GenomeNet

Database: Pfam
Entry: CoV_NSP10
LinkDB: CoV_NSP10
Original site: CoV_NSP10 
#=GF ID   CoV_NSP10
#=GF AC   PF09401.12
#=GF DE   Coronavirus RNA synthesis protein NSP10
#=GF PI   NSP10; nsp10;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF SE   pdb_2fyg
#=GF GA   27.20 27.20;
#=GF TC   28.10 27.20;
#=GF NC   25.60 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16873246
#=GF RT   Crystal structure of nonstructural protein 10 from the severe
#=GF RT   acute respiratory syndrome coronavirus reveals a novel fold with
#=GF RT   two zinc-binding motifs. 
#=GF RA   Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Brooun A,
#=GF RA   Griffith M, Moy K, Yadav MK, Velasquez J, Buchmeier MJ, Stevens
#=GF RA   RC, Kuhn P; 
#=GF RL   J Virol. 2006;80:7894-7901.
#=GF RN   [2]
#=GF RM   27712628
#=GF RT   The Nonstructural Proteins Directing Coronavirus RNA Synthesis
#=GF RT   and Processing.
#=GF RA   Snijder EJ, Decroly E, Ziebuhr J;
#=GF RL   Adv Virus Res. 2016;96:59-126.
#=GF RN   [3]
#=GF RM   29279395
#=GF RT   Structural and molecular basis of mismatch correction and
#=GF RT   ribavirin excision from coronavirus RNA.
#=GF RA   Ferron F, Subissi L, Silveira De Morais AT, Le NTT, Sevajol M,
#=GF RA   Gluais L, Decroly E, Vonrhein C, Bricogne G, Canard B, Imbert I;
#=GF RL   Proc Natl Acad Sci U S A. 2018;115:E162.
#=GF RN   [4]
#=GF RM   25074927
#=GF RT   Coronavirus Nsp10, a critical co-factor for activation of
#=GF RT   multiple replicative enzymes.
#=GF RA   Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi
#=GF RA   S, Imbert I, Canard B, Guillemot JC, Lecine P, Pfefferle S,
#=GF RA   Drosten C, Snijder EJ, Decroly E, Morelli X;
#=GF RL   J Biol Chem. 2014;289:25783-25796.
#=GF DR   INTERPRO; IPR018995;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Non-structural protein 10 (NSP10) is involved in RNA synthesis.
#=GF CC   It is synthesised as a polyprotein whose cleavage generates many
#=GF CC    non-structural proteins. NSP10 contains two zinc binding motifs
#=GF CC   and forms two anti-parallel helices which are stacked against an
#=GF CC   irregular beta sheet [1]. A cluster of basic residues on the
#=GF CC   protein surface suggests a nucleic acid-binding function. NSP10
#=GF CC   interacts with NSP14 and NSP16 and regulates their respective
#=GF CC   ExoN and 2-O-MTase activities [2]. When binding to the
#=GF CC   N-terminal of NSP14, nsp10 allows the ExoN active site to adopt
#=GF CC   a stably closed conformation [3] and is an allosteric regulator
#=GF CC   that stabilizes NSP16. The residue Tyr-96 plays a crucial role
#=GF CC   in the NSP10-NSP16/NSP14 interaction. This residue is specific
#=GF CC   for SARS-CoV NSP10 and is a phenylalanine in most other
#=GF CC   Coronavirus homologues [4].
#=GF SQ   111
#=GS B1PHJ4_9ALPC/4124-4245      AC B1PHJ4.1
#=GS A0A0P0LKV0_CVH22/3947-4068  AC A0A0P0LKV0.1
#=GS R1AB_CVHOC/4241-4362        AC P0C6X6.1
#=GS E0ZN59_BCHK9/4078-4200      AC E0ZN59.1
#=GS R1AB_SARS/4239-4361         AC P0C6X7.1
#=GS R1AB_SARS/4239-4361         DR PDB; 5NFY N; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5C8S C; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 2XYQ B; 10-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5NFY P; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 2XYR B; 12-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5NFY O; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 2XYV B; 11-129;
#=GS R1AB_SARS/4239-4361         DR PDB; 5C8S A; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5C8T C; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5C8U A; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5C8T A; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5C8U C; 9-131;
#=GS R1AB_SARS/4239-4361         DR PDB; 5NFY M; 9-131;
#=GS S5YAF0_9ALPC/4016-4137      AC S5YAF0.1
#=GS D9J202_9ALPC/3861-3982      AC D9J202.1
#=GS R1AB_BCHK4/4290-4411        AC P0C6W3.1
#=GS E0ZN51_BCHK9/4098-4220      AC E0ZN51.1
#=GS A0A023YA54_MERS/4347-4469   AC A0A023YA54.1
#=GS K4K1U5_9ALPC/3970-4091      AC K4K1U5.1
#=GS B1PHK0_9ALPC/4087-4208      AC B1PHK0.1
#=GS A3EXC0_BCHK4/4300-4421      AC A3EXC0.1
#=GS A0A0U1UZC3_9ALPC/3846-3967  AC A0A0U1UZC3.1
#=GS B8Q8U6_SARS/4239-4361       AC B8Q8U6.1
#=GS A0A0U1WHG1_9ALPC/3790-3911  AC A0A0U1WHG1.1
#=GS B1PHI6_9ALPC/4180-4301      AC B1PHI6.1
#=GS Q0PL14_9ALPC/3869-3990      AC Q0PL14.1
#=GS R1AB_BC279/4245-4367        AC P0C6V9.1
#=GS A0A0U1UZ20_9ALPC/4087-4208  AC A0A0U1UZ20.1
#=GS R1A_SARS2/4262-4384         AC P0DTC1.1
#=GS R1A_BCHK5/4337-4458         AC P0C6T5.1
#=GS A8JNZ0_9ALPC/3916-4037      AC A8JNZ0.1
#=GS B1PHJ3_9ALPC/4124-4245      AC B1PHJ3.1
#=GS R1AB_IBVB/3793-3918         AC P0C6Y1.1
#=GS B6VDX7_THCOV/3475-3594      AC B6VDX7.1
#=GS A0A0P0ILY9_CVH22/3947-4068  AC A0A0P0ILY9.1
#=GS A0A0F6SKM6_9GAMC/3823-3948  AC A0A0F6SKM6.1
#=GS R1A_CVMA5/4326-4447         AC P0C6V0.1
#=GS R1AB_CVH22/3942-4063        AC P0C6X1.1
#=GS T2B9U0_MERS/4246-4368       AC T2B9U0.1
#=GS Q06BE1_9BETC/4241-4362      AC Q06BE1.2
#=GS A0A0U2UMS4_9ALPC/3870-3991  AC A0A0U2UMS4.1
#=GS B1PHI7_9ALPC/4180-4301      AC B1PHI7.1
#=GS B1PHK1_9ALPC/4087-4208      AC B1PHK1.1
#=GS A0A0A7UXR0_9BETC/4288-4409  AC A0A0A7UXR0.1
#=GS T2B9I2_MERS/4246-4368       AC T2B9I2.1
#=GS R1AB_CVMJH/4332-4453        AC P0C6Y0.1
#=GS A0A0F6WGL5_9GAMC/3823-3948  AC A0A0F6WGL5.1
#=GS A0A125R5A4_9ALPC/3884-4005  AC A0A125R5A4.1
#=GS Q0ZJB1_CVHK1/4328-4449      AC Q0ZJB1.1
#=GS C0KYZ6_9BETC/4331-4452      AC C0KYZ6.1
#=GS A0A240FW17_9ALPC/3524-3645  AC A0A240FW17.1
#=GS R1AB_BC512/3985-4106        AC P0C6W0.1
#=GS A0A096XNJ3_9ALPC/3933-4054  AC A0A096XNJ3.2
#=GS R9QTB2_SARS/4231-4353       AC R9QTB2.1
#=GS A0A0K2RVJ3_9BETC/4276-4397  AC A0A0K2RVJ3.1
#=GS R1A_CVHOC/4241-4362         AC P0C6U7.1
#=GS A0A088DIE1_9BETC/4405-4527  AC A0A088DIE1.1
#=GS H9TEX0_9ALPC/3873-3994      AC H9TEX0.1
#=GS B8Q8U7_SARS/4239-4361       AC B8Q8U7.1
#=GS H9BZX6_9BETC/4329-4450      AC H9BZX6.1
#=GS B2BW32_9GAMC/3767-3888      AC B2BW32.1
#=GS A0A0K1RLM9_9ALPC/3868-3989  AC A0A0K1RLM9.1
#=GS R1A_SARS/4239-4361          AC P0C6U8.1
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T I; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 H; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T S; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T C; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 I; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 N; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T N; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T X; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 R; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T M; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 B; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 J; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T V; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 E; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T J; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T A; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 W; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T B; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 D; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T H; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T Q; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T R; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T T; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T D; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 F; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 U; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 A; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 C; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T F; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 Q; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 S; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T K; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T U; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T W; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 L; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T P; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 3R24 B; 10-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 G; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T O; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T L; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 K; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2FYG A; 10-131;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 V; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 T; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 M; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 X; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T G; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 O; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2GA6 P; 9-129;
#=GS R1A_SARS/4239-4361          DR PDB; 2G9T E; 9-129;
#=GS R1A_CVH22/3942-4063         AC P0C6U2.1
#=GS D9J203_9ALPC/3861-3982      AC D9J203.1
#=GS R1A_IBVB/3793-3918          AC P0C6V3.1
#=GS B2BW31_9GAMC/3767-3888      AC B2BW31.1
#=GS A0A140ESF0_9NIDO/3496-3615  AC A0A140ESF0.1
#=GS A0A0U1WHD1_9ALPC/4080-4201  AC A0A0U1WHD1.1
#=GS A8JNZ1_9ALPC/3916-4037      AC A8JNZ1.1
#=GS R1AB_FIPV/3897-4018         AC Q98VG9.2
#=GS R1A_CVPPU/3872-3993         AC P0C6V2.1
#=GS R1AB_SARS2/4262-4384        AC P0DTD1.1
#=GS R1AB_SARS2/4262-4384        DR PDB; 6W61 B; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WVN B; 4263-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 7C2I B; 18-131;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WJT D; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6W75 D; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6W4H B; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WJT B; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 7C2J B; 19-131;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WKQ D; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6W75 B; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6ZCT A; 10-131;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WKQ B; 4271-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WQ3 B; 4264-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6WRZ B; 4264-4384;
#=GS R1AB_SARS2/4262-4384        DR PDB; 7BQ7 B; 18-130;
#=GS R1AB_SARS2/4262-4384        DR PDB; 6XKM B; 18-131;
#=GS A0A0U1UZA8_9ALPC/4123-4244  AC A0A0U1UZA8.1
#=GS A0A0K2RW65_9BETC/4276-4397  AC A0A0K2RW65.1
#=GS R1A_BC279/4245-4367         AC P0C6F5.1
#=GS A3EXE7_BCHK5/4336-4457      AC A3EXE7.1
#=GS B8Q8S4_SARS/4239-4361       AC B8Q8S4.1
#=GS R1AB_CVM2/4274-4395         AC P0C6X8.1
#=GS A0A0K1Z0N1_SARS/4239-4361   AC A0A0K1Z0N1.1
#=GS R1AB_BCHK5/4337-4458        AC P0C6W4.1
#=GS R1A_BC512/3985-4106         AC P0C6F6.1
#=GS Q6UZF5_SARS/4239-4361       AC Q6UZF5.1
#=GS F2YDB2_SARS/4239-4361       AC F2YDB2.1
#=GS R1AB_CVMA5/4326-4447        AC P0C6X9.1
#=GS A0A0U1WHG4_9ALPC/3932-4053  AC A0A0U1WHG4.1
#=GS H9BR24_9NIDO/3439-3558      AC H9BR24.1
#=GS A0A0F6PN25_9NIDO/2989-3094  AC A0A0F6PN25.1
#=GS R1A_BCHK9/4103-4225         AC P0C6T6.1
#=GS F2YDB1_SARS/4239-4361       AC F2YDB1.1
#=GS A0A1X9JQL5_9ALPC/3829-3950  AC A0A1X9JQL5.1
#=GS A0A0U1UZ65_BCHK4/4298-4419  AC A0A0U1UZ65.1
#=GS R1AB_CVPPU/3872-3993        AC P0C6Y5.1
#=GS A3EXI9_BCHK9/4098-4220      AC A3EXI9.1
#=GS H9TEW9_9ALPC/3873-3994      AC H9TEW9.1
#=GS A0A0U1WHK4_SARS/4239-4361   AC A0A0U1WHK4.1
#=GS Q9J3E9_9BETC/4325-4446      AC Q9J3E9.1
#=GS R1AB_BCHK9/4103-4225        AC P0C6W5.1
#=GS A0A0U1WHG0_SARS/4234-4356   AC A0A0U1WHG0.1
#=GS H9BR16_9NIDO/3475-3594      AC H9BR16.1
#=GS H9BQZ9_9NIDO/3506-3625      AC H9BQZ9.1
#=GS U5LR11_9BETC/4309-4431      AC U5LR11.1
#=GS A3EXA2_BCHK4/4290-4411      AC A3EXA2.1
#=GS H9BR34_9NIDO/3399-3518      AC H9BR34.1
#=GS R1A_BCHK4/4290-4411         AC P0C6T4.1
#=GS R1A_CVM2/4274-4395          AC P0C6U9.1
#=GS H9BZX5_9BETC/4329-4450      AC H9BZX5.1
#=GS R1A_CVMJH/4332-4453         AC P0C6V1.1
#=GS A0A1B3Q5W8_9BETC/4145-4267  AC A0A1B3Q5W8.1
#=GS S5Z1D1_9ALPC/4016-4137      AC S5Z1D1.1
#=GS H9BR07_9NIDO/3484-3603      AC H9BR07.1
#=GS B7U2M9_9BETC/4241-4362      AC B7U2M9.1
#=GS V5TFR4_9GAMC/3767-3888      AC V5TFR4.1
#=GS E0XIZ2_9BETC/4230-4352      AC E0XIZ2.1
#=GS B8Q8S5_SARS/4239-4361       AC B8Q8S5.1
#=GS H9AA60_9BETC/4262-4383      AC H9AA60.1
#=GS A0A0K1YZY7_SARS/4239-4361   AC A0A0K1YZY7.1
#=GS A0A125R5A3_9ALPC/3884-4005  AC A0A125R5A3.1
#=GS U5KNA9_9BETC/4309-4431      AC U5KNA9.1
B1PHJ4_9ALPC/4124-4245                 ............v-NSSLLTLCSFAVDPAKCYLDAVKSGVKPVNNCVKM..LSNGSGTGQAVTVGVEANTNQDSYGGASVCLYCRAHVDHP....SIDGFCQFKGRYVQIPVG.TV.DPIRFCLENQ.VCKVCHCWLNNGCSC-g.....
A0A0P0LKV0_CVH22/3947-4068             .............SNSLLLTHCSFAVDPAAAYLDAVRQGAKPVGNCVKM..LTNGSGSGQAITSTIDSNTTQDTYGGASVCIYCRAHVAHP....TMDGFCQYKGKWVQVPIG.TN.DPIRFCLENT.VCRVCGCWLNHGCTCD......
R1AB_CVHOC/4241-4362                   .............SNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKM..LCDHAGTGMAITVKPDATTSQDSYGGASVCIYCRARVEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYVLTHD.VCRVCGFWRDGSCSC-v.....
E0ZN59_BCHK9/4078-4200                 .............SNSSILSLCAFSVDPEATYKEYLDNGGSPIGNCVKM..LTPHTGTGLAITAKPDANIEQESFGGASCCLYCRCHIEHP....GASGVCKYKGKFVQIPQVgVN.DPIGFCIRNV.VCAVCNMWQGYGCPC-a.....
R1AB_SARS/4239-4361                    .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
#=GR R1AB_SARS/4239-4361         SS    .............GGHHHHHHHHHBSSHHHHHHHHHHTT--------BB..---SBS-S-SEESS--B-TTEEEEEGGGG-HHHHTT---S....SSSS--SSTTSEEEEETTGTT.SHHHHHHHSE.BETTTSSBTTSSBS--......
S5YAF0_9ALPC/4016-4137                 ............m-NSSLLTMCAFSTDPAKTYLDAVKSGVKPIGNCVKM..LANGAGNGQAITNGVEANTSQDSYGGASVCLWCRAYVEHP....AMDGFCKYRGKYVQVPIG.TV.DPIRYCLENE.VCKVCGCWLNNGCSCD......
D9J202_9ALPC/3861-3982                 .............SNSSLLTLCAFAPEPAKAYVELVKKGMQPVNNCVKM..LSNGSGNGMAITNGVEATPNQDSYGGASVCIYCRSHTAHP....SIDGMCRFKGKFVQVPAG.TV.DPIRFCIEND.TCAVCACWLNNGCVCD......
R1AB_BCHK4/4290-4411                   .............SNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKM..LAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHP....DVSGVCKYKTRFVQIPAH.VR.DPVGFLLKNV.PCNVCQYWVGYGCNCD......
E0ZN51_BCHK9/4098-4220                 .............SNSSILSLCAFSVDPEATYKDYLDNGGSPIGNCVKM..LTPHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHP....GASGVCKYKGKFVQIPIVgVN.DPIGFCIRNI.VCAVCNMWQGYGCPC-a.....
A0A023YA54_MERS/4347-4469              .............SNSSVLSLVTFTVDPKKAYMDFVNAGGAPLTNCVKM..LTPKTGTGIAISVKPESNADQETYGGASVCLYCRAHIEHP....DVSGVCKFKGRFVQIPSQcTR.DPVGFCLTND.PCPLCQYWKGYGCNCD......
K4K1U5_9ALPC/3970-4091                 ............v-NSPLLTMCAFAVDPAKTYLDAVKRGAKPVGNCIKM..LANGSGTGQAVTTGVEANTNQDSYGGASVCLYCRAHVEHP....SMDGYCKLKGRYVQVPMG.TI.DPIRFVLENE.ACKVCQCWLNNGCACD......
B1PHK0_9ALPC/4087-4208                 .............ANSSLLTMCSFAVDPRKCYLDAVKNGVKPVTNCVKM..LSNGSGTGQAVTVGVEANTNQDSYGGASVCLYCRAHIDHP....SMDGFCQFKGRYVQVPIG.TV.DPIRYCLEND.ICKVCHCWLNNGCTCD......
A3EXC0_BCHK4/4300-4421                 .............SNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKM..LAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHP....DVSGVCKYKTRFVQIPAH.VR.DPVGFLLKNV.PCNVCQYWVGYGCNCD......
A0A0U1UZC3_9ALPC/3846-3967             .............ANSSLLTMCAFAVDPAKCYLDAVKGGVKPVGNCIKM..LSNGSGNGQAITNGVESNTSQDTYGGASVCLYCRAHVDHP....SMDGFCRLKGKYVQVPLG.TL.DPIRYCLENT.VCKVCACWLNNGCQCE......
B8Q8U6_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
A0A0U1WHG1_9ALPC/3790-3911             ............t-NSSLLTLCAFAVDPPKMYIDSVKAGIKPVGNCVKM..LSNGAGNGQAITTSVEANTNQDSYGGASVCLYCRAHVEHP....GMDGRCQFKGRYVQVPLG.TA.DPIRFCLENK.VCSVCGCWFGHGCTCD......
B1PHI6_9ALPC/4180-4301                 ............v-NSSLLTLCSFAVDPAKCYLYAVKSGVKPINNCVKM..LSNGSGTGQAVTVGVEATTNQDSYGGASVCLYCRAHVDHP....SIDGFCQFKGRYVQVPVG.TV.DPIRFCLENQ.VCKVCHCWLNNGCSCD......
Q0PL14_9ALPC/3869-3990                 .............SNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQIPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
R1AB_BC279/4245-4367                   .............ANSAVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPATcAN.DPVGFTLKNT.VCTVCGTWKGYGCSCD......
A0A0U1UZ20_9ALPC/4087-4208             .............ANSSLLTMCSFAVDPKKCYLDAVKNGVKPVTNCVKM..LSNGSGTGQAVTVGVEANTNQDSYGGASVCLYCRAHIDHP....SMDGFCQFKGRYVQVPIG.TV.DPIRYCLEND.ICKVCHCWLNNGCTCD......
R1A_SARS2/4262-4384                    .............ANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLKNT.VCTVCGMWKGYGCSCD......
R1A_BCHK5/4337-4458                    ............i-NSSVLSAVTFSVDPGKAYLDFVNAGGAPLTNCVKM..LTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHIEHP....DVTGVCKFKGKFVQVPLH.IR.DPVGFCLQNT.PCNVCQFWIGHGCNCD......
A8JNZ0_9ALPC/3916-4037                 ............c-NSSLLTLCAFAVDPAKAYVSAVKQGAKPVGNCVKM..LANGSGSGQAVTNGVEANMNQDSYGGASVCIYCRAHVDHP....AMDGACRFKGKYVQIPIG.VN.DPIRFCIENE.VCKVCGCWLNNGCSCD......
B1PHJ3_9ALPC/4124-4245                 ............v-NSSLLTLCSFAVDPAKCYLDAVKSGVKPVNNCVKM..LSNGSGTGQAVTVGVEANTNQDSYGGASVCLYCRAHVDHP....SIDGFCQFKGRYVQIPVG.TV.DPIRFCLENQ.VCKVCHCWLNNGCSC-g.....
R1AB_IBVB/3793-3918                    ..........dav---GILSLCSFAVDPADTYCKYVAAGNQPLGNCVKM..LTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPgsvgNLDGRCQFKGSFVQIPTT.EK.DPVGFCLRNK.VCTVCQCWIGYGCQCD......
B6VDX7_THCOV/3475-3594                 .............ENASLLTYLAFAVNPKEAYLKHLADGGNPIRGCIQM..IAS-LGPGFAVTTKPQPNEHQYSYGGASICLYCRAHIPHP....GADGRCLYKGRFVQIDKD.-K.EPISFALTHE.PCNACQHWVNYDCTC-g.....
A0A0P0ILY9_CVH22/3947-4068             .............SNSLLLTHCSFAVDPAAAYLDAVRQGAKPVGNCVKM..LTNGSGSGQAITSTIDSNTTQDTYGGASVCIYCRAHVAHP....TMDGFCQYKGKWVQVPIG.TN.DPIRFCLENT.VCRVCGCWLNHGCTCD......
A0A0F6SKM6_9GAMC/3823-3948             ...........es--VGILSLCAFAVNPEETYLKYVSAGNQPLGNCVKM..LTVHNGNGFAITTKPSPTPDQDSYGGASVCLYCRAHIAHPgasgTLDGRCPFKGSFVQIPTS.EK.DPVGFCLRNK.VCKVCQCWVGFGCQCD......
R1A_CVMA5/4326-4447                    .............SNSAILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
R1AB_CVH22/3942-4063                   .............SNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGNCVKM..LTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHP....TMDGFCQYKGKWVQVPIG.TN.DPIRFCLENT.VCKVCGCWLNHGCTCD......
T2B9U0_MERS/4246-4368                  .............SNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNCVKM..LTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHP....DVSGVCKYKGKFVQIPAQcVR.DPVGFCLSNT.PCNVCQYWIGYGCNCD......
Q06BE1_9BETC/4241-4362                 .............SNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKM..LCDHAGTGMAITVKPDATTNQDSYGGASVCIYCRARVEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
A0A0U2UMS4_9ALPC/3870-3991             .............SNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQVPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
B1PHI7_9ALPC/4180-4301                 ............v-NSSLLTLCSFAVDPAKCYLYAVKSGVKPINNCVKM..LSNGSGTGQAVTVGVEATTNQDSYGGASVCLYCRAHVDHP....SIDGFCQFKGRYVQVPVG.TV.DPIRFCLENQ.VCKVCHCWLNNGCSCD......
B1PHK1_9ALPC/4087-4208                 .............ANSSLLTMCSFAVDPRKCYLDAVKNGVKPVTNCVKM..LSNGSGTGQAVTVGVEANTNQDSYGGASVCLYCRAHIDHP....SMDGFCQFKGRYVQVPIG.TV.DPIRYCLEND.ICKVCHCWLNNGCTCD......
A0A0A7UXR0_9BETC/4288-4409             .............ANSAILSLCAFSVDPKKTYLDYIQQGGIPIANCVKM..LCDHAGTGMAITVKPDATTNQDSYGGASVCIYCRARIEHP....DVDGLCKLRGKFVQVPIG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
T2B9I2_MERS/4246-4368                  .............SNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNCVKM..LTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHP....DVSGVCKYKGKFVQIPAQcVR.DPVGFCLSNT.PCNVCQYWIGYGCNCD......
R1AB_CVMJH/4332-4453                   .............SNSAILSLCAFSVDPKKTYLDYIQQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
A0A0F6WGL5_9GAMC/3823-3948             ...........es--VGILSLCAFAVNPEETYLKYVSAGNQPLGNCVKM..LTVHNGNGFAITTKPSPTPDQDSYGGASVCLYCRAHIAHPgasgTLDGRCPFKGSFVQIPTS.EK.DPVGFCLRNK.VCKVCQCWVGFGCQCD......
A0A125R5A4_9ALPC/3884-4005             .............SNSGLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKM..LSNGAGNGMAITNGVESNTQQDSYGGASVCIYCRCHVEHP....AIDGLCRFKGKFVQVPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
Q0ZJB1_CVHK1/4328-4449                 .............ANSSILSLCAFSVDPKKTYLDYIQQGGVPIINCVKM..LCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHP....DVDGLCKLRGKFVQVPLG.IK.DPILYVLTHD.VCQVCGFWRDGSCSC-v.....
C0KYZ6_9BETC/4331-4452                 .............SNSAILSLCAFSVDPKKTYLDYIQQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
A0A240FW17_9ALPC/3524-3645             .............ENSNLLSICAFAVDPAKAYLDAIKSGVKPLTNCIKM..LSNGSGNGQAVSYTVDAKTNQDSYGGASVCIYCRAYVEHP....TVDGLCQFKGRFVQVPLG.TK.DPVGFCIENS.ICSVCKCWIGHGCVCD......
R1AB_BC512/3985-4106                   ............t-NSSLLTLCAFAVDPPKTYLDAVKSGHRPVGNCVKM..LANGSGNGQAITNGVEASTNQDSYGGASVCLYCRAHVEHP....DMDGFCKLRGKYVQVPLG.TL.DPIRFVLENT.VCKVCGCWQANGCTCD......
A0A096XNJ3_9ALPC/3933-4054             ...........td--CQLLTLCAFAVDPKDAYLTAVRQGHKPLSNCIKM..INNGSGNGLAITHRVEANTVQDSYGGASCCLYCRASVEHP....GMNGICNLRGKYVQVPTG.TT.DPVRFVLENE.VCSVCSCWLGHGCVCD......
R9QTB2_SARS/4231-4353                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
A0A0K2RVJ3_9BETC/4276-4397             .............SNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKM..LCDHAGTGMAITIKPEATTSQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
R1A_CVHOC/4241-4362                    .............SNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKM..LCDHAGTGMAITVKPDATTSQDSYGGASVCIYCRARVEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYVLTHD.VCRVCGFWRDGSCSC-v.....
A0A088DIE1_9BETC/4405-4527             ............a-NSKCLTFCAFAVDPEKAYFDFVNSGGQPLNNCVRV..LCTHTGTGRAITADPEATADQESYGGSSCCLYCRCHISHP....SHNGLCKYKGKYVQIPNVcTN.DPVGFLLKNT.VCNVCACWIGYGCNCD......
H9TEX0_9ALPC/3873-3994                 .............SNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAITNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQIPTG.TQ.DPIRFCIENE.VCVVCGCWFNNGCMCD......
B8Q8U7_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
H9BZX6_9BETC/4329-4450                 .............SNSAILSLCAFSVDPKKTYLDYIQQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCAFWRDGSCSC-v.....
B2BW32_9GAMC/3767-3888                 .............ENCGILSLCSFALDAKECYLEYIKEGGAPLSNCVKM..LTLHTGSGAAVTVKPAPTPEQDSFGGASVCLYCRAHISHP....GVYGVCQFKGKFVQIPVE.EK.DPVGFCLRNK.ICTVCQMWIGFGCQCD......
A0A0K1RLM9_9ALPC/3868-3989             .............SNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQIPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
R1A_SARS/4239-4361                     .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
#=GR R1A_SARS/4239-4361          SS    .............THHHHHHHHHTSSSHHHHHHHHHHTT--------BE..E-SSBS---SEESS---BTTEEEEEHGGG-HHHHHT---S....SSSSS-SSTTSEEEEEGGGTT.-HHHHHHH--.B-TTTSSBTTTB--XX......
R1A_CVH22/3942-4063                    .............SNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGNCVKM..LTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHP....TMDGFCQYKGKWVQVPIG.TN.DPIRFCLENT.VCKVCGCWLNHGCTCD......
D9J203_9ALPC/3861-3982                 .............SNSSLLTLCAFAPEPAKAYVELVKKGMQPVNNCVKM..LSNGSGNGMAITNGVEATPNQDSYGGASVCIYCRSHTAHP....SIDGMCRFKGKFVQVPAG.TV.DPIRFCIEND.TCAVCACWLNNGCVCD......
R1A_IBVB/3793-3918                     ..........dav---GILSLCSFAVDPADTYCKYVAAGNQPLGNCVKM..LTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPgsvgNLDGRCQFKGSFVQIPTT.EK.DPVGFCLRNK.VCTVCQCWIGYGCQCD......
B2BW31_9GAMC/3767-3888                 .............ENCGILSLCSFALDAKECYLEYIKEGGAPLSNCVKM..LTLHTGSGAAVTVKPAPTPEQDSFGGASVCLYCRAHISHP....GVYGVCQFKGKFVQIPVE.EK.DPVGFCLRNK.ICTVCQMWIGFGCQCD......
A0A140ESF0_9NIDO/3496-3615             ............q-NASLLTYLAFAVDPKTAYLKHLADGGSPIQGCIQM..IAT-MGPGFAVTTKPQPNEHQYSYGGASICLYCRAHIPHP....GVDGRCPYKGRFVHIDKD.-K.EPVSFALTHE.PCSSCQRWVNYDCTC-g.....
A0A0U1WHD1_9ALPC/4080-4201             .............ANSSLLTMCSFAVDPKKCYLDAVKNGIKPVTNCVKM..LSNGSGTGQAVTVGVEANTNQDSYGGASVCLYCRAHIDHP....NMDGFCQFKGRYVQVPVG.TV.DPIRYCLEND.ICKVCHCWLNNGCTCD......
A8JNZ1_9ALPC/3916-4037                 ............c-NSSLLTLCAFAVDPAKAYVSAVKQGAKPVGNCVKM..LANGSGSGQAVTNGVEANMNQDSYGGASVCIYCRAHVDHP....AMDGACRFKGKYVQIPIG.VN.DPIRFCIENE.VCKVCGCWLNNGCSCD......
R1AB_FIPV/3897-4018                    .............SNSGLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKM..LSNGAGNGMAITNGVESNTQQDSYGGASVCIYCRCHVEHP....AIDGLCRFKGKFVQVPTG.TQ.DPIRFCIENE.VCVVCGCWLTNGCMCD......
R1A_CVPPU/3872-3993                    .............SNSSLLTLCAFSPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQIPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
R1AB_SARS2/4262-4384                   .............ANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLKNT.VCTVCGMWKGYGCSCD......
#=GR R1AB_SARS2/4262-4384        SS    .............XHHHHHHHHHCCSSHHHHHHHHHHTT--------B-..---S-S---SEESS----TTEEEEESGGG-HHHHHT---S....STTG--SSTTSEEEEEGGGTT.-HHHHHHH--.B-TTTSSBTTTBE-TT......
A0A0U1UZA8_9ALPC/4123-4244             ............v-NSSLLTLCSFAVDPAKCYLDAVKSGVKPVNNCVKM..LSNGSGTGQAITVGVEANTNQDSYGGASVCLYCRAHVDHP....SIDGFCQFKGRYVQIPVG.TV.DPIRFCLENQ.VCKVCHCWLNNGCSCD......
A0A0K2RW65_9BETC/4276-4397             .............SNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKM..LCDHAGTGMAITIKPEATTSQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
R1A_BC279/4245-4367                    .............ANSAVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPATcAN.DPVGFTLKNT.VCTVCGTWKGYGCSCD......
A3EXE7_BCHK5/4336-4457                 ............i-NSSVLSAVTFSVDPGKAYLDFVNAGGAPLTNCVKM..LTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHIEHP....DVTGVCKFKGKFVQVPLH.VR.DPVGFCLQNT.PCNVCQFWIGHGCNCD......
B8Q8S4_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
R1AB_CVM2/4274-4395                    .............SNSAIRSLCAFSVDPKKTYLDYIQQGGAPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
A0A0K1Z0N1_SARS/4239-4361              .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYIQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
R1AB_BCHK5/4337-4458                   ............i-NSSVLSAVTFSVDPGKAYLDFVNAGGAPLTNCVKM..LTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHIEHP....DVTGVCKFKGKFVQVPLH.IR.DPVGFCLQNT.PCNVCQFWIGHGCNCD......
R1A_BC512/3985-4106                    ............t-NSSLLTLCAFAVDPPKTYLDAVKSGHRPVGNCVKM..LANGSGNGQAITNGVEASTNQDSYGGASVCLYCRAHVEHP....DMDGFCKLRGKYVQVPLG.TL.DPIRFVLENT.VCKVCGCWQANGCTCD......
Q6UZF5_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
F2YDB2_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
R1AB_CVMA5/4326-4447                   .............SNSAILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
A0A0U1WHG4_9ALPC/3932-4053             ............t-NSPLLTMCAFSVDPAKTYLDAVKRGVKPVGNCIKM..LSNGAGTGQAITVGVESNTNQDSYGGASVCLYCRAHVEHP....SMDGRCRLKGKYVQVPLG.TI.DPIRFCLEND.TCKVCMCWLNNGCTCD......
H9BR24_9NIDO/3439-3558                 ............q-NASLLTYLAFAADPKDAYLKHVQAGGKPLMGAVKM..VAP-IGEGFAVTTKPQPNANQHSYGGASICVYCRAHVPHN....TVNGQCLYKGRFVQIDKD.-L.DPFKFLLEHQ.PCTSCQRWQSHDCTC-g.....
A0A0F6PN25_9NIDO/2989-3094             payfslvvkrllm---------------------------VPVLEAVRLggLAN-CEEHYAISSVPVRTNGFITYVGESICDDCRSKKDH-....----ECQYKGKFVQLPAG.KQlKDVKLCKHNKfECKVCAKLQS------vqvqsk
R1A_BCHK9/4103-4225                    .............SNSSILSLCSFSVDPEATYKDYLDNGGSPIGNCVKM..LTPHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHP....GASGVCKYKGKFVQIPLVgVN.DPIGFCIRNV.VCAVCNMWQGYGCPC-s.....
F2YDB1_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
A0A1X9JQL5_9ALPC/3829-3950             ...........td--CQILTLCAFAVNPKDAYLTAVKQGHKPLSNCIKM..INNGSGNGLAITPRVEANTVQDSYGGASCCLYCRASVEHP....SMNGVCNLRGKYVQVPTG.TT.DPVRFVLENE.VCSVCSCWLGHGCVCD......
A0A0U1UZ65_BCHK4/4298-4419             .............SNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKM..LAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHP....DVSGVCKYKTRFVQIPAH.VR.DPVGFLLKNV.QCNVCQYWVGYGCNCD......
R1AB_CVPPU/3872-3993                   .............SNSSLLTLCAFSPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQIPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
A3EXI9_BCHK9/4098-4220                 ............g-NSSILSLCSFSVDPEATYKDYLDNGGSPIGNCVKM..LTPHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHP....GASGVCKYKGKFVQVPLVgVN.DPIGFCIKNV.VCAVCNMWQGYGCPC-s.....
H9TEW9_9ALPC/3873-3994                 .............SNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKM..LSNGAGNGMAITNGVEANTQQDSYGGASVCIYCRCHVEHP....AIDGLCRYKGKFVQIPTG.TQ.DPIRFCIENE.VCVVCGCWFNNGCMCD......
A0A0U1WHK4_SARS/4239-4361              .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
Q9J3E9_9BETC/4325-4446                 ............c-NSAILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
R1AB_BCHK9/4103-4225                   .............SNSSILSLCSFSVDPEATYKDYLDNGGSPIGNCVKM..LTPHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHP....GASGVCKYKGKFVQIPLVgVN.DPIGFCIRNV.VCAVCNMWQGYGCPC-s.....
A0A0U1WHG0_SARS/4234-4356              .............ANSTVLSFCAFAVDPAKAYKDYLSSGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
H9BR16_9NIDO/3475-3594                 .............ENNSLLTYLAFAVNPREAYLAHISNGGKPIQGAVRV..IAP-QGEGFAVTTKPQPNAMQHAYGGASICLYCRAHVTHP....SMDGRCNYKGRFVHIDKD.-L.EPTQFALTHE.PCTACHRWVNHDCTC-t.....
H9BQZ9_9NIDO/3506-3625                 ............q-NASLLTYLAFAVDPKAAYLKHLADGGSPIQGCIQM..IAT-MGPGFAVTTKPQPNEHQYSYGGASICLYCRAHIPHP....GVDGRCPYKGRFVHIDKD.-R.EPVSFALTHE.PCSSCQRWVNHDCTC-g.....
U5LR11_9BETC/4309-4431                 .............SNSSVLSLVNFAVDPAKAYTDYVNAGGAPLTNCVKM..LTPKTGTGIAISVKPESNLDQETYGGASVCLYCRAHIEHP....DVSGVCKFKGKFVQIPAQcTR.DPVGFCLANV.QCNVCQYWVGYGCNCD......
A3EXA2_BCHK4/4290-4411                 .............SNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKM..LAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHP....DVSGVCKYKTRFVQIPAH.VR.DPVGFLLKNV.PCNVCQYWVGYGCNCD......
H9BR34_9NIDO/3399-3518                 .............ENASLLTYLAFAVNPKEAYLKHVADGGKPIQGVIQM..IAP-IGSGFAVTTKPQPNEMQYSYGGASVCLYCRAHITHP....GVDGRCVYKGRFVHIDKD.-K.EPVSFALTHE.PCNSCQRWLNYDCTC-g.....
R1A_BCHK4/4290-4411                    .............SNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKM..LAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHP....DVSGVCKYKTRFVQIPAH.VR.DPVGFLLKNV.PCNVCQYWVGYGCNCD......
R1A_CVM2/4274-4395                     .............SNSAIRSLCAFSVDPKKTYLDYIQQGGAPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
H9BZX5_9BETC/4329-4450                 .............SNSAILSLCAFSVDPKKTYLDYIQQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCAFWRDGSCSC-v.....
R1A_CVMJH/4332-4453                    .............SNSAILSLCAFSVDPKKTYLDYIQQGGVPVTNCVKM..LCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP....DVDGLCKLRGKFVQVPLG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
A0A1B3Q5W8_9BETC/4145-4267             .............SNSAILSLCAFSVDPEATYKDYLDNGGTPIGNCVKM..LTTHTGTGLALTAKPDASIDQESFGGASCCIYCRCHIEHP....GASGVCKFKGKFVQIPLCgVP.DPVGFCIRNV.ICSVCNMWQGYGCPC-a.....
S5Z1D1_9ALPC/4016-4137                 ............m-NSSLLTMCAFSTDPAKTYLDAVKSGVKPIGNCVKM..LANGAGNGQAITNGVEANTSQDSYGGASVCLWCRAYVEHP....AMDGFCKYRGKYVQVPIG.TV.DPIRYCLENE.VCKVCGCWLNNGCSCD......
H9BR07_9NIDO/3484-3603                 .............ENASLLTYLAFAVDPKAAYLKHLAEGGKPIQGCVQM..IAA-MGPGFAVTIKPQPNEHQNSYGGASICLYCRAHIPHP....GVDGRCPYKGRFVQIDKD.-K.EPVSFALTHE.PCSSCQRWVAYDCTC-g.....
B7U2M9_9BETC/4241-4362                 .............SNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKM..LCDHAGTGMAITVKPDATTSQDSYGGASVCIYCRARVEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYVLTHD.VCQVCGFWRDGSCSC-v.....
V5TFR4_9GAMC/3767-3888                 .............ENCGILSLCSFALDAKECYLEYIKEGGTPLSNCVKM..LTLHTGSGAAVTVKPAPTPEQDSFGGASVCLYCRAHISHP....GVYGVCQFKGKFVQIPVE.EK.DPVGFCLRNK.ICTVCQMWIGFGCQCD......
E0XIZ2_9BETC/4230-4352                 .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVIPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcTN.DPVGFILRNT.VCTVCGMWKGYGCSCD......
B8Q8S5_SARS/4239-4361                  .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYVQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
H9AA60_9BETC/4262-4383                 .............SNSSILSLCAFSVDPKKTYLDFIQQGGAPISNCVKM..LCDHAGTGMAITVKPEATTSQDSYGGASVCIYCRARIEHP....DVDGLCKLRGKFVQVPVG.IK.DPVSYILTHD.VCQVCGFWRDGSCSC-v.....
A0A0K1YZY7_SARS/4239-4361              .............ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM..LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP....NPKGFCDLKGKYIQIPTTcAN.DPVGFTLRNT.VCTVCGMWKGYGCSCD......
A0A125R5A3_9ALPC/3884-4005             .............SNSGLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKM..LSNGAGNGMAITNGVESNTQQDSYGGASVCIYCRCHVEHP....AIDGLCRFKGKFVQVPTG.TQ.DPIRFCIENE.VCVVCGCWLNNGCMCD......
U5KNA9_9BETC/4309-4431                 .............SNSSVLSLVNFAVDPAKAYTDYVNAGGAPLTNCVKM..LTPKTGTGIAISVKPESNLDQETYGGASVCLYCRAHIEHP....DVSGVCKFKGKFVQIPAQcTR.DPVGFCLANV.QCNVCQYWVGYGCNCD......
#=GC SS_cons                           .............CHHHHHHHHHCCSSHHHHHHHHHHTT--------BE..E-SSBS-S-SEESS--BBTTEEEEECGGG-HHHHHT---S....SSSSS-SSTTSEEEEEGGGTT.SHHHHHHHSE.BETTTSSBTTTBESTT......
#=GC seq_cons                          .............uNSolLolCAFAVDPtKsYlDalppGGpPlsNCVKM..LsstsGTGhAITspPEANssQDSYGGASVCLYCRuHl-HP....sscGhCchKGKaVQlPhs.sp.DPVuFsLcNs.VCsVCshWhshGCsCD......
//
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