GenomeNet

Database: Pfam
Entry: CoV_NSP4_C
LinkDB: CoV_NSP4_C
Original site: CoV_NSP4_C 
#=GF ID   CoV_NSP4_C
#=GF AC   PF16348.7
#=GF DE   Coronavirus replicase NSP4, C-terminal
#=GF PI   Corona_NSP4_C;
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   PDB:3gzf
#=GF GA   27.00 27.00;
#=GF TC   74.40 74.40;
#=GF NC   23.50 18.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19622868
#=GF RT   Structure of the C-terminal domain of nsp4 from feline
#=GF RT   coronavirus.
#=GF RA   Manolaridis I, Wojdyla JA, Panjikar S, Snijder EJ, Gorbalenya
#=GF RA   AE, Berglind H, Nordlund P, Coutard B, Tucker PA;
#=GF RL   Acta Crystallogr D Biol Crystallogr. 2009;65:839-846.
#=GF RN   [2]
#=GF RM   28738245
#=GF RT   Two-amino acids change in the nsp4 of SARS coronavirus abolishes
#=GF RT   viral replication.
#=GF RA   Sakai Y, Kawachi K, Terada Y, Omori H, Matsuura Y, Kamitani W;
#=GF RL   Virology. 2017;510:165-174.
#=GF RN   [3]
#=GF RM   29162711
#=GF RT   Expression and Cleavage of Middle East Respiratory Syndrome
#=GF RT   Coronavirus nsp3-4 Polyprotein Induce the Formation of
#=GF RT   Double-Membrane Vesicles That Mimic Those Associated with
#=GF RT   Coronaviral RNA Replication.
#=GF RA   Oudshoorn D, Rijs K, Limpens RWAL, Groen K, Koster AJ, Snijder
#=GF RA   EJ, Kikkert M, Barcena M;
#=GF RL   mBio. 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR032505;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the C-terminal domain of the coronavirus nonstructural
#=GF CC   protein 4 (NSP4). NSP4 is encoded by ORF1a/1ab and
#=GF CC   proteolytically released from the pp1a/1ab polyprotein. It is a
#=GF CC   membrane-spanning protein which is thought to anchor the viral
#=GF CC   replication-transcription complex (RTC) to modified endoplasmic
#=GF CC   reticulum membranes. This predominantly alpha-helical domain may
#=GF CC   be involved in protein-protein interactions [1]. It has been
#=GF CC   shown that in Betacoronavirus, the coexpression of NSP3 and NSP4
#=GF CC   results in a membrane rearrangement to induce double-membrane
#=GF CC   vesicles (DMVs) and convoluted membranes (CMs), playing a
#=GF CC   critical role in SARS-CoV replication. There are two well
#=GF CC   conserved amino acid residues (H120 and F121) in NSP4 among
#=GF CC   Betacoronavirus, essential for membrane rearrangements during
#=GF CC   interaction with NSP3 [2,3].
#=GF SQ   111
#=GS A0A1B3Q5W8_9BETC/3053-3146  AC A0A1B3Q5W8.1
#=GS A0A0U1WHG0_SARS/3138-3234   AC A0A0U1WHG0.1
#=GS A0A0A7UXR0_9BETC/3196-3292  AC A0A0A7UXR0.1
#=GS R1A_SARS/3143-3239          AC P0C6U8.1
#=GS A0A0U1UZ65_BCHK4/3203-3298  AC A0A0U1UZ65.1
#=GS H9AA60_9BETC/3170-3266      AC H9AA60.1
#=GS A0A0K2RW65_9BETC/3184-3280  AC A0A0K2RW65.1
#=GS H9BZX6_9BETC/3237-3333      AC H9BZX6.1
#=GS R1AB_BCHK4/3195-3290        AC P0C6W3.1
#=GS Q9J3E9_9BETC/3233-3329      AC Q9J3E9.1
#=GS R1A_BCHK9/3009-3102         AC P0C6T6.1
#=GS V5TFR4_9GAMC/2663-2757      AC V5TFR4.1
#=GS B1PHI6_9ALPC/3108-3203      AC B1PHI6.1
#=GS R1AB_CVH22/2870-2965        AC P0C6X1.1
#=GS H9BR34_9NIDO/2315-2407      AC H9BR34.1
#=GS A0A0U1WHG1_9ALPC/2720-2815  AC A0A0U1WHG1.1
#=GS B1PHK1_9ALPC/3015-3110      AC B1PHK1.1
#=GS E0XIZ2_9BETC/3134-3230      AC E0XIZ2.1
#=GS Q06BE1_9BETC/3149-3245      AC Q06BE1.2
#=GS U5KNA9_9BETC/3214-3309      AC U5KNA9.1
#=GS A0A0K1YZY7_SARS/3143-3239   AC A0A0K1YZY7.1
#=GS D9J203_9ALPC/2771-2866      AC D9J203.1
#=GS A3EXI9_BCHK9/3004-3097      AC A3EXI9.1
#=GS R1AB_CVM2/3182-3278         AC P0C6X8.1
#=GS R1AB_BCHK9/3009-3102        AC P0C6W5.1
#=GS A0A0U1UZC3_9ALPC/2775-2870  AC A0A0U1UZC3.1
#=GS R1A_BCHK4/3195-3290         AC P0C6T4.1
#=GS F2YDB2_SARS/3143-3239       AC F2YDB2.1
#=GS S5Z1D1_9ALPC/2946-3041      AC S5Z1D1.1
#=GS A0A140ESF0_9NIDO/2412-2504  AC A0A140ESF0.1
#=GS A0A0U1UZA8_9ALPC/3051-3146  AC A0A0U1UZA8.1
#=GS H9TEW9_9ALPC/2784-2879      AC H9TEW9.1
#=GS A0A125R5A4_9ALPC/2795-2890  AC A0A125R5A4.1
#=GS B2BW32_9GAMC/2663-2757      AC B2BW32.1
#=GS A0A0U1WHG4_9ALPC/2861-2956  AC A0A0U1WHG4.1
#=GS A0A0K1Z0N1_SARS/3143-3239   AC A0A0K1Z0N1.1
#=GS R1A_BCHK5/3242-3337         AC P0C6T5.1
#=GS E0ZN59_BCHK9/2982-3077      AC E0ZN59.1
#=GS A0A059VJE6_9ALPC/2902-2997  AC A0A059VJE6.1
#=GS R1A_BC512/2917-3012         AC P0C6F6.1
#=GS R1AB_IBVB/2684-2778         AC P0C6Y1.1
#=GS E0ZN51_BCHK9/3004-3097      AC E0ZN51.1
#=GS B8Q8U7_SARS/3143-3239       AC B8Q8U7.1
#=GS R1A_IBVB/2684-2778          AC P0C6V3.1
#=GS Q0PL14_9ALPC/2780-2875      AC Q0PL14.1
#=GS R1AB_SARS2/3166-3262        AC P0DTD1.1
#=GS Q6UZF5_SARS/3143-3239       AC Q6UZF5.1
#=GS H9BR07_9NIDO/2400-2492      AC H9BR07.1
#=GS R1A_SARS2/3166-3262         AC P0DTC1.1
#=GS R1AB_CVMA5/3236-3332        AC P0C6X9.1
#=GS R1AB_CVMA5/3236-3332        DR PDB; 3VC8 B; 1-85;
#=GS R1AB_CVMA5/3236-3332        DR PDB; 3VCB A; 1-88;
#=GS R1AB_CVMA5/3236-3332        DR PDB; 3VC8 A; 1-81;
#=GS R1AB_CVMA5/3236-3332        DR PDB; 3VCB B; 1-88;
#=GS B8Q8S4_SARS/3143-3239       AC B8Q8S4.1
#=GS R1A_CVM2/3182-3278          AC P0C6U9.1
#=GS B1PHJ3_9ALPC/3052-3147      AC B1PHJ3.1
#=GS Q0ZJB1_CVHK1/3237-3332      AC Q0ZJB1.1
#=GS B1PHK0_9ALPC/3015-3110      AC B1PHK0.1
#=GS R1AB_FIPV/2808-2903         AC Q98VG9.2
#=GS R1AB_FIPV/2808-2903         DR PDB; 3GZF C; 1-91;
#=GS R1AB_FIPV/2808-2903         DR PDB; 3GZF B; 1-95;
#=GS R1AB_FIPV/2808-2903         DR PDB; 3GZF E; 1-89;
#=GS R1AB_FIPV/2808-2903         DR PDB; 3GZF A; 1-95;
#=GS R1AB_FIPV/2808-2903         DR PDB; 3GZF D; 1-91;
#=GS T2B9U0_MERS/3151-3246       AC T2B9U0.1
#=GS C0KYZ6_9BETC/3239-3335      AC C0KYZ6.1
#=GS A0A0U2UMS4_9ALPC/2781-2876  AC A0A0U2UMS4.1
#=GS A3EXA2_BCHK4/3195-3290      AC A3EXA2.1
#=GS S5YAF0_9ALPC/2946-3041      AC S5YAF0.1
#=GS R1A_CVPPU/2783-2878         AC P0C6V2.1
#=GS A0A0U1UZ20_9ALPC/3015-3110  AC A0A0U1UZ20.1
#=GS A3EXC0_BCHK4/3205-3300      AC A3EXC0.1
#=GS B7U2M9_9BETC/3149-3245      AC B7U2M9.1
#=GS R1A_CVMA5/3236-3332         AC P0C6V0.1
#=GS R1A_CVMJH/3239-3335         AC P0C6V1.1
#=GS A0A1X9JQL5_9ALPC/2756-2851  AC A0A1X9JQL5.1
#=GS R9QTB2_SARS/3135-3231       AC R9QTB2.1
#=GS A0A0P0ILY9_CVH22/2875-2970  AC A0A0P0ILY9.1
#=GS A0A0K1RLM9_9ALPC/2779-2874  AC A0A0K1RLM9.1
#=GS R1AB_BC512/2917-3012        AC P0C6W0.1
#=GS R1A_CVHOC/3149-3245         AC P0C6U7.1
#=GS D9J202_9ALPC/2771-2866      AC D9J202.1
#=GS B1PHJ4_9ALPC/3052-3147      AC B1PHJ4.1
#=GS H9BZX5_9BETC/3237-3333      AC H9BZX5.1
#=GS A0A240FW17_9ALPC/2470-2565  AC A0A240FW17.1
#=GS A0A0P0LKV0_CVH22/2875-2970  AC A0A0P0LKV0.1
#=GS B2BW31_9GAMC/2663-2757      AC B2BW31.1
#=GS R1AB_CVMJH/3239-3335        AC P0C6Y0.1
#=GS R1AB_BCHK5/3242-3337        AC P0C6W4.1
#=GS R1AB_SARS/3143-3239         AC P0C6X7.1
#=GS R1AB_SARS/3143-3239         DR PDB; 2Q6G D; 1-5;
#=GS R1AB_SARS/3143-3239         DR PDB; 4ZUH C; 1-4;
#=GS R1AB_SARS/3143-3239         DR PDB; 2Q6G C; 1-5;
#=GS A0A0F6SKM6_9GAMC/2713-2807  AC A0A0F6SKM6.1
#=GS A0A0K2RVJ3_9BETC/3184-3280  AC A0A0K2RVJ3.1
#=GS A8JNZ1_9ALPC/2846-2941      AC A8JNZ1.1
#=GS A0A0U1WHD1_9ALPC/3008-3103  AC A0A0U1WHD1.1
#=GS F2YDB1_SARS/3143-3239       AC F2YDB1.1
#=GS R1A_BC279/3149-3245         AC P0C6F5.1
#=GS R1AB_CVPPU/2783-2878        AC P0C6Y5.1
#=GS A8JNZ0_9ALPC/2846-2941      AC A8JNZ0.1
#=GS B8Q8U6_SARS/3143-3239       AC B8Q8U6.1
#=GS A0A0F6WGL5_9GAMC/2713-2807  AC A0A0F6WGL5.1
#=GS A0A125R5A3_9ALPC/2795-2890  AC A0A125R5A3.1
#=GS B1PHI7_9ALPC/3108-3203      AC B1PHI7.1
#=GS U5LR11_9BETC/3214-3309      AC U5LR11.1
#=GS H9TEX0_9ALPC/2784-2879      AC H9TEX0.1
#=GS A0A096XNJ3_9ALPC/2860-2955  AC A0A096XNJ3.2
#=GS A0A088DIE1_9BETC/3308-3403  AC A0A088DIE1.1
#=GS A0A0U1WHK4_SARS/3143-3239   AC A0A0U1WHK4.1
#=GS R1AB_CVHOC/3149-3245        AC P0C6X6.1
#=GS K4K1U5_9ALPC/2902-2997      AC K4K1U5.1
#=GS A3EXE7_BCHK5/3241-3336      AC A3EXE7.1
#=GS B6VDX7_THCOV/2391-2483      AC B6VDX7.1
#=GS H9BQZ9_9NIDO/2422-2514      AC H9BQZ9.1
#=GS A0A023YA54_MERS/3252-3347   AC A0A023YA54.1
#=GS R1AB_BC279/3149-3245        AC P0C6V9.1
#=GS R1A_CVH22/2870-2965         AC P0C6U2.1
#=GS T2B9I2_MERS/3151-3246       AC T2B9I2.1
#=GS H9BR24_9NIDO/2369-2464      AC H9BR24.1
#=GS B8Q8S5_SARS/3143-3239       AC B8Q8S5.1
#=GS H9BR16_9NIDO/2396-2487      AC H9BR16.1
A0A1B3Q5W8_9BETC/3053-3146             .vgdlsf--------..HSFHDAALQTFMLDKEKFLRLKRE..LSPDAYAKYLALFPKYKYYNGPMDTAAYREAACAHLVMALEKFS.TGG..GDSIYQPPRCSVAAA--tl..
A0A0U1WHG0_SARS/3138-3234              .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
A0A0A7UXR0_9BETC/3196-3292             .....lh--TGIRSD..GTFEEMSLTTFMINKDTYCKLKNS..LSEVAFNKYLSLYNKYRYYSGKMDTAAYREAACSQLAKALDTFNhNNG..NDVLYQPPTASVSTSF-l...
R1A_SARS/3143-3239                     .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
A0A0U1UZ65_BCHK4/3203-3298             ....vft---DGKLN..CSFQDAASNIFVIGKDTYVALRNA..ITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS.ETG..SDILYQPPNCSVTSSV-l...
H9AA60_9BETC/3170-3266                 ....lgt---GVRSD..GTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLGLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
A0A0K2RW65_9BETC/3184-3280             ...lgts------VRsdGTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
H9BZX6_9BETC/3237-3333                 ......l---GTEVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMDTFNhNNG..NDVLYQPPTASVTTSF-l...
R1AB_BCHK4/3195-3290                   ....vft---DGKLN..CSFQDAASNIFVIGKDTYVALRNA..ITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS.ETG..SDILYQPPNCSVTSSV-l...
Q9J3E9_9BETC/3233-3329                 ......i---GTEVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
R1A_BCHK9/3009-3102                    .vgdlaf--------..HSFQDAALQTFMLDKEVFLRLKRE..ISSDAYFKYLAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYS.NGG..GDTIYQPPRCSVASA--al..
V5TFR4_9GAMC/2663-2757                 .......LFEKGEFV..ADFDTAARSTFLINNSVYVKLVNE..VG-DKFQKYLSGYARLKYYSGSGGDQECLDACRATLANALENFK.NTQ..VEVLYTPPRFGVN----lvtr
B1PHI6_9ALPC/3108-3203                 .......LFEGDKFV..GTFENAAFGTFVIDMHSYEKLVNS..ITPEKLKQHASMFNKYKYYSGSASEADYRCACFAHLAKAMTDYA.ANH..QDMLYSPPSISYNSTLQ....
R1AB_CVH22/2870-2965                   .......LFEGDKFV..GTFESAAAGTFVIDMRSYEKLANS..ISPEKLKSYAASYNRYKYYSGNANEADYRCACYAYLAKAMLDFS.RDH..NDILYTPPTVSYGSTLQ....
H9BR34_9NIDO/2315-2407                 ..ktkgk------F-..SSFLDAAKSTFVIDNDKYVLLKDL..AG-PDYDQYLASYVKYKYFTGTASDKDYDKVCMAFLAKAMSLFR.EGG..GTQLYTPPKLAVVQSI-k...
A0A0U1WHG1_9ALPC/2720-2815             .......LFDGDKFV..GSFEAAAMGTFVLDMHSYEKLVNS..LPADKLKQYASAFNRYKYYSGSASEADYRLACFSHLAKAMMDYG.TTH..QDCLYTPPTISYNSTLQ....
B1PHK1_9ALPC/3015-3110                 .......LFEGDKFV..GTFETAAYGTFVLDMRSYEKLVNS..MPMDKIKQYAATYNKYKYYSGSASEADYRCACFAHLAKALLAYA.DNH..QDLLYTPPSVSYNSTLQ....
E0XIZ2_9BETC/3134-3230                 .......VFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
Q06BE1_9BETC/3149-3245                 ...lgts------VRsdGTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
U5KNA9_9BETC/3214-3309                 ....vft---DGKLN..CTFQEAAANIFVVNRDTYVALRNA..ISQDAYNKYLGMFNKYKYFSGVMDTAAYREASAAHLAKALQVFS.ENG..SDLLYQPPNCSLASSV-l...
A0A0K1YZY7_SARS/3143-3239              .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..SDVLYQPPQTSITSAV-l...
D9J203_9ALPC/2771-2866                 .......LFEGDKFV..GNFESAAAGTFVIDMRSYETIVNS..IPMERLKGYAATFNKYKYYTGSMGESDYRLACYAHLARALLDYS.ANR..NDILYTPPTVSVNSTLQ....
A3EXI9_BCHK9/3004-3097                 .vgdlaf--------..HSFQDAALQTFMLDKEVFLRLKRE..ISSDAYSKYLAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYS.NGG..GDTIYQPPRCSVASA--al..
R1AB_CVM2/3182-3278                    ......l---GTEVRsdGTFEEMSLTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
R1AB_BCHK9/3009-3102                   .vgdlaf--------..HSFQDAALQTFMLDKEVFLRLKRE..ISSDAYFKYLAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYS.NGG..GDTIYQPPRCSVASA--al..
A0A0U1UZC3_9ALPC/2775-2870             .......LFEDGNFI..GNFESAAAGTFVLDMRTYEKLVNS..IPAERLRQYAASYMKYKYYSGSPGEVDYRLACYAHLAHAMMSFG.KDQ..RDVLYTPPTVSFNSTLQ....
R1A_BCHK4/3195-3290                    ....vft---DGKLN..CSFQDAASNIFVIGKDTYVALRNA..ITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS.ETG..SDILYQPPNCSVTSSV-l...
F2YDB2_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
S5Z1D1_9ALPC/2946-3041                 .......LFDGEKFV..GSFETAAMGTFVLDMRTYEKLVNS..TPGDKIRQYAATYNKYKYYSGGANEADYRLACFAHLAKAMMDFG.SNH..QDMLYSPPTVSYNSTLQ....
A0A140ESF0_9NIDO/2412-2504             ..ktagk------F-..SSFLDAAKATFVIDNEKYVLLKDL..AG-AEFDQYLASYNKYKYFSGTASDKDYDKVCMAFLAKALSSFR.EGG..GSQLYTPPKFAVVQSL-k...
A0A0U1UZA8_9ALPC/3051-3146             .......LFEGDKFV..GTFENAAFGTFVIDMHSYEKLVNS..ITPDKLKQHAAMFNKYKYYSGSASEADYRCACFAHLAKAMTDYA.SSH..QDMLYSPPSISYNSTLQ....
H9TEW9_9ALPC/2784-2879                 .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..TPIERIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
A0A125R5A4_9ALPC/2795-2890             .......LFEGDKFV..GSFESAAMGTFVIDMRSYETLVNS..TSLDRIKSYAGSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VSR..NDMLYTPPTVSVNSTLQ....
B2BW32_9GAMC/2663-2757                 .......LFEKGEFV..ADFDTAARSTFLINNSVYVKLVNE..VG-DKFQKYLSGYARLKYYSGSGGDQECLDACRATLANALENFK.NTQ..VEVLYTPPRFGVN----lvtr
A0A0U1WHG4_9ALPC/2861-2956             .......LFDGDKFV..GNFENAAFGTFVMDMHSYQRLVNS..IAPEKLKQYAASYNKYKYYSGSASEADYRLACYAHLAKAMLDYS.SNH..NDILYTPPTISYNSTLQ....
A0A0K1Z0N1_SARS/3143-3239              .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..SDVLYQPPQTSITSAV-l...
R1A_BCHK5/3242-3337                    ....vft---DGKLN..CSFQDAAANIFVINKDTYVALRNS..ITQDSYNRYLSMFNKYKYYSGAMDTASYREASAAHLCKALQVYS.ETG..SDVLFQPPNCSVTSSV-l...
E0ZN59_BCHK9/2982-3077                 ....vhv---GDLVF..HSFQDAALQTFMLDKEVFLRLKRE..ISSDAYAKYLAMYNKYKYYSGPMDTSAYREAACSHLVMALEKYS.NGG..GDTIYQPPRCSVASA--al..
A0A059VJE6_9ALPC/2902-2997             .......LFEGDKFV..GSFENAAAGTFVLDMHAYERLANS..ISTEKLRQYASTYNKYKYYSGSASEADYRLACFAHLAKAMMDYA.SNH..NDTLYTPPTVSYNSTLQ....
R1A_BC512/2917-3012                    .......LFEGDKFV..GSFESAASGTFVLDMHSYQKLANS..ISTEKLKQYCASYNRYKYYSGSASEADYRLACFAHLAKAMSDFA.NDH..MDKLYTPPTVSYNSTLQ....
R1AB_IBVB/2684-2778                    .......LYDGNEFV..GNYDLAAKSTFVIRGSEFVKLTNE..IG-DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYR.NSG..VEIVYTPPRYSIGVS--rl..
E0ZN51_BCHK9/3004-3097                 .vgdlaf--------..HSFQDAALQTFMLDKEVFLRLKRE..ISSDAYAKYLAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYS.NGG..GDTIYQPPRCSVASA--al..
B8Q8U7_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
R1A_IBVB/2684-2778                     .......LYDGNEFV..GNYDLAAKSTFVIRGSEFVKLTNE..IG-DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYR.NSG..VEIVYTPPRYSIGVS--rl..
Q0PL14_9ALPC/2780-2875                 .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..IPIDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
R1AB_SARS2/3166-3262                   .......VFNGVSF-..STFEEAALCTFLLNKEMYLKLRSDvlLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFS.NSG..SDVLYQPPQTSITSAV-l...
Q6UZF5_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
H9BR07_9NIDO/2400-2492                 .....kt---GGKF-..SSFLDASKSTFVIDNDKYVLLRDL..AG-NDFDAYLASYNKYKYFSGTASDKDYDKVCMAFLAKALSSFR.EGG..GSQLYTPPKLAVV----qgvv
R1A_SARS2/3166-3262                    .......VFNGVSF-..STFEEAALCTFLLNKEMYLKLRSDvlLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFS.NSG..SDVLYQPPQTSITSAV-l...
R1AB_CVMA5/3236-3332                   ......i---GTEVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
#=GR R1AB_CVMA5/3236-3332        SS    ......X---XXXXXXXXHHHHHTTS-EEE-HHHHHHHHHH..S-HHHHHHHHHCHHHHCT-ECEEEHHHHHHHHHHHHHHHHHHHHCTTS..--EEE--SEEEEEEE---...
B8Q8S4_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
R1A_CVM2/3182-3278                     ......l---GTEVRsdGTFEEMSLTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
B1PHJ3_9ALPC/3052-3147                 .......LFEGDKFV..GTFENAAFGTFVIDMHSYEKLVNS..ITPDKLKQHAAMFNKYKYYSGSASEADYRCACFAHLAKAMTDYA.SSH..QDMLYSPPSISYNSTLQ....
Q0ZJB1_CVHK1/3237-3332                 gvnvcnd--------..STFEETSLTTFMITKDSYCRLKNS..VSDVAYNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVSTSF-l...
B1PHK0_9ALPC/3015-3110                 .......LFEGDKFV..GTFETAAYGTFVLDMRSYEKLVNS..MPMDKIKQYAATYNKYKYYSGSASEADYRCACFAHLAKALLAYA.DNH..QDLLYTPPSVSYNSTLQ....
R1AB_FIPV/2808-2903                    .......LFEGDKFV..GSFESAAMGTFVIDMRSYETLVNS..TSLDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VSR..NDMLYTPPTVSVNSTLQ....
#=GR R1AB_FIPV/2808-2903         SS    .......-EETTEE-..--HHHHHHS-EEE-HHHHHHHHTT..T-HHHHHHHHHTHHHHHS-EEE--HHHHHHHHHHHHHHHHHHHH.HS-..--EEE---EEEEEXXXX....
T2B9U0_MERS/3151-3246                  ....vft---DGKLN..CSFQDAASNIFVINKDTYAALRNS..LTNDAYSRFLGLFNKYKYFSGAMETAAYREAAACHLAKALQTYS.ETG..SDLLYQPPNCSITSGV-l...
C0KYZ6_9BETC/3239-3335                 .....ig----TDVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
A0A0U2UMS4_9ALPC/2781-2876             .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..TPIDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
A3EXA2_BCHK4/3195-3290                 ....vft---DGKLN..CSFQDAASNIFVIGKDTYVALRNA..ITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS.ETG..SDILYQPPNCSVTSSV-l...
S5YAF0_9ALPC/2946-3041                 .......LFDGEKFV..GSFETAAMGTFVLDMRTYEKLVNS..TPGDKIRQYAATYNKYKYYSGGANEADYRLACFAHLAKAMMDFG.SNH..QDMLYSPPTVSYNSTLQ....
R1A_CVPPU/2783-2878                    .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..TSIARIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
A0A0U1UZ20_9ALPC/3015-3110             .......LFEGDKFV..GTFETAAYGTFVLDMRSYEKLVNS..MPMDKIKQYAATYNKYKYYSGSASEADYRCACFAHLAKALLAYA.DNH..QDLLYTPPSVSYNSTLQ....
A3EXC0_BCHK4/3205-3300                 ....vft---DGKLN..CSFQDAASNIFVIGKDTYVALRNA..ITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS.ETG..SDILYQPPNCSVTSSV-l...
B7U2M9_9BETC/3149-3245                 ...lgts------VRsdGTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
R1A_CVMA5/3236-3332                    ......i---GTEVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
R1A_CVMJH/3239-3335                    .....ig----TDVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTATYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
A0A1X9JQL5_9ALPC/2756-2851             .......LLEGDKFV..GSFEHASRGTFVLNAQSCAKLVNE..IGQEKLDRYAANYARYRHYSGNPNEADYRAACFAWLAKAIKDYQ.LSP..QDKLYCAPTVSYNSVLQ....
R9QTB2_SARS/3135-3231                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
A0A0P0ILY9_CVH22/2875-2970             .......LFEGDKFV..GTFESAAAGTFVLDMRSYEKLANS..ISPDKLKSYAASYNRYKYYSGNASEADYRCACYAYLAKAMMDYS.RDH..NDILYTPPTVSYGSTLQ....
A0A0K1RLM9_9ALPC/2779-2874             .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..TPIDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
R1AB_BC512/2917-3012                   .......LFEGDKFV..GSFESAASGTFVLDMHSYQKLANS..ISTEKLKQYCASYNRYKYYSGSASEADYRLACFAHLAKAMSDFA.NDH..MDKLYTPPTVSYNSTLQ....
R1A_CVHOC/3149-3245                    ...lgts------VRsdGTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
D9J202_9ALPC/2771-2866                 .......LFEGDKFV..GNFESAAAGTFVIDMRSYETIVNS..IPMERLKGYAATFNKYKYYTGSMGESDYRLACYAHLARALLDYS.ANR..NDILYTPPTVSVNSTLQ....
B1PHJ4_9ALPC/3052-3147                 .......LFEGDKFV..GTFENAAFGTFVIDMHSYEKLVNS..ITPDKLKQHAAMFNKYKYYSGSASEADYRCACFAHLAKAMTDYA.SSH..QDMLYSPPSISYNSTLQ....
H9BZX5_9BETC/3237-3333                 ......l---GTEVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQLAKAMDTFNhNNG..NDVLYQPPTASVTTSF-l...
A0A240FW17_9ALPC/2470-2565             .......LYEGEVFV..GTFDSASQATFLLNKDTYVKLVNS..LSRDKLEYYASKYNQYKYYQGSGKDGEYLLACKTHLAKALADFA.NSQ..VDVVYLPPTVTFTSRM-q...
A0A0P0LKV0_CVH22/2875-2970             .......LFEGDKFV..GTFESAAAGTFVLDMRSYEKLANS..ISPDKLKSYAASYNRYKYYSGNASEADYRCACYAYLAKAMMDYS.RDH..NDILYTPPTVSYGSTLQ....
B2BW31_9GAMC/2663-2757                 .......LFEKGEFV..ADFDTAARSTFLINNSVYVKLVNE..VG-DKFQKYLSGYARLKYYSGSGGDQECLDACRATLANALENFK.NTQ..VEVLYTPPRFGVN----lvtr
R1AB_CVMJH/3239-3335                   .....ig----TDVRsdGTFEEMALTTFMITKESYCKLKNS..VSDVAFNRYLSLYNKYRYFSGKMDTATYREAACSQLAKAMETFNhNNG..NDVLYQPPTASVTTSF-l...
R1AB_BCHK5/3242-3337                   ....vft---DGKLN..CSFQDAAANIFVINKDTYVALRNS..ITQDSYNRYLSMFNKYKYYSGAMDTASYREASAAHLCKALQVYS.ETG..SDVLFQPPNCSVTSSV-l...
R1AB_SARS/3143-3239                    .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
#=GR R1AB_SARS/3143-3239         SS    .......XXXXXXX-..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX..XXXXXXXXXXXX---E-E...
A0A0F6SKM6_9GAMC/2713-2807             .......LYEGNEFV..GSYDLAAQSTFVIRNVEFVKLSNE..VG-EKLDVYLSAYARLKYYSGTGGEQDYLHACRAWLAYALDQYR.ANG..VEVLYTPPKFSMGVS--rl..
A0A0K2RVJ3_9BETC/3184-3280             ...lgts------VRsdGTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
A8JNZ1_9ALPC/2846-2941                 .......LFEGTKFV..GTFDAASVGTFVIDARSYERLINS..TSIEKIKQYASTFNKYKYYSGSANEADYRCACYAHLAKALIDFS.TTR..QDTLYTPPTVSINSTLQ....
A0A0U1WHD1_9ALPC/3008-3103             .......LFEGDKFV..GSFEAAAYGTFVLDMRSYERIVNS..ISMDKIKQYAATYNKYKYYSGSASEADYRCACFAHLAKALLTYA.DNH..QDLLYTPPSISYNSTLQ....
F2YDB1_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
R1A_BC279/3149-3245                    .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
R1AB_CVPPU/2783-2878                   .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..TSIARIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
A8JNZ0_9ALPC/2846-2941                 .......LFEGTKFV..GTFDAASVGTFVIDARSYERLINS..TSIEKIKQYASTFNKYKYYSGSANEADYRCACYAHLAKALIDFS.TTR..QDTLYTPPTVSINSTLQ....
B8Q8U6_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
A0A0F6WGL5_9GAMC/2713-2807             .......LYEGNEFV..GSYDLAAQSTFVIRNVEFVKLSNE..VG-EKLDVYLSAYARLKYYSGTGGEQDYLHACRAWLAYALDQYR.ANG..VEVLYTPPKFSMGVS--rl..
A0A125R5A3_9ALPC/2795-2890             .......LFEGDKFV..GSFESAAMGTFVIDMRSYETLVNS..TSLDRIKSYAGSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VSR..NDMLYTPPTVSVNSTLQ....
B1PHI7_9ALPC/3108-3203                 .......LFEGDKFV..GTFENAAFGTFVIDMHSYEKLVNS..ITPEKLKQHASMFNKYKYYSGSASEADYRCACFAHLAKAMTDYA.ANH..QDMLYSPPSISYNSTLQ....
U5LR11_9BETC/3214-3309                 ....vft---DGKLN..CTFQEAAANIFVVNRDTYVALRNA..ISQDAYNKYLGMFNKYKYFSGVMDTAAYREASAAHLAKALQVFS.ENG..SDLLYQPPNCSLASSV-l...
H9TEX0_9ALPC/2784-2879                 .......LFEGDKFV..GNFESAAMGTFVIDMRSYETIVNS..TPIERIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS.VNR..TDMLYTPPTVSVNSTLQ....
A0A096XNJ3_9ALPC/2860-2955             .......LLEGDKFV..GSFEHASRGTFVLNAHSCAKLVNE..IGQEKLDRYASSYARYRHYSGNPNEADYRAACFAWLAKAIKDYQ.MSP..QDKLYCAPTVSYNSVLQ....
A0A088DIE1_9BETC/3308-3403             ..vhdat------F-..SSFAEAALSTFMITRDVYVKLRAEafLSAAQYNRYLSMFNRYKYFSGSMDTESYREAACCHLAKAMKDFS.EQG..SDILYQPPSCSLASAV-l...
A0A0U1WHK4_SARS/3143-3239              .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
R1AB_CVHOC/3149-3245                   ...lgts------VRsdGTFEEMALTTFMITKDSYCKLKNS..LSDVAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTnNNG..SDVLYQPPTASVSTSF-l...
K4K1U5_9ALPC/2902-2997                 .......LFDGDKFV..GNFETAATGTFVLDMHSYQRIVNS..IAPEKIKQHAASYNKYKYYSGAASEADYRLACYAHLAKAVLDYG.TNH..QDTLYTPPTISYNSTLQ....
A3EXE7_BCHK5/3241-3336                 ....vft---DGKLN..CSFQDAAANIFVINKDTYVALRNS..ITQDSYNRYLSMFNKYKYYSGAMDTASYREASAAHLCKALQVYS.ETG..SDVLFQPPNCSVTSSV-l...
B6VDX7_THCOV/2391-2483                 ..ktagk------F-..SSFLGASKATFVIDNDKYVMLRDL..AG-SEYDSYLASYNKYKYFSGTASDKDYDKVCMAFLAKALSSFR.DGG..GSQLYTPPQLAVVQSI-k...
H9BQZ9_9NIDO/2422-2514                 ..ktagk------F-..SSFLDAAKSTFVIDNEKYVLLRDL..AG-SEFDQYLASYNKYKYFSGTASDKDYDKVCMAFLAKALSSFR.EGG..GSQLYTPPKFAVVQSL-k...
A0A023YA54_MERS/3252-3347              ....vft---DGKLN..CTFQEAAANIFVVNKDTYVALRNS..INADVYARYLAMFNKYKYFSGAMDTAAYREAAASHLAKALQTYS.ETG..SDLLYQPPNCSITSGV-l...
R1AB_BC279/3149-3245                   .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
R1A_CVH22/2870-2965                    .......LFEGDKFV..GTFESAAAGTFVIDMRSYEKLANS..ISPEKLKSYAASYNRYKYYSGNANEADYRCACYAYLAKAMLDFS.RDH..NDILYTPPTVSYGSTLQ....
T2B9I2_MERS/3151-3246                  ....vft---DGKLN..CSFQDAASNIFVINKDTYAALRNS..LTNDAYSRFLGLFNKYKYFSGAMETAAYREAAACHLAKALQTYS.ETG..SDLLYQPPNCSITSGV-l...
H9BR24_9NIDO/2369-2464                 stgradf--------..TSFSAASKSTFVIDTKKYVELMNL..AG-SDFDAYLASYAKYRYYSGAADTSEYSKVCIAFLAKALDSFK.AAGgtGSVLYTPPKLAVV----qsgi
B8Q8S5_SARS/3143-3239                  .......MFNGVTF-..STFEEAALCTFLLNKEMYLKLRSEtlLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS.NSG..ADVLYQPPQTSITSAV-l...
H9BR16_9NIDO/2396-2487                 .tasggf--------..KTFLDASKATFVISNDKYVEMLNL..AG-SEYDTYLASYARYRYYSGTTDSAEYNKVCMAFLAKALDNFK.TSG..GSVLYTPPKLTVV----qag.
#=GC SS_cons                           .......XEETTEE-..XHHHHHCCSXEEEXHHHHHHHHCCXXTXHHHHHHHHHCHHHHCTXECEEEHHHHHHHHHHHHHHHHHHHHCCTS..XXEEEXXSEEEEEEEE-E...
#=GC seq_cons                          ..........GscF...uoFEpAAhsTFllspcoYh+LpNu..ls.spaspYLuhYNKYKYYSGuhssAsYRcAshuHLAKALpsau.ssG..sDlLYpPPssSlsSol.h...
//
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