKREKLLVLFEGLL................SPQTQSMEKKFELVVRYLQYLLSEIDKRLQE...
V8C9D2_9HELI/122-175 ..s-PSNIEFLEMLREKLLVLFEGLK................MPQMRDSKEKLDLVVNFLQYELCLLDDFLK-d..
C8PE33_9BACT/393-446 ..i-SSEAEFLSAIKERILVLFEGLN................AFEKGDLNARVELNLKFMEFLLASIENRLEN...
A0A347VN89_9HELI/31-100 ..n-TGEVEFLQSFKERIFVLFEGLKnndlwidnlsaddllkDSKEVQASAKLDLILGFLQFQLALIDSRLE-a..
A0A2D3WGQ2_9BACT/65-118 ..d-DKHKQFYLNLRERILVLFEGFQ................SPNNKNIEAKIDLTLNFLEYLLATIDEQLEK...
J0L743_9BACT/117-170 ...SSDEVEFLENILKKSATLIEGLK................SPELKSREAKCDITLKYLQFLNVEILNRLEK...
A0A268T940_9HELI/34-87 ..s-KDEFAILHALREKTLVLFEGLQ................SLQTKNLSGKLDLVINYLQYQLSIIDEKLGN...
A0RPP9_CAMFF/59-112 ..v-NSEIIFLKNLKERIGVLFEGLN................SSDNSNMELKLDLTIKFLEFALANIEHRLTN...
A0A0A8H1U8_9BACT/88-141 ..i-NNEEFFLKNIRERILVLFEGLK................NTKDEHLEKRLEITITFLEFLLAKIEDRLKK...
O24974_HELPY/97-150 ..i-SNERVFLKGLLERTLVLFKGMQ................ALEEKEAMKRLDLVARFLQYQLSTLEKRLE-s..
T0KCK8_9BACT/76-129 ..m-ESEESFLNSLRERMLVLFEGFQ................APNNTGIDAKVDMTLNFLEYVLANIDLRKE-e..
D1B360_SULD5/68-121 ..e-ERERQFYLNLRERILVLFEGFQ................SPNNKNIEAKIDLTLNFLEYLLATIDEQLEK...
A0A292YDM6_9BACT/28-81 enc---DREFLKHLKERLLILFEGLQ................SPNTENLDVKLDVTLNFLEYLLVKIDEKLN-e..
A0A329ZKW2_9HELI/68-121 ..l-DDEISFLSLLEERLLVLFEGLN................QPQNSQDSKKLQMVLNFLQYQLSVIARRLE-i..
A0A099U2C7_9HELI/31-93 ..n-TGEIEFLQSFKERLFVLFEGLRqdel.......wsednADMQGKAESKLKLVLGFLQFQLALIDARLD-s..
D3UI53_HELM1/58-111 iri---DSRFLELLREKTLVLFEGLQ................SSQTKDIASKLDLVINYLEYQLSLIDETLQN...
V8CF67_9HELI/83-136 ..g-QDSIVYLENLREKLLVLFEGLK................MPELQDTQNKLDLVVRFLQYQLCVIDEILQK...
Q30RK4_SULDN/51-104 ..l-SNEMMFLTSMRERLLVLFEGFQ................APNNTNIEAKVDMTLNFLEYVLVTIDSRVEE...
A0A3D8IW90_9HELI/41-94 .li--DEKEFLSNQRKKLLVLFEGLL................SPETKEIEQKLELVLKYLQYSLSEIDKRLG-e..
A0A381DIH0_9BACT/60-113 ..n-TKEQIFLQNTKERILVLFEGLN................ENTKGDISLRLDLTIKFLEFLLASIENRLD-e..
CIAD_CAMJE/110-163 .tl--NEDIFLKHLRERILVLFEGLN................SIKKDDLENRLNLTINFLEFLLANIEDKLKK...
A0A329ZV33_9HELI/107-160 ..q-EDEQRFLEGLRERILVMFEGMQ................SPNNRVPEAKIDLILNFFEWQLAMIDERLE-r..
A0A6G5R3R1_9BACT/45-98 ..i-NGEEIFLKNLKERISVLFEGLN................AVSRENLEDRLELTLKFLEFVLANVENRLDN...
A0A091AP17_9BACT/53-106 ..r-EDEARWLEGIRERLLVLFEGFQ................SPNNAQIEAKVDLTLNFLEYLLATIDNRLDN...
A7I2S2_CAMHC/153-206 ..i-KDEIEFLTAIKERILVLFDGLE................MFDKADIEARVKLNLKFMEFLIASIENRIKN...
A0A3D8HXD8_9HELI/46-99 ..f-DDEIITLLRLKEKSLVLFEGLK................NTKDSTLEIKLEMVISYLEYQLYIIEDRLK-v..
A0A2P8R271_9BACT/49-102 ..n-NGEKEFLLSVKERILVLFEGLN................NFDKGDIEARVELNLKFMEFLLATIEDRLKK...
Q7VFR5_HELHP/63-116 ..l-REECEFLELLQERLLVLFEGLN................APQNKDIQSRLNITINFLEYQLSVIQERLN-d..
A0A1B8J748_9HELI/162-215 ..d-SKHIEFLENLREKLLVLFEGLK................MPELQDQQAKLDLVVNFLQYELCLLDEFLHK...
A7GXZ3_CAMC5/69-122 ..i-SSEEIFLKNLRERIEVLFEGLN................EMPKENLQSRLELTLKFLEFTLANVENRLEN...
A0A5P8P0L0_9BACT/55-108 ..s-MDEKAYLMSMRERLLVLFEGFQ................APNNTNIEAKIDLTLNYLEYVLASIDTRLEK...
S3YI90_9BACT/73-126 .il--SQEEFLLKIKERILVLFEGLN................SFDKGDIEARVELSLKFMEFLLANIDKRIS-d..
A0A2D3VR27_9BACT/58-111 ..a-DSEVKYLSSIRERLLVLFEGFQ................APNNANIEAKVDMTLNFLEYMLATIDSRVE-i..
A0A4V6DVT2_9BACT/87-140 .sf--NEEVFLKNIRERVLVLFEGLS................SSDEKDLRSRLDLTINFLEFLLANIEDKLKK...
F8KPA9_HELBC/45-98 ..s-QEEREFLKDLEQKTLVLFEGLK................SPQTKNLPAKLDLVVNYLQYQLYMVQERLKN...
C5ZYD9_9HELI/76-129 ..y-SEEEKFLNNLQDRILVLFEGLQ................SPNNRNIEEKVDMILNFLEFTLAIIDEKK--nq.
A0A268U2C7_9HELI/31-92 ..n-AGEAEFLHALKERLFVLFEGIKpdsd........eeelIEIQTNDKVKLNMICNFLQFQLALIDARLE-l..
A0A3G9H6W6_9BACT/66-119 .ea--GEREFLENLRERLLVLFEGFQ................SPNNRRVEAKIDLTLNFLEYLLALLDERID-t..
A0A1S6U7I3_9BACT/62-115 .lp--SEEIFLNNLKERIEVLFEGLN................ETSQQNLENRLELTLKFLEFTLANVENRLQN...
Q7MR14_WOLSU/72-125 ..r-EEERRFLEGLRERVLVLFEGMQ................SPNNRNIEAKVELTLNFFEYLLSVIDERLEK...
A0A7M1LEM3_9BACT/43-96 ..k-KGELEFLNSVKDRILVLFEGLS................NFDKGDIEARVELNLKFMEFLLATIDKRV--gd.
A0A6G5QH51_9BACT/62-115 ..v-TSEEIFLKNLKERIEVLFEGLN................EMPKERLEQRLDLTLKFLEFALANVENRLEN...
A0A2A2GTS5_9HELI/117-168 ..l-NDEKTFLKLLQDRLLVLFEGLS................MPQQD--PQKLTMVLNFLQYQLSVIAKRLEN...
A0A1X9SQP8_9BACT/122-175 ..g-SSEMLYLQGLKERIGVLFEGLN................SADSSNREFRMDMTIKFLEFMLASIDNRLSN...
A0A128EJV4_9BACT/144-197 ..k-EEQKEFLLSVQERILVLFEGLN................NFDKGDIEARVELNLKFMEFLLATIDNKLKN...
E0UT18_SULAO/50-103 ..m-DSELMYLNSIRERLLVLFEGFQ................APNNSNIEAKVDMTLNFLEYTLATIDARVEK...
A0A975B080_9BACT/56-109 ..v-DSELMYLNSIRERLLVLFEGFQ................APNNTNIEAKLDMTLNFLEYTLATIDLRVDK...
A0A222MY06_9BACT/89-142 .sf--NDEFFLKNIKERILVLFEGLK................ATKKENLEDRLDLTINFLEFLLANIEDRLKK...
A0A3D8IHC9_9HELI/55-108 ..v-NDEEELLLRLKEKSLVLFEGLR................ASQNKNVEMKLNMVIGYLEYQLYIIEDRLK-t..
A0A6L5WLE0_9BACT/62-115 .kn--AQKDFLINLKDRILVLFEGLN................SFDKSDIEARVELSLKFMEFLLASIEKKLKN...
A0A2W6MSK5_9HELI/75-128 ..y-QQEENFLNSLQERILVLFEGMQ................SPNNRNIEDKVDMILNFLEFVLAIIDEK---rnn
B6BJK2_SULGG/66-119 ..v-DGELLFLNSLRERLLVLFEGFQ................APNNTNIEAKVDMTLNFLEYSLATIDLRAE-q..
T1DW23_9HELI/113-166 ..d-PDNVEFVENLREKLLILFEGLQ................VAEIKDLEKKVSLVVNFLQYELCLLDEFLEK...
A0A4V6YSR6_9HELI/75-128 .yl--DEEKFLNALQERILVLFEGLQ................SPNNRNIENKVDMILNFLEFTLAIIDEKK--na.
I7HD87_9HELI/64-117 ..l-KEECEFLEGLQERLLVLFEGLK................AEHNQNIESALRITTHFLEHQLNVIQERLE-l..
A0A3D8HUP5_9HELI/112-164 ..l-SDEVQFLSLLQERLLVLFEGLN................QQNLQS-NKQLEMVINFLQYQLSVIERRLE-i..
E4U2R7_SULKY/64-117 ..r-DDEARMLEGIRERLLVLFEGFQ................SPNNTQIEAKVDLTLNFFEYLLATIDNRLE-t..
C3XI57_9HELI/31-93 ..n-TGETEFLQSFKERIFVLFEGLKqddl.......wlesaEDTQNQIQAKLDLILGFLQFQLALLDARLE-v..
A0A3D8IRL0_9HELI/31-92 ..n-TGEVEFLQSFKERIFVLFEGLKqddl........ftedESAKMQIEAKLDLILGFLQFQLALIDARLE-v..
A0A2D3W431_9BACT/64-117 ..l-SDERVFCENLRERVLVLFEGFQ................SPNNKNIEAKIDLTLNFLEYLLAIIDERLE-h..
#=GC seq_cons ..h.psEtpFLpsl+ERlLVLFEGLp................ussppslEsKlDLsLsFLEahLAhIDcRLc....
//
