#=GF ID CoV_NSP2_N
#=GF AC PF19211.3
#=GF DE Coronavirus replicase NSP2, N-terminal
#=GF PI Corona_NS2_N;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE Bateman A
#=GF GA 29.70 29.70;
#=GF TC 52.00 52.00;
#=GF NC 28.30 27.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16227261
#=GF RT The nsp2 replicase proteins of murine hepatitis virus and severe
#=GF RT acute respiratory syndrome coronavirus are dispensable for viral
#=GF RT replication.
#=GF RA Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR;
#=GF RL J Virol. 2005;79:13399-13411.
#=GF DR INTERPRO; IPR043615;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry corresponds to the N-terminal region of coronavirus
#=GF CC non-structural protein 2. NSP2 is encoded by ORF1a/1ab and
#=GF CC proteolytically released from the pp1a/1ab polyprotein. The
#=GF CC function of this protein is uncertain. This region contains
#=GF CC numerous conserved and semi-conserved cysteine residues.
#=GF SQ 82
#=GS A0A0U1UZ20_9ALPC/113-316 AC A0A0U1UZ20.1
#=GS B1PHI7_9ALPC/111-318 AC B1PHI7.1
#=GS R1A_CVPPU/110-310 AC P0C6V2.1
#=GS H9TEW9_9ALPC/110-310 AC H9TEW9.1
#=GS Q6UZF5_SARS/182-423 AC Q6UZF5.1
#=GS U5WI49_SARS/182-423 AC U5WI49.1
#=GS R1A_BCHK5/196-441 AC P0C6T5.1
#=GS R1AB_SARS2/182-423 AC P0DTD1.1
#=GS A0A0U1WJY1_SARS/182-423 AC A0A0U1WJY1.1
#=GS A0A125R5A3_9ALPC/110-310 AC A0A125R5A3.1
#=GS A0A0U1WHF6_9ALPC/111-315 AC A0A0U1WHF6.1
#=GS R1AB_BC279/182-423 AC P0C6V9.1
#=GS I1VWF3_CVH22/112-316 AC I1VWF3.1
#=GS R1AB_FIPV/110-310 AC Q98VG9.2
#=GS A8JNZ0_9ALPC/111-315 AC A8JNZ0.1
#=GS R1A_BC279/182-423 AC P0C6F5.1
#=GS A0A1X9JQL5_9ALPC/114-287 AC A0A1X9JQL5.1
#=GS A3EXI1_BCHK9/191-395 AC A3EXI1.1
#=GS A8JNZ1_9ALPC/111-315 AC A8JNZ1.1
#=GS A0A0U1UZA8_9ALPC/111-318 AC A0A0U1UZA8.1
#=GS S5Z1D1_9ALPC/111-314 AC S5Z1D1.1
#=GS R1A_SARS2/182-423 AC P0DTC1.1
#=GS U5WLB9_SARS/182-423 AC U5WLB9.1
#=GS R1AB_BC512/111-320 AC P0C6W0.1
#=GS I1VWF4_CVH22/112-316 AC I1VWF4.1
#=GS A3EXI9_BCHK9/191-395 AC A3EXI9.1
#=GS R1A_BC512/111-320 AC P0C6F6.1
#=GS B1PHI6_9ALPC/111-318 AC B1PHI6.1
#=GS A0A0K1Z0N1_SARS/182-423 AC A0A0K1Z0N1.1
#=GS B1PHK0_9ALPC/113-316 AC B1PHK0.1
#=GS H9TEX0_9ALPC/110-310 AC H9TEX0.1
#=GS R1A_BC133/196-440 AC P0C6F7.1
#=GS A0A0K1YZY7_SARS/182-423 AC A0A0K1YZY7.1
#=GS D9J203_9ALPC/111-312 AC D9J203.1
#=GS E3W5I8_9ALPC/110-310 AC E3W5I8.1
#=GS C6GHE4_9ALPC/110-310 AC C6GHE4.1
#=GS D9J202_9ALPC/111-312 AC D9J202.1
#=GS Q5DIC6_SARS/182-423 AC Q5DIC6.1
#=GS A0A2H4MZ81_9NIDO/142-352 AC A0A2H4MZ81.1
#=GS R1AB_BCHK5/196-441 AC P0C6W4.1
#=GS A0A096XNJ3_9ALPC/114-290 AC A0A096XNJ3.2
#=GS A0A023YA54_MERS/196-445 AC A0A023YA54.1
#=GS A0A125R5A4_9ALPC/110-310 AC A0A125R5A4.1
#=GS A0A0U1WHD1_9ALPC/112-316 AC A0A0U1WHD1.1
#=GS A0A0U1WHB2_9ALPC/111-318 AC A0A0U1WHB2.1
#=GS R1AB_BCHK9/191-395 AC P0C6W5.1
#=GS R1AB_CVH22/112-316 AC P0C6X1.1
#=GS A0A0U1UZC3_9ALPC/112-317 AC A0A0U1UZC3.1
#=GS B1PHK1_9ALPC/113-316 AC B1PHK1.1
#=GS R1A_SARS/182-423 AC P0C6U8.1
#=GS Q5DIC7_SARS/182-423 AC Q5DIC7.1
#=GS R1AB_BCHK4/196-440 AC P0C6W3.1
#=GS A0A1B3Q5W8_9BETC/191-395 AC A0A1B3Q5W8.1
#=GS R1A_CVH22/112-316 AC P0C6U2.1
#=GS A0A172B201_9ALPC/111-312 AC A0A172B201.1
#=GS E3W5I9_9ALPC/110-310 AC E3W5I9.1
#=GS T2B9U0_MERS/194-443 AC T2B9U0.1
#=GS A0A0U1WHG4_9ALPC/111-315 AC A0A0U1WHG4.1
#=GS R1AB_SARS/182-423 AC P0C6X7.1
#=GS T2B9I2_MERS/194-443 AC T2B9I2.1
#=GS A0A1L2KGB4_9ALPC/111-315 AC A0A1L2KGB4.1
#=GS A0A0U1UZ30_9ALPC/99-303 AC A0A0U1UZ30.1
#=GS U5LR11_9BETC/201-450 AC U5LR11.1
#=GS S5YAF0_9ALPC/111-314 AC S5YAF0.1
#=GS A3EXH3_BCHK9/191-395 AC A3EXH3.1
#=GS A0A088DIE1_9BETC/176-416 AC A0A088DIE1.1
#=GS R9QTH2_SARS/182-423 AC R9QTH2.1
#=GS A0A1L2KGB5_9ALPC/111-315 AC A0A1L2KGB5.1
#=GS U5KNA9_9BETC/201-450 AC U5KNA9.1
#=GS K4K1U5_9ALPC/111-315 AC K4K1U5.1
#=GS A0A059VJE6_9ALPC/111-316 AC A0A059VJE6.1
#=GS R9QTB2_SARS/182-423 AC R9QTB2.1
#=GS R1A_BCHK4/196-440 AC P0C6T4.1
#=GS R1AB_CVPPU/110-310 AC P0C6Y5.1
#=GS A0A240FW17_9ALPC/111-292 AC A0A240FW17.1
#=GS R1AB_BC133/196-440 AC P0C6W1.1
#=GS Q6UZF1_SARS/182-423 AC Q6UZF1.1
#=GS R1A_BCHK9/191-395 AC P0C6T6.1
#=GS A0A2Z4EVM4_9NIDO/188-394 AC A0A2Z4EVM4.1
#=GS A0A0U1WHG1_9ALPC/109-313 AC A0A0U1WHG1.1
#=GS C6GHE5_9ALPC/110-310 AC C6GHE5.1
#=GS A0A172B3C8_9ALPC/111-312 AC A0A172B3C8.1
A0A0U1UZ20_9ALPC/113-316 .gp--VYVDNYMCGANGKPVLPADVWVFQD...YFGDETE..................LIV.NGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL....TDIPHTL..RSGSKLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNgstl......reavPKPVFAHAYVACK-CGRKSWSVGDWS.GYKSTCCGVFG.KPQCV..-VFGEVVPGDV-..........................FITT.SSVGS....GTRY.--YNGLTVKHV......VTVDGLACW
B1PHI7_9ALPC/111-318 ..t-SIPVDNYMCGANGKPVITEDMWYFCD...YFGDDGD.................kITI.NGQEYHKA.......WNVTRS.DVPYQFQNAGTILSIEYV....STEAHVL..PDGAIAKTAKPPKFSKNVVLSEKCKALYDACGSPFVTNgtnv......levvTNPIFAHGFVQCK-CGSKHWTTGDWS.GFKSVCCGTPG.RVLCT..-VFGGVTPGSI-..........................LLTS.TRVDAt.pgATRY.--YHGLTLKHI......CNVDDVACW
R1A_CVPPU/110-310 .ga--IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI..................IEF.EGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdcl......skcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTS.MSAGK....GVKF.--FANCVLQYA......GDVEGVSIW
H9TEW9_9ALPC/110-310 .ga--IYVDQYMCGADGKPVIEG---DFKD...YFGDEDV..................IEF.EGEDYHCA.......WTVVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYRKLYDIFGSPFMGNgdcl......skcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDVKPGDA-..........................VVTS.MSAGK....GVKF.--FANCVLQHA......GDVENVSIW
Q6UZF5_SARS/182-423 ..v-TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
U5WI49_SARS/182-423 .ft--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEVA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLDSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.SVTEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
R1A_BCHK5/196-441 ..d-FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAevksr.......tdsdryIVF.KNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLdtmeDVPRHSF.tIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE..............PNYIYHSAYVDCTSCGKGSWLTGNAVqGFACDCGAHYCaNDVDL..QSSGLVRKNAVLlttcpcnkdge....ckhtlpqlvsmMTDK.CDVEV...vGKTFiLTYGGVIYAYM......GCSGGTMHF
R1AB_SARS2/182-423 ..y-TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKasctlseqldfidtkrgvYCC.REHEHEIA.......WYTERS.EKSYELQTPFEIKLAKKFdtfnGECPNFVfpLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNEC--..............-NQMCLSTLMKCDHCGETSWQTGDFV.KATCEFCGTENlTKEGA..TTCGYLPQNAVVkiycpachnsev..gpehslaeyhneSGLK.TILRK....GGRT.IAFGGCVFSYV......GCHNKCAYW
A0A0U1WJY1_SARS/182-423 .ft--RYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldyieskrgvYCC.REHEHEIV.......WFTERS.EKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTESFMGRIRSVYPVATPQE---..............CNDMHLSTLMKCNHCDEVSWQTCDFL.KATCEQCGTEN.LVCEG.pTTCGYLPTNAVVkmpcpacqdpevgpehsvadyhnhsnIETR.LRKGG....RTKC.--FGGCVFAYV......GCYNKRAYW
A0A125R5A3_9ALPC/110-310 .ga--IYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLCQQNLLTIKEIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEDYRKLYDIFGSPFMGNgdsl......nkcfANLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................VITS.MSAGK....GVKF.--FANSVLQYA......GDVENVSVW
A0A0U1WHF6_9ALPC/111-315 ...NVVFVDNYMCGADGKPAVPREQWSFEE...HFDDDTE.................dIII.NGVTYRHA.......WNTIRA.DDPYEKQGLLSIKSIEYV....STIPHKL..PNGSVLSVAGPPKKRKAVVLDEKYNKIYNACGVPFVTNgksi......sevvTKPLFLHALVKCK-CGNESWTVGDWT.GFKTTCCGATG.KVTTF..-AVGDVTPGDI-..........................VFTT.TGAGT....GTKF.--FCGLVLTHV......DTLEGVSAW
R1AB_BC279/182-423 .ft--RYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldyieskrgvYCC.REHEHEIV.......WFTERS.EKSYERQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQE---..............CNDMHLSTLMKCNHCDEVSWQTCDFL.KATCEQCGTEN.LVCEG.pTTCGYLPANAVVkmpcpacqdpevgpehsvadyhnhsnIETR.LRKGG....RTKC.--FGGCVFAYV......GCYNKRAYW
I1VWF3_CVH22/112-316 ...NVTYTDQYLCGADGKPVISDDLWQFVD...HFGENEE..................III.NGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYV...rGDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNgsni......leafIKPVFISAFVQCT-CGNKSWSVGDWT.GFKSTCCNVLS.KKLCV..-VPGNVKPGDA-..........................VVTT.QQAGV....GVKY.--FCGMTLKFV......ANIEGVSVW
R1AB_FIPV/110-310 .ga--IYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLWQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNgdsl......ntcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................IVTS.MSAGK....GVKF.--FANSVLQYA......GDVENVSVW
A8JNZ0_9ALPC/111-315 ...DVVPVDNYMCGADGKPAVPSEQWSFVE...HFDDDTD.................eITV.NGVTFRHA.......WNTVRA.DDPYEKQGLLSIKFIEYI....SNVPHKL..PNGSVLGVAGTPKKRKAVVLDEKYSKLYDACGVPFVTNgksi......sevvTKPLFLHALVECK-CGNESWTVGDWT.GFKTTCCGVTG.KVITL..-AVGDVTPGDI-..........................VFTT.PGAGK....GTKF.--FCGLVLTFV......DTLEGVSAW
R1A_BC279/182-423 .ft--RYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldyieskrgvYCC.REHEHEIV.......WFTERS.EKSYERQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQE---..............CNDMHLSTLMKCNHCDEVSWQTCDFL.KATCEQCGTEN.LVCEG.pTTCGYLPANAVVkmpcpacqdpevgpehsvadyhnhsnIETR.LRKGG....RTKC.--FGGCVFAYV......GCYNKRAYW
A0A1X9JQL5_9ALPC/114-287 ..n-PIFVDQYLCGADGTPVK--RDVEFKN...YFTDGDT..................YVE.PGKTYKLV.......WNVERK.PGDL---TLSGILSIKYL....SDKPHKL..RDGVVQEVADAVS-----ELNDT-KQL-----------..............--VRFIHGFVSCP-CGKSAFTVGGWN.GFATVCCGVTVkSPICV..KFSGK--AGSIF..........................ALPLgSRVFG....TKRI.--YAGAEFQYC......CDLSGVEIW
A3EXI1_BCHK9/191-395 ..l-VKPVLELLGGIKPDLTLEKLTLALSE...YRNSDG-..................YDL.PGGFVRVA.......VSVIRK.PVPVVKQTIFTVQGVVEQhvegFYYPYS-..TMSVVKHTKPRSDKPLGKTVESIMLSLYGTSG------..............YSPATPVVRLRCSYCDFYGWVPPRDMgTVVCSCGAEFQlTSACVdaESAGAIKPGCVM..........................LLDR.SPGMRl.ipGNRIyVAFGGAIWSPI......GTVNGVSVW
A8JNZ1_9ALPC/111-315 ...DVVPVDNYMCGADGKPAVPSEQWSFVE...HFDDDTD.................eITV.NGVTFRHA.......WNTVRA.DDPYEKQGLLSIKFIEYI....SNVPHKL..PNGSVLGVAGTPKKRKAVVLDEKYSKLYDACGVPFVTNgksi......sevvTKPLFLHALVECK-CGNESWTVGDWT.GFKTTCCGVTG.KVITL..-AVGDVTPGDI-..........................VFTT.PGAGK....GTKF.--FCGLVLTFV......DTLEGVSAW
A0A0U1UZA8_9ALPC/111-318 ..t-SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDDGD.................nITV.NGQAYHKA.......WNVTRS.DVPYQFQNASTILSIEYL....ADEKHVL..PDGAVAKTAKPPKFSKNIVLSEKYKALYDACGSPFVTNgtnv......levvTNPIFAHGFVQCK-CGSKHWTTGDWA.GFKSVCCGIPG.RVLCT..-VFGGVAPGSV-..........................LLTS.TRVDAs.pgAARY.--YHGLTLKHI......CNVDGVACW
S5Z1D1_9ALPC/111-314 ...NTIYVDQYLCGADGKPVVPEEFWDFKD...YFVDDDQ..................VVV.NGTTYIKA.......WVVERA.NVAYEAQNVTAINGITYC....AKIPHTL..PDGSVVRVARKPKIKKSIVLSDVYKPLLEGLGAPFVKNgdtl......asilTEPVFLHALVKCT-CGKTMWTVGDWS.CYKSLCCGVVC.KPLCN..-VAGIVNPGSA-..........................VVTR.TGLGS....GIKY.--YCGMFLRHI......LDVDGVSVW
R1A_SARS2/182-423 ..y-TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKasctlseqldfidtkrgvYCC.REHEHEIA.......WYTERS.EKSYELQTPFEIKLAKKFdtfnGECPNFVfpLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNEC--..............-NQMCLSTLMKCDHCGETSWQTGDFV.KATCEFCGTENlTKEGA..TTCGYLPQNAVVkiycpachnsev..gpehslaeyhneSGLK.TILRK....GGRT.IAFGGCVFSYV......GCHNKCAYW
U5WLB9_SARS/182-423 .ft--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEVA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLDSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.SVTEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
R1AB_BC512/111-320 ..t-TIPVDQFMCGADGAPVIQEGDWTFMD...YFQDSNQ..................FTL.NGITYVKA.......WDVDRK.PNDYAKQNVTCIRRITYI....TDHRHVL..ADGTTMKTARHPKVNKSVVLDSPFDQIYKEVGSPFMGNgstf......vemlKDPAFFHALITCE-CGRSEWTVGDWK.GYNSLCCNIKC.KPITI..-VTPKAVPGAV-..........................VITK.AGIGA....GLKC.--YNNVFLKHIidlvvpGTNLGWGVW
I1VWF4_CVH22/112-316 ...NVTYTDQYLCGADGKPVISDDLWQFVD...HFGENEE..................III.NGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYV...rGDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNgsni......leafIKPVFISAFVQCT-CGNKSWSVGDWT.GFKSTCCNVLS.KKLCV..-VPGNVKPGDA-..........................VVTT.QQAGV....GVKY.--FCGMTLKFV......ANIEGVSVW
A3EXI9_BCHK9/191-395 ..l-VKPVQDLLGDIRPDFTLEELTLCLSD...YRTDDG-..................YDL.LGGYVKVA.......VKVVRK.PVPVVKQTIFTVQGVIEQcvegYYYPFP-..PMSAVKHTKPRSDKPLGKTVDSIMLSLYGTSG------..............YNPATPVVRLRCSHCDFYGWVPLKDMgTVSCSCSAVHQlTSSCIdaESAGAIKPGCVM..........................LLDK.SPGMRv.ipGNRTyVAFGGAIWSPI......GKVGDVTVW
R1A_BC512/111-320 ..t-TIPVDQFMCGADGAPVIQEGDWTFMD...YFQDSNQ..................FTL.NGITYVKA.......WDVDRK.PNDYAKQNVTCIRRITYI....TDHRHVL..ADGTTMKTARHPKVNKSVVLDSPFDQIYKEVGSPFMGNgstf......vemlKDPAFFHALITCE-CGRSEWTVGDWK.GYNSLCCNIKC.KPITI..-VTPKAVPGAV-..........................VITK.AGIGA....GLKC.--YNNVFLKHIidlvvpGTNLGWGVW
B1PHI6_9ALPC/111-318 ..t-SIPVDNYMCGANGKPVITEDMWYFCD...YFGDDGD.................kITI.NGQEYHKA.......WNVTRS.DVPYQFQNAGTILSIEYV....STEAHVL..PDGAIAKTAKPPKFSKNVVLSEKCKALYDACGSPFVTNgtnv......levvTNPIFAHGFVQCK-CGSKHWTTGDWS.GFKSVCCGTPG.RVLCT..-VFGGVTPGSI-..........................LLTS.TRVDAt.pgATRY.--YHGLTLKHI......CNVDDVACW
A0A0K1Z0N1_SARS/182-423 .vt--RYVDNNFCGPDGYPLE-----CIKG...LLARAGKsmctlseqldfieskrgvYCC.REHEHEIA.......WYTERS.DKSYEHQTPFDIKSAKKFdtfkEECPKFVfpLNSTVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCSHCDEVSWQTCDFL.KATCEHCGTEN.LVVEG.pTTCGYLPINAVVkmpcpacqnkevgpehsvadyhnysnIETR.LRKGG....RTKC.--FGGCVFSYV......GCYNKRAYW
B1PHK0_9ALPC/113-316 .sp--VYVDNYMCGANGKPVLPADVWVYQD...YFGEETE..................LIV.NGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL....TDIPHTL..RNGSRLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNgstl......reavPKPVFAHAYVACK-CGRKAWSVGDWS.GYKSTCCGVFG.KPQCV..-VFGEVVPGDV-..........................FITT.SSVGS....GTRY.--YNGLTVKHV......VTVDGLACW
H9TEX0_9ALPC/110-310 .ga--IYVDQYMCGADGKPVIEG---DFKD...YFGDEDV..................IEF.EGEDYHCA.......WTVVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYRKLYDIFGSPFMGNgdcl......skcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDVKPGDA-..........................VVTS.MSAGK....GVKF.--FANCVLQHA......GDVENVSIW
R1A_BC133/196-440 ...DCIPVDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYSKQTAFTVVSVIQCddkeSVPEHTF.tIGSQILMVSP-LKATNNKNFNLKQRLLHTFYGKEAVQQ..............PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPKNALFlancpcannga....cshnaaqvysiLDGK.ACVEV...gGKSFtLTFGGVVYAYM......GCCDGTMYF
A0A0K1YZY7_SARS/182-423 .vt--RYVDNNFCGPDGYPLE-----CIKG...LLARAGKsmctlseqldfieskrgvYCC.REHEHEIA.......WYTERS.DKSYEHQTPFDIKSAKKFdtfkEECPKFVfpLNSTVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCSHCDEVSWQTCDFL.KATCEHCGTEN.LVVEG.pTTCGYLPINAVVkmpcpacqnkevgpehsvadyhnysnIETR.LRKGG....RTKC.--FGGCVFSYV......GCYNKRAYW
D9J203_9ALPC/111-312 ..t-VVHVDQFLCGADGKPVRQG---DMKD...YFGDLEE..................IVI.DGITYQHA.......WDVVRDvEVPHAKQTALNVQSIMYL....MDVDHKL..VNGATRQRAAPVKISSKVCLTEPYNSLYKHFGSPYMQNggnl......necfAKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGTPG.KVIGV..-SIGDASVGEA-..........................VITS.KGCGT....GTKF.--YAGAVLKYV......GDAEGVSVW
E3W5I8_9ALPC/110-310 .ga--VYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....RDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRRLYDIFGSPFMRNgdsl......nkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGSVKPGDA-..........................VVTS.MSAGK....GVKF.--FANSVLQYA......GDVENVSVW
C6GHE4_9ALPC/110-310 .ga--IYVDQYMCGADGKPVVEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDVPHKL..PNCAIRKVAPPVKKXSKIFLSEEYRKLYDIFGSPFMGNgdsl......nkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLPG.KVKGI..-TLGAVKPGDA-..........................VITS.MXAGK....GVKF.--FANSVLQYA......GDVENVSVW
D9J202_9ALPC/111-312 ..t-VVHVDQFLCGADGKPVRQG---DMKD...YFGDLEE..................IVI.DGITYQHA.......WDVVRDvEVPHAKQTALNVQSIMYL....MDVDHKL..VNGATRQRAAPVKISSKVCLTEPYNSLYKHFGSPYMQNggnl......necfAKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGTPG.KVIGV..-SIGDASVGEA-..........................VITS.KGCGT....GTKF.--YAGAVLKYV......GDAEGVSVW
Q5DIC6_SARS/182-423 ..v-TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHGIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
A0A2H4MZ81_9NIDO/142-352 .nk--YYVDQYLCDYKGNPVKTVSNFPFKD...HFQGQKE..................VVI.DGNTYCLA.......WEVERV.KSPLATQTATKLRSVTPT....GYFDEA-..PNHIFTGLVTIAKVPKG-DLRTTID--YEVFGLGFVANnfetrflaancqlnGSFTAIDLFTTCGFVKKYHPCCDKWSaGVYKPCFCDKP.NMLGF..YDTDIVSPGTPI..........................LSEC.TDRKV....GSVA.-TLFGKLIKKV......GVVAKVDVW
R1AB_BCHK5/196-441 ..d-FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAevksr.......tdsdryIVF.KNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLdtmeDVPRHSF.tIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE..............PNYIYHSAYVDCTSCGKGSWLTGNAVqGFACDCGAHYCaNDVDL..QSSGLVRKNAVLlttcpcnkdge....ckhtlpqlvsmMTDK.CDVEV...vGKTFiLTYGGVIYAYM......GCSGGTMHF
A0A096XNJ3_9ALPC/114-290 ..n-PIYVDQYLCGPDGTPVKKG--LEFKD...YFMNGGD..................IYVePGKTYVRV.......WDVERK.QDDL---TLDGILSIKYL....SDKPHKL..RDGAIQGVADAVS------------ELNDTNQ------..............-MVRFIHAFVSCP-CGKSAFTVGSWM.GFATVCCGKIVkTPMCV..KFSGEAGSIFAL..........................PVGS.RGFSA...nGKRS.--YAGAEFQFC......CELSGVEIW
A0A023YA54_MERS/196-445 ..d-FIPIDQFMCGKDGAPVPDYATLAASEnliSLADVATdvsar.......adsdgyIDF.KSKLYRIV.......WHVERK.NVPYAKQTIFTINSVVQCdgiqDVPPHTF.tLGGKVDLIVPRNKWTGKTALNLKQKILYTFYGKDALDN..............HSYIYHSAYADCTSCGKGSWLTGNAVqGFACDCGAQYSaNDVEL..QSSGVVNPNAIFcatcpfakgdscsssckhtlaqmvsqLSEK.CDVAP...dGKSFtLAFGGVVYAYL......GCLEGTMYF
A0A125R5A4_9ALPC/110-310 .ga--IYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLCQQNLLTIKEIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEDYRKLYDIFGSPFMGNgdsl......nkcfANLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................VITS.MSAGK....GVKF.--FANSVLQYA......GDVENVSVW
A0A0U1WHD1_9ALPC/112-316 vep--VYVDNYMCGANGKPVLPADVWCFQD...YFGDETE..................LVV.NGVRHVKA.......WDVVRT.NLPYQFQSTGAIESIIWL....SDVPHVL..RNGSKLSVCKAPKFSKNVKLSEPLNTLYQACGSPFVSNgtdl......agavGKPVFAHSYVACK-CGSKCWSVGDWS.GYKSTCCGTFG.KVLCT..-VFGDVVPGDV-..........................LMTS.AAVGS....GTRY.--YNGLTIKHV......VTVQNIACW
A0A0U1WHB2_9ALPC/111-318 ..t-SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDEGD.................nITV.NGQAYHKA.......WNVTRS.DVPYQFQNASTILSIEYL....ADEKHVL..PDGAVAKTAKPPKFSKNIVLSEKYKALYDACGSPFVTNgtnv......levvTNPIFAHGFVQCK-CGSKHWTTGDWA.GFKSVCCGIPG.RVLCT..-VFGGVAPGSV-..........................LLTS.TRVDAs.pgAARY.--YHGLTLKHI......CNVDGVACW
R1AB_BCHK9/191-395 ..l-VEPVMKLLGVIKSDFTLEQLLAALGK...YRTEDG-..................YDL.PDGYVKVA.......IKVGRK.AVPVLKQSIFTVVGVTEQlvpgYYYPFS-..TSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN------..............YNPATPVARLKCSYCDYYGWTPLKDIgTVNCLCGAEFQlTSSCVdaESAGVIKPGCVM..........................LLDK.SPGMRl.ipGNRTyVSFGGAIWSPI......GKVNGVTVW
R1AB_CVH22/112-316 ...NVTYTDQYLCGADGKPVMSEDLWQFVD...HFGENEE..................III.NGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYV...hGDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNgsni......leafTKPVFISALVQCT-CGTKSWSVGDWT.GFKSSCCNVIS.NKLCV..-VPGNVKPGDA-..........................VITT.QQAGA....GIKY.--FCGMTLKFV......ANIEGVSVW
A0A0U1UZC3_9ALPC/112-317 .pp--IYVDNYLCGADGTPVVQESMWSYTD...HFGEDCD.................eITL.CGITYVHA.......WNVQRA.DVPYEQQNVTSIFSIEYL....LDVDHAL..QNGAVLNVASGVKYKKSVVLSEGFKKLYDACGVPAVQNgntl......vdilTKPAFFHAIVSCS-CGLSSYTVGDWKiGFRSLCCGKRL.EPITV..-VVGDVKPGDI-..........................VVTS.ANAGD....GVRY.--FNGLTLQYV......GDWEGVSCW
B1PHK1_9ALPC/113-316 .sp--VYVDNYMCGANGKPVLPADVWVYQD...YFGEETE..................LIV.NGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL....TDIPHTL..RNGSRLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNgstl......reavPKPVFAHAYVACK-CGRKAWSVGDWS.GYKSTCCGVFG.KPQCV..-VFGEVVPGDV-..........................FITT.SSVGS....GTRY.--YNGLTVKHV......VTVDGLACW
R1A_SARS/182-423 ..v-TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
Q5DIC7_SARS/182-423 ..v-TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHGIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
R1AB_BCHK4/196-440 ...DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCddkdSVPEHTF.tIGSQILMVSP-LKATNNKNFNLKQRLLYTFYGKDAVQQ..............PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPRNALFlancpcannga....cshsaaqvyniLDGK.ACVEV...gGKSFtLTFGGVVYAYM......GCCDGTMYF
A0A1B3Q5W8_9BETC/191-395 .la--APIKEVLGGKGAGMSLVELTKFLGK...YRTADG-..................YEL.PSGIVKVA.......VKVVRK.NLPVSKQSIFTVLGVTERvvdgFYYPYS-..TNSVVSYTKPRAGATVGNTVQSVMLSMYGTEA------..............YNPVTPVVRLRCSSCDFYGWVPVKDLgCVTCSCAAVHQiTSSCIdaESAGLIKQGAVM..........................LVDR.SPSMRv.vpGNRLyVAFGGAIWSPI......GKVNGVQVW
R1A_CVH22/112-316 ...NVTYTDQYLCGADGKPVMSEDLWQFVD...HFGENEE..................III.NGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYV...hGDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNgsni......leafTKPVFISALVQCT-CGTKSWSVGDWT.GFKSSCCNVIS.NKLCV..-VPGNVKPGDA-..........................VITT.QQAGA....GIKY.--FCGMTLKFV......ANIEGVSVW
A0A172B201_9ALPC/111-312 ..m-TVYVDQYMCGADGRPVISG---EMRD...YFGDLDD..................IVI.DGIIYSHA.......WDVERDlDVTHDKQTFLNIKSIMYL....QDKDHKL..PNGAIRVRAAPVKLSSKVVLSQPFADMYKHFGSPYMQNgdnl......hgcfTKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGLPG.KVIGV..-SLGNAAVGEA-..........................VVTS.KGCGN....GTKF.--YANAVLKHV......GDADDVSIW
E3W5I9_9ALPC/110-310 .ga--VYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....RDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRRLYDIFGSPFMRNgdsl......nkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGSVKPGDA-..........................VVTS.MSAGK....GVKF.--FANSVLQYA......GDVENVSVW
T2B9U0_MERS/194-443 ...DVTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEAdvaar.......addegfITL.KNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKdgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN..............PTYIYHSAFIECGSCGNDSWLTGNAIqGFACGCGASYTaNDVEV..QSSGMIKPNALLcatcpfakgdscssnckhsvaqlvsyLSER.CNVIA...dSKSFtLIFGGVAYAYF......GCEEGTMYF
A0A0U1WHG4_9ALPC/111-315 ...NTVYVDNYMCGSNGVPVLPEDQWEFVD...YFGELTE..................VSI.GDTTYIKA.......WNVDRV.EGPYKSQTLLSINAISYC....GEVIHAL..ADGSTMSYATAVKKNSKTVVNKTYQKLYDNIGVPFVTNgkvl......teiiPKPVFNHGLVKCH-CGKVSWTVGDWS.CYKSTCCGTVC.KPIAI..-VNGDVNPGDV-..........................VITS.KQVAT...nGVKY.--YNGMVLKYV......DTIEDVHLW
R1AB_SARS/182-423 ..v-TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
T2B9I2_MERS/194-443 ...DVTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEAdvaar.......addegfITL.KNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKdgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN..............PTYIYHSAFIECGSCGNDSWLTGNAIqGFACGCGASYTaNDVEV..QSSGMIKPNALLcatcpfakgdscssnckhsvaqlvsyLSER.CNVIA...dSKSFtLIFGGVAYAYF......GCEEGTMYF
A0A1L2KGB4_9ALPC/111-315 ...DVVFVDNYMCGFDGKPVLPETIWEFKD...YFGDDVD.................nITI.NGVSYQLA.......WDVTRK.PLSYKQQNVLAIESIRYL....GSKEHTL..RAGCKLFNAKQPKYSAKVVLSDEWIEVYKAFGSPFVTNgssl......leilTKPVFFNAFVECN-CGNKGWSVGAWD.GYLSPCCGTPA.KKICV..-VPGNVVPGDV-..........................LVTS.TNAGT....GTKY.--YAGLVVKHV......VNVSGVSLW
A0A0U1UZ30_9ALPC/99-303 ...NTVYVDNYMCGSNGVPVLPEDQWEFVD...YFGELTE..................VSI.GDTTYIKA.......WNVDRV.EGPYKSQTLLSINAISYC....GEVIHAL..ADGSTMSYATAVKKNSKTVVNKTFQKLYDNIGVPFVTNgkvl......teiiPKPVFNHGLVKCH-CGKVSWTVGDWS.CYKSTCCGIVC.KPIAI..-VNGDVNPGDV-..........................VITS.KQVAT...nGVKY.--YNGMVLKYV......DTIEDVHLW
U5LR11_9BETC/201-450 ...DVIPVDQYMCGFDGSPIKPYLDLANKEgltKLADVEAdvcsr.......vdkqgfLIF.KGTTYRVV.......WFTERK.DVDYSKQTLFTVICVMQRn.gvHDIPAHPftLGSKVEQLKPHVAKGNLVGLTLKAKILYTMYGEDAVEE..............PSYIYHSAFVDCVKCNEGKWCTGNAVaGFACECGAAYTaKQVLL..QSSGLVKSNALFcatcpfaqgdrcsldckhtvpqvvsyLSEK.CVVFP...sGKSFvLAFGGALYTYM......GCAEGTMYF
S5YAF0_9ALPC/111-314 ...NTIYVDQYLCGADGKPVVPEEFWDFKD...YFVDDDQ..................VVV.NGTTYIKA.......WVVERA.NVAYEAQNVTAINGITYC....AKIPHTL..PDGSVVRVARKPKIKKSIVLSDVYKPLLEGLGAPFVKNgdtl......asilTEPVFLHALVKCT-CGKTMWTVGDWS.CYKSLCCGVVC.KPLCN..-VAGIVNPGSA-..........................VVTR.TGLGS....GIKY.--YCGMFLRHI......LDVDGVSVW
A3EXH3_BCHK9/191-395 ..l-VKPVRDLLGDIKPDLTLEKLTLALSD...YRKDDG-..................YDL.PGGFVKIA.......VTVIRK.PVAVVKQTIFTVQGVVEQhvegYYYPYA-..PLGVVKQTKPAAGGPIGKTVEAIMLSLYGTSG------..............YKPATPVARLKCSYCDHFGWTPLKDMgTVVCLCGAEYQlTSSCVdaESAGLIKPGCVM..........................LLDK.SPGMRv.ipGNRTyVAFGGAIWSPI......GKVNDVTVW
A0A088DIE1_9BETC/176-416 dfh--RYVDNYYCTGDGKPLP-----CIVT...LLEKAGHankpld......damdylRGL.NRMGQPCRdhdhervWEVERD.NAPYPEQSLFSISAIKTL....GEIPHCVfaPDCAVKVMKPRKVKRGADGFMTKLRRVYNINGFDEV--..............-KPMALCALHYCEDCGMEMWCHSNFE.EAYCPCGKIYT.NTPCT.lTSAGYVVEGSVVampcdacksdsd.hsngtfydsckylAEDK.AEPGN....RENF.VYFGGCCFAYV......GCRNGNAIW
R9QTH2_SARS/182-423 ..v-TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldfieskrgvYCC.REHEHEIA.......WFTERS.EKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSRVKVIQPRVEKKKTEGFMGRIRSVYPVASP---GD..............CNDMHLSTLMKCNHCDEVSWQTCDFL.KATCEQCGTEN.SVREG.pTTCGYLPTNAVLkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RIKC.--FGGCVFAYV......GCYNKRAYW
A0A1L2KGB5_9ALPC/111-315 ...DVVFVDNYMCGFDGKPVLPETIWEFKD...YFGDDVD.................nITI.NGVSYQLA.......WDVTRK.PLSYKQQNVLAIESIRYL....GSKEHTL..RAGCKLFNAKQPKYSAKVVLSDEWIEVYKAFGSPFVTNgssl......leilTKPVFFNAFVECN-CGNKGWSVGAWD.GYLSPCCGTPA.KKICV..-VPGNVVPGDV-..........................LVTS.TNAGT....GTKY.--YAGLVVKHV......VNVSGVSLW
U5KNA9_9BETC/201-450 ...DVIPVDQYMCGFDGSPIKPYLDLANKEgltKLADVEAdvcsr.......vdkqgfLIF.KGTTYRVV.......WFTERK.DVDYSKQTLFTVICVMQRn.gvHDIPAHPftLGSKVEQLKPHVAKGNLVGLTLKAKILYTMYGEDAVEE..............PSYIYHSAFVDCVKCNEGKWCTGNAVaGFACECGAAYTaKQVLL..QSSGLVKSNALFcatcpfaqgdrcsldckhtvpqvvsyLSEK.CVVFP...sGKSFvLAFGGALYTYM......GCAEGTMYF
K4K1U5_9ALPC/111-315 ..t-TVFVDNFLCGANGLPACSEQEWEFKD...HFGELDE..................VTI.NGTTFVKA.......WNVDRT.PGPYSTQNLLSINSISWC....GEIPHSL..ADGSIRRVAKVVKKSKSVLLGKQFQQLYDSVGSPFVTNgknl......sdvlVKPIYCHALVKCQ-CGKTSWTVGDWS.CYKSMCCGFNC.KPLAI..-VNGEVVPGDV-..........................LVTS.DKVSA...sGTKY.--YNGMVLKFV......DKIDNACLW
A0A059VJE6_9ALPC/111-316 ..n-IVPVDQYMCGADGKPVLQESEWEYTD...FFADSEDg................qLNI.AGITYVKA.......WIVERS.DVSYASQNLTSIKSITYC....STYEHTF..PDGTAMKVARTPKIKKTVVLSEPLATIYREIGSPFVDNgsda......rsiiKRPVFLHAFVKCK-CGSYHWTVGDWT.SYVSTCCGFKC.KPVLV..-ASCSATPGSV-..........................VVTR.AGAGT....GVKY.--YNNMFLRHV......ADIDGLAFW
R9QTB2_SARS/182-423 ..v-TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldyieskrgvYCC.REHEHEIV.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQE---..............CNDMHLSTLMKCNHCDEVSWQTCDFI.KATCEQCGTE-.NPVCEgpTTCGYLPTNAVVkmpcpacqdpevgpehsvadyhnhsnIETR.LRKGG....RTKC.--FGGCVFSYV......GCYNKRAYW
R1A_BCHK4/196-440 ...DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCddkdSVPEHTF.tIGSQILMVSP-LKATNNKNFNLKQRLLYTFYGKDAVQQ..............PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPRNALFlancpcannga....cshsaaqvyniLDGK.ACVEV...gGKSFtLTFGGVVYAYM......GCCDGTMYF
R1AB_CVPPU/110-310 .ga--IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI..................IEF.EGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdcl......skcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTS.MSAGK....GVKF.--FANCVLQYA......GDVEGVSIW
A0A240FW17_9ALPC/111-292 ..k-VVYVDNYLCGNNGKPVVPKDKWKILS...KG-QQG-..................LLA.DNVYYKVV.......WDVKRD.DVPYEKQNMSSIVSIRYL....IDIPHFL..ADGAVREKKRPPQDYTTML----------VKGFPFLMA..............YDWKFVNHAVKCGKCDNHVVEAGAFE.SVITSCCRDEI.VHQGV..---VTAKAGEL-..........................VLTP.---LS....NKKL.ILVGSTVLRNI......GTAHNLSIW
R1AB_BC133/196-440 ...DCIPVDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYSKQTAFTVVSVIQCddkeSVPEHTF.tIGSQILMVSP-LKATNNKNFNLKQRLLHTFYGKEAVQQ..............PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPKNALFlancpcannga....cshnaaqvysiLDGK.ACVEV...gGKSFtLTFGGVVYAYM......GCCDGTMYF
Q6UZF1_SARS/182-423 ..v-TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE---..............CNNMHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETR.LRKGG....RTRC.--FGGCVFAYV......GCYNKRAYW
R1A_BCHK9/191-395 ..l-VEPVMKLLGVIKSDFTLEQLLAALGK...YRTEDG-..................YDL.PDGYVKVA.......IKVGRK.AVPVLKQSIFTVVGVTEQlvpgYYYPFS-..TSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN------..............YNPATPVARLKCSYCDYYGWTPLKDIgTVNCLCGAEFQlTSSCVdaESAGVIKPGCVM..........................LLDK.SPGMRl.ipGNRTyVSFGGAIWSPI......GKVNGVTVW
A0A2Z4EVM4_9NIDO/188-394 gvl-VKPIMDLLGPLKSGYTLANLLDDLAP...YKCDDG-..................YEL.PTGTVCVA.......FEVVRK.NVPAAKQNIFTVQGVLNQlvpgIYYPYS-..SGSKVVTTKPARDSPAAKTVSSIMLSLYGTAQ------..............YAPVTPVARIACPTCGFLGWLPLKDAgTVVCGCNATYNmTSTAVqaESSGFIRQGAVL..........................CLEK.GEAMRlipgGRTY.LAFGGAIWSPI......GKDKDVTVW
A0A0U1WHG1_9ALPC/109-313 .ae--VYVDNYMCDQTGKPVLAADVWTFKD...YFGESDT..................IVI.DGVVYRKA.......WEVVRL.DVPYKAQSVSAISSIEWL....CGVQHVL..PSGTVLDVAKSVSKSKVVLLSDPYADIYDQVGSPFMTNgknl......leivVKPCFLHGYVKCN-CGNTHWAVGDWRaGYKSVCCGLNC.NPICV..-AAGYVEPGDV-..........................LFTS.KGAGT....GLKY.--YKGLTLKFV......GEVENVAVW
C6GHE5_9ALPC/110-310 .ga--IYVDQYMCGADGKPVVEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDVPHKL..PNCAIRKVAPPVKKXSKIFLSEEYRKLYDIFGSPFMGNgdsl......nkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLPG.KVKGI..-TLGAVKPGDA-..........................VITS.MXAGK....GVKF.--FANSVLQYA......GDVENVSVW
A0A172B3C8_9ALPC/111-312 ..m-TVYVDQYMCGADGRPVISG---EMRD...YFGDLDD..................IVI.DGIIYSHA.......WDVERDlDVTHDKQTFLNIKSIMYL....QDKDHKL..PNGAIRVRAAPVKLSSKVVLSQPFADMYKHFGSPYMQNgdnl......hgcfTKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGLPG.KVIGV..-SLGNAAVGEA-..........................VVTS.KGCGN....GTKF.--YANAVLKHV......GDADDVSIW
#=GC seq_cons ....shaVDpYhCGsDGcPlh.t...shcD...ahu-ssp..................lsh.puppYchA.......W.spRs.-hsYppQohhsIpulphh....s-hPHtl..hsusltplsstlctspshslstph+pLYsshGsshhtp..............ssshahsAhlcCs.CGptoWssGDah.GapssCCGs.s.pshsl...osGhlssGsl...........................lhTp.tpsGs....Gs+a...FuGslhpal......GshpsluhW
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