GenomeNet

Database: Pfam
Entry: Csm1_N
LinkDB: Csm1_N
Original site: Csm1_N 
#=GF ID   Csm1_N
#=GF AC   PF18504.3
#=GF DE   Csm1 N-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF05456
#=GF GA   26.30 26.30;
#=GF TC   26.30 26.50;
#=GF NC   26.20 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF RN   [1]
#=GF RM   20723757
#=GF RT   The monopolin complex crosslinks kinetochore components to
#=GF RT   regulate chromosome-microtubule attachments.
#=GF RA   Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC;
#=GF RL   Cell. 2010;142:556-567.
#=GF DR   INTERPRO; IPR041671;
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   In the budding yeast Saccharomyces cerevisiae, sister chromatid
#=GF CC   co-orientation in meiosis I depends on the four-protein
#=GF CC   monopolin complex (Mam1, Csm1, Lrs4, and Hrr25/casein kinase 1),
#=GF CC   which localizes to centromeres from meiotic prophase through
#=GF CC   metaphase I. Csm1 and Lrs4, form a complex that resides in the
#=GF CC   nucleolus during interphase and relocalizes to centromeres
#=GF CC   during meiotic prophase, accompanied by phosphorylation of Lrs4.
#=GF CC   This is the N-terminal domain of Csm1 which forms a coiled-coil
#=GF CC   [1].
#=GF SQ   28
#=GS H2B131_KAZAF/1-70         AC H2B131.1
#=GS M1VGV8_CYAM1/345-410      AC M1VGV8.1
#=GS C5DC27_LACTC/1-70         AC C5DC27.1
#=GS J7S2J4_KAZNA/1-70         AC J7S2J4.1
#=GS I2H5E5_TETBL/2-71         AC I2H5E5.1
#=GS G0WFM8_NAUDC/4-73         AC G0WFM8.1
#=GS J8LQT7_SACAR/1-70         AC J8LQT7.1
#=GS Q6FVN3_CANGA/1-70         AC Q6FVN3.1
#=GS Q6FVN3_CANGA/1-70         DR PDB; 6MJE A; 69-70;
#=GS Q6FVN3_CANGA/1-70         DR PDB; 6MJE C; 69-70;
#=GS Q6FVN3_CANGA/1-70         DR PDB; 6MJB B; 69-70;
#=GS Q6FVN3_CANGA/1-70         DR PDB; 6MJC A; 69-70;
#=GS Q6FVN3_CANGA/1-70         DR PDB; 6MJE G; 69-70;
#=GS Q6FVN3_CANGA/1-70         DR PDB; 6MJE E; 69-70;
#=GS A0A1G4ILN9_9SACH/1-70     AC A0A1G4ILN9.1
#=GS Q751E1_ASHGO/1-70         AC Q751E1.1
#=GS G8JQ87_ERECY/24-93        AC G8JQ87.1
#=GS G8C0R1_TETPH/2-71         AC G8C0R1.1
#=GS CSM1_YEAST/1-70           AC P25651.1
#=GS CSM1_YEAST/1-70           DR PDB; 5KTB A; 20-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N7N A; 3-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N4X B; 3-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N4X D; 3-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N4X C; 16-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N4R C; 69-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N4X A; 17-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N7N D; 3-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N4R D; 69-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N7N C; 8-70;
#=GS CSM1_YEAST/1-70           DR PDB; 3N7N B; 4-70;
#=GS CSM1_YEAST/1-70           DR PDB; 5KTB B; 13-70;
#=GS C5DWT0_ZYGRC/1-69         AC C5DWT0.1
#=GS Q6CKJ3_KLULA/1-70         AC Q6CKJ3.1
#=GS G8ZNB7_TORDC/1-70         AC G8ZNB7.1
#=GS A0A1X7R5E9_9SACH/1-71     AC A0A1X7R5E9.1
#=GS A7TFZ2_VANPO/2-71         AC A7TFZ2.1
#=GS A0A1E5R1G5_9ASCO/16-85    AC A0A1E5R1G5.1
#=GS A0A1S7HNY6_9SACH/1-69     AC A0A1S7HNY6.1
#=GS J5PIX1_SACK1/1-70         AC J5PIX1.1
#=GS G0VER7_NAUCC/1-70         AC G0VER7.1
#=GS A0A0C7N3D1_9SACH/1-70     AC A0A0C7N3D1.1
#=GS A0A1G4M994_LACFM/1-70     AC A0A1G4M994.1
#=GS A0A1G4JNI1_9SACH/1-70     AC A0A1G4JNI1.1
#=GS A0A1S7HKA6_9SACH/1-69     AC A0A1S7HKA6.1
#=GS A0A4Y8IHN3_9BACI/106-171  AC A0A4Y8IHN3.1
#=GS A0A376BAC8_9ASCO/25-94    AC A0A376BAC8.1
H2B131_KAZAF/1-70                    ......MEALIEYKESVKEQLENADLLITKLVNENSTLNEKLRVKDDRISNLENEIANLKQQVVKTQQQLKDKAEN......
M1VGV8_CYAM1/345-410                 ....ra---FEEYRASVAVQLDAAERLVERYKSENEQLRQQLDH--AEVAKLRQRVDDLERTRTDQQLR-------ylelqk
C5DC27_LACTC/1-70                    ......MDPISQYKAAVQSRLDNADILVSKLVHENRMLAQDVENKDQEIESLKRQLAAAEARSKECEERTGAAEEE......
J7S2J4_KAZNA/1-70                    ......MNALQEYKDSVQERLNSADLLVSKAVHENSILTERLETQERELEALRKRVAELEVDCQGAKDDRNSSVED......
I2H5E5_TETBL/2-71                    ......VDPLVEYKNSVEKRLNDAELLINRLIHENSVKDQLLEQRDEEISQLKATIEKLDEKSSSQLKKYDLSLEN......
G0WFM8_NAUDC/4-73                    ......MDPLTTYKRSIQERLDAADVLVSKLTLENSLLNTAVDTHKQEVQSLKKQVKTLNEQLDGSKTSNEKQKET......
J8LQT7_SACAR/1-70                    ......MDPLTVYKNSVKQQIDSADLLVANLVNENFILSEKMNTKSTEIEQLQKQIDSLNTEVKDLKTQVSQQTEN......
Q6FVN3_CANGA/1-70                    ......MDPLSEYKKSVQKRLDAADLLVERVVQENTLLRQKLDSRDVELESVKEQLAVLRSKRDELDERSQKDKET......
#=GR Q6FVN3_CANGA/1-70         SS    ......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHH......
A0A1G4ILN9_9SACH/1-70                ......MEPLVEYRKAVQERLNNADVLVAKLVHENGLAAQELENKQQELELLRSRLDERDDRLRQADKARAAAVEE......
Q751E1_ASHGO/1-70                    ......MDPLSRYKQAVQQRLDSAERAVSKVVHENTVLAQQLATREKEVAALQAQVAEAEEARARAQTRQATLEEE......
G8JQ87_ERECY/24-93                   ......MDPLSRYKHAVQQRLDNAELAVSKVVYENTLLSQQLSTKDQEIKRLREQVLELEEDGRQIDEKRRQLQEE......
G8C0R1_TETPH/2-71                    .....a-NTLEQYKKLIGERLDNADLLVSKLVLENSLLKQQLESKDEQLKLLNGRLEHLAAQEQRHASALQDANE-a.....
CSM1_YEAST/1-70                      ......MDPLTVYKNSVKQQIDSADLLVANLVNENFVLSEKLDTKATEIKQLQKQIDSLNAQVKELKTQTSQQAEN......
#=GR CSM1_YEAST/1-70           SS    ......XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH......
C5DWT0_ZYGRC/1-69                    ......MDALSQYRDSVKERLENADLLVSKLVHENTILEQSLEIRNQELESNRRRIRELEEQSKQSDESM------elvkd.
Q6CKJ3_KLULA/1-70                    ......MDPLAEYKESVQDRLEKADLAVQGVLNENVKLMRQLELKQQEIESLKEQLQSDKTKISQLEDSKADAEEQ......
G8ZNB7_TORDC/1-70                    ......MDALTQYKRALQEQLESADLLIAKLVHENTVLSQTVETRTKKNQGLQERLQSVEERVKDLESRETKQEES......
A0A1X7R5E9_9SACH/1-71                ......MDTLVEYKKSVQKQLESNELLVAKLVHENTLLTQQLEGKTQQLELLQDELKKLKETRVSLQKELDTHQ--dev...
A7TFZ2_VANPO/2-71                    .....s-DSFIQYKKSIKERLDNADLLVSKVIHENTLLSQQLDSRNEEISYMKEKLDKHKTKVDSLNDKITKQNEN......
A0A1E5R1G5_9ASCO/16-85               .....n-DEIVQYKKLLNKRLEKSDLLINQLLLENEMLQKKLDTLSIQHAGLQQEYKQTCDKLVLIDEKLNEQED-n.....
A0A1S7HNY6_9SACH/1-69                ......MDALTQYKNSVQQRLDNADLLVAKLVHENTILGQTIELRNQALEASESQIKELKDRIKDLEESM------elvkd.
J5PIX1_SACK1/1-70                    ......MDPLTVYKNSLKQQIDSADLLVANLVNENFMLSEKLDAKSSEIKQLQKQIDSLNGQMTDLKTQVSHQTEN......
G0VER7_NAUCC/1-70                    ......MDPLTQYKESVKEQSENAELLIAKLIHENSVLTTKNDTYSQEVETLRLQMAKLQEQLKVSEELRKKQAEN......
A0A0C7N3D1_9SACH/1-70                ......MDPLVQYKASIQNRLDSADVLVSKLVHENRMLAQETENKDEEIKALKQQLESIKKRNEEDEKRANVAEEE......
A0A1G4M994_LACFM/1-70                ......MDPLVEYKNSVQNRLDNADILVSRLVHENSLLSQEVENRDQEIETLKRQLETHKREEEERQHRMTSLEEE......
A0A1G4JNI1_9SACH/1-70                ......MDALTQYKTSIQSRLDSADILVSKLIHENRMLSQELENKDEEMDSLKRQLELARKRNEEFDKKCSTAEEE......
A0A1S7HKA6_9SACH/1-69                ......MDALTQYKNSIQQRLDNADLLVAKLVHENTILGQTIELRNQALEASESQIKELKDRIKDLEESM------elvkd.
A0A4Y8IHN3_9BACI/106-171             kqnldd----------VRDRLKHSDDYVNKLTQEKAQLEQTVSDKDTEIGRLEDQIANRNMKYDQLMEDYQD----mqmr..
A0A376BAC8_9ASCO/25-94               .....n-DILYKYKQSVQKRLDSGDLLISKLIHENTLLKQQLDNKQQEIDILQDKIVKLDEICQNLNRGNLKCKE-d.....
#=GC SS_cons                         ......XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH......
#=GC seq_cons                        ......MDsLspYKpSVppRLDsADLLVuKLVaENolLsQpL-s+spElctLccplcpLccchcphccphpptpEp......
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