#=GF ID   DUF4895
#=GF AC   PF16236.11
#=GF DE   Domain of unknown function (DUF4895)
#=GF AU   Chang Y;0000-0002-2418-3433
#=GF SE   Jackhmmer JCSG target TM0928
#=GF GA   25.00 25.00;
#=GF TC   25.60 44.60;
#=GF NC   23.50 22.70;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR032606;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A small family of uncharacterized proteins around 250 residues
#=GF CC   in length and found in various Thermotoga species. The function
#=GF CC   of this family is unknown.
#=GF SQ   18
#=GS A0A5D0SLL1_9BACT/32-260  AC A0A5D0SLL1.1
#=GS A0A0C7NKU6_DEFTU/12-247  AC A0A0C7NKU6.1
#=GS A0A1L7BE35_9BACT/31-249  AC A0A1L7BE35.1
#=GS A0A1G6PXF9_9BACT/13-255  AC A0A1G6PXF9.1
#=GS A0A0G2Z6L2_9BACT/31-259  AC A0A0G2Z6L2.1
#=GS A0A1M5RTT7_9BACT/27-248  AC A0A1M5RTT7.1
#=GS A0AA45HHK5_9BACT/13-248  AC A0AA45HHK5.1
#=GS A0A5D0TCJ4_9BACT/32-261  AC A0A5D0TCJ4.1
#=GS A0A328IM82_9BACT/32-263  AC A0A328IM82.1
#=GS A0A7G1G5K3_9BACT/12-249  AC A0A7G1G5K3.1
#=GS Y928_THEMA/18-231        AC P56728.1
#=GS B7IG51_THEAB/31-252      AC B7IG51.1
#=GS A0A0X1KTR1_9THEM/29-248  AC A0A0X1KTR1.1
#=GS I2F7F2_9BACT/32-252      AC I2F7F2.1
#=GS F7YVY7_9THEM/29-248      AC F7YVY7.1
#=GS A7HN20_FERNB/25-258      AC A7HN20.1
#=GS A8F8B9_PSELT/26-246      AC A8F8B9.1
#=GS C5CI15_KOSOT/32-237      AC C5CI15.1
A0A5D0SLL1_9BACT/32-260             .......ltereelletrfghfc--------------..TTIVRDS..F..SKF.............PVLSFFVDSEGKSFFGISSSSPLETSSAIYRFTDlTLLEKSMSIYKELFP..E.....Tv...sQK.....V.....Q..RVILQYPLKLNFIAICGNERLIRREKLKDTMSGTNYMTLSEKINDS....LYKIL.LE.AFRKWISF....PKG..sVLvfpYQDKI..KYALgIPNLDYRV.DSSIIIEFSRLFRKAVT--.....-.......-----.....--------------------..----------dklaflkqtsvtpdmnlnttvatvfesnllhaekiinkl.......
A0A0C7NKU6_DEFTU/12-247             .......................LEKYNSLLADEFQH..YFFASVF.dK..SNT............fPVYTILVDKEGRNIEILGPDHPSKVMSVLYPTLF.PNAIFLETKYKEIAQ..K.....Y.....KK.....IvypetS..FGIVQSPLKLVAYRAYGDERFIKKLIFTEKLKGQNYLSLSMSINDKtlqfIIDHF.KK.WVDGVFYF....--P...YL...SDIHI..-VYK.LPENIESN.KVSIYIELGRMLKEKVLKKytfleN.......SYKLPe..mkIKEPVIAVFKIPADKITEVD..FQ--------elyetmieki....................................
A0A1L7BE35_9BACT/31-249             .....................ly--KFEDVLDVFHKH..LILVTVG..S..NGI.............FFLNAGYNPDGKFFFGVSLSNPFLRTPSLYKME-.YFNEDFENLYINSFS.tR.....K.....IP.....F.....M.tAGILKFPIMTHFLALGGEKSLISKELFSEEVSGKSWLNFSKKVDDK....TYDEL.LA.LNGKNYYF....LKT...FL...TDDGV..YFVG.IGE---GE.HKNLYAEFFSFLRNKYKFQ.....P.......GKYFPi..sdMKDKVIGMFKVDLEDLKEKW..RYVESFVDDF..............................................
A0A1G6PXF9_9BACT/13-255             .......................LKKYKDKIADEFDH..FYSVWVYdkY..EKF.............PVLSYFTDQEGRVIRALTPETPSKVMSSLYPKQV.EYENELKEEYKKIAE..E.....KgfvvePI.....V.....K..SSIVQSPFKVCAYKLSGDERLIKKLLFSEKIKGLNYFSLSEKITDE....IFEFIlNN.YKKYDEGI....FYF...PY...MNE-I..HLFMkLPEGVPTE.WKSLYIDIARVLKTKLIEKyd.fvEss...ykLPEMG.....IKDHALCVLKIPTNKILDLD..----------fkniyqqflkkiekqieei...........................
A0A0G2Z6L2_9BACT/31-259             ...lrdrqsvlgtefghfitsiv--------------..----DDA..R..DSA.............PTLSLFIDEEGRGFLGLSSVTPMKRMSSIYRYPPsRVTEALSKLYKKLFP..E.....A.....KV.....T.....V.sRIILQSPLRVHFVAFCGNERLLKREMLKASLAGRNFYKVAEKMDDE....LFDFY.CK.YFKRWVKL....RHG..eIFvypTEDRV..KIVTgLPRLSHNL.DLSIIIELSRLFRSLV---.....-.......-----.....--------------------..----------vkkqnilrasnvspdmnfsgvatsayevdlidslevyrnle.....
A0A1M5RTT7_9BACT/27-248             ......................l-YNYKEKLDVFHKH..LILISIY..L..QNN.............FTLVVGSNPENKVIYGVTISNPFERTPSLYKIKD.YYNEELANFYNTIFEssK.....I.....PK.....V.....Q..AGILRFPIQTHFLAVGGDKTLVSKEMFNEEVTGKPWLNFAKKVDNK....MYEKI.IE.LSNGHIDF....LRS...FV...TDDGV..YFVG.LN---DGD.FRNLYAEFFSFLRNKYKFS.....P.......GKFFPi..sgVKEKVIGMFKIELEDINNAQ..----------ifdkinmfiedf..................................
A0AA45HHK5_9BACT/13-248             .......................LSKYKNKLADEYDH..LFHVCIA..D..SENk...........vPCLSYFVDEQGRVFKTISAEPPKKVMSCLYPVDI.DFKNELSDEYELFLL..K.....N.....NKvankvF.....Y..SGIVQSPFKFYPYILEGDERLIKKMKFKEKLNGEKNLSFDEIIDED....TFEQI.MKkYKIISDNI....YYH..pYL...D-KIH..IVFL.LPKNIDIE.KRGLMIEISRCLKNKI-LK.....NfdfletsY---KmpdmnLKDPALCAFKLRA-------..----------dyiknidfediyksminei...........................
A0A5D0TCJ4_9BACT/32-261             lverealletrfghfctttvrds--------------..-------..F..SKF.............PTLSFFVDSDGKSFFGISSSSPLETSSAIYRFSDiPLLEKIKTIYKNLFP..D.....Sa...sQK.....V.....Q..RIILQYPLKLNFLAICGNERLIRREKLKDTMSGTNYMVLSEKIGNS....LYKKY.LE.AFRKWINF....PNGsvyVFp.yQDKVK..YALG.IPNFDYRI.DSSIIIELSRLFRKAVTEK....vN.......-----.....--------------------..----------flnqtsvtpdmnlnttvatvfesnlldadklidrmd..........
A0A328IM82_9BACT/32-263             ....................vve---RSDRLDNAFGHfmTLVVQTS..K..GNA.............PVLSVFVDSEGRGFVGLSNSSPFETASALYRFSN.EEEEPIVDDFSSVFE..E.....G.....AE.....L.....VfhRAIFQSPLKLYFLAYYGNERLLRKEILKDSLRGKDYFRLPEMIDDA....LFSIC.RD.NYRRWIEFd..dGEV..lIF...PFQNI.lKIAF.GPPKINESiDRSIILELSRLFRI-----.....-.......-----.....--------------------..----------evtkkcgvlrnasvtpnmkiarpvstvfeidlveskpvydrlekfy
A0A7G1G5K3_9BACT/12-249             .......................LKNNKGKLADEFQH..LVYITVH..DkdDKF.............PYITYYIDEEGRYLKVFGPDSPKSVMSTMFNIVS.KNTEKIEKDYVNIAE..NygisvK.....TE.....I.....I..GGICQSPFKVYAYKLEGNETLIKKLTFSEKIRGERYFSLYKYMTEE....KVNFI.VKnYKKWNSNV....FFY...PF...NGEVN..IVFL.MPKKYSFS.QKALATEIGSIFKDKIILKy...eN......iQKTYKdpamkINQRILSIFKVKVEDILKYN..F---------lelyvdfikkidk.................................
Y928_THEMA/18-231                   .......................LKDYESKLDNVHLH..TFVLRIK..R..HRF.............PSLFLMIDTSDRRLLNLSVEDPFDREPCIYRVEA.DVPESMVSFYTKLFE..K.....V.....DS.....V.....S..AGIFRMPLKVKVLRSAGNESWLQKIFLQEKVKNMEFFLFQNRVSDE....NLEKM.MK.LLKSRLKI....---...VL...RNEGI..DVFLeTPEWVDKE.HISLLHEMGVVLRKKKGIQ.....P.......A--QN.....PMEQAFLTLRVGYDQFFEED..FDMEYFAKDF..............................................
B7IG51_THEAB/31-252                 .......................LNSYKEKLDVFHKH..LILVTVS..S..DND.............FALSAGFNPEGKFFYGISITSPFLKSPSLYKIKE.YVNEEFEALYNTIFN..K.....St...iSK.....V.....Q..AGIIRFPLQTHFLAVGGEKSLVSKEMFSEEITGKPWLNFAKIIDNE....AYEKI.MN.INGKKIGF....LKM...SL...TDDGI..YFFG.I---INDP.HKNLYAEFFRFLKEKYKLP.....S.......GKYYPv..meIKDKVVGTFKLELEEIFSEEkwKILEKFIDDF..............................................
A0A0X1KTR1_9THEM/29-248             ......................m-EVFKEKLDQYHRH..ALLFCTG..N..PDN.............FHLFVAVDHLARRMVGVSIVNPFEKNLPIYSLQL.T--VPIDDVYEKLFS..V.....Q.....SN.....Y.....H.kCGIVRLPFKFKMISGLGDEDFLAKEIFKEKVYGERKLSFAELINDS....IYKQL.VS.LNNSSIDL....MTI...RL...LDEGI.lCLLR.APNEVERS.RVPLLAEMAQILKSRYRFAc..eaK.......FKSIT.....STSPILTSVCIEYDKFFSG-..FDVQTFCHEF..............................................
I2F7F2_9BACT/32-252                 .....................vg--DHSDRLDNAFGHfmTLVVQTS..K..RNA.............PVLSVFVDSEGRGYVGLSNSSPFETASALYRFPN.EVENPFMEAFASFFG..D.....E.....TE.....L.....TyhRAIFQSPLKLYFLAYYGNERLLRKEILKDSLRGKDYFRLSEVIDDT....LFSIC.RE.NYRKWIEFd..dGEV..lVF...PFQNIlkIAFG.LPKINENI.DRSITMELSRLFRIEVTKQ.....-.......-----.....--------------------..----------cdvlrnssvtpdmnisrpvatvfeidlvds................
F7YVY7_9THEM/29-248                 ......................f-QKHKERLDQFHRH..AVLSAVW..K..ENH.............FSVFSLIDIYGRKILGISLSNPFEKNLSLYSTS-.NVDFLLSEIFSKLFD..Q.....Q.....PQ.....F.....Q.kSAVIKLPFQSKAIAVVGEDEFLEKEIFKEKIHSLSFFTFASKINEE....LYEKF.RR.WNGKKVDF....AQI..hLF...DDFAT..CVIT.IPKSAPLD.HASLLAEIARVYRPMYGQAy..qgN.......VKRFG.....-NSPILTIFTVDYNQLLEG-..LDLEAKCSQM..............................................
A7HN20_FERNB/25-258                 .......................LESKKDRLDVYHRH..VAVVTCY..S..NEHseinptesqkkfpFFMNLLVTPSNEKLIGLSISNPMSTNPAIYKLQKmKDEENFKEKFKNFTN..E.....N.....CN.....L.....Q..CGIIKLPLKTRFVAIAGSDEFLKKEIFSEKVLGTESFSFAQKVDEK....IIERL.EK.YKEGKFKI....CKT...II...NDEGI..NFFV.IDRSVSDE.FRPLLSEVVSLLRKKHNLS.....P.......AKYFA.....LNEKVIGSFTLDFNTIFSENpfVQVEKLIEEY..............................................
A8F8B9_PSELT/26-246                 .......................LEFYKEKLDQYHKH..VLLSTVG..A..ENN.............FYVFSFVDSSKRRVVGVSIANPFEKNLFIYNSD-.LEPSCLKEVYFELFE..K.....A.....PQ.....F.....M.rSGIIRLPFQSRVLSVVGDDDLLEKEILKEKVYGSENLSFAKKIDQR....IFDRF.CE.LNAKEIDF....ARI..yFL...SDYAV..CILV.LPDDIDTQ.YAPLLSEISRIYRKRYGAVy..qgN.......FGKFK.....RFSSILTAFVIEYNEILKG-..RDVEKDCLEL..............................................
C5CI15_KOSOT/32-237                 .......................LKNKEDVLETSFGH..FLTTIVQ..DelEMF.............PVLSLFVDSEGRGFFAISSTSPYETTSSIYRVEEsKVSEPLMELYRNLFP..E.....S.....TE.....L.....KivRTILQAPLRLYFISYLGNERLLKREILKDSISGKGYLRLAKEIDDE....LYDIY.VK.TFRRWIQFkwgdSFI...FP...YQDRV..KIIFgIPRLRKEI.DISTIIELSRFVRTKL---.....-.......-----.....--------------------..----------iekydtlkpssitpdmk.............................
#=GC seq_cons                       ........................ppac-+L-s.apH..hhllslt..p..spt.............PsLohhlDs-GRthhGlSsssPhcpssulY+hp..phpEplpchYpplFp..c.....p.....sp.....l.....p..suIlphPlKhphlulsGsEcLl+KEhhpEclpGpsahshuccIs-c....la-ph.hc.hhcpplpF....hph...hh...ss-sl..hlhh.lPc.hppp.cpuLhhEluRlhRp+htht.....s...................p.hls.hpl.hpph.p............................................................
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