GenomeNet

Database: Pfam
Entry: DUF4122
LinkDB: DUF4122
Original site: DUF4122 
#=GF ID   DUF4122
#=GF AC   PF13498.9
#=GF DE   Domain of unknown function (DUF4122)
#=GF AU   Ellrott K;0000-0002-6573-5900
#=GF AU   Bakolitsa C;
#=GF SE   Bacteroides thetaiotaomicron: BT_2607
#=GF GA   27.00 27.00;
#=GF TC   28.20 28.10;
#=GF NC   26.80 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   15790854
#=GF RT   Glycan foraging in vivo by an intestine-adapted bacterial
#=GF RT   symbiont.
#=GF RA   Sonnenburg JL, Xu J, Leip DD, Chen CH et al
#=GF RL   Science 2005 Mar 25;307(5717):1955-9.
#=GF RN   [2]
#=GF RM   16735464
#=GF RT   A hybrid two-component system protein of a prominent human  gut
#=GF RT   symbiont couples glycan sensing in vivo to carbohydrate
#=GF RT   metabolism.
#=GF RA   Sonnenburg ED, Sonnenburg JL, Manchester JK, Hansen EE et al.
#=GF RL   Proc Natl Acad Sci U S A 2006 Jun 6;103(23):8834-9. 
#=GF DR   INTERPRO; IPR025190;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Based on Bacteroides thetaiotaomicron gene BT_2607, a putative
#=GF CC   uncharacterized protein. As seen in gene expression experiments
#=GF CC   (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it
#=GF CC   appears to be upregulated in the presence of host or vs when in
#=GF CC   culture [1,2].
#=GF SQ   21
#=GS A0A1M4Z1N4_9BACE/48-258  AC A0A1M4Z1N4.1
#=GS A0A415ZK80_9BACT/1-193   AC A0A415ZK80.1
#=GS W0EQR2_9BACT/41-244      AC W0EQR2.1
#=GS A0A1Y4HGJ7_9BACT/53-255  AC A0A1Y4HGJ7.1
#=GS W4UWM2_9BACE/3-221       AC W4UWM2.1
#=GS A0A3N2KRM2_9BACT/37-241  AC A0A3N2KRM2.1
#=GS A0A373ZYJ8_9BACT/3-224   AC A0A373ZYJ8.1
#=GS A0A415DT83_9BACT/64-257  AC A0A415DT83.1
#=GS R5W6A6_9BACE/3-216       AC R5W6A6.1
#=GS A0A4Q0TXA0_9BACE/3-219   AC A0A4Q0TXA0.1
#=GS F3PYU2_9BACE/3-216       AC F3PYU2.1
#=GS A0A0F5JBQ2_9BACT/3-224   AC A0A0F5JBQ2.1
#=GS Q8A4J2_BACTN/3-221       AC Q8A4J2.1
#=GS A0A174QEL7_9BACE/35-256  AC A0A174QEL7.1
#=GS A0A3P1ZTW7_9BACE/82-260  AC A0A3P1ZTW7.1
#=GS A0A4V1L924_9BACE/1-193   AC A0A4V1L924.1
#=GS A6KY66_BACV8/3-218       AC A6KY66.1
#=GS A0A3N2KHE4_9BACT/43-242  AC A0A3N2KHE4.1
#=GS A0A0F5IPJ7_9BACT/1-193   AC A0A0F5IPJ7.1
#=GS A6LIR7_PARD8/3-175       AC A6LIR7.1
#=GS A6L0N3_BACV8/3-219       AC A6L0N3.1
A0A1M4Z1N4_9BACE/48-258             .................................lwkyrkkrmadkakrerrkkiygk------------------.---..-.-------.-DLPTDKPKPIQ..TETHKKV.E.ESPPvddDPNEVMGKSNII.YYeDINAARTI-PTHS-..-L..ELKQVELPVDKDVNPDDVEDNF--EPQKGL.TEEdmQElmEPEG...IM.PDP.D.F-D....TSMTY.EEMNNMVDVLS--SDTHSDEN-GLRAAQTiF.H.KLPGTELLRLIENELADQQKIDRLLFDYLDEFGRPLP...ESK.RRERK-------ikdfn.............
A0A415ZK80_9BACT/1-193              ......................................................mil-------KLSLTVLLLYY.LGV..LwKYYRQDI.AGMFGTAETDED..TDEPDQE.P.GQPG...EPYTVMGESTYLpFA.AEDGEEAAAGAVDE..PAaeDDGADYSDIEPEEDEEETDYEPTPEEIREL.-EE..DE..ELGA...YY.PDG.NpDFA....TGYSF.DDLKKVRRVLVSD-DAGEKAEREARE--V.L.P.SVMGSDIWEAM--------------------------...---.------------ldefegarervarlmdnh
W0EQR2_9BACT/41-244                 .....................iriarvrlwkyhkrrmeqaerrarkkakykkpgtdt------------------.---..-.-------.----------AK..EKSETAI.P.SSPP...EDDDVIGKTKIV.YL.EDPKTTTQIPTRSE..PM..EKVP--LEEEEDIGTDDVT----QENKGLT.EED..RA..ELMApvdTE.PDP.D.-FN....TALTI.EEINNVAEVLT---SGTTDEQKARRAART.I.HyKLSETEILTFLTDKLSNLDKVNGLLDKYLGD------...---.------------rpgpsgktghkeeep...
A0A1Y4HGJ7_9BACT/53-255             ....................rkkrivekagknsgktfagdsrgaavkddtgsparvd------------------.---..-.-------.------------..-------.-.--ND...TNDDVIGKTNIV.YL.EDPDMARRIPVRTM..EL..EKVA--IDQDEEINPDDVENGIGPGNGLTE.SDR..QD..LMAS...ED.SIP.DpEFS....KPLTF.EELNNVAEVLMS---ATDDRKNIQAAAET.L.Y.RLQDTDLFGFFSTEISTTAQVEKLLKEHLDSSGRLLSeteVSK.RNSKRNVID-W-n.................
W4UWM2_9BACE/3-221                  .........................................................EIVYLSVRLACVFYILYK.VWG..T.KKKVREI.CDLLYVKTPPVRtdKKESETI.L.PEAA...DESGVMGGTRFV.YL.DENAGKTAAPYMSQ..PL..DTG--YIGEDEDIPEEDVECQLPLEEMKIL.KEE..QE..DLDV...TS.PEV.D.PVS....GAVTP.ADLDNAGNVLFKLDHADQDEEKSRRAALT.L.Y.AIRETDLFEIFSSQVENKNVIENLMGKYLDGEGNALP...VRK.TMAGTFPSDEWK..................
A0A3N2KRM2_9BACT/37-241             ................................................lyrwarvir--------------IILQ.RWY..Q.KLEAARIeCRKRHE--MREK..RRKKEKT.V.PHSV...VDCEVIGKTKSV.YI.P-DPKKAREPVRSE..PL..P-ESDFIGEDEDISADDVDYTFTDDEDLSS.DLT..DA..DMQA...LM.APV.E.TEPdpdfPTGIPiSRISDAADVLMS---GTDNMEKRMRTAET.L.F.QLRDTDLFRLFAENICPQEELDMIITECLTHNGE---...---.------------rkafnedvpa........
A0A373ZYJ8_9BACT/3-224              .......................................................ty--FYFSVKTVCCGYLFYR.LWIflF.RQRIYGL.WEDMVKYLPKKK..EKPTEPV.T.ASKD...DDNEVIGKTNIV.YL.EDPEIACKVPARSE..PL..PPAEE-MEEEEDIAADDVESTFTGNPPGGLsEEE..KA..ELMS...DYvSEVdE.DFS....TGMTY.EDMMNAVGVLTEENRNTNDE-KVIRTVKS.I.Y.DIRQTEIFDFFTTEVSNIELVESLFKECLDEYGEPLP...QRK.KE----------appeseekfd........
A0A415DT83_9BACT/64-257             ......................................grktrhskkqfreplpdtv------------------.---..-.-------.------------..GQGTEME.A.SSPA...NGDDVIGKTKIV.YL.EDPEVARKTPTRSE..PL..KK--EPIEEDEEIRTDDVEDNFRQDDKRLT.DED..KR..ELMApvdSE.PDP.E.FVT....-AMTF.EDISNVAEVLMSEN---PDEQKAIRAAST.I.HhKMQETVILSFLTDKLSNQEKVNQLLSECLDDTGRPLT...RRK.STSKK-------keafdi............
R5W6A6_9BACE/3-216                  .........................................................ELIYFCVRIVCIGYLLYS.VYG..W.RRRIETV.CTLLYG-KPCVK..KEKKETV.V.TESA..vSDTEVMGSTRYV.YL.DENAGKTAAPFMSQ..PL..ER--NFIGEEEDVQQEDVECNLQLDKMKLL.QEV..QE..DLDA...ES.PEV.E.SVS....PVLSS.RDMEVLGEYLTHQDEA--DHEKAMQAARV.L.F.SIRQTSLIDVFLSNMENSAIVEELIDRYLDEDGNPRP...LKV.-KDGNEPSDEWR..................
A0A4Q0TXA0_9BACE/3-219              .........................................................EIVYLSIRLGCTAYLLYK.VWE..Q.KKRIGKI.CDLLYT---PRK..KPEMEKGhH.RNPE...NAADVMGATRFV.YL.DENAGKTVAPYMSQ..QL..EMGSDLIGKDEDIPEDEVECKLPLEEMRML.KDE..QE..ELDS...RS.PEA.E.AIV....PAVTP.ADLLNVGDVLLNLDGAGSDEDKSYRAAMT.L.R.AIRETDMFELFSSQVENKKLIEELMERYVDEEGNALP...LKKeRNVSKPVAD-WR..................
F3PYU2_9BACE/3-216                  .........................................................ELIYLCVRIVCIVYLLYS.VYC..W.RTRIETV.CTLLYG-KPPVK..KEKPEASgT.GAVA...SEDEVMGSTRYV.YL.DENAGKTAAPFMSQ..PL..EK--NFIGEEENVEQEEVECNLALEKMKLL.LQE..QE..ELDA...GN.PDV.E.SVS....PVLSS.RDMETLGEYLARKGEV--GEEKALQAARI.V.F.SIQQSNLIDIFTSNAENAKMVDELLDRYLDEDGNPKP...LPP.-KENENPADGWR..................
A0A0F5JBQ2_9BACT/3-224              .......................................................ty--FYFSVKTVCCGYLFYR.LWIflF.RQRIYGL.WEDMVKYLPKKK..GKSAEPV.T.APKV...DDNEVIGKTNIV.YL.EDPEIDCKVPARSE..PL..PPAEE-MEEEEDISADDVESTFTGNPPGGLsEEE..KA..ELMS...DYvSEVdE.DFS....TGMTY.EDMMNAVGVLTEENRNMNDE-KVIRTVKS.I.Y.DIRQTEIFDFFTTEVSNIELVESLFKECLDEYGEPLP...QRK.KE----------appeseekfd........
Q8A4J2_BACTN/3-221                  .........................................................TIVYLSIRLACACYILYK.VCG..Q.KKKIREI.CDLLYAKLPPVK..QKEPENV.L.SEPG...GESGVMGSTRFV.YL.DEDAGKSVAPYMSQ..PL..ETAADFIGEEEDVAEEEVECKLPLEEMRML.KEE..QE..ELDG...TY.PAV.D.AVS....RAVTP.DDLDNAGNVLFKLNDADKDEGKSLRAALT.L.H.TIRETDLFEIFSSQVENKNVIDSLMGKYLDGNGNPLP...VRK.TKSVVPVSDGWK..................
A0A174QEL7_9BACE/35-256             ekvyhmmriariklwkyrkeyriyrekkaekarkkarrkknvpetkvvqekpvtver------------------.---..-.-------.------------..-------.-.PSQV...DDNDVIGKTRIV.YL.EDPDVARKKPTHSE..PL..V--REPIEEDEEINPEDVV----QENKGLT.KEE..KE..ELMApvgAE.PDP.D.-FN....TAMTF.EEMNNVVEVL---TSATRDEQKAFRASMT.IyH.KLSGTEILNLLENEIGCQHKIGHLLNEYLDEAGKPLL...RRRgTPKKKEVFD---igk...............
A0A3P1ZTW7_9BACE/82-260             ......................................deplqlpveekpkpkikpv------------------.---..-.-------.------------..-------.-.-VFD...DPNEVMGKSNII.YY.EDPEVARKTPTRSI..EL..KQV--ELPVDEDVNPEDVEDNF-VPQKRLS.QED..MK..ELMS...SE.SIP.DpDFS....GACTF.EELGNVADVLLNR---TTDKKKIMDAAET.L.Y.KLQDSDIYHFYTTSISTEKQVDRLLRNNLDGAGRRLN...GKQ.------------lerteidw..........
A0A4V1L924_9BACE/1-193              ......................................................mil-------KLSLTVLLLYY.LAV..LwKYYRQDI.AGIFGTAETDED..TDGTGKE.P.GQPG...EPYTVMGESTYLpFG.AEDGEEAVAGAVDElaAE..DDGADYSDIEPEEDEEETDYEPTPEEIREL.EE-..EE..ELGA...YY.PDG.NpDFA....TGYSF.DDLKKVRRVLVSDNADEKAER---EAREV.L.P.SVMGSDIWEAMLDEFE---------------------...---.------------garkrvarlmdnh.....
A6KY66_BACV8/3-218                  .........................................................EIVYLSIRFGCTAYLLYK.VWK..Q.KERIGKI.CDLLYT---PRN..RPQAEKD.N.GEPG...NAQDVMGATRFV.YL.DENAGKTVAPYMSQ..QL..ETGSDFIGADKDIPEDEVECKLPLEEMRML.KEE..QE..ELDS...RS.PET.E.AIA....PMVTP.ADLLNVGDVLLNLNGAGSDENKSYRAAMT.L.H.SIRETDMFELFSSQVENKKLIEELMGKYVDKEGNALP...LKReRKESKHVTD-WR..................
A0A3N2KHE4_9BACT/43-242             ...............................iirimmwrwhkrritskaerrkrstv------------------.---..-.-------.---------RNQ..KKKKEAA.A.VAPS...TYCEVIGKTKSV.YI.P-DPKKAKEPVRSE..PL..P-ESDFIGEDDDISADDVDDILEPMDDRDL.QEL..ME..P--G...LS.EAD.P.DFS....QAMTY.DDINNMVAVA---TGANKDETDTIRAVET.L.Y.SIRQSDIYEFILSESDNKDRIERLINERFDENEASHS...TPE.R-----------peektssfdws.......
A0A0F5IPJ7_9BACT/1-193              ......................................................mil-------KLSLTVLLLYYlVVL..W.KYYRQDI.AGIFGTAETDED..TDGTGKE.P.GQPG...KPYTVMGESTYLpFA.AEDGEEAAAGAVDE..PAaeDDGADYSDIEPEEDEEETDYEPTPEEIREL.EE-..EE..ELGA...YY.PDG.NpDFA....TGYSF.DDLKKVRRVLVSDNADEKAER---EAREV.L.P.SVMGSDIWEAML-------------------------...---.------------defegarervarlmdnh.
A6LIR7_PARD8/3-175                  ......................................................sms------------------.---..-.-------.------------..-------.-.PEPA...DEKEVMGKTRFV.YL.DENAGKTAAPYMSQ..PL..EQGTDYIGEDEEIREEDVECLLPLEEMELL.RKE..QE..ELDS...TL.PET.E.VIT....QAVTL.EEFSLVGDVLMRVNGADQDADKRSSAART.L.F.AIRNTSLFDLFISQVGNEEAVNKLLEENLDEDGNPRP...LKKgGKRNNGGVD-W-r.................
A6L0N3_BACV8/3-219                  .........................................................EIVYLSIRLGCTAYLLYK.VWE..Q.KKRIGKI.CDLLYT---PRK..KPEMEKD.HhRNPE...NAADVMGATRFV.YL.DENAGKTVAPYMSQ..QL..EMGSDLIGKDEDIPEDEVECKLPLEEMRML.KDE..QE..KLDS...RS.PET.E.AIV....PAVTP.ADLLNVGDVLFNLDGAGSDENKSYRAAMT.L.R.AIRETDMFELFSSQMENKKLIEELMERYVDEEGNALP...LKKeRNVSKPVAD-WR..................
#=GC seq_cons                       .......................................................................lhh..hh.....+..h.tl.ht.hht.....c..pcp.-t....spss...sss-VMGcT+hV.YL.--ssscstsPshSp..PL..-pst-hIsc-EDIsp-DVEsphs.Ech+hL.cE-..pE..ELtu...p..P-s.-.shu....suhTh.-DlpNlu-VLhp.stuspDEpKshRAApT.L.a.slppT-la-hasoplpNpchl-pLhpchLDctGpshs...hpc.t.............................
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