GenomeNet

Database: Pfam
Entry: DDHD
LinkDB: DDHD
Original site: DDHD 
#=GF ID   DDHD
#=GF AC   PF02862.19
#=GF DE   DDHD domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   28.30 28.30;
#=GF TC   28.40 28.30;
#=GF NC   28.20 28.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10022914
#=GF RT   Identification of a novel family of targets of PYK2 related to
#=GF RT   Drosophila retinal degeneration B (rdgB) protein. 
#=GF RA   Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger
#=GF RA   J; 
#=GF RL   Mol Cell Biol 1999;19:2278-2288.
#=GF DR   INTERPRO; IPR004177;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The DDHD domain is 180 residues long and contains four conserved
#=GF CC   residues that may form a metal binding site. The domain is named
#=GF CC   after these four residues.  This pattern of conservation of
#=GF CC   metal binding residues is often seen in phosphoesterase domains.
#=GF CC   This domain is found in retinal degeneration B proteins, as well
#=GF CC   as a family of probable phospholipases. It has been shown that
#=GF CC   this domain is found in a longer C terminal region that binds to
#=GF CC   PYK2 tyrosine kinase. These proteins have been called N-terminal
#=GF CC   domain-interacting receptor (Nir1, Nir2 and Nir3) [1]. This
#=GF CC   suggests that this region is involved in functionally important
#=GF CC   interactions in other members of this family.
#=GF SQ   6005
#=GS A0A5J4ND03_9TREM/397-697    AC A0A5J4ND03.1
#=GS F7AL38_CIOIN/403-625        AC F7AL38.2
#=GS I3K7P6_ORENI/555-758        AC I3K7P6.2
#=GS A0A1V6Z4G4_PENNA/852-944    AC A0A1V6Z4G4.1
#=GS A0A4W2EFI4_BOBOX/655-901    AC A0A4W2EFI4.1
#=GS A0A674A8V6_SALTR/685-928    AC A0A674A8V6.1
#=GS B4G8N1_DROPE/1603-1830      AC B4G8N1.1
#=GS A0A484AYB9_DRONA/742-874    AC A0A484AYB9.1
#=GS A0A2I3N843_PAPAN/789-874    AC A0A2I3N843.1
#=GS Q6ZC54_ORYSJ/821-874        AC Q6ZC54.1
#=GS G0N5S1_CAEBE/568-660        AC G0N5S1.1
#=GS A0A078GR81_BRANA/662-813    AC A0A078GR81.1
#=GS A0A068RMG9_9FUNG/530-800    AC A0A068RMG9.1
#=GS A0A5B6WTL2_9ROSI/291-454    AC A0A5B6WTL2.1
#=GS A0A1A6GC50_NEOLE/702-864    AC A0A1A6GC50.1
#=GS A0A0V0YEZ9_TRIPS/323-445    AC A0A0V0YEZ9.1
#=GS A0A0A2VPL3_BEABA/383-498    AC A0A0A2VPL3.1
#=GS A0A5N3X0V7_MUNRE/339-541    AC A0A5N3X0V7.1
#=GS A0A674EQT2_SALTR/394-603    AC A0A674EQT2.1
#=GS A0A401L802_ASPAW/1323-1414  AC A0A401L802.1
#=GS A0A2T3B5W2_AMORE/1031-1107  AC A0A2T3B5W2.1
#=GS A0A2D3UYL3_9PEZI/661-997    AC A0A2D3UYL3.1
#=GS A0A2G4SMH9_RHIZD/190-447    AC A0A2G4SMH9.1
#=GS A0A2I3S0N2_PANTR/390-593    AC A0A2I3S0N2.1
#=GS A0A1M8A9X8_MALS4/561-688    AC A0A1M8A9X8.1
#=GS B4M3R6_DROVI/845-908        AC B4M3R6.1
#=GS A0A5N6TWJ1_9EURO/753-860    AC A0A5N6TWJ1.1
#=GS A0A4S2LH59_OPIFE/631-911    AC A0A4S2LH59.1
#=GS A0A1Y1ZTE1_9PLEO/716-840    AC A0A1Y1ZTE1.1
#=GS A0A1V2L9H6_CYBFA/437-634    AC A0A1V2L9H6.1
#=GS A0A090LLV8_STRRB/420-665    AC A0A090LLV8.1
#=GS A0A384BR85_URSMA/819-1028   AC A0A384BR85.1
#=GS A0A175VW59_9PEZI/651-982    AC A0A175VW59.1
#=GS A0A094HN33_9PEZI/691-818    AC A0A094HN33.1
#=GS A0A4W5NFP0_9TELE/623-869    AC A0A4W5NFP0.1
#=GS A0A2K3QPI6_9HYPO/799-914    AC A0A2K3QPI6.1
#=GS A0A317WRM1_9EURO/851-943    AC A0A317WRM1.1
#=GS E9GU79_DAPPU/480-685        AC E9GU79.1
#=GS G1MXW3_MELGA/656-756        AC G1MXW3.1
#=GS I6NE41_ERECY/553-621        AC I6NE41.1
#=GS A0A2Y9DZM9_TRIMA/507-711    AC A0A2Y9DZM9.1
#=GS A0A6G0TD07_APHGL/812-873    AC A0A6G0TD07.1
#=GS A0A0E0I6H5_ORYNI/677-822    AC A0A0E0I6H5.1
#=GS G3RNP6_GORGO/376-579        AC G3RNP6.2
#=GS A0A1J7IKW3_9PEZI/882-973    AC A0A1J7IKW3.1
#=GS A0A1B8GN02_9PEZI/671-992    AC A0A1B8GN02.1
#=GS A0A485L665_9STRA/431-535    AC A0A485L665.1
#=GS A0A0D2TSB4_GOSRA/743-818    AC A0A0D2TSB4.1
#=GS H0UV64_CAVPO/699-942        AC H0UV64.2
#=GS A0A5N4C9X1_CAMDR/710-943    AC A0A5N4C9X1.1
#=GS A0A674F0T8_SALTR/607-871    AC A0A674F0T8.1
#=GS A0A669DMH0_ORENI/725-935    AC A0A669DMH0.1
#=GS A0A4X2K229_VOMUR/777-957    AC A0A4X2K229.1
#=GS A0A2S4KV25_9HYPO/899-996    AC A0A2S4KV25.1
#=GS U5H3T0_USTV1/483-723        AC U5H3T0.1
#=GS A0A074Y6J5_AURPU/641-932    AC A0A074Y6J5.1
#=GS A0A2R2MK27_LINUN/364-504    AC A0A2R2MK27.1
#=GS A0A1Y2C4W6_9FUNG/116-776    AC A0A1Y2C4W6.1
#=GS D6WG59_TRICA/679-812        AC D6WG59.2
#=GS A0A5E4FA25_PRUDU/675-828    AC A0A5E4FA25.1
#=GS A0A081CBT4_PSEA2/670-951    AC A0A081CBT4.1
#=GS A0A093ZQP8_9PEZI/1527-1645  AC A0A093ZQP8.1
#=GS A0A4Z1JEM9_9HELO/737-1055   AC A0A4Z1JEM9.1
#=GS A0A6G0IL58_LARCR/542-780    AC A0A6G0IL58.1
#=GS H0XEC8_OTOGA/701-948        AC H0XEC8.1
#=GS A0A5A9PET1_9TELE/545-604    AC A0A5A9PET1.1
#=GS B2WN57_PYRTR/600-914        AC B2WN57.1
#=GS A7S326_NEMVE/830-898        AC A7S326.1
#=GS A0A383Z7E1_BALAS/686-824    AC A0A383Z7E1.1
#=GS A0A2H3IS02_9EURO/773-866    AC A0A2H3IS02.1
#=GS A0A421JAI8_9ASCO/517-738    AC A0A421JAI8.1
#=GS A0A674A9A8_SALTR/571-682    AC A0A674A9A8.1
#=GS A0A3Q1EX18_9TELE/560-763    AC A0A3Q1EX18.1
#=GS A0A0V0WCA9_9BILA/703-799    AC A0A0V0WCA9.1
#=GS A0A3Q0G7H6_ALLSI/701-964    AC A0A3Q0G7H6.1
#=GS A0A1A6GNY1_NEOLE/440-611    AC A0A1A6GNY1.1
#=GS A0A2U4AEL6_TURTR/657-748    AC A0A2U4AEL6.1
#=GS A0A151IQ16_9HYME/233-297    AC A0A151IQ16.1
#=GS A0A2Y9GNT1_NEOSC/686-823    AC A0A2Y9GNT1.1
#=GS A0A671FR74_RHIFE/390-593    AC A0A671FR74.1
#=GS A0A2U9AWJ1_SCOMX/694-886    AC A0A2U9AWJ1.1
#=GS PITM3_MOUSE/390-593         AC Q3UHE1.2
#=GS A0A3Q0G3R8_ALLSI/701-944    AC A0A3Q0G3R8.1
#=GS A0A2S6C292_9PEZI/643-981    AC A0A2S6C292.1
#=GS E3NCQ1_CAERE/529-641        AC E3NCQ1.1
#=GS A0A565AXG4_9BRAS/859-941    AC A0A565AXG4.1
#=GS A5DI15_PICGU/517-591        AC A5DI15.2
#=GS S2JGF3_MUCC1/105-394        AC S2JGF3.1
#=GS H2Q491_PANTR/686-824        AC H2Q491.2
#=GS A0A4U1FCC2_MONMO/298-501    AC A0A4U1FCC2.1
#=GS F1MD99_BOVIN/322-524        AC F1MD99.3
#=GS A0A1D6LDU7_MAIZE/503-657    AC A0A1D6LDU7.1
#=GS A0A1X7TAF1_AMPQE/308-505    AC A0A1X7TAF1.1
#=GS A0A178ZYJ0_9EURO/827-916    AC A0A178ZYJ0.1
#=GS A0A673A0F6_9TELE/691-920    AC A0A673A0F6.1
#=GS A0A015ICP3_RHIIW/496-724    AC A0A015ICP3.1
#=GS A0A1L9PHS8_ASPVE/605-888    AC A0A1L9PHS8.1
#=GS A0A161WGC4_9PEZI/917-998    AC A0A161WGC4.1
#=GS A0A395MM27_9HYPO/892-971    AC A0A395MM27.1
#=GS A0A0V1KWM9_9BILA/588-755    AC A0A0V1KWM9.1
#=GS A0A6H5KBT1_9PHAE/835-1169   AC A0A6H5KBT1.1
#=GS A0A5F8HCE2_MONDO/648-897    AC A0A5F8HCE2.1
#=GS A0A3P8U2A7_AMPPE/452-649    AC A0A3P8U2A7.1
#=GS A0A672GVN9_SALFA/564-805    AC A0A672GVN9.1
#=GS A0A287BH48_PIG/606-809      AC A0A287BH48.1
#=GS A0A6I8U3B1_AEDAE/849-910    AC A0A6I8U3B1.1
#=GS A0A643CK70_BALPH/743-803    AC A0A643CK70.1
#=GS A0A428P3X1_9HYPO/681-1002   AC A0A428P3X1.1
#=GS A0A1B8E2V3_9PEZI/690-806    AC A0A1B8E2V3.1
#=GS U3J2K4_ANAPP/797-861        AC U3J2K4.2
#=GS A0A670JR50_PODMU/417-619    AC A0A670JR50.1
#=GS A0A061D217_BABBI/203-472    AC A0A061D217.1
#=GS A0A103Y2G6_CYNCS/764-842    AC A0A103Y2G6.1
#=GS A0A671VNG8_SPAAU/705-944    AC A0A671VNG8.1
#=GS R7V5A8_CAPTE/574-783        AC R7V5A8.1
#=GS A0A0R3TK04_RODNA/571-725    AC A0A0R3TK04.2
#=GS A0A5F4DK70_CANLF/767-825    AC A0A5F4DK70.1
#=GS M4E339_BRARP/668-814        AC M4E339.1
#=GS A0A6Q2WY94_ESOLU/273-497    AC A0A6Q2WY94.1
#=GS W5LJZ4_ASTMX/728-790        AC W5LJZ4.2
#=GS A0A4Z2DVN2_SCHJA/676-904    AC A0A4Z2DVN2.1
#=GS A0A0L8GJU7_OCTBM/748-955    AC A0A0L8GJU7.1
#=GS A0A674F2J9_SALTR/772-819    AC A0A674F2J9.1
#=GS A0A4W4FC74_ELEEL/705-753    AC A0A4W4FC74.1
#=GS A0A1S3W601_ERIEU/857-922    AC A0A1S3W601.1
#=GS G3WL80_SARHA/582-843        AC G3WL80.1
#=GS A0A5A9PET1_9TELE/393-541    AC A0A5A9PET1.1
#=GS A0A3N7G8N7_POPTR/677-819    AC A0A3N7G8N7.1
#=GS A0A0Q9WW60_DROMO/741-875    AC A0A0Q9WW60.1
#=GS A0A091PWN2_HALAL/333-576    AC A0A091PWN2.1
#=GS A0A4S2KVE7_9HYME/898-959    AC A0A4S2KVE7.1
#=GS A0A0V1P8F5_9BILA/683-780    AC A0A0V1P8F5.1
#=GS A0A2I0RMY8_9PEZI/637-973    AC A0A2I0RMY8.1
#=GS A0A667YCA1_9TELE/742-952    AC A0A667YCA1.1
#=GS A0A4W2E8U6_BOBOX/614-814    AC A0A4W2E8U6.1
#=GS A0A4Z1KVR3_9HELO/1297-1394  AC A0A4Z1KVR3.1
#=GS L8IMY7_9CETA/496-700        AC L8IMY7.1
#=GS A0A1Y2LNS0_EPING/819-906    AC A0A1Y2LNS0.1
#=GS A0A0P8XL19_DROAN/853-916    AC A0A0P8XL19.1
#=GS A0A6P9E976_JUGRE/692-846    AC A0A6P9E976.1
#=GS A0A194Q4N2_PAPXU/2277-2461  AC A0A194Q4N2.1
#=GS A0A672U784_STRHB/700-932    AC A0A672U784.1
#=GS A0A3N7GBV0_POPTR/677-823    AC A0A3N7GBV0.1
#=GS A0A672H5A6_SALFA/332-422    AC A0A672H5A6.1
#=GS F2URE2_SALR5/560-790        AC F2URE2.1
#=GS A0A6I8SH97_XENTR/701-941    AC A0A6I8SH97.1
#=GS E2R183_CANLF/697-944        AC E2R183.3
#=GS A0A3Q3A387_KRYMA/747-953    AC A0A3Q3A387.1
#=GS A0A2Y9MV08_DELLE/616-890    AC A0A2Y9MV08.1
#=GS A0A4C2ABA0_EUMVA/274-401    AC A0A4C2ABA0.1
#=GS F1N662_BOVIN/693-886        AC F1N662.3
#=GS U3CSB1_CALJA/690-827        AC U3CSB1.1
#=GS G3J5U7_CORMM/642-923        AC G3J5U7.1
#=GS A0A0Q3PPT1_AMAAE/456-557    AC A0A0Q3PPT1.1
#=GS A0A2A2JBX5_9BILA/494-582    AC A0A2A2JBX5.1
#=GS A0A068RG62_9FUNG/430-634    AC A0A068RG62.1
#=GS T0Q7A3_SAPDV/341-466        AC T0Q7A3.1
#=GS A0A4V6RG73_9HYME/1220-1423  AC A0A4V6RG73.1
#=GS I3KDY9_ORENI/689-927        AC I3KDY9.2
#=GS V8NZB7_OPHHA/426-546        AC V8NZB7.1
#=GS A0A540L7W5_MALBA/632-783    AC A0A540L7W5.1
#=GS A0A672UY74_STRHB/368-571    AC A0A672UY74.1
#=GS A0A4W5PFW0_9TELE/613-866    AC A0A4W5PFW0.1
#=GS A0A453S1Z9_AEGTS/806-876    AC A0A453S1Z9.1
#=GS H2NSF7_PONAB/384-587        AC H2NSF7.1
#=GS A0A0D2SEU3_GOSRA/678-823    AC A0A0D2SEU3.1
#=GS A0A0K9PFC1_ZOSMR/114-191    AC A0A0K9PFC1.1
#=GS A0A4W2DZP6_BOBOX/322-524    AC A0A4W2DZP6.1
#=GS A0A162IEF0_9PEZI/1027-1120  AC A0A162IEF0.1
#=GS G1PGM3_MYOLU/413-594        AC G1PGM3.1
#=GS A0A1D6PX91_MAIZE/821-894    AC A0A1D6PX91.1
#=GS A0A368RH70_SETIT/665-815    AC A0A368RH70.1
#=GS A0A665WBU7_ECHNA/809-867    AC A0A665WBU7.1
#=GS A0A074Y613_AURSE/650-778    AC A0A074Y613.1
#=GS A0A2G2XSB9_CAPBA/854-1052   AC A0A2G2XSB9.1
#=GS A0A0V0SEX2_9BILA/628-761    AC A0A0V0SEX2.1
#=GS A0A1V9YQE6_9STRA/342-472    AC A0A1V9YQE6.1
#=GS A0A436ZZ59_9PEZI/693-809    AC A0A436ZZ59.1
#=GS A0A671UUN5_SPAAU/640-741    AC A0A671UUN5.1
#=GS A0A1S3P5G3_SALSA/626-688    AC A0A1S3P5G3.1
#=GS A0A4U0W0N6_9BASI/713-946    AC A0A4U0W0N6.1
#=GS A0A2P8Z3N2_BLAGE/505-744    AC A0A2P8Z3N2.1
#=GS I3MFG5_ICTTR/700-944        AC I3MFG5.2
#=GS A0A1V6P3G5_9EURO/747-865    AC A0A1V6P3G5.1
#=GS K9FY06_PEND2/854-947        AC K9FY06.1
#=GS A0A3L6PPJ7_PANMI/831-888    AC A0A3L6PPJ7.1
#=GS B7PL48_IXOSC/403-598        AC B7PL48.1
#=GS A0A1V4JPP7_PATFA/678-778    AC A0A1V4JPP7.1
#=GS L5KAN0_PTEAL/499-702        AC L5KAN0.1
#=GS A0A4W6GBE8_LATCA/703-947    AC A0A4W6GBE8.1
#=GS A0A1X7S3C3_ZYMTR/691-816    AC A0A1X7S3C3.1
#=GS A0A1X2G817_9FUNG/392-622    AC A0A1X2G817.1
#=GS D0MT42_PHYIT/882-1089       AC D0MT42.1
#=GS A0A1Z5TT13_HORWE/673-1022   AC A0A1Z5TT13.1
#=GS F9FA37_FUSOF/679-996        AC F9FA37.1
#=GS A0A075AGQ9_9TREM/51-267     AC A0A075AGQ9.1
#=GS A1C7P0_ASPCL/836-923        AC A1C7P0.1
#=GS A0A428PPF2_9HYPO/905-987    AC A0A428PPF2.1
#=GS A0A5E4F9K5_PRUDU/462-615    AC A0A5E4F9K5.1
#=GS A0A2K5LSF1_CERAT/779-988    AC A0A2K5LSF1.1
#=GS A0A195AW75_9HYME/829-898    AC A0A195AW75.1
#=GS F6SLJ1_ORNAN/497-703        AC F6SLJ1.3
#=GS A0A670HN88_PODMU/683-817    AC A0A670HN88.1
#=GS W3X8H6_PESFW/820-943        AC W3X8H6.1
#=GS A0A139WLJ0_TRICA/679-812    AC A0A139WLJ0.1
#=GS A0A2T3B5W2_AMORE/904-1025   AC A0A2T3B5W2.1
#=GS A0A4W4HBA4_ELEEL/745-822    AC A0A4W4HBA4.1
#=GS A0A2S4KV25_9HYPO/794-911    AC A0A2S4KV25.1
#=GS A0A553Q8S4_9TELE/612-851    AC A0A553Q8S4.1
#=GS A0A3B5PYS4_XIPMA/701-1036   AC A0A3B5PYS4.1
#=GS A0A287WYV9_HORVV/799-871    AC A0A287WYV9.1
#=GS A0A2J8MCW4_PANTR/715-962    AC A0A2J8MCW4.1
#=GS A0A024GFC0_9STRA/421-519    AC A0A024GFC0.1
#=GS A0A3Q3MKY6_9TELE/634-725    AC A0A3Q3MKY6.1
#=GS A0A3L8RTQ5_CHLGU/387-590    AC A0A3L8RTQ5.1
#=GS A0A0V0VFK0_9BILA/726-823    AC A0A0V0VFK0.1
#=GS A0A5N4CEY9_CAMDR/513-712    AC A0A5N4CEY9.1
#=GS A0A0F7TNS3_PENBI/874-956    AC A0A0F7TNS3.1
#=GS A0A182GJX9_AEDAL/657-861    AC A0A182GJX9.1
#=GS A0A5D2VVD2_GOSMU/678-829    AC A0A5D2VVD2.1
#=GS A0A091PJ44_LEPDC/181-374    AC A0A091PJ44.1
#=GS A0A167EVR3_9ASCO/591-844    AC A0A167EVR3.1
#=GS S3CAT4_OPHP1/742-1054       AC S3CAT4.1
#=GS W6MJY4_9ASCO/582-656        AC W6MJY4.1
#=GS L8I2I1_9CETA/697-931        AC L8I2I1.1
#=GS A0A395HAH3_9EURO/868-952    AC A0A395HAH3.1
#=GS A0A0N0NLL4_9EURO/690-808    AC A0A0N0NLL4.1
#=GS A0A267E1C7_9PLAT/603-826    AC A0A267E1C7.1
#=GS A0A267EDV4_9PLAT/217-581    AC A0A267EDV4.1
#=GS A0A2P4SPH3_BAMTH/644-707    AC A0A2P4SPH3.1
#=GS A0A094HN33_9PEZI/805-894    AC A0A094HN33.1
#=GS A0A0Q3UT70_AMAAE/546-613    AC A0A0Q3UT70.1
#=GS H0YF17_HUMAN/1-201          AC H0YF17.1
#=GS A0A0B7NPB7_9FUNG/173-655    AC A0A0B7NPB7.1
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