GenomeNet

Database: Pfam
Entry: CoV_S2_C
LinkDB: CoV_S2_C
Original site: CoV_S2_C 
#=GF ID   CoV_S2_C
#=GF AC   PF19214.3
#=GF DE   Coronavirus spike glycoprotein S2, intravirion
#=GF PI   Corona_Spike_C; Corona_S2_C;
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Bateman A
#=GF GA   27.00 27.00;
#=GF TC   27.50 27.50;
#=GF NC   26.80 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19801669
#=GF RT   Role of spike protein endodomains in regulating coronavirus
#=GF RT   entry.
#=GF RA   Shulla A, Gallagher T;
#=GF RL   J Biol Chem. 2009;284:32725-32734.
#=GF DR   INTERPRO; IPR043614;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the cysteine rich intravirion region found
#=GF CC   at the C-terminus of coronavirus spike proteins (S) [1]. These
#=GF CC   cysteine residues are targets for palmitoylation, necessary for
#=GF CC   efficiently S incorporation into virions and S-mediated membrane
#=GF CC   fusions.
#=GF SQ   63
#=GS A3EXJ0_BCHK9/1232-1272      AC A3EXJ0.1
#=GS A0A1B3Q5W5_9BETC/1250-1290  AC A0A1B3Q5W5.1
#=GS A0A023PMV0_9GAMC/1113-1162  AC A0A023PMV0.1
#=GS SPIKE_CVMA5/1285-1322       AC P11224.2
#=GS I1VWF5_CVH22/1131-1169      AC I1VWF5.1
#=GS A0A0U1WHB7_9ALPC/1339-1376  AC A0A0U1WHB7.1
#=GS A0A0U1WHD9_9ALPC/1342-1378  AC A0A0U1WHD9.1
#=GS A0A023Y9K3_MERS/1285-1322   AC A0A023Y9K3.1
#=GS K4JZP8_9ALPC/1315-1351      AC K4JZP8.1
#=GS R9UQ53_MERS/1316-1353       AC R9UQ53.1
#=GS SPIKE_IBVB/1113-1162        AC P11223.1
#=GS C6GHE6_9ALPC/1433-1472      AC C6GHE6.1
#=GS SPIKE_BCHK4/1317-1352       AC A3EX94.1
#=GS A0A0U1WHB6_9ALPC/1342-1378  AC A0A0U1WHB6.1
#=GS B1PHK2_9ALPC/1339-1375      AC B1PHK2.1
#=GS SPIKE_BC512/1332-1371       AC Q0Q466.1
#=GS A0A088DJY6_9BETC/1281-1316  AC A0A088DJY6.1
#=GS A0A2H4MXZ6_9NIDO/1184-1221  AC A0A2H4MXZ6.1
#=GS SPIKE_CVP67/1313-1348       AC Q8BB25.1
#=GS A0A0S2ZWY7_9GAMC/1149-1198  AC A0A0S2ZWY7.1
#=GS A0A0U1WHB3_9ALPC/1338-1375  AC A0A0U1WHB3.1
#=GS A0A172AZS6_9ALPC/1397-1438  AC A0A172AZS6.1
#=GS A0A1L2KGB2_9ALPC/1332-1372  AC A0A1L2KGB2.1
#=GS A0A1X9JJW0_9ALPC/1090-1126  AC A0A1X9JJW0.1
#=GS A0A140ESF1_9NIDO/1118-1160  AC A0A140ESF1.1
#=GS C0KYU0_9BETC/1337-1374      AC C0KYU0.1
#=GS A0A0U1WHD7_9ALPC/1346-1387  AC A0A0U1WHD7.1
#=GS A0A0U1WJW4_9ALPC/1092-1132  AC A0A0U1WJW4.1
#=GS SPIKE_BCHK5/1317-1352       AC A3EXD0.1
#=GS U5LNM4_9BETC/1294-1330      AC U5LNM4.1
#=GS S5YNL4_9ALPC/1325-1364      AC S5YNL4.1
#=GS E3W5J0_9ALPC/1426-1465      AC E3W5J0.1
#=GS SPIKE_BCHK9/1232-1274       AC A3EXG6.1
#=GS SPIKE_CVH22/1135-1173       AC P15423.1
#=GS A0A0F6YS09_9GAMC/1142-1191  AC A0A0F6YS09.1
#=GS A0A1L7HJ82_9ALPC/1098-1134  AC A0A1L7HJ82.1
#=GS H9BR17_9NIDO/1199-1254      AC H9BR17.1
#=GS H9BR25_9NIDO/1162-1212      AC H9BR25.1
#=GS A3EXI2_BCHK9/1229-1269      AC A3EXI2.1
#=GS H9BR35_9NIDO/1170-1214      AC H9BR35.1
#=GS D9J204_9ALPC/1387-1429      AC D9J204.1
#=GS SPIKE_BC133/1315-1350       AC Q0Q4F2.1
#=GS A0A0K2RVL1_9BETC/1327-1362  AC A0A0K2RVL1.1
#=GS I7B987_9BETC/1196-1233      AC I7B987.1
#=GS B7U2M2_9BETC/1327-1362      AC B7U2M2.1
#=GS A0A240FW18_9ALPC/1101-1134  AC A0A240FW18.1
#=GS A0A060A825_9NIDO/1118-1160  AC A0A060A825.1
#=GS SPIKE_CVPPU/1408-1447       AC P07946.2
#=GS SPIKE_FIPV/1413-1452        AC P10033.1
#=GS B7U2N3_9BETC/1327-1362      AC B7U2N3.1
#=GS A0A0U1WJW2_9ALPC/1333-1370  AC A0A0U1WJW2.1
#=GS A0A4D6FWE9_9GAMC/1135-1184  AC A0A4D6FWE9.1
#=GS A8JNZ2_9ALPC/1088-1128      AC A8JNZ2.1
#=GS B1PHI8_9ALPC/1338-1384      AC B1PHI8.1
#=GS H9TEX4_9ALPC/1415-1454      AC H9TEX4.1
#=GS B6VDX8_THCOV/1151-1192      AC B6VDX8.1
#=GS H9BR00_9NIDO/1164-1206      AC H9BR00.1
#=GS A3EXH4_BCHK9/1235-1275      AC A3EXH4.1
#=GS A0A059VFK8_9ALPC/1347-1386  AC A0A059VFK8.1
#=GS A0A125R5A5_9ALPC/1428-1467  AC A0A125R5A5.1
#=GS A0A0U1UZD0_9ALPC/1303-1343  AC A0A0U1UZD0.1
#=GS Q9J3E7_9BETC/1285-1322      AC Q9J3E7.1
#=GS A0A0U1UZ37_9ALPC/1218-1255  AC A0A0U1UZ37.1
A3EXJ0_BCHK9/1232-1272                 .MLLCMTNCCSCFkG...MC........SCR.HC--YYDEI....EDVYPAVR...........VHNKRT-a.......
A0A1B3Q5W5_9BETC/1250-1290             l-LLCMTNCCSCArG...VC........SCK.SCA--YEEH....EDVYPAVR...........VHGKRT-a.......
A0A023PMV0_9GAMC/1113-1162             .WVFFMTGCCGCC.C...GCfgimplmsKCG.KKSSYYTTF....DNDVVTEQ...........YRPKKS-v.......
SPIKE_CVMA5/1285-1322                  .FICCCTGCGSCC.F...KK........-CG.NCCDEYGGH....QDSI---V...........IHNI---ssh.....
I1VWF5_CVH22/1131-1169                 l-CCCSTGCCG-F.F...SCl.....asSTR.GCCES----....-TKLPYYD...........VEKIHIQ........
A0A0U1WHB7_9ALPC/1339-1376             .WCCLATGCCGCC.-...SC........LVN.SCSDCGGRR....---LQRYE...........IEKVHIQ........
A0A0U1WHD9_9ALPC/1342-1378             .WCCLSTGCCGCC.-...SC........-MA.STLDFRGSR....---LQQYE...........VEKVHIQ........
A0A023Y9K3_MERS/1285-1322              .FLLCCTGCGTNC.M...GK.......lKCN.RCCDKYDDY....D-----VE...........PHKIHVH........
K4JZP8_9ALPC/1315-1351                 .YCCCATGCCG-C.F...SC........-LS.NSCDCRGKN....---LQRYE...........VEKVHIQ........
R9UQ53_MERS/1316-1353                  .FILCCTGCGTNC.M...GK.......lKCN.RCCDRYEEY....D-L----E...........PHKVHVH........
SPIKE_IBVB/1113-1162                   .WVFFMTGCCGCC.C...GCfgimplmsKCG.KKSSYYTTF....DNDVVTEQ...........YRPKKS-v.......
C6GHE6_9ALPC/1433-1472                 .FCCLSTGFCG-C.F...GC........-LG.SCCNSLCSR....RQFESYEP...........IEKVHIH........
SPIKE_BCHK4/1317-1352                  .FLLCCTGCGTSC.L...GK.......mKCK.NCCDSYEEY....D-------...........VEKIHVH........
A0A0U1WHB6_9ALPC/1342-1378             .WCCLSTGCCGCC.-...SC........-MA.STLDFRGSR....---LQQYE...........VEKVHIQ........
B1PHK2_9ALPC/1339-1375                 .WCCLATGCCGCC.-...SC........-MA.STLDFRGSR....---LQQYE...........VEKVHIQ........
SPIKE_BC512/1332-1371                  .FCCISTGCCGCC.-...GC........-CG.SCFSGCCRG....TKLQHYEP...........IEKVHVQ........
A0A088DJY6_9BETC/1281-1316             .MLCCMTSCCSCFkG...LC........ACK.RCCDSFDEP....DE------...........-------pikyhy..
A0A2H4MXZ6_9NIDO/1184-1221             c-LLFMTGCCGCC.-...GC........-CG.GCCGKACSK....P--PDYEE...........LEKLHVA........
SPIKE_CVP67/1313-1348                  .FICCCTGCGTSC.F...KK........-CG.GCCDDYTGH....QEFV----...........-------iktshd..
A0A0S2ZWY7_9GAMC/1149-1198             .WVFFMTGCCGCC.C...GCfgiiplmsKCG.KKSSYYTTF....DNDVVTEQ...........YKPKKS-v.......
A0A0U1WHB3_9ALPC/1338-1375             .WCCLATGCCGCC.-...SCl.....vnSCG.DC---GGKR....---LQRYE...........IEKVHIQ........
A0A172AZS6_9ALPC/1397-1438             .FCCLSTGCCGCCgCl.tSC........-LA.GCCKNSCKR....PS--YYEP...........MEKVHIN........
A0A1L2KGB2_9ALPC/1332-1372             .FCCIATGGCGCCsC...MT.......sSLR.GCCDCGSTK....---LPYYE...........FEKVHVQ........
A0A1X9JJW0_9ALPC/1090-1126             .WCCCATGCCGCC.G...MLg......sACN.GCCTKPQTV....-------E...........FEKVHVQ........
A0A140ESF1_9NIDO/1118-1160             .TIFLCTGCCGGC.F...GC........-CG.GCFGLFSKKk.ryTDDQPTP-...........SFKFKEW........
C0KYU0_9BETC/1337-1374                 .FICCCTGCGSCC.F...RK........-CG.SCCDEYGGH....QDSI----...........-------vihnisah
A0A0U1WHD7_9ALPC/1346-1387             .FCCCSTGCCGIF.-...SCm.....asSCG.ACCDIRGTK....--LQRYEA...........IEKVHVQ........
A0A0U1WJW4_9ALPC/1092-1132             .WCCLATGCCGMC.-...GCl.....aaTCA.SCCDCKGTK....---LQSYE...........IEKIHIQ........
SPIKE_BCHK5/1317-1352                  .FILCCTGCGTSC.L...GK.......lKCN.RCCDSYDEY....E-------...........VEKIHVH........
U5LNM4_9BETC/1294-1330                 .FILCCTGCGTSC.L...GK.......iNCT.RCCDKYDDF....DM------...........PEKIHIH........
S5YNL4_9ALPC/1325-1364                 .FCCIATGCCGCC.-...GC........-CA.SCLTGCCKG....PRLQPYEA...........IEKVHVQ........
E3W5J0_9ALPC/1426-1465                 .FCCLSTGCCG-C.F...GC........-LG.SCCNSLCSR....RQFESYEP...........IEKVHIH........
SPIKE_BCHK9/1232-1274                  .MLMCMTNCCSCFkG...MC........DCR.RCCGSYDSY....DDVYPAVR...........VNKKRT-v.......
SPIKE_CVH22/1135-1173                  l-CCCSTGCCG-F.F...SCf.....asSIR.GCCES----....-TKLPYYD...........VEKIHIQ........
A0A0F6YS09_9GAMC/1142-1191             .WIFFMTGCCGCC.C...GCfgiiplmyKCS.KKSSYYTTF....DDDVVGEQ...........IRPKK--fv......
A0A1L7HJ82_9ALPC/1098-1134             .WCCCATGCCGCC.G...LCg......aACN.GCCTKP---....---QPIE-...........FEKVHVQ........
H9BR17_9NIDO/1199-1254                 .TIFLCTGCCGGC.F...GC........-CG.GCFGLFSKKidpmRQYMNRYEtptsksddaipIIYKKNW........
H9BR25_9NIDO/1162-1212                 .TIFLCTGCCGGC.F...GC........-FG.GCCGLFSRVk..hHEFSHLPVeeqd...gsipITYKKV-n.......
A3EXI2_BCHK9/1229-1269                 .MLLCMTNCCSCFkG...MC........SCK.QCH--YDEV....DDVYPAVR...........VYNKRT-a.......
H9BR35_9NIDO/1170-1214                 .TIFLCTGCCGGC.F...GC........-FG.GCCGLFRKHkfyeEDTKQTPV...........FFKVKEW........
D9J204_9ALPC/1387-1429                 .FCCLSTGCCGCC.-...GCl......sSCAaGCCKYGCSR....-DLSRYEP...........IEKVHVN........
SPIKE_BC133/1315-1350                  .FLLCCTGCGTSC.L...GK.......mKCK.NCCDSYEEY....D-------...........VEKIHVH........
A0A0K2RVL1_9BETC/1327-1362             .FICCCTGCGTSC.F...KK........-CG.GCCDDYTGH....QEL-----...........-------viktshd.
I7B987_9BETC/1196-1233                 .FICCCTGCGSCC.F...RK........-CG.SCCDEYGGH....QDSI----...........-------vihnisah
B7U2M2_9BETC/1327-1362                 .FICCCTGCGTSC.F...KK........-CG.GCCDDYTGH....QEL-----...........-------viktshd.
A0A240FW18_9ALPC/1101-1134             .WIFMCTGCCGLCdC...IR........--R.SCCDS----....---NTYEP...........IEKIHIQ........
A0A060A825_9NIDO/1118-1160             .TIFLCTGCCGGC.F...GC........-CG.GCFGLFSKKk.ryTDDQPTP-...........SFKFKEW........
SPIKE_CVPPU/1408-1447                  .FCCCSTGCCG-C.I...GC........-LG.SCCHSICSR....RQFENYEP...........IEKVHVH........
SPIKE_FIPV/1413-1452                   .FCCFSTGCCG-C.I...GC........-LG.SCCHSICSR....RQFENYEP...........IEKVHVH........
B7U2N3_9BETC/1327-1362                 .FICCCTGCGTSC.F...KK........-CG.GCCDDYTGH....QEL-----...........-------viktshd.
A0A0U1WJW2_9ALPC/1333-1370             .YCCIATGCCG-C.L...SC........ICS.SCADCRGKR....---LQRYE...........VEKIHIQ........
A0A4D6FWE9_9GAMC/1135-1184             .WIFFMTGCCGGC.C...GCcgliplaqRCS.KKSSYYQTF....DDDVVGER...........IRPKKN-v.......
A8JNZ2_9ALPC/1088-1128                 .WCCLATGCCGMC.-...GCl.....aaTCA.SCCDCRGTK....---LQSYE...........IEKIHIQ........
B1PHI8_9ALPC/1338-1384                 .WCCLATGCCGCYnCllkSC.......sDCG.GNAYNVTKL....RKSTFSNV...........GWSLSV-a.......
H9TEX4_9ALPC/1415-1454                 .FCCCSTGCCG-C.I...GC........-LG.SCCHSICSR....RQFENYEP...........IEKVHVH........
B6VDX8_THCOV/1151-1192                 .TIFLCTGCCGGC.F...GC........-CG.GCFGLFSKR...kFDSDPTPV...........SFKLKEW........
H9BR00_9NIDO/1164-1206                 .TIFLCTGCCGGC.F...GC........-CG.GCFGLFSKKk.ryTDDHPTP-...........SFKFKEW........
A3EXH4_BCHK9/1235-1275                 .MLLCMTNCCSCFkG...MC........ACK.PCH--YDEV....EDVYPAVR...........VYNKRT-a.......
A0A059VFK8_9ALPC/1347-1386             .FCCISTGCCGCC.-...GC........-CC.ACFSGCCRG....PRLQPYEV...........FEKVHVQ........
A0A125R5A5_9ALPC/1428-1467             .FCCLSTGCCG-C.F...GC........-LG.SCCHSLCSR....RHFENYEP...........IEKVHIH........
A0A0U1UZD0_9ALPC/1303-1343             .WCCIATGCCGCC.-...SCi.....taSCA.GCCDCRGKR....---LQRYE...........VEKIHIQ........
Q9J3E7_9BETC/1285-1322                 .FICCCTGCGSCC.F...KK........-CG.NCCDEYGGH....QDSI---V...........IHNI---ssh.....
A0A0U1UZ37_9ALPC/1218-1255             .YCCIATGCCG-C.L...SC........IFS.SCADCRGRR....---LQRYE...........VEKIHIQ........
#=GC seq_cons                          .ahChsTGCCGsC.h...uC.........Cu.uCCsphspt....pp...h.............lcKl+l.........
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