#=GF ID   DUF22
#=GF AC   PF01629.19
#=GF DE   Domain of unknown function DUF22
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1137 (release 4.1)
#=GF GA   25.00 25.00;
#=GF TC   25.00 33.50;
#=GF NC   21.70 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR002572;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain is found in 1 to 3 copies in archaebacterial
#=GF CC   proteins.  The function of the domain is unknown. This family
#=GF CC   appears to be expanded in Archaeoglobus fulgidus.
#=GF SQ   60
#=GS W9DV09_METTI/5-110        AC W9DV09.1
#=GS D3S2H3_FERPA/2-88         AC D3S2H3.1
#=GS A0A133UP75_9EURY/2-107    AC A0A133UP75.1
#=GS E3GX44_METFV/2-107        AC E3GX44.1
#=GS A0A1F2P6H3_9EURY/2-110    AC A0A1F2P6H3.1
#=GS Y614_METJA/6-110          AC Q58031.1
#=GS O27033_METTH/2-108        AC O27033.1
#=GS A0A328P9S0_9EURY/2-109    AC A0A328P9S0.1
#=GS D3S2H3_FERPA/262-368      AC D3S2H3.1
#=GS Q8TUS8_METKA/2-106        AC Q8TUS8.1
#=GS A0A366MEH9_9EURY/13-107   AC A0A366MEH9.1
#=GS D7E7T8_METEZ/5-110        AC D7E7T8.1
#=GS N0BBU2_9EURY/287-390      AC N0BBU2.1
#=GS N0BBU2_9EURY/2-106        AC N0BBU2.1
#=GS O28745_ARCFU/2-110        AC O28745.1
#=GS D7E6H5_METEZ/5-110        AC D7E6H5.1
#=GS U6EE75_9EURY/1-106        AC U6EE75.1
#=GS A0A0F7IFV3_9EURY/149-254  AC A0A0F7IFV3.1
#=GS A0A4E0Q7B8_9EURY/5-110    AC A0A4E0Q7B8.1
#=GS O30157_ARCFU/288-393      AC O30157.1
#=GS D7DRU4_METV3/6-106        AC D7DRU4.1
#=GS D5E7G1_METMS/22-127       AC D5E7G1.1
#=GS A0A166DS15_9EURY/32-107   AC A0A166DS15.1
#=GS N0BDL2_9EURY/3-110        AC N0BDL2.1
#=GS A0A133U4F4_9EURY/48-155   AC A0A133U4F4.1
#=GS O28745_ARCFU/150-255      AC O28745.1
#=GS L0KZY4_METHD/17-122       AC L0KZY4.1
#=GS O30116_ARCFU/150-254      AC O30116.1
#=GS O30116_ARCFU/2-110        AC O30116.1
#=GS G7WL80_METH6/4-106        AC G7WL80.1
#=GS A0A062V4D3_9EURY/4-109    AC A0A062V4D3.1
#=GS A0A1V6N1L9_9EURY/24-106   AC A0A1V6N1L9.1
#=GS O30117_ARCFU/5-113        AC O30117.1
#=GS O28745_ARCFU/287-391      AC O28745.1
#=GS A0A1D2W900_9EURY/6-110    AC A0A1D2W900.1
#=GS Q12WF9_METBU/5-110        AC Q12WF9.1
#=GS N0BIX7_9EURY/2-107        AC N0BIX7.1
#=GS A0A2V3JBL3_9EURY/3-111    AC A0A2V3JBL3.1
#=GS A0A2R6T5B4_9ARCH/12-111   AC A0A2R6T5B4.1
#=GS O30115_ARCFU/58-163       AC O30115.1
#=GS A0A1D3L4E0_9EURY/1-107    AC A0A1D3L4E0.1
#=GS F0T970_METLA/2-106        AC F0T970.1
#=GS O29593_ARCFU/3-111        AC O29593.1
#=GS A0A0F7IFV3_9EURY/9-109    AC A0A0F7IFV3.1
#=GS O30157_ARCFU/149-254      AC O30157.1
#=GS O30117_ARCFU/290-395      AC O30117.1
#=GS O29593_ARCFU/279-381      AC O29593.1
#=GS O30157_ARCFU/2-109        AC O30157.1
#=GS D3S2H3_FERPA/121-228      AC D3S2H3.1
#=GS O30059_ARCFU/172-276      AC O30059.1
#=GS Q6LYE4_METMP/5-104        AC Q6LYE4.1
#=GS O30059_ARCFU/39-144       AC O30059.1
#=GS O29593_ARCFU/148-252      AC O29593.1
#=GS A0A2V3JHY2_9EURY/5-110    AC A0A2V3JHY2.1
#=GS A6UT38_META3/6-105        AC A6UT38.1
#=GS A0A0F7IFV3_9EURY/289-392  AC A0A0F7IFV3.1
#=GS O30117_ARCFU/153-258      AC O30117.1
#=GS N0BA08_9EURY/3-111        AC N0BA08.1
#=GS N0BBU2_9EURY/146-249      AC N0BBU2.1
#=GS F6BCH0_METIK/2-106        AC F6BCH0.1
W9DV09_METTI/5-110                   ..............................v-IQVVSRDN...G.ELTSRKVKAAPYEFT..I.AT.R.AKWEMVISDEDMEIRAGEFKKVNVKEICLDPDMVALPCTFSHHAVVSLIKVGSKGGAKPVDSERIINSAYVIGQESG....
D3S2H3_FERPA/2-88                    .............................yr---------...-.----------TLAFK..S.AK.T.AYWKLLVAKESLDVKKGEVYRVEVEKIRLPPNTIVSPLAIKRHGYGIVVDVKE-DKPEKIDGERSIEAAYFLATSDG....
A0A133UP75_9EURY/2-107               ..............................s--KIVFWDD..kG.EIQRQDIETTVTSYD..L.GT.L.GIWESVISQEDKKVKNDKVEKITIKKIKLPPRAIVIPCIFKRHALGYVESVGSPGKAKKIEEDREIKEVYFRPVSDG....
E3GX44_METFV/2-107                   ................vklmtrfreivkefe---------...-.----KKVHADK-DFR..IdSH.Y.GLMRAIVANENIEVKSGDVKSLKIKKITIPKNHIIWICGYGVHPLGHIIAVGE-EVPLPITMERSADHATFVAAKSG....
A0A1F2P6H3_9EURY/2-110               ...............................KVDIVYWEDe.iGkSLNRVSVDVHPFGIQ..V.GM.R.AEWQMAVAAEDKEVKAQMMVPIDIKPVDIPAKAIVLPCFFMRHALGIVTSLASLGRPLRVEDERRISQVLFYPIQDG....
Y614_METJA/6-110                     ....................vfrilgrmtki---------...-.---EKEIKEEEAKYDliI.KN.E.AKIEPIVAEEDMEFKQGDIKPIRIKKIKIPPMSVLLICPYGRHRVGHVVAVGE-EVPMPIDVEREVDMAMFAC----gfeg
O27033_METTH/2-108                   ..........................mvril-----TRLG...QvREAEEKYRRELVDFR..M.GE.VyGNLRAIIADEDVEVRAGEAKPVKIKEVSIPANHIVFMCAYATNPLGHPIAAGE-ETPLPISMDRKADHATFVAAADG....
A0A328P9S0_9EURY/2-109               vriltrlgevrrateqyakelvdfrlidadi---------...-.---------------..-.--.Y.GHLRAILAAENVKVKAGEVKPIKIKRIRIPSNHIVYLCAYATHGLGHVIAAGE-EVPLPISMERSADHATFVAALSG....
D3S2H3_FERPA/262-368                 ...............................KARIVYWED...EwRVNSSEIEIEPLSFK..R.SP.L.GLIEPIFSAENKKLIKGVPEVVKIEMLEFPSGTILQPVSGKSRDQLMLIDVMSFEPPRLVEEDKRITHAVVLPTET-t...
Q8TUS8_METKA/2-106                   ......................vfvsvakrk---------...-.VTERVRRRREPYDFK..T.DM.FeGRFEPLIAAEDVTVEEGEDVIIKVEPIEIPPHTMVLLSPYARNPYGHVLAVAE-EFPKMMELGRKVEQVYFAAVRHG....
A0A366MEH9_9EURY/13-107              .........remehskagkmdleignipvls---------...-.---------------..-.--.-.---KIIVADEDMELKGGKSVSIKIKEIEIPANYIGSIGAYASNKYGHPIAVGS-DTHIPLNMDKKVNRAAFVIISDG....
D7E7T8_METEZ/5-110                   ..............................i-VQIVSRKN...G.ELKSTKVKASPYEFT..M.AT.R.AKWETIVADGDVDIRAGEYKKIPVKELYIEPDMVAMPCIFSQHAVASVLRIGTKGGCKPVEEERLVNTAYVIGQETG....
N0BBU2_9EURY/287-390                 ..................fldadriegdkek---------...-.----KMKYFPPVFYK..R.KN.T.GRWGIIVADERVYVKKGKPVIVKIRDFILPERSIITPMYLMKNDMGTLLGVIQ-PGIADIHSEKYITHAVFLPLIDG....
N0BBU2_9EURY/2-106                   ..............................e-VNIPILTK...D.GIFREAREFTPFGFK..M.SE.Y.VRWGFLVADERVKVSKNELFLIKIKPIKLPKNTMISSIGVVRHPVVTVLDVKGDHKDES-KGESEIREALVIASDDG....
O28745_ARCFU/2-110                   ..............................a-VKMKYWTDevgG.ERGSLKVELKPFGYR..I.IP.L.TQWKTLIAMDDVEVKKGEPEIIEVRPFTIPGGTMVGPLHIMRHALGTVLDVVECGIPTRVEDEKCIQRVVFLPVDDG....
D7E6H5_METEZ/5-110                   ..............................v-IQVVSRKN...G.ELNSTKVKASSYEFT..M.AT.R.AKWEMIIANEDMSIRSGEFKKIDVKDINVEPDMVAMPCIFSQHAVASVLKIGAKEGNVPVDKERVIDSAYVIGQETG....
U6EE75_9EURY/1-106                   ............................mvr---IISRLD...QvKKEQKKLAKPTPDFE..I.GN.IsGKVRAIIAAEEKEFKAGETKPVKIKKIDINANHICFISAYGTNKNGHTIAVGE-ETYLPISMERSADHALFAAA---ld..
A0A0F7IFV3_9EURY/149-254             .............................eg--NVVFREG...D.EIVREKVRVKETWYS..R.WN.L.GEWRMMVADEDVKLIPGDARLVKIRAIELPPNTIPVPLYGYRTPFGTVLDIYAPGRPRKIEEKKLVTHALLMPTEEG....
A0A4E0Q7B8_9EURY/5-110               ..............................l-IQVVSRDN...G.GLVSKKVKAAPYEFT..I.AT.R.AKWEMVISDEDIEIRAGEFKRVNVKEILLEPDMVAIPCTFTHHAIVSLIKVGAKGGAKPVDNERIVKYAYVLGQENG....
O30157_ARCFU/288-393                 ...............................EANHVYWKD...G.RIRRRSIVVTPFSFR..R.SS.I.GRFEPVIAEESVELAEGEVGVVKIRDLEFPSGTITQPLTSFNHAFGSIVDLCAFSPPKMVEEDRVVTHAVVLSPKGG....
D7DRU4_METV3/6-106                   ........................gkikkie---------...G.ELSDKNIKDANLHFE..L.--.T.GNKVLLLADEDITVKKGDIKEIKVEKIALEPRSVIVKSAYKLNKYGSVISVGE-EIPVPFESQRDIDRVIFLATIDG....
D5E7G1_METMS/22-127                  ..............................v-IQVVSRKK...G.EIVSKKVKAAPYEFT..I.AT.R.ARWEMVIADNDLEIRAGEYKKIPVREITLDPDTLAMPCAFTYHAVASVLKIASTEGACPVDKERTVRYAYVFGQTNG....
A0A166DS15_9EURY/32-107              ...........................ilsr---------...-.---------------..-.--.-.----LIVADENITLNEGTSTSIKIREIYIPEKHIVSIGAYAANKYGHPIAVGG-DTHLPLSMDKKVNRAAFTVFLDG....
N0BDL2_9EURY/3-110                   ...............................EVRIVYRDEk.tG.ELKAEIVDTEDYEFT..I.AT.R.GSWKMLIADEDVEFKAGEVKPVRIRRTPLPRESIVLRCPVTRHAFGYVASLGRRGEPQPIEEDRELNYVIFKALDNG....
A0A133U4F4_9EURY/48-155              ........................snivfyd--------DeagG.EIKREKIEPIKAPYD..L.GT.L.GIWESIISDERKKVKFDKLEKIQVKNVEIPPSSIVIPCSFKRHALGYVETVSSLGRTNRIEEGRQISEVFFRPIQDG....
O28745_ARCFU/150-255                 ...............................EANITWRDD...G.NIYREKISTKVFGYT..R.TH.V.GVWEPLVADEDVGVRAGDVLRVKIRNVELPPNTVVVPLSISRNPYGVVVDVVQLGKPRRVEEPKNIEQAVFLAVDDG....
L0KZY4_METHD/17-122                  ..............................i-VQVVCREN...G.DIKCKKISAATYEFT..I.AT.R.AKWEMVIATEDADIRAGEFKKLRVKDISIEPDTIAIPCTFTHHAFVSLIKVGTDGGAKPVDTERTITYAYVLGQESG....
O30116_ARCFU/150-254                 ...............................EANITWRDN...G.NVYREKIRTKVFGYT..R.SH.V.GVWELLVADETVRVKRGDVLRIRIKEVRLPPNTVVVPLSIMRNATEPCLMSCSLASRAELRTRRESSRRCFLQWR--t...
O30116_ARCFU/2-110                   ..............................k-AEMLYWVDrvgG.KVEKLEVELKPFGYK..M.AP.V.TQWKTLIADGDAEVERGKPTIIKVKTIEIPENTIVGPLNIMRHALGVVADVVECGIPGRVEEDKCVSQVLFVPIEDG....
G7WL80_METH6/4-106                   ...............ithrvkkiieeideqk---------...-.--------RVPFDFA..L.QG.T.CHIDYLIAEEDKKFRSGDAKPVKIKKVAIPRNTILLISPYGRHGIGQVISIGE-EIAMPVELDRSADHALFVAGVDG....
A0A062V4D3_9EURY/4-109               ..............................i-VNVVSRDT...G.KLDRKKVRASPYEFT..I.AT.R.AKWEMVIANEDITIGAGKLERIKVKEIKVQKDMLAMPCAFSHHALVSVIKVGAKEGPAPVEIDRVIDTAYILGQESG....
A0A1V6N1L9_9EURY/24-106              ....................lkmgdipilsr---------...-.---------------..-.--.-.----VIVANEDIVLENGKSVSIKIKEISIPAKHIVSISSYAANKYGHPIAVGS-ETHIPLSMDKTVNRAAFIASSDG....
O30117_ARCFU/5-113                   ...............................KVKMLYWVDevgG.RAESMEIELKPFGYR..T.AP.I.TQWEVLIAAEDVEVEKGKPVIVRVEPVFLPGNTLVGPLSIMRHALGTLVDVVECGVPGRVEDEKCISRVLFLPVEDG....
O28745_ARCFU/287-391                 ..............................d-FTLVYRKE...E.KIIRKKVHLPPFGYH..R.SP.V.ARWEVVVAAEDKELTKNKPVRVKIKKIKIPANTIVYPMEIMRHSDGVLIDLVS-DLPWRVEEGGKVDEAIFLPLFDG....
A0A1D2W900_9EURY/6-110               ...vlnrvdevkeelkgeelhalgnfkvgni---------...-.---------------..-.--.I.GKLRAVIADEDVDIKANEAKSIKIKKINIPKNYITFLSAYASNRYGHTVAVGE-EVHLPMSMKRTVDYASFLANIDG....
Q12WF9_METBU/5-110                   ..............................t-IQVVARKE...G.EMVSKKVKAAPYEFT..I.AT.R.AKWEMVISNEDLELRAGEYKKIAIKEVTLDADTLAIPCAFTYHAVASVLKVSSKEGNCLVESPRTISHAYVFGQETG....
N0BIX7_9EURY/2-107                   ...............................EVTISYRKD...S.EVVYEKANVEEAGYF..L.GP.V.AYFVNIVADEDVEVKANRVKVIKVQEFKISGNERLTLLDRYRHALGTLVAVVEDGKPERIDVPSRVKYVVFYPIADG....
A0A2V3JBL3_9EURY/3-111               ...............................KIELVCWKDrigG.EIKRETVEAFSYGFT..V.GP.H.GEWEMVIANEDKEVKKDKLVNIKIEQIEVPPRSIVLPCPIMRHALGIVTSFAAVGKPKRVEGRRLLDEAIFHPIFDG....
A0A2R6T5B4_9ARCH/12-111              .......nrksketkeikdgeegievdlsge---------...-.---------------..-.--.-.VKIRHLISKEDKSFKKGDSEPIKIKKNEIPKNHLLVISGYARQRNGHVIGVGE-NYPKPIEISRTVDDVLFAAGKDG....
O30115_ARCFU/58-163                  ...............................EVNIVYRTG...G.GIVRKKLSVDPFGYR..R.SA.N.ASWEVIIADERKEVRYGEPEIIKIKKIKIPKNTITYPMCIMRHAYGSFVDLYSDLPPRKVEEDRFVNYAVFLPIADG....
A0A1D3L4E0_9EURY/1-107               ............................mvr---IVTRLG...TiKKELKDMEGADVDFK..V.GSvV.GKLRAIIADEDVDFKASDVKPIKIKNIEIPANHICILYAYAENRYGHTIAVGE-ETPLPISMDRTADHATFVAALDG....
F0T970_METLA/2-106                   ..................riitrldavkkel---------...-.----AQAKAEKLDFQ..V.GS.IsGNLRAIIANEDMEFQSGNIKSIEIKEIPIPANYLSYLSGYGSNSYGHTLAVDE-EIPLPLSMERKADHAMFAAAKD-c...
O29593_ARCFU/3-111                   ..............................r-AKLLSWQEg.vGsKTFEFDVDVEPRSYV..I.SK.V.SQLSPIIASEDLTVCEGEVAVVGTRVIEIPENTVVRPVAAISHANGFVADVIECGAPGMVEDEKCINHAVFIPTRSG....
A0A0F7IFV3_9EURY/9-109               ......................rdidkkipe---------...-.---RGELSFKNAIFK..S.AG.Q.AYWKVLIADESVEVRKNTLEIIRVRKLHLPPKSTIAPLSIMRHALGTTLDIVP-SEIKKVEETREVTHVLFYSIDDG....
O30157_ARCFU/149-254                 ...............................EANLVYVKD...D.EVVREKRILKEYWYR..R.WH.I.GEWYPLIAREEAEVTKGEAVKVRIENLELPENTIPVPMSIMTHALGTVIDIAHMGRPRAVEERKLITHAVFLPALDG....
O30117_ARCFU/290-395                 ...............................KVRIVYRSG...D.GIVKREVEVEPFGYR..R.SP.V.GKWEALIADESKPVRYGEPVVVKVKRVRVPPKTILYPLHIMRHAYGTVADVFCDCKPWKVEEGGEIKKVVFLPVMDG....
O29593_ARCFU/279-381                 .......................qfsrkagk---------...-.GVVKTIHEYRSKPLR..V.GR.K.GEWRPAISDENRKLIRGVAEIIKIRPINVPDYAVVNPLGIMRQAYGTMVGGIA-NEPWSLESRKTIEEVVFLPIMDG....
O30157_ARCFU/2-109                   ...............................KVRTVYWKLd.gEwSTLEKFAEISSAYFK..T.GS.T.AYWKLLISTQEVQVKRGRPVIIKVRKVELPAKTAVSPLSIQRHALGTVVDVYG-ERLYRVEEQKNITHVVFLPVEDG....
D3S2H3_FERPA/121-228                 .......................nvrmekkk-VKLVTKKG...-.---RKEVEIEELWYR..R.WN.V.AEWFPIIADEDKSVEKGKLEEIRIKTIELPPNTIPVPLYIMRNAYGTVLDLEA-VELKKVEEKTRINKVYFLPVFPG....
O30059_ARCFU/172-276                 ......................kdevlakvv---------...D.ERGRKEFRIKPFAYR..R.KT.I.ARWEPIVAAENRKVRKGEVEEIAIEPISLEENTIVYPLYVMRNAFGSVVDVVE-ERPRRVEERREIIKAVFLPVFDG....
Q6LYE4_METMP/5-104                   ..........tgkikeiedkiegkkqegakl---------...-.---------------..-.EI.V.GQKVPVFAAETVEIKAGEIKPINISKICLPKKTVLMPSAYIQHKLGNMVSLGE-ETPVPFEHERCLEYAIFVAVKEG....
O30059_ARCFU/39-144                  ..............................q-ANLTWKED...G.EIRRERIKTRFFGYF..R.SH.V.AEWEPVIAAESVDVERGEVARIKIKEITLPEYTVITPLFIRRHALGSLIDVVQQGKRRKVEEKKRIGEAIFLPARSG....
O29593_ARCFU/148-252                 ..............................k-ASLTWVEG...G.VFYRENVTGTFSGYF..E.SE.R.CSLLPIVADERVRIEKGGVSAVEIERVDVKGGSIITPYGLAANAFAQLLDLVG-GRTRKFEEDRVFDEAVLVGFSDG....
A0A2V3JHY2_9EURY/5-110               ..............................t-IQIVSPAE...Q.GLERSKVEVSPYEFT..I.AT.R.AKWEIIVADEDMTIAKGAFEKIRIREITLQHDLLALLCAFSPHALVSVVRVGSGAGAAPVETDRCIKVAYILGQETG....
A6UT38_META3/6-105                   .......griekieealkekkypgkiiidvq---------...-.---------------..-.--.-.GKKEPIIASEAVEVKAGEIKKVAVNKIEIHPNNILFISAYAKHQLGHTLSVGE-EIPMPFDSKRIVEHAIFIAIKDG....
A0A0F7IFV3_9EURY/289-392             ..............................g--NVVLRSG...E.GIRRVEFEHRPFVFR..R.SS.V.GYLKPIIAAETKRVQTNKPEKIEIEKIDVPAGSIIQPMSGKGHAYGITIDVE-FERQGFVEEDRVIDSAVILSPFDG....
O30117_ARCFU/153-258                 ...............................EANIVWRDN...G.NIYREPAKVTILGYM..R.SH.I.GVWELLVADETVRVKRGDVLRIRIKEVRLPPNTVVVPLPVMRNAFGTVLDVVQLGKPSRVEEEKTLHQAIFLAVEDG....
N0BA08_9EURY/3-111                   ..............................s-VEIVYWDDrinG.SLKSDKINVEPYGFQ..L.SP.I.AEWRILISAEDKEVEESKVCAIDVEPIDVPENAIVSPLPIMRHALGVLLDVYVPGKLKKVEESKKITQAIFLPVMSG....
N0BBU2_9EURY/146-249                 ..............................e-FTIKTRTD...S.EIKSFQTIKSTHGYW..R.SN.Y.GYIEYLISNESKKIKQGEVVEVEIKQVEMPSNTIAVPNGLISNIDGCVIDLI--GSFRGIEEDRVLSKVLFIPVADG....
F6BCH0_METIK/2-106                   .................frilgrvgkiehdi---------...-.----EETKKYHYDFK..F.KE.G.GKIVPIVADETVEFKQGDAKSIKIKEIKIPPKHLVLICSYARHRVGHVIAMGE-EFPVPVEMERSADRAMFIAGIDG....
#=GC seq_cons                        .................................phh.h.t...t.th.ppchchpshtap..h.us.h.upachlIAsE-hcl+pG-schI+I+cIclPssollhPhsht+HuhGpllsVsp.ttst.lEp-RplscAhFlshpDG....
//