GenomeNet

Database: Pfam
Entry: CoV_NSP15_C
LinkDB: CoV_NSP15_C
Original site: CoV_NSP15_C 
#=GF ID   CoV_NSP15_C
#=GF AC   PF19215.2
#=GF DE   Coronavirus replicase NSP15, uridylate-specific endoribonuclease
#=GF PI   Corona_NSP15_C;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Manual
#=GF GA   23.90 23.90;
#=GF TC   24.30 23.90;
#=GF NC   23.30 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0695
#=GF RN   [1]
#=GF RM   16873248
#=GF RT   New antiviral target revealed by the hexameric structure of
#=GF RT   mouse hepatitis virus nonstructural protein nsp15.
#=GF RA   Xu X, Zhai Y, Sun F, Lou Z, Su D, Xu Y, Zhang R, Joachimiak A,
#=GF RA   Zhang XC, Bartlam M, Rao Z;
#=GF RL   J Virol. 2006;80:7909-7917.
#=GF RN   [2]
#=GF RM   29307596
#=GF RT   An "Old" protein with a new story: Coronavirus endoribonuclease
#=GF RT   is important for  evading host antiviral defenses.
#=GF RA   Deng X, Baker SC;
#=GF RL   Virology. 2018;517:157-163.
#=GF RN   [3]
#=GF RM   32198201
#=GF RT   Coronavirus endoribonuclease targets viral polyuridine sequences
#=GF RT   to evade activating host sensors.
#=GF RA   Hackbart M, Deng X, Baker SC;
#=GF RL   Proc Natl Acad Sci U S A. 2020 Mar 20. pii: 1921; [Epub ahead of print]
#=GF DR   INTERPRO; IPR043609;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the C-terminal domain of coronavirus
#=GF CC   non-structural protein 15 (NSP15 or nsp15). NSP15 is encoded by
#=GF CC   ORF1a/1ab and proteolytically released from the pp1a/1ab
#=GF CC   polyprotein. This domain exhibits endoribonuclease activity
#=GF CC   designated EndoU, highly conserved in all known CoVs and is part
#=GF CC   of the replicase-transcriptase complex that plays important
#=GF CC   roles in virus replication and transcription [1, 2, 3]. NSP15 is
#=GF CC   a Uridylate-specific endoribonuclease that cleaves the
#=GF CC   5'-polyuridines from negative-sense viral RNA, termed PUN RNA
#=GF CC   either upstream or downstream of uridylates, at GUU or GU to
#=GF CC   produce molecules with 2',3'-cyclic phosphate ends [2, 3]. PUN
#=GF CC   RNA is a CoV MDA5-dependent pathogen-associated molecular
#=GF CC   pattern (PAMP) [3].
#=GF SQ   98
#=GS B1PHK0_9ALPC/6440-6594      AC B1PHK0.1
#=GS S5YAF0_9ALPC/6369-6523      AC S5YAF0.1
#=GS R1AB_FIPV/6253-6407         AC Q98VG9.2
#=GS A0A0U2LWJ9_9ALPC/2224-2378  AC A0A0U2LWJ9.1
#=GS H9BR07_9NIDO/5823-5972      AC H9BR07.1
#=GS A0A1B3Q5W8_9BETC/6527-6678  AC A0A1B3Q5W8.1
#=GS R1AB_CVHOC/6641-6794        AC P0C6X6.1
#=GS R1AB_SARS2/6643-6796        AC P0DTD1.1
#=GS R1AB_SARS2/6643-6796        DR PDB; 6XDH A; 192-345;
#=GS R1AB_SARS2/6643-6796        DR PDB; 6W01 B; 192-345;
#=GS R1AB_SARS2/6643-6796        DR PDB; 6VWW B; 192-345;
#=GS R1AB_SARS2/6643-6796        DR PDB; 6XDH B; 192-345;
#=GS R1AB_SARS2/6643-6796        DR PDB; 6W01 A; 192-345;
#=GS R1AB_SARS2/6643-6796        DR PDB; 6VWW A; 192-345;
#=GS A0A096XNJ3_9ALPC/6293-6446  AC A0A096XNJ3.2
#=GS A0A0P0LKV0_CVH22/6307-6461  AC A0A0P0LKV0.1
#=GS R1AB_WBV24/6471-6602        AC Q008X6.1
#=GS A0A0U1WHG4_9ALPC/6284-6438  AC A0A0U1WHG4.1
#=GS B8Q8S4_SARS/6620-6773       AC B8Q8S4.1
#=GS A0A240FW17_9ALPC/5873-6027  AC A0A240FW17.1
#=GS H9BZX5_9BETC/6725-6878      AC H9BZX5.1
#=GS B1PHJ3_9ALPC/6476-6630      AC B1PHJ3.1
#=GS A0A0F6PU04_9NIDO/1187-1306  AC A0A0F6PU04.1
#=GS H9TEX0_9ALPC/6229-6383      AC H9TEX0.1
#=GS V5TFR4_9GAMC/6193-6349      AC V5TFR4.1
#=GS Q0ZJB1_CVHK1/6727-6880      AC Q0ZJB1.1
#=GS H9AA60_9BETC/6658-6811      AC H9AA60.1
#=GS A0A1X9JPE2_9ALPC/2214-2367  AC A0A1X9JPE2.1
#=GS R1AB_SARS/6620-6773         AC P0C6X7.1
#=GS R1AB_SARS/6620-6773         DR PDB; 2RHB D; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2H85 A; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2RHB E; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2RHB C; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2RHB B; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2RHB A; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2OZK A; 191-332;
#=GS R1AB_SARS/6620-6773         DR PDB; 2OZK B; 191-332;
#=GS R1AB_SARS/6620-6773         DR PDB; 2RHB F; 191-344;
#=GS R1AB_SARS/6620-6773         DR PDB; 2OZK D; 191-332;
#=GS R1AB_SARS/6620-6773         DR PDB; 2OZK C; 191-332;
#=GS RPOA_EAVBU/2941-3055        AC P19811.3
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5F17 F; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HC1 D; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5F17 D; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5F17 E; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HC1 C; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HC1 A; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HC1 B; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5F17 B; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5F17 C; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HBZ B; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5F17 A; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HBZ D; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HBZ E; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HBZ F; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HBZ C; 104-218;
#=GS RPOA_EAVBU/2941-3055        DR PDB; 5HBZ A; 104-218;
#=GS A0A0B6C113_9NIDO/3286-3400  AC A0A0B6C113.1
#=GS A0A0U1UZA8_9ALPC/6475-6629  AC A0A0U1UZA8.1
#=GS A3EXI9_BCHK9/6475-6626      AC A3EXI9.1
#=GS A0A0U1UZ65_BCHK4/6670-6823  AC A0A0U1UZ65.1
#=GS A0A0U1WHD1_9ALPC/6433-6587  AC A0A0U1WHD1.1
#=GS H9BR34_9NIDO/5778-5927      AC H9BR34.1
#=GS Q0PL13_9ALPC/2224-2378      AC Q0PL13.1
#=GS U5KNA9_9BETC/6684-6837      AC U5KNA9.1
#=GS A0A0U1UZ20_9ALPC/6440-6594  AC A0A0U1UZ20.1
#=GS RPOA_PRRSB/3677-3805        AC Q8B912.3
#=GS R1AB_BEV/6455-6592          AC P0C6V7.1
#=GS A0A0E3J9G4_9NIDO/1882-2014  AC A0A0E3J9G4.1
#=GS A0A0K1RM35_9ALPC/2224-2378  AC A0A0K1RM35.1
#=GS R1AB_CVH22/6302-6456        AC P0C6X1.1
#=GS R1AB_CVH22/6302-6456        DR PDB; 4RS4 A; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4RS4 F; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4RS4 C; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4S1T E; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4RS4 E; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4S1T B; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4RS4 B; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4S1T A; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4S1T D; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4S1T F; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4RS4 D; 192-346;
#=GS R1AB_CVH22/6302-6456        DR PDB; 4S1T C; 192-346;
#=GS H9BR16_9NIDO/5848-5998      AC H9BR16.1
#=GS R1AB_BRV1/6335-6468         AC P0C6V8.1
#=GS A0A6B9PEE1_9NIDO/1145-1259  AC A0A6B9PEE1.1
#=GS B6VDX7_THCOV/5856-6005      AC B6VDX7.1
#=GS A0A0F6WGL5_9GAMC/6214-6369  AC A0A0F6WGL5.1
#=GS A0A1Z2RX77_9NIDO/3195-3312  AC A0A1Z2RX77.1
#=GS B7U2N0_9BETC/2263-2416      AC B7U2N0.1
#=GS A0A076PY83_9NIDO/7705-7821  AC A0A076PY83.1
#=GS R1AB_BC512/6336-6490        AC P0C6W0.1
#=GS R1AB_IBVB/6170-6325         AC P0C6Y1.1
#=GS A0A159D6T4_9NIDO/1196-1307  AC A0A159D6T4.1
#=GS A0A2H4MWN4_9NIDO/3630-3750  AC A0A2H4MWN4.1
#=GS H9BQZ9_9NIDO/5847-5996      AC H9BQZ9.1
#=GS R1AB_CVPPU/6228-6382        AC P0C6Y5.1
#=GS K4K1U5_9ALPC/6323-6477      AC K4K1U5.1
#=GS RPOA_SHFV/3297-3417         AC Q68772.4
#=GS A0A0U1UZC3_9ALPC/6206-6360  AC A0A0U1UZC3.1
#=GS A0A0E3GHV1_9NIDO/6613-6745  AC A0A0E3GHV1.1
#=GS C0KYZ7_9BETC/2279-2432      AC C0KYZ7.1
#=GS R1AB_BCHK5/6719-6872        AC P0C6W4.1
#=GS I6LMN0_9NIDO/6785-6906      AC I6LMN0.1
#=GS A0A0U1WHG0_SARS/6615-6768   AC A0A0U1WHG0.1
#=GS B2BW31_9GAMC/6193-6349      AC B2BW31.1
#=GS F2YDB1_SARS/6620-6773       AC F2YDB1.1
#=GS B1PHI6_9ALPC/6532-6686      AC B1PHI6.1
#=GS R1AB_BCHK9/6480-6631        AC P0C6W5.1
#=GS A0A140ESF0_9NIDO/5837-5986  AC A0A140ESF0.1
#=GS D9J202_9ALPC/6215-6369      AC D9J202.1
#=GS A0A023YA54_MERS/6721-6874   AC A0A023YA54.1
#=GS A0A125R5A3_9ALPC/6240-6394  AC A0A125R5A3.1
#=GS A3EXE7_BCHK5/6716-6869      AC A3EXE7.1
#=GS R1AB_CVMA5/6722-6875        AC P0C6X9.1
#=GS A0A088DIE1_9BETC/6793-6946  AC A0A088DIE1.1
#=GS Q06BE0_9BETC/2188-2341      AC Q06BE0.1
#=GS A0A0K1YZY7_SARS/6620-6773   AC A0A0K1YZY7.1
#=GS E0ZN59_BCHK9/6455-6606      AC E0ZN59.1
#=GS A3EXC0_BCHK4/6672-6825      AC A3EXC0.1
#=GS T2B9U0_MERS/6620-6773       AC T2B9U0.1
#=GS R1AB_CVM2/6670-6823         AC P0C6X8.1
#=GS A0A0Y0BX48_9NIDO/3254-3366  AC A0A0Y0BX48.1
#=GS A0A089FYB2_9NIDO/3255-3367  AC A0A089FYB2.1
#=GS E0XIZ2_9BETC/6611-6764      AC E0XIZ2.1
#=GS A0A1L3KIY4_9NIDO/7027-7151  AC A0A1L3KIY4.1
#=GS H9BR24_9NIDO/5778-5927      AC H9BR24.1
#=GS A0A0K2RW65_9BETC/6663-6816  AC A0A0K2RW65.1
#=GS A0A0A7UXR0_9BETC/6684-6837  AC A0A0A7UXR0.1
#=GS A0A0B5JQL5_9NIDO/3468-3570  AC A0A0B5JQL5.1
#=GS R1AB_BC279/6626-6779        AC P0C6V9.1
#=GS B7SCK8_EAV/2941-3055        AC B7SCK8.1
#=GS A3EXA2_BCHK4/6662-6815      AC A3EXA2.1
#=GS A0A0U1WHG1_9ALPC/6141-6295  AC A0A0U1WHG1.1
#=GS Q6UZF5_SARS/6620-6773       AC Q6UZF5.1
#=GS R9QTA1_SARS/2175-2328       AC R9QTA1.1
#=GS Q9J3E8_9BETC/2279-2432      AC Q9J3E8.1
#=GS Q9J3E8_9BETC/2279-2432      DR PDB; 2GTH A; 219-369;
#=GS Q9J3E8_9BETC/2279-2432      DR PDB; 2GTI A; 219-369;
#=GS B8Q8U6_SARS/6620-6773       AC B8Q8U6.1
#=GS E0ZN51_BCHK9/6475-6626      AC E0ZN51.1
#=GS A8JNZ0_9ALPC/6271-6425      AC A8JNZ0.1
#=GS A0A0U1WHK4_SARS/6620-6773   AC A0A0U1WHK4.1
#=GS R1AB_BCHK4/6662-6815        AC P0C6W3.1
#=GS R1AB_CVMJH/6726-6879        AC P0C6Y0.1
B1PHK0_9ALPC/6440-6594                 ..................................d-SIFTQGRSAEN.FVPRTQMETDFLELDMGLFISKYGLE.NF.AF...E..HIVYGDVSKT..TLGGLHLLISQVRLSKMGILKVEEFVHTgDSSL......RCASVT..YVDNPSSKMVC.SYMDILLD...DFVTLLKTLDLSV...VSKVHEVIVDCKVYRWMLWCK.DHKVQTFYPQ......
S5YAF0_9ALPC/6369-6523                 ..................................e-GFYTQGRTSAD.FKPRSTMEEDFLNMDTGLFISKYGLE.DY.AF...E..HVVYGDISKT..TLGGLHLLISQVRLSKLGILKIDEFIAAgDSTL......KSCTVT..FADNPSSKSVC.TYMDLLLD...DFVTIMKSLDLSV...VSKVHEVMVDCKMWRWMLWCK.DHKVQTFYPQ......
R1AB_FIPV/6253-6407                    ..................................d-SYYTHGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLAKMGLFSVQEFMTNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIIKSLDLNV...VSKVVDVIVDCKAWRWMLWCE.NSQIKTFYPQ......
A0A0U2LWJ9_9ALPC/2224-2378             ..................................d-SYYTQGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLAKMGLFSVQEFINNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIIKSLDLNV...VSKVVDVIVDCKAWRWMLWCE.NAHIKTFYPQ......
H9BR07_9NIDO/5823-5972                 ...................................DTICTQGRSVDK.FIPKTPMEKDFLEKPADEFISLYQLQ.DL.GV...E..HIIYGDDATP..IIGGTHTLISLVRNK----FDYQLVNHI.YNPV......QNCVVT..-SPNASSKNVC.TILDVLLD...DYIDIIRQAHATYt.tRSKVFSVVIDNQQVHFMLWH-.DAKVNTCYP-i.....
A0A1B3Q5W8_9BETC/6527-6678             ...................................DTLFTQSRTLDD.FEPRSEMETDFLNLSQQDFLVKYDLE.GY.GL...E..HIAYGQFE-S..VIGGLHLLIGVVLRKKVSDIRLESVLGN.-DTV......TSYAVV..DKPTAANKQVC.SVFDVLLD...DFVALLKEQDRTV...VSKVVQVTLDFKVYRFMLWCK.DGQIATFYPQ......
R1AB_CVHOC/6641-6794                   ..................................s-TIFTQSRVISS.FTCRTDMEKDFIALDQDVFIQKYGLE.DY.AF...E..HIVYGNFNQK..IIGGLHLLIGLYRRQQTSNLVVQEFVSY.DSSI......HSYFIT..DEKSGGSKSVC.TVIDILLD...DFVTLVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.DEKVMTFYPR......
R1AB_SARS2/6643-6796                   ..................................e-TYFTQSRNLQE.FKPRSQMEIDFLELAMDEFIERYKLE.GY.AF...E..HIVYGDFSHS..QLGGLHLLIGLAKRFKESPFELEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...VSKVVKVTIDYTEISFMLWCK.DGHVETFYPK......
#=GR R1AB_SARS2/6643-6796        SS    ..................................---B------STT.----SHHHHHHHHS-HHHHHHHTT-T.TS.-H...H..HHTT-B-SSS..B-B---BHHHHHHHHHHS-EEEE-SS-S.--SS......EEEEEE..ETTT--EEEEE.EEB---HH...HHHHHHCTS-TSS...SEEEEEEEETTEEEEEEEEEE.TTEEEEEEE-......
A0A096XNJ3_9ALPC/6293-6446             ..................................d-GFYSQGRTVST.FKPRSTMESDFLELDTDLFINKYGLQ.DY.GF...E..HVVYGDFSKS..TIGGLHLLISQIRLARIGYLKIDDFGGNsDSTV......KCCSVT..-CIENSSKVVC.SYVDLLLD...DFVTILKSLDLSV...VSKVHDVVIDGKPWRWMLWCK.DNKVSTFYPQ......
A0A0P0LKV0_CVH22/6307-6461             ..................................d-GYYTQGRNLQD.FLPRSTMEEDFLNMDTGVFIQKYGLE.DF.NF...E..HVVYGDVSKT..TLGGLHLLISQVRLGKMGILKAEEFAAAsDVTL......KCCTVT..YLNDPSSKAVC.TYMDLLLD...DFVAILKSLDLSV...VSKVHEVIIDNKPWRWMLWCK.DNAVATFYPQ......
R1AB_WBV24/6471-6602                   ..............................tstnr------------.-------------LTTKQFIYTPNED.EY.KSklgH..HVSVGDTSNVswTIGGMHVLTAF-----QNITNYQLVSGP.ANPI......MRINVA..--LERGNKVET.TALDTTLQ...DYYKIATTNKV-T...VSKTTFFTLDGGQYRMMNFANpDGTIQTSYPV......
A0A0U1WHG4_9ALPC/6284-6438             ..................................d-GYYTQGRNVSE.FLPRSDMEKDFLEMDMSVFISKYGLE.DY.AF...E..HVVYGDVSKT..TLGGLHLLISQVRLQKLGVLKIEDFTSSdDGTL......KCCTVT..FANDPSSKMVC.TYMDLLLD...DFVLILKNLDLSV...VSKVQEVIVDCKMWRWMLWCK.DHKVQTFYPQ......
B8Q8S4_SARS/6620-6773                  ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
A0A240FW17_9ALPC/5873-6027             ..................................c-SFFTQGRTFDT.FVPRSEMEKNFLNMETQDFIVKYGLE.DF.GF...E..HVVYGDVSKN..VVGGLHLLISQVRLSKMGVLKCEHFGGSvLNTI......NCCSVI..YLDNPSYKHVC.TYMDMLLD...DFVVILKSQDLSV...VSKVVNINVDLKNFRFMLWCK.DKKVSTFYP-t.....
H9BZX5_9BETC/6725-6878                 ..................................g-TIFTQSRLLSS.FTPRSEMEKDFMDLDDAVFIAKYSLQ.DY.AF...E..HVVYGSFNQK..IIGGLHLLIGLARRQRKSNLVIQEFVPY.DSSI......QSYFIT..DENSGSSKSVC.TVIDLLLD...DFVDIVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
B1PHJ3_9ALPC/6476-6630                 ..................................d-GIFTQGRNVSI.FEPRSEMESDFLNLDMGLFISKYGLE.DY.AF...E..HIVFGDVSKN..TLGGLHLLISQVRLSKMGVLKVEDFVSSaDSTL......KSCSVT..YVNDPSSKMVC.TYMDILLD...DFVNVLKSLDLSV...VSKVHEVIVDCKVYRWMLWCK.DYKVQTFYPQ......
A0A0F6PU04_9NIDO/1187-1306             .......................slfstgrialdc------------.----------------RNYLSKEEREfAL.KH...A..HAFIGEVKGQ..TVGGCHHITSCYLPPE---IPSGDVVK-.----......--IGVS..-APGRAKKALC.TLTDV---...-YLPLLEQYANPP..tASKCYSVSVDCRPVRLMVWKD.----------atmyf.
H9TEX0_9ALPC/6229-6383                 ..................................d-SYYTQGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLAKMGLFSVQEFMTNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIIKSLDLNV...VSKVVDVIVDCKAWRWMLWCE.NSQIKTFYPQ......
V5TFR4_9GAMC/6193-6349                 ..................................s-QLFTEQRSFED.FFPLSVMERDFLNMEAPQFIAKYDCK.GL.GL...E..HVLYGDFSKK..VIGGAHLTIGLARLYTQEKFDVHEISPSsFDVF......KSYFVV..-THAGAMKQVC.TVLDVLLD...DFINILKEIKVSHkgvVSEVLHYVVDYQTVDFMLWMG.DNAINTFYPK......
Q0ZJB1_CVHK1/6727-6880                 ..................................f-TIFTQSRVLST.FEPRSDLERDFIDMEDSLFIAKYGLE.DY.AF...D..HIVYGSFNYK..VIGGLHLLIGLFRRLKKSNLVIQEFLQY.DSSI......HSYFIT..DQECGSSKSVC.TVIDLLLD...DFVVIVKSLNLNC...VSKVVNINVDFKDFQFMLWCN.DNKIMTFYPK......
H9AA60_9BETC/6658-6811                 ..................................v-TIFTQSRVISS.FECRSDMEKDFIALDEEMFIQKYGLE.DY.AF...D..HIVYGSFNQK..IIGGLHLLIGLFRRHQKSNLVVQEFVSY.DSSI......HSYFIT..DEKSGSSKSVC.TVVDILLD...DFVAFVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
A0A1X9JPE2_9ALPC/2214-2367             ..................................d-GFYSQGRTVTT.FKPRSTMEIDFLELDTDIFINKYGLQ.EY.GF...E..HVVYGDFSKT..TIGGLHLLISQIRLARIGYLKVEDFGGNsDSTI......KCCSVT..YIEN-SSKVVC.SYVDLLLD...VFVTILKGLDLSV...VSKVYEVVIDGKPWRWMLWCK.DNKVATFYPQ......
R1AB_SARS/6620-6773                    ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
#=GR R1AB_SARS/6620-6773         SS    ..................................---B------STT.----SHHHHHHHHS-HHHHHHHTT-T.TS.SH...H..HHTSSB-SSS..BSB-EEBHHHHHHHHTTS-EEEEESSSS.--SS......EEEEEE..ETTT--EEEEE.EEB---HH...HHHHHHHTS-TSS...SEEEEEEEETTEEEEEEEEEE.TTEEEEEEEX......
RPOA_EAVBU/2941-3055                   ................rfetnsrafldeaeekfaa------------.--------------------------.--.AH...P..HACLGEINKS..TVGGSHFIFSQYLPP---------LLPAdAVAL......VGAS--..-LAGKAAKAAC.SVVDVYAP...SFEPYLHPETL--...-SRVYKIMIDFKPCRLMVWRN.----------atfyvq
#=GR RPOA_EAVBU/2941-3055        SS    ................HHHHT--S-SSHHHHHHHH------------.--------------------------.--.HS...T..THHTEEESSS..SEETEEETT-TTS-S------------TSSEEE......EEEE--..-ETTTEEEEEE.EEE-B-GG...GGGGGSS-SSS--...-EEEEEEEETTEEEEEEEETT.----------TEEEEE
A0A0B6C113_9NIDO/3286-3400             .................ridldirsyldeeerdfa------------.--------------------------.-I.AH...P..HAFIGDTKGT..TVGGCHHITSRYL---------PKVIPS.DSVV......K-VGVS..-APGKAHKACC.TLTDV---...-YLPYLREFDSPP..tQSKVYKVRIDNKECRLMVWRD.Q---------tmyfq.
A0A0U1UZA8_9ALPC/6475-6629             ..................................d-GIFTQGRNVSI.FEPRSEMESDFLNLDMGLFISKYGLE.DY.AF...E..HIVFGDVSKN..TLGGLHLLISQVRLSKMGVLKVEDFVSSaDSTL......KSCSVT..YVNDPSSKMVC.TYMDILLD...DFVNVLKSLDLSV...VSKVHEVIVDCKVYRWMLWCK.DYKVQTFYPQ......
A3EXI9_BCHK9/6475-6626                 ..................................d-GYFTQSRTLDD.FQPRTQLELDFLDLEQSCFLDKYDLH.DL.GL...E..HIAYGQFE-G..TIGGLHLLIGAVRRKRTANLVMETVLGT.-DTV......TSYAVI..DQPTASSKQVC.SVFDMILD...DFIELIKAQDRSV...VSKVVQCCLDFKVFRFMLWCK.DGKVATFYPQ......
A0A0U1UZ65_BCHK4/6670-6823             ...................................DTFYTCGRTVGD.FIALTPMEEDFLVLDSDVFIRKYSLE.DY.AF...E..HVVYGDFSHT..TLGGLHLLIGLYRKMRDGHILMEEMLKD.RATV......HNYFIT..DSNTASYKAVC.SVVDLKLD...DFVNIIKEMDLDV...VSKVVKVPIDLTMIEFMLWCK.DGKVQTFYPR......
A0A0U1WHD1_9ALPC/6433-6587             ..................................d-GIFTQGRSANN.FVPRTQMESDFLELDMGLFISKYGLE.NF.AF...E..HIVYGDVSKT..TLGGLHLLISQVRLSKMGILKVEEFVHTgDSSL......RCASVT..YVDNPSSKMVC.SYMDILLD...DFVTLLKTLDLSV...VSKVHEVIVDCKVYRWMLWCK.DHKVQTFYPQ......
H9BR34_9NIDO/5778-5927                 ...................................DTICTQGRLLDK.FTPRSKMESDFLTMDQSTFIDTYKLQ.DL.GI...D..HIIYGDDTKP..IIGGTHTFISLVRNK----FNCQMVSHI.YNPV......QNCVVT..-STSASTKEVC.TVLDILLD...DYVDIIRNAHNNYt.tKSKVFSVTIDNQKVSFMLWH-.DANVQTCYP-i.....
Q0PL13_9ALPC/2224-2378                 ..................................d-SYYTQGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLAKMGLFSVQEFMNNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIIKSLDLNV...MSKVVDVIVDCKAWRWMLWCE.NSHIKTFYPQ......
U5KNA9_9BETC/6684-6837                 ..................................d-SIYTQGRSCSD.FEPCTQMEKDFLSMESNVFIKKYNLE.DY.AF...E..HVVYGDFSHT..TLGGLHLLIGLYKKSLEGHIIMEEMLKE.SATI......HNYFIT..ETNTASFKAVC.SVIDLTLD...DFVQLLKSLDLGV...VSKVVKIPIDLMFVEFMLWCK.EGQVQTFYPR......
A0A0U1UZ20_9ALPC/6440-6594             ..................................d-SIFTQGRSAEN.FVPRTQMETDFLELDMGLFISKYGLE.NF.AF...E..HIVYGDVSKT..TLGGLHLLISQVRLSKMGILKVEEFVHTgDSSL......RCASVT..YVDNPSSKMVC.SYMDILLD...DFVTLLKTLDLSV...VSKVHEVIVDCKVYRWMLWCK.DRKVQTFYPQ......
RPOA_PRRSB/3677-3805                   rgeaqvlpetvfstgrievdcreylddrerevaes------------.--------------------------.--.-L...P..HAFIGDVKGT..TVGGCHHVTSKYL---------PRFLPK.-ESV......AVVGVS..-SPGEAAKAFC.TLTDVYLP...DLEAYLHPE---T...QSKCWKVMLDFKEVRLMVWKG.----------ktayf.
R1AB_BEV/6455-6592                     ................lfstgrlynldhdaaqnfn------------.-------------------VKQLAIE.TMpNN...H..HVFSGDFTEVgtDIGGVHHVVALNG--YKGSIIPNY----.VKPI......ATGLIN..--VGRAVKR-T.TLVDVCAN...QLYEKVKQQLEGV..kVSKVIFVNIDFQDVQFMVFANgEDDIQTFYPQ......
A0A0E3J9G4_9NIDO/1882-2014             ..................................i-GLFSTNRLFTNqYVPLPNEQQAY--------------E.DF.G-...K..HVSLGETTATswTIGGMHLLPAF--QTTTNWQITSEHTPI.----......--LSIT..IARDRGVKLGT.TALDVPAD...QLLELIDYKNI-I...VSKVIAIKIDGQKVNMMVFTQ.NGKIQTAYPV......
A0A0K1RM35_9ALPC/2224-2378             ..................................d-SYYTQGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLAKMGLFSVQEFMNNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIIKSLDLNV...VSKVVDVIVDCKAWRWMLWCE.NSHIKTFYPQ......
R1AB_CVH22/6302-6456                   ..................................d-GFYTQGRNLQD.FLPRSTMEEDFLNMDIGVFIQKYGLE.DF.NF...E..HVVYGDVSKT..TLGGLHLLISQVRLSKMGILKAEEFVAAsDITL......KCCTVT..YLNDPSSKTVC.TYMDLLLD...DFVSVLKSLDLTV...VSKVHEVIIDNKPWRWMLWCK.DNAVATFYPQ......
#=GR R1AB_CVH22/6302-6456        SS    ..................................--SB-B----TTT.----SHHHHHHHHS-HHHHHHHHT-T.TT.TH...H..HHTS-BTSSS..B-B---BHHHHHHHHHHS-EEEEESS--SS-SS......EEEEEE..ETTTTEEEEEE.EEB-B-HH...HHHHHHTTS-TTS...SEEEEEEEETTEEEEEEEEEE.TTEEEEEEE-......
H9BR16_9NIDO/5848-5998                 ...................................DTLYSQQRSVVN.FKPLTKMEADFLSMTQDQFIQTYDLT.NL.GV...E..HILYGDTSKT..ILGGCHALISLVHSEFSSDFVTHLF---.-NPV......QNMIVT..-ADNGSSKNVC.SVVDLTID...NYIDIIRQAHSVYe.tKSKVFTVVIDNMPIKFTIWHD.SQKVDTLYP-l.....
R1AB_BRV1/6335-6468                    ..................grlynlehdpsknfnvq------------.---------------------QLAIE.TIpKN...H..HVFAGDFTDVgtDIGGVHHVVALNG--YKGSIIPNY----.VKPI......ATGLIN..--VGRSVKR-T.TLVDVCAN...QLYEKVKQQIAGV..kVSKVIFVNIDFQEVQFMVFAKgEDDIQTFYPQ......
A0A6B9PEE1_9NIDO/1145-1259             ...............rievdcreylddkeketaes------------.--------------------------.--.-M...P..HAFIGEATGT..TVGGCHHITSKYLPRN---------LPK.-DSV......AVVGVS..-APGRAAKACC.TVTDVYLP...DLADYLTPDT---...ASKVWKINVDFKPSRLMVWKG.----------ktayfq
B6VDX7_THCOV/5856-6005                 ..................................t-TILTQGRVVDK.FIPKTPMEKDFLEMNSEDFINSYELQ.GL.GV...E..HIIYGEDNTP..VIGGTHALISLVRNK----FSFELVNHI.YNPV......QNCVVT..-SQNASSKEVC.TLLDITLD...DYINIIKSAHANFe.tKSKVFSVNIDCQNVKFMLWH-.DEQVQTCYP-i.....
A0A0F6WGL5_9GAMC/6214-6369             ..................................e-TLNTQGRCYET.FEPRSDVEREFLSLSEQDFVAKYG-K.DL.GL...E..HILYGEVDKP..QLGGLHTVIGMYRLLRDNKLSAKSVTDSdCEVM......QNYFVL..-ADNGSYKQVC.TVVDLLLD...DFLDLLRNILQEYgsgKSKVVTVPIDYHNISFMTWFE.NGFIKTCYPQ......
A0A1Z2RX77_9NIDO/3195-3312             ..............stgrllanrrgflsdiereva------------.--------------------------.-F.QN...Y..HPFVGEDHKS..VVGGAHHVTSN-------------FLPE.ELPT......GSVVVVgtSSPGKSAKACT.SVFDVYLP...ELLPYLKPD---T...PSKVYKIHIDCRVYRLMVWKD.-K--------tcyvq.
B7U2N0_9BETC/2263-2416                 ..................................s-TIFTQSRVISS.FTCRTDMEKDFIALDQDVFIQKYGLE.DY.AF...E..HIVYGNFNHK..IIGGLHLLIGLYRRQQTSNLVIQEFVSY.DSSI......HSYFIT..DEKSGGSKSVC.TVIDILLD...DFVALVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.DEKVMTFYPR......
A0A076PY83_9NIDO/7705-7821             ..............................psees------------.--------------------------.-T.EC...A..HIEIGDYNNSslKIGGMHMFPKAFENVSLNNIEQEAS---.-TPL......WHANII..--AKQGTKLHN.SLTDVEIT...RFISCVKDKLTTN..tISTRTSIRIDHQNVPIMIWAT.AGKIDTAYL-q.....
R1AB_BC512/6336-6490                   ..................................d-GYFTQGRVISD.FQPRSNMEEDFLNMDMGLFISKYGLE.DY.GF...E..HVVFGDVSKT..TLGGLHLLISQIRLSKIGVLKVEDFVSSsDSTL......KSCTVT..YVDNPSSKMVC.TYVDLLLD...DFVNILKSVDLSV...VSKVHEVVIDCKVWRWMLWCK.DHKVQTFYPQ......
R1AB_IBVB/6170-6325                    ..................................n-TINTQGRSYET.FEPRSDIERDFLAMSEESFVERYG-K.DL.GL...Q..HILYGEVDKP..QLGGLHTVIGMYRLLRANKLNAKSVTNSdSDVM......QNYFVL..-SDNGSYKQVC.TVVDLLLD...DFLELLRNILKEYgtnKSKVVTVSIDYHSINFMTWFE.DGSIKTCYPQ......
A0A159D6T4_9NIDO/1196-1307             ...................ldcrnyfgkeerefal------------.--------------------------.--.RH...A..HAFIGETKGT..TVGGCHHITSLYLPP---EIPLGDVVKI.----......---GVS..-APGRAKKALC.TLTDV---...-YLPLLEPYTNPP..tASKCYQVNVDCRPVRLMVWKN.S---------tmyfq.
A0A2H4MWN4_9NIDO/3630-3750             .......pqtlfstgrievdcreylddaerqaaer------------.--------------------------.--.-L...P..HAFIGETTGT..TVGGCHHVTSRYLPR---------YLPR.-ESV......SIVGVS..-SPGKAAKALC.SITDVYLP...DLESYLQPE---T...QSKCWKVNLDFKPVRLMVWKN.K---------tay...
H9BQZ9_9NIDO/5847-5996                 ..................................s-TICTQGRNVEQ.FIPKTPMERDFLEMSQESFIDHYQLQ.DL.GV...E..HIIYGDDSSP..VIGGTHTLISLVRNKFE----HQLVNHV.YNPV......QNCVVT..-SSNASSKNVC.TVLDVLLD...DYIDIIRQAHANYt.sKSKVFTVSVDNQQIRFMLWH-.DEQVKTCYP-i.....
R1AB_CVPPU/6228-6382                   ..................................d-SYYTQGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLAKMGLFSVQEFMNNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIIKSLDLNV...VSKVVDVIVDCKAWRWMLWCE.NSHIKTFYPQ......
K4K1U5_9ALPC/6323-6477                 ..................................d-GYYTQGRNIAE.FLPRSDMEKDFLEMDMGMFINKYGLE.DY.AF...E..HVVYGDVSKT..TLGGLHLLISQVRLQKMGVLKIDEFTSSnDGTL......KSCTVT..YANNPSSKMVC.TYMDLLLD...DFVAILKNLDLDV...VSKVQEVIIDCKVWRWMLWCK.GHKVQTFYPQ......
RPOA_SHFV/3297-3417                    ...............svystgrfemdirdyldsae------------.-------------------------R.DF.AA...KhpHAFIGDTKGT..TVGGCHHITSQYL---------PHVLPA.DSVV......K-VGVS..-KPGVAHKALC.TVTDIY--...--LPMLGSYTSPP..tQSKVYKVNVDHKACKLMVWRD.Q---------tmyfq.
A0A0U1UZC3_9ALPC/6206-6360             ..................................d-GYYTQGRNAND.FVARSQMEKDFLAMDTGLFISKYGLE.DY.NF...E..HIVYGDVSKT..TLGGLHLLISQVRLSQIGILKVNDFGGAdDSTL......KCCTVT..YINDPSSKVVC.TYMDLLLD...DFVTILKSLDLSV...VSKVHEVLVDCKIWRWMLWCK.DAHVETFYPQ......
A0A0E3GHV1_9NIDO/6613-6745             ..................................i-GLFSTNRLFTNqYVPLPNEQQAY--------------E.DF.G-...K..HVSLGETTATswTIGGMHLLPAF--QTTTNWQITSEHTPI.----......--LSIT..IARDRGVKLGT.TALDVPAD...QLLELIDYKNI-I...VSKVIAIKIDGQKVNMMVFTQ.NGKIQTAYPV......
C0KYZ7_9BETC/2279-2432                 ..................................g-TIFTQSRFLSS.FSPRSEMEKDFMDLDEDVFIAKYSLQ.DY.AF...E..HVVYGSFNQK..IIGGLHLLIGLARRQKKSNLVIQEFVPY.DSSI......HSYFIT..DENSGSSKSVC.TVIDLLLD...DFVDIVKSLNLKC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
R1AB_BCHK5/6719-6872                   ...................................DTYYTLGRTVSD.FTPVSEMEKDFLALDSDVFIKKYKLE.AY.AF...E..HVVYGDFSRT..TLGGLHLLIGLYKKHQEGHIIMEEMLKE.RATV......HNYFVT..ESNTASFKAVC.SVIDLKLD...DFVDIIKAMDLSV...VSKVVKIPIDLTMIEFMLWCK.DGQVQTFYPR......
I6LMN0_9NIDO/6785-6906                 ........................ftyipneletv------------.-------------------------Q.KL.G-...H..HVTTGDTTEIswTIGGMHTLQSFENL-----TNYQIVSAP.QNPI......IAINVS..--KDRGCKVET.TALDITLQ...DYYTISTQQQV-T...ISRTMVFKLDGGIYRMMVFVNdDGSIQTSYPV......
A0A0U1WHG0_SARS/6615-6768              ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...D..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAKTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGYVETFYPK......
B2BW31_9GAMC/6193-6349                 ..................................s-QLFTEQRSFED.FLPLSVMERDFLNMEAPQFIAKYDCK.GL.GL...E..HVLYGDFSKK..VIGGAHLTIGLARLYIQEKFDVHEISPSsFDVF......KSYFVV..-THAGAMKQVC.TVLDVLLD...DFISILKEIKVSHkgvVSEVLHYIVDYQTVDFMLWMG.DNAINTFYPK......
F2YDB1_SARS/6620-6773                  ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
B1PHI6_9ALPC/6532-6686                 ..................................d-GIFTQGRNVSI.FEPRSEMESDFLNLDMGLFISKYGLE.DY.AF...E..HIVFGDVSKN..TLGGLHLLISQVRLSKMGVLKVEDFVSStDSTL......KSCSVT..YVNDPSSKMVC.TYMDILLD...DFVGILKSLDLSV...VSKVHEVIVDCKVYRWMLWCK.DYKVQTFYPQ......
R1AB_BCHK9/6480-6631                   ..................................d-GYFTQSRTVDD.FQPRTQLEIDFLDLEQSCFLDKYDLH.DL.GL...E..HIVYGQFD-G..TIGGLHLLIGAVRRKRTAHLVMETVLGT.-DTV......TSYAVI..DQPTASSKQVC.SVVDIILD...DFIALIKAQDRSV...VSKVVQCCLDFKVFRFMLWCK.GGKISTFYPQ......
A0A140ESF0_9NIDO/5837-5986             ..................................a-TTCTQGRNVEQ.FIPKTPMERDFLEMSQQSFIQQHQLQ.EL.GV...E..HIIYGDDSSP..VIGGTHTLISLVKNKFE----HQLVNHV.YNPV......QNCVVT..-SPNASSKNVC.TVLDVLLD...DYIDIIRQAHASYt.sKSKVFTVSIDNQQIRFMLWH-.DEQVKTCYP-i.....
D9J202_9ALPC/6215-6369                 ..................................d-GFYSQGRTFDT.FKPRSKMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TLGGMHLLISQVRLSKMGLFSVQEFMTNsDSTL......KSCCVT..YADDPSSKSLC.TYMDILLD...DFVTIVKSLDLSV...VSKVVDVVVDCKVWRWMLWCE.NATIKTFYPQ......
A0A023YA54_MERS/6721-6874              ..................................s-SFYTQGRSNED.FAPMSDMEKDFLSLESDVFIKKYKLE.NY.AF...E..HVVYGDFSHT..TLGGLHLLIGLHKKSVEGHIIMEEMLKG.SATI......HNYFIT..ETNTASFKAVC.SVIDLKLD...DFVEIIKSQDLSV...VSKVVKVPIDLTLVEFMLWCK.DGQVQTFYPR......
A0A125R5A3_9ALPC/6240-6394             ..................................d-SYYTQGRTFET.FKPRSTMEEDFLSMDTTLFIQKYGLE.DY.GF...E..HVVFGDVSKT..TIGGMHLLISQVRLARMGLFSVQEFMNNsDSTL......KSCCIT..YADDPSSKNVC.TYMDILLD...DFVTIVKSLDLNV...VSKVVDVIVDCKAWRWMLWCE.NSQIKTFYPQ......
A3EXE7_BCHK5/6716-6869                 ...................................DTYYTLGRTVSD.FTPVSEMEKDFLALDSDVFIKKYKLE.DY.AF...E..HVVYGDFSRT..TLGGLHLLIGLYKKHQEGHIIMEEMLKE.RVTV......HNYFIT..ESNTASFKAVC.SVIDLKLD...DFVDIIKAMDLSV...VSKVVKIPIDLTMIEFMLWCK.DGQVQTFYPR......
R1AB_CVMA5/6722-6875                   ..................................g-TIFTQSRLLSS.FTPRSEMEKDFMDLDDDVFIAKYSLQ.DY.AF...E..HVVYGSFNQK..IIGGLHLLIGLARRQQKSNLVIQEFVTY.DSSI......HSYFIT..DENSGSSKSVC.TVIDLLLD...DFVDIVKSLNLKC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
A0A088DIE1_9BETC/6793-6946             ..................................n-SYFTQSRVKSS.FEPRTTMERDFLELDMHGFIQRYNLE.KY.AF...E..HIVYGDFSHK..QIGGLHLLIGLIKRCNESTIDIEEFLTM.DSTI......HNYFVT..DQNTGSSKAVC.SVIDLLLD...DFVEIIKSQDLTV...VSKVVKVFIDFRDFDFMLWCK.DGVVQTFYPR......
Q06BE0_9BETC/2188-2341                 ..................................s-TIFTQSRVISS.FTCRTDMEKDFIALDQDLFIQKYGLE.DY.AF...E..HIVYGNFNQK..IIGGLHLLIGLYRRQQTSNLVIQEFVSY.DSSI......HSYFIT..DEKSGGSKSVC.TVIDILLD...DFVALVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.DEKVMTFYPR......
A0A0K1YZY7_SARS/6620-6773              ..................................e-TYFTQSRDLED.FKPRSQMETDFLELVMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYVEISFMLWCK.DGHVETFYPK......
E0ZN59_BCHK9/6455-6606                 ..................................d-GYFTQSRTLND.FQPRTQLEIDFLDLEQSCFLDKYDLH.DL.GL...E..HIAYGQFD-G..TIGGLHLLIGAVRRKRTANLVMETVLGT.-DTV......TAYAVI..DQPTASSKQVC.SVFDMVLD...DFIALIRAQDRSV...VSKVVQCCLDFKMFRFMLWCK.DGKVATFYPQ......
A3EXC0_BCHK4/6672-6825                 ...................................DTFYTCGRTVGD.FTVLTPMEEDFLVLDSDVFIKKYGLE.DY.AF...E..HVVYGDFSHT..TLGGLHLLIGLYKKMREGHILMEEMLKD.RATV......HNYFIT..DSNTASYKAVC.SVIDLRLD...DFVTIIKEMDLDV...VSKVVKVPIDLTMIEFMLWCR.DGKVQTFYPR......
T2B9U0_MERS/6620-6773                  .................................ec--IYTQSRSCSD.FLPLSDMEKDFLSFDSDVFIKKYGLE.NY.AF...E..HVVYGDFSHT..TLGGLHLLIGLYKKQQEGHIIMEEMLKG.SSTI......HNYFIT..ETNTAAFKAVC.SVIDLKLD...DFVMILKSQDLGV...VSKVVKVPIDLTMIEFMLWCK.DGQVQTFYPR......
R1AB_CVM2/6670-6823                    ..................................g-TIFTQSRFLSS.FAPRSEMEKDFMDLDEDVFIAKYSLQ.DY.AF...E..HVVYGSFNQK..IIGGLHLLIGLARRQQKSNLVIQEFVPY.DSSI......HSYFIT..DENSGSSKSVC.TVIDLLLD...DFVDIVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
A0A0Y0BX48_9NIDO/3254-3366             ..................feldircyldakerdfa------------.--------------------------.-L.KN...A..HAFIGDTKGT..TVGGCHHITSRYLPKE---LPKDSVIKV.--GV......SKCGVA..------HKACC.TVTDIYLP...DLE---PYTNPST...ASKVYKVNVDHRPSRLMVWKD.----------atmyf.
A0A089FYB2_9NIDO/3255-3367             ..................feldirgylneeerkfa------------.--------------------------.-L.AH...P..HAFIGDTKGT..TVGGCHHITSKYLPKE---IPAGSVV--.----......-KVGVS..-KTGVAHKSCC.TLTDVYLP...DLQP---YTNPPT...ASRVYKVNVDYRPSRLMVWKD.----------stmyf.
E0XIZ2_9BETC/6611-6764                 ..................................e-TYFTQSRSLDD.FKPRSQMEVDFLQLAMDEFIERYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSLESLLKLEDFIPI.DSTV......KNYFVT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...VSKVVTVTIDYAEISFMLWCK.DGHVETFYPK......
A0A1L3KIY4_9NIDO/7027-7151             .............................ienddh------------.--------------------EQFEGE.GI.FN...A..HIDLGEWSNTsyTIGGNHMFPSAFKDTQ-----YKEVYPNdRLPT......HTFDIV..--KGLGIKALC.SVIDVKTN...DFYALLHTMINEK..tISLKSTIYIDFQPIPIMIWAS.EGTILTAYTQ......
H9BR24_9NIDO/5778-5927                 ..................................v-DYYTQGRTLKD.FVPRTTMEVDFMSLTPQEFVHKYDLH.NL.GI...D..HILYGDVTTR..VIGGCHALISLYYRK----LNVDSVVAH.AQPV......QNAIII..-ASDGKSKEVC.TFVDLTID...DYIDIIKRAHSLYq.tQSKVFYVNIDGHNTRFVIWH-.DDVVRTCYPV......
A0A0K2RW65_9BETC/6663-6816             ..................................s-TIFTQSRVISS.FTCRTDMEKDFIALDQDVFIQKYGLE.DY.AF...E..HIVYGNFNQK..IIGGLHLLIGLYRRQQTSNLVIQEFVSY.DSSI......HSYFIT..DQKSGGSKSVC.TVIDILLD...DFVALVKSLNLNC...VSKVVNVNVDFKDFQFMLWCN.DEKVMTFYPR......
A0A0A7UXR0_9BETC/6684-6837             ..................................g-NLFTQSRQLET.FEPRSEMERDFVQLEDEVFIQKYGLE.DY.AF...E..HIVYGSFNQK..IIGGLHLLIGLYRRQQTSKLEIQEFIEY.DSSI......HSYFIT..DQKSGSSKSVC.TVLDLLLD...DFVALVKSLDLNC...VSKVVNVNVDFKDFQFMLWCN.SDKVMTFYPR......
A0A0B5JQL5_9NIDO/3468-3570             ...........................eravalrh------------.--------------------------.--.--...P..HALIGEDHSK..TLGGCHHITSKYLPEQ---------LPE.TKAV......VRVGVS..-SVGKSAKALC.TVTDVYLP...RLEPF---TQITG...VSKVVPICVDCSTQRLMVWRD.----------atfyfq
R1AB_BC279/6626-6779                   ..................................e-TYFTQSRDLED.FKPRSKMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPT.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
B7SCK8_EAV/2941-3055                   ................rfetnsrafldeaeekfaa------------.--------------------------.--.AH...P..HACLGEINKS..TVGGSHFIFSQYLPP---------LLPAdAVAL......VGAS--..-LAGKAAKAAC.SVVDVYAP...SFEPYLHPETL--...-SRVYKIMIDFKPCRLMVWRN.----------atfyvq
A3EXA2_BCHK4/6662-6815                 ...................................DTFYTCGRTVGD.FTVLTPMEEDFLVLDSDVFIKKYGLE.DY.AF...E..HVVYGDFSHT..TLGGLHLLIGLYKKMREGHILMEEMLKD.RATV......HNYFIT..DSNTASYKAVC.SVIDLRLD...DFVTIIKEMDLDV...VSKVVKVPIDLTMIEFMLWCR.DGKVQTFYPR......
A0A0U1WHG1_9ALPC/6141-6295             ..................................d-GYYTQGRTIST.FLPRSQMEEDFLNMDEGFFISKYGLE.DF.AF...E..HVVYGDVSKT..TLGGLHLLISQVRLGKMGVLNVEDFVSSnDSTL......KSCTVT..YANDPSSKMVC.TYVDLLLD...DFVCLLKSLDLSV...VSKVHEVVLDCKIWRWMLWCK.DNKVQTFYPQ......
Q6UZF5_SARS/6620-6773                  ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
R9QTA1_SARS/2175-2328                  ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DARTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...VSKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
Q9J3E8_9BETC/2279-2432                 ..................................g-TIFTQSRLLSS.FTPRSEMEKDFMDLDDDVFIAKYSLQ.DY.AF...E..HVVYGSFNQK..IIGGLHLLIGLARRQQKSNLVIQEFVTY.DSSI......HSYFIT..DENSGSSKSVC.TVIDLLLD...DFVDIVKSLNLKC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
#=GR Q9J3E8_9BETC/2279-2432      SS    ..................................S--B------GGG.----SHHHHHHHHS-HHHHHHHTT-C.CC.-H...H..HHCC-B-SSS..B-B---BHHHHHHHCTTS-EEEE-SS-S.--SE......EEEEEE..ETTTTEEEEEE.EEE---HH...HHHHHHCC----S...SSEEEEEEETTEEEEEEEETT.EEEE---XXX......
B8Q8U6_SARS/6620-6773                  ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
E0ZN51_BCHK9/6475-6626                 ..................................d-GYFTQSRTLDN.FQPRTQLELDFLDLDESCFLDRYDLH.DL.GL...E..HIAYGQFE-G..TIGGLHLLIGAVRRRRTANLVMETVLGT.-DTV......TSYAVI..DQPTAANKQVC.SVFDMVLD...DFVALIKSQDRTV...VSKVVQCCLDFKMFRFMLWCK.DGKIATFYPQ......
A8JNZ0_9ALPC/6271-6425                 ..................................d-GYYSQGRNAST.FLPRSQMEKDFLELDTGLFISKYGLE.DF.NF...E..HIVYGDVSKT..TLGGLHLLISQVRLARIGVLKVEDFVDSaDDTL......HSCSVT..YANDPSSKSVC.TYMDILLD...DFVVILRNLDLSV...TSKVHDVIVDCKAWRWMLWCK.DSKVATFYPQ......
A0A0U1WHK4_SARS/6620-6773              ..................................e-TYFTQSRDLED.FKPRSQMETDFLELAMDEFIQRYKLE.GY.AF...E..HIVYGDFSHG..QLGGLHLMIGLAKRSQDSPLKLEDFIPM.DSTV......KNYFIT..DAQTGSSKCVC.SVIDLLLD...DFVEIIKSQDLSV...ISKVVKVTIDYAEISFMLWCK.DGHVETFYPK......
R1AB_BCHK4/6662-6815                   ...................................DTFYTCGRTVGD.FTVLTPMEEDFLVLDSDVFIKKYGLE.DY.AF...E..HVVYGDFSHT..TLGGLHLLIGLYKKMREGHILMEEMLKD.RATV......HNYFIT..DSNTASYKAVC.SVIDLRLD...DFVTIIKEMDLDV...VSKVVKVPIDLTMIEFMLWCR.DGKVQTFYPR......
R1AB_CVMJH/6726-6879                   ..................................g-TIFTQSRFLSS.FSPRSEMEKDFMDLDEDVFIAKYSLQ.DY.AF...E..HVVYGSFNQK..IIGGLHLLIGLARRPKKSNLVIQEFVPY.DSSI......HSYFIT..DENSGSSESVC.TVIDLLLD...DFVDIVKSLNLKC...VSKVVNVNVDFKDFQFMLWCN.EEKVMTFYPR......
#=GC SS_cons                           ................HHHHT..S.SSHHHHHHHC-SB-B----STT.----SHHHHHHHHS-HHHHHHHTT-T.TS.CH...H..HHTTCBCSSS..BCBTEEBHHHHHHHHCCS-EEEEESSSSSSESS......EEEEEE..ETTTTEEEEEE.EEB-B-HH...HHHHHHCTSSTSS...SEEEEEEEETTEEEEEEEEEE.TTEEEEEEEXTEEEEE
#=GC seq_cons                          ..................................s.shaTQuRshps.FhPRopMEpDFLphs.s.FIp+YsLE.sa.uF...E..HlVYGDhocs..slGGLHLLIuhh+hpp.u.lhhp-hls..csol......+shhlT...ssssSSKsVC.TllDlLLD...DFVsllKshcLss...VSKVhpVslDh+shcaMLWCc.-scVpTFYPp......
//
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