GenomeNet

Database: Pfam
Entry: Comm
LinkDB: Comm
Original site: Comm 
#=GF ID   Comm
#=GF AC   PF15957.7
#=GF DE   Commissureless
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   Jackhmmer:Q24139
#=GF GA   27.00 27.00;
#=GF TC   27.50 29.00;
#=GF NC   26.80 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12165468
#=GF RT   Drosophila Nedd4, a ubiquitin ligase, is recruited by
#=GF RT   Commissureless to control cell surface levels of the roundabout
#=GF RT   receptor.
#=GF RA   Myat A, Henry P, McCabe V, Flintoft L, Rotin D, Tear G;
#=GF RL   Neuron. 2002;35:447-459.
#=GF RN   [2]
#=GF RM   15657595
#=GF RT   Comm function in commissural axon guidance: cell-autonomous
#=GF RT   sorting of Robo in vivo.
#=GF RA   Keleman K, Ribeiro C, Dickson BJ;
#=GF RL   Nat Neurosci. 2005;8:156-163.
#=GF DR   INTERPRO; IPR031878;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Commissureless regulates Roundabout (Robo) levels and as a
#=GF CC   result regulates controls axon guidance across the embryo
#=GF CC   midline [1-2].
#=GF SQ   87
#=GS Q9VUS1_DROME/143-251      AC Q9VUS1.2
#=GS B0XA54_CULQU/12-112       AC B0XA54.1
#=GS A0A6I8VJZ8_DROPS/60-219   AC A0A6I8VJZ8.1
#=GS B4J034_DROGR/74-147       AC B4J034.1
#=GS B4HIJ6_DROSE/128-263      AC B4HIJ6.1
#=GS A0A6I8VJY6_DROPS/141-249  AC A0A6I8VJY6.1
#=GS COMM_DROME/128-263        AC Q24139.1
#=GS COMM_DROME/128-263        DR PDB; 2EZ5 P; 227-237;
#=GS A0A484BL92_DRONA/112-225  AC A0A484BL92.1
#=GS D5A7L2_DROME/128-263      AC D5A7L2.1
#=GS B4MXW7_DROWI/127-278      AC B4MXW7.1
#=GS B4L0H6_DROMO/112-225      AC B4L0H6.2
#=GS B0W5U2_CULQU/169-249      AC B0W5U2.1
#=GS A0A182Y5Y7_ANOST/120-163  AC A0A182Y5Y7.1
#=GS B4L0I2_DROMO/155-263      AC B4L0I2.1
#=GS B4J038_DROGR/114-227      AC B4J038.1
#=GS B4QL68_DROSI/128-263      AC B4QL68.1
#=GS A0A484BLQ2_DRONA/72-149   AC A0A484BLQ2.1
#=GS Q2M1E5_DROPS/132-274      AC Q2M1E5.2
#=GS A0A182GI49_AEDAL/1-65     AC A0A182GI49.1
#=GS A0A0L0BLV1_LUCCU/534-633  AC A0A0L0BLV1.1
#=GS A0A6I8UC44_DROPS/114-227  AC A0A6I8UC44.1
#=GS A0A182H0E0_AEDAL/108-291  AC A0A182H0E0.1
#=GS B0XD49_CULQU/104-236      AC B0XD49.1
#=GS B4LIH3_DROVI/124-269      AC B4LIH3.1
#=GS Q9VUS2_DROME/69-206       AC Q9VUS2.3
#=GS A0A6I8VJD3_DROPS/1-94     AC A0A6I8VJD3.1
#=GS B4L0I1_DROMO/74-174       AC B4L0I1.2
#=GS B4QL47_DROSI/1-69         AC B4QL47.1
#=GS A0A484BLE7_DRONA/2-75     AC A0A484BLE7.1
#=GS A0A1S3D9B0_DIACI/56-155   AC A0A1S3D9B0.1
#=GS A0A6I8T9V5_AEDAE/97-214   AC A0A6I8T9V5.1
#=GS B3MAC1_DROAN/70-147       AC B3MAC1.1
#=GS B3M9W7_DROAN/105-218      AC B3M9W7.1
#=GS A0A5N4AKM2_PHOPY/38-141   AC A0A5N4AKM2.1
#=GS B4GU91_DROPE/60-131       AC B4GU91.1
#=GS B4L0H4_DROMO/130-277      AC B4L0H4.2
#=GS A0A0L0C6I9_LUCCU/1-67     AC A0A0L0C6I9.1
#=GS A0A3B0KM76_DROGU/114-227  AC A0A3B0KM76.1
#=GS A0A6I8U394_AEDAE/100-228  AC A0A6I8U394.1
#=GS A0A084W1J4_ANOSI/1-60     AC A0A084W1J4.1
#=GS A0A484BP05_DRONA/155-209  AC A0A484BP05.1
#=GS B3M9W5_DROAN/130-268      AC B3M9W5.1
#=GS A0A482WL98_LAOST/28-129   AC A0A482WL98.1
#=GS A0A0P8XUL2_DROAN/144-252  AC A0A0P8XUL2.1
#=GS A0A3B0K8R4_DROGU/144-251  AC A0A3B0K8R4.1
#=GS A0A5E4NQR2_9HEMI/38-135   AC A0A5E4NQR2.1
#=GS A0A084W1J9_ANOSI/124-174  AC A0A084W1J9.1
#=GS A0A6G0YDQ4_APHCR/8-75     AC A0A6G0YDQ4.1
#=GS B4HIH7_DROSE/69-142       AC B4HIH7.1
#=GS A0A0L0CTC2_LUCCU/136-243  AC A0A0L0CTC2.1
#=GS E0VU79_PEDHC/18-131       AC E0VU79.1
#=GS B4J041_DROGR/140-289      AC B4J041.1
#=GS A0A1W4WHV5_AGRPL/40-149   AC A0A1W4WHV5.1
#=GS A0A0T6AXE9_9SCAR/44-148   AC A0A0T6AXE9.1
#=GS B4LII4_DROVI/152-260      AC B4LII4.1
#=GS A0A2J7RF30_9NEOP/15-88    AC A0A2J7RF30.1
#=GS B4JZZ5_DROGR/145-252      AC B4JZZ5.1
#=GS A0A1W4W653_AGRPL/1-102    AC A0A1W4W653.1
#=GS B4MX67_DROWI/160-268      AC B4MX67.1
#=GS A0A2P8YEW8_BLAGE/12-69    AC A0A2P8YEW8.1
#=GS A0A0Q9WKC9_DROVI/77-210   AC A0A0Q9WKC9.1
#=GS D7FN65_ECTSI/79-153       AC D7FN65.1
#=GS A0A6G0YMA1_APHCR/99-143   AC A0A6G0YMA1.1
#=GS B4GU92_DROPE/141-206      AC B4GU92.1
#=GS B4QL66_DROSI/112-225      AC B4QL66.1
#=GS B4K1C0_DROGR/4-74         AC B4K1C0.1
#=GS T1GG69_MEGSC/81-192       AC T1GG69.1
#=GS B4K0Z9_DROGR/12-112       AC B4K0Z9.1
#=GS COMM2_AEDAE/97-214        AC Q172W0.1
#=GS B4GU83_DROPE/114-227      AC B4GU83.1
#=GS B4LIH5_DROVI/111-224      AC B4LIH5.2
#=GS A0A182HCT8_AEDAL/96-139   AC A0A182HCT8.1
#=GS A0A0L0CJK0_LUCCU/135-261  AC A0A0L0CJK0.1
#=GS B4HIH5_DROSE/143-251      AC B4HIH5.1
#=GS B0XA56_CULQU/110-233      AC B0XA56.1
#=GS A0A3B0KV47_DROGU/132-270  AC A0A3B0KV47.1
#=GS A0A6I8W457_DROPS/1-149    AC A0A6I8W457.1
#=GS A0A3B0K669_DROGU/99-237   AC A0A3B0K669.1
#=GS B4HIJ3_DROSE/112-220      AC B4HIJ3.1
#=GS A0A484BCA0_DRONA/130-279  AC A0A484BCA0.1
#=GS B4JZZ4_DROGR/74-160       AC B4JZZ4.1
#=GS J9KFT9_ACYPI/52-161       AC J9KFT9.2
#=GS A0A6A4IKF8_APOLU/104-203  AC A0A6A4IKF8.1
#=GS B4MXW9_DROWI/137-252      AC B4MXW9.1
#=GS A0A182Y5Y8_ANOST/2-80     AC A0A182Y5Y8.1
#=GS COMM2_DROME/112-225       AC Q9VUT8.2
#=GS B4GU80_DROPE/132-274      AC B4GU80.1
Q9VUS1_DROME/143-251                 .................................q-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWK----.................................................----NSYRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..MVpiiKIFE----cnet...........................
B0XA54_CULQU/12-112                  ................aaaecdhqhtpqeiktva-----------------------------..-------..............--------.................................................LPEASALLTAR.SQ..........TLSAMDVETPPPYDVE......SLPSYTIVSGLPSYSDAIEQLKQKQLQRtlgy................agyepVKLQHAS..VI...KLFESQSQ...............................
A0A6I8VJZ8_DROPS/60-219              .................................s-SYRSTSTIVLMVSAWTLLILGFVFCCCAecCGV----..............SVWRGKKRstiealngaerggeggeggagp....rsrpasggggvaastggsgsgsgHHQLSADRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--LLTPS..VVpiiKIFE----cndn...........................
B4J034_DROGR/74-147                  .................................y-SYRSTSTIVLMVTAWILLILGFVFCCCA.eCFG---V..............SVWRGKKRasi..........................................slrgA---ESGAAAA.--..........----------------......----------------------------.........................-------..--...--------aatattiasvnelqaat..............
B4HIJ6_DROSE/128-263                 .................................a-DMHVIINYLWIGVVSSLVILSLVFILFS..CYFYRKF..............RTWKKCNKdiraqihaa..............................sdsysshlvgC----------.-DasrlllhqqmQHPHHRSSEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHH-c..............................
A0A6I8VJY6_DROPS/141-249             .................................q-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWK----.................................................----NSYRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--LLTPS..VVpiiKIFE----cndn...........................
COMM_DROME/128-263                   .................................a-DMHVIINYLWIGVVSSLVILSLVFILFS..CYFYRKF..............RTWKKCNKdiraqihaa..............................sdsysshlvgC----------.-DasrlllhqqmQHPHHRSSEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHH-c..............................
#=GR COMM_DROME/128-263        SS    .................................X-XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXX..............XXXXXXXXXXXXXXXXX..............................XXXXXXXXXXX----------.-XXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXX-----TTSS--XXXXXXXXX.........................XXXXXXX..XX...XXXXXXX-X..............................
A0A484BL92_DRONA/112-225             .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNY-.................................................---HNNANSSS.QC..........TIIDIEALKLQPDSED......PVPEYTLVSGLPSYEAALELLQKTPQSS.........................CLIVYPS..VF...NVFNKHE-r..............................
D5A7L2_DROME/128-263                 .................................a-DMHVIINYLWIGVVSSLVILSLVFILFS..CYFYRKF..............RTWKKCNKdiraqihaa..............................sdsysshlvgC----------.-DasrlllhqqmQHPHHRSSEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHH-c..............................
B4MXW7_DROWI/127-278                 .................................a-DMNVIINYLWIGVVSSLVILSLVFIIFS..CYFYRKF..............RTWKKCNKdiraqihasndsysshg...............vshhliscdasrlllqqQQQHQHQQQQQ.QH..........LSSGNNEMEAAFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHQAQ...............................
B4L0H6_DROMO/112-225                 .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNY-.................................................---HNNANSSS.QC..........TIIDIEALKLQPDSED......PVPEYTLVSGLPSYEAALELLQKTPQSS.........................CLIVYPS..VF...NVFNKHE-r..............................
B0W5U2_CULQU/169-249                 ..................................-----------------------------..-------..............--WNNGYT.................................................PPPTSGTRSTGaGHvf.....lscFATTMGGQLLLSYSTLfcatclDAPEY--VDGLWDYGGRIHR--------.........................-SAWFPA..SV...GVTAGE--ag.............................
A0A182Y5Y7_ANOST/120-163             ..................................PTYERFIGDVWVGIVLTLMILSSIFCMCS..CFLYHKF..............RQWQR---.................................................-----------.--..........----------------......----------------------------.........................-------..--...--------nem............................
B4L0I2_DROMO/155-263                 .................................e-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFLYHKF..............QQWK----.................................................----NSYRANH.GD..........ATIEVCRHCPPEYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPS..FVpviKIFESAS-n..............................
B4J038_DROGR/114-227                 .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNY-.................................................---HNNANSSS.QC..........TIIDVEALKLQPDLED......PVPEYTLVSGLPSYEAALELLHKTPQSS.........................CLIVYPS..VF...NVFNKHE-r..............................
B4QL68_DROSI/128-263                 .................................a-DMHVIINYLWIGVVSSLVILSLVFILFS..CYFYRKF..............RTWKKCNKdiraqihaa..............................sdsysshlvgC----------.-DasrlllhqqmQHPHHRSSEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHH-c..............................
A0A484BLQ2_DRONA/72-149              .................................y-TYRSTSTIVLMVAAWILLILGFVFCCCA.eCFG---V..............SVWRGKKR.................................................ASISRSGAESA.AT..........STTATG----------......----------------------------.........................-------..--...--------dqssqlhavqkckmati..............
Q2M1E5_DROPS/132-274                 .................................a-DMHVIINYLWIGVVSSLVVLSLVFILFS..CYFYRKF..............RTWKKCNKdmraqihaands........................ysshgagspghlvSCDASRLLLQQ.PQ..........QPSAGNNNEAAFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHHH...............................
A0A182GI49_AEDAL/1-65                ..................................-----------------------------..-------..............--------.................................................-----------.--..........----MDLETPPPYDVE......SLPSYTIVSGLPSYNDAIEQLKQKQQQKstgg.................hlepVKIQRPS..VI...KLFESQSQ...............................
A0A0L0BLV1_LUCCU/534-633             ............................nshsnn------AEKVWTTVMLSIVVIGVLIFLFT..CFQ--RY..............MAWR--KK.................................................RIDTEEYRRNH.-D..........EMREIRRLNQRILEEEa...rpNAPNS-FENALPSYEDALT---------.........................-------..--...--------mpkpvrpvksm....................
A0A6I8UC44_DROPS/114-227             .................................l-EYDKFMNEVWIGIVFTLILISLVFCICS..CFLYHQF..............RTWKRNY-.................................................----RNNANNS.TQ.........cTIVDIEALKLHPDSDD......PVPEYTLVSGLPSYEAALELLHKAPKTS.........................CLIVYPS..VF...NVFNKHE-r..............................
A0A182H0E0_AEDAL/108-291             ...............................psl---------LWIGAVMVLLILSGLFCVCS..CYLYYKY..............RRWQKCAApstripfgahgglnpekraiggvrsfmhersvpeqqqqqqkhlihrraaMHVFVAFSSAT.CQ..........TLTSVDIEAPPPYDIE......TLPSYTIASGLPSYEDAVRHIVRQQQQSragyhpatavq..kprsacsnhnsaVSVHPQS..VV...KFFESR--pe.............................
B0XD49_CULQU/104-236                 ..................................PTYERFIGDVWVGIVLTLMILSSIFCMCS..CFLTTSFasgnevvstaagitRSWNNGYT.................................................PPPTSGTRSTGaGHvf.....lsrSATTMGGQLLLSYSSLfcatclDAPEY--VDGLWDYGGRIHR--------.........................-SAWFPA..SV...GITAGE--ag.............................
B4LIH3_DROVI/124-269                 .................................a-DMHAIVNYLWIGVVTSLVLLSLVFIMFS..CYFYRKF..............RTWKKCNKdiraqihaaddsys.....................shgashhliscrflQQPAAGSGVAS.AG..........GSATAGGNEAAFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHHH...............................
Q9VUS2_DROME/69-206                  .................................y-SYRSTSTIVLMVSAWILLILGFVFCCCAecCGV----..............SVWRGKKTrssididglnq..........................aeqggngngsasARDATADRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..MVpiiKIFE----cnet...........................
A0A6I8VJD3_DROPS/1-94                ...........................myvcmyi-----------------------VHIHCT..YYIHSCI..............RDFN----.................................................---IRPDRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--LLTPS..VVpiiKIFE----cndn...........................
B4L0I1_DROMO/74-174                  .................................y-TYRSTSTIVLMVAAWILLILGFVFCCCA.eCFG---V..............SVWRGKKR.................................................ASISRSGAESS.AT..........STTATGNQSSQLHAAL......TTP-------------------------.........................-------..--...--------eqknkkkkklkmkrndpmaqillglsd....
B4QL47_DROSI/1-69                    ................................mk-----------------------------..-------..............--------.................................................------DRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..VVpiiKIFE----cnet...........................
A0A484BLE7_DRONA/2-75                .............................galhs-----------------------------..-------..............--------.................................................----PKDRANH.GD..........ATIEVCRHCPPEYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPS..FVpviKIFESTS-n..............................
A0A1S3D9B0_DIACI/56-155              ...............................sme---EHLVNEVYIVIALTLMVFSSITCVCM..CLLYHKY..............QQWH----.................................................----QHVLESR.--..........PP---TAAPIPSPDTD......SLPSYTIVTGLPSYEEALEQLRQMRLV-.........................-------..--...--------rkssvpvmkysga..................
A0A6I8T9V5_AEDAE/97-214              ..................................PTYERFIGDVWVGIVLTLMILSSIFCMCS..CFLYHKF..............RQWQ----.................................................----RSVLTAR.SQ..........TLSSMDLETPPPYDVE......SLPSYTIVSGLPSYNDAIEQLKQKQQQKspgg.................hlepVKLQRPS..VI...KLFESQSQ...............................
B3MAC1_DROAN/70-147                  .................................y-SYRSTSTIVLMVTAWILLILGFVFCCCAecCGV----..............SVWRGKKR.................................................ASVNDVNRMEA.G-..........----------------......----------------------------.........................-------..--...--------aadgdgggggggrgtaaetnaaph.......
B3M9W7_DROAN/105-218                 .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNYR.................................................NNATNS---T-.-Q.........cTIVDIEALKLHPETED......PVPEYTLVSGLPSYEAALELLQKTPQSQ.........................CLIVYPS..VF...SVFNRQE-r..............................
A0A5N4AKM2_PHOPY/38-141              ..................................PDYEQFLADVWVGIILTLIVLSCVCCMCS..CLLYHKF..............QQWK----.................................................-RHILQARNAN.--..........--VE-----NGNGELE......SLPSYTIVSGLPSYAEALEQLKKVKEQS.........................-------..--...--------apridgagpwtphtppt..............
B4GU91_DROPE/60-131                  .................................s-SYRSTSTIVLMVSAWTLLILGFVFCCCAecCGV----..............SVWRGKKR.................................................ST---------.--..........----------------......----------------------------.........................-------..--...--------iealngaerggdggggsgagpgpgsrpa...
B4L0H4_DROMO/130-277                 .................................a-DMHAIVNYLWIGVVTSLVVLSLVFIMFS..CYFYRKF..............RTWKKCNKdiraqlhaasdsyss...................hgashhliscdasrlLQQVPGNGSGS.GN..........GSSPGGANEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHHH...............................
A0A0L0C6I9_LUCCU/1-67                ...............................mnn-----------------------------..-------..............--------.................................................-------RTNN.-N..........ENVEICRNYPPNYEAE......SLPSYTIVSGLPTYDDAIEEFRKAGI--.........................--ILTPPvpVI...KIFEAK--et.............................
A0A3B0KM76_DROGU/114-227             .................................l-EYDKFMNEVWMGIVFTMILISLVFCICS..CFLYHQF..............RTWKHNNR.................................................SNPNNSTQC--.--..........TIVDIEALKLHPDAAD......PVPEYTLVSGLPSYEAALELLYKAPQSS.........................FLLVYPS..VF...NVFNRN--ei.............................
A0A6I8U394_AEDAE/100-228             ...............................psl---------LWIGAVMVLLILSGLFCVCS..CYLYYKY..............RRWQ----.................................................----KCVSSAT.CQ..........TLTSVDIEAPPPYDIE......TLPSYTIASGLPSYEDAIRHIVRQQQQSrtsggyqpatsvqkprtacsnnhnaVSIHPQT..VV...KFFESR--pe.............................
A0A084W1J4_ANOSI/1-60                ..................................-----------------------------..-------..............--------.................................................-----------.--..........----MDIETPPPYDVE......SLPSYTIVSGLPSYQDAIEQLKQKQLKYy......................epVRVHRPS..VM...KLFESQ--dl.............................
A0A484BP05_DRONA/155-209             .................................e-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFLYHKF..............QQWKNSCE.................................................CTPHG------.--..........----------------......----------------------------.........................-------..--...--------vylish.........................
B3M9W5_DROAN/130-268                 .................................a-DMHVIINYLWIGVVTSLVVLSLVFILFS..CYFYRKF..............RTWKKCNKdiraqihaasds........................systhlvncdasrLLLHQQQQIQQ.--..........--QHQRNNEAAFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPT..LA...AVHHHHHH...............................
A0A482WL98_LAOST/28-129              .................................l-EYDRFISDVWIGVVLTLMVLSCVGCLCS..CFLYHKF..............QQWK----.................................................----RSVLENR.--..........---GMDD-RENTYDIE......SLPSYTLVTGLPSYDEAIEQLRKVNEIK.........................EIPRTPE..LA...K-------lsvgd..........................
A0A0P8XUL2_DROAN/144-252             .................................k-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWK----.................................................----NSYRANH.SD..........ATIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..VVpiiKIFE----cndn...........................
A0A3B0K8R4_DROGU/144-251             .................................q-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWK----.................................................----NSYRANH.SD..........PTIEICRRCPPDYEGE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--LLTPS..VVpiiKIFE----cid............................
A0A5E4NQR2_9HEMI/38-135              ..............................myde----IVLNDVWINAILSTLALSCATCVCL..CFLYCKF..............QQWK----.................................................-LSAQERR---.--..........-----KKKNLRKNDDD......SLPSYTIVTGLPSYEEALERMNSMSA--.........................-------..--...--------stsastsvedgrpe.................
A0A084W1J9_ANOSI/124-174             ..................................PTYERFIGDVWVGIVLTLMILSSIFCMCS..CFLYHKF..............RQWQRN--.................................................-----------.--..........----------------......----------------------------.........................-------..--...--------gkwfsylqm......................
A0A6G0YDQ4_APHCR/8-75                .................syyivtilcvsavqrrr-----------------------------..-------..............--------.................................................-----------.--..........-----NEKNSRKHDAD......SLPSYTIVTGLPTYDEALERMR------.........................-------..--...--------ggynhggaasvrdnkppp.............
B4HIH7_DROSE/69-142                  .................................y-SYRSTSTIVLMVSAWILLIMGFVFCCCAecCGV----..............SVWRGKKT.................................................RSSIDIDGLN-.--..........----------------......----------------------------.........................-------..--...--------qaeqggkwkweclrprcncrfy.........
A0A0L0CTC2_LUCCU/136-243             .................................l-NYDKFMNGIWIGVVLALILISMIFCFCS..CFLYHQF..............RVWK----.................................................----RNYRTTV.-T..........QNNDVEAVKLNLDMED......PVPEYTLVSGLPSYEAALELLHKTPK-S.........................CLIVHPS..VF...EVFNEK--pa.............................
E0VU79_PEDHC/18-131                  ..................................PQYEQLLADVWVGIVLTLLLLSCVCCMCS..CLLYHKF..............QQWK----.................................................---RSALRSND.--..........-ELDVTSSSGMNVDCE......SLPSYTMASGLPTYEEAVQQMDKKSEK-.........................-------..--...--------ssdnnlfksseqwqnienknssvf.......
B4J041_DROGR/140-289                 .................................a-DMHAIVNYLWIGVVTSLVVLSLIFIVFS..CYFYRKF..............RTWKKCNKdiraqihaandsyssh.................gashhliscdasrllqQLPANGSNNAA.TA..........AAAAAGGNEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFACG.........................MKFVYPS..LA...AVHHHHHH...............................
A0A1W4WHV5_AGRPL/40-149              ..................................PQYEQFLTDVWVGLVLTFMVLSCICCMCS..CLLYHKF..............QQWK----.................................................-RHIIQARNA-.--..........----ANVEAGSNYESE......SLPSYTVVSGLPTYDEALEQLKKMKE--.........................-------..--...--------klrtdsrvvdsnpqpctthvpsn........
A0A0T6AXE9_9SCAR/44-148              ..................................PEYEQFLADVWVGIVLTLMVLCCVCCMCS..CLLYHKF..............QQWK----.................................................----RSVEERR.--..........----REDLEAANAESE......SLPSYTIVSGLPSYEEALEQLKKVKEL-.........................-------..--...--------ssvssssskdqaaasatgp............
B4LII4_DROVI/152-260                 .................................e-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFLYHKF..............QQWK----.................................................----NSYRANH.GD..........ATIEVCRHCPPEYEVE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..IVpviKIFES---lnn............................
A0A2J7RF30_9NEOP/15-88               ......rlasgsnnrlpqspvlesrahsmaaggv-----------------------------..-------..............--------.................................................-----------.--..........----------TGGDVE......SLPSYTVVSGLPTYDEALEQMRQNTQCK.........................V------..--...--------edtkltmgstq....................
B4JZZ5_DROGR/145-252                 ...............................ddf----HVVSDIWIGVILTLLIVFVIFFICA..CFLYHKF..............QQWK----.................................................----NSYRANH.SD..........ASIEICRHCPPEYEVE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILRPA..LVpviKIFENA--nn.............................
A0A1W4W653_AGRPL/1-102               mwllllycvcgvvifscicyayliikaaviqarn-----------------------------..-------..............--------.................................................-----------.--..........---AANVEAGSNYESE......SLPSYTVVSGLPTYDEALEQLKKMKE--.........................-------..--...--------klrtdsrvvdsnpqpctthvpsnqivsrl..
B4MX67_DROWI/160-268                 .................................e-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWK----.................................................----NSYRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPS..VVpiiKIFEC---qgn............................
A0A2P8YEW8_BLAGE/12-69               .....................lesraqnveagga-----------------------------..-------..............--------.................................................-----------.--..........-----------PGDAE......SLPSYTIVSGLPTYDEALEQLRKLY---.........................-------..--...--------sltwgefgtslvsav................
A0A0Q9WKC9_DROVI/77-210              .................................y-SYRSTSTIVLMVAAWILLILGFVFCCCA.eCFG---V..............SVWRGKKQasitlsgae..............................sgaasatgneLSDLHADRANH.GD..........ATIEVCRHCPPEYEVE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..IVpviKIFES---lnn............................
D7FN65_ECTSI/79-153                  ..........................sssgssis------------GSLISVLVFALIFCCCG..CFLYAKF.............cDGWHGASA.................................................SASASSSASA-.-T..........AISNVNVA--------......----------------------------.........................-------..--...--------mpqmsygqqmsygqq................
A0A6G0YMA1_APHCR/99-143              ..............................myde----IVINDVWINAILSTLALSCAACVCL..CFLYCKI..............QQWK----.................................................-----------.--..........----------------......----------------------------.........................-------..--...--------iggkt..........................
B4GU92_DROPE/141-206                 .................................q-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWKNSSF.................................................PASCKTSLE--.--..........----------------......----------------------------.........................-------..--...--------sesdvgykwkpiq..................
B4QL66_DROSI/112-225                 .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNYR.................................................N---NANGST-.-Q.........cTIVDIEALKLHPDVED......PVPEYTLVSGLPSYEAALELLQKSPQSS.........................CLIVYPS..VF...NVFNKQE-r..............................
B4K1C0_DROGR/4-74                    ...............................cll-----------------------------..-------..............--------.................................................-----SDRANH.SD..........ASIEICRHCPPEYEVE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILRPA..LVpviKIFENA--nn.............................
T1GG69_MEGSC/81-192                  .................................t-DVQTVINYLWIGIVSSLIILSIIFIIFS..CYFYKKF..............KEWKRC--.................................................---NKDIRSQM.GE..........TRMNGGTSESDYYQIE......SPPCYTIASGLPTYDEALKH--THFSFE.........................RKSLEPT..FL...--------agvnvffrt......................
B4K0Z9_DROGR/12-112                  ....ihaandsysshgashhliscdasrllqqlp-----------------------------..-------..............--------.................................................---ASGSNNAA.TA..........AAAAAGGNEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFACG.........................MKFVYPS..LA...AVHHHHHH...............................
COMM2_AEDAE/97-214                   ..................................PTYERFIGDVWVGIVLTLMILSSIFCMCS..CFLYHKF..............RQWQ----.................................................----RSVLTAR.SQ..........TLSSMDLETPPPYDVE......SLPSYTIVSGLPSYNDAIEQLKQKQQQKspgg.................hlepVKLQRPS..VI...KLFESQSQ...............................
B4GU83_DROPE/114-227                 .................................l-EYDKFMNEVWIGIVFTLILISLVFCICS..CFLYHQF..............RTWKRNY-.................................................----RNNANNS.TQ.........cTIVDIEALKLHPDSDD......PVPEYTLVSGLPSYEAALELLHKAPKTS.........................CLIVYPS..VF...NVFNKHE-r..............................
B4LIH5_DROVI/111-224                 .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNY-.................................................---HSNANSSS.-Q.........cTIIDIEALKLQPDSED......PVPEYTLVSGLPSYEAALELLHKTPQSS.........................CLIVYPS..VF...NIFNKHE-r..............................
A0A182HCT8_AEDAL/96-139              ..................................PTYERFIGDVWVGIVLTLMILSSIFCMCS..CFLYHKF..............RQWQR---.................................................-----------.--..........----------------......----------------------------.........................-------..--...--------sgk............................
A0A0L0CJK0_LUCCU/135-261             .................................t-DMHSLINYLWVGVVTSLIVLTVIFVLFS..CYFYRKF..............REWKKCNKdir..........................................ahlnN-----DLYAG.GAamp...cvsaAAAAAANPEAAYYQME......SPPCYTIATGLPTYDEALHHNQQHFAFG.........................MKFIYPT..LA...AVHHQAS-n..............................
B4HIH5_DROSE/143-251                 .................................q-DFAHVVSDIWIGVILTLLIVFVIFFICA..CFVYHKF..............QQWK----.................................................----NSYRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--ILTPA..MVpiiKIFE----cnet...........................
B0XA56_CULQU/110-233                 ................................dp-------SYLWIGAVMVLLVLSGLFCVCS..CYLYYKY..............RRWQ----.................................................----KCVSITS.CHqp.....phgTLVG-DVESPPPYDPEttttaaTLPSYTVASGLPSYEDAVEHIYRQQQLQrqnp................ppaqpTSVHPPA..TV...KFFESRP-q..............................
A0A3B0KV47_DROGU/132-270             .................................a-DMLVLINYLWIGVIISLVVLSLVFILFS..CYFYRKF..............RTWKKCNKdistqihsan............................dsshgagshldSCDASRLLLHQ.SQ..........QPSAANSNEASFYEIE......SPPCYTIATGLPSYDEALHHQPHHFAYG.........................MKFVYPC..LA...PVHHHHHH...............................
A0A6I8W457_DROPS/1-149               ..................................-----------MVSAWTLLILGFVFCCCAecCGV----..............SVWRGKKRstiealngaerggeggeggagp....rsrpasggggvaastggsgsgsgHHQLSADRANH.SD..........PTIEICRRCPPDYEAE......SLPSYTIVSGLPTYDDALEEFRKAGI--.........................--LLTPS..VVpiiKIFE----cndn...........................
A0A3B0K669_DROGU/99-237              .................................a-DMLVLINYLWIGVIISLVVLSLVFILFS..CYFYRKF..............RTWKKCNKdistqihsan............................dsshgagshldSCDASRLLLHQ.SQ..........QPSAANSNEASFYEIE......SPPCYTIATGLPSYDEALHHQPHHFAYG.........................MKFVYPC..LA...PVHHHHHH...............................
B4HIJ3_DROSE/112-220                 .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWK----.................................................----RNYRNNA.NG..........STQ-SDALKLHPDVED......PVPEYTLVSGLPSYEAALELLQKSPPSS.........................CLIVYPS..VF...NVFNKQE-r..............................
A0A484BCA0_DRONA/130-279             .................................a-DMHAIVNYLWIGVVTSLVVLSLVFIMFS..CYFYRKF..............RTWKKCNKdiraqlhaasdsyssh.................gashhliscdasrllqQVPGNGNGNGS.GN..........GSSPGGANEAGFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHHH...............................
B4JZZ4_DROGR/74-160                  .................................y-SYRSTSTIVLMVTAWILLILGFVFCCCA.eCFG---V..............SVWRGKKRasislr....................................gaesgaaA----------.--..........----------------......----------------------------.........................-------..--...--------aaaaaatattiasvnelqagefssifsvrel
J9KFT9_ACYPI/52-161                  ..............................myde----IVINDVWINAILSTLALSCAACVCL..CFLYCKI..............QQWK----.................................................---HGIQRR-R.--..........-----NEKNSRKYDAD......SLPSYTIVTGLPTYDEAVERMN------.........................-------..--...--------gghnhggtssvrdnkppskhvsvsvvhird.
A0A6A4IKF8_APOLU/104-203             ................................da----RAVSDVWVSIVLILMTLSCIGCLCS..CLLYYKF..............QKWK----.................................................--VSDGS----.-E..........STNITEANSERRPSKE......GPPSYTVVTGLPTYEQAV----------.........................-------..--...--------vlcvtpihssgrtaantpihnp.........
B4MXW9_DROWI/137-252                 .................................l-EYDKFMNEVWIGIVFTLILISMIFCICS..CFLYHQF..............RTWKRNYH.................................................NTNASNSSTQC.--..........TIVDIEALKLHPDIED......PVPEYTLVSGLPTYEAALELLHKTPQSK.........................CLIVYPS..VF...NVFNQQQ-q..............................
A0A182Y5Y8_ANOST/2-80                ..........................snprgmep-----------------------------..-------..............--------.................................................------VLTAR.SQ..........TLSSMDIETPPPYDAE......SLPSYTIVSGLPSYQDAIEQLKQKQMKYy......................epVKVHRPS..VM...KLFESQ--dl.............................
COMM2_DROME/112-225                  .................................l-EYDKFMNEVWIGIVFTLILISMVFCICS..CFLYHQF..............RTWKRNYR.................................................N---NANGST-.-Q.........cTIVDIEALKLHPDVED......PVPEYTLVSGLPSYEAALELLQKSPQSS.........................CLIVYPS..VF...NVFNKQE-r..............................
B4GU80_DROPE/132-274                 .................................a-DMHVIINYLWIGVVSSLVVLSLVFILFS..CYFYRKF..............RTWKKCNKdmraqihaands........................ysshgagspghlvSCDASRLLLQQ.PQ..........QPSAGNNNEAAFYQIE......SPPCYTIATGLPSYDEALHHQPRHFAYG.........................MKFVYPS..LA...AVHHHHHH...............................
#=GC SS_cons                         .................................X-XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXX..............XXXXXXXXXXXXXXXXX..............................XXXXXXXXXXX----------.-XXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXX-----TTSS--XXXXXXXXX.........................XXXXXXX..XX...XXXXXXX-X..............................
#=GC seq_cons                        ...................................phtthhs.lWlGllhoLllluhlFhhCu..CahYppF..............ppW+.........................................................pt.ttst..p.............thpttp...hphE......ShPsYTlsoGLPoY--ALcp..+t...............................hhhPs..hh...tlap....t..............................
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