#=GF ID   DUF2105
#=GF AC   PF09878.12
#=GF DE   Predicted membrane protein (DUF2105)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4036)
#=GF GA   32.00 32.00;
#=GF TC   186.90 186.70;
#=GF NC   27.40 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019212;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   29
#=GS F0T706_METLA/12-216      AC F0T706.1
#=GS A0A483CSM2_9EURY/1-193   AC A0A483CSM2.1
#=GS O26490_METTH/28-230      AC O26490.1
#=GS Q2FMA3_METHJ/1-194       AC Q2FMA3.1
#=GS F6BBE1_METIK/6-226       AC F6BBE1.1
#=GS D7DQX1_METV3/6-234       AC D7DQX1.1
#=GS I7J8L6_METBM/1-194       AC I7J8L6.1
#=GS D3E3Z5_METRM/14-218      AC D3E3Z5.1
#=GS A0A166EWV1_9EURY/14-218  AC A0A166EWV1.1
#=GS A0A1V6N3S1_9EURY/13-227  AC A0A1V6N3S1.1
#=GS A0A0X3BKU0_9EURY/1-194   AC A0A0X3BKU0.1
#=GS A0A328PCY4_9EURY/15-219  AC A0A328PCY4.1
#=GS A0A1D2W5X6_9EURY/16-220  AC A0A1D2W5X6.1
#=GS R9SK99_9EURY/11-218      AC R9SK99.1
#=GS Q8TY35_METKA/11-210      AC Q8TY35.1
#=GS A0A366MC80_9EURY/12-226  AC A0A366MC80.1
#=GS A0A1D3L1L1_9EURY/11-219  AC A0A1D3L1L1.1
#=GS Y523_METJA/8-231         AC Q57943.1
#=GS A0A498GXT1_9EURY/1-195   AC A0A498GXT1.1
#=GS A0A166EFG5_9EURY/12-216  AC A0A166EFG5.1
#=GS A0A133ULH3_9EURY/1-198   AC A0A133ULH3.1
#=GS A0A166AXB5_9EURY/11-215  AC A0A166AXB5.1
#=GS A2SQY4_METLZ/8-202       AC A2SQY4.1
#=GS U6ED85_9EURY/15-219      AC U6ED85.1
#=GS A6UTX8_META3/3-246       AC A6UTX8.1
#=GS E1RDK2_METP4/6-199       AC E1RDK2.1
#=GS A0A2U1S9G7_9EURY/12-224  AC A0A2U1S9G7.1
#=GS H1Z138_9EURY/1-194       AC H1Z138.1
#=GS Q6LX98_METMP/4-227       AC Q6LX98.1
F0T706_METLA/12-216                 .vv--GLYAPAIIVGILVGLIGLFGISV....EKNDLQVLILTDIVGIGMLIFVAAVGTDLAESLILPGLVVELAEIMAISEILMSREMRKSGkt....velIPTPLH...............................FNLEILQTAPIFLAIILIVYGAFLSGFTGGAIAGAGILFYVMSMKVRGVPSG......VWEGLAGVSGIAWCLWLVGFLVLFVFPQYWLLGLMLAAF.GVFIKVAFKAGLIGVM-n.
A0A483CSM2_9EURY/1-193              mts----YWIVLTIVLIATAIAFSALLR....ENDDLHRLLLTDLAEIVGLTIIALVATDLAEALILPGLVVGISELMALSEVYLVKEGLKQA.........-P-ERL...............................MHLEIMDSAPAILAAVLVVYGIILSGFSGGAVAGTGLLFWFFCKGHDE----......AFALIETASGYAWVLWIAAFFIFMIAPSYWLFAVMVAGG.AILLKVMAKMALVGTM-r.
O26490_METTH/28-230                 .tl--SLFQPAIYTGLIAGFIALLGISF....QKNDLSALIITDIVGIAMLVIVAAVGTDLAEALILPGLVVELAEIMAISEILISREMRILGe......vpVVEHRP...............................MELEVFRTAPNFLALILIAYGVFLTGFTGGAVAGAGILFYVATRRARGLPTV......EWDGIAGISGVTWCLWLAGFLIFFTAPQLWLPALFMSGC.GILIKVASKMGLIGVL-a.
Q2FMA3_METHJ/1-194                  ...MMDFYQIGLLCTLICVTISFIALFR....ERDDIHKILVVDLIETTGLVLICLVATDLAEALILPGLVVGISELLMLTELYIRKEKLP--.........LPAYKP...............................IRIEVMRTAPPIITFALVVYGIILSGFSGGAVAGIGLVFYFLCKGYEE----......RFALLETISGYAWALWIVAFFIFMILPQAWLIAVMLSGG.AILVKVTTKMALIGTM-q.
F6BBE1_METIK/6-226                  ..i-YSFYNPSILVAFIVGILSLFALSY....QKSDLHILLLTDLIECAMLVVIAAVGTDLAEALILPGLVVGMAELLAVSEILVMKKSLAKN.........KPKKKLfeefllpl...............hhgvleheVEMEILKTSPKFLALVLVVYGAILSGFTGGAIIASGLLYYALSQRALGREFDet.ikcLWEGISGLSGIAWALWIFGFIGFFINPDNYLVWLMLAGL.GLVIKVGSKLGLIGYI-g.
D7DQX1_METV3/6-234                  ..v-SMFYSNSIIVGIIVGVISLYAISR....EKWDVNMIILSDVVELAMLIIVASVGSDLAEALILPGLVVGMAELLAVSEIYISRKNIADEk.......iTCKSKSrksklleeft..........ikgspnlnvefTKMQILKTSPKFIAVVLIIYGAILSGFTGGAVMASGLIYYLLSKRVIGEKISkadflnIWDGFISFSGIAWALWVLGFLGFFIMPSKWSVFLLIAAL.GLVLKVGSKLGLIGQV-w.
I7J8L6_METBM/1-194                  mip---AYPLGLLVAFASAGIAFFALMR....ETDGLHRLLLTDLVEVVTLAFIALVGTDLAEALILPGLVVGVSELIALSEIFRIKEGYT--.........RPPTDT...............................LQIEVMKTAPPILAALLVGYGIVLSGFSGGAVAGLGVIFYFLSRNPSE----......RFEVIETASGYSWILWIVAFFTFMILPQYWFFAVMLAGS.AILVKVMAKMSLIGTM-r.
D3E3Z5_METRM/14-218                 ..y-SSMYTTALYGGLIVAFIGLIGVAM....EKRDIQILILTDIVGLAMLIVVAAVGTDLSEALILPGLVVELAEIMAISEILISREMRKADkd....tsfSPMPLD...............................IDMEIMTTAPNFIALLLIGYGIFLSGFTGGAVAGGGIVIYVLSRKVRGLPIF......VLDGVGAISGISWCLWIIGFIFFFILPQYWLLSLFLAAL.GLLLKVASKIGLIGILM..
A0A166EWV1_9EURY/14-218             .fl--SWYAPAVYTGFIVAFIGLMGIAI....AKKDIHILILTDIVGLSMLVVVGATGTDLAEALILPGLVVELAEIMAISEILVSREMRKNNgs....sslLPLPIV...............................SDMEIMTTAPNFLSLVLIGYGVFLTGFTGGAVAGAGILLYIFSKKSRGLPVL......VIDGIGAVSGLAWCLWIVGFLLFFIAPEYWLLSLFMAAC.GLLLKVASKLGLIGTLM..
A0A1V6N3S1_9EURY/13-227             ..t-ASLYLPALYVAILIGFIGLTGIAI....QKRDIHILILTDLVGLAMLIVVAAVGTDLAEALILPGLVVELAEIMAISEILISREMRKAE.........NSVPKDrtitekp................svfplplsLDMEIMKTAPNFIALVMILFGAFLTGFTGGAVAGGGILFYMMCKKARGLPVF......VVEGIGAISGISWCLWIVGFVLFFLAPQYWLLSLFMAAC.GLVLKVASKLGLIGSI-l.
A0A0X3BKU0_9EURY/1-194              mip---AYPLGLLVAFASAGIAFFALMR....ETDGLHRLLLTDLVEVVTLAFIALVGTDLAEALILPGLVVGVSELIALSEIFRIKEGYT--.........RPPTDT...............................LQIEVMKTAPPILAALLVGYGIVLSGFSGGAVAGLGVIFYFLSRNPSE----......RFEVIETASGYSWILWIVAFFTFMILPQYWFFAVMLAGS.AILVKVMAKMSLIGTM-r.
A0A328PCY4_9EURY/15-219             ..i-VNFYPIAIIIAILTAAIGLSGVII....ERDDFQKILIIQIVTYAMLIIVAAVGTDLAEALILPGLVVSLAEILAVTEVLIFREYTKRGts....yprLKKYKP...............................IDMEVLKTAIPMTSLLCVVYGTILTGFTGGAVAGAGILIYLFIGEPKGLSTD......FWEEMSGVSGLAWCLWLLGFLLYFLNPRLWLVALFMSGG.GIIIKVALKFGLLGIL-n.
A0A1D2W5X6_9EURY/16-220             ..v-VSLYQPAILVGLLTGFIGLLGIAF....KKGDLTALILTDIVGFAMLIIVAAVATDLAEALILPGLVVELAEILAISEVLMSREMRKTGks....vdlIPLPLS...............................LDMEILETAPAFLAIILIAYGAFLSGFTGGAVAGTGILFYVLSRTIRGVPSS......IWEGVAGISGVAWVLWLIGFLMFFVTPQYWLLALFLSAF.GVLIKVASKVGLIGVL-g.
R9SK99_9EURY/11-218                 ..y-ANMYLPAFYTAIIVGFFTCIAIAM....QKRDIHVLILTDLIGFAMIIVVAGVGTDLAESFILPGLVVELAEIMAISEILISREMRKISsnqp.nvsfAPMPMD...............................YNMEILTTAPNFLSLILLAYGVFLTGFTGGAVAGGGILLYILSRKARGLPVL......ELNGISGISGLGWCMWIISFWLFFTMPQYWLLCLFLAAC.GLLLKVATKMGLIGVLM..
Q8TY35_METKA/11-210                 ..t-VKMYHVAVAAGIAVGLIAAVDIAA....DRNPLNRLTMTDALEVGSLTLLASVGTDLAECLILPGLVVGLAELIATAEVLVARYTDGDS.........LPEFEP...............................LDMEVLRTAPTAIMIGLVVYGVLLTGFTGGAVAGSGAAFYLFSRANRPHY-E......EWRGMESISGIGWAFWVAGFSTFFLHPKAWLLALILAGTgGILVKVGPKLTLLGYA-m.
A0A366MC80_9EURY/12-226             ..t-ASLYLPAVYLAMIVGFLGLTGIAI....QKKDIHILILTDLVGLAMLIMVAAVGTDLAEALVLPGLVVELAEIMAISEILISREMRKIEnae...pidR----Viarkhs..................vfpfplkLDMEIMTTAPNFIALVMILYGAFLTGFTGGAVAGGGILFYIFSRKARGLPVI......VIDGIGAISGFSWCLWIIGFVLFFIAPQYWLLLLFMAAC.GLFLKVASKLGLIGAMM..
A0A1D3L1L1_9EURY/11-219             ..v-VALYTPAVIVGIVAGLIGLLGISF....EKNDLHILILTDLVGIAMLVIVAAVGTDLAESLILPGLVVELAEILAISEVLMSREMRKNGtkegkhvplIPLPMK...............................MDMEVLHTAPVFISVILIAQGAFMSGFTGGAVAGAGILFYVLSRTVRGVPSG......MWEGIAGASGIAWCFWLAGFMVFFVFPQYWLLALFLAAF.GIFIKVTFKAGLIGVL-g.
Y523_METJA/8-231                    ..i-YSIYHPTILVGFAIGILSLLAIGF....QKNDLHALILTDVVECAMLIIIAGVGTDLAEALILPGLVVSLAELLAVSEVLITRKYLKSK.........RPKPKSyklfeefkl............plytgelkydIHMEILKTSPKFLAIILIVYGAILSGFTGGAVIATGLLFYALSQRVIGVEISee.lktMWEGISGLSGIAWALWIFGFIGFFVFPDKWLLCLLMAGL.GLVIKVGSKLGLIGYI-g.
A0A498GXT1_9EURY/1-195              ..m-DLVYSLGLLVVFLGIIVGFYALMR....ERDDLHRILLTDLAEILALALIALVATDLAEALILPGLVVGISELLAVSEVYLAKEELRTP.........-PVAPP...............................LRIEVMESAPGIMALILVTYGIVLSGFTGGAIAAVGALFYYLCKGHDE----......RFDLIETVSGYAWVFWIGAFFIFMFLPAYWFFGVMIAGG.AILVKVMAKMSLIGTM-r.
A0A166EFG5_9EURY/12-216             .fa--SWYVPAIYAGIIIAFIGLIGIAI....QKRDIHILILTDIVGLAMLIFVAAVGTDLAEALILPGLVVELAEILAISEILISREMRKSNkq....sslLPLPMV...............................LDMEIMTTAPNFLVLVLLAFGAFLTGFTGGAVAGGGILLYIISRKSRGLPIA......EIEGIGGVSGIAWCLWIIGFVLFFIAPDLWLLSLFMAAC.GLVLKVASKIGLIGAM-i.
A0A133ULH3_9EURY/1-198              .mi--------VTLGAIYGGIAAAGFAV....QKKDVHKLIMGEAATLVSLAIIAAVGTDLAEALILPTVVVMVAETLAFSEILVEKEKKKIGis.....elPKIDRE...............................IGLEIMETSPVLISGGLIIYGAILTGFQGGAVVGVGALYYLITKWDGEISPQ......LWDISSSIGGIGWSWWMIGFAIIFLLPKFWMLGLFLAAT.GILIKVGSKMQLLGV--ev
A0A166AXB5_9EURY/11-215             .fa--SWYMPAIYTGFIIAFVGLIGIAV....PKRDIHVLILTDIIGLAMLVIVGAVGTDLAEALILPGLVVELAEILAISEILISREMRKKDki....pslFPTPLT...............................LDMEIMTTAPNFLAIVLIGYGVFLTGFTGGAVAGSGILVYIFSRKVRGLPIL......IIDGIGAVSGISWCLWIIGFFLFFVTPQFWLLSLFLAAC.GLLLKVASKMGLIGVLM..
A2SQY4_METLZ/8-202                  ..m-DLIYKIGLAVAFIAIIVAFSAVVR....ERDEISLLIIIDLIEITGLVVIALLATDLAEALILPGLVVGVAEIMAVSELWLVKEGLQNV.........RPVRR-...............................LDIEVLHTAPPIIGALLTAYGIFLTGFTGGLIAGLGLALFFLGKATTE----......NFLSSENASGYAWVLWVLAFLIFILFPSQWFLALMAAAV.GIMIKVMAKIALVGTM-r.
U6ED85_9EURY/15-219                 ..v-VSLYLPAIVTGLLVGIIGLLAISY....QKNDLSALILTDIVGIGMLIMVAAVGTDLAEALVLPGLVVDLAEILAISEILMNREIRKKGkd....vdlIPLPLK...............................MDMEILTTAPTFLAIILVAYGAFLSGFTGGAVAGGGILMYVLSKRMRGVPSD......TWEGVAGVSGIAWCLWLVGFVIFFAFPQFWLLALFLAAF.GVFIKVTFKMGLIGVM-g.
A6UTX8_META3/3-246                  ..i-TLLYNSTVFTGFIVGILSLFAISSsgknNNSDLDMVIYTNIVECAMVVIIAAVGTDLAEALILPGLVIGMAELLAVSEVLVNRNEHRQKdke..iieiN----QrynlinknnikqhklleeflakdeahakisiNKMEVLYTAPKFMAIVLVVYGAILTGFTGGAVIACGLLFYLLSQRVLEKEVPfpklkvYWEGISGFSGIMWAIWIFGFIGLYLFPQHYIYFLLIAGC.ALALKVGSKLGLMGDL-l.
E1RDK2_METP4/6-199                  .ls--SEYELALIITLVCVIIAFWAMVR....EKEDLHRLILTDLVEIMSLVIIALVATDLAEALILPGLVVGIAELLALSELYIEKENLRKD.........--PENV...............................LHIEVMDSAPGILAVIFVIYGIILSGFTGGAVAGLGLVFYFMCRGSSE----......KREIIETVSGYAWACWVVAFIVFMALPQYWFFGVIIAGA.GIFAKVAAKMSVIGTM-n.
A0A2U1S9G7_9EURY/12-224             .fl--SMYLPAIYAGLIIGFIGTMAIAM....KREEIHILILTDIVGLAMLVVVSAVGTDLAEALVLPGLVVELAETLAISEILLSREMHKIE.........ANPKKNlsptss..................lfptsftLNMEIMTTAPNFIALVLIGYGIFLTGFTGGAVAGGGMVLYALSRKIRGLPVF......VLDGVGAISGIAWCCWIIGFALYFVMPELWLLSLLLSAF.GLLLKVASKVGLIGVLM..
H1Z138_9EURY/1-194                  ...MDQTYFLGITVIFAASAIVFMALFK....EKNDLHRLILTDLAEIAALALIAMVATDLAEALILPGLVVGISELLAISEIYLVREGLT--.........KPVRRK...............................FRLEIMDSAPAIMALVLVAYGIVLSGFSGGAVAATGAVFFFMCRGSVE----......RFEILEIVSGYAWAFWIAAFFIFMVLPQYWFFAVMLAGG.AILVKVMAKMSLIGTM-g.
Q6LX98_METMP/4-227                  ..v-SLLFSKTVAVGFIVGIISLYSISR....QKSDLNMILLTDLIEYGMLVIIAAIGSDLAEALILPGLVVGMAELLAVAEIFVSRNDLRKE........gKPKKSKlleefmik..............etpkmdinfSKMEVLYTTPKFLAVILVIYGAILSGFTGGAVMASGLLFYVLSKRVLGKKILpeelkvSWEGISAFSGIAWAIWILGFIGFFLFPSKWPYFLIIAGF.GLAIKVGSKLGLIGEL-f.
#=GC seq_cons                       ..h..shY.sulhluhlsuhIuhhuluh....pKsDlHhLILTDlVtluMLlllAuVGTDLAEALILPGLVVtlAEllAlSEILlsREhh+ps.........hPh.hs...............................lcMElhcTAPsFlAllLlsYGshLoGFTGGAVAGsGlLaYhlS+pscGh.........ha-GluulSGlAWsLWIlGFhlFFlhPpaWLluLhlAus.GlllKVuuKhGLIGsh.h.
//