GenomeNet

Database: Pfam
Entry: DHHC
LinkDB: DHHC
Original site: DHHC 
#=GF ID   DHHC
#=GF AC   PF01529.22
#=GF DE   DHHC palmitoyltransferase
#=GF PI   zf-DHHC;
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_945 (release 4.0)
#=GF GA   28.70 28.70;
#=GF TC   28.70 28.70;
#=GF NC   28.60 28.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   DHHC_domain
#=GF RN   [1]
#=GF RM   15603741
#=GF RT   Identification of PSD-95 palmitoylating enzymes.
#=GF RA   Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS;
#=GF RL   Neuron. 2004;44:987-996.
#=GF RN   [2]
#=GF RM   23034182
#=GF RT   Analysis of substrate specificity of human DHHC protein
#=GF RT   acyltransferases using a  yeast expression system.
#=GF RA   Ohno Y, Kashio A, Ogata R, Ishitomi A, Yamazaki Y, Kihara A;
#=GF RL   Mol Biol Cell. 2012;23:4543-4551.
#=GF RN   [3]
#=GF RM   26224664
#=GF RT   The canonical DHHC motif is not absolutely required for the
#=GF RT   activity of the yeast S-acyltransferases Swf1 and Pfa4.
#=GF RA   Gonzalez Montoro A, Chumpen Ramirez S, Valdez Taubas J;
#=GF RL   J Biol Chem. 2015;290:22448-22459.
#=GF RN   [4]
#=GF RM   10231582
#=GF RT   The drosophila STAM gene homolog is in a tight gene cluster, and
#=GF RT   its expression correlates to that of the adjacent gene ial. 
#=GF RA   Mesilaty-Gross S, Reich A, Motro B, Wides R; 
#=GF RL   Gene 1999;231:173-186.
#=GF RN   [5]
#=GF RM   12021275
#=GF RT   Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and
#=GF RT   has pro-apoptotic  activity.
#=GF RA   Li B, Cong F, Tan CP, Wang SX, Goff SP;
#=GF RL   J Biol Chem. 2002;277:28870-28876.
#=GF RN   [6]
#=GF RM   16000296
#=GF RT   DHHC9 and GCP16 constitute a human protein fatty acyltransferase
#=GF RT   with specificity for H- and N-Ras.
#=GF RA   Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes
#=GF RA   RJ, Linder ME;
#=GF RL   J Biol Chem. 2005;280:31141-31148.
#=GF RN   [7]
#=GF RM   12370247
#=GF RT   The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl
#=GF RT   transferase.
#=GF RA   Roth AF, Feng Y, Chen L, Davis NG;
#=GF RL   J Cell Biol. 2002;159:23-28.
#=GF RN   [8]
#=GF RM   10490616
#=GF RT   Erf2, a Novel Gene Product That Affects the Localization and
#=GF RT   Palmitoylation of Ras2 in Saccharomyces cerevisiae. 
#=GF RA   Bartels DJ, Mitchell DA, Dong X, Deschenes RJ; 
#=GF RL   Mol Cell Biol 1999;19:6775-6787.
#=GF RN   [9]
#=GF RM   16100337
#=GF RT   The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant
#=GF RT   cell growth in Arabidopsis.
#=GF RA   Hemsley PA, Kemp AC, Grierson CS;
#=GF RL   Plant Cell. 2005;17:2554-2563.
#=GF DR   INTERPRO; IPR001594;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry refers to the DHHC domain, found in DHHC proteins
#=GF CC   which  are palmitoyltransferases [1]. Palmitoylation or, more
#=GF CC   specifically  S-acylation, plays important roles in the
#=GF CC   regulation of protein  localization, stability, and activity. It
#=GF CC   is a post-translational  protein modification that involves the
#=GF CC   attachment of palmitic acid  to Cys residues through a thioester
#=GF CC   linkage. Protein  acyltransferases (PATs), also known as
#=GF CC   palmitoyltransferases,  catalyze this reaction by transferring
#=GF CC   the palmitoyl group from  palmitoyl-CoA to the thiol group of
#=GF CC   Cys residues. They are  characterized by the presence of a
#=GF CC   50-residue-long domain called  the DHHC domain, which in most
#=GF CC   but not all cases is also  cysteine-rich and gets its name from
#=GF CC   a highly conserved DHHC  signature tetrapeptide
#=GF CC   (Asp-His-His-Cys). The Cys residue within  the DHHC domain forms
#=GF CC   a stable acyl intermediate and transfers the  acyl chain to the
#=GF CC   Cys residues of a target protein [2][3]. Some  proteins
#=GF CC   containing a DHHC domain include Drosophila DNZ1 protein  [4],
#=GF CC   Mouse Abl-philin 2 (Aph2) protein [5], Mammalian ZDHHC9 [6], 
#=GF CC   Yeast ankyrin repeat-containing protein AKR1 [7], Yeast Erf2 
#=GF CC   protein [8], and Arabidopsis thaliana tip growth defective 1
#=GF CC   [9].
#=GF SQ   22163
#=GS F9X752_ZYMTI/1-89           AC F9X752.1
#=GS A0A061GXB1_THECC/150-252    AC A0A061GXB1.1
#=GS A0A5N5PRE0_PANHP/60-190     AC A0A5N5PRE0.1
#=GS A0A2K5IUY1_COLAP/153-305    AC A0A2K5IUY1.1
#=GS A0A0C2X147_9AGAM/93-222     AC A0A0C2X147.1
#=GS A0A1E5V1Q9_9POAL/168-298    AC A0A1E5V1Q9.1
#=GS T1IY67_STRMM/64-210         AC T1IY67.1
#=GS R0J0X2_SETT2/126-255        AC R0J0X2.1
#=GS A0A453IDX2_AEGTS/201-330    AC A0A453IDX2.1
#=GS A0A662XSM1_9STRA/120-243    AC A0A662XSM1.1
#=GS A0A2Y9GID1_NEOSC/126-287    AC A0A2Y9GID1.1
#=GS G8YAA2_PICSO/74-206         AC G8YAA2.1
#=GS B4H6D3_DROPE/112-242        AC B4H6D3.1
#=GS A0A1D6EM62_MAIZE/174-314    AC A0A1D6EM62.1
#=GS A0A0E0FB17_9ORYZ/350-457    AC A0A0E0FB17.1
#=GS A0A2H5MX14_CITUN/148-289    AC A0A2H5MX14.1
#=GS A0A086TKP2_9FUNG/231-372    AC A0A086TKP2.1
#=GS M4BKD4_HYAAE/1-139          AC M4BKD4.1
#=GS G1MHW6_AILME/423-559        AC G1MHW6.1
#=GS A0A2Y9P747_DELLE/129-285    AC A0A2Y9P747.1
#=GS A0A0K0DP72_ANGCA/94-239     AC A0A0K0DP72.1
#=GS G0QYL7_ICHMG/149-275        AC G0QYL7.1
#=GS A0A672V1H8_STRHB/99-224     AC A0A672V1H8.1
#=GS F0ULX9_AJEC8/161-285        AC F0ULX9.1
#=GS A0A1D3RIS8_PLAMA/106-232    AC A0A1D3RIS8.1
#=GS A0A3L6QM92_PANMI/107-237    AC A0A3L6QM92.1
#=GS A0A2A2KDT7_9BILA/47-183     AC A0A2A2KDT7.1
#=GS A0A179UPY5_BLAGS/151-304    AC A0A179UPY5.1
#=GS A0A087R672_APTFO/162-295    AC A0A087R672.1
#=GS A0A1R3JUS3_9ROSI/120-263    AC A0A1R3JUS3.1
#=GS A0A177C660_9PLEO/114-238    AC A0A177C660.1
#=GS A0A2U4CPM6_TURTR/160-289    AC A0A2U4CPM6.1
#=GS A0A0K0EWV8_STRVS/115-267    AC A0A0K0EWV8.1
#=GS L8GCE9_PSED2/122-251        AC L8GCE9.1
#=GS A0A0C3F6N8_PILCF/125-257    AC A0A0C3F6N8.1
#=GS A0A0J8QQT9_COCIT/150-275    AC A0A0J8QQT9.1
#=GS A0A383Z6E2_BALAS/136-265    AC A0A383Z6E2.1
#=GS ZDH20_BOVIN/121-247         AC Q0VC89.1
#=GS B7PS34_IXOSC/124-249        AC B7PS34.1
#=GS A0A5K4E974_SCHMA/18-186     AC A0A5K4E974.1
#=GS K1Y8J5_MARBU/421-551        AC K1Y8J5.1
#=GS A0A5D2VKF6_GOSMU/142-273    AC A0A5D2VKF6.1
#=GS A0A0S3SN92_PHAAN/137-267    AC A0A0S3SN92.1
#=GS A0A3P9CA55_9CICH/148-272    AC A0A3P9CA55.1
#=GS A0A4Q4UAN4_9PEZI/152-302    AC A0A4Q4UAN4.1
#=GS A0A565C744_9BRAS/142-273    AC A0A565C744.1
#=GS A0A158NH53_ATTCE/134-302    AC A0A158NH53.1
#=GS B1N5J3_ENTHI/141-273        AC B1N5J3.1
#=GS A0A4C2A4C1_EUMVA/131-262    AC A0A4C2A4C1.1
#=GS M2U4B8_COCH5/153-316        AC M2U4B8.1
#=GS A0A091VNB8_NIPNI/150-289    AC A0A091VNB8.1
#=GS A0A137PGK5_CONC2/54-188     AC A0A137PGK5.1
#=GS A0A4W5PTF5_9TELE/122-277    AC A0A4W5PTF5.1
#=GS A0A3Q3FVE0_9LABR/99-224     AC A0A3Q3FVE0.1
#=GS A0A5E4EAK5_PRUDU/155-306    AC A0A5E4EAK5.1
#=GS A0A103YKR9_CYNCS/377-510    AC A0A103YKR9.1
#=GS A0A3Q4M5N5_NEOBR/99-224     AC A0A3Q4M5N5.1
#=GS G0QPP3_ICHMG/85-222         AC G0QPP3.1
#=GS A0A1U7SUD8_CARSF/85-218     AC A0A1U7SUD8.1
#=GS A0A074W618_9PEZI/177-301    AC A0A074W618.1
#=GS A0A367L6C3_9HYPO/151-299    AC A0A367L6C3.1
#=GS A0A1J9P7F3_9EURO/151-304    AC A0A1J9P7F3.1
#=GS A0A2K5HQ36_COLAP/99-224     AC A0A2K5HQ36.1
#=GS F7D678_MONDO/164-293        AC F7D678.2
#=GS M2NFX2_BAUPA/158-287        AC M2NFX2.1
#=GS A0A5E4NLF0_9HEMI/94-219     AC A0A5E4NLF0.1
#=GS A0A397Z3N8_BRACM/144-275    AC A0A397Z3N8.1
#=GS A0A267EQB0_9PLAT/197-323    AC A0A267EQB0.1
#=GS A0A427YNJ7_9TREE/143-271    AC A0A427YNJ7.1
#=GS A0A5E4F031_PRUDU/151-292    AC A0A5E4F031.1
#=GS A0A316YQP0_9BASI/1068-1211  AC A0A316YQP0.1
#=GS A0A319C4A2_9EURO/402-531    AC A0A319C4A2.1
#=GS A0A384BAT8_BALAS/99-224     AC A0A384BAT8.1
#=GS A0A3Q7FQ35_SOLLC/149-280    AC A0A3Q7FQ35.1
#=GS A0A485PB36_LYNPA/116-260    AC A0A485PB36.1
#=GS A0A1D2MRG9_ORCCI/157-285    AC A0A1D2MRG9.1
#=GS A0A091L4M3_CATAU/85-218     AC A0A091L4M3.1
#=GS A0A078B4X9_STYLE/85-216     AC A0A078B4X9.1
#=GS A0A446QRT9_TRITD/146-261    AC A0A446QRT9.1
#=GS G3ARQ4_SPAPN/53-181         AC G3ARQ4.1
#=GS A0A2Y9M3J1_DELLE/417-553    AC A0A2Y9M3J1.1
#=GS A0A2P6P7Y1_ROSCH/126-255    AC A0A2P6P7Y1.1
#=GS ZD12B_DANRE/97-223          AC E7F021.1
#=GS A0A4V6A947_POPAL/134-264    AC A0A4V6A947.1
#=GS A0A1E3P5T6_WICAA/133-264    AC A0A1E3P5T6.1
#=GS A0A210PHG9_MIZYE/117-243    AC A0A210PHG9.1
#=GS A0A2A3EKM2_APICC/408-547    AC A0A2A3EKM2.1
#=GS A0A4U6UBD0_SETVI/100-239    AC A0A4U6UBD0.1
#=GS A0A445J6R8_GLYSO/120-249    AC A0A445J6R8.1
#=GS A0A452G0R6_CAPHI/468-579    AC A0A452G0R6.1
#=GS A0A6I8WDS6_DROPS/94-219     AC A0A6I8WDS6.1
#=GS A0A670JJL8_PODMU/90-234     AC A0A670JJL8.1
#=GS A0A2H3XYC2_PHODC/365-498    AC A0A2H3XYC2.1
#=GS A0A067E7P0_CITSI/91-124     AC A0A067E7P0.1
#=GS A0A5J4Z3B7_PORPP/131-271    AC A0A5J4Z3B7.1
#=GS A0A1B7MVD6_9AGAM/376-510    AC A0A1B7MVD6.1
#=GS A0A3B0J350_DROGU/124-254    AC A0A3B0J350.1
#=GS A0A3Q3SUY2_9TELE/99-224     AC A0A3Q3SUY2.1
#=GS G0S146_CHATD/364-494        AC G0S146.1
#=GS A0A1D3U8C3_9APIC/207-334    AC A0A1D3U8C3.1
#=GS A0A1U7S0U2_ALLSI/162-291    AC A0A1U7S0U2.1
#=GS A0A2I0B140_9ASPA/72-201     AC A0A2I0B140.1
#=GS A0A2R6QBY7_ACTCC/154-311    AC A0A2R6QBY7.1
#=GS R7T6R7_CAPTE/142-270        AC R7T6R7.1
#=GS C0NMD1_AJECG/393-531        AC C0NMD1.1
#=GS F6PJF9_MACMU/193-322        AC F6PJF9.3
#=GS A0A482WLS1_LAOST/113-255    AC A0A482WLS1.1
#=GS H3CLW6_TETNG/137-267        AC H3CLW6.1
#=GS A0A2R6XRY9_MARPO/157-308    AC A0A2R6XRY9.1
#=GS A0A0K9QCJ4_SPIOL/74-225     AC A0A0K9QCJ4.1
#=GS A0A1V6S2G5_9EURO/150-296    AC A0A1V6S2G5.1
#=GS A0A6Q2Z3Y2_ESOLU/265-401    AC A0A6Q2Z3Y2.1
#=GS A0A445E2I4_ARAHY/102-242    AC A0A445E2I4.1
#=GS A0A6I8TDK2_AEDAE/418-558    AC A0A6I8TDK2.1
#=GS A0A0K9NN50_ZOSMR/373-506    AC A0A0K9NN50.1
#=GS A0A1R3HYK3_COCAP/358-490    AC A0A1R3HYK3.1
#=GS A0A2J8XXU0_PONAB/151-305    AC A0A2J8XXU0.1
#=GS A0A6J3S141_TURTR/126-254    AC A0A6J3S141.1
#=GS A0A3B0J517_DROGU/425-561    AC A0A3B0J517.1
#=GS A0A067JY22_JATCU/120-249    AC A0A067JY22.1
#=GS A0A3Q1BHE7_AMPOC/339-472    AC A0A3Q1BHE7.1
#=GS A0A540MLZ4_MALBA/108-230    AC A0A540MLZ4.1
#=GS A0A2K5S9I6_CEBCA/159-288    AC A0A2K5S9I6.1
#=GS A0A4W4FL77_ELEEL/98-236     AC A0A4W4FL77.1
#=GS J9IA99_9SPIT/82-222         AC J9IA99.1
#=GS A0A3S5WGI8_9MAGN/138-267    AC A0A3S5WGI8.1
#=GS A0A2K6UGU6_SAIBB/99-224     AC A0A2K6UGU6.1
#=GS A0A4Z1L551_9HELO/444-574    AC A0A4Z1L551.1
#=GS I1JCY3_SOYBN/145-276        AC I1JCY3.1
#=GS A0A1R2BY23_9CILI/141-268    AC A0A1R2BY23.1
#=GS A0A137P958_CONC2/220-355    AC A0A137P958.1
#=GS A0A4U5P9T0_STECR/119-264    AC A0A4U5P9T0.1
#=GS A0A6G0WM55_9STRA/367-482    AC A0A6G0WM55.1
#=GS L9JBL0_TUPCH/110-298        AC L9JBL0.1
#=GS J3LIF2_ORYBR/90-216         AC J3LIF2.1
#=GS A0A4S8L3R2_DENBC/111-248    AC A0A4S8L3R2.1
#=GS Q22BC3_TETTS/349-485        AC Q22BC3.3
#=GS A0A0D8XWI6_DICVI/117-218    AC A0A0D8XWI6.1
#=GS A0A2P6SJB5_ROSCH/91-218     AC A0A2P6SJB5.1
#=GS A0A6G0T3S5_APHGL/125-288    AC A0A6G0T3S5.1
#=GS A0A086SVQ4_ACRC1/118-268    AC A0A086SVQ4.1
#=GS A0A446YJF5_TRITD/128-257    AC A0A446YJF5.1
#=GS A0A1J7J075_9PEZI/540-677    AC A0A1J7J075.1
#=GS A0A078AWI7_STYLE/1-123      AC A0A078AWI7.1
#=GS A0A3Q7GZH2_SOLLC/149-280    AC A0A3Q7GZH2.1
#=GS A0A482XR05_LAOST/160-297    AC A0A482XR05.1
#=GS A0A1A0HCI7_9ASCO/166-302    AC A0A1A0HCI7.1
#=GS A0A0K0DYK5_STRER/124-265    AC A0A0K0DYK5.1
#=GS A0A1S3RHA3_SALSA/226-265    AC A0A1S3RHA3.1
#=GS A0A674P685_TAKRU/241-375    AC A0A674P685.1
#=GS A0A072UR39_MEDTR/199-331    AC A0A072UR39.1
#=GS A0A671TNC7_SPAAU/98-156     AC A0A671TNC7.1
#=GS A0A4W4HTN6_ELEEL/115-244    AC A0A4W4HTN6.1
#=GS A0A402FR05_9SAUR/119-244    AC A0A402FR05.1
#=GS A0A3N7GQN0_POPTR/145-186    AC A0A3N7GQN0.1
#=GS A0A3P9BPA2_9CICH/424-560    AC A0A3P9BPA2.1
#=GS W9QV74_9ROSA/160-291        AC W9QV74.1
#=GS A0A017SHY5_9EURO/125-254    AC A0A017SHY5.1
#=GS A0A161V3P3_9PEZI/115-244    AC A0A161V3P3.1
#=GS A0A3R7M6T4_TRYRA/91-227     AC A0A3R7M6T4.1
#=GS A0A2I4AUI6_9TELE/99-224     AC A0A2I4AUI6.1
#=GS A0A5E4NJ28_9HEMI/66-208     AC A0A5E4NJ28.1
#=GS V5DBY9_TRYCR/1-171          AC V5DBY9.1
#=GS A0A1W4XIZ8_AGRPL/84-226     AC A0A1W4XIZ8.1
#=GS A0A1S4DRH6_TOBAC/373-506    AC A0A1S4DRH6.1
#=GS A0A061DC06_BABBI/105-243    AC A0A061DC06.1
#=GS A0A484GNI1_SOUCH/254-388    AC A0A484GNI1.1
#=GS A0A5D2WFS3_GOSMU/173-313    AC A0A5D2WFS3.1
#=GS A0A395NP04_TRIAR/80-213     AC A0A395NP04.1
#=GS A0A341AEE4_NEOAA/115-271    AC A0A341AEE4.1
#=GS A0A653H0W9_9APIC/93-245     AC A0A653H0W9.1
#=GS A0A3Q3B665_KRYMA/98-242     AC A0A3Q3B665.1
#=GS A0A674HDS8_TAEGU/581-718    AC A0A674HDS8.1
#=GS A0DRQ8_PARTE/325-456        AC A0DRQ8.1
#=GS A0A671DHM0_RHIFE/116-240    AC A0A671DHM0.1
#=GS A0A2K5SDC8_CEBCA/187-316    AC A0A2K5SDC8.1
#=GS A0A1A8Z4Y6_9APIC/21-157     AC A0A1A8Z4Y6.1
#=GS M4CJJ6_BRARP/156-296        AC M4CJJ6.1
#=GS A0A182Y9U2_ANOST/1802-1944  AC A0A182Y9U2.1
#=GS F2EJY1_HORVV/146-276        AC F2EJY1.1
#=GS A0A0K3C963_RHOTO/901-1091   AC A0A0K3C963.1
#=GS A0A1D6HFL4_MAIZE/146-197    AC A0A1D6HFL4.1
#=GS A0A445F649_GLYSO/137-267    AC A0A445F649.1
#=GS V9FH20_PHYPR/112-217        AC V9FH20.1
#=GS A0A3Q1FVL0_9TELE/239-373    AC A0A3Q1FVL0.1
#=GS A0A4S4DHQ6_CAMSI/497-629    AC A0A4S4DHQ6.1
#=GS A0A2R6WCS8_MARPO/184-321    AC A0A2R6WCS8.1
#=GS A0A4V6T3Z1_MUSBA/130-259    AC A0A4V6T3Z1.1
#=GS A0A6A2YXZ3_HIBSY/116-247    AC A0A6A2YXZ3.1
#=GS A0A421JP51_9ASCO/1-102      AC A0A421JP51.1
#=GS K5WHI4_PHACS/122-256        AC K5WHI4.1
#=GS A0A0S4J156_BODSA/122-261    AC A0A0S4J156.1
#=GS A0A091SSW7_PELCR/126-255    AC A0A091SSW7.1
#=GS A0A5F9CE31_RABIT/147-276    AC A0A5F9CE31.1
#=GS M4ALB1_XIPMA/95-233         AC M4ALB1.1
#=GS A0A6G0I3R9_LARCR/114-239    AC A0A6G0I3R9.1
#=GS A0A3Q4HZW2_NEOBR/123-250    AC A0A3Q4HZW2.1
#=GS A0A453NGX4_AEGTS/157-290    AC A0A453NGX4.1
#=GS A0A078B796_STYLE/222-273    AC A0A078B796.1
#=GS A0A1R2CI24_9CILI/116-243    AC A0A1R2CI24.1
#=GS A0A1J9QBK8_9EURO/151-304    AC A0A1J9QBK8.1
#=GS A0A026WEE2_OOCBI/84-216     AC A0A026WEE2.1
#=GS T1F1D2_HELRO/284-422        AC T1F1D2.1
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