GenomeNet

Database: Pfam
Entry: Csa1
LinkDB: Csa1
Original site: Csa1 
#=GF ID   Csa1
#=GF AC   PF06023.15
#=GF DE   CRISPR-associated exonuclease Csa1
#=GF PI   DUF911;
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_8782 (release 9.0)
#=GF GA   27.00 27.00;
#=GF TC   27.40 27.10;
#=GF NC   26.70 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   22408157
#=GF RT   Characterization of the CRISPR/Cas subtype I-A system of the
#=GF RT   hyperthermophilic crenarchaeon Thermoproteus tenax.
#=GF RA   Plagens A, Tjaden B, Hagemann A, Randau L, Hensel R;
#=GF RL   J Bacteriol. 2012;194:2491-2500.
#=GF DR   INTERPRO; IPR009260;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   CRISPR (clustered regularly interspaced short palindromic
#=GF CC   repeats) elements and cas (CRISPR-associated) genes are
#=GF CC   widespread in Bacteria and Archaea. The CRISPR/Cas system
#=GF CC   operates as a defense mechanism against mobile genetic elements
#=GF CC   (i.e., viruses or plasmids). Csa1 is part of the archaeal
#=GF CC   subtype I-A system. Cas1 has not yet been enzymatically
#=GF CC   characterised [1].
#=GF SQ   69
#=GS F4B5P8_ACIHW/1-293       AC F4B5P8.1
#=GS A8ABK7_IGNH4/105-249     AC A8ABK7.1
#=GS K8DY73_9FIRM/1-303       AC K8DY73.1
#=GS B1I4M0_DESAP/7-311       AC B1I4M0.1
#=GS A0A2H5V0A7_9ARCH/6-307   AC A0A2H5V0A7.1
#=GS F4B6T2_ACIHW/1-283       AC F4B6T2.1
#=GS CSA1_SACS2/1-291         AC Q97YD4.1
#=GS C9R974_AMMDK/1-307       AC C9R974.1
#=GS A0A0F7FGX1_9CREN/4-310   AC A0A0F7FGX1.1
#=GS E1QQW1_VULDI/1-189       AC E1QQW1.1
#=GS A1HNE2_9FIRM/1-306       AC A1HNE2.1
#=GS Q9YCL7_AERPE/1-91        AC Q9YCL7.2
#=GS A2BKJ7_HYPBU/125-270     AC A2BKJ7.1
#=GS F6B8W8_DESCC/1-303       AC F6B8W8.1
#=GS G0EGJ8_PYRF1/4-289       AC G0EGJ8.1
#=GS Q8ZZL7_PYRAE/1-280       AC Q8ZZL7.1
#=GS A0A2H5V4I6_9ARCH/1-313   AC A0A2H5V4I6.1
#=GS A0A3N5AP42_9THEO/1-306   AC A0A3N5AP42.1
#=GS Q977B6_SULTO/1-288       AC Q977B6.1
#=GS K0ICJ6_NITGG/1-318       AC K0ICJ6.1
#=GS S5Z705_9CREN/14-115      AC S5Z705.1
#=GS Q97Y83_SACS2/1-281       AC Q97Y83.1
#=GS B8D4S8_DESA1/1-280       AC B8D4S8.1
#=GS H2C0Y0_9CREN/1-293       AC H2C0Y0.1
#=GS D5U1T3_THEAM/41-321      AC D5U1T3.1
#=GS A0A2H5UZT8_9ARCH/3-299   AC A0A2H5UZT8.1
#=GS A0A2T9WWH0_9CREN/9-266   AC A0A2T9WWH0.1
#=GS K4LGE4_THEPS/1-307       AC K4LGE4.1
#=GS A0A4R1BEZ2_9ACTN/1-284   AC A0A4R1BEZ2.1
#=GS A0A2V3JM66_9EURY/2-257   AC A0A2V3JM66.1
#=GS E0STX3_IGNAA/31-127      AC E0STX3.1
#=GS Q8ZZU0_PYRAE/1-286       AC Q8ZZU0.1
#=GS B0TFX6_HELMI/1-310       AC B0TFX6.1
#=GS A0A510DYE0_9CREN/1-287   AC A0A510DYE0.1
#=GS A0A5Q2N509_9FIRM/1-307   AC A0A5Q2N509.1
#=GS F4BVL1_METSG/1-313       AC F4BVL1.1
#=GS B1L401_KORCO/2-309       AC B1L401.1
#=GS A0A031LIY4_9CREN/2-295   AC A0A031LIY4.1
#=GS E0STX3_IGNAA/129-297     AC E0STX3.1
#=GS H2C4W1_9CREN/12-295      AC H2C4W1.1
#=GS D3RZS6_FERPA/1-310       AC D3RZS6.1
#=GS D9PZC8_ACIS3/1-262       AC D9PZC8.1
#=GS L0K8Q1_HALHC/1-305       AC L0K8Q1.1
#=GS A0A023X6Y1_9ACTN/1-284   AC A0A023X6Y1.1
#=GS A2BKJ7_HYPBU/2-128       AC A2BKJ7.1
#=GS Q9YCL7_AERPE/84-260      AC Q9YCL7.2
#=GS A0A6N7IM04_9FIRM/1-309   AC A0A6N7IM04.1
#=GS E1QU80_VULDI/3-265       AC E1QU80.1
#=GS A0A4Y7RV06_9FIRM/1-306   AC A0A4Y7RV06.1
#=GS A0A4R8HFU4_9FIRM/1-305   AC A0A4R8HFU4.1
#=GS W7KGY0_9CREN/1-268       AC W7KGY0.1
#=GS A0A2R4ZSS2_9CREN/7-298   AC A0A2R4ZSS2.1
#=GS A0A0M2U345_9FIRM/1-306   AC A0A0M2U345.1
#=GS A0A348B575_9CREN/1-300   AC A0A348B575.1
#=GS A0A4R2RGP8_9FIRM/1-312   AC A0A4R2RGP8.1
#=GS A0A2U9IJ08_9CREN/1-284   AC A0A2U9IJ08.1
#=GS A0A0U2U6Q3_9CREN/4-108   AC A0A0U2U6Q3.1
#=GS O28400_ARCFU/1-281       AC O28400.1
#=GS A0A2H5UZ86_9ARCH/2-70    AC A0A2H5UZ86.1
#=GS A8ABK7_IGNH4/16-105      AC A8ABK7.1
#=GS A3DLB8_STAMF/1-310       AC A3DLB8.1
#=GS Q96X76_SULTO/1-279       AC Q96X76.1
#=GS I3TFC8_THEC1/4-283       AC I3TFC8.1
#=GS CSA1_THETK/1-278         AC G4RJY8.1
#=GS H9ZZA3_FERFK/2-297       AC H9ZZA3.1
#=GS E0SSI5_IGNAA/1-240       AC E0SSI5.1
#=GS S5ZDL3_9CREN/1-117       AC S5ZDL3.1
#=GS A4YFV5_METS5/1-272       AC A4YFV5.1
#=GS A0A0U2U6Q3_9CREN/90-237  AC A0A0U2U6Q3.1
F4B5P8_ACIHW/1-293                  .........................................................MFFTSSDI..LLL.sRRIKKS--PRAIDEELRGWNWNEPPIYSQHF.SQTSVSELI--YCSTLRNLYLR.Q.KGYKVGE..ES.S.LIK....KGRAIHDTYSTAISTIKRLLYSS.P.Q.ID....GNK....L.....K........TL...M...T..DEFYs.........flKKYEDQAD.................YVKTLWDYI..TN..IYS..AELDRVR....SKFFNLTED...SLVSSV......VP..F.Y.VEYPVD.GSLVGLSSSLRIDAFVPFIP.......L.I.A..EMK.T......GK.....YKY.....SHELQLAGYALAFESQY.EIPIDFGYLCYV..NVdEKEV...KSNCKLI....QISNSLR.SEFLDKRDKALEIMDNVID...P.G..IA.N...DCE.KE..CPYYKVCH--ps.........................
A8ABK7_IGNH4/105-249                ...............................................pllkrvyeea--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....----KVRKA...AAEEEG......IP..V.E.VEPEIP.GHSVGLSSALKPDFLVGFIP.......-.-.V..EVV.Y......GN.....GLE.....RKKLAVTGYALALESWI.GHPVEVGIVVSV..T-.--DK...KTYWNVV....RIHEGLR.RRFLEVRDEVARILGEKED...P.G..AP.E...ECP.KA..CPFAEVCK--r..........................
K8DY73_9FIRM/1-303                  ...............................................myflsdeekk--------..HLL..KGYLPRSRQTYIVDELRGWNWHQPPLLPPYE.LKLGAYEIANAYCPSYRDLYLR.R.VQKVRSQ..PN.L.AML....RGAFLHDILVKEIIAAKKIIYKT.G.I.AS....YKT....I....fK........QL...E...K..REPY............KVPDNFQLndkek.......aclerEAEIIVKFE..RQ..RLT..SRIHDVL....VKQPYIGED...SLVNIA......VP..L.V.VEQKLD.GSFLGMSAHLSIDAYTFSEP.......M.I.L..DLK.F......GE.....KKS.....FHRLQTTAYALAMEAIY.EFPVNLGCIVYA..KI.KDDR..lFIEKDIH....IIDEELR.QWFIEERDEKMRLVEEEID...P.G..V-.K...DCL.DT..CPYYQFCH--...........................
B1I4M0_DESAP/7-311                  ..................................................yflteee------KK..HLL..KGLLPRSRELGIAEELRGWNWPAPPLQPVYD.TVLALYEVANSYCPTNRDLYLR.R.VRRVFPA..PS.A.AMV....QGRVLHAALVHVLVSAKRLIYSV.G.V.AQ....YQT....I.....CrelqelgpVN...V...E..SELQ...........aLAPEDAADl..............krKVAIVTEFE..KA..RII..SRIQEIL....FKQPYIGED...SLAVLA......IP..V.I.VEQKLD.GSFLGLSPNLSTDAFTVCEP.......M.I.V..DLK.F......GE.....RRD.....FHRLTTTGYALVMESLY.EFPVNIGCLVYG..SF.RGDR..lIINKDLH....IIDDELR.QWFIESRDEKARMVYEEID...P.G..FP.A...ECY.QG..CHCYAACHG-...........................
A0A2H5V0A7_9ARCH/6-307              ..................................................mvyflga--------..EEM..REVEREASKTVIDESLRGWSYNSSPVRPPYD.IPLPVSVIANRYCRCGRDVYLS.Y.VLRQAGK..PP.T.EAR....TGHLYHEIISSIVEEAKRFIYNY.G.TaPP....IEL....Y.....Q........YLd.tM...G..ETTI............QGLADKLKlpted.......slhvrNARKLWMYM..SL..EIS..HSLNTVL....SRGVGVSLD...TLVSAT......IP..F.V.VNYLVN.GRPVGLSERLQADA-LGAMS.......L.V.L..DLK.T......GP.....PMD.....FHKLTTTGYALALESSL.SQPVNVGCIVYL..SF.RDESptpIVIRRIH....AIDESLR.MEFLEERDRKQRIVAEGID...P.A..KP.S...ICD.PN..CMYLN-----l..........................
F4B6T2_ACIHW/1-283                  ...................................................mynvrs-----QII..RQV..RRLHSYRASDPIEEELRGWNYHMPPIKPRRY.LGLSMSDVAYRYCDTKRDVYLR.R.VLKVQGE..QR.S.ALV....LGQSVHEVIASVSNEIVKLLSLG.Y.K.PW....AAI....E.....A........IF...R..kA..NKVS...........nLCPQQFFK.................FCEEVYKAF..AL..DLI..SDFSD--....---------...STSF--......LP..I.I.SEFRVD.GTPLGLSSKLSVDA-ITQLS.......L.V.V..EIK.V......AS.....TQE.....FHKLALAGYALALESAL.ELPIDFGSLIYV.nGI.NKNT..pEFKYEVY....YISPDLR.KEFIDARDEVIDMVSEGRD...P.G..MP.T...ACC.PS..CPFLNYCN--kg.........................
CSA1_SACS2/1-291                    .........................................................MFFTHSDM..LLL.sKRIKKL--PKNVDEELRGWNWSEPPVYTRSL.SQVSISEMV--YCSTLRNVYLK.-.VKGFRGE..IG.R.QIL....QGSLIHTIYAIGIEAIKRFIYSR.E.S.ID....GST....L.....R........TL...M...G..DEFY............SLLKDLREee.............giYAKVLWDHI..TN..IYS..AELDRVR....SKFTNLTRD...SLVSQV......VP..F.Y.VEFPVD.GSLLGLT-NLRVDAFIPHLP.......L.I.A..EMK.T......GK.....YRY.....THELSLAGYALAIESQY.EIPIDFGYLCYV.tVT.EKEV...KNNCKLI....PISDSLR.SEFLDMRDKAQDIMDKGVD...P.G..IA.K...DCE.SD..CMFYKVCH--p..........................
C9R974_AMMDK/1-307                  .....................................................myff---TDEEK..KHL.lRYHLPRAREQGVAEELRGWNWHQPPLEPVYRdVVLALYEVANSYCPTGRDVYLR.R.VQQKRGR..PN.L.AMI....QGIIFHAVVADVIVAAKRAIYSE.G.V.AN....YRAi..vE.....R........IQ...N...H..PPIPl..........dEWAEQLSKdqld.........dtlaKAEILATFE..KT..RVL..ARLQEIL....TKQPYIGED...SLVSLA......LP..I.V.VEQKLD.GSFLGLSPNLSTDAFVFWEP.......M.V.I..DIK.F......DR.....QRD.....FHRLTTTGYALVMEALY.EFPVNLGCIVYG..EF.RGDR..lIVKKDIH....IISDELR.QWFIEARDEKARLVAEEID...P.G..K-.G...ECY.EE..CPYFHICW--ge.........................
A0A0F7FGX1_9CREN/4-310              ........................................................l-FPIIEDI..NSL.yRDFRRM-PPVEVSEELRGWSYGQGVVAPPGG.PLLGVSDITGGFCDRGRDVYLR.Y.VKRVQPR..DN.Y.LLQ....RGRLIHETWTRTIVEVKRSIYNH.G.L.DA....SIQ....E.....L........AN...T...A..STLK...........eKLKAEFNAkhslvp.....eeertwLVDRIINEG..FS..TYA..SSLERQL....SRSRFLEID...GLVAAT......VP..L.L.TEYPLN.GEKIGLSRALRIDALIP-PG.......L.I.L..ELK.T......RH.....PRR.....EFELALVGYALAFESEY.EIPIDRGLLMYV..EV.DPPKrrlYVRPRII....ALGDALR.SEFVERRDKLLELILYDED...P.G..VS.S...NCP.SE..CPYIHYCRG-g..........................
E1QQW1_VULDI/1-189                  ......................................................mlg--------..RLL..DRVKVF-GVGDLPVELRGWSQEVREVSLE--.YLPTVSEAF-SPCPTHRDVYVR.R.VLRLQPR..IN.D.SLS....IGRALHELFLTPLRLVNRVGAGD.V.-.--....IEE....L.....S........NL...K...A..QLLS............DLTKDLVD.................FGKVVFEAS..SR..ILM..DLVYD--....---------...---GYP......IP..I.A.VEPSLE.GTVIGFSDVIKPDLVIGSLP.......VeV.V..VSE.N......PD.....YLA.....RKELALA----------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------dvv........................
A1HNE2_9FIRM/1-306                  ...............................................myfltdderk--------..MFL..KKMLPKARRLDIDEELRGWNWHQAPLEPVYE.ERLAVYEVSSGYCPTSRDLYLR.R.VLKNKLK..PN.F.FMI....SGRVFHQIIVDVMENAKKQIYYH.G.T.YA....PEK....L.....M........AA...L...R..QPIAikw.....pddlN------Llsaeq......sqdiktKGNFLRDYE..QS..RIA..ARIGEIL....TQQPYIGAD...SLAHLA......IP..L.V.CENKLD.GRFLGLSQYLSADALILSEP.......M.I.I..DLK.F......GT.....PQK.....YHRLSTTGYALAMEALY.EVPVNLGCIVYG..EFrNGRL...IVTKDMH....LIDDELR.QWFIESRDNKMRMICEEID...P.G..IA.E...GCY.EY..CPGYEFCH--q..........................
Q9YCL7_AERPE/1-91                   ......................................................mfp--------..RGL..WDLVRSSAGDGVYAELRGWKWNV--VGPRYA.ARPTLSDVT-GVCPVGRDTYLR.R.VLNTRVN..-G.G.LLR....LGALVHEAFLLPFKAHRV-----.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------gday.......................
A2BKJ7_HYPBU/125-270                .................................................ailalqsr--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...--VDGD......IP..L.R.VEPPIP.GAPVGLSDTVRPDLLVGFIPv.....eV.T.A..AGP.W......GT.....YGS.....KKELQLAGYALAIEAWT.GIPVDYGVVVYV.tRR.SDEP...RPEWRVV....VIDDALR.RSFLRERDEVAMIVENRVD...P.G..PAgE...GCP.SW..CPFRG-----vegcp......................
F6B8W8_DESCC/1-303                  ................................................myflsdeek-------K..HLL..KNYLPRSRQADTAEELRGWNWHQPPLLPPYE.TKLGAYEIAGAYCPSNRDLYLR.R.VQKIKSL..PS.L.AMI....RGYFLHDVLVKELSRAKKIIYHR.G.V.PG....YKE....I....fN........DL...E...Q..GQDY............KLPDQFQVnkkdk.......lylekEADIIAKFE..RQ..RLA..AKIHDVL....VKQPYIGED...SLVNLA......VP..V.V.LEQKLD.GSFLGMSSHLSVDAYTFSEP.......M.V.M..DLK.F......GE.....KRK.....FHRLQTTAYALAMEAVY.EFPVNLGCIVYA..KI.KDDR..lIIEKDIH....IIDDELR.QWFIEERDEKLRMIEEEID...P.G..V-.K...ECP.DS..CHIRQLC---y..........................
G0EGJ8_PYRF1/4-289                  ....................................................llaas-----SLA..RAL..RKLHLLRAADPVEERYRGWSWHSSPVKPRYF.VGLGVSEVAYRYCPTRRDLWLR.R.VRGLRGQ..PT.E.AML....KGRIVHEAFRLAARDLSRLVLGE.G.K.ST....EDA....V.....-........--...-...-..---A............ELVGGARE.................RASVILESA..GI..EGD..GDGIAVF....AARVYKKMV...FAWAQWmeetgaPP..W.I.TEYEVD.GGLLGLSRRLRVDA--LAPG.......L.V.V..EVK.Y......GR.....WSR.....DYPVALAGYAMALEASL.EIPFDYGLVILV..NG.-DGS...RLTLEPV....YIGNEER.AEFLTARDEAAEIVVSQVD...P.G..RP.P...RCP.DQ..CPMRLVCA--p..........................
Q8ZZL7_PYRAE/1-280                  .........................................................MLTLQEIA..RLL..RRAKITWGPVEISPEYRGWNYDKPPVKPPAY.LGLALSDFAYGYCPTGRNIYLK.Y.VLGERGA..AV.K.ALV....EGQALHQALFKALEDYKKYAYSG.H.P.MS....PSF....E.....-........--...-...-..----............GVPEDVRP.................KAEALYKYV..AT..RLL..GEHSYVS....AARLARSRD...SAVFYT......AP..I.A.TQVAVD.GSPLGMS-YVVADG--VALG.......A.V.I..EFK.F......GP.....AQN.....V-DAALAGYAMAIEADW.GVPIDYGIHVQI..TV.NSTV...EYKATAY....PLGDSAR.TKFLELRDEAIDIVIAGRD...P.G..VA.P...DCP.KT..CPFYHICHA-dr.........................
A0A2H5V4I6_9ARCH/1-313              ..................................................mfflrre-------EfeRRL..RALRDQVDAAMVSPELRGWNSSRPPVKPLGR.HLLSVSELASRYCPTMRDVYLR.R.IARISPP..PS.F.KMF....RGLVYHFIINQLTTRSKRYIFER.G.KiPG....PEL....F.....K........LL...L...I..DEPV............AVESAVRDastkvqvdedevrsltlLASRLYRYL..AL..QVA..SGVDLTQ....SKFPHVDVD...SLVNES......IP..A.V.SEMKVD.GSLVGLSRELSVDIYT-PYN.......T.V.I..DIK.T......GD.....IRS.....FHRYVGAGYALAIESDK.GVEVDFGVTIYI..SV.QPSApapEVKADYY....LIGDELR.REFLELRDEAQLLIEKGKD...P.G..MP.V...KCP.EF..CPYYTVCN--r..........................
A0A3N5AP42_9THEO/1-306              .....................................................myff---TDEEK..KHL.lRYHLPRARERGVAEELRGWNWHQPPLEPVYRdVVLALYEVANAYCPTGRDVFLR.R.VQREKGR..PN.L.AML....QGAIFHAVVADVIVAAKRAIYGE.G.V.AN....YRT....I.....V........ER...V...Q..NHPVlpld...awaeqL-----TPeela.........dtasKVEILAAFE..KT..RVL..ARLQEIL....TKQPYIGED...SLVSLA......LP..V.V.VEQKLD.GSFLGLSPNLSTDACVFWEP.......M.V.L..DLK.F......DK.....PRD.....FHRLTTTGYALVMEALY.EFPVNLGCIVYG..EF.RGDR..lIVKKDIH....IISDELR.QWFIETRDEKARLVAEEID...P.G..T-.G...DCY.EG..CPYHHVC---fg.........................
Q977B6_SULTO/1-288                  .........................................................MFFTLSEI..QLL.sKRMKGF--PRAISEELRGWHWNEPPLYPSSN.TLLSVSDLTNGLCDSGRYVYLK.-.HKGIVPK..VE.A.KI-....-GNTIHTTYATAIETIKRLIYEH.E.D.LD....SVK....L.....R........TL...M...T..DEFY............NLKVEVIE.................VAKILWDHI..VS..IYS..AELEKAR....SK-PFLRKD...SLASLV......IP..F.H.VEYPVD.GSLVGLQSALRVDAFIPILP.......L.I.A..EMK.T......GS.....YKR.....DHELALAGYALAFESQY.EIPVDFGYLCYV.nVI.EGKI...HNNCRLI....VISDTLR.QEFVEVRDRALRAIDDDVD...P.G..LA.K...KCS.AD..CPFLPHCKG-g..........................
K0ICJ6_NITGG/1-318                  ................................................myflsgedr--------..RRL.fKGIVSRGRTMTVDESLRGWNWDKPPIEPPYDtIKLGVYEVASQYCQSGRDVFVR.R.IDGIKGV..PS.K.DMV....RGLVYHYAVADEISVAKAYMYKQ.G.V.LGaaglYEH....L.....K........AK...S...E..ERFAsym.....lthgE---YFREaaftea....dieevkmNLDKLWGYE..AS..QMA..ASIKAIL....SKQPRIGID...ALVHTA......IP..V.I.VEQKID.GSALGLSTHLSVDA-FSFDS.......I.I.L..DLK.T......GE.....EKE.....FHKLSTTGYALVYESIF.EYPINVGCVVYV..NF.SNNSpvpIIKRVPH....LIDETLR.REFLEARDLRMKMIYDRRD...P.G..LP.R...KCY.AK..CQYLRHCG--vg.........................
S5Z705_9CREN/14-115                 .................................................yfskrdly--------..ASL..RRFHRARSQDPVEEEYRGWNWDKPPLRPRAY.LGLGVSEVAYRYCPTMRDVYLR.-.RMGVEGE..KN.Q.WLA....NGELVHRVFQMVSEEVRREL---.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------algrs......................
Q97Y83_SACS2/1-281                  ......................................................mrs-----QIV..RQL..RRLHSYRASDPIEEELRGWNYYMPPIKPRRY.LGLSISDVAYKYCETKRDVYLR.K.VLKIQGE..QR.T.PLL....LGQAIHEIVRNVSNEVVKLLSSG.Y.K.PW....SVL....E.....T........LF...R...N..NKIVr..........sLCPPQFIK.................YCEEVYKAY..AL..DLL..SDFSD--....---------...STSF--......IP..V.I.SEFKVD.GSPLGLSSRLSVDA-IMQLS.......L.V.V..EMK.V......GS.....VQE.....FHRLALAGYGMALESAL.ELPIDFGALIYV.nGI.NTSS..pEFKVEVF....YVSPDMR.KEFLDARDEVIDMISQEKD...P.G..MP.V...SCS.PS..CPFLNYCNN-nk.........................
B8D4S8_DESA1/1-280                  ........................................................m-------L..RLV..RRIYSWSRADPVDEELRGWNWDKPPLKPRAY.LDLGVWEVSSKYCGTRRDLWLR.R.KMGVVVE..PS.E.SMA....KGKMVHEAITTALREAGRYLSNG.L.E.VW....SAY....E.....A........AK...-...-..EKWRri........dtGGSRENAR.................LVEKIYKST..LL..SIL..GEAAYE-....-------EA...LYGSRR......PP..LaI.SEYRVD.GSNLGLAPNLSADL-VAEGG.......V.I.L..DIK.Y......GA.....PRE.....FHKLSLTGYALALESEY.EVPYDYGILIYI.qGY.LESL...KINIKPI....YINSYLR.RYFIEERDEIIDMLIENRE...P.P..RD.S...ACN.PS..CPFYKVCN--k..........................
H2C0Y0_9CREN/1-293                  .........................................................MIFTLDQI..ALY.aKRARST--PRSISEELRGWRWNEPPVFPSSS.RTLGVSDVL-STCPTGRDVFLR.Y.VKWVRSG..TE.-.--P....RGSLIHETYASAVETVKRFIYEG.V.S.DG....NQ-....L.....R........SS...M...L..EEFY............TFMKRLDKyrdf........pqyleVGRAMWDYV..SS..VYS..SELDRAV....QRSPFLARD...SLASMI......VP..F.F.VEYPVD.GSLVGLN-QVRVDAFIPQIP.......M.V.A..EMK.T......GV.....RKK.....-YELSLAGYALAYESNF.ETPVDFGLLCYV..KY.EGRI...NVRCDFK....VISDRMR.EEFLEERDKRLEILDKEID...P.G..LP.N...FCD.PH..CPFLSVCGG-k..........................
D5U1T3_THEAM/41-321                 ....................................................lilrr-----VMF..RSI..RRLYELARADPVDPELRGWSWDRLPLKPRAY.LNLGVSEIASKYCETRRDIWLR.R.KTGARAE..PT.E.PIL....TGRLIHDAISLALKETAKLLINN.T.E.PY....TAY....Q.....I........LS...-...-..EKWRk..........lNPPKGYEK.................TVEKTYKAT..LI..TIL..GEAMY--....EK---L---...-VNETP......QP..VaY.SEYRVD.GTPLGMSQNLSVDV--ISDS.......V.I.I..DFK.T......GA.....PRD.....FHKLSITGYALALEAAY.ETPRDYGLLIYI..NN.PEDP...RITYKPV....YISNTLR.RLFIEERDNIIDMLLEDAE...P.P..KD.L...NCQ.PT..CPLHGACN--k..........................
A0A2H5UZT8_9ARCH/3-299              ..............................................fysyddllris--------..---..KTIQEM--PCDVSDELRGWRWSDPPLLPVYS.VKINASDLS-FSCGTGRLAFLR.H.SLRVGEK..AG.E.GLR....FGAFVHQVISAATANAKAIMYCS.K.P.SN....GVE....F.....F........EI...M...S..RTMYscv......qvdGLTEDYVN.................ALNTLWSRA..AL..TYS..SAYDRIL....ETSKYLSVD...GLVGRV......VP..W.I.CEFPVD.GRLLGLSRAIRLDA-LAPPA.......L.I.V..EFK.T......RK.....PSR.....EFEVALTGYALCFESQY.KIPVNYAVILYI..EF.NHSKtsfKVYENIV....RIDDEVR.LRFVEKRDLYAQIASAKVD...P.G..LP.V...ECD.AY..CPFLRVCR--se.........................
A0A2T9WWH0_9CREN/9-266              .................................................rvlglgdl--------..---..------------PVEVRGWSREVSEVY--YE.YLPTVSETF-TPCPTHRDAYLR.R.VVGVKAP..VN.N.SLG....VGRVLHDAFLTPFKAVYRLDAGS.L.V.E-....--G....L.....A........RA...K...G..ELLG............SITNDLVG.................AASVVFDYG..AR..FAM..-D-----....-----LKLE...S---FP......LP..V.A.VEPELS.GSLVGFSDVIKPDLVLGMIP.......VeV.V..VSD.N......QD.....YIA.....RKEEALAVYAMALEAMW.SNPVNYGILVII..NP.RTA-...SLITRQV....VLTDDVR.RAAIRERDETARIVSRKDD...P.G..SG.G...RCP.QS..CPFYDYCM--ggg........................
K4LGE4_THEPS/1-307                  ..............................................mmyflsdderk--------..QLL..RYYLPKARELGVVDELRGWNWHQPPLEPVYG.SVLALYEVAGKYCPSGRDVFLR.R.VQGIKGE..PN.S.AMI....QGMVLHEVLADLLVTAKRAIYLH.G.T.EK....YRAiceeL.....E........KYipeK...T..SHFAgl........tdSEAADLSR.................KVEILCSFE..KA..RVL..SRLQEVL....TRYPYIGED...SLANLT......IP..V.V.VEQKLN.GAFLGLSGNLSTDAFIFYEP.......M.I.L..DLK.F......GE.....PRD.....FHRLGTTGYALVMEAIY.EFPVNLGCIIYG..EF.RGDR..lIVKRDIH....IISDELR.QWFIEERDEKARFVTEEID...P.G..LA.E...DCP.AT..CPFYHVCC--ae.........................
A0A4R1BEZ2_9ACTN/1-284              ...................................................mfmpta----EEKK..RLL..RGTIPRARKLGVDDTLRGWSWSAPPLLSPYE.VPLGLSEVANAYCATGRDIYAR.R.VLGAETE..PN.E.KMI....LGSALHSTLREWTVHAKRKLYES.G.A.ED....IER....A.....-........-V...R...-..-EIR............AFPEPDLP.................EARSLVAYE..AD..AIE..FRLREAI....SQFPRIGTD...ALVAQV......LP..V.T.LGQMLD.GAFLGLSRRLSTDLLNLGEP.......A.V.L..NII.F.....nDE.....KRS.....FHPLTLAGYALVLEAVY.EFPVDVGVTVYA..SFrNGRL...QIEREFA....VLGDELR.MEFIEVRDEKQRMVADELD...P.G..PC.E...ECE.AW..C---------s..........................
A0A2V3JM66_9EURY/2-257              .....................................................sdtv--------..---..-------------------------------.---LVSDIV-TYLRCPRLVYFA.N.LLNNREP..VE.R.DVN....ARYLAHLLSKELALTYHRAAAST.S.E.DV....AEV....L.....Q........TE...L...-..DRIV...........nELPMIYRAel.............agVDHSVIRDA..AE..SIDtgAIGLQII....DVIRKTGRD...ELLARI......TP..C.A.VEYAIY.SDALGLA--GSPDKLVRVGD.......C.V.LpyMIR.T......GNtpengVWK.....PDRMQITAYAMLVEERF.EQVVEYGFVEYA..RF.----...-FEIRKV....VIRSGDR.RRVLELRNRV-RMIKGGRM...P.D..RA.Q...GAPcEL..CVFEEDCV--ak.........................
E0STX3_IGNAA/31-127                 ................................................fvrwfdmlp--------..RWV..WDYVRATAGDGMYAEVRGWRFDV--VGSRFR.ARPSISEVA-SPCPTKRDVYLR.R.VLHTYVD..-S.Q.VLR....LGRAVHEVFLLPFR---------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------yrgrdiew...................
Q8ZZU0_PYRAE/1-286                  .........................................................MFREFRMV..RGL..--------RVEVGEELRGWRWGEPPVQPPPLgVRLSVSDIVGGGCESRRDLYLK.R.VLGVRAE..PN.G.GMK....FGAYIHEVFKRSLAELRSLIEGG.A.V.KG....WEL....V.....Q........SF...N...A..EAIAr..........eAAIAAEAEa..............dpRGVELARYL..AI..QVA..ARVDEIA....SR-SSADSL...SIAARA......VP..V.L.AEYVID.GRPLGLT-LVRADA--LYYN.......V.V.V..EIK.V......GS.....YSE.....RHALALAGYALAIEADE.EVPVDAGLLISV..AF.NGGV...KLRAYPV....AIGEGLR.REFLEERNRLMELVASGSD...P.G..LS.P...KCD.DK..CPLWRHCHG-g..........................
B0TFX6_HELMI/1-310                  ...............................................myflsdeerk--------..KLL..HYYLPKARREGVAEELRGWNWSQPPLSPVYD.CPLGVFEVASGYCSSSRDVYLR.R.VEGARSK..PN.G.AMF....QGSLLHGLAARFIVATKGLIYQE.G.V.DG....YRE...iL.....R........KL...Q...E..MTLSelldeglvfelaSLA----Eadre.........elerKSRLLLEFE..RG..RLI..ARLQEAL....VKQPYIGED...ALTALA......VP..V.V.VEQKLD.GSFLGLSAHLSADAYNIGQP.......M.I.V..EVK.F......GE.....PRD.....FHRLATAGYALVMEAVY.EHPVDVGCLVCV..TF.KGDR..vIIRRDIH....LIDDELR.QWFVEARDEKARMVYEEID...P.G..LA.K...DCP.QS..CPFANRC---s..........................
A0A510DYE0_9CREN/1-287              .........................................................MFFTLSDV..MLL.sRRTRST--PRSISEELRGWNWSEPPVYPPST.MTLGVSDLTNGLCPTGRFAFLK.-.YTGKKVE..-V.K.PL-....PGASVHEVYAKGIETVKRLIYE-.E.D.LN....GAR....L.....R........TL...M...E..DEFY............SLKVEDLT.................LAKAIWDRV..VN..TYS..AELDKAK....GRSPYFSRD...SLASMV......VP..F.S.VEFPLD.GTLVGLHNGVRADAFIPHVP.......M.I.A..EMK.T......GK.....PRR.....QHELALTGYALAYESMF.EYPMDFGYLCYV..QV.KEGR..vFDSCRLV....QVGDYLR.DEFLQMRDKVMESIENGVE...P.E..KP.K...RCD.QD..CPFLKVCN--p..........................
A0A5Q2N509_9FIRM/1-307              .................................................mifftdee------RR..RVL.fQELQRL-KEQAVDEELYGWNCFRKPLCPFYN.TFSVESETLTERHESYEQVSST.G.NSSAWEE..MT.V.TINpvgiAEKVYYDVVVNFLSAVKLLIYQQ.P.G.KA....PVD....V.....L........NE...I...Q..KEIEklq......vlgLLSKDVLDllpiypk..eqdqrvlaNAERLLNYE..RR..RIM..VRIEEVL....AHHRNISMD...FLALKT......VP..L.N.LQMSLQ.GHLIGLVAGLKADVI-RITElg...ssA.V.V..ILK.VlknhrdDR.....FDEapisfSHRMLTTAFALALESNF.YNPVHVGVIVYL.sFV.GQDI...FVDKDIH....LIDNDLR.ELFIEWRDG----------...-.-..--.-...---.--..----------swn........................
F4BVL1_METSG/1-313                  ...................................................myffse-----EER..KYL.lKKLIPSTRERGIAEDLRGWNWHCSELSPPHD.ILMPVWEVSDRYCETGRDTYLR.H.VQKVSVP..AS.E.EMV....AGRIYHQAMAELYPTAKRLIYKEgM.S.IC....AEL....P.....G........IL...MerlD..DAIV............EANEQLSQtkfspsa..eagqsvsdNLRKLWSFE..VS..RIV..SSIFAYL....AKYKYLSDD...SLINHA......LP..F.V.VEHKLD.GKYLGLSRNLSADAINMGGM.......L.I.C..DLK.T......GQ.....KRD.....FHRLSATGYALVYESLY.EVPINIGCTVYL..SF.PKNHptpHIERDFF....IISDEVR.QWFIEERDSKQDLIFYERD...P.G..RC.P...N-P.GS..CRYREFC---f..........................
B1L401_KORCO/2-309                  ...................................................yyvdpv------EV..KKL.sRDLLPASRERPVDERLRGWNWFQSPLRPYSSeVPLGVWEIASSICPTGRDVWIRhK.VLRRSVP..TT.P.QIA....KGIVVHRLVSSMFLKAKKMVYMG.K.Y.EL....RDD....L.....-........IT...E...S..EGIV...........eRELENMRKyvklpd.....eeglrgFCRRIARWE..AT..RIE..GKVMEVR....AKYPFLNEE...SLVQIA......FP..V.A.TELAID.GSLLGLSQYLRADAAWIFGG.......I.L.F..DVK.T......DR.....KED.....WHRIQLAGYALAFESFF.EMPVDIGCVVYV.sEV.PEGL...RVFRDFF....LITDDLR.SRFLERRDELQMMLIREDE...P.K..RA.E...RCP.KY..CLFSDMCG--vv.........................
A0A031LIY4_9CREN/2-295              ....................................................iiyak--------..---..-RAKNT--PRAISEELRGWKWSDPPVLPPSS.SFIGVSDITGGLCPNGRIIYLR.Y.VEGVREP..SS.P.ELG....RGSIIHSAYSKGIENVKKLILDG.E.T.RG....-DR....I.....R........TA...M...A..DDLP............ILLKEISRfsnv........pnyqeVAKLIWNHV..SD..VYS..VEVDKVR....GKSPFLSRD...SLVSLV......VP..F.Y.VEFPID.GSLLGLSSNLRADAFIPQIP.......I.I.A..EMK.T......RK.....PKE.....VYSLTLAGYALAYESVY.EVPIDFGLLCYV..RV.DEQSsivQPKCDFK....VINDRLR.QDFLEERDRRLEIKERGVD...P.G..LP.K...YCE.AD..CPFLTTCGG-r..........................
E0STX3_IGNAA/129-297                .....................................ygmfrrslkdyadlrgywka--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-----FE....SVFRKSLAL...SMIAEEe....qMP..I.S.VEPYIP.GGAIGLSDFVRPDLMVGFMP.......I.D.I..TLS.L.....gGN.....SLE.....RKELALAGYALAIEAWS.GNPVDIGITIGI..SI.NSDV...RFQWRVV....RIDDSLR.RRFIEARDDVARIIEYGED...P.G..KP.S...QCL.KM..CPFREVCG--v..........................
H2C4W1_9CREN/12-295                 .........................................................MLSQAEMF..RSL..RKLHSWRSSDPVPEELRGWSYHRPPVRPRSY.LGLSMHEVAYLYCPTKRDVYLR.R.IMKVKGD..WD.KpHIQ....LGSLVHKVVGRASRDVALVALSG.Q.D.PV....EAF....S.....S........FN...P...-..---S............LECGEMEE.................YCRKLYKFL..TL..TWL..ADTARSR....AV-----YG...GEALGL......FP..W.V.SEIRVD.GSLLGLSNKLSIDA-LGS-L.......A.L.V..EVK.T......GK.....RED.....FHKVGLTGYALAVESSL.EVPVDFGFLVYFngVG.KGEV...EVQVDPV....YVSPDLR.KEFLDRRDEVVDIVVSQRD...P.G..MP.P...TCP.EA..CPFYSTCNG-r..........................
D3RZS6_FERPA/1-310                  ..................................................myyldvi------EV..KRL.tRDLLPRVRENQIDERLRGWNWFESPVRPYSDeLLLPVWDVATSICPTKRDAWIRhK.ILKRSVP..TT.I.QQA....KGFIVHKIISSMFLKAKKLVYLG.Y.E.EL....RDE....L.....I........KS...A...E..ENLKmel......gemS------Knleirek...dveelkdFCMKIAKWQ..AT..RIE..SKVLEVK....AKYPFLNEE...SLVQLS......FP..I.A.TETVVD.GSLLGLSKYLRADAAWMLGG.......I.I.F..DVK.L......GR.....KED.....WHRLQVAGYALAFESVF.ERPVDIGCTVYV.sRA.GEGI...RVDRDFY....IVDDYLR.SSFLEKRDELQMTLLRDVE...P.D..VA.D...KCP.RY..CVFRSYC---lk.........................
D9PZC8_ACIS3/1-262                  ...................................................mlqllr--------..QEL..KYLHGL--QLSVPSELRGWAWDRPPVRPRYR.AGLGVAEVAYYSCCPREAL-EA.R.LRGPRQD..--.A.AML....LGAAVHELFRRVAYGLQGLVGRG.V.E.PW....EAA....R.....R........VM...E...S..RAYA............EVASQLGLa...............gEAQRLRD--..LQ..GAL..AVMLAGD....ATLQRLLGG...SATGSW......AP..W.L.SEYVVD.GTPLGLARRLRVDA--LMSG.......A.V.V..EFK.V......GQ.....ARD.....WHAVQMAGYAMALESQL.EVPFDYGLLVSV..SL.SPP-...SLSVHGL....LLGEGPR.SRFLEARDSMAEE------...-.-..--.-...---.--..----------lassgv.....................
L0K8Q1_HALHC/1-305                  ...................................................myflts-----EER..QKL.vRGLLPKARQMEISDELRGWNWNQPPLEAMYE.EKLALYEIAGKYCPTGRDLYLR.K.VEGVKTE..WN.Q.AMI....QGKVLHDTLAELLVKAKKLMYCH.G.I.EG....QKI....I....iE........KL...Q...E..VSFV............ALEKWESKldqef......ylelkeKIKLMWQFE..YN..QLV..VRMQGLL....AKQPYIGVD...SLVNLT......IP..I.V.VEQKLD.GSFLGLSSYLSADAFNYCEP.......M.I.L..DLK.F......GK.....PKD.....FHKLTITGYALVMESIY.SYPVSVGCLVYP..EF.RGDR..iVVKKEFE....IIDDELR.QWFIEERDEKMRMVCEEID...P.E..VA.Q...NCY.QT..CPYYEQC---y..........................
A0A023X6Y1_9ACTN/1-284              ...................................................mfmpta----EEKK..RLL..RGTIPRARRLGVDDSLRGWMWSAPPLLSPYE.VPLGLAETANAYCPTARDVYAR.R.VLGASPE..PN.G.KMI....LGKDLHDTLGAWIVHAKKSLYTH.G.A.ND....LEA....A.....-........--...-...I..ESIR............TFPEPDLP.................EQKTLVLYE..AD..AVE..FRLREAV....SQFPRIRTD...ALVAHV......LP..V.T.LGQMLD.GAFLGLSRRLSTDLLNLGEP.......C.I.L..NII.F......GD.....EKR....pFHALTLAGYALVLEAVH.EFPVDVGVTVYV..DF.DGGR..pRIERDFT....VLGDEVR.MEFIEVRDEKQRMVADQSD...P.G..PC.E...GCE.AW..C---------s..........................
A2BKJ7_HYPBU/2-128                  ................................................vlprrvwdy--------..---..--IRSLGSEGPVYAEIRGWRFDY--VAPRYR.YRPSVSEVA-SYCPSHRDAYLQ.H.VRGLQPP..RS.L.RAQ....YGVLVHEFFLEPFRLVDRGADSL.E.A.LT....AG-....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------kyrlarrlgvradrflervyelgaila
Q9YCL7_AERPE/84-260                 ....................................................ahrvg--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................DAYRMFNYL..LR..RVR..ARGNEIRv.mnAVFEKAVEF...SAAARVd....gIP..V.A.VEPNVP.GGPVGLSDYVRPDLLVGIMPv.....dL.V.L..AGH.G......DR.....WVA.....RKELAIAGYALAVEAWT.GNPVDYGVVVGL..RV.NDGL...KIVWRLV....RVDDHLR.TRFLERRDAVARIIEYRSD...P.G..LP.E...ACP.PG..CVFREVCG--v..........................
A0A6N7IM04_9FIRM/1-309              ......................................................myf--FTDEEK..KNL.yRGLLPKAREMGVADELRGWNWPFPPLAPIYD.VLLAIYEVAGAYCPTGRDLYLR.R.VKGIKTR..PN.L.AMQ....KGTVLHGALAHLIVAAKRIIYEE.G.V.AN....YQK....I.....V........AR...L...-..NELP............LYPPECWPgeadpgedpenyarllrNVKVLTDFE..KS..RLI..ARIQEIL....VKQPYIGED...SLVSLA......IP..V.V.VEQKLD.GSFLGLSPNLSTDAVTYPEP.......V.I.V..DLK.F......GR.....PQP.....FHRLNTTGYALVMESLY.EFPVNLGCLVYA..EF.KDDR..lLVRKDLH....IISDELR.QRFCEVRDEKARLVAEEID...P.G..VP.E...NCP.AS..CPYFPFCR--...........................
E1QU80_VULDI/3-265                  ...........................................lprwvwdyikvtme--------..---..---------GGSYAEIRGWFRDA--VAPRHV.VRPTVSEVS-SPCPTKRDAYLR.R.VAGVTME..DS.E.SLR....LGRMVHEVFLTPFKESIPF----.S.Q.LD....NRF....E.....S........II...N...-..----............--------.................----EYGDL..GN..KYR..AQLYEVY....TK-AVATSL...NAREEG......IP..I.S.VEPAIP.GAPIGLSDIVKPDILVGFIPv.....eL.V.T..SSQpT......EE.....LTS.....RKDIAVTAYALAIEAWI.GHPVDIGVVLHI..SI.NGKP...RLTWRVV....KIDDTLR.RAFLDMRDNVARIIEHGDD...P.G..PA.S...SCP.RT..CPFYGVCHG-...........................
A0A4Y7RV06_9FIRM/1-306              .................................................myfltdee------RK..QLL..KNLLPRSRQMETAEELRGWNWHQPPLAPVYD.IKLALYEVANSYCNTGRDLYLR.R.VDRIKAK..PN.L.AMI....RGKIFHEILVRVLVRAKRLIYEK.G.V.GN....FQE....I.....I........KK...L...N..TPLDlsfl...seyqsRLQ----Edefv.........elqrKSAIIAAFE..NA..RVS..ARIQEIL....IKQPYIAED...SLAALA......IP..V.V.VEQKLD.GTFLGLSANLSADAFTFSEP.......M.V.L..DLK.F......GE.....PKK.....FHRLTTTGYALVMEAIH.EFPVNLGCLVYA..EF.KGDR..lVVKKDIH....IIDDELR.QWFIEERDNKMRMIYEEID...P.G..YG.-...ECR.DH..CPYILQCR--g..........................
A0A4R8HFU4_9FIRM/1-305              .......................................................my--FLTEEE..RQLlvRGLLPKSRRIGITDELRGWNWNQPPLEPMYD.HRLALYEIAGKYCLTGRDLYLR.K.IVGVKSK..WN.Q.AML....QGSILHDTLAELLVTAKRLIYSY.G.V.NK....QSL...iI.....E........EL...Q...K..PNFKhldkk.kgildeEFYSELRD.................KVGVIWQFE..YN..RLI..FRMQELL....AKQPYIGVD...SLANLT......IP..V.V.VEQKLD.GSFLGLSSHLSADAFNFCEP.......M.I.L..DLK.F......GK.....PRD.....FHKLTITGYAMVMESIY.SFPVSVGCLVYP..EF.KNGR..lLIKKEFC....IIDEELR.QWFIEERDEKMRIVSEEID...P.G..VA.N...KCY.QS..CPYFEECH--...........................
W7KGY0_9CREN/1-268                  .........................................................-------M..RQL..RRLHSYRASDPIDEDLRGWNYHSPPIKPRAY.LSLSVADVAYRYCDSKRDVYLR.K.VLKMKGE..QT.P.SLT....LGQQVHELIALISRDVTRLLAQG.L.P.AY....EVL....E.....V........IN...K...-..KRYN............TAFNPFLE.................KFKKAFAFY..--..---..-------....----LLSDA...SDSSGF......IP..L.I.SEFRVD.GTPLGLSPRLSADA-ISQLS.......M.V.V..EVK.V......AN.....YQD.....FHKLALAGYALALESAF.ELPVDFGALIYV.nGI.NEKY..pEIRTEAH....YLSTDLR.KEFIDARDEVIDMLLEEKD...P.G..LA.S...NCQ.SS..CPFYSYCR--r..........................
A0A2R4ZSS2_9CREN/7-298              .........................................................MLTRLEII..RGL..KKLHTIRARDPVPEELRGWSHNTPPVKPRAY.LGLGVGEIAYRYCETKRDLYLR.R.VLGIKGD..SGkA.PLV....NGAAIHKIFSEASRGVRKLALLG.K.PgPE....IYE....E.....L........SK...E...A..PRIAs..........tTCPEDLRI.................TCEKIYRYL..AL..MWS..AEIAKAR....IA--YGSQD...AAGL--......IP..W.I.TELRVD.GTLVGLSDRLSVDA-IAEAS.......I.V.I..EIK.T......GQ.....KKN.....FHKLALAGYALALESSL.ETPIDYGVLIYI.nPV.GEEP...EITLEPH....YISPDTR.KEFIDARDEAIDMILSSKD...P.G..IA.R...NCP.ET..CPFLEICG--vr.........................
A0A0M2U345_9FIRM/1-306              ................................................myfltdeek-------K..QLL..RGYLPKSRELGVNEELRGWNWHRPPLSPIYD.LKLALYEVANSYCPSNRDLYLR.R.VDGLKPA..PN.V.AMI....RGKAFHETLVQVLVRAKRTIYEK.G.V.TN....YQD....I.....I........RA...L...S..EPFQpdlr...pyrnqL-----TKsdfe.........dlqkKAITIAAFE..SS..RII..ARIQEIL....VKQPYIGED...SLVSLA......IP..V.V.AEQKLD.GSFLGLSANLSADAFTFSEP.......M.I.L..DLK.F......GE.....PKK.....FHRLTTTGYALVMEAVY.EFPVNLGCIVYA..DF.KDDR..lLIKKDIH....IIDDELR.QWFIEERDEKMRMVYEEID...P.S..LA.E...KCY.DT..CPCYSACHG-...........................
A0A348B575_9CREN/1-300              .........................................................MFFTPEDV..ALY.aKRVRQT--PRQVGEEMRGWRWPEPPLLPPSG.RTLPVSDASGALCQTGRYVYLS.Y.VKWVKAP..TS.P.EAA....RGSLIHEAYAESVETVRKLIYSG.E.V.VD....GNA....L.....R........SA...M...L..DEYY............EAERRLSEyssv........qdfhnVVKAIWDRA..TS..VFG..ASLDRAR....ER-ARGRRE...TLAAAT......IP..F.L.VEFPID.GSLVGLSPNSRVDALIPNVP.......L.V.V..EMK.T......GA.....RRR.....AHERALAGYALAYESQY.EVPVDFGLLCYV..RV.EDKV...SDRCELL....KIGEALR.TEFLEERDRRLQVLEDGVD...P.G..LP.K...FCD.RE..CPFLSHCGG-kv.........................
A0A4R2RGP8_9FIRM/1-312              ..................................................myfwtse-----EQK..RLL..RYFLPRARREGVAEELRGWNWNQPPLSPIYE.CSLAVYEVANGYCDSARDLYWR.R.VERVKAA..PN.K.AMV....QGRLFHALVAGMMVETKRRIYKY.GvD.AY....PEI....L.....R........EI...N...E..LGLN............ELLDEKTKqagktlde.etraqvldKMKLLLAFE..RG..RIV..ARMQEVL....VKQPYIGVD...SLAALT......VP..V.V.VEHKLD.GSFLGLSAHLSTDAYQMGES.......M.I.V..DLK.F......GE.....PRP.....FHRLATTGYALAMEAMY.EFPVNVGCVVYV..SF.AGDR..vRVQRDIH....LINDELR.QWFIEARDTKARLVAEELD...P.G..MA.K...ECQ.KD..CPYAGRCKG-g..........................
A0A2U9IJ08_9CREN/1-284              .........................................................MLTRLDMI..RGL..KSLHEIRATDPVQEELRGWYYYSPPVKPRAY.LSLSISDVAYAYCPTKRDVYLR.K.VTGSKGN..YE.KpQII....NGTAIHKVFYKASKDVWSIISLG.K.D.PI....ESF....N.....S........LA...P...-..--EL............ECPQNLQN.................YCIKLYKYL..TM..LWL..SEVAKAR....SS---YGGE...SIGL--......VP..W.L.SEVRVD.GSMLGLSNRLSIDA--IADF.......S.I.I..EIK.T......GK.....QED.....FHKLGVVGYALAIESSM.EIPIDYGFLIYV.nGF.NRDS..iEISTNAI....YISSDLR.KEFLDRRDDVIDMILSEKD...P.G..MP.A...SCP.DS..CPFIEVCR--k..........................
A0A0U2U6Q3_9CREN/4-108              .........................................rsvwdelrasageamv--------..---..--------------TVRGWDWSL--LQNRAP.VKPTVSEVT-SPCPTKRDSYLR.R.VLGARPS..-S.P.LLE....KGKMVHEAFMSPFRGEEREFKEE.L.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------lkkvheeaklrkaiad...........
O28400_ARCFU/1-281                  .........................................................MVYFLNELehKFL.tLELRPRIRQNPVPEELRGWNWHSPPLKPYYN.VKLPMYLICSRYCPTSRDVYLT.M.VEKVRGE..ES.F.PVS....LGKAIHEAVAKAIREAKSKNFSA.E.P.PN....YDN....E.....M........IN...V...-..----............--------.................AVKAVWEYT..MS..LCQ..SSYLKVR....SEQPYATEE...GVLLTS......MP..F.L.VEHRMD.GSLLGCSGLISVDCYDYLRN.......V.V.F..DLK.V......GE.....FNE.....EMRLYTTGYALVLESIH.EIPVDVGCIISI..TF.NGER..mRVSKDLH....YIDANLR.SWWIEERDRKAEIVFNEAD...P.G..VA.K...SCS.SN..CLFNAFC---l..........................
A0A2H5UZ86_9ARCH/2-70               ......................................................myy--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...----HS......FP..F.V.VNYLVN.GRVVGLSERNQADE-LGAVS.......L.V.L..IFK.R......GP.....PMD.....FYKLATTGYALALESSL.FQPV--------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------lg.........................
A8ABK7_IGNH4/16-105                 .......................................lprwvwdelratagetvv--------..---..--------------HTRGWDWQL--LQPRYK.ARPSVSDLT-SPCPTKRDVYLR.K.VLGVRLE..-S.E.AMS....KGRAVHEAFMAPFKGV-------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------eletedp....................
A3DLB8_STAMF/1-310                  .................................................myyldeie-------Y..KLL.iHDLLPRTRENPIDDRLRGWNWHQPPVRPYSFeLQLPIWEIAGSICPTYRDVWIR.RkVLRKKLF..TT.S.KQA....EGVIIHKIVSHVFKEAKKLIYSG.D.Y.SD....LKN....AllpgvK........EL...V...D..NEVKy.........isE----LVEnida........nkikeFALQVADWE..ML..RIE..GRINTVK....AKYPYIDEE...GLVSLA......VP..V.S.LEMPVD.GRLLGLSSMLRVDASWLPGG.......L.I.Y..EIK.T......GY.....REK.....WHKLQVAGYALALESIY.ERPVDIGVVVYV.nRA.VEGI...RVNRDIF....VVSDDLR.SRFLEKRDEIQMLLLKGEE...P.R..IP.D...KCP.RK..CLFRNICL--ge.........................
Q96X76_SULTO/1-279                  .....................................................miwr--------..QQL..KRLHRIREMDPVPDELRGWHYYSPPVKPKAY.LGLTMGEIAYDYCPTKRDVYVR.R.VLNQKGS..ER.A.QLV....FGQAIHKVFSKALNDVRISYVLG.K.D.PY....QIV....K.....E........SY...L...E..SE--............FCPQEISE.................YCRKVYGNL..IL..FWS..SWLAEAK....---AFYGGD...SVGF--......LP..W.A.TEVRVD.GSAIGLSDRLTVDA--LGEF.......T.V.V..EVK.S......GK.....REE.....FHKLALAGYALAIESVL.ELPVDYGLLVYI.nGF.PNDV...EIKFESY....YISPDMR.REILDKRDEIIEMVLNGRD...P.G..KP.V...KCP.ET..CPFYEVC---wk.........................
I3TFC8_THEC1/4-283                  ...................................................lfarrl------VL..RSV..RRLYAWSRADPVEEELRGWSWDRPPVKPRAY.LGLGVSEVAGKYCPTRRDVWLR.R.KMGLAPE..TT.E.PLA....KGRLVHEAVTAAVRCASRGLSRG.W.E.TW....DIL....T.....-........-Y...C...L..GRFR............PQGNGDTA.................TALKAYKST..LV..TLL..GEVEYE-....----RLVSG...G---SG......LP..V.V.SEMKVD.GTPLGLSPQLSIDV--YAEN.......I.V.V..DFK.T......GA.....PRD.....FHKLSIAGYALALEAEY.EVPVDYGILVYV.nPS.DSGL...RVLYRPV....YVSNELR.RWFLEERDEIVDMLVSNRE...P.P..KD.K...NCP.QT..CPFYRVCH--q..........................
CSA1_THETK/1-278                    .........................................................MLTLLEIA..RLL..RRAKVTQGPAEVSPELRGWAYDRQPVKPPAY.LGLALSDFAYGYCPTGRSLYLK.Y.VLGERPQ..PT.K.PLA....EGQALHAVLFKALEDFRRYVYSG.A.P.MS....PPG....E.....-........--...-...-..----............GMPEDLRA.................KAEALYRYI..AV..RLT..GEYQYVL....ASRLARSRD...AAAFYA......AP..I.A.AQIAVD.GAPLGLS-YVVADG--VALG.......A.V.V..EFK.F......GP.....SQN.....V-DVALAGYAMAIEAEY.GVPIDYGIHVQI..AV.DGQV...EYRASAY....VLGDAPR.AKFLEARDEAIDVVASARD...P.G..PA.P...QCP.KT..CPYYSVCR--s..........................
H9ZZA3_FERFK/2-297                  ........................................................m-QMLFSLV..KDV.pKRLYWLRSNDPVPEDLRGWSYHTYPVRPRAY.FGLGVSEVAYKYCETFRDLWMR.R.KEYVRGEvlES.S.PLY....MGKLIHSLMNYAFRDASEIVSRN.L.G.P-....--L....E.....S........IR...R...A..QELS...........rKRASELTK................sYYRKAMEFY..MT..MVL..SAISTLW....IQ-QSLTND...PLSY--......IS..I.K.TEFVID.GTPVGLSNTLRVDA-YHEGG.......V.I.I..EYK.L......GNpd.plLTE.....RHSVGLAGYALAIESSL.DIPIDYGAIVYI.sEL.SRRP...SIKVFPV....YISSLYR.KKFLENRDEAIEVLMRATP...P.P..RS.G...NCY.QY..CPFFKACNG-ge.........................
E0SSI5_IGNAA/1-240                  ........................................................m--------..---..-----YRASDPVDEGLRGWHWYEKPLRPRAF.LELSMADAVYRFCPSRRDLWLR.R.RIGVEGE..AS.D.GMR....KGFAIHSIFHISSGVVAKAIFSG.Y.S.PW....DAY....E.....Y........GY...R...-..----............----QCIK.................SAK-VYNNI..INveKLC..KEFSFIW....SS-------...MAMELG......SP..IaI.TEFTVD.GSLIGLSRNLRVDA-LFEGS.......V.I.I..ELK.Y......GS.....FRR.....DYIDVLAGYAIAMESFI.EMPIDFGILMLV..NS.DG-T...AIKIEPV....YIGNDVR.KEFIELRDEAIDILLS---...-.-..--.-...---.--..----------dv.........................
S5ZDL3_9CREN/1-117                  ........................................................m--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....---------...------......--..-.-.------.---LGLSRNLRVDA-LVETG.......V.V.I..EVK.L......GK.....PHE.....NYKRALAGYALALEANY.EVPVDYGILLYV.sIA.NGGK..vGFSWEPV....YISTSLR.SEFIDARDEVIDMLVSGKE...P.P..RA.E...VCP.ES..CPFRGVC---g..........................
A4YFV5_METS5/1-272                  ......................................................mrs-----QIT..RQL..RLLHSYRASDPIEEELRGWSYHHPPIKPRRY.LSLSMGDVAYRYCETKRDVYLR.-.RNGVQGE..AN.Q.ALN....HGLSVHRIFSTISREVSRLTLSG.L.P.PW....DVV....S.....-........IL...M...-..SRCSk..........lSRECQDRS.................GCEQACKSF..SL..DLI..SDYFD--....---------...STSF--......IP..T.I.SEFRVD.GTPLGLSPRLSVDA-ITQFS.......M.V.V..EIK.T......GT.....PQD.....FHKLALAGYALALESSL.ELPLDFGTLIYV..R-.--GG...ELRYESH....YVSPDLR.KEFLDSRDEVISMLSEDRD...P.G..LP.T...VCY.PS..CPFLSHCRG-g..........................
A0A0U2U6Q3_9CREN/90-237             .............................................eellkkvheeak--------..---..-------------------------------.----------------------.-.-------..--.-.---....-----------------------.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------....-----LRKA...IADEEG......IP..Y.K.VESKLP.GSVIGLSTIVKPDFLVGFMP.......V.E.L..VYG.W......NG.....NVE.....RKKLALAAYALVIEAWT.GLPIDAGVVINV..N-.-D-Q...GIKYVLV....RIGDYYR.RKFLEERDYLASILSRKED...P.G..RA.E...SCP.NY..CPFAEVCK--q..........................
#=GC seq_cons                       ...................................................................p.L..+thh.h.tttsls-ELRGWsappsPltPhh..htLul.-lu.taCsTtRDlYLR.+.Vhthpsp...s.t.thh....tGphlHchhspshtps++hlhpt.h..........th................................th.............th.....t.................hsphlhph...h...th...uchtphh.....p..hhst-...uhsths......lP..h.h.sE.tlD.GohlGLSttLpsDA.hh..s.......h.l.l..-hK.h......Gp......pc.....hHcLslsGYALAhEu.h.EhPl-hGhllYl..ph.ptph...tlphchh....hIs-pLR.ptFlEtRDchhchl.pthD...P.G..hs.t...pC..tt..CPahphC...h..........................
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