#=GF ID   DUF2299
#=GF AC   PF10061.16
#=GF DE   Uncharacterized conserved protein (DUF2299)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG5440)
#=GF GA   28.00 28.00;
#=GF TC   29.00 28.00;
#=GF NC   27.10 26.90;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0097
#=GF DR   INTERPRO; IPR018747;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Members of this family of hypothetical bacterial proteins have
#=GF CC   no known function.
#=GF SQ   91
#=GS A0A0F7IFG3_9EURY/3-141   AC A0A0F7IFG3.1
#=GS A0A3A5WAG2_9ARCH/6-154   AC A0A3A5WAG2.1
#=GS F4BTC5_METSG/1-101       AC F4BTC5.1
#=GS Q9YB98_AERPE/7-149       AC Q9YB98.1
#=GS D2RF01_ARCPA/1-139       AC D2RF01.1
#=GS A0A5B2Z7H6_9ARCH/6-158   AC A0A5B2Z7H6.1
#=GS A0A166CL16_9EURY/3-140   AC A0A166CL16.1
#=GS A0A1D2WDM9_9EURY/4-141   AC A0A1D2WDM9.1
#=GS A0A650CRP4_9CREN/1-50    AC A0A650CRP4.1
#=GS A0A031LMW2_9CREN/3-142   AC A0A031LMW2.1
#=GS A0A1G9XZ09_9EURY/5-146   AC A0A1G9XZ09.1
#=GS W7KU14_9CREN/2-130       AC W7KU14.1
#=GS A0A365T3L6_9EURY/6-148   AC A0A365T3L6.1
#=GS A0A087RXN8_9ARCH/6-145   AC A0A087RXN8.1
#=GS A0A484I9L1_9ARCH/9-148   AC A0A484I9L1.1
#=GS A0A0U2L7Z5_9EURY/3-141   AC A0A0U2L7Z5.1
#=GS G4RMZ7_THETK/3-141       AC G4RMZ7.1
#=GS A0A8J7XYS5_9EURY/5-143   AC A0A8J7XYS5.1
#=GS A0A2U9IC17_9CREN/3-142   AC A0A2U9IC17.1
#=GS G7WR14_METH6/9-149       AC G7WR14.1
#=GS Q4J730_SULAC/3-131       AC Q4J730.1
#=GS M0CKH4_9EURY/6-147       AC M0CKH4.1
#=GS A0A328PBB7_9EURY/2-139   AC A0A328PBB7.1
#=GS A0A650CP05_9CREN/2-141   AC A0A650CP05.1
#=GS W7KTP9_9CREN/1-140       AC W7KTP9.1
#=GS A0A366M9J3_9EURY/3-140   AC A0A366M9J3.1
#=GS A0A9W4UYY3_9ARCH/3-142   AC A0A9W4UYY3.1
#=GS Q4J8C4_SULAC/2-141       AC Q4J8C4.1
#=GS A0A166AAJ8_9EURY/3-140   AC A0A166AAJ8.1
#=GS A0A2U9IK55_9CREN/5-144   AC A0A2U9IK55.1
#=GS A2BJX4_HYPBU/8-150       AC A2BJX4.1
#=GS A0A1N6YKG4_9EURY/6-147   AC A0A1N6YKG4.1
#=GS A0A5B2Z356_9ARCH/11-151  AC A0A5B2Z356.1
#=GS Q96ZK0_SULTO/3-135       AC Q96ZK0.1
#=GS A0A166CYR4_9EURY/4-125   AC A0A166CYR4.1
#=GS A0A9E4ZQA2_9CREN/5-152   AC A0A9E4ZQA2.1
#=GS A0A8K0Y5H6_9ARCH/7-145   AC A0A8K0Y5H6.1
#=GS R9SMA0_9EURY/3-140       AC R9SMA0.1
#=GS I3TF05_THEC1/10-157      AC I3TF05.1
#=GS A0A087S875_9ARCH/47-192  AC A0A087S875.1
#=GS D9Q1N3_ACIS3/3-147       AC D9Q1N3.1
#=GS A0A126R296_METOL/4-141   AC A0A126R296.1
#=GS A0A2U1S5E4_9EURY/3-141   AC A0A2U1S5E4.1
#=GS A9A5H6_NITMS/6-145       AC A9A5H6.1
#=GS F8D3Z6_HALXS/6-147       AC F8D3Z6.1
#=GS A0A1V6N1W9_METAZ/3-140   AC A0A1V6N1W9.1
#=GS D3S3C1_FERPA/61-200      AC D3S3C1.1
#=GS A0A654LX17_9ARCH/1-152   AC A0A654LX17.1
#=GS A0A654LW86_9ARCH/11-151  AC A0A654LW86.1
#=GS A0A031LKJ6_9CREN/2-127   AC A0A031LKJ6.1
#=GS A0A7K4N062_9ARCH/4-142   AC A0A7K4N062.1
#=GS A0A151AJU2_9EURY/6-147   AC A0A151AJU2.1
#=GS A0A9D3B5J5_9ARCH/6-145   AC A0A9D3B5J5.1
#=GS H2C2Q6_9CREN/3-133       AC H2C2Q6.1
#=GS A0A087S8C2_9ARCH/1-140   AC A0A087S8C2.1
#=GS G0EGZ2_PYRF1/4-149       AC G0EGZ2.1
#=GS A0A5B9D7P6_9ARCH/14-152  AC A0A5B9D7P6.1
#=GS A0A8T8KGA6_9EURY/1-138   AC A0A8T8KGA6.1
#=GS Q970H7_SULTO/2-141       AC Q970H7.1
#=GS S2EJM8_9ARCH/1-140       AC S2EJM8.1
#=GS H2C7A9_9CREN/2-134       AC H2C7A9.1
#=GS O27461_METTH/2-139       AC O27461.1
#=GS A0A6A9QWH5_SULME/2-140   AC A0A6A9QWH5.1
#=GS A0A0V8RTB2_PYROC/5-147   AC A0A0V8RTB2.1
#=GS A0A654LX14_9ARCH/16-110  AC A0A654LX14.1
#=GS Q97U36_SACS2/6-145       AC Q97U36.1
#=GS A0A6A9QRM2_SULME/3-128   AC A0A6A9QRM2.1
#=GS A4YEZ2_METS5/3-133       AC A4YEZ2.1
#=GS A4YGG7_METS5/6-142       AC A4YGG7.1
#=GS A0A2U9IQ72_9CREN/3-133   AC A0A2U9IQ72.1
#=GS A0A6B0VHK3_9EURY/6-147   AC A0A6B0VHK3.1
#=GS A0A8J7ZPE8_9EURY/6-148   AC A0A8J7ZPE8.1
#=GS A0A8J8Q5S0_9EURY/6-147   AC A0A8J8Q5S0.1
#=GS A0A654LW22_9ARCH/14-144  AC A0A654LW22.1
#=GS E8R8T3_DESM0/5-152       AC E8R8T3.1
#=GS A4YGG8_METS5/1-140       AC A4YGG8.1
#=GS A0A9D2X2P6_9ARCH/5-62    AC A0A9D2X2P6.1
#=GS A0A484IDI0_9ARCH/11-151  AC A0A484IDI0.1
#=GS A0A8J8PR96_9CREN/1-86    AC A0A8J8PR96.1
#=GS A0A5B2YY71_9ARCH/9-148   AC A0A5B2YY71.1
#=GS F2KPK4_ARCVS/1-137       AC F2KPK4.1
#=GS A0A9Y1ZA72_9EURY/6-148   AC A0A9Y1ZA72.1
#=GS L0ABU2_CALLD/3-147       AC L0ABU2.1
#=GS A0A654LZM7_9ARCH/8-139   AC A0A654LZM7.1
#=GS A0A8D5U2P3_9CREN/3-144   AC A0A8D5U2P3.1
#=GS E3GWF4_METFV/3-140       AC E3GWF4.1
#=GS Q97V42_SACS2/6-136       AC Q97V42.1
#=GS A0A654LZH1_9ARCH/9-148   AC A0A654LZH1.1
#=GS H2C7B0_9CREN/7-146       AC H2C7B0.1
#=GS O30261_ARCFU/1-137       AC O30261.1
#=GS D5U0M1_THEAM/5-152       AC D5U0M1.1
A0A0F7IFG3_9EURY/3-141              ....................f-KEMVRNWL.MDEG..F.FKKE....VEDENADFHF.IIEVSP..GSGQVIDVIAPKGR-DLLLVASGIKLSDEHYAKVMGLSEKEREK...LMWEIRFD....LLFLATEFQIV-..PDAMNP...............QLFQFTR..KL.Y.PED...............LT...RQVLMDAISEVHKCKLYVVWKM.......
A0A3A5WAG2_9ARCH/6-154              ....................a-ERLVRSWL.ASER..I.EIRE....QEDPRAQLHL.LVKYPQ.gKNGHMFAVVIPKGR-DLLAISSMTRVDEGQQSSMRDMMKEDEDEwknWMHECRMQ....LIASGVDWGIHLghSGKNRPg............plQAFNVSE..PV.W.FDG...............LT...KNEMMQNLRRLWLAKLGIIH--di.....
F4BTC5_METSG/1-101                  .....................---------.----..-.----....----------.------..-----MSIIQPQGHEDMVVIFSRIMLADVHQKAIMHLLPQQKER...LMWQIRYD....LLFRQSSFEIE-..PAGEDM...............RSIRFTR..EI.Y.YDG...............LT...KDRLMEAIRENFKCELYVVWKF.......
Q9YB98_AERPE/7-149                  .....................LKNKILAWLaDEFN..V.SVKS...lPKNAPLDWAI.KAETQA..PVKVALVIQKPRGR-DVVAVTIGIALSQKHREALSKLGPGAREE...FAVSLVRD....LIALCPHCRVIA.qPNPRDL...............QTILISR..EL.Y.SDS...............LT...RQSLIDASVTLVNMFLVTVLKL.......
D2RF01_ARCPA/1-139                  .....................MKDVVKSWL.VEEG..I.LKAE....VPDENAEWHF.LVEFPP..NSKQMCDVIKLKHK-DIVLVVSGIVLSDDHYKALHSLPEEKKRA...LIHRWKID....LLFRNAEFRMI-..PDAENV...............KQIEFQV..PL.Y.LEE...............LT...KSELMKALREVFKCKLYIIWS-v......
A0A5B2Z7H6_9ARCH/6-158              ...................il--NKIYKWT.ELAG..L.KLDQdeslGESFGIDFIG.SVKSND..-FGYNIAIFKS---EELIKLSTYYRFNENTFNVISKFKDK-GFE...FLSDIQLA....LLQMNLNYAFLD..--KNNPsdtqvdikdieienlESIEISK..TI.Y.FDG...............FN...KNLYYDTIESIVHAAQVITLLF.......
A0A166CL16_9EURY/3-140              ....................d-EKQIRDWL.VEEG..F.YKDV....IHDENANFHF.IINYPE..--DHVIDLIQPKNKKDVLLVGCATEISPEELGIIKDASIKKKEK...FIWDIRFS....LNQFLLDFELE-..HPDNNL...............QRFIITE..EI.Y.EDG...............LS...KNNLIFALKKVFKGKLQCIWLI.......
A0A1D2WDM9_9EURY/4-141              .....................IESKVQKWL.SDEG..L.FRQK....VPDDNTNFHF.MINYPE..--GHVLDIIQPKGKDDMILIACATNVSPEHQTEIKKLSSKKRED...FIWDIRFL....LNSQFVDFQLQ-..HPDNIL...............QNFVITE..EI.F.EDG...............LN...KDRLISTVKKIFRAKLQGIWKI.......
A0A650CRP4_9CREN/1-50               ....................m---------.----..-.----....----------.------..--------------------------------------------...--------....------EFFFNP..TCAEIP...............KSVQIAK..IV.F.MEG...............LT...KNEMLNVVELVKNSAYLTLSWF.......
A0A031LMW2_9CREN/3-142              ....................s-DSNVERWL.RDLG..L.NVSR....PPQAKEHFHV.LVTPPQ..-GGPAFEVIRPTENQKFYLVVMGIAIYQGHQDALKAMREDERKK...FLNDLKYD....LLKMGTDVILMP..MGDQIP...............QVIQIVR..VL.L.IED...............IT...PNDLVNCIYLVKNAGMLVISKF.......
A0A1G9XZ09_9EURY/5-146              ....................s-EEKIESWL.DEQR..I.SDWTv..vREEGGEQFSF.EVELHH..---IPVDLTVLVGPNS-LNIIGGFTFDPELLANL-----LDRKE...LWHQFRTEamivLTNVRGFYAFL-..DEDFNPtsf.........eemRRISLQY..FI.Y.PDG...............AS...QHLFMNSLYDMARAEAFLMW--r......
W7KU14_9CREN/2-130                  ....................n-ENDIANLF.TELG..M.KVEK....GNAPGVYTQL.IISPPL..GDGPKVTVIRPSSTSNYFVVTMVIETDEGRLT----------PS...KVRAITTE....LAKMNVEVYMTP..P--DKP...............RLIHIAK..II.Y.AEG...............AN...KNDAINAVTLVKNAGIVAF---nll....
A0A365T3L6_9EURY/6-148              ...................da--EQIQQWIdDELV..E.NIEQ....VPDNAAEFNF.AIEMSN..---ILVHVVQRQSD-GPVIIGQQIEYSEDIRSRIQNLSEADRND...LVARIREL....LTEVPVIYGFHN.qNGENVIfk...........dmSQIFLEY..RI.Y.PDG...............LS...QHSLMTGLVDVWKAMRYLDD--iv.....
A0A087RXN8_9ARCH/6-145              .....................MRDNVERWL.IHEG..L.KFED....IKNQENTFQI.LVKHAG..PAGVPVEIFEPKAQQGILVIGSKVNMKNNQIARYLGFSEAEKEK...FEKKVADY....CYTIQAINKNTT..--EDGK...............RKIGVYV..VL.D.KEE..............dIN...QQGLFDAMDRVSEMHEKTARFL.......
A0A484I9L1_9ARCH/9-148              ..................vyg---TLLQWL.RDYD..Y.TVKEd..eSKKDALKYYT.KVFPPN..EKVKFFEIVSDESYKDGFLLRMSVAFTPQDRNDFERLKQEAQND...LFIRIHKI....LSPIRLLCKIEN..------...............SVISVEK..FL.F.IDVn............svMC...KQYFWDSVIEMSNAMYLIELTF.......
A0A0U2L7Z5_9EURY/3-141              ....................e-EETIKNWI.VDEG..I.FREK....KFDDNADFHY.IIEFPK..--DNIMDVVKPKGK-DFILIACATQVSPQHLDLMNNSTPKQRSD...FLLDVNMG....INQFLVDCQLAI.dQNTNLL...............QQYVITY..QI.F.EDG...............IS...KNNLFDALKRVFKSKIQCVWII.......
G4RMZ7_THETK/3-141                  ....................l-DGEIERWL.KGLG..L.KIVV....PPNAPEPFHI.STSPPT..-GVPIVDVVRPKDA-EYYVIAMGIAIHPDHKRALSSMKEQDRRR...FLLELKRA....VLAMGVDFAFIP..PDAEVP...............DFVQISK..PV.P.TAG...............LD...ARSFLEEYYRVRNAGLIVMVS-f......
A0A8J7XYS5_9EURY/5-143              .....................LEKRVEELC.LEEG..I.VIQK....VRTEMAEFQL.NLQFPS..-PQSSLNVFQPKGKEDTIIVGAVIEVSDTHKQGLRALDIKKREE...FIWNLRLM....LAQGRVEFEMR-..HPDNIL...............ERVRVHT..FL.F.QDG...............FS...KQAFMNALLDVNRSKLQVIWFI.......
A0A2U9IC17_9CREN/3-142              .....................LDNEIKNWI.QSLG..L.SIFT....PPQAKEFFHI.SVTPPQ..-GGPVVDIVRPLENSNFYIIAMGVGVHPTHQNALKELKDSDRKK...FINEIKYD....ILKMGLDVIFLP..MGQEVP...............QIIQITR..VV.I.AEN...............LT...ANEFMNSFYFVRNAGMLVIFKF.......
G7WR14_METH6/9-149                  ....................a-RTLIHNWM.ADRG..Y.FIKE....GDFIGYRFEF.IGKFGN..--DTHFSIIQPESLPRAVVVVSNVSVSAAHYDALSSMELKDREE...FIWDLKRE....FIFLPSSFTFDPsfEQLGIP...............KSIQFSK..EI.S.YDE...............LT...EGRLHEAVDYNSRCVLWVIWVF.......
Q4J730_SULAC/3-131                  ....................s-DSEIVEIF.KELG..M.KVKE....EKQQGLHFHV.SISPPT..ANSAIVSIIRPTAFSKYYVVTMAIEVDPPKLN----------KK...VLREIGVE....LARLNVEFYVMP..P--DKP...............TTIQIAK..LL.Y.QED...............LS...KNELINTVTLVKNAGFIVFNI-l......
M0CKH4_9EURY/6-147                  ....................s-ETQVRHWL.DETA..I.RGVT...aHSDEDTAFNL.QVELSR..---LPVHVIKEEEF-GPVRIVGRSGFDTERTKELLR-DDQHRSE...LLQYVGPM....LAATPGFYTFLD..PGGAACql..........reaETVQVEY..RV.Y.PDE...............AS...QQALMDGIMSIATSMRYV----rnvv...
A0A328PBB7_9EURY/2-139              .....................LESKIKRWL.TEEG..L.LGQI....VDDENANFHF.IVNYPE..--DHVIDVIQPKDKEDLVLVACATSVSPEHLSKIRELSESKREE...FLWQVRFS....LNKFLVDFQLE-..HPRNIL...............ESYLVTD..EI.Y.NDA...............LT...KDRLISTIKKVFKAKLHVLWLI.......
A0A650CP05_9CREN/2-141              ....................n-DKELEALI.KELG..L.SITI....PPQAKEAYHI.VTAPPQ..-GFPSIDIIRPNDSSKFYLISMGILIHPNHKAAINEMKKEDKKK...FFQELTED....LLKMGVDFAFLP..PGTETP...............EVIQVLR..LV.F.MDS...............LT...PNEFLNVYYTVRNAGMLVIAK-i......
W7KTP9_9CREN/1-140                  .....................MDNKIREWL.QSLG..Y.SVRD....QPQAKEPFNV.VVSPPQ..-GGPVLNVIRPTQDGKFYIITMGIGIHPMHQNALRDMKEKERRE...FLSELKYD....LLKMGVDFAFLP..VNQETP...............QIVQVSR..LV.L.SES...............LT...PNEFMNSFFAVRNAGLLVIFK-i......
A0A366M9J3_9EURY/3-140              ....................e-EKKIREWV.VAEG..F.FKEQ....VPDDTANFHF.LVNYPD..--DHVLDLIQPKHKDDMILIGCASEIAPEQSALIKNAPDKKKEK...FIWDIRFA....LNQFLLDFELE-..HPENVL...............QRFVISE..EM.Y.EDG...............LT...KHSLIMTIKKVFKGKLQCIWL-t......
A0A9W4UYY3_9ARCH/3-142              .....................LRDDVERWT.SHAG..M.RMSP....VEDPDSTFHV.MARLPG..SGTPPVDVFEPAGQPGVMVVGTAVVLKSGQTGRYLRYNRAEKES...FEGRITDF....CNSIRAVSRILT..----EE...............GRVKVGV..YV.V.IDGg............gpIR...QGDFERAVEEVQGMHEKTTRF-m......
Q4J8C4_SULAC/2-141                  ....................n-DKEIEDVM.KELG..L.NVSR....PPQAQEKFHI.VTTPPQ..-GFPVVDIIRLTDKSRFYLITMGVAIHPVHKKAIGGLKLEERKE...FLNNLAED....LLKMGVDFAFLP..PGTDVP...............DAIQIIR..II.F.ADG...............MT...PNELLSAYYVVRNAGMLVIN--ri.....
A0A166AAJ8_9EURY/3-140              ....................n-EKQIQDWL.VEEG..I.YKEK....IHDEHANFHF.IVNYPE..--DNVIDLVQVKSKEDSIILGCGTMVSPEHQELIKNSPKSKQDK...LIWEFKST....INKFLVDFQLE-..HPNNIM...............QLFVITD..QI.F.FDG...............LN...KNALIFNIKKIFKVKIQCMLLL.......
A0A2U9IK55_9CREN/5-144              .....................LDNKITEWI.RQLG..L.NITN....PPQAKEPFHI.LVMPPQ..NAGPTLEIVRPPNQ-NIYLIVMGIGIHQLHQNGLRNMKKEDRTK...FLAELNYD....LLKMGVDFALMP..LGSEIP...............QAIQISR..TL.L.IED...............LR...PNDFINAIYAVRNAGLYVILKF.......
A2BJX4_HYPBU/8-150                  .....................LKDRIAGWL.AGAG..F.IVVSf.qgPLPSNAEWGL.LVSTPP..PLQVKLRVMGLRGG--AVTLGIGVNISEHHRKLIEGLSIEERVR...LTASMLEK....LLMLCPYCRVAL.qGSLGSP...............VGIIAEI..YI.D.GAE...............AT...KQRIVDDAARLVNIFLLINSIL.......
A0A1N6YKG4_9EURY/6-147              ....................s-SEQVEEWLdEDVV..Q.DVQR....VSDDETEFNF.QLRLAR..---LPLHIIKEETW-GPLRLVSKNAFDTDRTMELKQ-DDRSRQE...LLARIGPV....LAATPGFYTFLD.eEGI--Scdf.........aeaHSIQLEH..RI.Y.PDG...............AS...QQATMEGLMNLATAVRY-----lqnti..
A0A5B2Z356_9ARCH/11-151             ....................q-YENITNWLkNDPA..C.NIDE....TLDDDNIVTIiNCSYFE..--DFKIGVYVYKNDAGRVEIISSPRLLTRDGEILQNADDKIVND...FQTELTKD....LLKVGVFCSLQT..NKAGNS...............IGLTIIH..PL.F.FDT...............LT...RELFMNAVHAVARACLIAAI--ef.....
Q96ZK0_SULTO/3-135                  ....................t-DTEIYNWF.LELG..M.KVEK....VTSGNAYFHI.TVSPPV..ENSVKVSIIRTNPNSTFYIITVIIDLDVDKLK--------KNPS...LLKSIKLD....LIRMNLEFFLIP..PDAEIP...............KSIQIGK..IM.F.SEG...............LT...KNQILDTVTLVKNGAYLVLTTL.......
A0A166CYR4_9EURY/4-125              ....................g--KQIRDWL.TNED..L.FREE....IHDNNSIFHY.IVEYPE..--GNSIDIIQPKDKDDLIIIGCATNISPEHTNFLQSSSIEINRK...LIWDFKFT....INQMLLDFQID-..HPNNVI...............KTFIISD..EL.Y.EEE...............VN...RHKLV-----------------fk.....
A0A9E4ZQA2_9CREN/5-152              ....................a-SDMISRWL.IEET..F.TLRRl.eaPPEARIKWGI.NVSTPG..SPGVSFTIVNPADREDRYVLTLAILVSPEHLKELEKLKPADRLK...IMHSILSR....ALAVCIDCKIMV.qPNVLNP...............QAIVVNM..DI.F.EDE...............VTsygKGFFLRTVWRLINTYLSIVSGF.......
A0A8K0Y5H6_9ARCH/7-145              .....................LKDKIKKWL.EGED..F.AVSE....RAEETSDFHL.VISNLH..GKGTFADIVKLKNK-DFVILGSALQNPPEFLQLLSTMPERERSD...FFSHIQRE....LLKFKVDHEFH-..PNKLMP...............ERMIVRD..VV.Y.EED...............IT...RTVFMKCLKRVKFASLFLLWS-i......
R9SMA0_9EURY/3-140                  ....................d-ESKIIKWL.TDEG..L.LNKK....IQDQNANFHY.IINYPQ..--DHMMDLIQPVGKEDMILIGCATEIAEEQKNMISQSSKQIKEN...FIWAMRFT....LNQFLVDFELE-..HPDNEL...............NRFLITD..EI.F.EDG...............LT...KNELIHTIKRIYKSKLQCLWLI.......
I3TF05_THEC1/10-157                 ....................v-EERVNEWL.IQEG..F.IVRKl.eaPPEARITWGL.DVNTPP..PFQVNFKVFKTLDKPDRLVVLIGVVVSPEHRKYLTSMRQEEVLR...FMSRLTRI....LLTACVDCQLTI.qPSILDP...............QTLTVAL..VL.F.DDE...............VRaqgKQVFLKTVMRVLNAYSIIVSLF.......
A0A087S875_9ARCH/47-192             .....................IKNRIKKWL.SEEN..I.SFNE....VKEPKNVFHF.ALEDIG..PLKMRIEVFQDKNNLD-VITGFMTFLSKELTFNLYRFTEEQKED...FKRKVDDF....LSTLRVDYRT--..------...............-GIRVGY..EI.I.SERghygakyfirakqydLD...KEKFLRILDMTKETGLRSDEF-l......
D9Q1N3_ACIS3/3-147                  .....................LKDDVARWL.KDEE..I.DVDEv.pvPAGAPVEWAL.NATVKA..PLRVLLGVQKPKTKADRLVISMVVKVADQHKAALSSMAPKERAK...LMSQLLVN....VTSLCPSCIIVF.qPQLDLP...............DTIVVSK..VI.Y.DEN...............IG...PSAIGESVRVLVNEYALIVSFF.......
A0A126R296_METOL/4-141              ....................d-EEKIRTWL.MEED..I.IREK....IYDENANFHY.IINFPN..--DNAMDIIQPKTKEDVLLIGCATEVSKEEQNIIKNSSKSTNQE...FIWKIRFT....LNEMLLDFKLE-..HPNDEL...............KSFIITE..DI.F.EDG...............LT...KHLLIKSIKKVFKGKLECIWIL.......
A0A2U1S5E4_9EURY/3-141              .....................MEQNIQNWL.IEEG..L.LKEK....ANDPNANFHY.VINYPD..--KNNMDVVQPKGKNDLIIIGCGTQVSSEHIQLMNESSKSEKEE...FLWELRFG....LNNLLLDFQINV..DTNNNL...............NQFIITD..NI.F.EDG...............LT...KNSLIKTINKIFKAKLLCIWLI.......
A9A5H6_NITMS/6-145                  .....................MRDNVERWL.IHEG..L.KFED....IKNPENTFQI.LVKHAG..PAGVPVEIFEPKAQQGVLVIGSKVNMKNNQIARYLGFSEDEKAK...FEKKVADY....CYTIQAINKNT-..-TEDGK...............RKIGVYV..VL.D.KEG..............nIN...QQELFDAMDRVSEMHEKTARFL.......
F8D3Z6_HALXS/6-147                  ....................s-ERQVRWWLdRNAV..Q.EITA....HTQEETEFNL.QVTLSS..---LPIHLIKEEPK-GPVRVVGRSGLDSERARRLVR-DDGQRAE...LLSQIGPV....LATTPGFYTFLD.eES---Rgce........lreaETLQMEH..RI.Y.PDG...............AS...QQALMDSVMAIATGMRY-----lqnll..
A0A1V6N1W9_METAZ/3-140              ...................de--KIIKKWL.VEEG..L.FKEQ....IPDETSNFHF.LINYPN..--EHVLDLIQPKHKEDMILIGCASEIAPEQVALIKDSSNKKREK...FIWDIRFA....LNQFLLDFELE-..HPDNVL...............NRFVISE..EI.Y.EDG...............LT...KNSLILSIKKVFKGKLQCIWI-t......
D3S3C1_FERPA/61-200                 ...................iv--RRVRDWL.VEEG..I.YKDR....VTDENADHHF.IAEVPP..SSGQLIDIIFPKSREDLVAIVSGVKLSDEHHARLMSLKAEKRDE...ILWKMRFD....LLFLPTGFQIL-..PSAENP...............QIFQFVR..EL.Y.FDG...............LN...KNLFIEAVNQVYRCKLFVIWTM.......
A0A654LX17_9ARCH/1-152              ....................m--DNIYKWV.DLSK..L.RVEAdhdlIKSQKIDFIG.KVTVND..RYGYNIIIL---NESEIVKISTSYRFNQQLKGQISNL-RNIGFE...FLRSVQLS....LLQMNLQYVFI-..HKNHNPvsldkka.lnniddlESIDISK..NL.Y.FDG...............FN...QNFFFEAVTNVINAIEVID---il.....
A0A654LW86_9ARCH/11-151             ....................q-YENIIDWLkKDPV..C.NVDE....TIDDDNTVSIvNTSYFE..--DFKIGVYVYKNDVGRVEIISRPRLLTQDGKTLHNADDKIVND...FQTQLTKD....LLKVGVFCSLQT..N--KEG...............NSIGLTLifPL.F.FDN...............LT...RELFMHAVHVVARACLIAAI--ef.....
A0A031LKJ6_9CREN/2-127              ....................n-DEDVISLF.KELG..M.KVEK....V-NGPMFFQV.NISSLA..-GGPVVSVIRTSQNANYYIITTILDLPPID------------DK...TMKQIGLE....LSKMNIEFFLT-..QENENP...............RGLQLAK..LR.Y.AEG...............LS...KDQMLDSVTLVKNASYMVVNLL.......
A0A7K4N062_9ARCH/4-142              ....................l-HDSVERWL.VQED..Y.SIIE....T-KTEDNFKI.IIKNID..AFSNNLEIFEPKQQANVLVIGVKIPLKSKQMIRYRQLNQKEQEN...FEKKITDF....CYSIQVVNKFF-..-DEDGM...............KKVGVYI..VL.DkKEQ...............LN...QPNFMITLTKIIEISEKTAQFL.......
A0A151AJU2_9EURY/6-147              ...................ta--EQVEKWL.DDRV..VqDVER....TTENAATFSI.QCRLSH..---IPLNVIKEDTW-GPLRIVGRAAFDTERTAAVI-ADPDQRYE...LLARIGPV....FAATPGFYTFLD..EEETSTef..........pnvDSIQFEH..RI.Y.PDG...............AS...QQELMSGLMAIATAIKYI----qntv...
A0A9D3B5J5_9ARCH/6-145              .....................IRNNVERWL.IHES..Y.SFND....TKSDDDIFKM.TIKHVG..GFGNPVEIFEPKSQPNVLVIGAKVALKNNQNARFLKLNDDEKKN...FEKKVEDY....CYSLQAVHRFID..--EDGK...............KKVGVYV..VL.D.KEE..............qFN...QNSFFEALQRVVEMSEKMTQFL.......
H2C2Q6_9CREN/3-133                  ....................t-DTDLYSWF.KELN..M.KVEK....VASGNLYFHL.AISPPM..-GGLPVSVIRTTPDSTYYIVAVVMELDTAKIQ--------DRPD...VLKEMRKE....LLRMNVEFFFT-..PNETSP...............KSVQVAR..IM.F.AEG...............LT...KNEALNHVTAVKNAALMILELL.......
A0A087S8C2_9ARCH/1-140              .....................MRDNVERWL.IHEG..L.KFED....IKNQENTFQI.LVKHAG..PAGVPVEIFEPKAQQGILVIGSKVNMKNNQIARYLGFSEAEKEK...FEKKVADY....CYTIQAINKNTT..--EDGK...............RKIGVYV..VL.D.KEE..............dIN...QQGLFDAMDRVSEMHEKTARFL.......
G0EGZ2_PYRF1/4-149                  ...................li--EQVESVA.RKAG..L.RVEEprgvAPPPGMEWVRdIIAEGP..GIRVVVRVAGSERD-RRLVLIMPIGFSEVHMRLIQGLPLEERMA...LLARLLRE....VIHVCPYCRVGV.gGAPTTP...............QGIIAEI..H-.Y.VDG...............VP..dSQRLLDDITRLISVFMAVNTVL.......
A0A5B9D7P6_9ARCH/14-152             .....................LEEKIREYA.IDEG..I.LGKK...yPDNPKLEFSY.NINFPPnnPKPMKLMILKPKDR-KAIIIQSNIQIRKEHVDAINKKDSLGIKK...FFMIFQKY....MLTKNMLYNIDV..----KK...............YRYSVIE..SI.Y.PDG...............LT...EQFFYTTVRAVFNTSVFMNMTL.......
A0A8T8KGA6_9EURY/1-138              .....................MENTILKWL.ADEG..F.FKKK....IPDENSNFHF.IVNYPE..--GHVIDVIQPKGKDDMVVIGCATNVSPEHTSQIQNLNNKEKEK...FIWDFRFS....LNNFLVDFQLQ-..HPDNVL...............QSYVISD..QI.Y.EDG...............LT...KDRLILVIKKVFRAKLQGLWKI.......
Q970H7_SULTO/2-141                  ....................n-DEEIEKIM.KDLG..L.MIRK....PPEAKEYFHI.ATSPPQ..-GFPVVDIIRINKDSPFYLVTMGILIHPNHKSAIGNMKEEERRE...FLGNLVED....LLKMSVDIAILP..PNSEVP...............EIIQVSK..IV.Y.SEG...............LT...ANEFLDAYYTVRNAGIFVIN--ri.....
S2EJM8_9ARCH/1-140                  .....................MRDNIERWL.IHEG..L.SFQE....MKNPENTFQI.LVKHAG..KYGIPTEIFEPKSQPGVIVIGAKVILKDNQIARYLGFTEDEKEK...FERRVAEY....CNSIQAINRIVT..EDG--K...............QKVGVFV..VLdD.KEN...............IN...QQTVLDAINKASELHEKTS---rfl....
H2C7A9_9CREN/2-134                  ...................si--------F.KALG..L.NVTE....A-KSSEYLHL.TVSPPQ..-GGPTLDVVKPERDSKFYVLGMAISVHQFHQQQLRFLKEEDRRR...FLSKLRYA....LLKMGVDMAFTP..PNEEIP...............QVIFVSR..VV.Y.EEE...............ST...PNDLLHAMYKVRNAGTIAIFMF.......
O27461_METTH/2-139                  ....................s-QEMIKKWL.DEEG..F.LRME....VPDENARFHY.VVNYPE..--DHVIDIIQPAGKDDMILIACATSVSPEHQAGIRALSMEKRTE...FIWKVRFT....LNRFGVDFQLD-..HPENVL...............NSYLVTD..EI.F.FDG...............LS...KDRLISSIKNVFRAKLQVMWMI.......
A0A6A9QWH5_SULME/2-140              ....................d-DEKVEELF.KSLN..M.KTFR....PSQVQEFFHI.SVSPPQ..-GGPVVDIVKLKKESNFYIIIMGIQIAQEHYQKLSSMKPEEVAD...FLLEIQKN....ILLQGIEIAFLP..IGQEIP...............QIIQLSK..A-.V.FDV...............AN...ENEFLDSFTKVRNSGIYTMLSF.......
A0A0V8RTB2_PYROC/5-147              ....................a-REKITAWL.TDAG..L.VVAPl.naPMPSNAEWGL.LVATPP..PLQVKLRVIGLKNGD--VILSIGVNFSEQHREEVRKMPVEERVR...FTAQLLER....LIAVCPYCRVAL.nGSIDSP...............EAIVAEV..LL.S.GDE...............VS...RQRIMDGVARLVNLFLMVNAV-l......
A0A654LX14_9ARCH/16-110             gleksvdritiqntlplppdi---------.----..-.----....----------.------..-------------------------------KIIYELSP-NKSK...FLNELKVH....LMQMEVSTEIY-..PSFEKL...............ESINLAN..FI.Y.FDG...............FS...RNKLIHEIHKLADAT-------dlvfimw
Q97U36_SACS2/6-145                  ....................v-DKQIEDWL.RELG..L.VASR....PPQAKEFFHV.VATPPQ..-GGPTISVVRVNDSSKFYIIAMGIGIHPTHVSALMALNREERIK...FIIDLQLE....ALRYGVDFVALP..PNQEIP...............NVIQVSK..PI.F.IDG...............LT...ANEFINTLLNVRNAGVSIMLKF.......
A0A6A9QRM2_SULME/3-128              .....................LDQEITEWV.KELG..M.KVEK....-LEGNNFFQI.KVTPPL..-GGPSVAILRPKMEDTYYIFTIVVDIDVETQ-----------LK...VLRQIMLD....LMRMNVEFFLTP..--QGKP...............DKLHLAR..LV.F.ADG...............LT...KNQMLENLTLVKNAAYLAITWL.......
A4YEZ2_METS5/3-133                  .....................MDTEIFSWF.KELG..M.KVDK....VTSGGVYFHF.TVSPPM..-GGLPVSVIRTAPESTYYIVAVILDLDQSKFK--------ERPD...LVSQIKRE....LLRLNVEFFFT-..PDEKAP...............RSVQIAR..IL.F.AEG...............LT...KNEALSTVTLIKNSALLILE--lq.....
A4YGG7_METS5/6-142                  ..................dpv------KVF.KSLG..L.NVRE....VPQAKEFLHL.AISPQQ..-GGPQLELVKPEKDSKVYVLGMAVGIHQYHQSQLKSLPPNERKE...FLTSMRYR....LLRMKIDVGFTP..PDDEVP...............QLVFVSR..VM.L.DED...............LT...ENDVMNVMYKVRNAGTLVIFMF.......
A0A2U9IQ72_9CREN/3-133              ....................t-DNELFNWF.KELG..M.KVEQ....AKGGDLYFHF.TVAPPM..-GGIPVSIIRPKPDSTYYIVAVILDLDQERLK--------KNPI...LVEQIKKE....LLRMNVEFFFT-..PNDKEP...............KSVQVAR..LM.F.TDG...............LT...KNEALNNVTLVKNAALLILQLL.......
A0A6B0VHK3_9EURY/6-147              ....................s-ETQVRHWL.DETA..V.RSVT...aHSDEDTEFNL.QVELSQ..---LPVHVIKEEEF-GPVRIVGRSGFDTERTKELLR-DDQNRGE...LLEYIGPM....LAATPGFYTFLD..PNGDSCrl..........qraETVQVEY..RL.Y.PDE...............AR...QQALMDGIMSIATSMRYV----rnvv...
A0A8J7ZPE8_9EURY/6-148              ....................d-KQTVRNWIdDDLV..Q.RIED....VTDGDEAYNY.LVQVSG..---MNFHIGRVRGT-GPISVASTIEFDPETVALLMER-EEKRRD...LLTRFERV....LTIAPGWYTFL-..DGAGNPgcn........ftemRSIRLEY..RI.Y.PDG...............AS...QHALMNGLIDMANALVF-----lrdvm..
A0A8J8Q5S0_9EURY/6-147              ....................s-ETQVREWL.DDTA..I.GAVT...rHSDEETAFNF.QVELSQ..---LPVHVIKETEF-GPIRIVGRNGFDTDAARTLLR-DDQRRSE...LLQYVGPM....LAATPGFYTFLD.eEGT--Scel.........rdaETIQVEY..RV.Y.PDG...............AS...QQALMDGIMSIATSMRYVQ---nvi....
A0A654LW22_9ARCH/14-144             ....................i---------.-DVS..I.SVDE....TIDDDNTVSIvNTSYFE..--DFKIGVYVYKNDVGRVEIISRPRLLTQDGKTLHNADDKIVND...FRTQLTKD....LLKVGVFCSLQT..NKEGNS...............IGLTLIY..PL.F.FDN...............LT...RELFMHAVHVVARACLIAAI--ef.....
E8R8T3_DESM0/5-152                  ...................ig--DLISKWL.MDES..F.ILRRf.eaPPEARVKWGV.NVSTPG..TPGVNFTVVNPLDKPDRYILALAILISPEHARELDKLKPAERLR...VMHSILSK....ALTVCADCKIMV.qPNILSP...............QAIAVNM..EL.F.EEE...............IHrygKPFFLRLVWRLLNTYLAIVSGF.......
A4YGG8_METS5/1-140                  .....................MENKIKEWL.TSLG..M.KVWT....PDGAKEYFHV.SASPPQ..-GAPVVDVVRPTNMTPFYIVGMGIAVHQAHQDTLRKMSTSSRKA...FIDEIKYY....LMEMEVDVAFLP..PGQEIP...............QLINVSK..VV.Y.QDG...............LR...ANDFLDTFYSVRNAGTYVIMRF.......
A0A9D2X2P6_9ARCH/5-62               .....................LRDNVERWL.THEN..Y.KFKN....ATTDEDSFRV.SVKHIG..SFGNTLEIFEPKNQPNVLVIGA----------------------...--------....------------..------...............-------..--.-.---...............--...----------------------kc.....
A0A484IDI0_9ARCH/11-151             ....................p-YNSILDWLkKDPV..C.NIEE....TIDNDNTVSIiNTSYFE..--DFKIGVYVYKNDVGRVEIISSPRLLAQDGKILQNVDYKIINE...FQTRLTKD....LLKIGVFCSLQT..NKDGNS...............IGLTIIY..PL.F.FDS...............LT...RELFMSAVHTVARACLITAIE-f......
A0A8J8PR96_9CREN/1-86               .....................---------.----..-.----....----------.------..---------RPNANSKYYIVTMLIELDISRVT------SEKI--...--KRVLIE....LAKMNVEAFMNP..P--DKP...............NLIQIAK..LL.Y.SEG...............LT...KNEVINAVTLVKNAGFLAY---nli....
A0A5B2YY71_9ARCH/9-148              ..................vyr---TMLQWL.KDYN..Y.SINEe..sKIENGPQYYA.KVFPPN..EAIKFFEIVSEEEYRDGFLLRMRVAFTPKDRTDFEHLKEEVQNS...LFIRMHKI....LSPIRLLCKIEN..------...............AVISVEK..YL.F.IDVg.............sIT..cKQYFWDSVIEMSNAMYLIELTF.......
F2KPK4_ARCVS/1-137                  ....................m---DVKNWL.VEEG..I.FKKE....VPDEVAEWHY.VVEFPP..DSKQVTDIIKPKGK-DFVLVISGLVFAENHYRALHSLPPEKKRN...LIHKWKMD....LLFRKAEFRMV-..PDAENV...............QRIDFSI..PI.Y.LEE...............LT...KPKLFEALREIFKCKLYIMWN-l......
A0A9Y1ZA72_9EURY/6-148              ....................t-EDTIRGWIdNELV..E.SVDT....MPDPEADVNL.LVEMSN..---IMIHIIYREPG-GPILIGQEIEYDDQIQSRIQGLSESDRGE...LVSRVRET....LTTVPVIYGFTD.eTGANVHfa...........emQRIFLEC..RI.Y.PDS...............IS...QQTVMARLVDVWKAMRYLDD--lv.....
L0ABU2_CALLD/3-147                  .....................LKEEIIKWL.KEEN..L.EVSEi.piPKDAPIEWAI.NTMVNA..PFRVAISIQRPKGKTEKFAFTMAVKVAEQHKEKIIKMPEQERAN...MIGELLKN....LYMMCPSCITIF.qPDINNP...............DNIIVTK..II.Y.QDK...............IT...PSEVTDSVRILSNAYGLIVTHF.......
A0A654LZM7_9ARCH/8-139              ..................isl---RIKRWL.VEESdiW.RFDE....IEDPSVVMNL.VAKSNN..---RNVNIIVDDLH-DKVTLITSMNFSKQQKNSLSLLPSKEKNR...FIPDLLMA....LYQLGLLARHSN..SSKDKI...............EKFIMEK..LI.Y.FDG...............LT...KDKFFDSLFTM-----------llgi...
A0A8D5U2P3_9CREN/3-144              ....................v-QEKVEKWL.RQMK..F.TISN....TPNAKEYYNV.TVSPPP.pAQFPILQVIIPEQSSPFVLILMGVGIHPQHVKGVKDMNDSERGK...FLNDIKYT....LLRMNVDFTFIP..PQDVIP...............QAISVSK..SV.Y.TDG...............LT...MDRFFDVFTLVRNAGLYIITKF.......
E3GWF4_METFV/3-140                  .....................IKEKIREWL.LEED..M.YKEE....MSDKSANFHF.LIECPP..--GHYMDVIQPLGKSDVIIVGCATKVSPEHVQKLRDLNRKERRE...FMWDIKFS....LNKFLVDFEIQ-..ENDDVL...............QGYVVRD..VI.Y.KDG...............LS...KDKLMSTIKRVFKAKLHVLWKI.......
Q97V42_SACS2/6-136                  ....................s-DSEVFNWF.KELG..M.RVEQ....VKSGDLYFHF.TVAPPM..-GGLPVSVIRPRPDSTYYIVAVLLELDQERLR--------NNKR...LVEQIKRE....LLRMNVEFFFT-..PNDKEP...............KSIQVAR..LM.F.TDG...............LT...KNEALNNVTLVKNSALLVLQL-i......
A0A654LZH1_9ARCH/9-148              ....................v-YNTILQWL.RDYS..Y.TIKDe..nMRTSSSEYYA.KVFPPN..QDIKFFEIVSDADLKDGFLLRMSVAFNPKDRSDFEHLKEEVQNN...LFIRIHKI....LSPIRLLCKIEN..------...............SVISVEK..YL.F.VDVn.............sIE..cKQYLWDSVIEMSNAMYLIELTF.......
H2C7B0_9CREN/7-146                  .....................MEEKVREIF.TNLK..M.SVSV....PPQAREFFHI.TVTPPQ..-GGPILDVIRPTNQTPFYILGMGIGIHQYHQDSLRRMDTASRKE...FVDSIKYY....LLEMGVDVAFLP..PNQDIP...............QLIHVSK..LV.F.MDG...............LT...PNVLLDVYYTVRNAGTYVIMRF.......
O30261_ARCFU/1-137                  ....................m----VRDWL.VEEG..I.YKDK....VADENADYHF.LAEIPP..NSRQFIDVVFPKNRDDMVVVASGIRLSDEHYRSLMSLNAEKRNE...LLWKMRFD....LLFLPTGFQIL-..PNVDDP...............QLFQFTR..EL.Y.FDG...............LN...KNLFMDAIKQVHRCKLYVIWTM.......
D5U0M1_THEAM/5-152                  ....................a-YELISKWL.VEES..F.TIRRl.eaPPEAKILWGL.DVFTPG..QPSVNFKIINPADKPDRVLIVLGIGISPDHRRELDKLKQTEKLK...VISNILGK....ALSVCIDCQITV.qPNMIDP...............QALSILL..AL.F.NEE...............IAlygKPYFMRLVARTLNTYFAIISGF.......
#=GC seq_cons                       ......................cpplpcWL.p-.u..h.phpc....s.ssptpFph.hlp.st....s.slcllpscsptshlllshsltlssp+hptlpphpppc+pc...hltclphp....Lhphslphphh....stp.s...............ptlplsc..hl.a..Du...............lo...csphhssltplhputhhshhh........
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