GenomeNet

Database: Pfam
Entry: CoV_NSP6
LinkDB: CoV_NSP6
Original site: CoV_NSP6 
#=GF ID   CoV_NSP6
#=GF AC   PF19213.2
#=GF DE   Coronavirus replicase NSP6
#=GF PI   DUF5881;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF SE   Jackhmmer:P0DTC1
#=GF GA   25.00 25.00;
#=GF TC   114.80 114.80;
#=GF NC   24.00 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   19386712
#=GF RT   Detection of nonstructural protein 6 in murine
#=GF RT   coronavirus-infected cells and analysis of the transmembrane
#=GF RT   topology by using bioinformatics and molecular approaches.
#=GF RA   Baliji S, Cammer SA, Sobral B, Baker SC;
#=GF RL   J Virol. 2009;83:6957-6962.
#=GF RN   [2]
#=GF RM   24991833
#=GF RT   Coronavirus NSP6 restricts autophagosome expansion.
#=GF RA   Cottam EM, Whelband MC, Wileman T;
#=GF RL   Autophagy. 2014;10:1426-1441.
#=GF RN   [3]
#=GF RM   21799305
#=GF RT   Coronavirus nsp6 proteins generate autophagosomes from the
#=GF RT   endoplasmic reticulum  via an omegasome intermediate.
#=GF RA   Cottam EM, Maier HJ, Manifava M, Vaux LC, Chandra-Schoenfelder
#=GF RA   P, Gerner W, Britton P, Ktistakis NT, Wileman T;
#=GF RL   Autophagy. 2011;7:1335-1347.
#=GF DR   INTERPRO; IPR043610;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents proteins found in Coronaviruses and
#=GF CC   includes the Non-structural Protein 6 (NSP6). Coronaviruses
#=GF CC   encode large replicase polyproteins which are proteolytically
#=GF CC   processed by viral proteases to generate mature Nonstructural
#=GF CC   Proteins (NSPs) [1]. NSP6 is a membrane protein containing 6
#=GF CC   transmembrane domains with a large C-terminal tail [1]. NSP6
#=GF CC   from  the avian coronavirus, infectious bronchitis  virus (IBV)
#=GF CC   and the mouse hepatitis virus (MHV) have been shown  to localise
#=GF CC   to the ER and to generate autophagosomes [2].  Coronavirus NSP6
#=GF CC   proteins have also been shown to limit  autophagosome expansion.
#=GF CC   This may favour coronavirus infection  by reducing the ability
#=GF CC   of autophagosomes to deliver viral  components to lysosomes for
#=GF CC   degradation [2]. NSP6 from IBV, MHV  and severe acute
#=GF CC   respiratory syndrome coronavirus (SARS-CoV)  have also been
#=GF CC   found to activate autophagy [2,3].
#=GF SQ   111
#=GS R1A_SARS2/3597-3859         AC P0DTC1.1
#=GS A0A0U1WHG4_9ALPC/3283-3537  AC A0A0U1WHG4.1
#=GS A0A096XNJ3_9ALPC/3282-3541  AC A0A096XNJ3.2
#=GS E0XIZ2_9BETC/3565-3827      AC E0XIZ2.1
#=GS R1AB_CVHOC/3577-3836        AC P0C6X6.1
#=GS R1AB_IBVB/3110-3379         AC P0C6Y1.1
#=GS A0A0U2UMS4_9ALPC/3203-3472  AC A0A0U2UMS4.1
#=GS K4K1U5_9ALPC/3324-3575      AC K4K1U5.1
#=GS R1A_CVMA5/3663-3921         AC P0C6V0.1
#=GS E0ZN51_BCHK9/3432-3694      AC E0ZN51.1
#=GS R1A_IBVB/3110-3379          AC P0C6V3.1
#=GS H9BZX5_9BETC/3665-3924      AC H9BZX5.1
#=GS R1AB_BC512/3339-3590        AC P0C6W0.1
#=GS A0A1B3Q5W8_9BETC/3481-3741  AC A0A1B3Q5W8.1
#=GS F2YDB1_SARS/3574-3836       AC F2YDB1.1
#=GS B8Q8S5_SARS/3574-3836       AC B8Q8S5.1
#=GS A0A0P0LKV0_CVH22/3297-3551  AC A0A0P0LKV0.1
#=GS A0A0K2RW65_9BETC/3612-3871  AC A0A0K2RW65.1
#=GS R1AB_SARS/3574-3836         AC P0C6X7.1
#=GS A0A0U1WHG1_9ALPC/3142-3395  AC A0A0U1WHG1.1
#=GS S5YAF0_9ALPC/3369-3621      AC S5YAF0.1
#=GS A0A0F6WGL5_9GAMC/3139-3409  AC A0A0F6WGL5.1
#=GS U5KNA9_9BETC/3644-3908      AC U5KNA9.1
#=GS H9BR07_9NIDO/2823-3080      AC H9BR07.1
#=GS B1PHI7_9ALPC/3530-3784      AC B1PHI7.1
#=GS H9BQZ9_9NIDO/2845-3102      AC H9BQZ9.1
#=GS R1A_CVMJH/3667-3927         AC P0C6V1.1
#=GS B8Q8S4_SARS/3574-3836       AC B8Q8S4.1
#=GS R1A_CVM2/3610-3869          AC P0C6U9.1
#=GS A0A0K1YZY7_SARS/3574-3836   AC A0A0K1YZY7.1
#=GS Q6UZF5_SARS/3574-3836       AC Q6UZF5.1
#=GS A0A0F6SKM6_9GAMC/3139-3409  AC A0A0F6SKM6.1
#=GS A0A1X9JQL5_9ALPC/3178-3437  AC A0A1X9JQL5.1
#=GS R1A_BCHK9/3437-3699         AC P0C6T6.1
#=GS R1AB_CVMJH/3667-3927        AC P0C6Y0.1
#=GS A3EXE7_BCHK5/3671-3935      AC A3EXE7.1
#=GS C0KYZ6_9BETC/3667-3926      AC C0KYZ6.1
#=GS H9BR24_9NIDO/2785-3050      AC H9BR24.1
#=GS A0A0U1UZ65_BCHK4/3633-3897  AC A0A0U1UZ65.1
#=GS A8JNZ0_9ALPC/3268-3521      AC A8JNZ0.1
#=GS R1AB_CVPPU/3205-3474        AC P0C6Y5.1
#=GS A8JNZ1_9ALPC/3268-3521      AC A8JNZ1.1
#=GS A0A240FW17_9ALPC/2889-3131  AC A0A240FW17.1
#=GS T2B9U0_MERS/3581-3845       AC T2B9U0.1
#=GS S5Z1D1_9ALPC/3369-3621      AC S5Z1D1.1
#=GS A0A125R5A4_9ALPC/3217-3486  AC A0A125R5A4.1
#=GS A0A0U1WHK4_SARS/3574-3836   AC A0A0U1WHK4.1
#=GS Q0ZJB1_CVHK1/3664-3923      AC Q0ZJB1.1
#=GS A0A0P0ILY9_CVH22/3297-3551  AC A0A0P0ILY9.1
#=GS A0A023YA54_MERS/3682-3946   AC A0A023YA54.1
#=GS Q06BE1_9BETC/3577-3836      AC Q06BE1.2
#=GS B2BW31_9GAMC/3085-3365      AC B2BW31.1
#=GS E0ZN59_BCHK9/3412-3674      AC E0ZN59.1
#=GS B7U2M9_9BETC/3577-3836      AC B7U2M9.1
#=GS R1A_BCHK5/3672-3936         AC P0C6T5.1
#=GS R1A_SARS/3574-3836          AC P0C6U8.1
#=GS A0A0K1Z0N1_SARS/3574-3836   AC A0A0K1Z0N1.1
#=GS A0A0U1WHD1_9ALPC/3430-3684  AC A0A0U1WHD1.1
#=GS R1AB_SARS2/3597-3859        AC P0DTD1.1
#=GS B1PHI6_9ALPC/3530-3784      AC B1PHI6.1
#=GS A0A0U1WHG0_SARS/3569-3831   AC A0A0U1WHG0.1
#=GS H9BR16_9NIDO/2814-3070      AC H9BR16.1
#=GS A3EXC0_BCHK4/3635-3899      AC A3EXC0.1
#=GS R1A_BC512/3339-3590         AC P0C6F6.1
#=GS B1PHK0_9ALPC/3437-3691      AC B1PHK0.1
#=GS B8Q8U6_SARS/3574-3836       AC B8Q8U6.1
#=GS R1A_CVHOC/3577-3836         AC P0C6U7.1
#=GS R1AB_CVMA5/3663-3921        AC P0C6X9.1
#=GS R1AB_FIPV/3230-3499         AC Q98VG9.2
#=GS H9AA60_9BETC/3598-3857      AC H9AA60.1
#=GS F2YDB2_SARS/3574-3836       AC F2YDB2.1
#=GS Q9J3E9_9BETC/3661-3920      AC Q9J3E9.1
#=GS R1AB_BCHK5/3672-3936        AC P0C6W4.1
#=GS R1A_BC279/3580-3842         AC P0C6F5.1
#=GS H9BR34_9NIDO/2738-2995      AC H9BR34.1
#=GS B8Q8U7_SARS/3574-3836       AC B8Q8U7.1
#=GS A0A140ESF0_9NIDO/2835-3092  AC A0A140ESF0.1
#=GS R1AB_CVH22/3292-3546        AC P0C6X1.1
#=GS R1AB_CVM2/3610-3869         AC P0C6X8.1
#=GS T2B9I2_MERS/3581-3845       AC T2B9I2.1
#=GS R1AB_BCHK4/3625-3889        AC P0C6W3.1
#=GS A0A125R5A3_9ALPC/3217-3486  AC A0A125R5A3.1
#=GS A0A059VJE6_9ALPC/3324-3579  AC A0A059VJE6.1
#=GS U5LR11_9BETC/3644-3908      AC U5LR11.1
#=GS B1PHK1_9ALPC/3437-3691      AC B1PHK1.1
#=GS R1AB_BC279/3580-3842        AC P0C6V9.1
#=GS R1A_BCHK4/3625-3889         AC P0C6T4.1
#=GS B2BW32_9GAMC/3085-3365      AC B2BW32.1
#=GS R1AB_BCHK9/3437-3699        AC P0C6W5.1
#=GS B1PHJ4_9ALPC/3474-3728      AC B1PHJ4.1
#=GS A0A088DIE1_9BETC/3738-4003  AC A0A088DIE1.1
#=GS A0A0U1UZC3_9ALPC/3197-3450  AC A0A0U1UZC3.1
#=GS A3EXA2_BCHK4/3625-3889      AC A3EXA2.1
#=GS A0A0K1RLM9_9ALPC/3201-3470  AC A0A0K1RLM9.1
#=GS D9J203_9ALPC/3193-3463      AC D9J203.1
#=GS A0A0U1UZ20_9ALPC/3437-3691  AC A0A0U1UZ20.1
#=GS D9J202_9ALPC/3193-3463      AC D9J202.1
#=GS A0A0A7UXR0_9BETC/3624-3883  AC A0A0A7UXR0.1
#=GS A3EXI9_BCHK9/3432-3694      AC A3EXI9.1
#=GS R1A_CVH22/3292-3546         AC P0C6U2.1
#=GS H9BZX6_9BETC/3665-3924      AC H9BZX6.1
#=GS B1PHJ3_9ALPC/3474-3728      AC B1PHJ3.1
#=GS R1A_CVPPU/3205-3474         AC P0C6V2.1
#=GS V5TFR4_9GAMC/3085-3365      AC V5TFR4.1
#=GS H9TEX0_9ALPC/3206-3475      AC H9TEX0.1
#=GS Q0PL14_9ALPC/3202-3471      AC Q0PL14.1
#=GS R9QTB2_SARS/3566-3828       AC R9QTB2.1
#=GS A0A0U1UZA8_9ALPC/3473-3727  AC A0A0U1UZA8.1
#=GS B6VDX7_THCOV/2814-3071      AC B6VDX7.1
#=GS A0A0K2RVJ3_9BETC/3612-3871  AC A0A0K2RVJ3.1
#=GS H9TEW9_9ALPC/3206-3475      AC H9TEW9.1
R1A_SARS2/3597-3859                    ..s-TQWSLFFFLYENAFLPFAMGIIAMSAFAMMF.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLDM.....VDTSLSGFKLKDCVMYASAVVLLILM.......TARTVYDD..GARRVWTLMNVLTLV...YKVY.........YGNAL.DQ---AISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYC..FLGYFCTCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQ
A0A0U1WHG4_9ALPC/3283-3537             ...LLHYTAFFWISPGFITPMFFMLLMVSVFFMCA.LKHKIMFLYTFLIPAVIVTSCYNFA...WDW..YITSVLATTFD.Y---.....-HVSLLSLDIQGVINVSACVFVTLLH.......TFRFCKSSvnYSSVITYCCSLLFVA...YGFY.........-----.-MGSDALSLVMMVLFNFTSNWYVGAIVYKIAFYTRD-MT----LLPMLVGNVKAVMLCYI..VLGYFCCVYYGILYWINRF....FKLTLGVYDFKVSANEFKYMVANGLHAPRGVFDAVALSVKLIGIGGEKTIKVSTVQ
A0A096XNJ3_9ALPC/3282-3541             ...FLMYTSVSILQWEVIISVLVGLTCASAITIVF.IKHKMVFLYGYVVPATLVVVFSNFL...WDY..VVSAIIMEHAS.F---.....-MSAYFSFDVQSVFNIFMLSFVLILH.......LARFYCSG..-GALITCLFSCAYTVg.lFMYF.........-----.-VKIDVLSAFFMFISGIQCSWAITWSSYKIAVYAMS---YVSPYYIEVFGYTKVLMVLYL..CMGYLFCVYYGILYWVNRFtmnnFSMCLGYYDYCVSQAEFKYMVANNLKCPTNPMEALYLNIKLMGVGGPKIIKLSTIQ
E0XIZ2_9BETC/3565-3827                 ..s-TQWSLFFFVYEHAFLPFTMGVVCFAACAMVL.VKHKHAFLCLFLLPSLITVAYFN--...MIY..MPASWVMRVMT.WLDL.....VDTSLSGYRLKDCVMYALAAFLLILM.......TARTVYDD..AARRVWTVMNVITLV...YKVY.........YGNSL.DQ---ALAMWALVISVTSNYSGVVTTIMFLARAIVFLCVEYYPILFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYFVSTQEFRYMNSQGLLPPKTSLDAFKLNVKLLGIGGKPCIKVATVQ
R1AB_CVHOC/3577-3836                   ...FVKWTMFMYVTTNM-FSITFCALCVISLAMLL.VKHKHLYLTMYITPVLFTLLYNNYL...VVY..-KHTFRGYVYA.WLSYy...vPSVEYTYTDEVIYGMLLLVGMVFV--.......TLRSINHD..LFSFIMFVGRLISVF...SLWY.........KGSNL.-----EEEILLMLASLFGTYTWTTVLSMAVAKVIAKWVA-VNVLYFTDIPQIKIVLLCYL..FIGYIISCYWGLFSLMNSL....FRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ
R1AB_IBVB/3110-3379                    lca---IVLFTAVPLKFYVYAAVILLMAVLFISFT.VKHVMAYMDTFLLPTLITVIIGVCA..eVPF..IYNTLISQVVI.FLSQ....wYDPVVFDTMVPWMFLPLVLYTAFK--.......CVQGCYMN.sFNTSLLMLYQFV-KL..gFVIYtss..ntltAYTEG.NWELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLY---YCNA---TYLNNYVLMAVMVN..CIGWLCTCYFGLYWWVNKV....FGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQ
A0A0U2UMS4_9ALPC/3203-3472             ...FFMYTPFTWINPTFVSIVLVVTTLISTVLVSG.IKHKMLFFMSFVLPSVILVTANNLC...WDL..SYYEGLQSIVE.N---.....TNIMFLPVDMQGVMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVTTIFVI...FNMVkvfg.tsdePWNEN.QISFCFVNMLTMIVSLTTKDWMVVVASYRVAYYIVV--CVMPPAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWINRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQ
K4K1U5_9ALPC/3324-3575                 ...LLQYTAFFWVSPGFVTPVFFALLLVSFILMCF.LKHKVLFLYTFLIPSVIIMASYNFV...WDW..SVAAELARIFD.Y---.....-HVSIVSFDIQGLLNVAVCLFVTLLH.......TMRFFKTN..-TSISTYILSLAFTV...YGFV.........-----.-VGSDVLSIVMTLLFNLTSSWYVGAIVYKLAYYLQY---Y--TSFAQILGSIKAIMLCYI..GLGYLCCVYYGFLYWINRF....CKLSLGVYDFKVSANEFKFMVANGLQAPRGVFDSLALSIKLMGIGGEKTIKVSSVQ
R1A_CVMA5/3663-3921                    ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.IKHKHLYLTMYIMPVLC-TFYTNYL...VV-..YKQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSIMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDVPQIKLVLLSYL..CIGYVCCCYWGILSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
E0ZN51_BCHK9/3432-3694                 ..l-AQWTFVGALPLSLLLPLIGFLACCVGAVSLL.VKHKHAYLTVYLLPVAMVTAYYNFQ...YTP.eGVQGYLLSVYN.YVNP.....GRIDVVGTDIVTMLIISVACTL-L--.......SMRMVRTD..AYSRVWYVCTAIGWL...YNCW.........---TG.SPDTVAISYLTFMVSVFTNYTGVACVSLYAAQLMTWVLIYLDPAIVLLYGKFRCVLVCYL..IVGYFCTCYFGVFNLINRL....FRCTLGNYEYVVSSQELRYMNSHGLLPPTTSWQALMLNMKLAGIGGIPIYKVSTIQ
R1A_IBVB/3110-3379                     lca---IVLFTAVPLKFYVYAAVILLMAVLFISFT.VKHVMAYMDTFLLPTLITVIIGVCA..eVPF..IYNTLISQVVI.FLSQ....wYDPVVFDTMVPWMFLPLVLYTAFK--.......CVQGCYMN.sFNTSLLMLYQFV-KL..gFVIYtss..ntltAYTEG.NWELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLY---YCNA---TYLNNYVLMAVMVN..CIGWLCTCYFGLYWWVNKV....FGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQ
H9BZX5_9BETC/3665-3924                 ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.IKHKHLYLTMYIMPVLCTLFYTNYL...VVY..-KQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLFAMVFV--.......TMRSINHD..VFSIMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLRTAKVIAKWLA-VNVLYFTDVPQIKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
R1AB_BC512/3339-3590                   ..m-LNHSKLFWINPGYITPVFLAIIVASSALMLL.VKHKLLFLQLYLLPSLCIVSGYNIF...KDY..HFYTYMLEEFD.Y---.....-KVPFGGFNVTGVLNISLCCFVMGLH.......TFRFLQTP..-NKIFSYVVAVLTVL...YTYY.........-----.-YSTDVLGLILTSMSGFTNYWFIGTATYKLATYVLP-----HTSLLDSFDAIKAVVFLYL..LLGYCNCVYYGSLYWINRF....CKLTLGCYEFKVSAAEFKYMVANGLRAPTGVFDALILSLKLIGVGGRKTIKISSVQ
A0A1B3Q5W8_9BETC/3481-3741             ..l-SQWTVLGALPLQLLLPLLGFISCCVGFMAMF.IKHKHTFLTVYLLPVVMVAAYYNFQ...YQP.eGIQGYLLYVYN.YVNP.....GRFD-MGFDLTTM-LVISGITTLL--.......SVRIAKSD..TYSRVWYVCTAIGWV...YNCC.........TGT--.-AETIALSYLTFVVSVFTNYTGVACISVYVSQVIVWAMAWVEPG-ILMYGHFRCVLVCYV..IIGYCCTCYFGVFNLLNRL....FRCTLGTYDYVVSSQELRYMNSNGLSPPTNSWQAMVLNLKLAGIGGVPMYKVATIQ
F2YDB1_SARS/3574-3836                  ..s-TQWSLFSFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
B8Q8S5_SARS/3574-3836                  ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
A0A0P0LKV0_CVH22/3297-3551             ...LFVYTNTIWVNPGFLTPFMLLFVIVSLCLTSV.VKHKMLFLQVFLLPSIIVAAVQNCA...WDY..HVTKVLAEKFD.Y---.....-NVSIMQMDIQGFVNIFICLFVALLH.......TWRFARER..CTHWCTYLFSLVAVL...YTAF.........-----.-YSYDYVSLLVMFLCAISNEWYIGAIIFRLCRICVA---FMPVEYVSYFGGVKTVLLFYM..VLGFCSCVYYGLLYWVNRF....CKCTLGVYDFTVSPAEFKYMIANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQ
A0A0K2RW65_9BETC/3612-3871             ...FVKWTMFMYVTTNM-LSITFCALCVISLAMLL.VKHKHLYLTMYIIPVLFTLLYNNYL...VVY..-KQTFRGYVYA.WLSYy...vPSVEYTYTDEVIYGVLLLIGMVFV--.......TLRSINHD..LFSFIMFGGRVISVV...SLWY.........MGSNL.EEE-----ILLMLASLFGTYTWTTALSMAAAKVIAKWVA-VNVLYFTDIPQIKIVLICYL..FIGYIISCYWGLFSLMNSL....FRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ
R1AB_SARS/3574-3836                    ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
A0A0U1WHG1_9ALPC/3142-3395             ...FLSYSALFWINANVLTPIFLCLCGFSVVLTVG.LKHKLLFLYTFLIPTVVLLAAINLS...WDF..YLRALLSSTVG.Y---.....-HTSLMSFDLQGVLNIAICAFVSGLH.......LYRFSPNV..-GSCATLLMSLGVTV...YNYW.........-----.-FDTDYFSIIMTLLLNMSSTWYIGAIAYKIASVMIV---FVPAPLIAAFGPIKTVLMVYV..CIGYVFCMYWGFCYWLNRV....SKLTLGVYDFKVSSAEFKYMVANGLSAPRSVLDTLYLSFRLLGVGGERTIKVATVQ
S5YAF0_9ALPC/3369-3621                 ..l-VIYTPFFWVSPAYITPLFLIVSGVSILCMSL.LKHKTLFLQMFLIPAVIAVSAYNLA...YDL..EIRTWMATKLD.Y---.....-HASILSFNIQGIFNIMVCCVVVCLH.......AYRCVTRS..-SSVFTMVVACVTSC...YSYV.........-----.-ICGDALSAAMAIMLNITGNWFVGAGAYRLATYIVL----LNPALPALVGDVKAIVFVYV..AVGYVCCVFYGILYWVNRF....CKLSLGVYDFMVSPAEFKYMVANGLRAPTGAFDSLFLSARLLGIGGQRTIKISTVQ
A0A0F6WGL5_9GAMC/3139-3409             lcs---IVLFTAIPYRYYLHGAVVLFATVLFVSFT.VKHVMAYMDTFLLPTLITVIIGVCA..eVPF..IYNTLISQIVI.FFSQ....wYDPVVFDTVVPWMFLPLVLYTAF--K.......CIQGCYSV.nSFNTSLLVLYQFMKL..gFVIYtss...ntlTAYSEgNWELFFELVHTTVLANVSSNSLIGLIVFKFAKWMLY---YCNAS---YLNNYVLMAVIIN..GIGWMFTCYFGFYWWINKV....FGLTLGKYSFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQ
U5KNA9_9BETC/3644-3908                 ...LTKFTIWNFLFNVIPLQLTPIMFVVLALAMLC.VKHKHAFLTTFLLPGALCLTYANLV...YEPntPVSSFLIMCVN.WLNPd...gTYMRTTHMDLGVYVSLCLALLVV---.......VRRLYKPS..VTNCAFALTSLV---...-MWF.........YSYSI.GDASSPIVYLQFVTAATSDYMVTVFLAVNVAKCLTYLTSMYFTTLSVVVPEVKIVLLMYI..CIGFICTMYFGVFSFLNLK....MRAPMGVYSYEVSTQEFRYMNANGLRAPRNSWDAMVLNFKLLGVGGVPCIKIASVQ
H9BR07_9NIDO/2823-3080                 ail---LATLHVFPTTLYPVVLPMAAAIAVFLVIT.IKHTVVFTTTFLLPALIMMVVSANT...FW-..IPNTYLRSFYQ.YVFGs...sISQQLYGYSVAFYLCVYIALAINY--.......TLRAVRYR..ATSISTFAIQCMQFG...YLAH.........VMYRL.CTTTWTEDLVFTAVSMLTSHPMLAGVCWWLAGRVPLPLL---------IPDVAVRVLLYV..VGGYVICMRFGLMWIINRF....TALPMGTYSYMVSIEQLKYMMAVKMSPPRNAFEVLLANLRLLGLGGVRNIAISTVQ
B1PHI7_9ALPC/3530-3784                 ...LLYYTSSYWIKPDLITAVFVLLFGVAVMLTFT.IKHKVLFLYTFLIPSVVISACYNLA...WDL..YIRELLAKYFD.Y---.....-HMSIFSMDIQGCFNILACIFVNAIH.......TWRFVKTG..TATRLTYVLSLCVSV...YNYW.........-----.-CCGDFLSLAMMVLLNINNNWYIGAFAYRFSVFVVN---YMDPSVIRMLGGVKVILFMYV..LCGYLCCVYYGICYWFNRF....FKCTMGLYEFKVSPAEFKYMVANDLRAPTGVFDSMSLSLKLMGLGGERTIKISTVQ
H9BQZ9_9NIDO/2845-3102                 ..t-MLLAAMHVFPVHLYPIVLPGFTIVAFLLTLT.IKHTVVFTTTYLLPSLLMMVVNANT...FW-..IPNTFLRTCYE.TIFGs...pIAQRLYGYTVALYMLIYAGLAINY--.......TLKTLRYR..ATSFSTFCMQWLQYG...YVAH.........IVYKL.LTKPWTESLLFTAFSMLTIHPLLAALSWWLAGRVALPII---------MPDLAIRVLAYN..VIGYVMCVRFGLIWLANRF....TTIPMGTYQYMVSVEQLKYMMAVKMSPPRNAFEVLIANIRLLGLGGNRNIAVSTVQ
R1A_CVMJH/3667-3927                    ...FVKWTMFMYVTTHM-LGVTLCALCFVIFAMLL.IKHKHLYLTMYIMPVLCTLFYTNYL...VVG..YKQSFRGLAYA.WLSYf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSTMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDIPQIKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
B8Q8S4_SARS/3574-3836                  ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
R1A_CVM2/3610-3869                     ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.VKHKHLYLTMFIMPVLCTLFYTNYL...VVY..-KQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSVMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDVPQVKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALVLNFKLLGIGGVPVIEVSQIQ
A0A0K1YZY7_SARS/3574-3836              ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFRLNIKLLGIGGKPCIKVATVQ
Q6UZF5_SARS/3574-3836                  ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
A0A0F6SKM6_9GAMC/3139-3409             lcs---IVLFTAIPYRYYLHGAVVLFATVLFVSFT.VKHVMAYMDTFLLPTLITVIIGVCA..eVPF..IYNTLISQIVI.FFSQ....wYDPVVFDTVVPWMFLPLVLYTAF--K.......CIQGCYSV.nSFNTSLLVLYQFMKL..gFVIYtss...ntlTAYSEgNWELFFELVHTTVLANVSSNSLIGLIVFKFAKWMLY---YCNAS---YLNNYVLMAVIIN..GIGWMFTCYFGFYWWINKV....FGLTLGKYSFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQ
A0A1X9JQL5_9ALPC/3178-3437             ...FLMYTSISILHWEVVIAVLAALTCFSAMLIVF.IKHKMVFLYGYVIPATLVIVFSNFL...WDY..VVSAIVTEHAA.F---.....-MAAYFAFDVQSVFNLFMLCFVLVLH.......LARFYCSG..-GALLACLFSCAYTVg.lFVYF.........-----.-VKIDVLSAFFMFISGMQCSWALTWSSYKIATYLMS---YVSAYYIEVFGYTKILMVIYL..GVGYLFCAYYGILYWVNRFtmsnFSLCLGYYDYCVSQAEFKYMVANNLKCPTNPLEALYLNIKLMGVGGPKKIKLSTIQ
R1A_BCHK9/3437-3699                    ..l-AQWTFVGALPFTLLLPLIGFVAVCVGFVSLL.IKHKHTYLTVYLLPVAMVTAYYNFQ...YTP.eGVQGYLLSLYN.YVNP.....GRIDVIGTDLLTMLIISVACT-LL--.......SVRMVRTD..AYSRIWYVCTAVGWL...YNCW.........---TG.SADTVAISYLTFMVSVFTNYTGVACASLYAAQFMVWVLKFLDPTILLLYGRFRCVLVCYL..LVGYLCTCYFGVFNLINRL....FRCTLGNYEYVVSSQELRYMNSHGLLPPTNSWQALMLNIKLAGIGGIPIYRVSTIQ
R1AB_CVMJH/3667-3927                   ...FVKWTMFMYVTTHM-LGVTLCALCFVIFAMLL.IKHKHLYLTMYIMPVLCTLFYTNYL...VVG..YKQSFRGLAYA.WLSYf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSTMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDIPQIKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
A3EXE7_BCHK5/3671-3935                 ...LTKFTIWNYLFEAIPLQLTPVILCVMACVMLM.VKHRHTFLTLFLLPTAICLTYANIV...YEPqtPVSSALIAVAN.WLNPa...sVYMRTTHTDLGVYLSLCFALAVV---.......VRRLYRPN..ASNLALALGSAMVWF...YTYT.........----T.GDCSSPLTYLMFLTTLTSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYL..AVGYFCTVYFGVFSLLNLK....LRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNIKLIGIGGTPCIKIASVQ
C0KYZ6_9BETC/3667-3926                 ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.IKHKHLYLTMYIMPVLCTLFYTNYL...VVY..-KQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSTMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDIPQIKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
H9BR24_9NIDO/2785-3050                 ...LFYFVILWCVTPQYYTTVTFCVSIILAICTMTlVKHTTVFLLGFICPLVVVTARYSYI...LF-..IPNSVVRRVFF.YLFE.....----DLFVNLSFFYIVAAVVFVVWLQ.......CIRGLYECmhKRYYITTVLDFIYRAv.wAFYVg......yeLSQAC.VTNTVDVGHVFHLSLLLSPSPITSHIAFGLSYYIVQPLDD-----SYIVPIYVVRLFVFY..CIGLIITMRYGVFWFINKL....TGIPVGTYKFMVSRDELKYMMATRMKPPTNAIEVIWTNFKLLGVGGKREIVVSTVQ
A0A0U1UZ65_BCHK4/3633-3897             ...LTKFTMWTYLFETIPTQMTPLLLGFMACVMFT.VKHKHTFLSLFLLPVALCLTYANIV...YEPqtLVSSTLIAVAN.WLTPt...sVYMRTTHLDFGLYISL---SFVLAII.......VRRLYRPS..MSNLALALCSGVMWF...YTYV.........----I.GDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGMVFLYAPHLGFILPEVKLVLLIYL..GLGYMCTMYFGVFSLLNLK....LRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQ
A8JNZ0_9ALPC/3268-3521                 ...FFMYSTILWINPGLITTFLGLFVMLSMLLASC.IKHKMLFLQLFLLPSIIIAACYNFA...WDM..EVTRMLATQFD.Y---.....-HVSFLNMDIQGAINIIVCFIGISLH.......TYRFLDTQ..LRSYSTYVLSMCTVL...YTFY.........-----.-YGYDSLSLAIMLLGFGCREWYVGTAAFRLAQFIVP----YCPGLISFVGDIKAVLVLYL..VFGFVATVYFGLLYWLNRV....LKLTLGCYDFKVSAAEFKYMVANGYTAPRGPFDSVLLSLRLLGVGGQKTIKVSTVQ
R1AB_CVPPU/3205-3474                   ...FFMYTPFTWINPTFVSIVLAVTTLISTVFVSG.IKHKMLFFMSFVLPSVILVTAHNLF...WDF.sYYESLQSIVEN.T---.....-NTMFLPVDMQGVMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVTTILVI...FNMVkifg.tsdePWTEN.QIAFCFVNMLTMIVSLTTKDWMVVIASYRIAYYIVV--CVMPSAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQ
A8JNZ1_9ALPC/3268-3521                 ...FFMYSTILWINPGLITTFLGLFVMLSMLLASC.IKHKMLFLQLFLLPSIIIAACYNFA...WDM..EVTRMLATQFD.Y---.....-HVSFLNMDIQGAINIIVCFIGISLH.......TYRFLDTQ..LRSYSTYVLSMCTVL...YTFY.........-----.-YGYDSLSLAIMLLGFGCREWYVGTAAFRLAQFIVP----YCPGLISFVGDIKAVLVLYL..VFGFVATVYFGLLYWLNRV....LKLTLGCYDFKVSAAEFKYMVANGYTAPRGPFDSVLLSLRLLGVGGQKTIKVSTVQ
A0A240FW17_9ALPC/2889-3131             ...WLMMSAIYYFSKDLFMLLIPVGVLISFVLSLL.VKHKIMFINLYLLPTLIVMMVDNFS...LYM..YVANFMS----.----.....-DFNMSGFNLNFIVSLVSVVAVFFLH.......LYRFINAK..-KDWFNIMVALVGSL...WFYM.........-----.--TYNETALLTTVLISVNPDWYIGLVTYHGVKIAFKLMGA--------TFTYKYLALCYV..SAGFVITMRFGVLYWINKF....TGFTFGKYDYKVSAREFKYIVANGLKTPTGVFETLKLNYNLIGIGGNKNIKVSTVQ
T2B9U0_MERS/3581-3845                  ..a-TKFTLWNYLFETIPTQLFPLLFVTMAFVMLL.VKHKHTFLTLFLLPVAICLTYANIV...YEPttPISSALIAVAN.WLAPt...nAYMRTTHTDIGVY-ISMSLVLVIV--.......VKRLYNPS..LSNFALALCSGVMWL...YTYS.........----I.GEASSPIAYLVFVTTLTSDYTITVFVTVNLAKVCTYAIFAYLPQLTLVFPEVKMILLLYT..CLGFMCTCYFGVFSLLNLK....LRAPMGVYDFKVSTQEFRFMTANNLTAPRNSWEAMALNFKLIGIGGTPCIKVAAMQ
S5Z1D1_9ALPC/3369-3621                 ..l-VIYTPFFWVSPAYITPLFLIVSGVSILCMSL.LKHKTLFLQMFLIPAVIAVSAYNLA...YDL..EIRTWMATKLD.Y---.....-HASILSFNIQGIFNIMVCCVVVCLH.......AYRCVTRS..-SSVFTMVVACVTSC...YSYV.........-----.-ICGDALSAAMAIMLNITGNWFVGAGAYRLATYIVL----LNPALPALVGDVKAIVFVYV..AVGYVCCVFYGILYWVNRF....CKLSLGVYDFMVSPAEFKYMVANGLRAPTGAFDSLFLSARLLGIGGQRTIKISTVQ
A0A125R5A4_9ALPC/3217-3486             ...FFMYTPFTWINPAFVSVILAITTLVSVILVVG.IKHKMLFFMSFVMPSVILATAHNVV...WDM.tYYESLQVIVEN.V---.....-NTTFLPVDMQGVMLALFCVIVFVTY.......TVRFFTCK..-QSWFSLFVTTGFVV...FNIVkllg.migePWTDD.HILLCLVNMLTMLISLTTKDWFVVFVSYKLAYYIVV--YVMHPAFVQDFGFIKCVSVIYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSPAELKYMTANNLSAPKTAYDAMILSVKLMGIGGERNIKISTVQ
A0A0U1WHK4_SARS/3574-3836              ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
Q0ZJB1_CVHK1/3664-3923                 ...FVKWTIFMYINTHM-IGVTLCVLCFVSFMMLL.VKHKHFYLTMYIIPVLCTLFYVNYL...VVY..-KEGFRGLTYV.WLSYf...vPAVNFTYVYEVFYGCILCVFAIFI--.......TMHSINHD..IFSLMFLVGRIVTLI...SMWY.........FGSNL.EED-----VLLFITAFLGTYTWTTILSLAIAKIVANWLS-VNIFYFTDVPYIKLILLSYL..FIGYILSCYWGFFSLLNSV....FRMPMGVYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQ
A0A0P0ILY9_CVH22/3297-3551             ...LFVYTNTIWVNPGFLTPFMLLFVIVSLCLTSV.VKHKMLFLQVFLLPSIIVAAVQNCA...WDY..HVTKVLAEKFD.Y---.....-NVSIMQMDIQGFVNIFICLFVALLH.......TWRFARER..CTHWCTYLFSLVAVL...YTAF.........-----.-YSYDYVSLLVMFLCAISNEWYIGAIIFRLCRICVA---FMPVEYVSYFGGVKTVLLFYM..VLGFCSCVYYGLLYWVNRF....CKCTLGVYDFTVSPAEFKYMIANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQ
A0A023YA54_MERS/3682-3946              ..c-TKFTLWNYLFQTIPTQLTPLMIIVAACVMLL.VKHKHTFLTLFLLPTALCLTYANIV...YEPstPVSSALIAVAN.WLAPn...nMYMRTTHTDLGLYLSLSLALAVVV--.......-KRLYTPS..LSNLALALCSLVMWV...YTY-.........---SI.GEHSSPVAYLVFVTTLTSDYTVTVFTAVNFAKFLTYLIYSYSPQTMLVFPEVKMILLMYT..FIGYVCTCYFGVFSLLNFK....LRSPMGVYDFKVSTQEFRYMTANGLHAPRNSWEAMALNFKLIGIGGTPCIKVASVQ
Q06BE1_9BETC/3577-3836                 ...FVKWTMFMYVITNM-LSITFCALCVISLAMLL.VKHKHLYLTMYIIPVLFTLLYNNYL...VVY..-KQTFRGYVYA.WLSYy...vPSVEYTYTDEVIYGMLLLIGMVFV--.......TLRSINHD..LFSFIMFVGRVISVV...SLWY.........MGSNL.EEE-----ILLMLASLFGTYTWTTALSMAAAKVIAKWVA-VNVLYFTDIPQIKIVLVCYL..FIGYIISCYWGLFSLMNSL....FRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ
B2BW31_9GAMC/3085-3365                 ..l-TVYASCNVVPLDMLPQLIMSVGVGFAIMFVT.LKHQHFFMTTAIIPYVVTSILGMALekpVFYngWYFSFFHDFLK.YVGIeathqYAWMLLPFALYVAYNVAKGVGSTLINfnaggisLWNSLVYG..--------MRWGSTLrflY--Talm..sdnvFETFG.SSGEFYINMHMACVGLFSSDPASGYIIMWIVKQVNY-VG-----YLAYFTELSYYTFVFYscVLCYMFSCYFGLFWFTNKV....LGTTFGKYPYKVSAGQFKYMMLNGMRGPRSTADVLITNMRLAGIGGERTITVSTVQ
E0ZN59_BCHK9/3412-3674                 ..l-AQWTFVGALPLTLLLPLIGFVALCVSFVSLL.IKHKHTYLTVYLLPVAMVTAYYNFQ...YTP.eGVQGYLLSLYN.YVNP.....GRVDIIGTDIVTMVIISVTCTLL---.......SVRIVKTD..AYSRVWYVCTAIGWL...YNCW.........---TG.SADTVAISYLTFMVSVFTNYTGVACTSLYVAQFMVWVVGYLDPSLLLLYGKFRCVLVCYL..VVGYFCTCYFGVFNLINKL....FRCTLGNYEYVVSSQELRYMNSHGLLPPTTSWQALMLNVKLAGIGGIPIYKVSTVQ
B7U2M9_9BETC/3577-3836                 ...FVKWTMFMYVTTNM-LSITFCALCVISLAMLL.VKHKHLYLTMYIIPVLFTLLYNNYL...VVY..-KQTFRGYVYA.WLSYy...vPSVEYTYTDEVIYGMLLLIGMVFV--.......TLRSINHD..LFSFIMFVGRVISVV...SLWY.........MGSNL.EEE-----ILLMLASLFGTYTWTTALSMAAAKVIAKWVA-VNVLYFTDIPQIKIVLVCYL..FIGYIISCYWGLFSLMNSL....FRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ
R1A_BCHK5/3672-3936                    ...LTKFTIWNYLFEVIPLQLTPLVLCVMACVMLT.VKHKHTFLTLFLLPTAICLTYANIV...YEPqtPVSSALIAVAN.WLNPa...sVYMRTTHTDLGVYLSLCFALAVV---.......VRRLYRPN..ASNLALALGSAMVWF...YTYT.........----T.GDCSSPLTYLMFLTTLTSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYL..AVGYFCTVYFGVFSLLNLK....LRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNMKLIGIGGTPCIKIASVQ
R1A_SARS/3574-3836                     ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
A0A0K1Z0N1_SARS/3574-3836              ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFRLNIKLLGIGGKPCIKVATVQ
A0A0U1WHD1_9ALPC/3430-3684             ...MLYYTSSYWIKPDLITPIFLVFFAIALFLTAF.IKHKVLFLYTFLVPGIVITATTNLA...WDC..YVRDLLAKYLD.Y---.....-HMSLFNMDIQGFFNIAACFIVNALH.......TWRYMRSG..CTTRITYVVSLVVSI...YNYW.........-----.-YVGDVLSLAMMLLLNINSNWYIGAFAYRFVLIVAR---YMNPTVVAIIGPFKLVMALYV..AVGYLCCVYYGILYWLNRF....FKFTLGIYDFKVSAAEFKYMVANDLRAPGGVFDSLLLSFRLMGIGGEKTIKISTVQ
R1AB_SARS2/3597-3859                   ..s-TQWSLFFFLYENAFLPFAMGIIAMSAFAMMF.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLDM.....VDTSLSGFKLKDCVMYASAVVLLILM.......TARTVYDD..GARRVWTLMNVLTLV...YKVY.........YGNAL.DQ---AISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYC..FLGYFCTCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQ
B1PHI6_9ALPC/3530-3784                 ...LLYYTSSYWIKPDLITAVFVLLFGVAVMLTFT.IKHKVLFLYTFLIPSVVISACYNLA...WDL..YIRELLAKYFD.Y---.....-HMSIFSMDIQGCFNILACIFVNAIH.......TWRFVKTG..TATRLTYVLSLCVSV...YNYW.........-----.-CCGDFLSLAMMVLLNINNNWYIGAFAYRFSVFVVN---YMDPSVIRMLGGVKVILFMYV..LCGYLCCVYYGICYWFNRF....FKCTMGLYEFKVSPAEFKYMVANDLRAPTGVFDSMSLSLKLMGLGGERTIKISTVQ
A0A0U1WHG0_SARS/3569-3831              ..s-TQWSLFFFVYENAFLPFTLGIMVIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASTLVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNSL.EQA---ISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
H9BR16_9NIDO/2814-3070                 ..v-YMTALMYVIPNNVLYIVVPATLMTAIVTQLF.IKHTTVYMLAYCLPMVVLCVYNTFT...IW-..VPNTMFRQIVY.YAYTc...fYEPSIAQYMVYLSVFLVSINAVKSLI.......VVRSNMQA..LYALYNFVRSALFGY...TATM.........LLDSG.LV--NATYIVWFVASMSPTGSLLATLNWYLADYIASSFQF----------DLLCKMFIYH..TLGFVVCMRFGLYWWINKF....TGIPVGTYKFVVSSEQLKYMMATRMSPPKNFVEVLMTNMKLLGVGGKRDIAISTVQ
A3EXC0_BCHK4/3635-3899                 ..l-TKFIMWTYLFETIPTQMTPLLLGFMACVMFT.VKHKHTFMSLFLLPVALCLTYANIV...YEPqtLISSTLIAVAN.WLTPt...sVYMRTTHLDFGLYISL---SFVLAII.......VRRLYRPS..MSNLALALCSGVMWF...YTYV.........----I.GDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGLVFFYAPHLGFILPEVKLVLLIYL..GLGYMCTMYFGVFSLLNLK....LRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQ
R1A_BC512/3339-3590                    ..m-LNHSKLFWINPGYITPVFLAIIVASSALMLL.VKHKLLFLQLYLLPSLCIVSGYNIF...KDY..HFYTYMLEEFD.Y---.....-KVPFGGFNVTGVLNISLCCFVMGLH.......TFRFLQTP..-NKIFSYVVAVLTVL...YTYY.........-----.-YSTDVLGLILTSMSGFTNYWFIGTATYKLATYVLP-----HTSLLDSFDAIKAVVFLYL..LLGYCNCVYYGSLYWINRF....CKLTLGCYEFKVSAAEFKYMVANGLRAPTGVFDALILSLKLIGVGGRKTIKISSVQ
B1PHK0_9ALPC/3437-3691                 ...MLYYTSSYWIKPDLITPIFIILFAIAVFLTAF.VKHKVLFLYTFLVPGIVITATSNLA...WDC..YVRDLLAKYLD.Y---.....-HMSIFNMDIQGVFNIAACFMVNALH.......TWRYMRSG..YTTRVTYVASLIVSV...YNYW.........-----.-YVGDALSLAMMLLLNVNNNWYIGACAYRFVLIVAN---YMNPAVIGFLGSFKVIMFLYV..AVGYLCCIYYGILYWLNKF....FKCTLGVYDFKVSAAEFKYMVANDLRAPCGVFDSLLLSFRLMGIGGEKTIKISTVQ
B8Q8U6_SARS/3574-3836                  ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
R1A_CVHOC/3577-3836                    ...FVKWTMFMYVTTNM-FSITFCALCVISLAMLL.VKHKHLYLTMYITPVLFTLLYNNYL...VVY..-KHTFRGYVYA.WLSYy...vPSVEYTYTDEVIYGMLLLVGMVFV--.......TLRSINHD..LFSFIMFVGRLISVF...SLWY.........KGSNL.-----EEEILLMLASLFGTYTWTTVLSMAVAKVIAKWVA-VNVLYFTDIPQIKIVLLCYL..FIGYIISCYWGLFSLMNSL....FRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ
R1AB_CVMA5/3663-3921                   ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.IKHKHLYLTMYIMPVLC-TFYTNYL...VV-..YKQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSIMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDVPQIKLVLLSYL..CIGYVCCCYWGILSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
R1AB_FIPV/3230-3499                    ...FFMYTPFTWINPTFVSVVLAITTLVSVLLVAG.IKHKMLFFMSFVMPSVILATAHNVV...WDM.tYYESLQVLVEN.V---.....-NTTFLPVDMQGVMLALFCVVVFVIC.......TIRFFTCK..-QSWFSLFATTIFVM...FNIVkllg.migePWTDD.HFLLCLVNMLTMLISLTTKDWFVVFASYKVAYYIVV--YVMQPAFVQDFGFVKCVSIIYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSPAELKYMTANNLSAPKTAYDAMILSFKLMGIGGGRNIKISTVQ
H9AA60_9BETC/3598-3857                 ...FVKWTMFMYVTTHM-LSVTVLALCCVSFTMLL.VKHKHLYLTMYIIPVLLTLLYNNYL...VVY..-KHSFRGYVYA.WLSHf...mPSVDYTYTDEVIYSIVLLFGMIFI--.......TMRSINHD..VFSVIMFAGRVISTV...SMWY.........IGSNL.EEE-----VLLLLVSAFGTYTWTTVLSLAVSKIIAKWIS-VNLLYFTDIPLIKLVLLSYL..FVGYVVSCYWGLFSLMNKL....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPIIEVSQIQ
F2YDB2_SARS/3574-3836                  ..s-TQWSLFSFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
Q9J3E9_9BETC/3661-3920                 ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.IKHKHLYLTMYIMPVLCTLFYTNYL...VVY..-KQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSIMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDVPQIKLVLLSYL..CIGYVCCCYWGILSLLNSI....FRMPFGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
R1AB_BCHK5/3672-3936                   ...LTKFTIWNYLFEVIPLQLTPLVLCVMACVMLT.VKHKHTFLTLFLLPTAICLTYANIV...YEPqtPVSSALIAVAN.WLNPa...sVYMRTTHTDLGVYLSLCFALAVV---.......VRRLYRPN..ASNLALALGSAMVWF...YTYT.........----T.GDCSSPLTYLMFLTTLTSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYL..AVGYFCTVYFGVFSLLNLK....LRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNMKLIGIGGTPCIKIASVQ
R1A_BC279/3580-3842                    ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLVLM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNSL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
H9BR34_9NIDO/2738-2995                 ..l-FALALIHILPVNMYVMIPMIAGCTAFIVTIT.IKHTVVFLTTFLLPTLVLFVVLAPT...IW-..VPNTYLRYIYE.WIIGy...tTYDNFTSYTFCLYMLVYIIVAINF--.......TLRNVRYK..----ATSLVDFCLKSl.qYGYTl.......rIMYRL.FTETWDEHLLFPAVALLSSHPMYAAICWKLAGKFILPLV---------IPDLAVRICVYF..LLGYISCMRFGIFWFINKF....LALPIGTYKYMVSMDQLKYMMATKMSPPHNVFEVMTTNIRLFGIGGHRNIAISTVQ
B8Q8U7_SARS/3574-3836                  ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNAL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
A0A140ESF0_9NIDO/2835-3092             ..t-MLLAAMHVFPVHLYPIVLPCFTVVAFLLTLT.IKHTVVFTTTYLLPSLLMMVVNANT...FW-..IPNTFLRTCYE.TIFGs...pIAQRLYGYTVALYMLIYAGLAINY--.......TLKTLRYR..----ATSFLSFCMQWf.qYGYVa.......hIAYKL.LNKPWTESLLFTAFTMLTSHPLLAALSWWLAGRVTLPII---------MPDLAIRVLAYN..VIGYVICVRFGLMWLANRF....TTVPMGTYQYMVSVEQLKYMMAVKMSPPRNAFEVLIANIRLLGLGGNRNIAVSTVQ
R1AB_CVH22/3292-3546                   ...LFVYTTTIWVNPGFLTPFMILLVALSLCLTFV.VKHKVLFLQVFLLPSIIVAAIQNCA...WDY..HVTKVLAEKFD.Y---.....-NVSVMQMDIQGFVNIFICLFVALLH.......TWRFAKER..CTHWCTYLFSLIAVL...YTAL.........-----.-YSYDYVSLLVMLLCAISNEWYIGAIIFRICRFGVA---FLPVEYVSYFDGVKTVLLFYM..LLGFVSCMYYGLLYWINRF....CKCTLGVYDFCVSPAEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQ
R1AB_CVM2/3610-3869                    ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.VKHKHLYLTMFIMPVLCTLFYTNYL...VVY..-KQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLVAMVFV--.......TMRSINHD..VFSVMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLATAKVIAKWLA-VNVLYFTDVPQVKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALVLNFKLLGIGGVPVIEVSQIQ
T2B9I2_MERS/3581-3845                  ..a-TKFTLWNYLFETIPTQLFPLLFVTMAFVMLL.VKHKHTFLTLFLLPVAICLTYANIV...YEPttPISSALIAVAN.WLAPt...nAYMRTTHTDIGVY-ISMSLVLVIV--.......VKRLYNPS..LSNFALALCSGVMWL...YTYS.........----I.GEASSPIAYLVFVTTLTSDYTITVFVTVNLAKVCTYAIFAYLPQLTLVFPEVKMILLLYT..CLGFMCTCYFGVFSLLNLK....LRAPMGVYDFKVSTQEFRFMTANNLTAPRNSWEAMALNFKLIGIGGTPCIKVAAMQ
R1AB_BCHK4/3625-3889                   ...LTKFTMWTYLFETIPTQMTPLLLGFMACVMFT.VKHKHTFMSLFLLPVALCLTYANIV...YEPqtLISSTLIAVAN.WLTPt...sVYMRTTHFDFGLYISL---SFVLAII.......VRRLYRPS..MSNLALALCSGVMWF...YTYV.........----I.GDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGLVFFYAPHLGFILPEVKLVLLIYL..GLGYMCTMYFGVFSLLNLK....LRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQ
A0A125R5A3_9ALPC/3217-3486             ...FFMYTPFTWINPAFVSVILAITTLVSVILVVG.IKHKMLFFMSFVMPSVILATAHNVV...WDM.tYYESLQVIVEN.V---.....-NTTFLPVDMQGVMLALFCVIVFVTY.......TVRFFTCK..-QSWFSLFVTTGFVV...FNIVkllg.migePWTDD.HILLCLVNMLTMLISLTTKDWFVVFVSYKLAYYIVV--YVMHPAFVQDFGFIKCVSVIYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSPAELKYMTANNLSAPKTAYDAMILSVKLMGIGGERNIKISTVQ
A0A059VJE6_9ALPC/3324-3579             ...LVSYTKFFWVNPGYVTPMFACLSLLSSLLMFT.LKHKTLFFQVFLIPALIVTSCINLA...FDV..EVYNYLAEHFD.Y---.....-HVSLMGFNAQGLVNIFVCFVVTILHg....tyTWRFFNTP..-VSSVTYVVALLTAA...YNYF.........-----.-YASDILSCAMTLFASVTGNWFVGAVCYKAAVYMAL----RFPTFVAIFGDIKSVMFCYL..VLGYFTCCFYGILYWFNRF....FKVSVGVYDYTVSAAEFKYMVANGLRAPTGTLDSLLLSAKLIGIGGERNIKISSVQ
U5LR11_9BETC/3644-3908                 ...LTKFTIWNFLFNVIPLQLTPIMFVVLALAMLC.VKHKHAFLTTFLLPGALCLTYANLV...YEPntPVSSFLIMCVN.WLNPd...gTYMRTTHMDLGVYVSLCLALLVV---.......VRRLYKPS..VTNCAFALTSLV---...-MWF.........YSYSI.GDASSPIVYLQFVTAATSDYMVTVFLAVNVAKCLTYLTSMYFTTLSVVVPEVKIVLLMYI..CIGFICTMYFGVFSFLNLK....MRAPMGVYSYEVSTQEFRYMNANGLRAPRNSWDAMVLNFKLLGVGGVPCIKIASVQ
B1PHK1_9ALPC/3437-3691                 ...MLYYTSSYWIKPDLITPIFIILFAIAVFLTAF.VKHKVLFLYTFLVPGIVITATSNLA...WDC..YVRDLLAKYLD.Y---.....-HMSIFNMDIQGVFNIAACFMVNALH.......TWRYMRSG..YTTRVTYVASLIVSV...YNYW.........-----.-YVGDALSLAMMLLLNVNNNWYIGACAYRFVLIVAN---YMNPAVIGFLGSFKVIMFLYV..AVGYLCCIYYGILYWLNKF....FKCTLGVYDFKVSAAEFKYMVANDLRAPCGVFDSLLLSFRLMGIGGEKTIKISTVQ
R1AB_BC279/3580-3842                   ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...MVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLVLM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNSL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
R1A_BCHK4/3625-3889                    ...LTKFTMWTYLFETIPTQMTPLLLGFMACVMFT.VKHKHTFMSLFLLPVALCLTYANIV...YEPqtLISSTLIAVAN.WLTPt...sVYMRTTHFDFGLYISL---SFVLAII.......VRRLYRPS..MSNLALALCSGVMWF...YTYV.........----I.GDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGLVFFYAPHLGFILPEVKLVLLIYL..GLGYMCTMYFGVFSLLNLK....LRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQ
B2BW32_9GAMC/3085-3365                 ..l-TVYASCNVVPLDMLPQLIMSVGVGFAIMFVT.LKHQHFFMTTAIIPYVVTSILGMALekpVFYngWYFSFFHDFLK.YVGIeathqYAWMLLPFALYVAYNVAKGVGSTLINfnaggisLWNSLVYG..--------MRWGSTLrflY--Talm..sdnvFETFG.SSGEFYINMHMACVGLFSSDPASGYIIMWIVKQVNY-VG-----YLAYFTELSYYTFVFYscVLCYMFSCYFGLFWFTNKV....LGTTFGKYPYKVSAGQFKYMMLNGMRGPRSTADVLITNMRLAGIGGERTITVSTVQ
R1AB_BCHK9/3437-3699                   ..l-AQWTFVGALPFTLLLPLIGFVAVCVGFVSLL.IKHKHTYLTVYLLPVAMVTAYYNFQ...YTP.eGVQGYLLSLYN.YVNP.....GRIDVIGTDLLTMLIISVACT-LL--.......SVRMVRTD..AYSRIWYVCTAVGWL...YNCW.........---TG.SADTVAISYLTFMVSVFTNYTGVACASLYAAQFMVWVLKFLDPTILLLYGRFRCVLVCYL..LVGYLCTCYFGVFNLINRL....FRCTLGNYEYVVSSQELRYMNSHGLLPPTNSWQALMLNIKLAGIGGIPIYRVSTIQ
B1PHJ4_9ALPC/3474-3728                 ...LLYYTSSYWIKPDLITAVFVLLFGIAVMLTLT.IKHKVLFLYTFLIPSVVISACYNLA...WDL..YIRELLAKYFD.Y---.....-HMSIFSMDIQGCFNIVACILVNAIH.......TWRFVKTG..TATRLTYVLSLVVSV...YNYW.........-----.-CCGDFLSLSMMVLLNINNNWYIGAIAYRFSVVVVN---YMDPSVIRMLGGVKVILFMYV..TCGYLCCMYYGICYWFNRF....FKCTMGLYEFKVSPAEFKYMVANDLRAPTGVFDSMSLSLKLMGLGGERTIKISTVQ
A0A088DIE1_9BETC/3738-4003             .lw--EMSIFSWFAMHATIPVVILLMGVSAFVTML.VKHKHAFTTLFLMPTLAVVFYYN--...CIY..VPEHWLIEMVSkYVDLt...dTIQLFYGYSIRELIALFAVVIAMSVL.......SLRIVYDD..NTRRVWLATNVLTWL...YRLY.........AGTTV.EK---AMAYWALLMSLTTNYSGCVTVIMFAAKGVTTLIYYQFPFLGLLIAEFKFLMLVYT..CIGYLCCVYYGIFCMLNKY....LRCTFGVYPYLVSTQEFRYMNSQGLTPPTNSWDALKMNIKLSGVGGVPCIKVSNVQ
A0A0U1UZC3_9ALPC/3197-3450             ...FLMYSSVMWVHPAVVTPILLCLGLVSLMLSGL.IKHKMMFLQTFLLPSIVVIAANNFF...WDY..FVTQLLVQYFD.Y---.....-TASLFSLDIQGLLNIAMCLFVMFLH.......TYRFVSTG..-NNAIAYLSSLVVSA...YTYL.........-----.-LGGDPMYCAIMVLCSLSSEWYVGAVCYKLAIRIAP---YTSPIIATVFGTPKVIVFVYL..ALGYFTCVYWGFLYWFNRF....FKFTLGEYDFKVSPAEFKYMVANNLSAPRGPFDSLALSLRLVGVGGQRTIRISTVQ
A3EXA2_BCHK4/3625-3889                 ...LTKFTMWTYLFETIPTQMTPLLLGFMACVMFT.VKHKHTFMSLFLLPVALCLTYANIV...YEPqtLISSTLIAVAN.WLTPt...sVYMRTTHFDFGLYISL---SFVLAII.......VRRLYRPS..MSNLALALCSGVMWF...YTYV.........----I.GDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGLVFFYAPHLGFILPEVKLVLLIYL..GLGYMCTMYFGVFSLLNLK....LRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQ
A0A0K1RLM9_9ALPC/3201-3470             ...FFMYTPFTWINPTFVSIVLAVTTLISTFFVSG.IKHKMLFFMSFVLPSVILVTAHNLF...WDF..FYYEGLQSLVE.N---.....TNTMFLPVDMQGVMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVTTILVI...FNMVkifg.tsdeQWDEN.QISFCFVNMLTMIVSLTTKDWMVVVASYRIAYYIVV--CVMPSAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSVKLIGVGGKRNIKISTVQ
D9J203_9ALPC/3193-3463                 ...FFLYTPFTWFSPTMIGCILFVTVLVSTIFTAF.VKHKMLYCVSFLLPSIMLMTCSNLV...WDY.fYFEAVQAKLVE.I---.....-NISLVSIDMQSVALIILCILIACVH.......CYRFITQK..-QSIPVCLMTLCFVC...YNLVaqwyyllkgSDVGV.NLQFGYINLGMMVVCLITKDWVVVAVAYRLAYYTVF--YLIPEQFVFDFGVIKCLCVVYM..LLGYVSCCYYGILYWINRF....THMTCGVYQFCVSAAELKYMTANNLTAPTNAYEAMILSAKLVGIGGNKNIKIASVQ
A0A0U1UZ20_9ALPC/3437-3691             ...MLYYTSSYWIKPDLITPIFIILFAIAVFLTAF.VKHKVLFLYTFLVPGIVITATSNLA...WDC..YVRDLLAKYLD.Y---.....-HMSIFNMDIQGVFNIAACFMVNALH.......TWRYMRSG..YTTRVTYVVSLIVSV...YNYW.........-----.-YVGDALSLAMMLLLNVNNNWYIGACAYRFVLIVAN---YMNPAVIGFLGSFKVIMFLYV..AVGYLCCIYYGILYWLNKF....FKCTLGVYDFKVSAAEFKYMVANDLRAPCGVFDSLLLSFRLMGIGGEKTIKISTVQ
D9J202_9ALPC/3193-3463                 ...FFLYTPFTWFSPTMIGCILFVTVLVSTIFTAF.VKHKMLYCVSFLLPSIMLMTCSNLV...WDY.fYFEAVQAKLVE.I---.....-NISLVSIDMQSVALIILCILIACVH.......CYRFITQK..-QSIPVCLMTLCFVC...YNLVaqwyyllkgSDVGV.NLQFGYINLGMMVVCLITKDWVVVAVAYRLAYYTVF--YLIPEQFVFDFGVIKCLCVVYM..LLGYVSCCYYGILYWINRF....THMTCGVYQFCVSAAELKYMTANNLTAPTNAYEAMILSAKLVGIGGNKNIKIASVQ
A0A0A7UXR0_9BETC/3624-3883             ...FVKWTMFMYVTLNV-LSVTIGTLCFVACAMLF.IKHKHLYLTMFILPVFLTLLYTNYL...VVY..-KQSFRGYAYA.WLSYv...vPSVDYTYTYEVLYGCCAVLFMIFT--.......TMRSINHD..LFSIIIFITRVSSVV...SMWY.........MGSNL.EIE-----ILLLVVSIFGTYTWTTIISLTVAKAMAWWLHA-NIFYLTDIPHVKILLMCYL..LVGYIVCCYWGVFSLCNKL....FRVPLGVYNYKISVQELRYMNANGLRPPRNSFEALILNFKLIGIGGVPIIEVSQIQ
A3EXI9_BCHK9/3432-3694                 ..l-AQWTFVGALPLTLLLPLIGFVACCVGFVSLL.IKHKHTYLTVYLLPVAMVTAYYNFQ...YTP.eGVQGYLLSLYN.YVNP.....GRIDVIGTDIVTMLIISVACTL-L--.......SVRMVRTD..AYSRIWYVCTAVGWL...YNCW.........---TG.SADTVAISYLTFMVSVFTNYTGVACVSLYAAQFMVWVLKFLDPTILLLYGKFRCVLVCYL..LVGYLCTCYFGVFNLINRL....FRCTLGNYEYVVSSQELRYMNSHGLLPPTTSWQALMLNIKLAGIGGIPIYKVSTIQ
R1A_CVH22/3292-3546                    ...LFVYTTTIWVNPGFLTPFMILLVALSLCLTFV.VKHKVLFLQVFLLPSIIVAAIQNCA...WDY..HVTKVLAEKFD.Y---.....-NVSVMQMDIQGFVNIFICLFVALLH.......TWRFAKER..CTHWCTYLFSLIAVL...YTAL.........-----.-YSYDYVSLLVMLLCAISNEWYIGAIIFRICRFGVA---FLPVEYVSYFDGVKTVLLFYM..LLGFVSCMYYGLLYWINRF....CKCTLGVYDFCVSPAEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQ
H9BZX6_9BETC/3665-3924                 ...FVKWTMFMYVTTHM-LGVTLCALCFVSFAMLL.IKHKHLYLTMYIMPVLCTLFYTNYL...VVY..-KQSFRGLAYA.WLSHf...vPAVDYTYMDEVLYGVVLLFAMVFV--.......TMRSINHD..VFSIMFLVGRLVSLV...SMWY.........FGANL.EEE-----VLLFLTSLFGTYTWTTMLSLRTAKVIAKWLA-VNVLYFTDVPQIKLVLLSYL..CIGYVCCCYWGVLSLLNSI....FRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQ
B1PHJ3_9ALPC/3474-3728                 ...LLYYTSSYWIKPDLITAVFVLLFGIAVMLTLT.IKHKVLFLYTFLIPSVVISACYNLA...WDL..YIRELLAKYFD.Y---.....-HMSIFSMDIQGCFNIVACILVNAIH.......TWRFVKTG..TATRLTYVLSLVVSV...YNYW.........-----.-CCGDFLSLSMMVLLNINNNWYIGAIAYRFSVVVVN---YMDPSVIRMLGGVKVILFMYV..TCGYLCCMYYGICYWFNRF....FKCTMGLYEFKVSPAEFKYMVANDLRAPTGVFDSMSLSLKLMGLGGERTIKISTVQ
R1A_CVPPU/3205-3474                    ...FFMYTPFTWINPTFVSIVLAVTTLISTVFVSG.IKHKMLFFMSFVLPSVILVTAHNLF...WDF.sYYESLQSIVEN.T---.....-NTMFLPVDMQGVMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVTTILVI...FNMVkifg.tsdePWTEN.QIAFCFVNMLTMIVSLTTKDWMVVIASYRIAYYIVV--CVMPSAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQ
V5TFR4_9GAMC/3085-3365                 ..l-TVYASCNVVPLDMLPQLIMSVGVGFVIMFVT.LKHQHFFMTTAIIPYVVTSILGMALekpVFYngWYFSFFHDFLK.YVGIeathqYAWMLLPFALYVAYNVAKGVGSTLINfnaggisLWNSLVYG..--------MRWGSTLrflY--Talm..sdnvFETFG.SSGEFYINMHMACVGLFSSDPASGYIIMWIVKQVNY-VG-----YLAYFTELSYYTFVFYscVLCYMFSCYFGLFWFTNKV....LGTTFGKYPYKVSAGQFKYMMLNGMRGPRSTADVLITNMRLAGIGGERTITVSTVQ
H9TEX0_9ALPC/3206-3475                 ...FFMYTPFTWINPTFVSIVLAVTTLVSTVFVSG.IKHKMLFFMSFVLPSVILVTAHNLF...WDF.sYYESLQSIVEN.T---.....-NTMFLPVDMQGIMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVTTVLVI...FNMVkifg.tsdePWTEN.QIAFCFVNMLTMIVSLTTKDWMVVVASYRIAYYIVV--CVMPSAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQ
Q0PL14_9ALPC/3202-3471                 ...FFMYTPFTWINPTFVSIVLAVTTLISMFFVSG.IKHKMLFFMSFVLPSVILVTAHNLF...WDF..SYYEGLQSLVE.N---.....TNTMFLPVDMQGVMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVITILVI...FNMVkifg.tsdePWNEN.QISFCFVNMLTMIVSLTTKDWMVVVASYRIAYYIVV--CVMPSAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKTAYDAMILSAKLIGVGGKRNIKISTVQ
R9QTB2_SARS/3566-3828                  ..s-TQWSLFFFVYENAFLPFTLGIMAIAACAMLL.VKHKHAFLCLFLLPSLATVAYFN--...TVY..MPASWVMRIMT.WLEL.....ADTSLSGYRLKDCVMYASALVLLILM.......TARTVYDD..AARRVWTLMNVITLV...YKVY.........YGNSL.DQ---AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYC..FLGYCCCCYFGLFCLLNRY....FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ
A0A0U1UZA8_9ALPC/3473-3727             ...LLYYTSSYWIKPDLITAVFVLLFGIAVMLTLT.IKHKVLFLYTFLIPSVVISACYNLA...WDL..YIRELLAKYFD.Y---.....-HMSIFSMDIQGCFNIVACILVNAIH.......TWRFVKTG..TATRLTYVLSLVVSV...YNYW.........-----.-CCGDFLSLSMMVLLNINNNWYIGAIAYRFSVVVVN---YMDPSVIRMLGGVKVILFMYV..TCGYLCCMYYGICYWFNRF....FKCTMGLYEFKVSPAEFKYMVANDLRAPTGVFDSMSLSLKLMGLGGERTIKISTVQ
B6VDX7_THCOV/2814-3071                 .la--VLAMLHVLPTELYPLGLPVVTVFSSIITVT.VKHSVVFTTTFLLPAFLMFVAKAPT...LW-..IPNTYLRSLYE.WVFGl...tMSERLTCYTVGVYIVVYCLIALNY--.......TLRCVRYR..ATSYVSIFMQCVQYA...YVVH.........IVYRL.LTQAWTDKLLFTAFSLLTSHPLLAVCGWWLAGKFPVPFL---------LPDLAIQIVAYI..VIGYILCVRFGLLWILNKF....TTLPIGTYNYMVSIEQLKYMMAIKMGPPRNVFEVLVANLRLLGLGGNRNIAISTVQ
A0A0K2RVJ3_9BETC/3612-3871             ...FVKWTMFMYVTTNM-LSITFCALCVISLAMLL.VKHKHLYLTMYIIPVLFTLLYNNYL...VVY..-KQTFRGYVYA.WLSYy...vPSVEYTYTDEVIYGVLLLIGMVFV--.......TLRSINHD..LFSFIMFGGRVISVV...SLWY.........MGSNL.EEE-----ILLMLASLFGTYTWTTALSMAAAKVIAKWVA-VNVLYFTDIPQIKIVLICYL..FIGYIISCYWGLFSLMNSL....FRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ
H9TEW9_9ALPC/3206-3475                 ...FFMYTPFTWINPTFVSIVLAVTTLVSTVFVSG.IKHKMLFFMSFVLPSVILVTAHNLF...WDF.sYYESLQSIVEN.T---.....-NTMFLPVDMQGIMLTVFCFIVFVTY.......SVRFFTCK..-QSWFSLAVTTVLVI...FNMVkifg.tsdePWTEN.QIAFCFVNMLTMIVSLTTKDWMVVVASYRIAYYIVV--CVMPSAFVSDFGFMKCISIVYM..ACGYLFCCYYGILYWVNRF....TCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQ
#=GC seq_cons                          ....hhaThahal..shhhslhhslhslsshhhlh.lKHKhhFLshFLLPslhslshtNhh...hsh..hhpohlhphhs.al........ssshhshDltshhhlhhshhlhlhh.......ThRhlpsc..htshhhhlhshlshl...Ypha............th.ttt..hlshhhhllolhoshshlsshshtlAphlsh.hh.hsshhhhhhsplKhlhlsYh..slGYlsCCYaGlhhhlN+h....h+hoLGVYsYpVSspEa+YMsANGLpsP+sua-AhhLNhKLlGIGGp.sIKVSTVQ
//
DBGET integrated database retrieval system