GenomeNet

Database: Pfam
Entry: CoV_NSP7
LinkDB: CoV_NSP7
Original site: CoV_NSP7 
#=GF ID   CoV_NSP7
#=GF AC   PF08716.12
#=GF DE   Coronavirus replicase NSP7
#=GF PI   nsp7;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   pdb_1ysy
#=GF GA   25.00 25.00;
#=GF TC   25.20 38.90;
#=GF NC   22.10 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16188992
#=GF RT   Structural genomics of the severe acute respiratory syndrome
#=GF RT   coronavirus: nuclear magnetic resonance structure of the protein
#=GF RT   nsP7. 
#=GF RA   Peti W, Johnson MA, Herrmann T, Neuman BW, Buchmeier MJ, Nelson
#=GF RA   M, Joseph J, Page R, Stevens RC, Kuhn P, Wuthrich K; 
#=GF RL   J Virol. 2005;79:12905-12913.
#=GF RN   [2]
#=GF RM   16228002
#=GF RT   Insights into SARS-CoV transcription and replication from the
#=GF RT   structure of the nsp7-nsp8 hexadecamer. 
#=GF RA   Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, Rao Z; 
#=GF RL   Nat Struct Mol Biol. 2005;12:980-986.
#=GF RN   [3]
#=GF RM   31138817
#=GF RT   Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and
#=GF RT   nsp8 co-factors.
#=GF RA   Kirchdoerfer RN, Ward AB;
#=GF RL   Nat Commun. 2019;10:2342.
#=GF DR   INTERPRO; IPR014828;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   NSP7 (non structural protein 7) has been implicated in viral RNA
#=GF CC   replication and is predominantly alpha helical in structure [1].
#=GF CC   It forms a hexadecameric supercomplex with NSP8 that adopts a
#=GF CC   hollow cylinder-like structure [2]. The dimensions of the
#=GF CC   central channel and positive electrostatic properties of the
#=GF CC   cylinder imply that it confers processivity on RNA-dependent RNA
#=GF CC   polymerase [2]. NSP7 and NSP8 heterodimers play a role in the
#=GF CC   stabilisation of NSP12 regions involved in RNA binding and are
#=GF CC   essential for a highly active NSP12 polymerase complex [3].
#=GF SQ   105
#=GS Q6UZF5_SARS/3837-3919       AC Q6UZF5.1
#=GS A0A0K1YZY7_SARS/3837-3919   AC A0A0K1YZY7.1
#=GS A0A1B3Q5W8_9BETC/3742-3824  AC A0A1B3Q5W8.1
#=GS B8Q8S5_SARS/3837-3919       AC B8Q8S5.1
#=GS R1AB_IBVB/3380-3462         AC P0C6Y1.1
#=GS R1A_BCHK9/3700-3782         AC P0C6T6.1
#=GS T2B9I2_MERS/3846-3928       AC T2B9I2.1
#=GS H9BZX6_9BETC/3925-4013      AC H9BZX6.1
#=GS A0A0F6WGL5_9GAMC/3410-3492  AC A0A0F6WGL5.1
#=GS H9AA60_9BETC/3858-3946      AC H9AA60.1
#=GS R1AB_FIPV/3500-3582         AC Q98VG9.2
#=GS R1AB_FIPV/3500-3582         DR PDB; 3UB0 F; 1-77;
#=GS R1AB_FIPV/3500-3582         DR PDB; 3UB0 C; 1-81;
#=GS R1AB_FIPV/3500-3582         DR PDB; 3UB0 E; 2-82;
#=GS R1AB_FIPV/3500-3582         DR PDB; 3UB0 B; 2-83;
#=GS H9BZX5_9BETC/3925-4013      AC H9BZX5.1
#=GS A0A0U1UZ65_BCHK4/3898-3980  AC A0A0U1UZ65.1
#=GS S5Z1D1_9ALPC/3622-3704      AC S5Z1D1.1
#=GS A0A0K1Z0N1_SARS/3837-3919   AC A0A0K1Z0N1.1
#=GS H9TEX0_9ALPC/3476-3558      AC H9TEX0.1
#=GS E0ZN59_BCHK9/3675-3757      AC E0ZN59.1
#=GS C0KYZ6_9BETC/3927-4015      AC C0KYZ6.1
#=GS R1AB_BCHK5/3937-4019        AC P0C6W4.1
#=GS Q06BE1_9BETC/3837-3925      AC Q06BE1.2
#=GS A0A0U2UMS4_9ALPC/3473-3555  AC A0A0U2UMS4.1
#=GS A0A1X9JQL5_9ALPC/3438-3520  AC A0A1X9JQL5.1
#=GS F2YDB1_SARS/3837-3919       AC F2YDB1.1
#=GS B8Q8U7_SARS/3837-3919       AC B8Q8U7.1
#=GS A0A0F6SKM6_9GAMC/3410-3492  AC A0A0F6SKM6.1
#=GS S5YAF0_9ALPC/3622-3704      AC S5YAF0.1
#=GS A0A0U1UZA8_9ALPC/3728-3810  AC A0A0U1UZA8.1
#=GS R1AB_CVH22/3547-3629        AC P0C6X1.1
#=GS H9BR16_9NIDO/3071-3153      AC H9BR16.1
#=GS B1PHK0_9ALPC/3692-3774      AC B1PHK0.1
#=GS R1A_CVM2/3870-3958          AC P0C6U9.1
#=GS B1PHJ4_9ALPC/3729-3811      AC B1PHJ4.1
#=GS D9J203_9ALPC/3464-3546      AC D9J203.1
#=GS U5KNA9_9BETC/3909-3991      AC U5KNA9.1
#=GS R1A_SARS2/3860-3942         AC P0DTC1.1
#=GS A0A0U1WHG4_9ALPC/3538-3620  AC A0A0U1WHG4.1
#=GS A0A0U1WHG1_9ALPC/3396-3478  AC A0A0U1WHG1.1
#=GS A8JNZ1_9ALPC/3522-3604      AC A8JNZ1.1
#=GS A3EXI9_BCHK9/3695-3777      AC A3EXI9.1
#=GS V5TFR4_9GAMC/3366-3448      AC V5TFR4.1
#=GS R1AB_CVM2/3870-3958         AC P0C6X8.1
#=GS R1A_CVPPU/3475-3557         AC P0C6V2.1
#=GS B2BW31_9GAMC/3366-3448      AC B2BW31.1
#=GS R1A_BCHK5/3937-4019         AC P0C6T5.1
#=GS A3EXE7_BCHK5/3936-4018      AC A3EXE7.1
#=GS E0XIZ2_9BETC/3828-3910      AC E0XIZ2.1
#=GS A0A023YA54_MERS/3947-4029   AC A0A023YA54.1
#=GS A3EXA2_BCHK4/3890-3972      AC A3EXA2.1
#=GS R9QTB2_SARS/3829-3911       AC R9QTB2.1
#=GS R1AB_SARS2/3860-3942        AC P0DTD1.1
#=GS R1AB_SARS2/3860-3942        DR PDB; 7BTF C; 1-68;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6WQD C; 1-71;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6XIP C; 1-73;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6M71 C; 2-71;
#=GS R1AB_SARS2/3860-3942        DR PDB; 7BV2 C; 2-64;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6WQD A; 1-71;
#=GS R1AB_SARS2/3860-3942        DR PDB; 7BW4 C; 1-65;
#=GS R1AB_SARS2/3860-3942        DR PDB; 7BZF C; 1-68;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6YYT C; 1-73;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6WTC C; 1-72;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6WTC A; 1-73;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6M5I A; 1-81;
#=GS R1AB_SARS2/3860-3942        DR PDB; 7BV1 C; 2-64;
#=GS R1AB_SARS2/3860-3942        DR PDB; 7C2K C; 1-72;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6WIQ A; 1-79;
#=GS R1AB_SARS2/3860-3942        DR PDB; 6XIP A; 1-70;
#=GS R1AB_CVHOC/3837-3925        AC P0C6X6.1
#=GS D9J202_9ALPC/3464-3546      AC D9J202.1
#=GS A0A0K1RLM9_9ALPC/3471-3553  AC A0A0K1RLM9.1
#=GS B1PHI6_9ALPC/3785-3867      AC B1PHI6.1
#=GS A0A088DIE1_9BETC/4004-4086  AC A0A088DIE1.1
#=GS R1AB_SARS/3837-3919         AC P0C6X7.1
#=GS R1AB_SARS/3837-3919         DR PDB; 2AHM C; 6-78;
#=GS R1AB_SARS/3837-3919         DR PDB; 2AHM D; 6-76;
#=GS R1AB_SARS/3837-3919         DR PDB; 2AHM B; 6-79;
#=GS R1AB_SARS/3837-3919         DR PDB; 1YSY A; 3-85;
#=GS R1AB_SARS/3837-3919         DR PDB; 2AHM A; 6-78;
#=GS R1AB_SARS/3837-3919         DR PDB; 6NUR C; 2-71;
#=GS R1A_IBVB/3380-3462          AC P0C6V3.1
#=GS R1A_BCHK4/3890-3972         AC P0C6T4.1
#=GS K4K1U5_9ALPC/3576-3658      AC K4K1U5.1
#=GS A0A0U1WHD1_9ALPC/3685-3767  AC A0A0U1WHD1.1
#=GS Q0PL14_9ALPC/3472-3554      AC Q0PL14.1
#=GS A0A0A7UXR0_9BETC/3884-3972  AC A0A0A7UXR0.1
#=GS A8JNZ0_9ALPC/3522-3604      AC A8JNZ0.1
#=GS A0A0P0ILY9_CVH22/3552-3634  AC A0A0P0ILY9.1
#=GS A0A0K2RW65_9BETC/3872-3960  AC A0A0K2RW65.1
#=GS U5LR11_9BETC/3909-3991      AC U5LR11.1
#=GS R1AB_BC512/3591-3673        AC P0C6W0.1
#=GS A0A0U1WHK4_SARS/3837-3919   AC A0A0U1WHK4.1
#=GS R1A_BC512/3591-3673         AC P0C6F6.1
#=GS R1AB_CVPPU/3475-3557        AC P0C6Y5.1
#=GS R1AB_BCHK4/3890-3972        AC P0C6W3.1
#=GS B8Q8S4_SARS/3837-3919       AC B8Q8S4.1
#=GS R1AB_BCHK9/3700-3782        AC P0C6W5.1
#=GS R1A_BC279/3843-3925         AC P0C6F5.1
#=GS B1PHI7_9ALPC/3785-3867      AC B1PHI7.1
#=GS E0ZN51_BCHK9/3695-3777      AC E0ZN51.1
#=GS B7U2M9_9BETC/3837-3925      AC B7U2M9.1
#=GS R1A_CVHOC/3837-3925         AC P0C6U7.1
#=GS R1AB_CVMA5/3922-4010        AC P0C6X9.1
#=GS R1AB_CVMJH/3928-4016        AC P0C6Y0.1
#=GS A0A0U1WHG0_SARS/3832-3914   AC A0A0U1WHG0.1
#=GS A0A0P0LKV0_CVH22/3552-3634  AC A0A0P0LKV0.1
#=GS R1A_CVH22/3547-3629         AC P0C6U2.1
#=GS B1PHJ3_9ALPC/3729-3811      AC B1PHJ3.1
#=GS B1PHK1_9ALPC/3692-3774      AC B1PHK1.1
#=GS A0A240FW17_9ALPC/3132-3213  AC A0A240FW17.1
#=GS A0A0K2RVJ3_9BETC/3872-3960  AC A0A0K2RVJ3.1
#=GS R1A_SARS/3837-3919          AC P0C6U8.1
#=GS R1A_SARS/3837-3919          DR PDB; 2KYS A; 3-85;
#=GS R1A_SARS/3837-3919          DR PDB; 5F22 A; 6-84;
#=GS F2YDB2_SARS/3837-3919       AC F2YDB2.1
#=GS A3EXC0_BCHK4/3900-3982      AC A3EXC0.1
#=GS Q0ZJB1_CVHK1/3924-4012      AC Q0ZJB1.1
#=GS B8Q8U6_SARS/3837-3919       AC B8Q8U6.1
#=GS A0A096XNJ3_9ALPC/3542-3624  AC A0A096XNJ3.2
#=GS A0A059VJE6_9ALPC/3580-3662  AC A0A059VJE6.1
#=GS A0A125R5A4_9ALPC/3487-3569  AC A0A125R5A4.1
#=GS Q9J3E9_9BETC/3921-4009      AC Q9J3E9.1
#=GS A0A125R5A3_9ALPC/3487-3569  AC A0A125R5A3.1
#=GS A0A0U1UZC3_9ALPC/3451-3533  AC A0A0U1UZC3.1
#=GS A0A0U1UZ20_9ALPC/3692-3774  AC A0A0U1UZ20.1
#=GS T2B9U0_MERS/3846-3928       AC T2B9U0.1
#=GS R1AB_BC279/3843-3925        AC P0C6V9.1
#=GS R1A_CVMA5/3922-4010         AC P0C6V0.1
#=GS H9TEW9_9ALPC/3476-3558      AC H9TEW9.1
#=GS B2BW32_9GAMC/3366-3448      AC B2BW32.1
#=GS R1A_CVMJH/3928-4016         AC P0C6V1.1
Q6UZF5_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
A0A0K1YZY7_SARS/3837-3919              ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTAAFEKMVSLLSVLLSMQGAVD......ISKLCEEMLDNRATLQ.
A0A1B3Q5W8_9BETC/3742-3824             ..SNMTDLKCTSVVLLSVLQQLHVESSSKLWSLCVKLHNEILAATSTTDAFEAFVSLLSVLLSLPGAIN......LDELCNSILENNTVLQ.
B8Q8S5_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
R1AB_IBVB/3380-3462                    .a-KLSDVKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTID......LSEYCDDILKRSTVLQ.
R1A_BCHK9/3700-3782                    ..SNMTDLKCTSVVLLSVLQQLRVESSSKLWALCVKLHNEILASNSPTEAFEAFVSLLSVLLSLPGAIN......LDELCSSILENNSVLQ.
T2B9I2_MERS/3846-3928                  ..SKLTDLKCTSVVLLSVLQQLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVD......LDALASDIFDTPSVLQ.
H9BZX6_9BETC/3925-4013                 ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
A0A0F6WGL5_9GAMC/3410-3492             ..SKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVGLHNKILASDDVNECMDNLLGMLVTLFCVDSTID......LSEYCDDILKRSTVLQ.
H9AA60_9BETC/3858-3946                 ..SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLSTAFEKLAQLLIVLFANPAAVDskclssIEEVCDDYAKDNTVLQ.
R1AB_FIPV/3500-3582                    ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPDAVLEKLLALIAFFLSKHNTCD......LSDLIESYFENTTILQ.
#=GR R1AB_FIPV/3500-3582         SS    ..TTHHHHHHHHHHHHHHHHHTTGGGSHHHHHHHHHHHHHHHH-S-HHHHHHHHHHHHHHHHHCSTCHH......HHHHHHHHCHH-CCG-.
H9BZX5_9BETC/3925-4013                 ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
A0A0U1UZ65_BCHK4/3898-3980             ..SKLTDLKCTSVVLLTVLQQLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVD......LDALANDLFENSSVLQ.
S5Z1D1_9ALPC/3622-3704                 ..SKLTDVKCTNVVLMGCLSSMNIQANSAEWNYCVDLHNKINLCNDLERAQEYLLALLAFFLSKNSAFG......LDDLLDSYFDNNTVLQ.
A0A0K1Z0N1_SARS/3837-3919              ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTAAFEKMVSLLSVLLSMQGAVD......ISKLCEEMLDNRATLQ.
H9TEX0_9ALPC/3476-3558                 ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCD......LSELIESYFENTTILQ.
E0ZN59_BCHK9/3675-3757                 ..SNMTDLKCTSVVLLSVLQQLRVEASSKLWSLCVKLHNEILASSSPSEAFEAFVSLLSVLLSLPGAIN......LDELCNSILENNTVLQ.
C0KYZ6_9BETC/3927-4015                 ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
R1AB_BCHK5/3937-4019                   ..SKLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDNFVCLFATLMSFSANVD......LEALASDLLDHPSVLQ.
Q06BE1_9BETC/3837-3925                 ..SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFANPAAVDskcltsIEEVCDDYAKDNTVLQ.
A0A0U2UMS4_9ALPC/3473-3555             ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCEDPEIVLEKLLALIAFFLSKHNTCD......LSELIDSYFENTTILQ.
A0A1X9JQL5_9ALPC/3438-3520             ..SKLTDLKCTNVVLLSCLSSMNVAVNSKEWSYCVQLHNDINLCDDPETATEKLLALCSFFLSKQQNFN......LDVLIDSYFDNKAIL-h
F2YDB1_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
B8Q8U7_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
A0A0F6SKM6_9GAMC/3410-3492             ..SKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVGLHNKILASDDVNECMDNLLGMLVTLFCVDSTID......LSEYCDDILKRSTVLQ.
S5YAF0_9ALPC/3622-3704                 ..SKLTDVKCTNVVLMGCLSSMNIQANSAEWNYCVDLHNKINLCNDLERAQEYLLALLAFFLSKNSAFG......LDDLLDSYFDNNTVLQ.
A0A0U1UZA8_9ALPC/3728-3810             ..SKLTDIKCTNVVLMGCLSSMNIEANSKKWSYCVDLHNKINLCDDAEKAMEYLLALVTFFISEHADFN......VSELVDSYFGDNSILQ.
R1AB_CVH22/3547-3629                   ..SKLTDLKCTNVVLMGILSNMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFG......LGDLVDSYFENDSILQ.
H9BR16_9NIDO/3071-3153                 nk--TLDIKATAVIIAQLLEKVGVTNKTEMCKKITQLHNKVLASKTAEEAEPHLYALLVYLLPHFSSDN......LDKYFDSLLQHKPVLQ.
B1PHK0_9ALPC/3692-3774                 ..SKLTEIKCTNVVLMGVLTSMNIEANSKDWAFCVDLHNKINLSTDAEKAMEYLLALLTFFLSRQKDFN......CTELLDSYFADSSILQ.
R1A_CVM2/3870-3958                     ..SRLTDVKCVNVVLLNCLQHLHIASSSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDSTVLQ.
B1PHJ4_9ALPC/3729-3811                 ..SKLTDIKCTNVVLMGCLSSMNIEANSKKWSYCVDLHNKINLCDDAEKAMEYLLALVTFFISEHADFN......VSELVDSYFGDNSILQ.
D9J203_9ALPC/3464-3546                 ..SKLTDMKCTNVVLLGLLSKMHVEANSKEWNYCVTLHNEINLSDDPDVVLNKLLALLAFFLSKHNNCD......LSELIESYFDNTSVL-h
U5KNA9_9BETC/3909-3991                 ..SKLTDLKCTSVVLLSVLQQLHLEANSKAWSHCVKLHNDILSTSDPSEAFEKFVALLATLMSFSGSVD......LEALASELLDNISVLQ.
R1A_SARS2/3860-3942                    ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
A0A0U1WHG4_9ALPC/3538-3620             ..SKLTDIKCTNVVLLGCLSSMNIASHTKEWSYCVELHNKINLCDDPEKAQEMLLALLAFFLSKQKDFG......VDDLLESYFSSGSILQ.
A0A0U1WHG1_9ALPC/3396-3478             ..SKLTDLKCANVVLLGCLSAMNVSANSKEWAYCVDLHNKINLCDDPEKAQEMLLALLAFFISKQKDFG......VDDLLDSYFSNSALLQ.
A8JNZ1_9ALPC/3522-3604                 ..SKLTDLKCANVVLLGCLTNMNIAANSREWSYCVNLHNEINLTSDPEEALEKLLALVAFFLSKQQNFG......VDDLIDSFFENRNVLQ.
A3EXI9_BCHK9/3695-3777                 ..SNMTDLKCTSVVLLSVLQQLRVESSSKLWALCVRLHNEILASNSPTEAFEAFVSLLSVLLSLPGAIN......LDELCSSILENNSVLQ.
V5TFR4_9GAMC/3366-3448                 ..SKLTDVKCATVVLMQLLTKLNVEANSRLHKHLVQTHNDILAESDPAICIEKLTGMLMTLLSIDSTLD......VKALCDELLAKESVLQ.
R1AB_CVM2/3870-3958                    ..SRLTDVKCVNVVLLNCLQHLHIASSSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDSTVLQ.
R1A_CVPPU/3475-3557                    ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCD......LSELIESYFENTTILQ.
B2BW31_9GAMC/3366-3448                 ..SKLTDVKCATVVLMQLLTKLNVEANSRLHKHLVQTHNDILAESDPAICIEKLTGMLMTLLSIDSTLD......VKALCDELLAKESVLQ.
R1A_BCHK5/3937-4019                    ..SKLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDNFVCLFATLMSFSANVD......LEALASDLLDHPSVLQ.
A3EXE7_BCHK5/3936-4018                 ..SKLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDKLVCLFATLMSFPANVD......LEALASDLLDHPSVLQ.
E0XIZ2_9BETC/3828-3910                 ..SKMSDIKCTSVVLLSVLQQLRIESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCDEMLNNRATLQ.
A0A023YA54_MERS/3947-4029              ..SKLTDLKCTSVVLLSVLQQLHLEANSKAWAYCVKCHNDILTAVDPTEAFEKFVCLFATLMTFSGNVD......LDGLASDLFENSAVLQ.
A3EXA2_BCHK4/3890-3972                 ..SKLTDLKCTSVVLLTVLQQLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVD......LDALANDLFENSSVLQ.
R9QTB2_SARS/3829-3911                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
R1AB_SARS2/3860-3942                   ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
#=GR R1AB_SARS2/3860-3942        SS    ..HHHHHHHHHHHHHHHHHHHTTGGGSHHHHHHHHHHHHHHHT-SSHHHHHHHHHHHHHHHHTSTTTSS......HHHHHHHHHCTSXXXX.
R1AB_CVHOC/3837-3925                   ..SKLTDVKCANVVLLNCLQHLHVASNSKLWHYCSTLHNEILATSDLSVAFEKLAQLLIVLFANPAAVDskcltsIEEVCDDYAKDNTVLQ.
D9J202_9ALPC/3464-3546                 ..SKLTDMKCTNVVLLGLLSKMHVEANSKEWNYCVTLHNEINLSDDPDVVLNKLLALLAFFLSKHNNCD......LSELIESYFDNTSVL-h
A0A0K1RLM9_9ALPC/3471-3553             ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCD......LSELIESYFENTTILQ.
B1PHI6_9ALPC/3785-3867                 ..SKLTDIKCTNVVLMGCLSSMNIEANSKKWSYCVDLHNKINLCDDAEKAMEYLLALVTFFISEHADFN......VSELVDSYFGDNSILQ.
A0A088DIE1_9BETC/4004-4086             ..SKMSDIKCTSVVLLSVLQQLRIEANSRIWSLCVTLHNDILLAKDATEAFEKLTTLLSVLLSMPGAVD......LTKLCDDVFENPAILQ.
R1AB_SARS/3837-3919                    ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
#=GR R1AB_SARS/3837-3919         SS    ..HHHHHHHHHHHHHHHHHHHTTGGGSHHHHHHHHHHHHHHHTSSSHHHHHHHHHHHHHHHHHHHCCCH......HHCCHHTTTHHHHSXX.
R1A_IBVB/3380-3462                     .a-KLSDVKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTID......LSEYCDDILKRSTVLQ.
R1A_BCHK4/3890-3972                    ..SKLTDLKCTSVVLLTVLQQLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVD......LDALANDLFENSSVLQ.
K4K1U5_9ALPC/3576-3658                 ..SKLTDIKCTNVVLLGCLSSMNIAANTKEWSYCVDLHNKINLCNDPEAAQEMLLALLAFFLSKHKDFG......FDDLLDSYFADNSILQ.
A0A0U1WHD1_9ALPC/3685-3767             ..SKLTEIKCTNVVLMGVLTSMNIEANSKDWAFCVELHNKINLADDAEKAMEYLLTLLTFFLSRQKDFN......CTELLDSYFADSSVLQ.
Q0PL14_9ALPC/3472-3554                 ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCD......LSELVESYFENTTILQ.
A0A0A7UXR0_9BETC/3884-3972             ..SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFDKLAQLLIVLFANPAAVDtkcltsIEDVCDDYVRDNTVLQ.
A8JNZ0_9ALPC/3522-3604                 ..SKLTDLKCANVVLLGCLTNMNIAANSREWSYCVNLHNEINLTSDPEEALEKLLALVAFFLSKQQNFG......VDDLIDSFFENRNVLQ.
A0A0P0ILY9_CVH22/3552-3634             ..SKLTDLKCTNVVLMGILSNMNIAANSKEWAYCVETHNKINLCDDPETAQELLLALLAFFLSKHSDFG......LGDLVDSYFENDSILQ.
A0A0K2RW65_9BETC/3872-3960             ..SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFANPAAVDskcltsIEEVCDDYAKDNTVLQ.
U5LR11_9BETC/3909-3991                 ..SKLTDLKCTSVVLLSVLQQLHLEANSKAWSHCVKLHNDILSTSDPSEAFEKFVALLATLMSFSGSVD......LEALASELLDNISVLQ.
R1AB_BC512/3591-3673                   ..SKLTDLKCTNVVLLGCLSNMNIAANSREWAYCVDLHNKINLCNDAEAAQEMLLALLAFFLSKNSAFG......VDELLDSYFNDSSVLQ.
A0A0U1WHK4_SARS/3837-3919              ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
R1A_BC512/3591-3673                    ..SKLTDLKCTNVVLLGCLSNMNIAANSREWAYCVDLHNKINLCNDAEAAQEMLLALLAFFLSKNSAFG......VDELLDSYFNDSSVLQ.
R1AB_CVPPU/3475-3557                   ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCD......LSELIESYFENTTILQ.
R1AB_BCHK4/3890-3972                   ..SKLTDLKCTSVVLLTVLQQLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVD......LDALANDLFENSSVLQ.
B8Q8S4_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
R1AB_BCHK9/3700-3782                   ..SNMTDLKCTSVVLLSVLQQLRVESSSKLWALCVKLHNEILASNSPTEAFEAFVSLLSVLLSLPGAIN......LDELCSSILENNSVLQ.
R1A_BC279/3843-3925                    ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
B1PHI7_9ALPC/3785-3867                 ..SKLTDIKCTNVVLMGCLSSMNIEANSKKWSYCVDLHNKINLCDDAEKAMEYLLALVTFFISEHADFN......VSELVDSYFGDNSILQ.
E0ZN51_BCHK9/3695-3777                 ..SNMTDLKCTSVVLLSVLQQLRVESSSKLWALCVKLHNEILASSSPTEAFEAFVSLLSVLLSLPGAIN......LDELCGSILENNSVLQ.
B7U2M9_9BETC/3837-3925                 ..SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFANPAAVDskcltsIEEVCDDYAKDNTVLQ.
R1A_CVHOC/3837-3925                    ..SKLTDVKCANVVLLNCLQHLHVASNSKLWHYCSTLHNEILATSDLSVAFEKLAQLLIVLFANPAAVDskcltsIEEVCDDYAKDNTVLQ.
R1AB_CVMA5/3922-4010                   ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
R1AB_CVMJH/3928-4016                   ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
A0A0U1WHG0_SARS/3832-3914              ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWARCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
A0A0P0LKV0_CVH22/3552-3634             ..SKLTDLKCTNVVLMGILSNMNIAANSKEWAYCVETHNKINLCDDPETAQELLLALLAFFLSKHSDFG......LGDLVDSYFENDSILQ.
R1A_CVH22/3547-3629                    ..SKLTDLKCTNVVLMGILSNMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFG......LGDLVDSYFENDSILQ.
B1PHJ3_9ALPC/3729-3811                 ..SKLTDIKCTNVVLMGCLSSMNIEANSKKWSYCVDLHNKINLCDDAEKAMEYLLALVTFFISEHADFN......VSELVDSYFGDNSILQ.
B1PHK1_9ALPC/3692-3774                 ..SKLTEIKCTNVVLMGVLTSMNIEANSKDWAFCVDLHNKINLSTDAEKAMEYLLALLTFFLSRQKDFN......CTELLDSYFADSSILQ.
A0A240FW17_9ALPC/3132-3213             ..SKLTDIKCCNVVLLGLLNNLGVSANSKEWNWCVSMHNKICLSNDE-SVVESLLALVLFFMSKCKNVD......LDALLDVYFDNNSILQ.
A0A0K2RVJ3_9BETC/3872-3960             ..SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFANPAAVDskcltsIEEVCDDYAKDNTVLQ.
R1A_SARS/3837-3919                     ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
#=GR R1A_SARS/3837-3919          SS    ..SCHHHHCHHHHHHHHHHHCTTGGCTCCHHHHHHHHHHHHHCSSSCHHHHHHHCCCHHHHHCHTTSST......HHHHHHHHCHHHHTTX.
F2YDB2_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
A3EXC0_BCHK4/3900-3982                 ..SKLTDLKCTSVVLLTVLQQLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVD......LDALANDLFENSSVLQ.
Q0ZJB1_CVHK1/3924-4012                 ..SKLTDVKCANVVLLNCLQHLHVASNSRLWQYCSILHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDtkclasIDEVSDDYVQDSTVLQ.
B8Q8U6_SARS/3837-3919                  ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INRLCEEMLDNRATLQ.
A0A096XNJ3_9ALPC/3542-3624             ..SKLTDLKCTNVVLLSCLSSMNVAVNSKEWSYCVQLHNDINLCDDPEKATEKLLALCSFFLSKQQNFN......LDALIDSYFDNKAIL-h
A0A059VJE6_9ALPC/3580-3662             ..SKLTDIKCSNVVLLGCLSSMNVSANSTEWAYCVDLHNKINLCNDPEKAQEMLLALLAFFLSKNSAFG......LDDLLESYFNDNSMLQ.
A0A125R5A4_9ALPC/3487-3569             ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEVVLEKLLALIAFFLSKHNTCD......LSDLIDSYFENTTILQ.
Q9J3E9_9BETC/3921-4009                 ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
A0A125R5A3_9ALPC/3487-3569             ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEVVLEKLLALIAFFLSKHNTCD......LSDLIDSYFENTTILQ.
A0A0U1UZC3_9ALPC/3451-3533             ..SKLTDLKCANVVLLGCLSSMNIASNSKDWEYCVTLHNKINLCDDPEKAHEMLLALLAFFLSKQQAFG......IDGLVDSYFDSNSMLQ.
A0A0U1UZ20_9ALPC/3692-3774             ..SKLTEIKCTNVVLMGVLTSMNIEANSKDWAFCVDLHNKINLSTDAEKAMEYLLALLTFFLSRQKDFN......CTELLDSYFADSSILQ.
T2B9U0_MERS/3846-3928                  ..SKLTDLKCTSVVLLSVLQQLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVD......LDALASDIFDTPSVLQ.
R1AB_BC279/3843-3925                   ..SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD......INKLCEEMLDNRATLQ.
R1A_CVMA5/3922-4010                    ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
H9TEW9_9ALPC/3476-3558                 ..SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCD......LSELIESYFENTTILQ.
B2BW32_9GAMC/3366-3448                 ..SKLTDVKCATVVLMQLLTKLNVEANSRLHKHLVQTHNDILAESDPAICIEKLTGMLMTLLSIDSTLD......VKALCDELLAKESVLQ.
R1A_CVMJH/3928-4016                    ..SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDskclasIEEVSDDYVRDNTVLQ.
#=GC SS_cons                           ..HHHHHHHHHHHHHHHHHHHTTGGGSHHHHHHHHHHHHHHHTSSSHHHHHHHHHHHHHHHHHHTTCSH......HHHHHHHHCHHHHCCX.
#=GC seq_cons                          ..SKLTDlKCTsVVLLulLppL+lEuNSKhWuYCVpLHN-ILhssDsspAhEKLluLLusLlShpuslD......ls-Ls-shhcssolLQ.
//
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