GenomeNet

Database: Pfam
Entry: DUF16
LinkDB: DUF16
Original site: DUF16 
#=GF ID   DUF16
#=GF AC   PF01519.19
#=GF DE   Protein of unknown function DUF16
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_764 (release 4.0)
#=GF GA   30.40 30.40;
#=GF TC   30.40 30.90;
#=GF NC   30.30 30.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   8948633
#=GF RT   Complete sequence analysis of the genome of the bacterium
#=GF RT   Mycoplasma pneumoniae. 
#=GF RA   Himmelreich R, Hilbert H, Plagens H, Pirkl E, Li BC, Herrmann R; 
#=GF RL   Nucleic Acids Res 1996;24:4420-4449.
#=GF RN   [2]
#=GF RM   16522803
#=GF RT   Crystal structure of the DUF16 domain of MPN010 from Mycoplasma
#=GF RT   pneumoniae. 
#=GF RA   Shin DH, Kim JS, Yokota H, Kim R, Kim SH; 
#=GF RL   Protein Sci. 2006;15:921-928.
#=GF DR   INTERPRO; IPR002862;
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   The function of this protein is unknown.  It appears to only
#=GF CC   occur in Mycoplasma pneumoniae. The crystal structure revealed
#=GF CC   that this domain is composed of two separated homotrimeric
#=GF CC   coiled-coils [2].
#=GF SQ   36
#=GS Y501_MYCPN/39-113         AC P75286.1
#=GS Y524_MYCPN/40-125         AC P75254.1
#=GS A0A1M6CJZ4_9CLOT/2-77     AC A0A1M6CJZ4.1
#=GS Y410_MYCPN/39-146         AC P75374.1
#=GS Y287_MYCPN/2-116          AC P75490.1
#=GS Y100_MYCPN/110-181        AC P75592.1
#=GS Y655_MYCPN/97-195         AC P75136.1
#=GS A0A0Q5TCD4_9BACT/2-121    AC A0A0Q5TCD4.1
#=GS Y010_MYCPN/37-130         AC P75103.1
#=GS Y010_MYCPN/37-130         DR PDB; 2BA2 C; 205-285;
#=GS Y010_MYCPN/37-130         DR PDB; 2BA2 A; 5-85;
#=GS Y010_MYCPN/37-130         DR PDB; 2BA2 B; 106-185;
#=GS Y484_MYCPN/2-102          AC P75301.1
#=GS Y504_MYCPN/39-125         AC P75282.1
#=GS A0A559KC87_9BACL/17-100   AC A0A559KC87.1
#=GS Y137_MYCPN/43-170         AC P75261.1
#=GS Y104_MYCPN/3-103          AC P75565.1
#=GS Y130_MYCPN/39-139         AC P75345.1
#=GS Y013_MYCPN/179-256        AC P75100.1
#=GS R9MH93_9FIRM/34-128       AC R9MH93.1
#=GS A0A4Z0R8R3_9FIRM/8-75     AC A0A4Z0R8R3.1
#=GS Y138_MYCPN/39-157         AC P75260.1
#=GS Y344_MYCPN/86-194         AC P75434.1
#=GS Y100_MYCPN/39-114         AC P75592.1
#=GS A0A4R1QQV7_9FIRM/119-190  AC A0A4R1QQV7.1
#=GS A0A5M6CFR4_9BACT/3-80     AC A0A5M6CFR4.1
#=GS Y139_MYCPN/39-154         AC P75259.1
#=GS Y204_MYCPN/39-146         AC P75572.1
#=GS Y151_MYCPN/2-110          AC P75035.1
#=GS Y094_MYCPN/39-139         AC P75598.1
#=GS Y368_MYCPN/39-157         AC P75413.1
#=GS Y501_MYCPN/110-167        AC P75286.1
#=GS Y127_MYCPN/77-166         AC P75348.1
#=GS Y038_MYCPN/29-115         AC P75076.1
#=GS Y013_MYCPN/108-216        AC P75100.1
#=GS Y283_MYCPN/40-115         AC P75494.1
#=GS Y145_MYCPN/37-164         AC P75141.1
#=GS A0A4R2RZD1_9FIRM/82-156   AC A0A4R2RZD1.1
#=GS A0A4Z0R8R3_9FIRM/66-155   AC A0A4Z0R8R3.1
Y501_MYCPN/39-113                    ..........................................EFSG..KFNRQFKLnkpvIPVNTEYVTRKEFNE....YKNS..........NDQRLTKIETTLA..................AQGEQINKLTQTVEKQGEQINQLVQ----------..............-------------------------vv..........................
Y524_MYCPN/40-125                    ...................................elrkykl----..------KP....-PVKVKYVTQEQFQE....YKDS..........NNQRLIKIETTLA..................AQGEQI-------RIQVEQIKELQIEQKAQGE---..............----TLKLILQTLQKMSDRLDKME-v...........................
A0A1M6CJZ4_9CLOT/2-77                .......................................tdq----..--------....---------------....---D..........LQHTLNQIVGMID..................TLGKKIDRLEEKVDRIEERLDRIEERLDRVEERLD..............RVEERLDRVEERLDRVEARLDSLE-............................
Y410_MYCPN/39-146                    ..........................................EFSG..SFNRQFKLnkpiIPVNTEYVTRKEFNE....YKDS..........NDQRLIKIETTLT..................AQGEQINKLTQTVEKQGEQIRELQVEQKAQGEQIK..............AQGETLKLILQTLQKMSDRLDKID-p...........................
Y287_MYCPN/2-116                     .........................................g-FSD..NLNHMEKR....---KSGYVTQKQFSE....FKDA..........NNQRLIKIETTLA..................TQGEQLNQLIKVVILQGEQIKELQVEQKAQGEQIKakgeqikaqseqikTQGETLKLILQALGGINKRLDKVD-p...........................
Y100_MYCPN/110-181                   .......................................vqv----..--------....---------------....----..........-----------VL..................LHGEQINKLTQTVEKQGEQIKELQVEQKAQGEQIKaqg.......kqikAQGKTLKSILQALGGINKRLDKID-p...........................
Y655_MYCPN/97-195                    .......................................qpg---GpdNPNAGNKK....MPTPEEYVTRKEFNE....FKDS..........NNQRLTKIENKVD..................KLEVKVDKLAEIVQTQGEEIKELKVEQKAQSE---..............----TLQLILKTLQKMNDRLDRMET............................
A0A0Q5TCD4_9BACT/2-121               yieeridlaeislvehgkqiemiatglatlttlvytgfaemr----..--------....---------------....----..........--EEFVQVHKRID..................NLEIRFNKLEDKVDRLEIRIDRLEVRLDKVEARLD..............KVEERLDKIEERLDKIEERLDKIE-arldnles....................
Y010_MYCPN/37-130                    .........................................w-LKG..VFEEIVKT....-P-GTRYVTHKQLDE...kLKNF.........vTKTEFKEFQTVVM..................---ESFAVQNQNIDAQGEQIKELQVEQKAQGK---..............----TLQLILEALQGINKRLDNLES............................
#=GR Y010_MYCPN/37-130         SS    .........................................X-XXX..XXXXXXXX....-X-XTTB-BHHHHHH...HHTTB.........-BHHHHHHHHHHHH..................---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---..............----HHHHHHHHHHHHHHHHHHHC-............................
Y484_MYCPN/2-102                     .........................................g-FYG..NLNHMEKR....---KSGYVTQKQFND....FKNS..........NNQRLIKIENTLV..................SQGEQISQLIKVSILQGEQINKLTETVEKQGEQIQ..............TQGETLKLILETLQVINKRLDRLES............................
Y504_MYCPN/39-125                    ..................................yelrkykl----..------KP....-PVKVKYVTQEQFQE....YKDS..........NNQRLIKIENKVD..................-------KLVEIVQIHGEQI-------KAQGE---..............----TLQLILQTLQKMSDRLDKME-kridkles....................
A0A559KC87_9BACL/17-100              .......................................lsh----..--------....-----------DLSE....FRIE..........VDQRFAGLEHRMD..................RLEERMVKLEARMDRLEERMVKLEARMDRLKERME..............KLEERMNKLEERMSKLEERMDRL--ge..........................
Y137_MYCPN/43-170                    .........................................s-FNG..DFEVVTKK....-P-STKYVTHKQLDQklkeFKQDlmvelhdtfaTKADLRDSEARINqklea.......lvqvvlLHGEQINKLTQIVEKQGEQIRELQVEQKAQRQEFN.............aRMDRLENLLVESIESTNKRFDSIEG............................
Y104_MYCPN/3-103                     ....................................eldgkf----..--------....---------------....---A..........TKADLKRVEDKVDvlfelqk....tqgeqikVQGKQIEQLTETVQKQGEQIKELQVQVKAQGEEIKeik.......veqkAQGQTLQLILKALEGINKRLDNLES............................
Y130_MYCPN/39-139                    ..........................................EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLIKIETTLA..................AQGEQ-------IRIQGEQIKELQIEQKAQSE---..............----TLKLILQTLQKMSDRLDKMD-vrldkles....................
Y013_MYCPN/179-256                   ........................................kq----..--------....---------------....----..........----IEQLTETVK..................VQGEQIRAQGEQIKAQSEEIKEIKVEQKAQGEQIKelq.......veqkAQGKTLQLILKTLEKMNERLEKLES............................
R9MH93_9FIRM/34-128                  ..................................leekldak----..--------....------------LQF....YMEK..........TNQRFDKLENKVE..................KVGQRLDSLEEKVEKVEQRLDSLEEKVEKVEQRLDsle.......ekveKVEQRLDSLEEKVEKVEQRLDSLE-e...........................
A0A4Z0R8R3_9FIRM/8-75                .................................ekilqaieg----..--------....---------------....LKND..........MDHKFDKLSEKVD..................NQGSQIDKLSEKVDNQGSQIDKLSEKVDNQGSQID..............KLSEK--------------------vd..........................
Y138_MYCPN/39-157                    ..........................................EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIENKVD..................KLEVKVDKLEEKVDKLEAKVDKLEEKVDKLEAKVDkleek...vdkleaKVDSGFEMLAKILAAINKRLDSIEG............................
Y344_MYCPN/86-194                    ....................................qpggpd----..DPNSGNKK....MPKPDEFVTHRQLQE....FKKDllvelheifpTKPELKRVEEKVD..................VLFELQKAQGEQIRIQGEQIKELKVEQKAQGE---..............----TLQLILQTLQKMNDRLDKIEG............................
Y100_MYCPN/39-114                    ..........................................EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKVS..........NDQRLTKIETTLA..................AQGEQINKLTQTVEKQGEQINQLVQ----------..............-------------------------vvl.........................
A0A4R1QQV7_9FIRM/119-190             ......................................evkv----..--------....---------------....----..........-----DSLEAKVG..................SLETKVDSLETKVDSLETKVNSLETKVDSLEVKTN..............GLIEDMDIIKPSLVKMSNRLDNIEG............................
A0A5M6CFR4_9BACT/3-80                ......................................kvcr----..--------....------------FKE....WVNR..........LKGRVNRLEERVN..................KLEERVNRLEERVNKLEERVNRLEERVNRLEERMN..............RLKERVNGLEERVNK----------lrpp........................
Y139_MYCPN/39-154                    ..........................................EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIETELK..................SQGQRIQVVEDKVDRLTEVVMVQSQQIKTQGEAMNarmd......rfesLVLKSLESIGNTLTDFGKRLDVIET............................
Y204_MYCPN/39-146                    ..........................................EFSG..KFNRQFKLnkpvITVNTEYVTRKELNE....YKDS..........NDQRLTKIETTLA..................AQGEQINKLTQTVEKQGEQIRELQVEQKAQGEQIK..............AQGETLKLILQTLQKMSDRLDKID-p...........................
Y151_MYCPN/2-110                     ..........................................EFNG..NLNHMEKR....---KSGYVTQKQFNE....YKDS..........NDQRLIKIETTLA..................AQGEQISQLVQIVFLQGKQIKELQAEQKAQRVEFNarmd......rfesLVLKSLESIGNTLTDFGKRFDSMET............................
Y094_MYCPN/39-139                    ..........................................EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIETTLA..................AQGEQ-------IRIQGEQIKELQIEQKAQGETLK..............LILQTLQKMSDRLNKMDVRLDKLE-s...........................
Y368_MYCPN/39-157                    ..........................................EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIENKVD..................KLEIKVDKLEKKVDKLEVKVDKLVETVNAQGEDLNnfkve...vrgtlqSQGETLQLILQTLQGMSKRLDSVEG............................
Y501_MYCPN/110-167                   .......................................vqv----..--------....---------------....----..........-----------VL..................LHGEQINKLTQTVEKQGEQIKELQIEQKAQGE---..............----TLKLILQTLQKMSDRLDKME-v...........................
Y127_MYCPN/77-166                    .........................................g-FNG..NFNHMEKR....---KSGYVTQKQFSE....FKDA..........NNQRLIKIETTLA..................IQGEQINKLTQTVEKQGEQINQLVQVVLLQGA---..............-------------------------sklenfkwskkhkdksl...........
Y038_MYCPN/29-115                    .........................................g-FHG..NLNHMEKG....---KSGYVTHKQLDKklevFKQ-..........---DL-----LVE..................-LSEKF-VTKEEFRAQGKQIKELQIEQKAQGK---..............----TLQLILEALQGINKRLDKLES............................
Y013_MYCPN/108-216                   ..................................pggpddps----..---EGKQK....VSKPDKYVTHRELDE...kLK-Df........aTKADFKRVEDKVDvlf...........elqkTQGEQIKVQGEQIKAQGKQIEQLTETVKVQGEQIR..............AQGEQIKAQSEEIKEI---------kveq........................
Y283_MYCPN/40-115                    ...................................elrkykl----..------KP....-PVKVKYVTQEEFGE....FKDA..........TNQRLTKIENALV..................AQGEQIRAQGEQLSQLIKVVLLQGEQIKSQGEQIK..............-------------------------s...........................
Y145_MYCPN/37-164                    .........................................s-LNG..VFEEIVKT....-PGKTRYVTHKQLDQklkdFKQDlmvelhdtfaTKTDLKESEARINqklealiqivmvqgeqikVHGEQINKLTQAVEKQGEKI-------EAQGQQIQ..............KVNETLNFVVESLGSIHKRLDSMEG............................
A0A4R2RZD1_9FIRM/82-156              .......................................dkv----..--------....---------------....----..........-EERLSKVEGRLD..................KVEERLNKMDERFDKVEERLDKMDERFDKVEERLD..............KMDERFDKVEEQFDKMDERFDQMDG............................
A0A4Z0R8R3_9FIRM/66-155              ........................................qi----..--------....---------------....----..........-----DKLSEKVD..................NQGSQIDKLSEKVDNQGSQIDKLSEKVDHQGSQIK..............ENTQILKAL-EHLAQVNK-------aehdkmsfniaeisgeikairkdlsnve
#=GC SS_cons                         .........................................X-XXX..XXXXXXXX....-X-XTTB-BHHHHHH...HHTTB.........-BHHHHHHHHHHHH..................---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---..............----HHHHHHHHHHHHHHHHHHHC-............................
#=GC seq_cons                        ......................................................K.........stYVTpcphp-....aKps..........spp+Lp+lEspls..................spGEplspLpppVcpQGEQIccLp.c.csQGEphp..............h..psLphlhppLpphscRLDph-.............................
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