#=GF ID   ComR_TPR
#=GF AC   PF18710.4
#=GF DE   ComR tetratricopeptide
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08223
#=GF GA   26.50 26.50;
#=GF TC   26.50 51.20;
#=GF NC   26.40 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Repeat
#=GF CL   CL0020
#=GF RN   [1]
#=GF RM   27907189
#=GF RT   Structural Insights into Streptococcal Competence Regulation by
#=GF RT   the Cell-to-Cell  Communication System ComRS.
#=GF RA   Talagas A, Fontaine L, Ledesma-Garcia L, Mignolet J, Li de la
#=GF RA   Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna
#=GF RA   G, Hols P, Nessler S;
#=GF RL   PLoS Pathog. 2016;12:e1005980.
#=GF RN   [2]
#=GF RM   27907154
#=GF RT   Pheromone Recognition and Selectivity by ComR Proteins among
#=GF RT   Streptococcus Species.
#=GF RA   Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna
#=GF RA   G;
#=GF RL   PLoS Pathog. 2016;12:e1005979.
#=GF DR   INTERPRO; IPR040799;
#=GF DR   SO; 0001068; polypeptide_repeat;
#=GF CC   In Gram-positive bacteria, cell-to-cell communication mainly
#=GF CC   relies on extracellular signaling peptides. ComR is a member of
#=GF CC   the RNPP family, which positively controls competence for
#=GF CC   natural DNA transformation in streptococci. It is directly
#=GF CC   activated by the binding of its associated pheromone XIP [1].
#=GF CC   The crystal structure analysis of ComR shows that it contains an
#=GF CC   N-terminal helix-turn-helix (HTH), DNA binding domain (DBD) and
#=GF CC   a C-terminal tetratricopeptide repeat (TPR) domain. The TPR
#=GF CC   domain is composed of 11 alpha-helices forming 5 TPR motifs
#=GF CC   followed by an additional C-terminal alpha-helix 16 called CAP.
#=GF CC   The pheromone XIP binding site is found in the TPR region.
#=GF CC   Biochemical and mutational analysis indicate that, if the
#=GF CC   interacting XIP is accepted it can then trigger the
#=GF CC   conformational change of the TPR domain to open the DBD-TPR
#=GF CC   interface to allow dimer formation that is required to bind DNA
#=GF CC   [2].
#=GF SQ   68
#=GS A0A139NHK9_9STRE/15-234  AC A0A139NHK9.1
#=GS A8AZ57_STRGC/75-293      AC A8AZ57.1
#=GS A0A2L0D697_9STRE/78-290  AC A0A2L0D697.1
#=GS E1M6K7_9STRE/1-73        AC E1M6K7.1
#=GS A0A242K5G9_9ENTE/1-126   AC A0A242K5G9.1
#=GS A0A380K4I3_9STRE/72-294  AC A0A380K4I3.1
#=GS Q8CY78_STRR6/98-165      AC Q8CY78.1
#=GS K1LYB9_9LACT/75-296      AC K1LYB9.1
#=GS A0A2X3VIM9_9STRE/75-293  AC A0A2X3VIM9.1
#=GS A0A3P1VDL4_9STRE/75-293  AC A0A3P1VDL4.1
#=GS A0A242K4G0_9ENTE/75-293  AC A0A242K4G0.1
#=GS A0A5C5TCY1_9STRE/75-293  AC A0A5C5TCY1.1
#=GS A0A6M0L5D2_9LACT/75-295  AC A0A6M0L5D2.1
#=GS A0A380K3S0_9STRE/1-164   AC A0A380K3S0.1
#=GS A0A380K4J4_9STRE/76-120  AC A0A380K4J4.1
#=GS Q8DWI6_STRMU/73-296      AC Q8DWI6.1
#=GS A0A172Q9J0_9STRE/77-295  AC A0A172Q9J0.1
#=GS S4DAL8_ENTFL/73-292      AC S4DAL8.1
#=GS A0A139NAG1_9STRE/71-295  AC A0A139NAG1.1
#=GS J1DMI9_STREE/1-127       AC J1DMI9.1
#=GS A0A3P1V774_9STRE/74-297  AC A0A3P1V774.1
#=GS A0A3L8GRC0_STRIN/72-295  AC A0A3L8GRC0.1
#=GS A0A139NGW5_9STRE/72-296  AC A0A139NGW5.1
#=GS F5X439_STRPX/73-294      AC F5X439.1
#=GS A0A1T4MJM7_9ENTE/73-293  AC A0A1T4MJM7.1
#=GS A8AZ18_STRGC/75-293      AC A8AZ18.1
#=GS J1P3S6_STREE/76-160      AC J1P3S6.1
#=GS J1NTA4_STREE/8-83        AC J1NTA4.1
#=GS G5KFI5_9STRE/73-240      AC G5KFI5.1
#=GS Q8E2E0_STRA5/73-296      AC Q8E2E0.1
#=GS A0A380K385_9STRE/73-294  AC A0A380K385.1
#=GS Q8DVT6_STRMU/75-294      AC Q8DVT6.1
#=GS A8AZW8_STRGC/82-296      AC A8AZW8.1
#=GS A5MCD8_STREE/76-290      AC A5MCD8.1
#=GS B9DST9_STRU0/72-295      AC B9DST9.1
#=GS Q5M612_STRT2/75-294      AC Q5M612.1
#=GS A0A2X3W5P8_9STRE/73-296  AC A0A2X3W5P8.1
#=GS A0A3L9DNT9_9STRE/73-296  AC A0A3L9DNT9.1
#=GS A0A0E4CTV3_9STRE/73-296  AC A0A0E4CTV3.1
#=GS E1M6K6_9STRE/71-193      AC E1M6K6.1
#=GS G5K5D9_9STRE/73-296      AC G5K5D9.1
#=GS A0A172Q9H5_9STRE/75-281  AC A0A172Q9H5.1
#=GS A0A1L8QQ60_9ENTE/1-211   AC A0A1L8QQ60.1
#=GS Q9A1Y2_STRP1/73-296      AC Q9A1Y2.1
#=GS A0A4R0QFG6_9STRE/1-207   AC A0A4R0QFG6.1
#=GS A0A242K4M9_9ENTE/75-165  AC A0A242K4M9.1
#=GS A0A242K4G7_9ENTE/75-293  AC A0A242K4G7.1
#=GS G5JQ00_STRCG/75-294      AC G5JQ00.1
#=GS A0A242K672_9ENTE/1-112   AC A0A242K672.1
#=GS A0A2L0D265_9STRE/72-295  AC A0A2L0D265.1
#=GS A0A172QA32_9STRE/72-295  AC A0A172QA32.1
#=GS A0A1Q8E6R5_9STRE/73-296  AC A0A1Q8E6R5.1
#=GS A4VSD6_STRSY/78-299      AC A4VSD6.1
#=GS A4VSD6_STRSY/78-299      DR PDB; 5FD4 B; 78-299;
#=GS A4VSD6_STRSY/78-299      DR PDB; 5FD4 A; 78-299;
#=GS Q8DND0_STRR6/70-291      AC Q8DND0.1
#=GS F9PYQ6_9STRE/1-142       AC F9PYQ6.1
#=GS A0A1E5GSY1_9ENTE/63-280  AC A0A1E5GSY1.1
#=GS A0A1Q8EB20_9STRE/75-295  AC A0A1Q8EB20.1
#=GS A5MAB8_STREE/8-229       AC A5MAB8.1
#=GS G5KFI4_9STRE/1-49        AC G5KFI4.1
#=GS A0A1G6BIT0_9STRE/73-296  AC A0A1G6BIT0.1
#=GS G6ENH8_STRTR/75-294      AC G6ENH8.1
#=GS A0A1Q8EAZ8_9STRE/74-280  AC A0A1Q8EAZ8.1
#=GS A0A172Q9D4_9STRE/76-290  AC A0A172Q9D4.1
#=GS A0A380K563_9STRE/74-293  AC A0A380K563.1
#=GS J0V3D8_STREE/2-124       AC J0V3D8.1
#=GS A0A139NGV0_9STRE/15-234  AC A0A139NGV0.1
#=GS A0A139NN13_9STRE/1-218   AC A0A139NN13.1
#=GS A0A139NF75_9STRE/74-297  AC A0A139NF75.1
A0A139NHK9_9STRE/15-234             .......PDSYYEKKNRLIK.FP.TYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDIFESVMNFSLLEKGPKTEEIFEDVFLQAQKKKKLSTNDLLVIHYYFL.....--ENHDKKYLDKKILEMLCR...KLLNQEISADETHNITLIVVLMSCA.AVYLMLEEFKTILPIANRLLQFVDEAQLQTYKPGALALKAKYYSRYLGDSERANRYYDKALSFARLLNDDALVRGIKQEK....................
A8AZ57_STRGC/75-293                 .......PSGYLELKYRLEK.LY.HYGDGERLQQREELIEEIYRKYFDQLPEEEQLYLQIKQAKNDMVLTENIAYDQGLIDEYLDQALAKEKLTEMDLEIIDLRLL.....---ALGLKDFDKKEFTCLLN...KLLVAVADYPTNGLEKIQTRIIFAA.GVLSHYQEYDRLPEILRVLEELMLRRNDFQDRVFSYALQWKIALFLENNLEKAEDNYQKVKLMLELLPEDVLKENMRLDW....................
A0A2L0D697_9STRE/78-290             .......PQSYVSLKRRIVQ.FK.SYEDPERLNYLDGLMDEL-QTYYDSVPEEEQMAIEVLQADLDVFVTHKTAFAEQLIEEYFEQVLLKKAYNWNDYLLISLYLF.....---LCAVGIEDSRYFDYFIP...SIFSKGDLSDPDIAYQMEEVVLAVL.AQEN----VAYYPDCIDTLDRVIKVTKHYQNKPILEMFKAKLAL-FQGDIEQMESSYQTAFLIAESLDEPILLNRLKME-y...................
E1M6K7_9STRE/1-73                   ....mgl-------------.--.----------------------------------------------------------------------------------.....--------------------...-------------------------.--------FHYFKRAIEALNKIGQKTRDFQKQPIVLMLEWKYYI--QTDYDTAKKKYEEAKMMARMFGNEQLIVSLDNEW....................
A0A242K5G9_9ENTE/1-126              .......-------------.--.--------------------------------------------------------------------------MIIELYFH.....---CIHFKDYDEQLFMTLSD...KVIEQVDYSVDVELFLLIKVLLVAI.SVFIEYDNYDRLIGAVKVANLIMQTNQDFQKKPAVDVFEGKYWLFSQGDVNRAEQKYLD---------------------gaqsvsythldvykrql...
A0A380K4I3_9STRE/72-294             .......PKRYNELKYLILR.IP.TYSDKERLKEREQQFEEIFEDYYDNLPEEEQLIIDGLQSKFEVYQSGNIHFGTDMIAEYFHQVKKKKSYTLNDLAIIDLYLLi...aAISQFDEQHFQKEDFKIICD...TLLIQGEELAVEDRFLLNNLLLNCV.NIALNLKLAANIQPMLELSHKTMVLIQDFQKMPIYNMYRWKYAL-LQDNQTEAEDYYNQSVMFSKMLNDEHLIQQLDDEW....................
Q8CY78_STRR6/98-165                 .......-KEYLELKYFLMR.TP.TYEDETIAQKKESVFDKIFEEYYDRLPEEERFII------------------------------------------------.....--------------------...-------------------------.--------------------------------------------------------------------------------pnysylalanytvqklpekl
K1LYB9_9LACT/75-296                 .......PFEYYQIKDRLMN.FA.SYGLKDKIQEKDDLYEIVFQKYYDYLPEEEQIAIDIMHATSDVVNEHIDLYGQAIIDDYFDQVKLKSSYTLNDLLIIRLYLS.....QVDFTNEQYFDDNLIDTMLS...KVLNQVDFIHYNMVNFGISFYIDSI.TTLFHYKNFNRIEEILTCLDTLIHIDKKAEDLIICTMLKAKWYLYAKNSIPMTKYFYQQAIDYANLFNEVFLADKLTDE-l...................
A0A2X3VIM9_9STRE/75-293             .......PDEYFTMKYQLFK.FP.TYGDKERLAQKAQMIEDIYEKYFDCLPEEELYTLELSDNTLDYISTGKTAAAEDIFEDFFKQLFLKKKYTFNDLLLVSYYAV.....---QCQNKGYEEEVLKSLEA...TVLKQDVSGDEYYNIELLGTLTAIA.GVYLDHAEYSQLKILADRMHDIIAETQQHSAKPIALIYDAKYYLYAENNVEKAKECYDLATLLAQNFGDNILEANLRDE-r...................
A0A3P1VDL4_9STRE/75-293             .......PQRYLDLRYKMQR.LP.HYGNPERIMEREAILDEIYESFFDNLPEEEQLAVQIEHALLDIAATRRPEFDQGLVDEYLERSLAKSQLDMNDMNILFLRQ-.....--LILAFNGFDKEEFVNLLS...RIIHQRTNTTVEGLRLIQNVVISSI.GMLCHFEEYDMLYQLHQVLEELMELIKDYSDKAFVYMTRWKINLYLEHNLEAAKENYSSARQLAQLLSEELLFTNIRNEW....................
A0A242K4G0_9ENTE/75-293             .......PKGYLQLKRRLYK.FY.TYKEQERKAKKNQLFKEIYETYYDDLPEEEQLSIDVQSATNVLAMTDNVEFGEGILGDYFSQVMQRQEFSVNDLLIIELYLF.....---YIHLREYDEVVFLSLFN...KLVKQIDCSLDVDQFLLIRVLIVSI.SVFIEYGNYDKIIDAVTAADRVMKSNQDFQKKPILDMYEGKYYLFSQKDSTSAKQKFEEGAKLAELQGDSVISQKILKEW....................
A0A5C5TCY1_9STRE/75-293             .......PESYFEKKYLLFK.SS.SYGNTERIAEKHRIIEEIYQEYFDLLPDEELLTLDLIERLLDWRLHSEGERADSLFADYFEQVLIKDVYVLNDLLLLQYYAV.....---QCQDVTYESEKFGICFE...KVRKQAIQGNEFYNVALLGVLSAFA.GSYLVSQDYEKMLQTVERMDEIIQQTLQQVYRPVTLCFRAKYAVYQSRDKQKAQQAYDMAILLAKDIGDDILWTNLTKEK....................
A0A6M0L5D2_9LACT/75-295             .......PEEYYDLKKRIIQ.LH.TLQHKEKTQEKEYLFKQIYTHFFDSLTTEEQLSIDILQKEMQIVTTKDFSVGKAILEEHFDHVKRKRTYSFNDLLIIDIFFL....sILAEVNDFHIYKYYINKFKQ...NLLNHECYYHSEYY-IIQKCFFALL.GIITQYDDFSDFYLCLNKLKEILTYTHDIEKKPIINMLEAKYFI-YKKDFKLAKNFYTSAIKGAQYLNDTPLEEKILLE-m...................
A0A380K3S0_9STRE/1-164              .......-------------.--.------------------------------------MQAQLDVFTSRDYQYGLTLLEEYFQQILKKSHYSYNDLLIINLYFF.....---CCALGLEDKSHMEQLAS...RVIEDIDYSDLDRVYATERILVTLL.----INAEPEDYLTYTSVLRDIIERTNNFQHKPAVYAFEAKYYLLVKKDKAKAKALYDKAILFANMLNDEALAEEFIRE-s...................
A0A380K4J4_9STRE/76-120             .......PKRYLELKNRLTK.TH.TYGDPKRIKELEGFLDEIYEHYYDSLPEEE----------------------------------------------------.....--------------------...-------------------------.--------------------------------------------------------------------------------....................
Q8DWI6_STRMU/73-296                 .......PSRYKELKYLLLR.TP.TYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVNDLILIDLYFSc...lTVSGLDSAIFDSRKYNQLLE...TLLKQVDCLPLEDLFVLNNVLLNNF.GLLLELKKYDFVKQLIAVSNKIMDRTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEW....................
A0A172Q9J0_9STRE/77-295             .......PDSYFRMKYRLFK.IP.SYSDPQRLDEKIELIETIYDHYFSLLPEEELFTLDLLDNIFDYLRKGQRPAAEDSFAEAFKELLLKPRYSLNDLLLAKFYLI.....---QHHSGAYNKALVQKMET...RALKQEISGDDYYNLELINFFSDLS.ALYTSHAEYPKLDVPVKRMHDLIRETRQDSMIPLTLMFEAKYYIYVKQCRNKAEELYNAAVWLAESFDDVLLKTKLIHE-r...................
S4DAL8_ENTFL/73-292                 .......PRRYLELKDLLFK.SPaTHENKERASKKEEYFDEIYENYFYLLSKEEQLTIELKQIRLDVHMTKNINYCKPILEEYLEEVRDKEYLSLNDIMVIDLYFD.....---YVYEIGYQEKEFNFFVD...KLINFIPYAVDLELIVLDSAFTSAC.GVDNKYENYHRFIKYVEAGRKIMEKNFDYSSIPIWMVIEGKYYLFHEKNKQKAITLYEQAIKQAKFVNDIYLSEFLAEE-l...................
A0A139NAG1_9STRE/71-295             .......PKRYQELKYFLLH.HP.DYGDKELQEQKEEYFDEIFECFYDKLPRDEQVMIDCLQAIDQVRATDNEQYGQGIIEDYIETLKNQSSFSANDFLKLRLYFLc...mGAEYFKQGTLSKKEQADIKRlfeMVCNQVEQVETSELFLVRDTLFASL.GCCETMGALELFEIAIEKLKWITEKTRDFQKTPIIFMVEWKYYI--QTDFNLAYQRYQEAIMFAKLFGNEQLIQSLDGEW....................
J1DMI9_STREE/1-127                  .......-------------.--.-------------------------------------------------------------------------MLIIELYFF.....---CCAMGLEDKEHFEELAQ...KVLLCSEYEDKASLVQMEKVLLSLF.IQIQ----TEDSLIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQVLVQRILAE-k...................
A0A3P1V774_9STRE/74-297             .......PRRYKELKYQILR.AP.TYLDEVRLQEREAQFDEIFTDYYDQLPEEECLMVDCIQATMDVALSQNIDFGIGIIQDYFEQVKRKKHLLENDLILLELYFIc...lIISNFDAKIYNSQNFDNLVE...NLLEQEKYGDIDNLFLVNKALIKAF.GASVRLKKYKKLEEIAVTCRRIMTTTGDFQKMPILNLIEWKYYLYSLNDLPSAEACFENAIKFSQIISDDYLEENLNSEW....................
A0A3L8GRC0_STRIN/72-295             .......PKRYKELKHLILR.TP.TYKDKEKVRIREKQFDEIFINYYDNLPEEEKLVVDGLQASLDVALSKNINFGSDILNDYFEQIKVKSCFTRNDLIIIDLYLIc...vRTSKFSDAIYDAAVYKSLLK...KTIAQIDCAEIDDFYVLNQVLITFY.TISIQLDRPKELELIISNCNRIMSVVNDFYRMPILYVMEWKYSIKYLDDLKKATSFYHKAKLFAQMTGDSDLANKIEKEW....................
A0A139NGW5_9STRE/72-296             .......PQEYLSLKYDILN.TQ.VYRHPDLMTQVLKQISDVHERFYADLPQEEAYIFGLLEKMLRAYNLEEDQMPITEIKEHLRPLLNHLYFDLNTLIMIRYVLNre.isYDEKYKKSLFGASYIAMVQE...ELVNLTTTVRREDWFICRDNLITAL.TLSLNHADHEKCFLLLKVLKENMARFQDVQKKMIVMMLEWKIFL-LNNQLDEAQETYDKTKAFVQIIGDKHVLMKIMEEW....................
F5X439_STRPX/73-294                 ......t--RYKELKYLLLR.TP.TYGDEERLKRQTSYFDEISEKYYEVIPEEERLIIDCLQSKLDVHFSDDVNFGEGILNDYFDQVIRKKNFQINDLVLIDLYFAc...lASAKSFVGIYSLDLYDKLME...CLLDQENLSPETS-LILNNVLLNNV.DLVLRFHRESFMKRIIIKSDTIMTSVHDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLENKLIEEW....................
A0A1T4MJM7_9ENTE/73-293             .......PKRYLELKNLLFRgIK.VYQNEERAETVDEQFDEIYNNYFEDLPRYEQDTIELKQILHDMTLTKTAGSAEEIIAESFDRVYKKDDLDLNDFLIIKLYFN.....--LSILKNEVDTEEVKTLSQ...KVIEKIESAIDLELLVIGSILTSIA.IILIEKKNYEELLKIIEIGEKLRKKTLDFRSKPVFCMLKGKCILFHQKDPELAKQHYQEAITSAEMLEDSFLSEKIKEE-l...................
A8AZ18_STRGC/75-293                 .......PPEYIDLKYQLQT.LY.HYGDPERLRLLEKIIDEIYENYFENLPEEEQLSIQIAQATVDMVSAKDPSFDQGLLDEYLEQAMKKKELSFNDVEIIQLRLL.....---SLALGDFNQEEFVDLLG...KVILAADYFPLSDLEKVQNTIVSAA.GVLAHYGIYDILPDIVNVLNDIMTKRRDFQDNIFVHALNWKVALFVEDNLEKAKNDYQKVCMMADLLSEDLVKRNMQEEW....................
J1P3S6_STREE/76-160                 .......PKGFLKLKDELIH.SQ.TYADKGRIERKEAILEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKRNIF-------------.....--------------------...-------------------------.--------------------------------------------------------------------------------l...................
J1NTA4_STREE/8-83                   .......PPAYLELKYQILR.EP.IYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHM----------------------.....--------------------...-------------------------.--------------------------------------------------------------------------------s...................
G5KFI5_9STRE/73-240                 .......PKRYKELKYLILR.TP.VFTDVSKINLREQQLDEIYEIYYDELPEIEKLAIDCIQATLDTSLTKDVNFGIGILNDYLIQTKKKKKYQINDLILINLYLAc...lDITKKKGNLYDSHFYKTIFE...IIQQNVQNYHIEEKFIVQQILIQYF.LLSLYYEEFDYLCDIVKLTKQIL---------------------------------------------------------d...................
Q8E2E0_STRA5/73-296                 .......PKRYKELKYLILR.IP.TYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLNDLIIIDLFLTc...aVVSKFNNRAFTKEVFQTICK...TLISQNHKLTAEDLFWFNHVLLNCV.FVGLCLNSEECLAEMLEVSRQTMVSTHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEW....................
A0A380K385_9STRE/73-294             ......a--DYLELKQKLLR.IP.TYGDQARLKEREQYFTSIYERFYDQLPEDEQLIIDCLQSKLDVHFSDNDSFGLGILQDYFEQTFKKSTYTVNDFVFFDLYLVc...fAYKKNQEHFYEEEQYDLVMA...KLLNSNPPLAEE-KFQLNNVLLNNI.KLAFGLEKWDIIENIVSKSNQLMTEIHDFQKRPILSLIEWKYQLYAKQDTALATQSYQNAILFAKLIGDDYLEKQLSQEW....................
Q8DVT6_STRMU/75-294                 .......PDDYWELKGQIVK.FP.TYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAFNDYLYMSYFLQ.....--KCGKTADYDQTTFKLLEQ...KLLKQELTVDELYNIELLIAVMEAS.GVYALHNDYQNLLPLMKKAQRIIDKAQLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEM....................
A8AZW8_STRGC/82-296                 .......PKRYLELKNKLIR.SH.TYGDEERISILEEMFDEIYENFYEHLPEEEQLLVEVLQVQLDVFSSRDITYGLSLLEEYFQQILKKKKYSYNDLLIINLYFL.....---CCATGLEDKTYFEELSK...KVLLYIDYSDNDRIYILERILIGIL.IQVK----TEDYLIYTKVLREITESTNNFQHKPAIYAFEAKYYLKVEESYEKAEQSYNKAIEFANLLNDQVLASNLLKEK....................
A5MCD8_STREE/76-290                 .......PKGFLKLKDELIH.SQ.TYADKGRIERKEAILEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVNDLLIIELYFF.....---CCAMGLEDKEHFEELAQ...KVLLCSEYEDKASLVQMEKVLLSLF.IQIQ----TEDSLIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQVLVQRILAE-k...................
B9DST9_STRU0/72-295                 .......PKRYQELKYLILR.HP.TYMNTDSIEERESQFDIIFEDYYADLPEEEQVLIDRLRSRFEVYQSGNSVYGQDLLLEYIDQIKKKKTYDLNDIFFIDLYLTc...gYVSSFKETLFDKGIFECFTS...KLILLEEKLDFKDLFLLNNVLMTAI.AVGLTLEEYVKIRTLLNVCRRIMTITQDFQRMPIYYMYEWRYTLFHEKDFRKAPYYYQQSLLFARTHGDEYLKTMIVNAW....................
Q5M612_STRT2/75-294                 .......PDEYYEMKNRLIK.FP.TYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF.....--HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLMAIA.ALKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk..................
A0A2X3W5P8_9STRE/73-296             .......PRRYKEIKYLLLH.TP.TYGNQAKLEERESLFDDIFNNYYDHLPEDEQLIMDALQSKLDIHFSDNINFGRGILNDYFDQVLLKDYYQLNDLIIIDLYLSc...lTINGLEDSIFRQSAFDRIIE...VLICQGDSLPLDDLFMLNNVLLNNF.ELFFLLKKHKEIEEIILLSNNIMQKIHDFHKKPVVNILEWKYYLLVKNDVKKAEESYHSAVMLAQLIGNAYLAEKLEEEW....................
A0A3L9DNT9_9STRE/73-296             .......PKRYKELKYLILR.TP.TYLDEERLKVREEQFDEIFEEYYDKLPEAEQVLVDIVQARFEVFNSGNKEFGSSILEDYFEQVKKKKFYGINDMALIDLYLIc...vLVENFDVEFYDEVTYNQFIQ...NLRNQGSYLNVEDLFFLNKIYLIIC.SVLVKKGDYAQLEDYLDELYHLILKSQDFQRMPLYYMYRWKYSLSYLDDKNSAEEFYAHAILFAEMTSDLYLVKKLKDEW....................
A0A0E4CTV3_9STRE/73-296             .......PEDYLNLKYDILR.TP.TYGENKKIDWRDQILTEIYDNYYDDLPEEEQLAVDTIQSFFDVHDTSEAIYGKEILEEYFFQISHKDAYSINELLMIRLFLEh...aRMTELSKFPKENAVFQHLLK...TLPCQVNVVRPKDLFILRDVLFVMV.GVAGSKEQNDCIPAFIQTIEQIMNRTQDYQKLPILKMISWKYKLYVDKNKKDAEQLYEAAKLSAGMIGDPNLLEKIENEW....................
E1M6K6_9STRE/71-193                 .......PKRYQELKYFLLH.HP.DYGDKELQEQKEEYFDEIFECFYDDLPRDEKVLVDCLQAIDEVRATGNSLYGTSLLENGLHNLLFRDVYKAEELLRLRLYFAc...nLMDGLKAGEIKESEHETILY...-------------------------.--------------------------------------------------------------------------------fmin................
G5K5D9_9STRE/73-296                 .......PKRFKELKYLILR.TP.TYMDGDKLKTREAQFDEIFEDYYDQLPEVEQLVIDCLQSKFDVYQSGDINFGSPLIQEYINQISKNTKYQLNDLLIIDLYLTc...aVVSNFSKYHFDLSLYQEFVN...TILKSEEELLLEDLFMLNNILHTCL.DVSIRLKDYLKVEQMLLLSQKIMSRIQDFQKIPMYCMYYWKYALYHLNDFAKAKHFYEQSVMFTSLTNDNYLVKKLEKEW....................
A0A172Q9H5_9STRE/75-281             .......PQAYFEQKYKLIK.FP.SYGDAERLAPKK------------QLPEEELFTLDLLEKSFDRMTVGESGSAEQIYEDFFKQLLSKETYSLNDILLVKYYFI.....---QCQDSVFDRKTFQHLVA...RLLKQEITGDEYYNVELLGALSALA.GVYVVSADYSDMKPTLDKMDDVVNQTMQHVYKPILLMLEAKYYLYQGHNFQKAKSCYDLALTLAENFGDTVLINNLKKE-r...................
A0A1L8QQ60_9ENTE/1-211              .......-----------MK.QT.MYKDSIRAEKVNLLFDQIYDNFYDQINEEEQLTIDILRATTDIVVFNNVQFESGLLKEYFPQTLLKKELCELDFLLIYLYFF.....YIFGKDKAYKNRNTTKQAIN...KLVKNSDYSNDSNAYLAIKIHIIAL.NFLSELKDYDTYKQLLDISKTISEENQEFQKKPILQMMEAKYLLFHVSDTEKAKVMYRVAAKTAMLLGDNIAHDQIL---lem.................
Q9A1Y2_STRP1/73-296                 .......PKRYKELKYLILR.TP.TYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQNDLILLELYLAy...lDIEGMDGQYSDKIFYDSLLD...NLSEQFEQFELDELFIVNKIIIDIS.SLSLKNNRLDNLEKAIEMSQKIMAKIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEW....................
A0A4R0QFG6_9STRE/1-207              .......-------------.--.--MDQDRIKEREEHFDEIFSEYYDELPEEEQLAIDALQSSFEVYHTGQVDFGVDLIPEYFEQLKKKKRYRMNDLILIDLYLTa...aAISYFDSSIFQKSDFLHFCR...NLLQQRKYLLSEELFFLNRLILTAV.AMRIYLKDADLVLELLNESNAIMEVTEDFQKKSIYCLLQCEYAIFYKKDKELAKHYYEEALLFAKLFNDKKLQEQLQVEW....................
A0A242K4M9_9ENTE/75-165             .......PKRYLQLKQRLYK.LY.TYKEEERIAKKEQTFDEIYENYYDQLPEEEQLSIDVQQASMDVHLAENADFGDGILHDYLYQILQKKEYSINDLLI------.....--------------------...-------------------------.--------------------------------------------------------------------------------....................
A0A242K4G7_9ENTE/75-293             .......PQRYQQLKYKLYR.LV.TYNEEDRLLKRKRYFNEIYEHYYADLPEEEQLAIDGQQATMEVHLKEETDFGEGILHDYFSQITNKTEYTNNDLLIIELYFH.....---CIHFKNYDDTLFMTLLD...HVIDQIAHSIDTTLLLLHKLLLLAA.SVFMEYDNYDRLKSVVNASNDIMKKSQDFQKKPVINLLEGKYWLFAQKDKIKAQQKYEDGAQCAQLFGDFVLSDKIMAEW....................
G5JQ00_STRCG/75-294                 .......PADYFELKHRLVK.FP.TYGDPERVEQKQAMIEEAYEKYFTVLPEEELLFLDLSEKILNWSQTQKIVDIKGIYEDAFEQIQRKKVYTMNDLMVVGYYLF.....--GIHNKKYYDKKLFNKLKN...RLLEQEPSTNELYNIDLLSILISVL.GVYVQHGNYQATLPVIKKIYQLIEKTQQPIYRPSVMMVEAKYYLNIEEDKERATQLYDQAINFATLLGDEVLADGLRDEK....................
A0A242K672_9ENTE/1-112              ......m-------------.--.----------------------------------------------------------------------------------.....--------------FLTLFS...RVTDQIDYSIDIEQFLLIKALIVSI.SVFLEFGNYDKIIDAVTAANKIMNVNQDFQKKPIIDMHEGKYYLFSQKDVPTAKQKFEEGAKLAELQGDSVISQKILKEW....................
A0A2L0D265_9STRE/72-295             .......PFRYKELKYLIMR.TP.TYRQEQQIKQITQYFDEIYLDFFEKLPEDEKIAIEVLQTSMDIHLDEDVNFGGDLVRESFQQIQLKKRYELNDLLIIRLYFFy...iYFANFQDTLFDLSIVKKLCG...YLKKQAQFTHPSDLFLLRDILLQAI.TILIKLEEFQDASDLIEQTRDIISTTQDYQKQPILDMMEWKLILAQHNNRGAAEAKYNEALLFSRIVGNQYLEEQLIIEW....................
A0A172QA32_9STRE/72-295             .......PARYEELKYLIMR.TP.IYADTNRVELVETYFDEVYEQYYDNLPEEEQLAIDILQSSLDVQITDNIEFGSILLQDYFEQVKAKRIYSINDLLIVGLYFYq...iSSESIYSDDISSETLDMLAG...RLILQTHYIVPSYLFLLRDVLLQCG.GMLLLTHSYQHLPAIVQELNTIINKTQDYQKKPLVDMLEWKYYLYVKQNFSRAQQKYQQAVQFSAMIDDAVLKENLEKEW....................
A0A1Q8E6R5_9STRE/73-296             .......PDQYVKLKYDILR.TP.TYNRADLIDKRNGKLKQIYDRFYDQLPDIERVAIDALQSTIDVLETKSDIFGREIVKKHIPRIERKRKYDVNDLLVIHLFMEh...aYLSNLRKKSDSRKMFLKLVA...ELPKQVMLMEPEDLFVLRNVMFATI.RVLGAKEICDPIPALFQGLDQIMQITQDFQKYPIFSMLRWKYELLVHRDVNRASSYCKEAMVFAKLMGNLHLMEQLHAQW....................
A4VSD6_STRSY/78-299                 .......PERYSKLKFDVLR.TP.TYGNEDLAEKRDAMMTEIYDDYYDELPEEEKIAIDAIQSRIDTLESGTAGFGKEILEDYFEQIFRKRKYELNDLLIVRLHLEy...vRLSSCDSEIF--RQFLKIIE...HLHEQINIINSNDLFVLRDTLLSCV.NILGSKKYYEPIPKIFDSVDKIIQSTQDFQKKPIVSVLKWKYALFVDKDRDEAEKHYLDAVLFAKLIENRELEQKIEEDW....................
#=GR A4VSD6_STRSY/78-299      SS    .......-HHHHHHHHHHHH.--.-TT-HHHHHHHHHHHHHHHHHTGGGS-HHHHHHHHHHH-----SS--SSSS-HHHHHHHHHHHHH-SS--HHHHHHHHHHHHH...HCCS-TTSHHH--HHHHHHHH...HHHHHTTTS-GGGHHHHHHHHHHHH.HHHHHTT--TTHHHHHHHHHHHHHHHT--TTHHHHHHHHHHHHHHTS--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHH....................
Q8DND0_STRR6/70-291                 .......PSAYLELKYQILR.EP.IYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY.....QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLISGM.CCLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAKLIGDGFLVKELTEEW....................
F9PYQ6_9STRE/1-142                  .....ml-------------.--.-----------------------------------------------------------------RTEYSTNDLLLLYLYFL.....--SLAVNAERDEITLKKVCL...NIVSQTNYDDTNYIHLLQRVLIGLV.LYQLDIDYHEFIPEILSILREIMIDIGDTSLKPTVDFIEAKYYLYGEKDKEKALQYYEKAINGAEFLNDMNFKNRVIEEK....................
A0A1E5GSY1_9ENTE/63-280             .......PERYIRLKMSLFK.RP.PQYNHAMEKIVEDIFEEIYKDYYEVLPEEEQLLVDIAQAQNDVNLSEKIDFGEGILQEYFFQVKNKKEYSENDLLIVHLYFG.....---CCHYKPYDDQEFDTLVE...KCLEQVNYSSELGLIILNRVLGTIA.GLYIISDQYDKVLNVIKISNTIMKMSQDFHRKPIIDMVEGKYWL-HCNDIEKANKKYNDAMVLAQLHGEDLLAERIKMEW....................
A0A1Q8EB20_9STRE/75-295             .......PQDYLDLKYLALR.LS.AFGQEEKLDEMAACVEEMAERFYDQLPEDERVIIWILRCRIRMCRGIKPATRTQIFDDYLEQVQRRKVYGINDLLLIHVYFL.....-ACQLIEDLLEEPFYRQMVD...CLLEQDQHLKIEEWFILRDVLIACL.TAGLQYGLAYKHREMLALLEQMMELTQDYQKKAVVYLLEWKCAMMFRQDVALARKSYQQALAFSHVLRDTYLRQQLMSEW....................
A5MAB8_STREE/8-229                  .......PPAYLELKYQILR.EP.IYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY.....QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLISGM.CCLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEW....................
G5KFI4_9STRE/1-49                   .......-------------.--.----------------------------------------------------------------------------------.....--------------------...-------------------------.-------------------------------MPIICIMEWKYFLNCLLDFKKAKSCHTKAILFANMMGDDYLEEKINEEW....................
A0A1G6BIT0_9STRE/73-296             .......PKRYTELKYLILR.TP.TYMDAERLRIREEQFDEIYEKFYEELPEDEQLTITFIQSKFEVYQTGDTEFGTDVIEDYFKQVQKKKLYTLNDIVLIDLFLTc...sIVSNFTSHLFDNAIYELLSS...NLIKQSEYLPIEDLPLLNSVLLVCA.DASVRLEKFNLLSNLLSASHSLMTKIQDFQKMPIYNMLMWEYYLFGENNYVQAENHYNQSILFAKMMNDIHLAEKLEKEW....................
G6ENH8_STRTR/75-294                 .......PDEYYEMKNRLIK.FP.TYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF.....--HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLMAIA.ALKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk..................
A0A1Q8EAZ8_9STRE/74-280             .......PKRYLDLKYLVMR.TG.LFGQSTLVAQKEAYLLEMYEEFYDDLPEDEQVAVDVLQSWVDVFVTGQPTFGNRMLEEYFEQVKQRSVYQVNDLLLLELYFY.....-CVYLDNSLFNRRLYRHFVN...GLLAQDQHLPVEQLFLLSTVYVTCV.AVGLNNGYCDGIGQLVKQSKEIMKQIQDFQNLPIVHLQECQILF--LKNRQLAEK-------------------------kveellnsistig.......
A0A172Q9D4_9STRE/76-290             .......PKRYLELKNRLIK.SH.TYGDKERIAKQEEIFDEIYNNYYDFLPEEEQLLVEALQVQLNVFTSRDIGFALGFLEEYFQQILTKKNYSYNDLLIVYVYFT.....---CCAMGLEDKEYFDELSK...KVLLHVDYSDLEKLYLVERVLLSIL.VQVD----PTEYLIYTKIFREIMKESNHFQHKPVVYVFEAKYYLDIEQNKNKTIESYDKAIMFAKMLNDEVLARNIEIEK....................
A0A380K563_9STRE/74-293             ......s-KDYLKLKVEFIR.LS.TYDDSDRKAKKEEIIDTIFEKYYDNLPSDEQLTLTILSTEMEMLHSKDTTYGEELFKEVQSKIFNIQRITVNEILWMNFYLV.....-YISGREDLYSKEKINDILA...IIISI-DNDDELFLELEIKLCVTLC.GVMIWSNTLEKFSKLRPTFKRLILKHSDSKSIPIYHMMNGKYAMLVEGKRREALLHYDRALEEARFLEDDILYQRISEEM....................
J0V3D8_STREE/2-124                  lirkdla-------------.--.----------------------------------------------------------------------------------.....---------KFINQIEKLML...FLLEQKKVTKLENFFIIRDTLISGM.CCLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEW....................
A0A139NGV0_9STRE/15-234             .......PDSYYEKKNRLIK.FP.TYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDILESVMNFSLLEKGPKTEEIFEDVFLQAQKKKTFLLNDLLVIHYYFL.....--EIHRNKYIDEKLLGQLER...KLLVQEISSEEVYDILLITTLMDIA.TIHMLKDDYKPILQFVNRVLQIADEAQLHTYKPIATTMKAKYFNHYEHNMEKAEQYYDEAMAFAKLLGDDVLAQGIKQEK....................
A0A139NN13_9STRE/1-218              .......----------MLR.RP.TYGNEELLEKKDQVFREIYDDYYDNLPVEEQMAIDAYSSGLDILRTEDAVYGNEIIHRHFYEIYEKEFYTINDLIVIRLFIIwldtsHQQQTNDVSKNMVYLENLAE...KLPKQRDNYDLEEVFVLRDLLINLIiQMGRFQLKLEKLPELFDVVEDIMEESHDLQKKPVLLQLKWTYYLKVKDNYEEAYRCYQDALQLTQLLGDAHLKALLES--vw..................
A0A139NF75_9STRE/74-297             .......PEDYLKLKYQLIR.TT.SYGDKDVLSELDEAVDAIFARYFDDLPEEEQFIIEVLQSKLYTYEMEGERFGKPILEENLSKLRDKKQYTINDLLIVDLYQTh...lDDEDLLSKSFDIDCFNAIVR...TTLDSIEGLGREYLFKARDVLLYVP.YAEFIRKDFRYSKEVLECLNTIMTMTQDYQQKPLVKMMEWQYLLGYKQDVDGAKECYQEAVSLAKLFGNEFLAEKLTEEW....................
#=GC SS_cons                        .......-HHHHHHHHHHHH.--.-TT-HHHHHHHHHHHHHHHHHTGGGS-HHHHHHHHHHH-----SS--SSSS-HHHHHHHHHHHHH-SS--HHHHHHHHHHHHH...HCCS-TTSHHH--HHHHHHHH...HHHHHTTTS-GGGHHHHHHHHHHHH.HHHHHTT--TTHHHHHHHHHHHHHHHT--TTHHHHHHHHHHHHHHTS--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHH....................
#=GC seq_cons                       .......PpcYh-LKhhlh+.hs.oYtcp-+lpp+-phh-EIa-pYaDpLPEEEplhl-hlpuph-hhhopphtauptllp-aFpQlhpKcpashNDLlllcLYhh........thppthhspphapplhp...pllpQ.phhp.pthhhlppsLlshh.shhh.htphcph.phlphhppIhppspDapcpPllhhhchKYhLhhppshppAcphYppAhhhAphhsDphLhpplppEh....................
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