#=GF ID   DUF356
#=GF AC   PF04009.19
#=GF DE   Protein of unknown function (DUF356)
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   COG1844
#=GF GA   32.70 32.70;
#=GF TC   38.20 81.10;
#=GF NC   27.10 26.00;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR007154;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Members of this family are around 120 amino acids in length and
#=GF CC   are found in some archaebacteria. The function of this family is
#=GF CC   unknown. However it contains a conserved motif IHPPAH that may
#=GF CC   be involved in its function.
#=GF SQ   51
#=GS A0A0E3WZ28_METMT/1-82    AC A0A0E3WZ28.1
#=GS Q0W258_METAR/4-109       AC Q0W258.1
#=GS A0A328SI35_9EURY/3-108   AC A0A328SI35.1
#=GS A0A401HNX8_9EURY/3-107   AC A0A401HNX8.1
#=GS C5A3Y9_THEGJ/5-110       AC C5A3Y9.1
#=GS A0A8J8C985_9EURY/3-107   AC A0A8J8C985.1
#=GS A0AA51UFF0_9EURY/8-113   AC A0AA51UFF0.1
#=GS A0A328RX65_9EURY/3-108   AC A0A328RX65.1
#=GS Q2NF14_METST/3-108       AC Q2NF14.1
#=GS Q8TIP3_METAC/4-109       AC Q8TIP3.1
#=GS F7XQP6_METZD/10-115      AC F7XQP6.1
#=GS A0A4E0PY79_9EURY/8-113   AC A0A4E0PY79.1
#=GS A0A0U3DKF5_9EURY/3-108   AC A0A0U3DKF5.1
#=GS A0A964DBD2_9EURY/4-107   AC A0A964DBD2.1
#=GS R9SKC6_9EURY/3-109       AC R9SKC6.1
#=GS A0A328SEW6_9EURY/3-108   AC A0A328SEW6.1
#=GS A0A166BKY4_9EURY/3-108   AC A0A166BKY4.1
#=GS A0A166E3N6_9EURY/3-108   AC A0A166E3N6.1
#=GS A0A366MB08_9EURY/3-108   AC A0A366MB08.1
#=GS Q8U0G4_PYRFU/5-110       AC Q8U0G4.1
#=GS F0TCP4_METLA/3-108       AC F0TCP4.1
#=GS C6A2M1_THESM/1-106       AC C6A2M1.1
#=GS U6EBL1_9EURY/3-108       AC U6EBL1.1
#=GS A0A2U1S8H9_9EURY/3-108   AC A0A2U1S8H9.1
#=GS A0A0E3NYI3_9EURY/4-109   AC A0A0E3NYI3.1
#=GS Y949_METJA/3-108         AC Q58359.1
#=GS A0A916HN38_9FLAO/14-119  AC A0A916HN38.1
#=GS D7DUN4_METV3/3-107       AC D7DUN4.1
#=GS A0A1Q6DTQ1_METT1/4-109   AC A0A1Q6DTQ1.1
#=GS A0A166B0K3_9EURY/3-108   AC A0A166B0K3.1
#=GS A0AA43UG33_9EURY/3-108   AC A0AA43UG33.1
#=GS L0KY50_METHD/10-115      AC L0KY50.1
#=GS A0A8J8C1I2_9EURY/5-107   AC A0A8J8C1I2.1
#=GS D7E629_METEZ/4-109       AC D7E629.1
#=GS O26826_METTH/3-107       AC O26826.1
#=GS A0A1D3L034_9EURY/3-108   AC A0A1D3L034.1
#=GS A0A1V6N111_METAZ/3-108   AC A0A1V6N111.1
#=GS A0A484F3I9_9EURY/4-110   AC A0A484F3I9.1
#=GS A0A2R6T636_UNCAD/4-109   AC A0A2R6T636.1
#=GS A0A1D2WA76_9EURY/3-108   AC A0A1D2WA76.1
#=GS A0A328S602_9EURY/3-108   AC A0A328S602.1
#=GS D5E9I0_METMS/4-109       AC D5E9I0.1
#=GS F6BD23_METIK/3-107       AC F6BD23.1
#=GS W0I7J0_9EURY/5-110       AC W0I7J0.1
#=GS A0AAE4MJ63_9EURY/4-110   AC A0AAE4MJ63.1
#=GS Q8TY52_METKA/2-107       AC Q8TY52.1
#=GS A0A126R0N0_METOL/3-108   AC A0A126R0N0.1
#=GS Q6LX79_METMP/3-107       AC Q6LX79.1
#=GS A0A328PHS1_9EURY/3-108   AC A0A328PHS1.1
#=GS Q5JFF5_THEKO/5-110       AC Q5JFF5.1
#=GS H8I766_METCZ/4-109       AC H8I766.1
A0A0E3WZ28_METMT/1-82               .------------------------MKFGSNPKRIEPSYADQLLVSVSGVPLKAKCNSAALVELDTNAGAAISKLRKIHPPAHVVIVSPRHDA-FEELADSSELYPEF..
Q0W258_METAR/4-109                  .FAVIRADDQTKLNTAISDLQRHGGLTFAIAPKELKPASADKILVNVMKVPLKKSCRAAALVSLNDDPGVAIDVLGRIHPPAHVIIVSSRHD-VYSKITDCITRLPDL..
A0A328SI35_9EURY/3-108              .LILIRAMNKKKALNCLADLERHANLTITGKPKAISLDKIFDVTKRVIKQNPRNDIKVAVLVKVNEKTTDSILSIRKIHPPAHVIVVSEEYPE-YAALLKDYNKAKVF..
A0A401HNX8_9EURY/3-107              .LLLIRGDNYKKIKNALADIHRHGKLTILGKPRIIVPEAADEILKYILG-TIKKPCKRACLVRIQESAPKAIDRIRKIHPPAHIVVISEKYEP-YYYLMRDLPKMPVL..
C5A3Y9_THEGJ/5-110                  .IVLVRTDNFQKASVALADLVRYGGMRIRGDPRIIPPALSDWAFEKISGEKPRKRFKAHVVAQIDLPPKKAIGRLMDIHPPAHILVIPPDSE-VWEELMRLWGSFEKL..
A0A8J8C985_9EURY/3-107              .LLLIRGDNYEKIKNALADIHRHGKLAILGKPRIMVPEAADEILKHILG-TIKKPCKRACLVKIQENAPQAIDKIRKIHPPAHIIVISEIHEP-YPYLLEDFPKMPIL..
A0AA51UFF0_9EURY/8-113              .FAVIRGDNADKVNVALHDLEHYGRMKFLSKPKRIEPLYADNLLVSVAGVPLRAKCNSAALVELDNNAGAAISKLRKIHPPAHVVIVSPRHE-VYEELMDKSELYPEF..
A0A328RX65_9EURY/3-108              .LILIRAMNRKKALNVLADLERHAKLTIDGKPKTVSSEDVYEVTKRVIKQKPRDDIKVPVLVQVKENTTTSIVNIRKTHPPAHVIVISEEYPE-YEGLMDVFEKAKVF..
Q2NF14_METST/3-108                  .LILVRAMNKKKALNGLADIERHAKLSIIGKPRKVSLKSVHDVTKRVLKQEPRDDIKIAVLVKVQESTTTSIMNLRKIHPPVHVIVISEEYPE-YEDLNKEFSKSKIF..
Q8TIP3_METAC/4-109                  .FALVRADDSDKVKIALHDLERYGHIQFSATPKCIEPNYADELLVSVMGVSLRSKCNSAALVELNNHAGAAISRLKKIHPPAHIIIISPRHK-MFEELAGKFQKYPEF..
F7XQP6_METZD/10-115                 .FAVVRGDNTDKVKIALHDMQQYGHINFLSEPKYIEPEFADNVLVSVMGVPLKTRCSSAALVEVGSNAGAIINKLRKIHPPAHIVVVSPRHG-VYSELVEKAEEYPEF..
A0A4E0PY79_9EURY/8-113              .FAVIRGDNPDKVNVALHDLEHYGHMRFASKPKRIEPNFADNLLVSVAGVPLRAKCNSAALVELDNNAGAAISKLRKIHPPAHVVIVSPRHD-VYTELMDKSELYPEF..
A0A0U3DKF5_9EURY/3-108              .LILIRGENKSKLLSAISDMERHGSLTLLSKPKVISAEFADSLVEQILKSKLRTKSNVATAFFVKEDTTLSILKIKQIHPPAHIVVVSPEYRG-YEELKEKLTIAHD-m.
A0A964DBD2_9EURY/4-107              .LAIVRATDILKLKTTLNEM-KQAGLLFEGHPKEINPGSIEKALSNDSG-ISNSIYEVCALVPINQDFQSFQDKIEAISRHSNVKILDPTHS-LYNNLANMIPILPDL..
R9SKC6_9EURY/3-109                  .LILIRGENNSKVLNAISDVEKHGGLHLTSKPRALDANIADNIVSKILKADIKNESKVAAVFSIQENPTLAISKIRSIHPPAHIIVVSDEYDEIYEDLLNKMDEAKYF..
A0A328SEW6_9EURY/3-108              .LILIRAANKKKALNALADIERHAKLTIDGKPRLLDVDEAEDVTRSILKQKPKSVVNLAVLVRVQESTTTSIMNIKKIHPPAHLIVISEEYP-VYEGLNKKFSSLKTF..
A0A166BKY4_9EURY/3-108              .LILIRGENNSKILNAIADIERHAKLNIKTKPKAIDSKIADSIVESILKSPLRSKSKVATAFFVEEDITLSIMQVKTIHPPAHVIVVSDEYEE-YSRLEGALGDSD--nl
A0A166E3N6_9EURY/3-108              .LILIRGDNNSKLLNAIADIERHAKLNLIAKPQKIDSNFADKIVESILNSPLRTKSKVATSFFIKEDITLAIMQIKKIHPPAHVVVVSDEYED-YEKLREVLNDAPIF..
A0A366MB08_9EURY/3-108              .LILIRGDNNSKLLNAIADIERHAQLHLMNDPQKIDAEFADSIVESTLKAPLRNKSNVATTFFVREDITLAIMQIKKIHPPAHVVVVSDEYKE-YESLNKKLDEAPVF..
Q8U0G4_PYRFU/5-110                  .IVLIRTDNFDKALTALADLVRYGGMKIRGTPRIIPPALSDWAFEQIVGEKPKKKVKAHVVAQIDLPASKAIGRIRDIHPPAHIIVIPVGSP-VHKELLRLWGTFKEL..
F0TCP4_METLA/3-108                  .LILIRAEDQSKLLNTLADIERHAGLKISGKPRIMDSKKADNIATKILKQKIRSRSAIAVLVKVVDDTTKSIVHIRKIHPPAHVVVISEEYAE-FKELEANFNKLSP-l.
C6A2M1_THESM/1-106                  .MVLIRTDNFDKALIALADLVRYAGMEIRGKPKIIPPALSDWAVEKIVGEEPKKKYRAHVVAQVDLPPAKAIGRLREIHPPAHIIVIPPDTP-VHKELLKLWGTFEVL..
U6EBL1_9EURY/3-108                  .LILIRAENQAKLLNSLADIERHAGLKINGSPRIIKNKVADKYAKSIMKDELRSKSKIAVLISVQEDATLSILRIRKIHPPAHVVVISEEYDQ-WKALQKLFNTLPL-f.
A0A2U1S8H9_9EURY/3-108              .LVLIRGENNSKLLNAIADMERHGNLNLACKPKMIDSRFADKLVEGILHSKLKTKSKVATAFFIKEDTTLSIMQIKKIHPPAHVVIVSDEYDA-YDKLKLKLERAPDF..
A0A0E3NYI3_9EURY/4-109              .FALVRADNSDKVKIALHDLERYGDIQFSASPRSIEANYADELLVSVMGVSLKSKCNSAALVELKNHAGLAISRLKKIHPPAHVVIISPKHK-VFEELSGKFRLYPEF..
Y949_METJA/3-108                    i-LLIRGDSYEKLKNALADVDRHAELTIIGKPKIIVPEAADEILSHILG-EVKKPCKTACLAKIAEKAPKAIDRIRKIHPPAHIVVISERYGDIYYKLLDDFPKLPVL..
A0A916HN38_9FLAO/14-119             .MAVVRADDASKVKIALYDLVRYANLTFSDQARKLEPTFADNILTHIMKSPLRGCCSSAAIVPLEDQASVAIGRLRKIHPPAHVIIVSPRHE-IYHELVNYVDILPE-i.
D7DUN4_METV3/3-107                  .LLLIRGDSYEKIKNALADVHRHAKLTIVGKPRIMVPEAADEILEYIVG-NIKKPCKKACLVKIEENAPRSIDRIRKIHPPAHIVILSERHEP-YSFLIDDFPKMPML..
A0A1Q6DTQ1_METT1/4-109              f-GLIRADDSEKLKKAIDSLDREIDVDLDKGPKRFNASRADDILTKVLDSPLKNECEYAALCKINEKASRAINIIQDTRPPAHIIILSQKHD-VYDQVRNSYNKLREL..
A0A166B0K3_9EURY/3-108              .LILIRGENNTKLLSAILDIERHANLSLTSKPKVIESIFADQLVESILKSPLRSLSNAACAFFVKEDITLSILQVKTIHPPAHVIVVSNEYPE-YDKLIDVLDTQEDL..
A0AA43UG33_9EURY/3-108              .LILIRASNKKKTLNTLADLERHAKLNINTKPRILDSKKAELVVETILKQKPKSSMGLSTLVKVKEKTPYTITQVMSIHPPAHVIVISEEYD-IYTKLESKFKDLDVL..
L0KY50_METHD/10-115                 .FAVIRADNADKVNVALHDLEHYGHLRFLSKPKRIEPQYADNVLVSVVGVPLKSKCNSAALVELDNNAGAAISKLRKIHPPAHIVIVSPRHK-VYEELVDKAELYPEF..
A0A8J8C1I2_9EURY/5-107              .YILVRADNSQKAMTALADLERYANIRIH-EPRLMPKHMAEDLISEFLN--LKSEKRVNFVVQVHMNPGEVIKRVRKIRPPAHIVVVTDRYR-TYEIMEANYHEFPK-i.
D7E629_METEZ/4-109                  .FAVIRGDNTDKVKIALHDLEQYGKFQFQAKPKQIEPDYADHLLVSVLRVPLKARCKSAALVELDDNAGAVISRLKKIHPPAHIVIVSPRHEA-YNELINKSKNYPVF..
O26826_METTH/3-107                  .LIILRADSRKKILNAIADLERHAGLKVRGKPRILRNDIADRMASSILG-ELRMKSSVAAAVEVEEDDTRSIMAIRRIHPPAHVIVVSSEYDE-YNDLREMFGGLRV-l.
A0A1D3L034_9EURY/3-108              .LILIRADNKEKLLNGIADVERHAKLKILGIPRVIPSESADNIVQEIIKQKLRSKSKKAVIVRVEEDTTKSIVNIRKIHPPAHLMVISEEYDA-FKDLEAKFKELKPF..
A0A1V6N111_METAZ/3-108              .LILIRGDNNSKLLNAIADIERHAQLHLIKDPQKIDGEFADSIVESILNAPLRNKSKVATAFFVREDITLAIMQIKKIHPPAHVVVVSDEYKE-YSSLNEKLDEAPIF..
A0A484F3I9_9EURY/4-110              .FALIRADDPDKVKIALHDLETYGHMQFSENPKNIATKYADQILTSVMSVTLKTECCSASLVRLETPPGAAISNLKKIHPPAHIIIISPRHEVIYEELASNYDNFPG-f.
A0A2R6T636_UNCAD/4-109              y-AVVRADNRSKLETALSDLEEHANLEIPETPKKIEARKADEILVEVLDSPLEQKCNDAAVCKLKEDPASVINTIKGIHPPAHVVVVSERHD-VFDVLNEDYGDLEAL..
A0A1D2WA76_9EURY/3-108              .LILIRANSQGKLLNAIADIERHANLKISGKPKIIEPQIADKLAKGILKQNLRSKCEIATLIKVLDDTTKSIMHIKKIHPPAHIVVISEEYKE-FEEIKKMFNILPVL..
A0A328S602_9EURY/3-108              .LILVRAMNKKKALNALADIERHAQLNFVDKPRKIGLDKIVDVTRRVIKQNPRDDIKVAVLVKVQQDTTKSIMSIKKTHPPAHIIVVSEEYPE-YKDLIGEYDSLKVF..
D5E9I0_METMS/4-109                  .FAVIRGEDKNKVRIALHDLQQYGSMKFSSCPKRIEPNYADTLLVKVVGVPLRSNCKFAALVGLENNAGSAINKLRKIHPPAHIVIISPRHDA-YEELMDNSEIYPEF..
F6BD23_METIK/3-107                  .LLLIRGDNYEKIKNALADVDRHAELTIIGKPRIILPEAADEILKHILG-EIKKPCKKACLAKIEESAPKAIDRIRKIHPPAHIVVLSERYE-MYEDLLRDFPRMPVL..
W0I7J0_9EURY/5-110                  .IVLIRTDNFDKAMVALADLVRYGGMQIRGDPKIIPPALSDWAFEKIVGEKPRKKYRAHVVAQIDLPPAKAIGRLRDIHPPAHIIVIPPGSP-VHKELLRLWGTFEKL..
A0AAE4MJ63_9EURY/4-110              .FALIRADDPDKVKIALHDLETYGHMQFSDSPKNIATKYADQILMNVMSVTLKNECCSASLVQLDTPPGAAISNLKKIHPPAHIIIISPRHEKVYDELMNNYGNFPDF..
Q8TY52_METKA/2-107                  .FVVIRSDSYEKILTSLSDIERYAGIKILGKPRIMDPEVADTIVRELLG-EVRRRYPVAAVARVEGEPAEVIRKISEIHPPAHLIVITPRHGDVYRGIARRFGKLEEL..
A0A126R0N0_METOL/3-108              .LVLIRGESNSKILNAIADVERHAKLNLTTKPKKIDAKFADKIVENILKAPLRTKSKVATAFRIKEDTATAIVQIKKIHPPAHIVVISNGYDD-YKELNKVLNDAKVF..
Q6LX79_METMP/3-107                  .LLIIRGDSYEKIKNAIADVHRHAKLTILGKPRIMVPEAADEILEHIVG-NIKKPCKKACLVRIEENAPRAIDRIRKIHPPAHIVIVSERHEP-YFYLLEDLPKMPL-l.
A0A328PHS1_9EURY/3-108              .LILLRADSRKKLLNALADIERHANLKMKGNPRLVDNKMADEIVSSILGGEVKRKSSVAVAVNVEEDDTTSILRIKEIHPPAHVIIVSKEYPE-NRLLRELIREAPI-f.
Q5JFF5_THEKO/5-110                  .IVLVRADNFQKASVALADLVRYGGMKIRGDPRIIPPALSEWVFEKVSGEKPRRKFKAHVIAQIDLPPRKAIGRLMDIHPPAHVLVVPPDSEA-WTELMRLWGTFEKL..
H8I766_METCZ/4-109                  .FAVIRADDPVKLNTAISDLQRHGGLTFAANPKQLAPADADRILVEVMKVPLKKQCKAAALVALNDDAGVAIDVLGRIHPPAHVIIVSSRHD-IYPKISECIKKLPEL..
#=GC seq_cons                       .llLIRuDNtpKlhsALuDlERaupLpltucP+hIssphADpllppllt.pl+scscsAsllplc-ssstuIspl+KIHPPAHllVlSscac..YccLhcphsphs.h..
//