GenomeNet

Database: Pfam
Entry: CoV_Methyltr_2
LinkDB: CoV_Methyltr_2
Original site: CoV_Methyltr_2 
#=GF ID   CoV_Methyltr_2
#=GF AC   PF06460.14
#=GF DE   Coronavirus 2'-O-methyltransferase
#=GF PI   NSP13; NSP16;
#=GF AU   Yeats C;0000-0003-0080-6242
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ADDA_12678
#=GF GA   20.10 20.10;
#=GF TC   20.30 20.30;
#=GF NC   19.90 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0063
#=GF RN   [1]
#=GF RM   21637813
#=GF RT   Crystal structure and functional analysis of the
#=GF RT   SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16
#=GF RT   complex.
#=GF RA   Decroly E, Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I,
#=GF RA   Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia
#=GF RA   M, Lescar J, Canard B;
#=GF RL   PLoS Pathog. 2011;7:e1002059.
#=GF RN   [2]
#=GF RM   22022266
#=GF RT   Biochemical and structural insights into the mechanisms of SARS
#=GF RT   coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein
#=GF RT   complex.
#=GF RA   Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z, Wu A, Sun Y, Yang Z,
#=GF RA   Tien P, Ahola T, Liang Y, Liu X, Guo D;
#=GF RL   PLoS Pathog. 2011;7:e1002294.
#=GF RN   [3]
#=GF RM   18417574
#=GF RT   Coronavirus nonstructural protein 16 is a cap-0 binding enzyme
#=GF RT   possessing (nucleoside-2'O)-methyltransferase activity.
#=GF RA   Decroly E, Imbert I, Coutard B, Bouvet M, Selisko B, Alvarez K,
#=GF RA   Gorbalenya AE, Snijder EJ, Canard B;
#=GF RL   J Virol. 2008;82:8071-8084.
#=GF DR   INTERPRO; IPR009461;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain covers the NSP16 region of the coronavirus
#=GF CC   polyprotein. The SARS-CoV RNA cap SAM-dependent
#=GF CC   (nucleoside-2'-O-)-methyltransferase (2'-O-MTase) is a
#=GF CC   heterodimer comprising SARS-CoV nsp10 and nsp16. When bound to
#=GF CC   nsp10, nsp16 is active as a type-0 RNA cap-dependent 2'-O-MTase,
#=GF CC   ie., active only when the cap guanine is methylated at its N7
#=GF CC   position. Nsp10 binds to nsp16 through an activation surface
#=GF CC   area in nsp10, and the resulting complex exhibits RNA cap
#=GF CC   (nucleoside-2'-O)-methyltransferase activity. Nsp10 is a double
#=GF CC   zinc finger protein together with nsp4, nsp5, nsp12, nsp14, and
#=GF CC   nsp16, nsp10 has been found to be essential in the assembly of a
#=GF CC   functional replication/transcription complex. Nsp16 adopts a
#=GF CC   typical fold of the S-adenosylmethionine-dependent
#=GF CC   methyltransferase (SAM) family as defined initially for the
#=GF CC   catechol O-MTase but it lacks several elements of the canonical
#=GF CC   MTase fold, such as helices B and C. The nsp16 topology matches
#=GF CC   those of dengue virus NS5 N-terminal domain and of vaccinia
#=GF CC   virus VP39 MTases [1, 2, 3].
#=GF SQ   81
#=GS A0A096XNJ3_9ALPC/6449-6748  AC A0A096XNJ3.2
#=GS R1AB_BC512/6493-6792        AC P0C6W0.1
#=GS A0A076PY83_9NIDO/7842-8060  AC A0A076PY83.1
#=GS H9BR07_9NIDO/5974-6250      AC H9BR07.1
#=GS R1AB_IBVB/6327-6629         AC P0C6Y1.1
#=GS A0A0U1UZ20_9ALPC/6597-6896  AC A0A0U1UZ20.1
#=GS A0A0U1UZC3_9ALPC/6363-6662  AC A0A0U1UZC3.1
#=GS R1AB_BCHK5/6876-7173        AC P0C6W4.1
#=GS R1AB_CVH22/6459-6758        AC P0C6X1.1
#=GS R1AB_BCHK4/6819-7116        AC P0C6W3.1
#=GS D9J202_9ALPC/6372-6670      AC D9J202.1
#=GS A0A0K1RM35_9ALPC/2381-2680  AC A0A0K1RM35.1
#=GS Q06BE0_9BETC/2345-2642      AC Q06BE0.1
#=GS R1AB_BC279/6783-7079        AC P0C6V9.1
#=GS H9BR24_9NIDO/5929-6203      AC H9BR24.1
#=GS V5TFR4_9GAMC/6363-6663      AC V5TFR4.1
#=GS A0A0K2RW65_9BETC/6820-7117  AC A0A0K2RW65.1
#=GS R1AB_CVM2/6827-7124         AC P0C6X8.1
#=GS R1AB_CVHOC/6798-7095        AC P0C6X6.1
#=GS B8Q8U6_SARS/6777-7073       AC B8Q8U6.1
#=GS A0A1X9JPE2_9ALPC/2370-2669  AC A0A1X9JPE2.1
#=GS A0A1B3Q5W8_9BETC/6682-6972  AC A0A1B3Q5W8.1
#=GS B7U2N0_9BETC/2420-2717      AC B7U2N0.1
#=GS B8Q8S4_SARS/6777-7073       AC B8Q8S4.1
#=GS R1AB_CVMA5/6879-7176        AC P0C6X9.1
#=GS K4K1U5_9ALPC/6480-6779      AC K4K1U5.1
#=GS A0A023YA54_MERS/6878-7175   AC A0A023YA54.1
#=GS A0A0U2LWJ9_9ALPC/2381-2680  AC A0A0U2LWJ9.1
#=GS A3EXC0_BCHK4/6829-7126      AC A3EXC0.1
#=GS Q0ZJB1_CVHK1/6884-7181      AC Q0ZJB1.1
#=GS A0A088DIE1_9BETC/6950-7247  AC A0A088DIE1.1
#=GS H9AA60_9BETC/6815-7112      AC H9AA60.1
#=GS T2B9U0_MERS/6777-7074       AC T2B9U0.1
#=GS A3EXA2_BCHK4/6819-7116      AC A3EXA2.1
#=GS Q6UZF5_SARS/6777-7073       AC Q6UZF5.1
#=GS R1AB_CVMJH/6883-7180        AC P0C6Y0.1
#=GS A0A0E3J9G4_9NIDO/2031-2234  AC A0A0E3J9G4.1
#=GS A0A0U1WHG4_9ALPC/6441-6740  AC A0A0U1WHG4.1
#=GS A3EXI9_BCHK9/6630-6924      AC A3EXI9.1
#=GS A0A0U1WHG1_9ALPC/6298-6591  AC A0A0U1WHG1.1
#=GS A0A0P0LKV0_CVH22/6464-6763  AC A0A0P0LKV0.1
#=GS B1PHJ3_9ALPC/6633-6932      AC B1PHJ3.1
#=GS A0A240FW17_9ALPC/6029-6324  AC A0A240FW17.1
#=GS H9BQZ9_9NIDO/5998-6275      AC H9BQZ9.1
#=GS R1AB_SARS2/6800-7096        AC P0DTD1.1
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WKQ A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WJT A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6W75 A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WRZ A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6W75 C; 6800-7095;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6W4H A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 7C2I A; 2-298;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WKQ C; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WJT C; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6W61 A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WVN A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 7BQ7 A; 2-297;
#=GS R1AB_SARS2/6800-7096        DR PDB; 7C2J A; 2-298;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6WQ3 A; 6800-7096;
#=GS R1AB_SARS2/6800-7096        DR PDB; 6XKM A; 2-298;
#=GS H9TEX0_9ALPC/6386-6685      AC H9TEX0.1
#=GS E0XIZ2_9BETC/6768-7064      AC E0XIZ2.1
#=GS A0A0U1UZ65_BCHK4/6827-7124  AC A0A0U1UZ65.1
#=GS H9BZX5_9BETC/6882-7179      AC H9BZX5.1
#=GS A0A0A7UXR0_9BETC/6841-7138  AC A0A0A7UXR0.1
#=GS F2YDB1_SARS/6777-7073       AC F2YDB1.1
#=GS A0A0U1UZA8_9ALPC/6632-6931  AC A0A0U1UZA8.1
#=GS R1AB_WBV24/6627-6814        AC Q008X6.1
#=GS R1AB_FIPV/6410-6709         AC Q98VG9.2
#=GS C0KYZ7_9BETC/2436-2733      AC C0KYZ7.1
#=GS A0A0U1WHK4_SARS/6777-7073   AC A0A0U1WHK4.1
#=GS H9BR34_9NIDO/5928-6205      AC H9BR34.1
#=GS R1AB_BCHK9/6635-6926        AC P0C6W5.1
#=GS A0A0K1YZY7_SARS/6777-7073   AC A0A0K1YZY7.1
#=GS B6VDX7_THCOV/6006-6284      AC B6VDX7.1
#=GS A0A140ESF0_9NIDO/5988-6265  AC A0A140ESF0.1
#=GS I6LMN0_9NIDO/6923-7141      AC I6LMN0.1
#=GS B1PHI6_9ALPC/6689-6988      AC B1PHI6.1
#=GS A0A125R5A3_9ALPC/6397-6696  AC A0A125R5A3.1
#=GS A0A0F6WGL5_9GAMC/6371-6672  AC A0A0F6WGL5.1
#=GS H9BR16_9NIDO/5999-6279      AC H9BR16.1
#=GS R1AB_SARS/6777-7073         AC P0C6X7.1
#=GS R1AB_SARS/6777-7073         DR PDB; 2XYR A; 3-292;
#=GS R1AB_SARS/6777-7073         DR PDB; 3R24 A; 3-294;
#=GS R1AB_SARS/6777-7073         DR PDB; 2XYQ A; 2-290;
#=GS R1AB_SARS/6777-7073         DR PDB; 2XYV A; 2-292;
#=GS E0ZN51_BCHK9/6630-6922      AC E0ZN51.1
#=GS A0A0U1WHD1_9ALPC/6590-6889  AC A0A0U1WHD1.1
#=GS U5KNA9_9BETC/6841-7138      AC U5KNA9.1
#=GS A8JNZ0_9ALPC/6428-6727      AC A8JNZ0.1
#=GS B1PHK0_9ALPC/6597-6896      AC B1PHK0.1
#=GS B2BW31_9GAMC/6363-6663      AC B2BW31.1
#=GS A0A0U1WHG0_SARS/6772-7068   AC A0A0U1WHG0.1
#=GS Q9J3E8_9BETC/2436-2733      AC Q9J3E8.1
#=GS Q0PL13_9ALPC/2381-2680      AC Q0PL13.1
#=GS R1AB_CVPPU/6385-6684        AC P0C6Y5.1
#=GS R9QTA1_SARS/2332-2628       AC R9QTA1.1
#=GS A3EXE7_BCHK5/6873-7170      AC A3EXE7.1
#=GS E0ZN59_BCHK9/6610-6903      AC E0ZN59.1
#=GS S5YAF0_9ALPC/6526-6825      AC S5YAF0.1
A0A096XNJ3_9ALPC/6449-6748             ..............................SSEWKCGYSMPPLYKIQSMILAPCSLYNYGKSIKLPEGIMFNV..VKYTQLCQYL.N.TT.SMCVPHKMRVLHLGAGS..DK.GVAPGT..AVLRNWLPEDAL.LVDNDLYDYVSDAD....ISYTGDCC......SMYL....DDKFDLVVSDMY....DGKTKQI.DGDNVSKDGFFVYINGVITERLSLGGTVAIKVTEFSWNRKLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGVNYLGNfCDKPIIDGCTMHANYIFWRNSTVMALSYNSVLDVNKFRLKCKATPVLSLKDGSFTPLVLTLIKNGKLIVRDTGVVVSFSNHLVN--lt......................
R1AB_BC512/6493-6792                   ..............................SAEWKCGYSMPSIYKIQRMCLEPCNLYNYGSGLKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCVPHHMRVLHLGAGS..DK.GVAPGT..AVLRRWLPLDAV.IVDNDVNDYVSDAD....FSYTGDCA......SMYL....TDKFDLVISDMY....DGRTKSC.DGDNVSKEGFFPYINGVITEKLALGGTVAIKITEFSWNKKLYELIQ.KFEY.WTLF.C.TSVNTSSSEAFLIGVHFLGDfSTNAIIDGNIMHANYIFWRNSTIMTMSYNSVLDLSKFSCKHKATVVVNLKDSSVTDLVLGLLKNGKLLIRNNGVVCGFSNHLVNS-t.......................
A0A076PY83_9NIDO/7842-8060             yqpviraydtatllnsniahfevmrnrldq---------------------------------------AVNI..TKYVQLCNYM.N.DN.IKISP-KATVLHLGAATgpEHdHIPVGG..VVLNHFFQ-NSD.VYHHDVRP------....---INDCN......GLFKvglpSKKVDLIISDIW....SYN-EDT.DGEWISNHELLI---NYVNAHLCLGGSIIWKTTRRSNLSYINYIAS.HFGQ.VDYV.T.TRGNASSSEMFVVFKYFKQQ.IQ------------------------------------------------------------------------------------qpqahnrdswqilhhlfayrh...
H9BR07_9NIDO/5974-6250                 ...........................qsl----TNGYQMPSVYKSLITDLQPADIPNYHAYTPKVPGIVKNV..IKYRQLFNYI.VkKD.RLAVPHNMTVLHLGAAS..AA.GTAPGS..SVIKQMLPEGTV.LIDLDIREFTSDAN....QIIVSDYR......TYMP....PHHVDAIFSDLY....CCD----.------DTHFFDNLVRIVKERLALGGSIFVKVTEHSFSPELYALAG.WFDE.YQFY.C.TAVNAASSEAFLCCFNYLGH.-AKENVDGYNLHASYIRWRNEIVLTPTYSPLADSPTVACKLKATPIISSKELEKKPILKYLVASGRLLVR----------------ppecg...................
R1AB_IBVB/6327-6629                    .............................q-SAWTCGYNMPELYKVQNCVMEPCNIPNYGVGITLPSGILMNV..AKYTQLCQYL.S.KT.TICVPHNMRVMHFGAGS..DK.GVAPGS..TVLKQWLPEGTL.LVDNDIVDYVSDAH....VSVLSDCN......KYNT....EHKFDLVISDMYtdndSKRKHEG.VIANNGNDDVFIYLSSFLRNNLALGGSFAVKVTETSWHEVLYDIAQ.DCAW.WTMF.C.TAVNASSSEAFLIGVNYLGA.SEKVKVSGKTLHANYIFWRNCNYLQTSAYSIFDVAKFDLRLKATPVVNLKTEQKTDLVFNLIKCGKLLVRDVGNTSFTSDSFVCT-m.......................
A0A0U1UZ20_9ALPC/6597-6896             ..............................SAEWKCGYSMPSLYKIQRMCLEPCNLYNYGASIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCVPHNMRVLHLGAGS..DK.GVAPGT..TVLRRWLPDDAV.IVDNDVNDYVSDAD....MSVVGDCT......TLYL....QDKFDLVISDMY....DGRIKHI.DGENVSKDGFFVYLNGVITEKLALGGSVAIKITEHSWNKRTYELIQ.KFAY.WTLF.C.TSVNTSSSEAFLIGVNYLGDlNTTPIVDGNVMHANYIFWRNSTIMAMSYNSVLDLSKFECRHKATVVIALKDTDLSEVIVGLIRNGKLLIRKNGSVCGYGNSLVST-k.......................
A0A0U1UZC3_9ALPC/6363-6662             ..............................SSEWKCGYSMPSLYKIQRMCLDTCNLYNYGAGLKLPDGIMFNT..LKYTQLCQYL.N.ST.TMCVPHNMRVLHLGAGS..DK.GVAPGT..CVLKRWLPLDAI.VVDNDINDYVSDAD....FSYTGDCN......TLFL....EDKFDLVISDMY....DGRTKLC.DGENVSKEGFFPYINGVILNKLSLGGTVAIKITEYSWNKRLYEIIQ.KFEF.WTLF.C.TSVNTSSSEAFLIGVNYLGDfCERPVTDGNTMHANYIFWRNSTIMTMSYNSVLDLSKFACKHKATVVVSLKDGDINSMVIGLVKSGKLLVRNNNKLCGFSNHLVST-k.......................
R1AB_BCHK5/6876-7173                   .............................i-NDWKPGLAMPSLFKVQNSNLEPCMLPNYKQSIPMPQGVHMNI..AKYMQLCQYL.N.TC.TIAVPANMRVMHFGAGS..DK.GVAPGS..SVLRQWLPTDAI.LIDNDLNEYVSDAD....ITLFGDCV......TVRV....GQQVDLLISDMY....DPSTKVV.GETNEAKALFFVYLCNFIKNNLALGGSVAIKITEHSWSAELYELMG.RFAW.WTVF.C.TNANASSSEGFLIGINYLGE.-LKEVIDGNVMHANYIFWRNTTLMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLIIRDNDTLSVSTDVLVN--fy......................
R1AB_CVH22/6459-6758                   ..............................SAEWKCGYSMPGIYKTQRMCLEPCNLYNYGAGLKLPSGIMFNV..VKYTQLCQYF.N.ST.TLCVPHNMRVLHLGAGS..DY.GVAPGT..AVLKRWLPHDAI.VVDNDVVDYVSDAD....FSVTGDCA......TVYL....EDKFDLLISDMY....DGRTKAI.DGENVSKEGFFTYINGFICEKLAIGGSIAIKVTEYSWNKKLYELVQ.RFSF.WTMF.C.TSVNTSSSEAFVVGINYLGDfAQGPFIDGNIIHANYVFWRNSTVMSLSYNSVLDLSKFNCKHKATVVVQLKDSDINEMVLSLVRSGKLLVRGNGKCLSFSNHLVST-k.......................
R1AB_BCHK4/6819-7116                   .............................t-NDWKPGLTMPSLFKVQQMNLEPCLLANYKQSIPMPNGVHMNV..AKYMQLCQYL.N.TC.TLAVPANMRVIHFGAGC..EK.GVAPGT..SVLRQWLPLDAV.LIDNDLNEFVSDAD....ITIFGDCV......TVHV....GQQVDLLISDMY....DPCTKAV.GEVNQTKALFFVYLCNFIKNNLALGGSVAIKITEHSWSADLYKIMG.RFAY.WTVF.C.TNANASSSEGFLIGINFLGE.-LKEEIDGNVMHANYIFWRNSTPMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLNVSTDVLVN--fr......................
D9J202_9ALPC/6372-6670                 ..............................SAEWKPGYSMPNLYKIQRMCLERCNLYNYGASLQLPDGITTNV..IKYTQLCQYL.N.TT.SICVPHKMRVLHLGASS..HD.GVAPGT..SVLRRWLPDDAI.LVDNDVRDYTSDAD....FSITGDCT......SMYL....EDKFDLLISDMY....DSTNKSI.DCNNISKEGFFPYINGFIREKLSLGGSVAIKLTEYSWNKELYELIQ.RFEY.WTMF.C.TSVNTSSSEAFLIGVNYMGDySEKYIIDGNVMHANYIFWRNSTVMSLSYYSVFDLTKFKCKFNNALVVNLKDSDINVMVKGLIKGGKLLVRNNGKLLNFGNHLVN--a.......................
A0A0K1RM35_9ALPC/2381-2680             ..............................SSEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNV..VKYTQLCQYL.N.TT.TLCVPHKMRVLHLGAAG..AS.GVAPGS..TVLRRWLPDDAI.LVDNDLRDYVSDAD....FSVTGDCT......SLYI....EDKFDLLVSDLY....DGSTKSI.DGENTSKDGFFTYINGFIREKLSLGGSVAIKVTEFSWNKDLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGISYLGPyCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFVNT-t.......................
Q06BE0_9BETC/2345-2642                 .............................a-SDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNV..AKYTQLCQYL.N.TT.TLAVPVNMRVLHLGAGS..EK.GVAPGS..AVLRQWLPAGTI.LVDNDLYPFVSDSV....ATYFGDCI......TLPF....DCQWDLIISDMY....DPITKNI.GEYNVSKDGFFTYICHMIRDKLALGGSVAIKITEFSWNAELYKLMG.YFAF.WTVF.C.TNANASSSEGFLIGINYLGK.-PKVEIDGNVMHANYLFWRNSTVWNGGAYSLFDMAKFPLKLAGTAVINLRADQINDMVYSLLEKGKLLVRDTNKEVFVGDSLVNV-i.......................
R1AB_BC279/6783-7079                   ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGAL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPKTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSVAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGVNYLGK.-LREQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLENGRLIIRENNRVVVSSDILVN--n.......................
H9BR24_9NIDO/5929-6203                 ..........................qslv-----NGYQMPSIYKTLTCDRSVCDIANYHVWKPSIPGVYKNV..LKYRQLLAYIiK.KD.RLAVPHNMTVLHLGAAS..AE.GVAPGT..SVLRQYFPEGTR.IIDVDLREFVSDAN....QCIVKDYR......TFMP....PEYVDCIFSDMY....ST-----.------EVGFFDNLVHIVTKTLALGGSLFVKMTEHSYSQQLYDLAG.TFEQ.YELF.C.TGVNATSSEVWLCCFNYLSR.--LRHIVPSDMHANYIKWRNENPLKPVYSTLADSVYNVVKLKATPVIGFNEINSKPILYTLVATGRLLVR----------------ppctg...................
V5TFR4_9GAMC/6363-6663                 ............................ps--VWSPGFNMPELYKVQNCQLEKCELANYGKTVLLPPGILMNV..AKYTQLCQYL.S.KT.TMCVPHNMRVMHFGAGS..DK.GVAPGT..SVLRQWLPEGAL.LIDNDINRYVSDAD....ACVISDCN......VFKS....QGKFDLIISDMYtspkGVDIHEG.IIKNNGISDCFGYLCHFIKNNLSLGGTFAVKITETSWLPELYELAQ.KCAY.WTCF.C.TAVNTSSSEAFLVGVNYLGD.VEKPIIDGSVMHANYLFWRNVTDLPLSARSLFDIAKFGLKVKATPVVNLKKENITELVINLLKNGKIVIRDSASVHYVDDSLI---i.......................
A0A0K2RW65_9BETC/6820-7117             .............................a-SDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNV..AKYTQLCQYL.N.TT.TLAVPVNMRVLHLGAGS..EK.GVAPGS..AVLRQWLPAGTI.LVDNDLHPFVSDSV....ASYFGDCI......TLPF....DCQWDLIISDMY....DPITKNI.GEYNVSKDGFFTYICHMIRDNLALGGSVAIKITEFSWNAELYKLMG.CFAF.WTVF.C.TNANASSSEGFLIGINYLGK.-SKFDIDGNVMHANYLFWRNSTVWNGGSYSLFDMAKFPLKLAGTAVINLRADQINDMVYSLLEKGKLLIRDTSKEVFVGDSLVNV-i.......................
R1AB_CVM2/6827-7124                    ..............................AADWKPGYVMPVLYKYLESPLERVNLWNYGKPITLPTGCLMNV..AKYTQLCQYL.N.TT.TLAVPANMRVLHLGAGS..DK.DVAPGS..AVLRQWLPAGSI.LVDNDINPFVSDSV....ASYYGNCI......TLPI....ACQWDLIISDMY....DPLTKNI.GEYNVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTIF.C.TNVNASSSEGFLIGINWLNR.-TRTEIDGKTMHANYLFWRNSTMWNGGAYSLFDMSKFPLKVAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDSLVNV-k.......................
R1AB_CVHOC/6798-7095                   .............................a-SDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNV..AKYTQLCQYL.N.TT.TLAVPVNMRVLHLGAGS..EK.GVAPGS..AVLRQWLPAGTI.LVDNDLYPFVSDSV....ATYFGDCI......TLPF....DCQWDLIISDMY....DPITKNI.GEYNVSKDGFFTYICHMIRDKLALGGSVAIKITEFSWNAELYKLMG.YFAF.WTVF.C.TNANASSSEGFLIGINYLCK.-PKVEIDGNVMHANYLFWRNSTVWNGGAYSLFDMAKFPLKLAGTAVINLRADQINDMVYSLLEKGKLLIRDTNKEVFVGDSLVNV-i.......................
B8Q8U6_SARS/6777-7073                  ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPRTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVN--n.......................
A0A1X9JPE2_9ALPC/2370-2669             .............................n-SEWKCGYSMPPLYKIQSMVLAPCSLYNYGKSIKLPDGIMFNV..VKYTQLCQYL.N.TT.SMCVPHKMRVLHLGAGS..DK.GVAPGT..AVLKNWLPDDAV.LVDNDLYDYVSDAD....ISYTGDCC......SMYL....EDKFDLVISDMY....DGKTKQI.DGDNVSKEGFFVYINGVISEKLSLGGTVAIKITEFSWNRKLYELIQ.KFEY.WTVF.C.TSVNTSSSEGFLIGVNYLGNfSDRPIIDGCTMHANYIFWRNSTVMALSYNSVLDVNKFRLKTKATPVLFLKEGSFTPLVLTLIKNGKLIVRDTGVVVNFTNHLVN--hf......................
A0A1B3Q5W8_9BETC/6682-6972             .............................k-QDWKPGYSMPALYKVQNAVLEPCLLHNYGQPARLPYGTLMNV..AKYTQLCQYL.N.TC.TLSVPAKMRVMHFGAGS..DK.GVCPGT..SVLKQWLPTDAL.LVDNDLDRCVSDAN....YTFVGNCE......LFST....NHKWDLVISDMY....DARTKQV.NGDNISKEGFFTYLTGFIKSKLALGGSIAVKITEHSWNADLYAMMG.HFGW.WTCF.C.TSVNSSSSEAFLIGINYLGR.--GQLLDGDQLHANYVFWRNSTLMQLSSYSLYDLQRFSLRAKGTPVMTLNESQLNELVLNLLKAGRLLIRDVSDVA----------lsgv....................
B7U2N0_9BETC/2420-2717                 .............................a-SDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNV..AKYTQLCQYL.N.TT.TLAVPVNMRVLHLGAGS..EK.GVAPGS..AVLRQWLPAGTI.LVDNDLYPFVSDSV....ATYFGDCI......TLPF....DCQWDLIISDMY....DPITKNI.GEYNVSKDGFFTYICHMIRDKLALGGSVAIKITEFSWNAELYKLMG.YFAF.WTVF.C.TNANASSSEGFLIGINYLGK.-PKVEIDGNVMHANYLFWRNSTVWNGGAYSLFDMAKFPLKLAGTAVINLRADQINDMVYSLLEKGKLLVRDTNKEVFVGDSLVNV-i.......................
B8Q8S4_SARS/6777-7073                  ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPRTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVN--n.......................
R1AB_CVMA5/6879-7176                   ..............................AADWKPGYVMPVLYKYLESPLERVNLWNYGKPITLPTGCMMNV..AKYTQLCQYL.S.TT.TLAVPANMRVLHLGAGS..DK.GVAPGS..AVLRQWLPAGSI.LVDNDVNPFVSDSV....ASYYGNCI......TLPF....DCQWDLIISDMY....DPLTKNI.GEYNVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTIF.C.TNVNASSSEGFLIGINWLNK.-TRTEIDGKTMHANYLFWRNSTMWNGGAYSLFDMSKFPLKAAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDSLVNV-k.......................
K4K1U5_9ALPC/6480-6779                 ..............................SAEWKCGYSMPSIYKIQRMCLEPCNLYNYGASIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCVPYNMRVLHLGAGS..DK.GVAPGT..AVLRRWLPSDAI.IVDNDVEDYVSDAD....YSITGDCS......TVYL....EDKFDLVISDMY....DGKTKHC.DGENVSKEGFFVYINGVINEKLALGASVAIKVTEYSWNKKLYELIQ.RFEF.WTLF.C.TSVNTSSSEAFLIGINYLGTfSDKPVIDGNVVHANYIFWRNSTIMSMSYNSVLDLAKFNCKHRATAVIQLKDSDINDMVLGLIKRGKILIRMNGTYMGFSNHLVST-k.......................
A0A023YA54_MERS/6878-7175              ..............................SNDWKPGLAMPSLFKVQNVNLEPCQLANYKQSIPMPRGVHMNV..AKYMQLCQYL.N.TC.SIAVPANMRVMHFGAGS..DK.GIAPGT..SVLRQWLPVDAL.LIDNDLNEYVSDAD....ISLFGDCV......TVRV....GQQVDLVISDMY....DPITKNV.KGTNEAKALFFTYLCNFINNNLALGGTVAIKITEHSWSADLYELMG.KFAW.WTVF.C.TNANASSSEGFLIGVNYLGT.-IREVVDGNAMHANYIFWRNSTPMNLSTYSLFDLSKFSIKLKGTPVLQLKEGQINELVISLLSQGKLLIRDNDPLNVSTDVLVNT-y.......................
A0A0U2LWJ9_9ALPC/2381-2680             ..............................SAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNV..VKYTQLCQYL.N.TT.TLCVPHKMRVLHLGAAG..AA.GVAPGS..TVLRRWLPDDAI.LVDNDLRDYVSDAD....FSVTGDCT......SLYI....EDKFDLLISDLY....DGSTKSI.DGENTSKDGFFTYINGFIKEKLSLGGSVAIKITEFSWNKDLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGINYLGPyCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFVNT-p.......................
A3EXC0_BCHK4/6829-7126                 .............................t-NDWKPGLTMPSLFKVQQMNLEPCLLANYKQSIPMPNGVHMNV..AKYMQLCQYL.N.TC.TLAVPANMRVIHFGAGC..EK.GVAPGT..SVLRQWLPLDAV.LIDNDLNEFVSDAD....ITIFGDCV......TVHV....GQQVDLLISDMY....DPCTKAV.GEVNQTKALFFVYLCNFIKNNLALGGSVAIKITEHSWSADLYKIMG.RFAY.WTVF.C.TNANASSSEGFLIGINFLGE.-LKEEIDGNVMHANYIFWRNSTPMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLNVSTDVLVN--fr......................
Q0ZJB1_CVHK1/6884-7181                 .............................t-SDWKPGYSMPVLYKYLNVPLERVSLWNYGKAINLPIGCMMNV..AKYTQLCQYL.N.TT.TLAVPVNMRVLHLGAGS..DK.EVAPGS..AVLRQWLPSGSI.LVDNDLNPFVSDSL....VTYFGDCM......TLPF....DCHWDLIISDMY....DPLTKNI.GDYNVSKDGFFTYICYLIRDKLSLGGSVAIKITEFSWNADLYKLMS.YFAF.WTVF.C.TNVNASSSEGFLIGINYLGK.-SCFEIDGNVMHANYLFWRNSTTWNGGAYSLFDMSKFSLKLAGTAVVNLRPDQLNDLVYSLIERGKLLVRDTRKEIFVGDSLVNT-c.......................
A0A088DIE1_9BETC/6950-7247             ..............................SSEWQPGQSMPRLYKIQTMCMEKCELLNYGQPPKLPNGILMNV..AKYTQLCQYL.N.KT.TIAVPAKMRVIHFGAGS..EK.GIAPGS..TVLKQWLPKDAI.LVDNDLNDFASDAD....VTIIGNCV......TFHT....ETKWDLLVSDMY....DCDFKSTtMGENYSKDSFFPYLCGFIKNKLSIGGSVAIKITEHSWSADLYNLMG.HFAW.WTAF.C.TNVNASSSEAYLIGVNYVGK.-EVEKIDGNIMHANYIFWRNYSPFNVSNYSLFDMSKFALKAKGTPVMSLKKEQINEMVLGLVEKGRLLIRDTNSFVLTNDMMVN--c.......................
H9AA60_9BETC/6815-7112                 .............................a-SDWKPGYSMPVLYKYLTSPMERVNLWNYGKPITLPTGCMMNV..AKYTQLCQYL.N.TT.TLAVPVNMRVLHLGAGS..EK.GVAPGS..AVLRQWLPAGTI.LIDNDLYPFVSDSV....ATYFGDCI......TLPF....ECQWDLIISDMY....DPITKNI.GEYNVSKDGFFTYICHMIRDKLALGGSVAIKITEFSWNAELYKLMG.YFAF.WTVF.C.TNANASSSEGFLIGINYLGK.-PKVDIDGNVMHANYLFWRNSTVWNGGAYSLFDMAKFPLKLAGTAVINLKPDQINDMVYSLLEKGKLLIRDTNKEVFVGDSLVNV-i.......................
T2B9U0_MERS/6777-7074                  ..............................SADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNI..AKYMQLCQYL.N.TC.TLAVPANMRVIHFGAGS..DK.GIAPGT..SVLRQWLPTDAI.IIDNDLNEFVSDAD....ITLFGDCV......TVRV....GQQVDLVISDMY....DPTTKNV.TGSNESKALFFTYLCNLINNNLALGGSVAIKITEHSWSVELYELMG.KFAW.WTVF.C.TNANASSSEGFLLGINYLGT.-IKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDVLVNT-y.......................
A3EXA2_BCHK4/6819-7116                 .............................t-NDWKPGLTMPSLFKVQQMNLEPCLLANYKQSIPMPNGVHMNV..AKYMQLCQYL.N.TC.TLAVPANMRVIHFGAGC..EK.GVAPGT..SVLRQWLPLDAV.LIDNDLNEFVSDAD....ITIFGDCV......TVHV....GQQVDLLISDMY....DPCTKAV.GEVNQTKALFFVYLCNFIKNNLALGGSVAIKITEHSWSADLYKIMG.RFAY.WTVF.C.TNANASSSEGFLIGINFLGE.-LKEEIDGNVMHANYIFWRNSTPMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLNVSTDVLVN--fr......................
Q6UZF5_SARS/6777-7073                  ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPRTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVN--n.......................
R1AB_CVMJH/6883-7180                   ..............................AADWKPGYVMPVLYKYLESPMERVNLWNYGKPITLPTGCMMNV..AKYTQLCQYL.S.TT.TLAVPANMRVLHLGAGS..DK.GVAPGS..AVLRQWLPSGSI.LVDNDMNPFVSDSV....ASYYGNCI......TLPF....DCQWDLIISDMY....DPLTKNI.GEYNVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTIF.C.TNVNASSSEGFLIGINWLNR.-TRNEIDGKTMHANYLFWRNSTMWNGGAYSLFDMTKFPLKAAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDSLVNV-k.......................
A0A0E3J9G4_9NIDO/2031-2234             ....................yiiwpkifsd------------------SPVDKWDIPNYNQP---PKGLTSNVniHKYDQMCAFF.D.K-.HLTIPTNGHVHHLGHAG..Q-.VYSPGD..IVLKGYFTK-AR.LTSYDLRDCISTSE....TAHPDDNW......R---....---AHFILSDAY....CPNT---.--------DFTSLCKDYMTKHLRLGGSMLWKMTETC-NIDAESILP.YFGS.FTFV.T.FAVNYSSSETYAFLKGYMGEpNYNTTLPA------------------------------------------------------------------------------nimgqlgayrqn............
A0A0U1WHG4_9ALPC/6441-6740             ..............................SAEWKCGYSMPSLYKIQRMCLEPCNLYNYGTGLKLPDGIMFNV..VKYTQLCQYL.N.ST.SMCVPHNMRVLHLGAGS..DK.GVAPGT..AVLKRWLPSDAI.VVDNDVNDYVSDAD....YSVTGDCS......TVYL....EDKFDLVISDMY....DGRVKQN.DGENVSKEGFFTYINGVINEKIALGATVAIKVTEYSWNKRLYELIQ.RFEF.WTLF.C.TSVNTSSSEAFLIGVNYLGNfANNPILDGNTMHANYIFWRNSTIMSMSYNSVLDLAKFNCRHKATVIVSLKDKDINDVVLGLIRNGKLLIRNNGIYMGFSNHLVST-k.......................
A3EXI9_BCHK9/6630-6924                 .............................k-QDWKPGYSMPALYRVQNAVLEPCLLHNYGQAARLPSGTLMNV..AKYTQLCQYL.N.TC.TLAVPAKMRVIHFGAGS..DK.GVCPGT..SVLKQWLPTDAI.LVDNDIDRCASDAN....STFVGNCE......LFNT....ANKWDFVFSDMY....DARTKII.DGENISKDGFFTYLVGFIRDKLALGGSVAIKITEHSWSADLYSMMG.LFSW.WTCF.C.TAANSSSSEAFIIGVNYLGE.--GNLLNGEQMHANYIFWRNSTIMQLSSYSLYDMQKFNLRSKGTPVMNLRKDQLNELVLNLVRTGRLIIRDVADSIHI--------atsgns..................
A0A0U1WHG1_9ALPC/6298-6591             ..............................SAEWKCGYSMPTLYKIQRMCLEPCNLYNYGEGVRLPEGIMFNV..VKYTQLCQYL.N.ST.TMCVPHNMRVLHLGAGS..DK.GVAPGT..AVLRRWLPSDAV.ILDNDVNTYVSDAD....FSHTGDCS......TLYL....TDKFDLVISDMY....DGRIKAI.DGANVSKDGFFTYINGVICEKLALGGTAAIKITEYSWNRKLYELMQ.KFAY.WTLF.C.TSVNTSSSEAFLIGVNYLGDfSETPVIDGATCHANYIFWRNSTLMAMSYNSVLDLTRFECKHKATVVVNLKESDVNEVVLGLVKSGKLLIRNTGVV-----------cgyaq...................
A0A0P0LKV0_CVH22/6464-6763             ..............................SAEWKCGYSMPSIYKTQRMCLEPCNLYNYGAGLKLPSGIMFNV..VKYTQLCQYL.N.ST.TLCVPHNMRVLHLGAGS..DH.GVAPGT..AVLKRWLPQDAI.VVDNDVVDYVSDAD....FSITGDCA......TVYL....EDKFDLVVSDMY....DGRTKSI.DGENVSKEGFFTYINGVICEKLAIGGSIAVKVTEYSWNKRLYELAQ.KFAF.WTMF.C.TSVNTSSSEAFVIGINYLGDlAQGPFIDGNVVHANYVFWRNSTIMSLSYNSVLDLSRFNCKHKATVVVQLKESEINEMVLSLVKSGRLLVRGNNKCVGFSNHLVST-k.......................
B1PHJ3_9ALPC/6633-6932                 ..............................SAEWKCGYSMPSLYKVQRMCLEPCNLYNYGASIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCIPHSMRVLHLGAGS..DK.GVAPGT..SVLRRWLPTDAV.IVDNDVNDYVSDAD....ISVTGDCT......TLYL....QDKFDLVISDMY....DGRIKQM.DGENVSKDGFFVYINGVITEKLALGGTVAIKITEYSWNKRLYELIQ.KFSY.WTMF.C.TSVNTSSSEASLIGVNYLGDfATDPIIDGNVLHANYIFWRNSTVMAMSYNSVLDLAKFQCRHKATVVIALKDNDISDVILGLIKNGKLFIRKNGVVCSYGNHLVST-k.......................
A0A240FW17_9ALPC/6029-6324             .............................q-NDWLCGYSMPNVYKMQNMLLERCDLPNYGERLNLPGQIVKNT..IKYTQLCQYL.N.KT.TICVPYNMRVVHFGAS-..GN.GVSPGT..AVLKRWLPQSAI.LLDNDCRNFASDAD....YTIIGSCE......VVKI....STKVDLIISDMY....DCEKVRS.LEENKGEDGFFRFLVGFIREKLSVGGTVCIKITEFSWNKELYEEIQ.KFEF.WTLF.C.TSVNASSSEAFLIGVNYLGNfSNKDIIKGDVCHANYIFWRNSTIMKQSYNSVLDLSKFELKLKTTTVVDLKDDKVNDLVLGLIKSGKLIIRDCGKQDFYANKFV---........................
H9BQZ9_9NIDO/5998-6275                 ...........................qsl----TNGYQMPSVYKTLITDLQPADIPNYHSYTPRVPGVVKNV..IKYRQLFNYI.VkKD.RMAVPHNMTVLHLGAAS..AL.GTAPGS..SVIKQMFPEGTV.LIDLDIREFTSDAN....QIIVTDYR......TYMP....PHHVDAIFSDLY....CCDD---.-------IHFFDNLIRIVKERLALGGSIFVKITEHSYSPELYALAG.WFDD.YQLF.C.TAVNASSSEAFLCCFNYLGH.-AKENVNGFNLHASYIQWRNEIALTPTYSPLADNPATACKLKATPIISARELEKKPILRYLVASGRLLVRP---------------pecre...................
R1AB_SARS2/6800-7096                   ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPKTKNV.TKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMG.HFAW.WTAF.V.TNVNASSSEAFLIGCNYLGK.-PREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVN--n.......................
#=GR R1AB_SARS2/6800-7096        SS    ..............................GGGGSSEEE--HHHHT----------TTTT-----STT--HHH..HHHHHHHHHH.T.TS.----BTT-EEEEES---..TT.SB-HHH..HHHHHHS-TT-E.EEEEESS--B-SSS....EEEES-GG......GEEE....SS-EEEEEE---....-GGGHHT.TS------THHHHHHHHHHHHEEEEEEEEEEE-SSS--HHHHHHHT.TEEE.EEEE.E.EGGGTTSS-EEEEEEEE-SS.--SS---HHHHHHHHHHHHHHS------GGGG--TT-S-----BEEE---GGG--HHHHHHHHTT-EEES--S--EEEE-EE-----.......................
H9TEX0_9ALPC/6386-6685                 ..............................SAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVRLPDGITTNV..VKYTQLCQYL.N.TT.TVCVPHKMRVLHLGAAG..AS.GVAPGS..TVLRRWLPDDAI.LVDNDLRDYVSDAD....FSVTGDCT......SLYI....EDKFDLLISDLY....DGSTKSI.DGENTSKDGFFTYINGFIKEKLSLGGSAAIKITEFSWNKDLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGINYLGPyCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVVGLLRKGKLLIRNNGKLLNFGNHLVNV-p.......................
E0XIZ2_9BETC/6768-7064                 .............................n-QTWQPGVAMPNLYKMQRMLLDKCDLHNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TIAVPYNMRVIHFGAGS..DK.GVAPGS..AVLKQWLPVGTL.LVDSDINDFVSDAD....STLIGDCS......TVYT....ANKWDLIISDMY....DPKTKHI.LKENDSKEGFFTYLCGFIKQKLALGGSVAIKITEHSWNADLYKLMG.YFSW.WTAF.V.TNVNASSSEAFLIGVNYLGK.-QKESIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKDNQINDMICSLLEKGRLIIRENNKVVFSSDVLVN--n.......................
A0A0U1UZ65_BCHK4/6827-7124             .............................a-NDWKPGLTMPSLFKVQQMNLEPCLLANYKQSIPMPNGVHMNV..AKYMQLCQYL.N.TC.TLAVPANMRVIHFGAGC..EK.GVAPGT..SVLRQWLPLDAV.LIDNDLNEFVSDAD....ITIFGDCV......TVHV....GQQVDLLISDMY....DSCTKAV.GEVNQTKALFFVYLCNFIKNNLALGGSVAIKITEHSWSADLYKIMG.RFAY.WTVF.C.TNANASSSEGFLIGINFLGE.-LKEEIDGNVMHANYIFWRNSTPMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLNVSTDVLVN--fr......................
H9BZX5_9BETC/6882-7179                 ..............................AADWKPGYVMPVLYKYLESPLERVNLWNYGKPITLPTGCMMNV..AKYTQLCQYL.S.TT.TLAVPANMRVLHLGAGS..DK.GVAPGS..AVLRQWLPAGSI.LVDNDMNPFVSDSV....ASYYGSCI......TLPF....DCQWDLIISDMY....DPLTKNI.GEYNVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTIF.C.TNVNASSSEGFLIGINWLNK.-TRTEIDGKTMHANYLFWRNSTMWNGGAYSLFDMTKFPLKAAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDSLVNV-k.......................
A0A0A7UXR0_9BETC/6841-7138             .............................a-SDWKPGYTMPVLYKYLNSSMERVDLWNYGKVIPLPTGCMMNV..AKYTQLCQYL.N.TT.TLAVPANMRVLHLGAGS..DK.GVAPGS..AVLRQWLPAGTI.LIDNDLNPFVSDSV....ATYFGDCV......TLPF....DCQWDLIISDMY....DPITKNI.GEYNVSKDGFFTYICHLIRSKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTVF.C.ANANASSSEGFLVGINYLGK.-SKVEIDGNVMHANYLFWRNSQMWNGGSYSLFDMTKFPLKLAGTAVVNLKADQINDMVYSLIEKGKLLVRDTNKECFTGDSLVNV-s.......................
F2YDB1_SARS/6777-7073                  ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPRTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVN--n.......................
A0A0U1UZA8_9ALPC/6632-6931             ..............................SAEWKCGYSMPSLYKVQRMCLEPCNLYNYGASIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCIPHSMRVLHLGAGS..DK.GVAPGT..SVLRRWLPTDAV.IVDNDVNDYVSDAD....ISVTGDCT......TLYL....QDKFDLVISDMY....DGRIKQM.DGENVSKDGFFVYINGVITEKLALGGTVAIKITEYSWNKRLYELIQ.KFSY.WTMF.C.TSVNTSSSEAFLIGVNYLGDfATDPIIDGNVLHANYIFWRNSTVMAMSYNSVLDLAKFQCRHKATVVIALKDNDISDVILGLIKNGKLLIRKNGVVCSYGNHLVST-k.......................
R1AB_WBV24/6627-6814                   ....................tneatdcwai--------------------------PNYNAPPK-NQTCNINI..QKYDQMCDLF.-.AI.DLKIPVKGHIHHLGNAG..NK.-YSPGD..VVLRQYFD-QAH.LTSYDLREVVSDIP....VLHPND--......----....EWKAHFILSDVY....APDT---.--------DFTSLALEYMQNHLRLGGSIMWKMTETSIL-QVNEIVK.YFGS.WKAV.T.FAVNYSSSETFLFCAGYTGV.EY------------------------------------------------------------------------------------ntsivqngyms.............
R1AB_FIPV/6410-6709                    ..............................SAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVRLPDGITTNV..VKYTQLCQYL.N.TT.TVCVPHKMRVLHLGAAG..AS.GVAPGS..TVLRRWLPDDAI.LVDNDLRDYVSDAD....FSVTGDCT......SLYI....EDKFDLLISDLY....DGSTKSI.DGENTSKDGFFTYINGFIKEKLSLGGSAAIKITEFSWNKDLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGINYLGPyCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVVGLLRKGKLLIRNNGKLLNFGNHLVNV-p.......................
C0KYZ7_9BETC/2436-2733                 ..............................AADWKPGYVMPVLYKYLESPMERVNLWNYGKPITLPTGCMMNV..AKYTQLCQYL.S.TT.TLAVPANMRVLHLGAGS..DK.GVAPGS..AVLRQWLPSGSI.LVDNDMNPFVSDSV....ASYYGNCI......TLPF....DCQWDLIISDMY....DPLTKNI.GEYNVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTIF.C.TNVNASSSEGFLIGINWLNR.-TRNEIDGKTMHANYLFWRNSTMWNGGAYSLFDMTKFPLKAAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDSLVNV-k.......................
A0A0U1WHK4_SARS/6777-7073              ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPKTKHV.TRENDSKEGFFTYLCGFIKQKLALGGSVAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVLPSDILVN--n.......................
H9BR34_9NIDO/5928-6205                 ...........................vqs---LTNGYQMPSVYKSLVTELEPCDIPNYHAYIPKVPGVIKNV..IKYRQLFNYI.VkKD.RLAVPHNMTVLHLGAAS..FD.GVAPGS..AVIKQMFPEGTV.LIDLDIRDFVSDAN....QVIVTDYR......TYMP....PHYVDAIFSDLY....CND----.------DIHFFDNLIRIVHERLALGGSIFVKVTEHSYSAALYELAG.YFDE.YQLF.C.TAVNASSSEAFLCCFNYLGY.-AKYNIDGYNAHAAYIKWRNEIVLTPTYSPLADITTTIVKLKATPVVSKKELDKKPILNYLVASGRLLVR----------------ppecs...................
R1AB_BCHK9/6635-6926                   .............................k-QDWKPGYSMPALYKVQNAVLEPCLLHNYGQAARLPSGTLMNV..AKYTQLCQYL.N.TC.SLAVPAKMRVMHFGAGS..DK.GVCPGT..AVLKQWLPADAY.LVDNDLCYCASDAD....STYVGSCE......TFFS....VNKWDFIFSDMY....DARTKNT.SGDNTSKEGFFTYLTGFIRSKLALGGSIAIKITEHSWSADLYAIMG.HFNW.WTCF.C.TSVNSSSSEAFLIGVNYIGV.--GALLDGWQMHANYVFWRNSTVMQLSSYSLYDLQRFPLRLKGTPVMSLKEDQLNELVLNLIRAGRLIVRDAV-------------digvrgva................
A0A0K1YZY7_SARS/6777-7073              ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPKTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSAAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGVNYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMFLKENQINDMIYSLLEKGRLIIRENNTVVVSSDVLVN--h.......................
B6VDX7_THCOV/6006-6284                 ...........................vqs---LTNGYQMPSVYKTLVCDLEPCDIPNYHAYVPRVPGVVKNV..LKYRQLFNYIiK.KD.RLAVPHNMTVLHLGAAS..IE.GTAPGT..DVIKHMLPEGTV.IIDLDIREFTSDAN....QIIISDYR......TYMP....PHHIDAIFSDMY....CGDD---.-------IHFFDNLIRIVKERLALGGSLFVKITEHSYSPELYALAG.HFDD.YQLF.C.TAVNASSSESFLCCFNYLGS.-VKENVNGHMLHAAYIRWRNEIALTPTYSPLADNAAVVCKLKATPIISAKELEKKPILKYLVASGRLLVRP---------------pecre...................
A0A140ESF0_9NIDO/5988-6265             ...........................qsl----TNGYQMPSVYKTLVTDLQPADIPNYHSYTPRVPGVVKNV..IKYRQLFNYI.VkKD.RLAVPHNMTVLHLGAAS..AL.GTAPGS..SVIKQMFPEGTV.LIDLDIREFTSDAN....QIIVTDYR......TYIP....PHHVDVIFSDLY....CCDD---.-------IHFFDNLIRIVKERLALGGSIFVKITEHSFSPELYSLAG.WFDD.YQLF.C.TAVNASSSEAFLCCFNYLGL.-AKENINGFNLHASYIQWRNEIALTPTYSPLADNPATACKLKATPIISARELEKKPILRYLVASGRLLVRP---------------pecre...................
I6LMN0_9NIDO/6923-7141                 ....................yiswptffvn------------------EPVEKWDLGNYNAPPK-NQSCNVNI..HKFDQMCDFF.A.-T.ELKIPTKGHVHHLGNAG..NV.-YSPGD..IVLKQYFN-QAI.ISGYDLRDVITSSE....LKLPTDQ-......----....-WKCHLLISDVY....EKLTDFT.D-----------LALDYITNHLHLGGSIIWKMTETST-VDVPKIVK.YFGN.WKLI.T.FAINYSSSETFLWCSGYTATdYNESVVQNDIM---------------------------------------------------------------------------sllggyrqdyifvpycndydgnkv
B1PHI6_9ALPC/6689-6988                 ..............................SAEWKCGYSMPSLYKVQRMCLEPCNLYNYGASIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCIPHSMRVLHLGAGS..DK.GVAPGT..SVLRRWLPTDAV.IVDNDVNDYVSDAD....ISVTGDCT......TLYL....QDKFDLVISDMY....DGRIKQM.DGENVSKDGFFVYVNGVITEKLALGGTVAIKITEYSWNKRLYELIQ.KFSY.WTMF.C.TSVNTSSSEAFLIGVNYLGDfATDPIIDGNVLHANYIFWRNSTIMAMSYNSVLDLSKFQCRHKATVVIALKDNDINDVILGLIKNGKLLIRKNGVVCGYGNHLVST-k.......................
A0A125R5A3_9ALPC/6397-6696             ..............................SSEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNV..VKYTQLCQYL.N.TT.TLCVPHKMRVLHLGAAG..AN.GVAPGT..TVLKRWLPDDAI.LVDNDMRDYVSDAD....FSVTGDCT......NLYI....EDKFDLLISDLY....DGSTKSI.DGDNTSKDGFFTYINGFINEKLSLGGSVAIKITEFSWNKSLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGINYLGPyCDKTIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNTLVVNLKERELNDMVVGLLRKGKILIRNNGKLLNFGNHFVNT-p.......................
A0A0F6WGL5_9GAMC/6371-6672             .............................q-SAWKCGYNLPELYKVQTCVMEPCNIPNYGVGITLPSGIMMNV..AKYTQLCQYL.S.KT.TMCVPHNMRVMHFGAGS..DK.GVAPGS..TVLKQWLPEGTL.LVDNDIVDYVSDAH....VSVLSDCN......KYKT....EHKFDLVISDMYtdndSKRKHEG.IVANNGNDDVFIYLANFLRNNLALGGSFAIKVTETSWHDSLYDIAQ.DCAW.WTMF.C.TAVNASSSEAFLVGINYLGD.SGRVKVSGKTLHANYIFWRNVSYLQTSAFTIFDVAKFGLKTKATPVVNLKKELQTDLVLNLIRNGKLVVRDVGNVSFVDDSFVC--c.......................
H9BR16_9NIDO/5999-6279                 ............................vq--ALTNGYQMPSVYKHVQVDRQPCDIKNYHEYVPKYPGVTKNV..LKYRQLCQYI.N.KVdKLAIPHNMTILHLGAAS..IQ.ETAPGT..TVLRQMFPEGTV.IIDLDIRDFVSNAY....QVIVADYR......TYMP....PQHVDVIFSDLY....SNE----.------GESFFKNLVHIVKNRLAIGGSMFIKFTETSYSAELYELAG.YFSD.YNLF.T.TAVNATSSEVWLCCFNYLNE.-CKTVINGEQLHSSYILWRNETILTPTYSTLADNNGLCFKLKATPCVTEKEYVKKPILKLLVAEGKLLVKPPTRC-----------nvl.....................
R1AB_SARS/6777-7073                    ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TVHT....ANKWDLIISDMY....DPRTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVN--n.......................
#=GR R1AB_SARS/6777-7073         SS    ..............................HHTTSSEEE--HHHHT--------S--S-S--TTS-TT--HHH..HHHHHHHHHH.T.TS.-----TT-EEEEES---..TT.SB-HHH..HHHHHHS-TT-E.EEEEESS--B-SSS....EEEES-GG......GEEE....SS-EEEEEE---....-TTS-SS.-S------THHHHHHHHHHHHEEEEEEEEEEE-SSS--HHHHHHHT.TEEE.EEEE.E.EGGGTTSS-EEEEEEEE-SS.--SS---HHHHHHHHHHHHHHS------GGGG--TT-S------EEE---GGG--HHHHHHHHTT-EEES------EEEXXXXX--X.......................
E0ZN51_BCHK9/6630-6922                 .............................k-QDWKPGYSMPALYKVQNAVLEPCLLHNYGQAVRLPTGTLMNV..AKYTQLCQYL.N.TC.TLATPAKMRVIHFGAGS..DK.GVCPGT..AVLKQWLPSDAL.LVDNDLDHCASDAN....FTFVGNCE......LFNT....TYKWDLIISDMY....DARTKQV.SGVNTSKEGFFTYLTGFIRGKLALGGSVAIKLTEHSWSADLYALMG.HFNW.WTCF.C.TSVNSSSSETFLVGVNYLAT.--GTLIDGDQAHANYVFWRNSTLMQLSSYSLYDLQRFQLRTKGTPVMALKEDQLNELVLNLIRAGRLLVRDVGDIAN---------iafst...................
A0A0U1WHD1_9ALPC/6590-6889             ..............................SAEWKCGYSMPSLYKIQRMCLEPCNLYNYGASIRLPDGIMFNV..VKYTQLCQYL.N.ST.TMCVPHNMRVLHLGAGS..DK.GVAPGT..TVLRRWLPDDAV.IVDNDVNDYVSDAD....MSVVGDCT......TLYL....QDKFDLVISDMY....DGRIKHI.DGENVSKDGFFVYLNGVITEKLALGGSVAIKITEHSWNKRTYELIQ.KFAY.WTLF.C.TSVNTSSSEAFLVGINYLGDlNTTPIVDGNVMHANYIFWRNSTIMAMSYNSVLDLSKFECRHKATVVIALKDTDLSEVIVGLIRNGKLLIRKNGSVCGYGTNLVST-k.......................
U5KNA9_9BETC/6841-7138                 ..............................SNDWKPGLAMPSLFKVQNVKLEPCQLVNYGQSMSMPRGVHMNI..AKYMQLAQYL.N.TC.TIAVPANMRVMHFGAGS..DK.GVSPGT..SVLRQWLPSDAV.LIDNDINNFVSDAD....ITLFGDCA......TVRI....GQQVDLVISDMY....DPSTKNV.RESNDSKALFFTYLCNFINRNLALGGSVAIKITEHSWSAELYELMG.KFAW.WTVF.C.TNANASSSEGFLIGVNYLGT.-FKEVIDGSAMHANYIFWRNSTPMNLSTYSLFDLSKFCLKLKGTPILQLKESQINELVVSLLSQGKLLIRDNDTLSVSTDVLVNV-y.......................
A8JNZ0_9ALPC/6428-6727                 ..............................SAEWKCGYSMPSLYKIQNMCMDACNLYNYGASIKLPDGIMFNV..VKYTQLCQFL.N.TT.TMCVPHNMRVLHLGAGS..DK.GVAPGT..AVLRRWLPDDAI.IVDNDVNDYVSDAD....FSITGDCT......HVYV....EDKFDLLISDMY....DGKIKSI.DGDNVSKDGFFTYINGFIREKLALGGAMAVKITEYSWNKQLYEIAQ.KFEY.WTLF.C.TSVNTSSSEAFLIGINYLGDfSSASVIDGNVMHANYIFWRNSTIMTMSYNSVLDLSKFRCKHKATVIITLKDKDITDMVLGLIKNGKLLIRNSQKLLNFSNHLVTT-k.......................
B1PHK0_9ALPC/6597-6896                 ..............................SAEWKCGYSMPSLYKIQRMCLEPCNLYNYGASIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCVPHNMRVLHLGAGS..DK.GVAPGT..TVLRRWLPDDAV.IVDNDVNDYVSDAD....MSVVGDCT......TLYL....QDKFDLVISDMY....DGRIKHI.DGENVSKDGFFVYLNGVITEKLALGGSVAIKITEHSWNKRTYELIQ.KFAY.WTLF.C.TSVNTSSSEAFLIGVNYLGDlNTTPIVDGNVMHANYIFWRNSTIMAMSYNSVLDLSKFECRHKATVVIALKDTDLSEVIVGLIRNGKLLIRKNGSVCGYGNHLVST-k.......................
B2BW31_9GAMC/6363-6663                 ............................ps--VWSPGFNMPELYKVQNCQLEKCELANYGKTVLLPPGILMNV..AKYTQLCQYL.S.KT.TMCVPHNMRVMHFGAGS..DK.GVAPGT..SVLRQWLPEGAL.LIDNDINRYVSDAD....ACVISDCN......VFKS....QGKFDLIISDMYtspkGVDIHEG.IIKNNGISDCFGYLCHFIKNNLSLGGTFAVKITETSWLPELYELAQ.KCAY.WTCF.C.TAVNTSSSEAFLVGVNYLGD.VEKPIIDGSVMHANYLFWRNVTDLPLSARSLFDIAKFGLKVKATPVVNLKKENITELVINLLKNGKIIIRDSVSVHYVDESFIN--........................
A0A0U1WHG0_SARS/6772-7068              ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPIGTL.LVDSDLNDFVSDAD....STLIGECA......TVHT....ANKWDLIVSDMY....DPKTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSVAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGVNYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIVRENNRVIVSSDVLVN--n.......................
Q9J3E8_9BETC/2436-2733                 ..............................AADWKPGYVMPVLYKYLESPLERVNLWNYGKPITLPTGCMMNV..AKYTQLCQYL.S.TT.TLAVPANMRVLHLGAGS..DK.GVAPGS..AVLRQWLPAGSI.LVDNDVNPFVSDSV....ASYYGNCI......TLPF....DCQWDLIISDMY....DPLTKNI.GEYNVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSWNAELYSLMG.KFAF.WTIF.C.TNVNASSSEGFLIGINWLNK.-TRTEIDGKTMHANYLFWRNSTMWNGGAYSLFDMSKFPLKAAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDSLVNV-k.......................
Q0PL13_9ALPC/2381-2680                 ..............................SAEWYPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNV..VKYTQLCQYL.N.TT.TLCVPHKMRVLHLGAAG..AS.GVAPGS..TVLRRWLPDDAI.LVDNDLRDYVSDAD....FSVTGDCT......SLYI....EDKFDLLVSDLY....DGSTKSI.DGENTSKDGFFTYINGFIKEKLSLGGSVAIKITEFSWNKDLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGINYLGPyCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFVNT-p.......................
R1AB_CVPPU/6385-6684                   ..............................SAEWNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNV..VKYTQLCQYL.N.TT.TLCVPHKMRVLHLGAAG..AS.GVAPGS..TVLRRWLPDDAI.LVDNDLRDYVSDAD....FSVTGDCT......SLYI....EDKFDLLVSDLY....DGSTKSI.DGENTSKDGFFTYINGFIKEKLSLGGSVAIKITEFSWNKDLYELIQ.RFEY.WTVF.C.TSVNTSSSEGFLIGINYLGPyCDKAIVDGNIMHANYIFWRNSTIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNHFVNT-p.......................
R9QTA1_SARS/2332-2628                  ..............................SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNV..AKYTQLCQYL.N.TL.TLAVPYNMRVIHFGAGS..DK.GVAPGT..AVLRQWLPTGTL.LVDSDLNDFVSDAD....STLIGDCA......TIHT....ANKWDLIISDMY....DPKTKHV.TKENDSKEGFFTYLCGFIKQKLALGGSVAVKITEHSWNADLYKLMG.HFSW.WTAF.V.TNVNASSSEAFLIGANYLGK.-PKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVN--n.......................
A3EXE7_BCHK5/6873-7170                 .............................i-NDWKPGLAMPSLFKVQNSNLEPCMLPNYKQSIPMPQGVHMNI..AKYMQLCQYL.N.TC.TIAVPANMRVMHFGAGS..DK.GVAPGS..SVLRQWLPTDAI.LIDNDLNEYVSDAD....ITLFGDCV......TVRV....GQQVDLLISDMY....DPSTKVV.GETNEAKALFFVYLCNFIKNNLALGGSVAIKITEHSWSAELYELMG.RFAW.WTVF.C.TNANASSSEGFLIGINYLGE.-LKEVIDGNVMHANYIFWRNTTLMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLIIRDNDTLSVSTDVLVN--fy......................
E0ZN59_BCHK9/6610-6903                 .............................k-QDWKPGFSMPALYKVQNAVLEPCLLHNYGQAARLPSGTLMNV..AKYTQLCQYL.N.NC.SLAVPAKMRVIHFGAGS..DK.GVCPGT..SVLKQWLPTDAF.LVDNDLDRCASDAN....ATFVGNCE......LFAT....PHKWDLIISDMY....DARTKNV.SGENISKEGFFTYLTGFIKSKLSLGGSVAIKITEHSWSADLYAMMG.HFEW.WTCF.C.TAVNSSSSEAFLIGINYLGI.--GALLDGEQMHANYIFWRNSTIMQLSSYSLFDVQKFGLRAKGTPVMVLKEEQVNELVLNLIRTGRLIVRDVGDIVNVTTSF----c.......................
S5YAF0_9ALPC/6526-6825                 ..............................SAEWKCGYSMPALYKIQRMCLEPCNLYNYGAGIKLPDGIMFNV..VKYTQLCQYL.N.ST.TMCVPHHMRCLHLGAGS..DK.GVAPGT..AVLKRWLPIDAV.IVDNDVNDYVSDAD....FSYTGDCT......TLYL....ADKFDLVISDMY....DGKIKLC.DGDNVSKEGFFTYINGVICEKLAIGGTVAIKITEHSWNKRLYELIQ.RFEY.WTMF.C.TSVNTSSSESFLIGVHYLGDyATTPVIDGNTMHANYIFWRNSTMMTMSYNSVLDLSKFACKHKATVVVNLKENAISDLVVSLVRSGKLLVRGSGPLVNLSNHLVNT-k.......................
#=GC SS_cons                           ..............................HHCCSSEEE--HHHHT--------S-TTTT--TTSSTT--HHH..HHHHHHHHHH.T.TS.----BTT-EEEEES---..TT.SB-HHH..HHHHHHS-TT-E.EEEEESS--B-SSS....EEEES-GG......GEEE....SS-EEEEEE---....-CCCHCT.TS------THHHHHHHHHHHHEEEEEEEEEEE-SSS--HHHHHHHT.TEEE.EEEE.E.EGGGTTSS-EEEEEEEE-SS.--SS---HHHHHHHHHHHHHHS------GGGG--TT-S-----BEEE---GGG--HHHHHHHHTT-EEES--S--EEEEXEEXX--X.......................
#=GC seq_cons                          ...............................s-WpPGYuMPsLYKhQphsLE.CsLhNYGpslpLPsGlhhNV..sKYTQLCQYL.N.Ts.TLsVPaNMRVlHLGAGS..DK.GVAPGo..uVLRQWLPssul.LVDNDls-aVSDAD....holhGDCs......Tlhh....ssKaDLlISDMY....DspTKpl.stpNsSK-GFFsYlsshI+pKLALGGSVAIKITEaSWNs-LYcLhs.+Fua.WThF.C.TsVNuSSSEuFLIGlNYLGc..s+t.IDGssMHANYIFWRNSThhshSt.SLhDhuKFslKh+uTsVlsLK-splN-hVluLlcpGKLLlRcssphsh.us.LVs..h.......................
//
DBGET integrated database retrieval system