GenomeNet

Database: Pfam
Entry: ComR_TPR
LinkDB: ComR_TPR
Original site: ComR_TPR 
#=GF ID   ComR_TPR
#=GF AC   PF18710.3
#=GF DE   ComR tetratricopeptide
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08223
#=GF GA   26.50 26.50;
#=GF TC   26.50 42.80;
#=GF NC   26.40 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Repeat
#=GF CL   CL0020
#=GF RN   [1]
#=GF RM   27907189
#=GF RT   Structural Insights into Streptococcal Competence Regulation by
#=GF RT   the Cell-to-Cell  Communication System ComRS.
#=GF RA   Talagas A, Fontaine L, Ledesma-Garcia L, Mignolet J, Li de la
#=GF RA   Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna
#=GF RA   G, Hols P, Nessler S;
#=GF RL   PLoS Pathog. 2016;12:e1005980.
#=GF RN   [2]
#=GF RM   27907154
#=GF RT   Pheromone Recognition and Selectivity by ComR Proteins among
#=GF RT   Streptococcus Species.
#=GF RA   Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna
#=GF RA   G;
#=GF RL   PLoS Pathog. 2016;12:e1005979.
#=GF DR   INTERPRO; IPR040799;
#=GF DR   SO; 0001068; polypeptide_repeat;
#=GF CC   In Gram-positive bacteria, cell-to-cell communication mainly
#=GF CC   relies on extracellular signaling peptides. ComR is a member of
#=GF CC   the RNPP family, which positively controls competence for
#=GF CC   natural DNA transformation in streptococci. It is directly
#=GF CC   activated by the binding of its associated pheromone XIP [1].
#=GF CC   The crystal structure analysis of ComR shows that it contains an
#=GF CC   N-terminal helix-turn-helix (HTH), DNA binding domain (DBD) and
#=GF CC   a C-terminal tetratricopeptide repeat (TPR) domain. The TPR
#=GF CC   domain is composed of 11 alpha-helices forming 5 TPR motifs
#=GF CC   followed by an additional C-terminal alpha-helix 16 called CAP.
#=GF CC   The pheromone XIP binding site is found in the TPR region.
#=GF CC   Biochemical and mutational analysis indicate that, if the
#=GF CC   interacting XIP is accepted it can then trigger the
#=GF CC   conformational change of the TPR domain to open the DBD-TPR
#=GF CC   interface to allow dimer formation that is required to bind DNA
#=GF CC   [2].
#=GF SQ   64
#=GS A0A139NHK9_9STRE/15-234  AC A0A139NHK9.1
#=GS A8AZ57_STRGC/75-293      AC A8AZ57.1
#=GS A0A2L0D697_9STRE/78-290  AC A0A2L0D697.1
#=GS E1M6K7_9STRE/1-73        AC E1M6K7.1
#=GS A0A242K5G9_9ENTE/1-126   AC A0A242K5G9.1
#=GS M4YVN8_STREQ/73-296      AC M4YVN8.1
#=GS A0A380K4I3_9STRE/72-294  AC A0A380K4I3.1
#=GS Q8CY78_STRR6/98-165      AC Q8CY78.1
#=GS K1LYB9_9LACT/75-296      AC K1LYB9.1
#=GS A0A3P1VDL4_9STRE/75-293  AC A0A3P1VDL4.1
#=GS A0A242K4G0_9ENTE/75-293  AC A0A242K4G0.1
#=GS A0A5C5TCY1_9STRE/75-293  AC A0A5C5TCY1.1
#=GS A0A380K3S0_9STRE/1-164   AC A0A380K3S0.1
#=GS A0A380K4J4_9STRE/76-120  AC A0A380K4J4.1
#=GS A0A2I8AN88_9STRE/72-295  AC A0A2I8AN88.1
#=GS Q8DWI6_STRMU/73-296      AC Q8DWI6.1
#=GS A0A172Q9J0_9STRE/77-295  AC A0A172Q9J0.1
#=GS S4DAL8_ENTFL/73-292      AC S4DAL8.1
#=GS A0A139NAG1_9STRE/71-295  AC A0A139NAG1.1
#=GS F9Q0K8_STROR/1-76        AC F9Q0K8.1
#=GS A0A3P1V774_9STRE/74-297  AC A0A3P1V774.1
#=GS A0A139NGW5_9STRE/72-296  AC A0A139NGW5.1
#=GS F5X439_STRPX/73-294      AC F5X439.1
#=GS A0A1T4MJM7_9ENTE/73-293  AC A0A1T4MJM7.1
#=GS A8AZ18_STRGC/75-293      AC A8AZ18.1
#=GS G5KFI5_9STRE/73-240      AC G5KFI5.1
#=GS Q8E2E0_STRA5/73-296      AC Q8E2E0.1
#=GS A0A380K385_9STRE/73-294  AC A0A380K385.1
#=GS A0A0F3H686_STRPA/76-290  AC A0A0F3H686.1
#=GS Q8DVT6_STRMU/75-294      AC Q8DVT6.1
#=GS F9Q2E1_STROR/12-104      AC F9Q2E1.1
#=GS A8AZW8_STRGC/82-296      AC A8AZW8.1
#=GS B9DST9_STRU0/72-295      AC B9DST9.1
#=GS Q5M612_STRT2/75-294      AC Q5M612.1
#=GS A0A3L9DNT9_9STRE/73-296  AC A0A3L9DNT9.1
#=GS A0A0E4CTV3_9STRE/73-296  AC A0A0E4CTV3.1
#=GS E1M6K6_9STRE/71-193      AC E1M6K6.1
#=GS G5K5D9_9STRE/73-296      AC G5K5D9.1
#=GS A0A172Q9H5_9STRE/75-281  AC A0A172Q9H5.1
#=GS A0A1L8QQ60_9ENTE/1-211   AC A0A1L8QQ60.1
#=GS A0A4R0QFG6_9STRE/1-207   AC A0A4R0QFG6.1
#=GS A0A242K4M9_9ENTE/75-165  AC A0A242K4M9.1
#=GS F9Q2E0_STROR/1-59        AC F9Q2E0.1
#=GS A0A242K4G7_9ENTE/75-293  AC A0A242K4G7.1
#=GS F9Q0K9_STROR/75-192      AC F9Q0K9.1
#=GS G5JQ00_STRCG/75-294      AC G5JQ00.1
#=GS A0A2L0D265_9STRE/72-295  AC A0A2L0D265.1
#=GS A0A242K672_9ENTE/1-112   AC A0A242K672.1
#=GS A0A172QA32_9STRE/72-295  AC A0A172QA32.1
#=GS A0A1Q8E6R5_9STRE/73-296  AC A0A1Q8E6R5.1
#=GS A4VSD6_STRSY/78-299      AC A4VSD6.1
#=GS A4VSD6_STRSY/78-299      DR PDB; 5FD4 B; 78-299;
#=GS A4VSD6_STRSY/78-299      DR PDB; 5FD4 A; 78-299;
#=GS Q8DND0_STRR6/70-291      AC Q8DND0.1
#=GS F9PYQ6_9STRE/1-142       AC F9PYQ6.1
#=GS A0A1E5GSY1_9ENTE/63-280  AC A0A1E5GSY1.1
#=GS A0A1Q8EB20_9STRE/75-295  AC A0A1Q8EB20.1
#=GS G5KFI4_9STRE/1-49        AC G5KFI4.1
#=GS A0A1G6BIT0_9STRE/73-296  AC A0A1G6BIT0.1
#=GS G6ENH8_STRTR/75-294      AC G6ENH8.1
#=GS A0A1Q8EAZ8_9STRE/74-280  AC A0A1Q8EAZ8.1
#=GS A0A172Q9D4_9STRE/76-290  AC A0A172Q9D4.1
#=GS A0A380K563_9STRE/74-293  AC A0A380K563.1
#=GS A0A139NGV0_9STRE/15-234  AC A0A139NGV0.1
#=GS A0A139NN13_9STRE/1-218   AC A0A139NN13.1
#=GS A0A139NF75_9STRE/74-297  AC A0A139NF75.1
A0A139NHK9_9STRE/15-234             ........................PDSYYEKKNRLIK.FP.TYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDIFESVMNFSLLEKGPKTEEIFEDVFLQAQKKKKLSTNDLLVIHYYFL.....--ENHDKKYLDKKILEMLCR...KLLNQEISADETHNITLIVVLMSCA.AVYLMLEEFKTILPIANRLLQFVDEAQLQTYKPGALALKAKYYSRYLGDSERANRYYDKALSFARLLNDDALVRGIKQEK....................
A8AZ57_STRGC/75-293                 ........................PSGYLELKYRLEK.LY.HYGDGERLQQREELIEEIYRKYFDQLPEEEQLYLQIKQAKNDMVLTENIAYDQGLIDEYLDQALAKEKLTEMDLEIIDLRLL.....---ALGLKDFDKKEFTCLLN...KLLVAVADYPTNGLEKIQTRIIFAA.GVLSHYQEYDRLPEILRVLEELMLRRNDFQDRVFSYALQWKIALFLENNLEKAEDNYQKVKLMLELLPEDVLKENMRLDW....................
A0A2L0D697_9STRE/78-290             ........................PQSYVSLKRRIVQ.FK.SYEDPERLNYLDGLMDEL-QTYYDSVPEEEQMAIEVLQADLDVFVTHKTAFAEQLIEEYFEQVLLKKAYNWNDYLLISLYLF.....---LCAVGIEDSRYFDYFIP...SIFSKGDLSDPDIAYQMEEVVLAVL.AQEN----VAYYPDCIDTLDRVIKVTKHYQNKPILEMFKAKLAL-FQGDIEQMESSYQTAFLIAESLDEPILLNRLKME-y...................
E1M6K7_9STRE/1-73                   .....................mgl-------------.--.----------------------------------------------------------------------------------.....--------------------...-------------------------.--------FHYFKRAIEALNKIGQKTRDFQKQPIVLMLEWKYYI--QTDYDTAKKKYEEAKMMARMFGNEQLIVSLDNEW....................
A0A242K5G9_9ENTE/1-126              ........................-------------.--.--------------------------------------------------------------------------MIIELYFH.....---CIHFKDYDEQLFMTLSD...KVIEQVDYSVDVELFLLIKVLLVAI.SVFIEYDNYDRLIGAVKVANLIMQTNQDFQKKPAVDVFEGKYWLFSQGDVNRAEQKYLD---------------------gaqsvsythldvykrql...
M4YVN8_STREQ/73-296                 ........................PKRYKELKYLILR.TP.TYMDDRKLQVRESQFDEIFENYYDQLPEEEQLIIECLQATLDTLLSENINFGVELLQEYFKQTKVKQRFKQNDLILIELYLAy...lDIEGMYGEYSDKVFYDSLLD...NLLKQFDDFELDELFIVNKIIIDIS.SLSIKTNKLDNLEKTIAISQKIMAKIQDWNRMPILKLIEWKYFLIKQKNRKQAEESYTKACLFAQITGDKYLEEQLIKEW....................
A0A380K4I3_9STRE/72-294             ........................PKRYNELKYLILR.IP.TYSDKERLKEREQQFEEIFEDYYDNLPEEEQLIIDGLQSKFEVYQSGNIHFGTDMIAEYFHQVKKKKSYTLNDLAIIDLYLLi...aAISQFDEQHFQKEDFKIICD...TLLIQGEELAVEDRFLLNNLLLNCV.NIALNLKLAANIQPMLELSHKTMVLIQDFQKMPIYNMYRWKYAL-LQDNQTEAEDYYNQSVMFSKMLNDEHLIQQLDDEW....................
Q8CY78_STRR6/98-165                 ........................-KEYLELKYFLMR.TP.TYEDETIAQKKESVFDKIFEEYYDRLPEEERFII------------------------------------------------.....--------------------...-------------------------.--------------------------------------------------------------------------------pnysylalanytvqklpekl
K1LYB9_9LACT/75-296                 ........................PFEYYQIKDRLMN.FA.SYGLKDKIQEKDDLYEIVFQKYYDYLPEEEQIAIDIMHATSDVVNEHIDLYGQAIIDDYFDQVKLKSSYTLNDLLIIRLYLS.....QVDFTNEQYFDDNLIDTMLS...KVLNQVDFIHYNMVNFGISFYIDSI.TTLFHYKNFNRIEEILTCLDTLIHIDKKAEDLIICTMLKAKWYLYAKNSIPMTKYFYQQAIDYANLFNEVFLADKLTDE-l...................
A0A3P1VDL4_9STRE/75-293             ........................PQRYLDLRYKMQR.LP.HYGNPERIMEREAILDEIYESFFDNLPEEEQLAVQIEHALLDIAATRRPEFDQGLVDEYLERSLAKSQLDMNDMNILFLRQ-.....--LILAFNGFDKEEFVNLLS...RIIHQRTNTTVEGLRLIQNVVISSI.GMLCHFEEYDMLYQLHQVLEELMELIKDYSDKAFVYMTRWKINLYLEHNLEAAKENYSSARQLAQLLSEELLFTNIRNEW....................
A0A242K4G0_9ENTE/75-293             ........................PKGYLQLKRRLYK.FY.TYKEQERKAKKNQLFKEIYETYYDDLPEEEQLSIDVQSATNVLAMTDNVEFGEGILGDYFSQVMQRQEFSVNDLLIIELYLF.....---YIHLREYDEVVFLSLFN...KLVKQIDCSLDVDQFLLIRVLIVSI.SVFIEYGNYDKIIDAVTAADRVMKSNQDFQKKPILDMYEGKYYLFSQKDSTSAKQKFEEGAKLAELQGDSVISQKILKEW....................
A0A5C5TCY1_9STRE/75-293             ........................PESYFEKKYLLFK.SS.SYGNTERIAEKHRIIEEIYQEYFDLLPDEELLTLDLIERLLDWRLHSEGERADSLFADYFEQVLIKDVYVLNDLLLLQYYAV.....---QCQDVTYESEKFGICFE...KVRKQAIQGNEFYNVALLGVLSAFA.GSYLVSQDYEKMLQTVERMDEIIQQTLQQVYRPVTLCFRAKYAVYQSRDKQKAQQAYDMAILLAKDIGDDILWTNLTKEK....................
A0A380K3S0_9STRE/1-164              ........................-------------.--.------------------------------------MQAQLDVFTSRDYQYGLTLLEEYFQQILKKSHYSYNDLLIINLYFF.....---CCALGLEDKSHMEQLAS...RVIEDIDYSDLDRVYATERILVTLL.----INAEPEDYLTYTSVLRDIIERTNNFQHKPAVYAFEAKYYLLVKKDKAKAKALYDKAILFANMLNDEALAEEFIRE-s...................
A0A380K4J4_9STRE/76-120             ........................PKRYLELKNRLTK.TH.TYGDPKRIKELEGFLDEIYEHYYDSLPEEE----------------------------------------------------.....--------------------...-------------------------.--------------------------------------------------------------------------------....................
A0A2I8AN88_9STRE/72-295             ........................PHDYLALKYQIIR.TP.LYMNDQVMAIREGQFDAIFEKYYDYLPDEEKLIIDFLQSKFDVYQSGDANFGRPLLQDYIRQISKKKRYQINDIFLIDLYLTc...aIVSSFKAEFFDLDLYRRFLS...KLLLMEKTLALSDLFLLNNVLLTCI.DVGIRIGHFEVIQPALKASHRIMYKVQDFQRLPIYCMHAWKNALFYTKSVKRGEDYFHQAQLFAKLIGDKNLEGKLAREW....................
Q8DWI6_STRMU/73-296                 ........................PSRYKELKYLLLR.TP.TYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVNDLILIDLYFSc...lTVSGLDSAIFDSRKYNQLLE...TLLKQVDCLPLEDLFVLNNVLLNNF.GLLLELKKYDFVKQLIAVSNKIMDRTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEW....................
A0A172Q9J0_9STRE/77-295             ........................PDSYFRMKYRLFK.IP.SYSDPQRLDEKIELIETIYDHYFSLLPEEELFTLDLLDNIFDYLRKGQRPAAEDSFAEAFKELLLKPRYSLNDLLLAKFYLI.....---QHHSGAYNKALVQKMET...RALKQEISGDDYYNLELINFFSDLS.ALYTSHAEYPKLDVPVKRMHDLIRETRQDSMIPLTLMFEAKYYIYVKQCRNKAEELYNAAVWLAESFDDVLLKTKLIHE-r...................
S4DAL8_ENTFL/73-292                 ........................PRRYLELKDLLFK.SPaTHENKERASKKEEYFDEIYENYFYLLSKEEQLTIELKQIRLDVHMTKNINYCKPILEEYLEEVRDKEYLSLNDIMVIDLYFD.....---YVYEIGYQEKEFNFFVD...KLINFIPYAVDLELIVLDSAFTSAC.GVDNKYENYHRFIKYVEAGRKIMEKNFDYSSIPIWMVIEGKYYLFHEKNKQKAITLYEQAIKQAKFVNDIYLSEFLAEE-l...................
A0A139NAG1_9STRE/71-295             ........................PKRYQELKYFLLH.HP.DYGDKELQEQKEEYFDEIFECFYDKLPRDEQVMIDCLQAIDQVRATDNEQYGQGIIEDYIETLKNQSSFSANDFLKLRLYFLc...mGAEYFKQGTLSKKEQADIKRlfeMVCNQVEQVETSELFLVRDTLFASL.GCCETMGALELFEIAIEKLKWITEKTRDFQKTPIIFMVEWKYYI--QTDFNLAYQRYQEAIMFAKLFGNEQLIQSLDGEW....................
F9Q0K8_STROR/1-76                   .......................m-------------.--.----------------------------------------------------------------------------------.....--------------------...-------------------------.-----EKSYSTFEPYVKAMNRLMILSQDFQKKPIVDMLEAMCTLFHKRDKEKAIHLYDRAIICAQAFEDQVLEARISGEK....................
A0A3P1V774_9STRE/74-297             ........................PRRYKELKYQILR.AP.TYLDEVRLQEREAQFDEIFTDYYDQLPEEECLMVDCIQATMDVALSQNIDFGIGIIQDYFEQVKRKKHLLENDLILLELYFIc...lIISNFDAKIYNSQNFDNLVE...NLLEQEKYGDIDNLFLVNKALIKAF.GASVRLKKYKKLEEIAVTCRRIMTTTGDFQKMPILNLIEWKYYLYSLNDLPSAEACFENAIKFSQIISDDYLEENLNSEW....................
A0A139NGW5_9STRE/72-296             ........................PQEYLSLKYDILN.TQ.VYRHPDLMTQVLKQISDVHERFYADLPQEEAYIFGLLEKMLRAYNLEEDQMPITEIKEHLRPLLNHLYFDLNTLIMIRYVLNre.isYDEKYKKSLFGASYIAMVQE...ELVNLTTTVRREDWFICRDNLITAL.TLSLNHADHEKCFLLLKVLKENMARFQDVQKKMIVMMLEWKIFL-LNNQLDEAQETYDKTKAFVQIIGDKHVLMKIMEEW....................
F5X439_STRPX/73-294                 .......................t--RYKELKYLLLR.TP.TYGDEERLKRQTSYFDEISEKYYEVIPEEERLIIDCLQSKLDVHFSDDVNFGEGILNDYFDQVIRKKNFQINDLVLIDLYFAc...lASAKSFVGIYSLDLYDKLME...CLLDQENLSPETS-LILNNVLLNNV.DLVLRFHRESFMKRIIIKSDTIMTSVHDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLENKLIEEW....................
A0A1T4MJM7_9ENTE/73-293             ........................PKRYLELKNLLFRgIK.VYQNEERAETVDEQFDEIYNNYFEDLPRYEQDTIELKQILHDMTLTKTAGSAEEIIAESFDRVYKKDDLDLNDFLIIKLYFN.....--LSILKNEVDTEEVKTLSQ...KVIEKIESAIDLELLVIGSILTSIA.IILIEKKNYEELLKIIEIGEKLRKKTLDFRSKPVFCMLKGKCILFHQKDPELAKQHYQEAITSAEMLEDSFLSEKIKEE-l...................
A8AZ18_STRGC/75-293                 ........................PPEYIDLKYQLQT.LY.HYGDPERLRLLEKIIDEIYENYFENLPEEEQLSIQIAQATVDMVSAKDPSFDQGLLDEYLEQAMKKKELSFNDVEIIQLRLL.....---SLALGDFNQEEFVDLLG...KVILAADYFPLSDLEKVQNTIVSAA.GVLAHYGIYDILPDIVNVLNDIMTKRRDFQDNIFVHALNWKVALFVEDNLEKAKNDYQKVCMMADLLSEDLVKRNMQEEW....................
G5KFI5_9STRE/73-240                 ........................PKRYKELKYLILR.TP.VFTDVSKINLREQQLDEIYEIYYDELPEIEKLAIDCIQATLDTSLTKDVNFGIGILNDYLIQTKKKKKYQINDLILINLYLAc...lDITKKKGNLYDSHFYKTIFE...IIQQNVQNYHIEEKFIVQQILIQYF.LLSLYYEEFDYLCDIVKLTKQIL---------------------------------------------------------d...................
Q8E2E0_STRA5/73-296                 ........................PKRYKELKYLILR.IP.TYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLNDLIIIDLFLTc...aVVSKFNNRAFTKEVFQTICK...TLISQNHKLTAEDLFWFNHVLLNCV.FVGLCLNSEECLAEMLEVSRQTMVSTHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEW....................
A0A380K385_9STRE/73-294             .......................a--DYLELKQKLLR.IP.TYGDQARLKEREQYFTSIYERFYDQLPEDEQLIIDCLQSKLDVHFSDNDSFGLGILQDYFEQTFKKSTYTVNDFVFFDLYLVc...fAYKKNQEHFYEEEQYDLVMA...KLLNSNPPLAEE-KFQLNNVLLNNI.KLAFGLEKWDIIENIVSKSNQLMTEIHDFQKRPILSLIEWKYQLYAKQDTALATQSYQNAILFAKLIGDDYLEKQLSQEW....................
A0A0F3H686_STRPA/76-290             ........................PKDYLRLKKELVD.SP.TYADRERIERKLAILEEIGECYYDRLPEDEQLLIDVIQARLDIYNSSDVRYGLALLEEYFQQILKKTIYTVNDLLIIELYFF.....---CCAVGLEDKRYFQELAD...KVMLDIDYGDKEYLTQLEKILLVLL.AQLE----EKYTLKYIQTFEDVIDKTRHVYYKPIIYMFKAKYMLHVEKNKEKSEEFYGKAITFAELLDDEVLVQRLLEEK....................
Q8DVT6_STRMU/75-294                 ........................PDDYWELKGQIVK.FP.TYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAFNDYLYMSYFLQ.....--KCGKTADYDQTTFKLLEQ...KLLKQELTVDELYNIELLIAVMEAS.GVYALHNDYQNLLPLMKKAQRIIDKAQLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEM....................
F9Q2E1_STROR/12-104                 itklqylskrlevpidtflenkel-------------.--.------------------------ALPKEELLSLDLIERILDLIRTGTGSFAEDIFDDYFKQVTLKQVYTFNDLLLIDYFAM.....--------------------...-------------------------.--------------------------------------------------------------------------------qcqdliyrreh.........
A8AZW8_STRGC/82-296                 ........................PKRYLELKNKLIR.SH.TYGDEERISILEEMFDEIYENFYEHLPEEEQLLVEVLQVQLDVFSSRDITYGLSLLEEYFQQILKKKKYSYNDLLIINLYFL.....---CCATGLEDKTYFEELSK...KVLLYIDYSDNDRIYILERILIGIL.IQVK----TEDYLIYTKVLREITESTNNFQHKPAIYAFEAKYYLKVEESYEKAEQSYNKAIEFANLLNDQVLASNLLKEK....................
B9DST9_STRU0/72-295                 ........................PKRYQELKYLILR.HP.TYMNTDSIEERESQFDIIFEDYYADLPEEEQVLIDRLRSRFEVYQSGNSVYGQDLLLEYIDQIKKKKTYDLNDIFFIDLYLTc...gYVSSFKETLFDKGIFECFTS...KLILLEEKLDFKDLFLLNNVLMTAI.AVGLTLEEYVKIRTLLNVCRRIMTITQDFQRMPIYYMYEWRYTLFHEKDFRKAPYYYQQSLLFARTHGDEYLKTMIVNAW....................
Q5M612_STRT2/75-294                 ........................PDEYYEMKNRLIK.FP.TYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF.....--HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLMAIA.ALKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk..................
A0A3L9DNT9_9STRE/73-296             ........................PKRYKELKYLILR.TP.TYLDEERLKVREEQFDEIFEEYYDKLPEAEQVLVDIVQARFEVFNSGNKEFGSSILEDYFEQVKKKKFYGINDMALIDLYLIc...vLVENFDVEFYDEVTYNQFIQ...NLRNQGSYLNVEDLFFLNKIYLIIC.SVLVKKGDYAQLEDYLDELYHLILKSQDFQRMPLYYMYRWKYSLSYLDDKNSAEEFYAHAILFAEMTSDLYLVKKLKDEW....................
A0A0E4CTV3_9STRE/73-296             ........................PEDYLNLKYDILR.TP.TYGENKKIDWRDQILTEIYDNYYDDLPEEEQLAVDTIQSFFDVHDTSEAIYGKEILEEYFFQISHKDAYSINELLMIRLFLEh...aRMTELSKFPKENAVFQHLLK...TLPCQVNVVRPKDLFILRDVLFVMV.GVAGSKEQNDCIPAFIQTIEQIMNRTQDYQKLPILKMISWKYKLYVDKNKKDAEQLYEAAKLSAGMIGDPNLLEKIENEW....................
E1M6K6_9STRE/71-193                 ........................PKRYQELKYFLLH.HP.DYGDKELQEQKEEYFDEIFECFYDDLPRDEKVLVDCLQAIDEVRATGNSLYGTSLLENGLHNLLFRDVYKAEELLRLRLYFAc...nLMDGLKAGEIKESEHETILY...-------------------------.--------------------------------------------------------------------------------fmin................
G5K5D9_9STRE/73-296                 ........................PKRFKELKYLILR.TP.TYMDGDKLKTREAQFDEIFEDYYDQLPEVEQLVIDCLQSKFDVYQSGDINFGSPLIQEYINQISKNTKYQLNDLLIIDLYLTc...aVVSNFSKYHFDLSLYQEFVN...TILKSEEELLLEDLFMLNNILHTCL.DVSIRLKDYLKVEQMLLLSQKIMSRIQDFQKIPMYCMYYWKYALYHLNDFAKAKHFYEQSVMFTSLTNDNYLVKKLEKEW....................
A0A172Q9H5_9STRE/75-281             ........................PQAYFEQKYKLIK.FP.SYGDAERLAPKK------------QLPEEELFTLDLLEKSFDRMTVGESGSAEQIYEDFFKQLLSKETYSLNDILLVKYYFI.....---QCQDSVFDRKTFQHLVA...RLLKQEITGDEYYNVELLGALSALA.GVYVVSADYSDMKPTLDKMDDVVNQTMQHVYKPILLMLEAKYYLYQGHNFQKAKSCYDLALTLAENFGDTVLINNLKKE-r...................
A0A1L8QQ60_9ENTE/1-211              ........................-----------MK.QT.MYKDSIRAEKVNLLFDQIYDNFYDQINEEEQLTIDILRATTDIVVFNNVQFESGLLKEYFPQTLLKKELCELDFLLIYLYFF.....YIFGKDKAYKNRNTTKQAIN...KLVKNSDYSNDSNAYLAIKIHIIAL.NFLSELKDYDTYKQLLDISKTISEENQEFQKKPILQMMEAKYLLFHVSDTEKAKVMYRVAAKTAMLLGDNIAHDQIL---lem.................
A0A4R0QFG6_9STRE/1-207              ........................-------------.--.--MDQDRIKEREEHFDEIFSEYYDELPEEEQLAIDALQSSFEVYHTGQVDFGVDLIPEYFEQLKKKKRYRMNDLILIDLYLTa...aAISYFDSSIFQKSDFLHFCR...NLLQQRKYLLSEELFFLNRLILTAV.AMRIYLKDADLVLELLNESNAIMEVTEDFQKKSIYCLLQCEYAIFYKKDKELAKHYYEEALLFAKLFNDKKLQEQLQVEW....................
A0A242K4M9_9ENTE/75-165             ........................PKRYLQLKQRLYK.LY.TYKEEERIAKKEQTFDEIYENYYDQLPEEEQLSIDVQQASMDVHLAENADFGDGILHDYLYQILQKKEYSINDLLI------.....--------------------...-------------------------.--------------------------------------------------------------------------------....................
F9Q2E0_STROR/1-59                   ........................-------------.--.----------------------------------------------------------------------------------.....--------------------...-------------------------.------------------MNEILSVTTLQVYKPGISVFEAKCYLYFENDKNKAKELYHSATILAEQFDDKVLEN------eki.................
A0A242K4G7_9ENTE/75-293             ........................PQRYQQLKYKLYR.LV.TYNEEDRLLKRKRYFNEIYEHYYADLPEEEQLAIDGQQATMEVHLKEETDFGEGILHDYFSQITNKTEYTNNDLLIIELYFH.....---CIHFKNYDDTLFMTLLD...HVIDQIAHSIDTTLLLLHKLLLLAA.SVFMEYDNYDRLKSVVNASNDIMKKSQDFQKKPVINLLEGKYWLFAQKDKIKAQQKYEDGAQCAQLFGDFVLSDKIMAEW....................
F9Q0K9_STROR/75-192                 ........................PSEYLILKDKLIK.FQ.TYGDDDRIQVKEELFDRVYEHYYDSLPEDEQIAVSALQASFDVFVSEDAGFGDTLLDEHFEQVKIRKNYSVNDLLLIKLYFG.....-SCLARPTKYNHELFWMLS-...-------------------------.--------------------------------------------------------------------------------knf.................
G5JQ00_STRCG/75-294                 ........................PADYFELKHRLVK.FP.TYGDPERVEQKQAMIEEAYEKYFTVLPEEELLFLDLSEKILNWSQTQKIVDIKGIYEDAFEQIQRKKVYTMNDLMVVGYYLF.....--GIHNKKYYDKKLFNKLKN...RLLEQEPSTNELYNIDLLSILISVL.GVYVQHGNYQATLPVIKKIYQLIEKTQQPIYRPSVMMVEAKYYLNIEEDKERATQLYDQAINFATLLGDEVLADGLRDEK....................
A0A2L0D265_9STRE/72-295             ........................PFRYKELKYLIMR.TP.TYRQEQQIKQITQYFDEIYLDFFEKLPEDEKIAIEVLQTSMDIHLDEDVNFGGDLVRESFQQIQLKKRYELNDLLIIRLYFFy...iYFANFQDTLFDLSIVKKLCG...YLKKQAQFTHPSDLFLLRDILLQAI.TILIKLEEFQDASDLIEQTRDIISTTQDYQKQPILDMMEWKLILAQHNNRGAAEAKYNEALLFSRIVGNQYLEEQLIIEW....................
A0A242K672_9ENTE/1-112              .......................m-------------.--.----------------------------------------------------------------------------------.....--------------FLTLFS...RVTDQIDYSIDIEQFLLIKALIVSI.SVFLEFGNYDKIIDAVTAANKIMNVNQDFQKKPIIDMHEGKYYLFSQKDVPTAKQKFEEGAKLAELQGDSVISQKILKEW....................
A0A172QA32_9STRE/72-295             ........................PARYEELKYLIMR.TP.IYADTNRVELVETYFDEVYEQYYDNLPEEEQLAIDILQSSLDVQITDNIEFGSILLQDYFEQVKAKRIYSINDLLIVGLYFYq...iSSESIYSDDISSETLDMLAG...RLILQTHYIVPSYLFLLRDVLLQCG.GMLLLTHSYQHLPAIVQELNTIINKTQDYQKKPLVDMLEWKYYLYVKQNFSRAQQKYQQAVQFSAMIDDAVLKENLEKEW....................
A0A1Q8E6R5_9STRE/73-296             ........................PDQYVKLKYDILR.TP.TYNRADLIDKRNGKLKQIYDRFYDQLPDIERVAIDALQSTIDVLETKSDIFGREIVKKHIPRIERKRKYDVNDLLVIHLFMEh...aYLSNLRKKSDSRKMFLKLVA...ELPKQVMLMEPEDLFVLRNVMFATI.RVLGAKEICDPIPALFQGLDQIMQITQDFQKYPIFSMLRWKYELLVHRDVNRASSYCKEAMVFAKLMGNLHLMEQLHAQW....................
A4VSD6_STRSY/78-299                 ........................PERYSKLKFDVLR.TP.TYGNEDLAEKRDAMMTEIYDDYYDELPEEEKIAIDAIQSRIDTLESGTAGFGKEILEDYFEQIFRKRKYELNDLLIVRLHLEy...vRLSSCDSEIF--RQFLKIIE...HLHEQINIINSNDLFVLRDTLLSCV.NILGSKKYYEPIPKIFDSVDKIIQSTQDFQKKPIVSVLKWKYALFVDKDRDEAEKHYLDAVLFAKLIENRELEQKIEEDW....................
#=GR A4VSD6_STRSY/78-299      SS    ........................-HHHHHHHHHHHH.--.-TT-HHHHHHHHHHHHHHHHHTGGGS-HHHHHHHHHHH-----SS--SSSS-HHHHHHHHHHHHH-SS--HHHHHHHHHHHHH...HCCS-TTSHHH--HHHHHHHH...HHHHHTTTS-GGGHHHHHHHHHHHH.HHHHHTT--TTHHHHHHHHHHHHHHHT--TTHHHHHHHHHHHHHHTS--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHH....................
Q8DND0_STRR6/70-291                 ........................PSAYLELKYQILR.EP.IYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY.....QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLISGM.CCLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAKLIGDGFLVKELTEEW....................
F9PYQ6_9STRE/1-142                  ......................ml-------------.--.-----------------------------------------------------------------RTEYSTNDLLLLYLYFL.....--SLAVNAERDEITLKKVCL...NIVSQTNYDDTNYIHLLQRVLIGLV.LYQLDIDYHEFIPEILSILREIMIDIGDTSLKPTVDFIEAKYYLYGEKDKEKALQYYEKAINGAEFLNDMNFKNRVIEEK....................
A0A1E5GSY1_9ENTE/63-280             ........................PERYIRLKMSLFK.RP.PQYNHAMEKIVEDIFEEIYKDYYEVLPEEEQLLVDIAQAQNDVNLSEKIDFGEGILQEYFFQVKNKKEYSENDLLIVHLYFG.....---CCHYKPYDDQEFDTLVE...KCLEQVNYSSELGLIILNRVLGTIA.GLYIISDQYDKVLNVIKISNTIMKMSQDFHRKPIIDMVEGKYWL-HCNDIEKANKKYNDAMVLAQLHGEDLLAERIKMEW....................
A0A1Q8EB20_9STRE/75-295             ........................PQDYLDLKYLALR.LS.AFGQEEKLDEMAACVEEMAERFYDQLPEDERVIIWILRCRIRMCRGIKPATRTQIFDDYLEQVQRRKVYGINDLLLIHVYFL.....-ACQLIEDLLEEPFYRQMVD...CLLEQDQHLKIEEWFILRDVLIACL.TAGLQYGLAYKHREMLALLEQMMELTQDYQKKAVVYLLEWKCAMMFRQDVALARKSYQQALAFSHVLRDTYLRQQLMSEW....................
G5KFI4_9STRE/1-49                   ........................-------------.--.----------------------------------------------------------------------------------.....--------------------...-------------------------.-------------------------------MPIICIMEWKYFLNCLLDFKKAKSCHTKAILFANMMGDDYLEEKINEEW....................
A0A1G6BIT0_9STRE/73-296             ........................PKRYTELKYLILR.TP.TYMDAERLRIREEQFDEIYEKFYEELPEDEQLTITFIQSKFEVYQTGDTEFGTDVIEDYFKQVQKKKLYTLNDIVLIDLFLTc...sIVSNFTSHLFDNAIYELLSS...NLIKQSEYLPIEDLPLLNSVLLVCA.DASVRLEKFNLLSNLLSASHSLMTKIQDFQKMPIYNMLMWEYYLFGENNYVQAENHYNQSILFAKMMNDIHLAEKLEKEW....................
G6ENH8_STRTR/75-294                 ........................PDEYYEMKNRLIK.FP.TYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF.....--HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLMAIA.ALKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk..................
A0A1Q8EAZ8_9STRE/74-280             ........................PKRYLDLKYLVMR.TG.LFGQSTLVAQKEAYLLEMYEEFYDDLPEDEQVAVDVLQSWVDVFVTGQPTFGNRMLEEYFEQVKQRSVYQVNDLLLLELYFY.....-CVYLDNSLFNRRLYRHFVN...GLLAQDQHLPVEQLFLLSTVYVTCV.AVGLNNGYCDGIGQLVKQSKEIMKQIQDFQNLPIVHLQECQILF--LKNRQLAEK-------------------------kveellnsistig.......
A0A172Q9D4_9STRE/76-290             ........................PKRYLELKNRLIK.SH.TYGDKERIAKQEEIFDEIYNNYYDFLPEEEQLLVEALQVQLNVFTSRDIGFALGFLEEYFQQILTKKNYSYNDLLIVYVYFT.....---CCAMGLEDKEYFDELSK...KVLLHVDYSDLEKLYLVERVLLSIL.VQVD----PTEYLIYTKIFREIMKESNHFQHKPVVYVFEAKYYLDIEQNKNKTIESYDKAIMFAKMLNDEVLARNIEIEK....................
A0A380K563_9STRE/74-293             .......................s-KDYLKLKVEFIR.LS.TYDDSDRKAKKEEIIDTIFEKYYDNLPSDEQLTLTILSTEMEMLHSKDTTYGEELFKEVQSKIFNIQRITVNEILWMNFYLV.....-YISGREDLYSKEKINDILA...IIISI-DNDDELFLELEIKLCVTLC.GVMIWSNTLEKFSKLRPTFKRLILKHSDSKSIPIYHMMNGKYAMLVEGKRREALLHYDRALEEARFLEDDILYQRISEEM....................
A0A139NGV0_9STRE/15-234             ........................PDSYYEKKNRLIK.FP.TYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDILESVMNFSLLEKGPKTEEIFEDVFLQAQKKKTFLLNDLLVIHYYFL.....--EIHRNKYIDEKLLGQLER...KLLVQEISSEEVYDILLITTLMDIA.TIHMLKDDYKPILQFVNRVLQIADEAQLHTYKPIATTMKAKYFNHYEHNMEKAEQYYDEAMAFAKLLGDDVLAQGIKQEK....................
A0A139NN13_9STRE/1-218              ........................----------MLR.RP.TYGNEELLEKKDQVFREIYDDYYDNLPVEEQMAIDAYSSGLDILRTEDAVYGNEIIHRHFYEIYEKEFYTINDLIVIRLFIIwldtsHQQQTNDVSKNMVYLENLAE...KLPKQRDNYDLEEVFVLRDLLINLIiQMGRFQLKLEKLPELFDVVEDIMEESHDLQKKPVLLQLKWTYYLKVKDNYEEAYRCYQDALQLTQLLGDAHLKALLES--vw..................
A0A139NF75_9STRE/74-297             ........................PEDYLKLKYQLIR.TT.SYGDKDVLSELDEAVDAIFARYFDDLPEEEQFIIEVLQSKLYTYEMEGERFGKPILEENLSKLRDKKQYTINDLLIVDLYQTh...lDDEDLLSKSFDIDCFNAIVR...TTLDSIEGLGREYLFKARDVLLYVP.YAEFIRKDFRYSKEVLECLNTIMTMTQDYQQKPLVKMMEWQYLLGYKQDVDGAKECYQEAVSLAKLFGNEFLAEKLTEEW....................
#=GC SS_cons                        ........................-HHHHHHHHHHHH.--.-TT-HHHHHHHHHHHHHHHHHTGGGS-HHHHHHHHHHH-----SS--SSSS-HHHHHHHHHHHHH-SS--HHHHHHHHHHHHH...HCCS-TTSHHH--HHHHHHHH...HHHHHTTTS-GGGHHHHHHHHHHHH.HHHHHTT--TTHHHHHHHHHHHHHHHT--TTHHHHHHHHHHHHHHTS--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHH....................
#=GC seq_cons                       ........................PpcYhcLKhhlh+.hs.oYtcpc+lpp+cphh-EIa-paaDpLPE-Eplhl-hlputh-hh.spphtauptllp-ahpQlhpKcpashNDLlllcLYhh........thttt.hspphapplhp...pllpp.p.ht.p.hhhltphLhshh.shhh.htphphh.phlphhpplhppspDapppPll.hhchKYhLhhppshppApphYppAhhhAphhsDphL.ppltpEh....................
//
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