GenomeNet

Database: Pfam
Entry: DUF5741
LinkDB: DUF5741
Original site: DUF5741 
#=GF ID   DUF5741
#=GF AC   PF19012.3
#=GF DE   Family of unknown function (DUF5741)
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Jackhmmer:W6U398
#=GF GA   25.00 25.00;
#=GF TC   25.50 29.90;
#=GF NC   24.40 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR043979;
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   This coiled-coil is found in various Platyhelminthes, with many
#=GF CC   of the sequences annotated as being uveal autoantigen with
#=GF CC   coiled-coil. This region is one of the numerous coiled-coil
#=GF CC   regions which constitutes this antigen. The function is
#=GF CC   currently unknown.
#=GF SQ   44
#=GS A0A3P7SY13_RODNA/844-925    AC A0A3P7SY13.1
#=GS A0A5K4ELH8_SCHMA/1393-1468  AC A0A5K4ELH8.1
#=GS A0A5K4EMI9_SCHMA/1393-1468  AC A0A5K4EMI9.1
#=GS A0A0R3SIR5_HYMDI/878-959    AC A0A0R3SIR5.1
#=GS A0A430Q675_SCHBO/1391-1460  AC A0A430Q675.1
#=GS A0A4S2LL58_OPIFE/2013-2094  AC A0A4S2LL58.1
#=GS A0A0R3U8T2_9CEST/122-202    AC A0A0R3U8T2.1
#=GS A0A0R3U9E4_9CEST/363-442    AC A0A0R3U9E4.1
#=GS A0A0R3TLY6_RODNA/735-809    AC A0A0R3TLY6.1
#=GS A0A4E0R999_FASHE/1832-1911  AC A0A4E0R999.1
#=GS A0A074Z4S6_9TREM/2282-2362  AC A0A074Z4S6.1
#=GS A0A068Y4K0_ECHMU/955-1036   AC A0A068Y4K0.1
#=GS A0A0R3X1M2_HYDTA/1050-1131  AC A0A0R3X1M2.1
#=GS A0A0R3UBA2_9CEST/154-232    AC A0A0R3UBA2.1
#=GS A0A4Z2D1K0_SCHJA/1353-1427  AC A0A4Z2D1K0.1
#=GS A0A0R3UD12_9CEST/103-171    AC A0A0R3UD12.1
#=GS A0A183MN70_9TREM/1217-1301  AC A0A183MN70.1
#=GS A0A3P8JXT4_TRIRE/608-675    AC A0A3P8JXT4.1
#=GS A0A654HFI8_9CEST/1424-1504  AC A0A654HFI8.1
#=GS A0A5J4NHS7_9TREM/1578-1659  AC A0A5J4NHS7.1
#=GS W6USZ0_ECHGR/1147-1228      AC W6USZ0.1
#=GS A0A4Z2D1S2_SCHJA/1389-1463  AC A0A4Z2D1S2.1
#=GS A0A182ZZD7_9TREM/651-730    AC A0A182ZZD7.1
#=GS A0A068Y1L2_ECHMU/1169-1250  AC A0A068Y1L2.1
#=GS A0A4V3SEF7_OPIFE/2012-2093  AC A0A4V3SEF7.1
#=GS A0A3P6N7T3_TAEAS/657-738    AC A0A3P6N7T3.1
#=GS W6U5N6_ECHGR/1048-1129      AC W6U5N6.1
#=GS A0A183SDI4_SCHSO/1780-1860  AC A0A183SDI4.1
#=GS A0A3Q0KLK2_SCHMA/1393-1468  AC A0A3Q0KLK2.1
#=GS A0A0R3UBT7_9CEST/250-330    AC A0A0R3UBT7.1
#=GS A0A6A5DAN5_SCHHA/1982-2057  AC A0A6A5DAN5.1
#=GS A0A504YFP1_FASGI/1832-1910  AC A0A504YFP1.1
#=GS A0A419PVP8_CLOSI/1994-2074  AC A0A419PVP8.1
#=GS A0A0S4MLS2_ECHMU/121-191    AC A0A0S4MLS2.1
#=GS A0A158REQ1_HYDTA/1140-1221  AC A0A158REQ1.1
#=GS A0A3P7WMK4_RODNA/964-1045   AC A0A3P7WMK4.1
#=GS A0A183KU67_9TREM/2-50       AC A0A183KU67.1
#=GS A0A0R3UDR8_9CEST/4-69       AC A0A0R3UDR8.1
#=GS A0A4Z2D2J8_SCHJA/1390-1464  AC A0A4Z2D2J8.1
#=GS A0A183P5D4_9TREM/1281-1355  AC A0A183P5D4.1
#=GS A0A3P7A5U0_HYMDI/807-888    AC A0A3P7A5U0.1
#=GS A0A4S2LMW4_OPIFE/2008-2089  AC A0A4S2LMW4.1
#=GS A0A0R3WAK7_TAEAS/1033-1114  AC A0A0R3WAK7.1
#=GS W6TZ96_ECHGR/224-288        AC W6TZ96.1
A0A3P7SY13_RODNA/844-925               ....edlg----VIRQKARKYPQLKALAFSLKSKLEKRSTS.........LHGANKENARLKVILGENEKRVQGFIQELERLRQQILVKNQVIKKLES-a...............
A0A5K4ELH8_SCHMA/1393-1468             .....tpn---------IRKYNELKVAAFEIKNKLISRTQK.........LEAALKEVERLRGVIQQDKERASGALDELKDLRQKVLRKNQRIRDLE--nd..............
A0A5K4EMI9_SCHMA/1393-1468             .....tpn---------IRKYNELKVAAFEIKNKLISRTQK.........LEAALKEVERLRGVIQQDKERASGALDELKDLRQKVLRKNQRIRDLE--nd..............
A0A0R3SIR5_HYMDI/878-959               .....edl---EAIRQKARKYPQLKALAFSLKAKLEKRSNS.........LHGTNKENARLKMIVGDNEKRVQGFIQELERLRQQILVKNKVIKKLES-v...............
A0A430Q675_SCHBO/1391-1460             .....psi----------HKYNELKFAAFEIKKQLISRTQK.........FGTALKEIERLRGVIQQDKERAGGVLEELKDLRQK----N---------qrirdlen........
A0A4S2LL58_OPIFE/2013-2094             .ttdqqsv-------ARSRKYGELKAVAFEIKEKLVHRTNK.........LESALTEVARLRSVIQQDKEHASRVLEEVEDLRKQAVRKNRMIRELET-e...............
A0A0R3U8T2_9CEST/122-202               .....sas----DMKEKARKYPELKAIVFKLKSRLRKRAEL.........LKSIMKENRCLRRIVHENERPAKGFLEKLERLRRRIVEKRGAIKKLEA-v...............
A0A0R3U9E4_9CEST/363-442               ......as----DMEEKARKYSELKAVAFKLKSRLHKRTEL.........LESSMKENRHLRRIAHENERRAKGFLEELERLRRQIVKKNAVIKKLM--av..............
A0A0R3TLY6_RODNA/735-809               .....tvg---EELVKRAKKYPELKVIANDLKLRLVKNAEL.........LEHSVAEAKRLRKIIHANDSKSNELLEELERLRAIILT-----------twfs............
A0A4E0R999_FASHE/1832-1911             ...velnq-------ARMRKYGELKAVAFEIKEKLVRRTEK.........LEVALTEVARLRSVIQQDKEHASRILEEVEDLRKQAIRKNKRIHELET-e...............
A0A074Z4S6_9TREM/2282-2362             .idpqsvi--------RSRKYGELKAVAFEIKEKLVHRTNK.........LESALTEVARLRSVIQQDKEHASRVLEEVEDLRKQAVRKNKMIRELET-e...............
A0A068Y4K0_ECHMU/955-1036              ......ai--SEELAEKAHKYPELKAIAMDLKSRLFKRAEL.........LEHSLNEAKRLRRIIQENDARAKEFLEELERLRMQILAKNSSFRQLERL................
A0A0R3X1M2_HYDTA/1050-1131             ......am--SEELAEKARKYPELKAIAMDLKSRLFKRAEL.........LEHSLNEAKRLRRIIQENDARAKEFLEELERLRTQILAKNSSIRHLEKL................
A0A0R3UBA2_9CEST/154-232               ......lg-----LEEKARNYPELSVAVLDLGSRLHKRAEL.........LESSTNEKRRLRRIVHEDERCAKVFLEELERLRRQMVEKNGAIKKLEV-v...............
A0A4Z2D1K0_SCHJA/1353-1427             .....psf----------RKYNELKAAAFEIRNKLISRTQK.........LETALKEIERLRGVIQQDKERANSTLEEVKELRQKVLRKNQRIRDLE--sd..............
A0A0R3UD12_9CEST/103-171               ..kstlel------EDNAREYSELKAVALELKSRLLKRAEL.........LENSLREARRLRGIVCDNKESAEGFGGELER------------------qypht...........
A0A183MN70_9TREM/1217-1301             .....tpn---------IRKYNELKFAAFEMKNKLISRTHYidcfclcrkLETALKEVERLRGVIQQDKERASGALEELKDLRQKVCLY----------mylcikslvl......
A0A3P8JXT4_TRIRE/608-675               ...annlr---------LRKYGELRTAAFEIKEKLIQRTEK.........LESALEEVARLRSVIQQDKERASITLKEVEDLREQV-------------gsv.............
A0A654HFI8_9CEST/1424-1504             .lsaeadr--------RVRKYPELRAIAIDLKEKLVRRTRR.........LETTLHEVRRLRAIIKEDETRAKNILGQMERLREQVLQKNHIIRQLEAL................
A0A5J4NHS7_9TREM/1578-1659             dmdlhsts--------RLHKYSELKAVAFEIKEKLIQRTNK.........LEAALTEVARLRSVIRQDKEHASHILEEVQDLRKQVIKDYIKTKPLA--ti..............
W6USZ0_ECHGR/1147-1228                 ........ELDETMREKARKYPELKAIAFDLKARLGKRAEL.........LESSMKETRRLKRIVMDNERRAKGFLEELERLRQQILMKNAMIKKLETL................
A0A4Z2D1S2_SCHJA/1389-1463             .....psf----------RKYNELKAAAFEIRNKLISRTQK.........LETALKEIERLRGVIQQDKERANSTLEEVKELRQKVLRKNQRIRDLE--sd..............
A0A182ZZD7_9TREM/651-730               ...velnq-------TRIRKYGELKAVAFEIKEKLVRRTDK.........LESALTEVARLRSVIQQDKEHASRILEEVEDLRKQAIRKNKRIHALEA-e...............
A0A068Y1L2_ECHMU/1169-1250             ........ELDETMREKARKYPELKAIAFDLKARLGKRAEL.........LESSMKETRRLKRIVMDNERRAKGFLEELERLRQQILMKNAMIKKLETL................
A0A4V3SEF7_OPIFE/2012-2093             .ttdqqsv-------ARSRKYGELKAVAFEIKEKLVHRTNK.........LESALTEVARLRSVIQQDKEHASRVLEEVEDLRKQAVRKNRMIRELET-e...............
A0A3P6N7T3_TAEAS/657-738               ........EMDETMREKARKYPELKAIAFDLKARLAKRAEL.........LEASTKETRRLKRIVMEDERRAKGFLEELERLRQQILVKNALIKKLEKL................
W6U5N6_ECHGR/1048-1129                 ......ai--SEELAEKARKYPELKAIAMDLKSRLFKRAEL.........LEHSLNEAKRLRRIIRENDARAKEFLEELERLRMQILAKNSSIRQLERL................
A0A183SDI4_SCHSO/1780-1860             .lsaeadr--------RVRQYPELRAIAIDLKEKLVRRTRR.........LETTLHEVRRLRAIIKEDETRAKNILSQTERLREQVLQKNHIIRQLEAL................
A0A3Q0KLK2_SCHMA/1393-1468             .....tpn---------IRKYNELKVAAFEIKNKLISRTQK.........LEAALKEVERLRGVIQQDKERASGALDELKDLRQKVLRKNQRIRDLE--nd..............
A0A0R3UBT7_9CEST/250-330               .....sas----EMEEKARKYPELKAIAFDLKSRLRKRAEL.........LESSMKENRRLRRIVHENERRAKGFLEELERLRRQIVEKKGAIKKLEA-v...............
A0A6A5DAN5_SCHHA/1982-2057             .....tps---------IRKYNELKCAAFEIKKQLISRTQK.........FGTALKEIERLRGVIQQDKERAGDVLEELKDLRQKVLRKNQRIRDLE--nd..............
A0A504YFP1_FASGI/1832-1910             ...elnea--------RMRKYGELKAVAFEIKEKLVRRTEK.........LEVALTEVARLRSVIQQDKEHASRILEEVEDLRKQAIRKNKRIHELET-e...............
A0A419PVP8_CLOSI/1994-2074             .tdpqsva--------RSRKYGELKAVAFEIKEKLVHRTNK.........LESALTEVARLRSVIQQDKEHASRVLEEVEDLRKQAVRKNRMIRELET-e...............
A0A0S4MLS2_ECHMU/121-191               .......r-IDETMQGKACKYPELKSIAFGRRTRFAKRAQL.........QASSMKEARGLKSIVMKNERHD---------------------------svtvgaalnhirridf
A0A158REQ1_HYDTA/1140-1221             ........EMDEIMREKARKYPELKAIAFDLKARLAKRAEL.........LEASTKETKRLKRIVMDDERRAKGFLEELERLRQQILVKNALIKKLEKL................
A0A3P7WMK4_RODNA/964-1045              .....edl---EGIRQKARKYPELKSLAFTFKNKADRSAAL.........LHDFTKENTRLKMIVSDHEKRVKELANELERLREQILVKNEVIKKLENL................
A0A183KU67_9TREM/2-50                  ......fg---------------------------------.........--TALKEIERLRGVIQQDKERAGGVLEELKDLRQKVLRKNQRIRDLE--nd..............
A0A0R3UDR8_9CEST/4-69                  ...tvese-------DNAREYSELKAVALELKSRLLKRAEL.........LENSLREARRLRGIVCDNKESAEGFGGELER------------------qyph............
A0A4Z2D2J8_SCHJA/1390-1464             .....psf----------RKYNELKAAAFEIRNKLISRTQK.........LETALKEIERLRGVIQQDKERANSTLEEVKELRQKVLRKNQRIRDLE--sd..............
A0A183P5D4_9TREM/1281-1355             .....tps---------IRKYNELKCAAFEIKKQLISRTQK.........FGTALKEIERLRGVIQQDKERAGGVLEELKDLRQKVCLY----------mylcikslv.......
A0A3P7A5U0_HYMDI/807-888               .......a-VDEELVKRARKYPELKAIANDLKQRLVKRAEL.........LEHSVAEAKRLRKIIHANDSKSNELLEELERLRAIIVVKNSKIQQLESL................
A0A4S2LMW4_OPIFE/2008-2089             .ttdqqsv-------ARSRKYGELKAVAFEIKEKLVHRTNK.........LESALTEVARLRSVIQQDKEHASRVLEEVEDLRKQAVRKNRMIRELET-e...............
A0A0R3WAK7_TAEAS/1033-1114             ......ai--SEELAEKARKYPELKAIAMDLKSRLFKRAEL.........LEHSLNEAKRLRRIIQENDERAKEFLEELERLRAQILAKNSSIRQLEKL................
W6TZ96_ECHGR/224-288                   .......r-IDETMPEKARKYPELKSIAFGLRARFAKRAEL.........QASSMKEARGLKSIVMKNERRVRRFAEELERI-----------------................
#=GC seq_cons                          ......sh........+sRKYsELKAlAF-lKp+Lh+Rsph.........LEsuL+EscRLRulIppcccRApthLEELEcLRpplltKNthI+cLE..................
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