GenomeNet

Database: Pfam
Entry: DUF5984
LinkDB: DUF5984
Original site: DUF5984 
#=GF ID   DUF5984
#=GF AC   PF19446.2
#=GF DE   Family of unknown function (DUF5984)
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   23.80 23.80;
#=GF TC   26.40 25.90;
#=GF NC   23.40 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC).  This BGC (BGC0000838) is described by MIBiG as an
#=GF CC   example of the following biosynthetic class, polyketide, in
#=GF CC   particular the flexirubin biosynthetic gene cluster from
#=GF CC   Flavobacterium johnsoniae. This protein has no known function. 
#=GF CC   It is found in Actinobacteria, Proteobacteria and Bacteroidetes.
#=GF CC   Proteins in this family are typically between 234 and 271 amino
#=GF CC   acids in length.
#=GF SQ   58
#=GS A0A3N1AVC5_9ACTN/15-258  AC A0A3N1AVC5.1
#=GS A0A3E0I062_9PSEU/74-165  AC A0A3E0I062.1
#=GS A0A285LQY0_9NOCA/3-248   AC A0A285LQY0.1
#=GS F4F8C2_MICM1/3-253       AC F4F8C2.1
#=GS A0A6B2TWL0_9ACTN/1-58    AC A0A6B2TWL0.1
#=GS U2QT52_9FUSO/79-204      AC U2QT52.1
#=GS C7PPG9_CHIPD/3-258       AC C7PPG9.1
#=GS F0EWR4_9NEIS/3-263       AC F0EWR4.1
#=GS A0A318SIN0_9DEIO/4-256   AC A0A318SIN0.1
#=GS D7CB07_STRBB/3-250       AC D7CB07.1
#=GS A0A495XMF6_9PSEU/10-207  AC A0A495XMF6.1
#=GS A0A1I2JIZ8_9ACTN/1-134   AC A0A1I2JIZ8.1
#=GS A0A1C5IV05_9ACTN/3-253   AC A0A1C5IV05.1
#=GS A0A1A9S2F6_9NEIS/3-276   AC A0A1A9S2F6.1
#=GS A0A4R4YN86_9ACTN/2-222   AC A0A4R4YN86.1
#=GS A0A7C9HSL7_9DEIO/4-257   AC A0A7C9HSL7.1
#=GS A0A2U0ZS05_9BACT/3-262   AC A0A2U0ZS05.1
#=GS A0A562ZV23_9BURK/1-228   AC A0A562ZV23.1
#=GS A0A0M3QCS8_SPHS1/2-251   AC A0A0M3QCS8.1
#=GS A0A5D0CKH6_9BACL/1-256   AC A0A5D0CKH6.1
#=GS A0A173MBR6_9BACT/3-262   AC A0A173MBR6.1
#=GS A0A0K1Q2V8_9DELT/1-107   AC A0A0K1Q2V8.1
#=GS A0A3N1ASH0_9ACTN/12-107  AC A0A3N1ASH0.1
#=GS A0A4Y8Q7D2_9BACL/1-255   AC A0A4Y8Q7D2.1
#=GS K0ESN9_9NOCA/3-248       AC K0ESN9.1
#=GS A0A543CIC9_9ACTN/4-245   AC A0A543CIC9.1
#=GS A0A5M3XE22_9ACTN/1-183   AC A0A5M3XE22.1
#=GS A0A561B389_9ACTN/3-229   AC A0A561B389.1
#=GS I0W5K9_9FLAO/1-253       AC I0W5K9.1
#=GS A0A1K1R7B8_9BACT/3-260   AC A0A1K1R7B8.1
#=GS A0A239PCM7_9ACTN/3-249   AC A0A239PCM7.1
#=GS A0A1I0MNI2_9FIRM/3-256   AC A0A1I0MNI2.1
#=GS A0A1C4Q3C6_9ACTN/8-250   AC A0A1C4Q3C6.1
#=GS A0A285K2W8_9ACTN/3-232   AC A0A285K2W8.1
#=GS A0A2R7T094_9BURK/5-256   AC A0A2R7T094.1
#=GS B4D7D5_9BACT/22-269      AC B4D7D5.1
#=GS A0A4Y9T289_9BURK/2-251   AC A0A4Y9T289.1
#=GS A0A0X3V975_9ACTN/3-240   AC A0A0X3V975.1
#=GS A0A1Q4XJ19_9ACTN/2-247   AC A0A1Q4XJ19.1
#=GS A0A402CQY7_9BACT/2-261   AC A0A402CQY7.1
#=GS A0A2K9E409_9FIRM/42-220  AC A0A2K9E409.1
#=GS V6KK51_STRNV/3-224       AC V6KK51.1
#=GS B8HYN2_CYAP4/2-260       AC B8HYN2.1
#=GS A0A0Q8P3P5_9ACTN/3-237   AC A0A0Q8P3P5.1
#=GS A0A495JRD0_9ACTN/3-241   AC A0A495JRD0.1
#=GS A0A1T3P8N9_9ACTN/2-247   AC A0A1T3P8N9.1
#=GS F7NHZ2_9FIRM/43-207      AC F7NHZ2.1
#=GS A0A0D8I0N3_RHOSX/1-182   AC A0A0D8I0N3.1
#=GS A0A0M9YCD0_9ACTN/1-238   AC A0A0M9YCD0.1
#=GS A0A518EZY8_9BACT/2-247   AC A0A518EZY8.1
#=GS A0A3E0I062_9PSEU/2-78    AC A0A3E0I062.1
#=GS F0EWQ9_9NEIS/23-296      AC F0EWQ9.1
#=GS D1AI99_SEBTE/1-218       AC D1AI99.1
#=GS G0J4U1_CYCMS/1-257       AC G0J4U1.1
#=GS A0A402BBP2_9CHLR/2-267   AC A0A402BBP2.1
#=GS A0A429W8T2_9BURK/2-250   AC A0A429W8T2.1
#=GS U5W8B7_9ACTN/3-207       AC U5W8B7.1
#=GS A0A6B2TW14_9ACTN/1-155   AC A0A6B2TW14.1
A0A3N1AVC5_9ACTN/15-258             ....................................................RFQFQLRPLDQVHP.WG..RD...KQ...TLHWFGLTEGWYWLDLTGHQLLRY.......SAETVRRRQADgHDDP....PYADYYIARLWEDLLQLLPTILEPVPADLLPFIE..........ADATTWT-----TRDNE--SDADT................TAEEWYGDH..................YL..DFGYL.RNAPNVRCWRTi.....stDDTVTIDWWNQRPDPNDD...IIFTGPARGRTAFCTQQLTDAVRDLDHQLMAAMDKRVSELE...............GRG.SPPGVELDLVALRNEHRERMTWLTHAL.....DRTPATDWAATRAG............................
A0A3E0I062_9PSEU/74-165             ....................................................--------------.--..--...--...------------------------.......-----------.----....----------------------------------..........------------------------................--------H..................NF..NLGYI.RGAPSLRLHRI........HNRVKIWW-----REDG-...------TDVVTAVPLKEFLAALAEFDQEVMAAMVERLG---...............---.-------DDPRLLAEHADRSRWLGR--.....--------------ivggqsraqcs.................
A0A285LQY0_9NOCA/3-248              ....................................................RVRFELAPLEEVVP.WG..-E...HR...RLHWFGLTQGWYCLEVGGVELLRY.......AERPRNSTGDGgAAVT....SWVDYYVVRLWEDLLAVLPSALEPVPEDLAKFFA..........AGAEGWVDTGDL--ALLDDPAIE-................AASEAYGLR..................WT..DTSYL.RFGPAFRWWRTl.....gpEDTITMAW-QFTSDPDGE...ITFSAPPSGVRTVGTEEFIAAVADFDHRLLQAMQERVDHLA...............AAG.GIREIELDIPALIREQAQRQTWLPRAL.....ARQDDTDWAAVRAG............................
F4F8C2_MICM1/3-253                  ....................................................RFRFELYPLDEVSP.WG..RD...QP...SLHWFGLTEGWYWLETSGQELLR-.......-----RTRQSD.--PH....PYIDYYLARLWEDLIVLTPEVLEPVPDDLQPFIA..........SHHAQWT-----CDPLEFVEEPDErrfddgnadvpdhpvvTAAVWHGEH..................HL..DFGYL.RNPPTLRLWRTtc....gdRDEITLDW---RHEDDGE...IGFTADSTVRLSLPTTAYLEAVHILDRELMDAMGQRVEDLE...............HRG.GLPGVDIDLVDLRREHEDRRHWLARNL.....DRAPKTDWNAVRQG............................
A0A6B2TWL0_9ACTN/1-58               ....................................................--------------.--..--...--...------------------------.......-----------.----....----------------------------------..........------------------------................---------..................--..-MGHL.CIAPTILCWRQ........ADEVTIRW--QLKDPEP-...SFFAGRRTGKVTVGRPEFVAAVEELDQ--------------...............---.---------------------------.....--------------a...........................
U2QT52_9FUSO/79-204                 ....................................ieirkkayaigikenk--------------.--..--...--...------------------------.......-----------.----....----------------------------------..........------------------EIEWFE................AVYEWSERH..................LW..TFSGLeMIYPDVMFRRI........ENKIEISWDSKNKYTDNKnykIEFTH-PKGSFFVNMEKFEKEVLSFIDR-------------...............---.---------------------------.....--------------veriteiiskkmksvfngkyidssylyk
C7PPG9_CHIPD/3-258                  ...................................................f-INFKLRHPDNIIP.WG..-D...QPd.tIMDWTALTDGEYWLDVNKTTLYEY.......TNEVLAGGNGN.--DS....TYVEYQLVRLIEDWTGLFESIAESVPDAFYAISKdnsy.lyrfyTAVTKWIDNAAEDASIDVD--TYE................KTIEWIYSR..................TL..NAMHL.TGGPGISFFRN........GNNISIVWKADHLTENN-...IPVWTAQNGAVEMEYKAFVNEMEDFGHRFFDAMDTQVGIAV...............EKD.-WGTTRLNKEQLVQEHQERRAEFQKSLvvlkgEPTKHTDWDLINS-l...........................
F0EWR4_9NEIS/3-263                  ....................................................LFDFTLRNTTQTLA.AN..--...--...SPCWYWLTDGSYNICINGKRLLSYnpaistaNERAQWKQQAAaGGLHa.yeP--EYYVVRLYEDVLA------EALP--------..........---YTWNNVSEMQHQCLLNPTVYR................MVSEECDDRllfhedkslydkchpycgQF..GSGYM.ML-PEFRLWRY........ADEIYIYWNGNGKNPHGI...SWFQHTGEAVFVMDAGAFLREVEDFHHRLMNAMAEHIGQVQdy..........cirHPD.IPAAVIFDYAFVAADHERRRQSLDKALrr.kqSANPDFERDNLNAG............................
A0A318SIN0_9DEIO/4-256              ...................................................t-FRHRLRPLPDLLA.LW..KEggvDPrsyLTGWFWLTDGRYAIDTPHGRVFAY.......HPAFVTAHDVV.GEDA....HFLDDQVGRLWWNLAEILPDVLDVLPTPFDAWVEtgqw..qawlASVTEWWNGLDEHESDLTWNAWY-................EATAWWGAR..................HL..DTGYL.AAGPRVVLWRV........RTTVTMEWDARRRLVDG-...VPCWEETAGRVTLSVTEFQAEVEAFRVRLHAEMERRLREVA...............ALG.--MLTRAEEADLRRQHADSFARV----.....GRSDGTNWTTVLA-a...........................
D7CB07_STRBB/3-250                  ....................................................RFRFGLTPLAEVRP.WG.rRE...RP...VLHWFGLTDGWYAIDLGEHELLRY.......SERTVRRLRGDgGGPA...hPYADYYVVRLWEDLLALLPAALEPVPEDLADFVA..........CDSSDWC-----WED---TPEAD-................SAAQWHGDR..................SL..YTGYL.RIAPDIRCWRTvagehdamDDVMNVSW-AHPSDPEGE...IEFAGPATGRVTVPTSAFVAAVTELDRALLEAMERRIGELE...............AAG.PPPGVELDLEQLRREHRDRAGWLERAR.....RYAYATDWAAVRTG............................
A0A495XMF6_9PSEU/10-207             ....................................................RIDFSLTPLDQVER.WG..--...GN...QLHWFALTDGVYRLRFGDHAFPD-.......----------D.----....-EVDYYLARVWEDLLVLAPAALEPVPADLVDLVR..........GEVVIND--------EDL------................AALHWYSDH..................YL..DFGYV.QGVRGCQWWRL........DDVLHVEW------P---...-------GHHVTMPVEAFTAALTGFHHALMAAMEQRVRHCE...............TQG.VPPGTGLDVAGLRREHEDRKTWLAPAL.....-RPRTTDLAAVRR-a...........................
A0A1I2JIZ8_9ACTN/1-134              ..................................................mf--------------.--..--...--...------------------------.......-----------.----....----YYVVRLREDVIALVSETMELVPEDLVDAVA..........ASPDRAW---------LDTPEAD-................AASTWYNAG..................YL..STGYL.RVAPSIRFWRTvv....ggADTVTVAW-EHEPDPEGL...IEFVGPSAGQVAMPTNEFLAAVTELDRALLAAMDQRISEL-...............---.---------------------------.....--------------............................
A0A1C5IV05_9ACTN/3-253              ....................................................RFRFELYPLDEVSS.WG..GD...EP...TLHWFGLTEGWYWLEVGGHQLLR-.......-----RTRLDH.--PH....PYVDYYLARLWEDVNVLTPDVLEPVPADLQLFIA..........SDPAQWA-----CDPLAFVTAGDEdrfgdidpnvpdhpvvTAANWHGEH..................YL..DLGYL.RNAPSLRFWRTvr....gdRDGITVDW---RHEDNGE...IGFTAGQAVRFCVPTAAYLEAVHTLDRGLMTAMLQRVEELE...............RRG.GLPGVDLDLAGLRREHEDRGHWLAKNL.....NRTPKTDWDAVRQG............................
A0A1A9S2F6_9NEIS/3-276              ....................................................LFDFTLKNIKQTLE.FN..--...HS...SPCWFWLTDGSYNICINGKRLLSYhpdsftaAEQAQLKQQARkNGLP...fCEPDYYIVRLYEDLLH------DALP--------..........---YTWHNVSEIEHQCLLNPAAHR................LADKKHWDNpildediellekcmfrygNF..GSGHM.LM-PEFRVWRY........ADEIYIYWNGKHKNEHGI...SYFQHTGEAVFVISHHDFMREAHDFHHRLMNAMAERIHQIQtgfpdfypvvqdiadKDGtPMGETTYDLAGLLAEHREREREWEQALqn.knAGNPNFEQDNLRAG............................
A0A4R4YN86_9ACTN/2-222              ....................................................RFRFGFHPLAEVGL.WG..GD...KP...TLHWFGLTDGWYWIELGDVRLLKF.......AADY-------.--DI....PYVDYYVVRLWEDLLALLPAALEDVPTDLLGFLE..........SDGRDWCDV---------ESEAAD................AAIDCWSDR..................SL..NFSYL.RESPSLRCWRT........GNDLTIDW----NAPT--...-NFAEPRTLRTTVTVADFVTAVDELHATLMAAMEARAIEVE...............ASP.-RAGVDLDLPNLHREHQDRAQWLTRAR.....SRIRTTDWTAVRTG............................
A0A7C9HSL7_9DEIO/4-257              ....................................................LFGFRLRPLPELLErWTagGA...DPlpyLRGWYWLTDGWYWLRTPAGDVPTN.......HPEFDYALGQP.PGPE....PHLDYLVARFWLDLEGLLPRVLEPLPAELAAALAsgaw..dawhAPVSAWWHALPDDDE-QASWELWS................AATSWANVR..................AL..DMGYL.AAPPLLRFWRV........GENVNVAWDTREQRVQG-...HLCWTETWGQQAMSVAAFAAEVEDFRGRLDTAMTARVQAVA...............ALG.-----QLDAAALTSLAQQRQLTLFPES.....GLQDPTDWGAVLS-a...........................
A0A2U0ZS05_9BACT/3-262              ....................................................LINFKLKHPDNIAP.WG..-D...TPd.tNMHWFGLTDGEYWLDVNKATLYEY.......AKEVLTGGNVNhT---....HYVDYQIFRLLEDWTNMFESIAEPVPDAFYAIARtndy.lyrfyEAAQNWFENLSKDPSIDADAHYDSy..............dKAIEWIYSR..................TL..SSSHL.NFEPGISFFRN........RNNISIVWKADHVTENN-...IPVWTAQNGEIEMEYAMFVNEIEDFGNRFFTAMDTQVQIAV...............EKD.-WGATVLNKEQLIKEQRDRKAWFQQRLsalkdAPTKHTDWNVINS-l...........................
A0A562ZV23_9BURK/1-228              ....................................................--------------.--..--...--...-MSWFGLTDGQYWLEAGSSVLFEY.......SKYARSHGSKQ.----....-YCDYQVVRLYEDLTDMLPSILEPVPTSLVQYISgeta..iswqRTFEQWREEYGDRTSEDRFWEVVS................AATEWQSKR..................HL..DSLYL.SPSANIAIWSD........VESVHLEWDNREKQIDG-...QPAWTALKGAYKLPRSDFAREVESFHTRLMDQMEERVHRVS...............AGA.LSAEIDVDLAALAREHEQRRQSLRVAS.....DVRPETDWLKVE--rt..........................
A0A0M3QCS8_SPHS1/2-251              ....................................................LIDFELTPIKEVVP.WG.tPG...NH...SLTWFGLTEGRYWINAGVATLFEY.......SDRVRHSDGSR.----....-YCDYYVARIFEDVMNMLPTILEAVPQDLRAYVSgnsg..rewiKACESWSEKNLDEGAEDETWDTWE................RANLLLRDR..................FL..ETGYL.SPSTSIVMWSD........ETDVHIEWGNRDKFIDG-...GLAWSAVSGSFHLPREKFVMEVEAFHARLFERMTSRIEQVA...............AGA.LHPDVQIDLPGLIAENERRQGMFAQAL.....GQKGATPWDEIRS-a...........................
A0A5D0CKH6_9BACL/1-256              ....................................................MIQYQLKDWKEIVP.WQ.nGN...CS...TLHWFALTDAHYWFNFKGVEFPKY.......SDEIIREWKPE.ND-S....KFVDYPFARIFWDICEVIRHVENSVPNEIFQKINsldk.lkkyiELLKNWIELAWDESDEQFDEVYE-................VARGWLYCR..................RL..DFGYL.TGGPDCFLIRN........EDQLHIYWFAEYQNDKG-...ISLWSSHEGTFSCNYFEFIEDLVKSFKAFGLDMNKQISALL...............ESN.-PTDLEIDSEQILTNQSQYEELV----.....--------------safenkkllyadtpdwkhivn.......
A0A173MBR6_9BACT/3-262              ....................................................LINFKLKHPANIIP.WG.dAP...DT...SMDWFGLTDGEYWLDVNKATLYEY.......TREVLSGNHVNdS---....CYVDYPIARLLEDWTSIFESIAEPVPDAFYTIAQsnny.lyrfyEAAQNWFDNLSQDPSIDANAHYDSy..............dKAIEWIYSR..................TL..TAMHL.TSGPGISFFRN........RNNISIVWKADHLTENN-...IPVWTAQDGEVAMEYATFIHEIEDFGHRFFTAMDAQVQIAV...............EKN.-WGTTQVNKERLIQEQQERRAGFQQKLsilngQPTKHTEWNVINS-m...........................
A0A0K1Q2V8_9DELT/1-107              ...................................................m--------------.--..--...--...------------------------.......-----------.----....----------------------------------..........------------------------................---------..................--..-----.---------RI........GDQIRVHWDTEDRQIDG-...IPVWTATRGTFALSVEAFVDECRSFRDRLLHRMAARIDEVE...............AGR.AKPQADIDVASLRQQHATWEREFSDYTd...gTHHPDVAWEEAES-a...........................
A0A3N1ASH0_9ACTN/12-107             ................................................reap--------------.--..--...--...------------------------.......-----------.----....----------------------------------..........------------------------................---------..................--..-----.-----------........-----------QPDPNDD...IIFTGPARGRTAFCTQQLTDAVRDLDHQLMAAMDKRVSELE...............GRG.SPPGVELDLVALRNEHRERMTWLTHAL.....DRTPATDWAATRAG............................
A0A4Y8Q7D2_9BACL/1-255              ....................................................MFKFLLKGLEEITP.WG.eGN...QR...YLHWFGLTDAWYWLDIEGVQLLRY.......SDEFLQKYLSQ.---L....PYVDYQLARLFWDFTGIVRDVLAPIPDEVFANIRtfen.feaylDTLADWLEH-EWDGTEEVYDRIYV................PASQWVAQR..................RL..DSSYL.IGAPRIYFFRN........GEQFYVRWIADFVDEQG-...VPMWQTAKGEYVVDFGTFVAGLQQSVRAFAGAMDKQVKLAL...............-DV.PSDLIYIDRAKLLGNHEEFLREVEA--.....--------------yddilsfvsdwadwedvaak........
K0ESN9_9NOCA/3-248                  ....................................................RFRFGLAPVDRVAP.WG..EQ...RR...TLRWFALTEGWYGIDLGGQTLLRY.......SARTTELLRTQsGGAEtpydCYVAYYVARLWEDLLALLPSVLEPVPEDLADFIG..........ADAADWS-----WAE---SDEAD-................AAATWYGEH..................TL..DTGYL.WFGPHLRWWRTvd....gaADTVTLAW-HHPPDPEHE...IEFAAPSSGRIRVSTDEFRSAVIELDRALLSAMATRLREFE...............SSG.PPPGIDLDLDHLAYEQDDRARWLARAM.....NQRPDTDWSAIRSG............................
A0A543CIC9_9ACTN/4-245              ....................................................RFRFALTPMDRVQP.WG.wEE...DP...HLHWFGLTDGWYWIELGDQELLRY.......SPETLEWFGRDdLGLR...hPYADYQVVRLWEDLIDLTPMVMQPVPNDLEPFIS..........ADVPERP---DLDDD----EDAW-................SAMVWCSEH..................YL..DPGYL.RAAPEVCAWRSl.....agDDTVTVAW---QHPRDDE...IVFTAPQAGQVTVPTEAYLTAVRRLDTELMAAMHDRITELE...............LVG.PPQGVRIDMDQLRAEHHGRTTWLSEHL.....RFQPTTDWAAVRSG............................
A0A5M3XE22_9ACTN/1-183              ...................................................m--------------.--..--...--...------------------------.......-----------.--QH....PYVGYYVARLWEDINAMTPTVLEPVPSDLLDFVG..........SDPSAWR-------PV--ESDAAS................VAAVWHNEH..................AL..DLGYI.LQPPRIRAWRTvs....ddLDTVTVTW---QHADDGD...IRFVADPAGQVIVPAASFRTAVRQLDHELLISMERRIRVLE...............RTG.PPDGVQFDLQAVRAEHANRGESLAQWL.....HREPATDWAVVRV-g...........................
A0A561B389_9ACTN/3-229              ....................................................RFRFGLRPLAEIAP.WG..GD...RP...NLSWFGLTDGWYWIELGDVDLLRH.......----LPEDG--.-DEH....PAVDYYVARFWEDLLRLFPAVIEDVPAALVDLLR..........SDPRTWP---ELDPD---DPVTD-................SVLTWSTDH..................FL..DVGYL.GNAPTIRCWRH........GDQVTIGW--Q---DSDP...SRYTAPPSGEVTVSLSEFLAAVGDLHQALITAMETRVAEVI...............AAP.-PPHVAIDLTQLRAEQADRATWLSHAT.....ARQPATNWSHIH--ta..........................
I0W5K9_9FLAO/1-253                  ....................................................MIHFKLKDIDSVIP.IG..--...-N...DLNWFSLTDGELYLNVENYKLFEY.......TSQAMQYFDDK.--TS....PYIDYYIARFLEDFTQLFMAIGESIPDHLYELTKnlh....yfqENTSKWLSILDKDDDMPSNFYFEEy..............tSVCSWINNR..................QL..NSSHL.IGGPSVYFLRN........RDKIRIAWETDQTLDNS-...IKLWTAKTDSLEMDYIEFVNHVKSFGMGFFKEMTQQVDKAL...............YKD.-WGQINLDKQKLIQEQIDRELAFQRSIsllieVKDCQTNWDEIDD-l...........................
A0A1K1R7B8_9BACT/3-260              ....................................................LINFRLKHPDLIVP.WG.dAP...DT...SMDWFGLTEGEYWLDLKKATLYEY.......TDEILRGDHDT.-R--....-YVEFQIARLIEDWTGIFASIAEAVPDGFYSIANscsy.lyrfyGAVQQLQDRLTADAAEDVQAKYDRy..............dKAIDWIYNR..................TL..LAPHL.TCAPGLSFFRN........GDKLALVWKADHRVESN-...IPVWTAKNGEIELPYEVFVREMEEFGERFFSAMDEQVQLAV...............EKD.-WGNTKINSARLVKEQQERRAAFQKKVavlkeEVMNPTDWKLVNA-v...........................
A0A239PCM7_9ACTN/3-249              ....................................................RFRFELYALDEVSP.WG..SE...QP...RLHWFGLTEGWYWLEASGHELLR-.......-----RARQGH.--PH....PYIDYYLARLWEDVLVLTPKVLEPVPGDLRPFIA..........SHGTQWT-----CDPLEFVEEPDEqstddv....pdhpvvTAAIWHAEH..................YL..DFGYL.RNPPKLRFWRTtg....ddRDEITVDW---RHEDDDE...IGFTADPAVRLSVPTTAYLEAVHTLDRELMAAMTQRVEELE...............HRG.GLAGVDLDLVAVRREHEDRRQWLAKNL.....DRSPKTDWDAVRQG............................
A0A1I0MNI2_9FIRM/3-256              ....................................................RINFLLKKPSEITP.WG..EL...HP...TLHWFGLTDGLLWIEIGDSVIYEY.......AETHTDEKGNL.---I....KYNDYQLSRFLEDFSEILPYVSEPIPRSLYYAVEs.......feKDTDAWKDLYADDDDETFDEFYFGd.............yeTLTSWFFDR..................CL..DSGHL.IDGPLIGCFRC........GDRIKIRWDSIRSESDNR...SSIWKYPSGCVEISYSEFVSEVLRFFSTFHDEMDKQVEDVV...............CNG.-IPGVEVDTNALIRENRSRKDGFSQKTdhltsDKESATDWKDITD-l...........................
A0A1C4Q3C6_9ACTN/8-250              ...................................................g-FRFGLTPLERVTP.WG..GE...HP...VLHWFALTDGWYCIDLDGHEVLRY.......SERTVQALRSDpEAGPp..hPYVDYYVVRLWEDVIALVSEAMEPVPEDVADAVE..........VLPDSA---------WPETPEAE-................AASTWHSAG..................YL..NTSYL.RVAPRIRCWRSvv....gdADAVTVAW-EQQVDPEGV...IEFAGPPAGRVVMPTGEFLAAVTELDRSLLAAMDQRISDLE...............HTN.VVPRVDVDIGQLRREHLDRATWLQRAR.....NHDPGTDWDAVREG............................
A0A285K2W8_9ACTN/3-232              ....................................................RFRFELYPLDEVSP.WG..GE...QP...ALHWFGLTEGWYWIEVGGHELLR-.......-----RARADY.--HP....PYVDYYLARLWEDVNMLTPQVLEVVPSELEPFIA..........SEQEGEF-----EDDSD-----EE................AAAFWHCEH..................YL..DFGYI.RNAPRVRLWRTvn....gdRDEVTLDW---RHHDDGD...IGFTAGPAVRVSVPTADYLEAVRALDRELMAAMRKRIQEIE...............RRG.GLPGVEIDLAGLEREHEDRTRWLRLNL.....ARSIETDWAAITR-g...........................
A0A2R7T094_9BURK/5-256              ....................................................LFQFELRPLDHIQP.WG.ePE...DP...NLHWFGLTDGLYWIQAGGHRLFEY.......SNIAQAR----.SGVP....PFCDYQVVRLYEDVIDLAPHALEPVPEELQRYIAldes..kpwnYYWSKWCEAVDTSGASEDSMNILD................EAGHWMGRR..................TL..DSAYL.APSTNIVFWSN........QESVQIQWDNRDKLLQD-...CQAWSAQVGSWRLPRVKFMDEVRSFHERLMEQMEKRVSQVA...............AGA.LAKTVRVDLGGLRREQQTRSQSIERNL....gQPALPTDWPSVVA-a...........................
B4D7D5_9BACT/22-269                 ....................................................LFEFDLDPVEEIVP.WG.sPN...DP...SLSWFVLTLGQFRMPIGDQVLFRY.......REEVLRLWESDvQR--....-DAHYQIASIARDILGSVAPGVAPLPPFFELLATdr.....allEQLLSVR--LEDEAGRELSPDYY-................TAWRWLGER..................SP..WTGYF.VENPEFYFVRI........GDRIHIRWDNRSKRVDG-...TEVWEASYGSYEIPIEAFTSECRDFSDRLLADMHKRISCIE...............TGD.FHPQVAVSIDSLREQQESWRCEFDSYF....rAERQDIPWEEAE--se..........................
A0A4Y9T289_9BURK/2-251              ....................................................LINFELTPLKHVMP.WG..EP...NN..lSLSWFGLTDGQYWISVGETSLFEY.......SEHARSAGAGR.----....-YCEYQVVRLLEDILDMLPSIMEPIPPTLVRYLSgdsg..kawqAKLSSWASEQYDAIDEDEYWRLAD................LAGSLSYNR..................FL..DSAYL.SPSATILIWSD........EKDVHIEWDNSEKFIDE-...KVAWTARKGHFHMPREVFIREVESFHFRLIEQMTSRVSQVV...............AGA.LPPDIRIDFKGLLSEHEQRRNAFSLAL.....RNTISTSWGEVEQ-a...........................
A0A0X3V975_9ACTN/3-240              ....................................................RIEFVLRPVLDVPA.WG..GD...EP...RLHWFGLTSAWYWMSAPGCEFLRY.......TDDAVRHWDLE.-R--....PHPDYYVARLWEDLNGLRWALREPVPEDLIPLVD..........GTFVSRE-----FPDDDFGDDVD-................AVFDVQGDY..................CL..DLGYL.TDSPEVSCWRHvv....dgADLVTF---RQQVAPAG-...LGTFGPAQLDATVPAVEFFAAVEDFDRRFIAAMEDRVTALE...............RSG.PPPGIDLDVRQLRAEHTNRSGWLGQRL.....TTPRAVDWAKVRV-g...........................
A0A1Q4XJ19_9ACTN/2-247              ....................................................RFRFELRALADVGP.WG.gEH...HR...TLHWFGLTQGWYWIEAGGQELLRY.......SERTLRPWREE.SGGEv..rPYADYYVVRIWEDVLAILADALEPVPADLVPFVS..........GELSGHP----LWDEEDLTPEAE-................AAAEWHGHR..................SM..YMGPL.VNAPQLRWWRTvd....eaGDRITLSW---AHEPGHR...IGFAASPAGRLVLPTDDFLAAVAELDGALLAAMEQRVATLE...............ASG.PPAGVELDLEQLRREHRDRAGWLERAR.....TRTCATDWAAVRAG............................
A0A402CQY7_9BACT/2-261              ....................................................LFNFRLKPTDKIAP.WS.tPS...RNnslSLHWFGLTDGWFWIDIGGQQPFRY.......SQEILNHWAQEpQA-TisplPFDDYQVTRYWEDLLELVPSILDPLPSDLATRVSdada.wgqwrERAAEWRETSE---D-ETSWETYE................TALQWWFSR..................TW..SNGHL.RIPPKIWLWST........DDQVHIRWDCRDILQDG-...VLVWDAKHGEVAMPKRDFIHEVQSFGARLIDTMATRVDEIK...............KHW.ARPEIAIDIHSLEQEQDYRATICENAL....gRIHRDYEWDDVRA-a...........................
A0A2K9E409_9FIRM/42-220             ..................grldlwvsgknlcqykvgdtvnvyiwnlfyview--------------.--..--...--...------------------------.......-----------.----....---------FCENLHHILGYDPFPLPVKGENTLEl........iQ----KADTFDI-DEEDENYLWHH................AKRTWIFRH..................TWfpNRGGS.RL-PSVYFRRV........GENIEIAWNNNFY-ENKS...IEFVHS-KGVGVIPKKEFKGVVFAFLNNILDELDLKISERF...............QED.KKQL-----------------------.....--------------ielrekl.....................
V6KK51_STRNV/3-224                  ....................................................RIRFGLTPVHDIQP.WG..GD...TP...SLSWFSLTDGWYDIEADGRHLFRH.......PADG-------.----....TSVDYYVVRLWEDVLDALPQALEPVPADLVAFMA..........GGHTRWL-----PAD---RPDTE-................AAATWYGQH..................TL..DTGYS.RAASHIRWWRTva...eagDDLMTVTW-TEAQDVDD-...--------GRVTLPTPDFVAAVTALHHDLLAAMEERVTALE...............ATG.PPSGVHIDLPHLRHEQRDRATWLGRAL.....ERACDTDWAAVRAG............................
B8HYN2_CYAP4/2-260                  ....................................................LFDFYLRPLEEIQP.WG.nPD...QL...NLHWFGLTDGCYRLQVGTECLLNY.......SDAFIDDRKKQfPDAYg..gPYTDYYVVRLWEDLLNILPNILEPLPAELARIFApdltawfnwfDAAVNWDEHQSAPEEPPEEQDPFE................LLVGWQQAR..................QL..NTAYL.KHHPRIWFWSS........GDNVTISWDS-QILCAG-...LPVWSATWGHYSISRNQFLTEVHAFNDRLMTEMSARVNFVC...............ERW.NRPKIYVDTQQLSKEQNDRSTWLQDAL.....QQPASTSWDKVLA-a...........................
A0A0Q8P3P5_9ACTN/3-237              ....................................................RFRFELTPVEDVRP.WG..SE...PP...ALHWFALTDGWYCIDVDGHELLRY.......SRQEPGDDEQN.----....PYVDYYVVRLWEDVIEVLPEALEPVPADLLDFVS..........RDVGRAS--------RENSPEAE-................EAGSWHADH..................AL..PMGHL.SEAPYIRWWRVtg....ddHDSVTVTW---QYRPGAE...IEFAAPMTGRVTMPTASFLAAVHEFDRSLLAEMELRVTALE...............TTG.APVGVELDLEHLRHEQRERATWLRRAL.....ERECATDWPAVRAG............................
A0A495JRD0_9ACTN/3-241              ....................................................RFHFGLDPLADVPP.WG..GD...QP...TLHWFGLTSGWYWIEADRHQLLRY.......SEQAVRRWDLA.---R....PYPHYYVVRLWEDLLVLRWALTEPVPADVVPFVD..........GTFGMRE-----FPEYDTGVEVD-................AAFGLQSDY..................HL..DMGYL.TDAPHIECWRQtd....agPDLVTI---SQRVPPGDQ...GTFVGPELLTISVPTADFFAAVHDFDRQLIAAMDERITELE...............RTG.PPAGVELDLDALRAEHVNRSRWLAERL.....AAPRQVDWDQIRSG............................
A0A1T3P8N9_9ACTN/2-247              ....................................................RFRFVLRAVEAVRP.WG..DE...AP...RLGWFILTDGWYWIEAGGHELLRY.......ADPARAEAFAG.PDAVr.epPYVDYHVVRLWEDLVDLMPRIMEPVPPDLADFVP..........DRRLRVE--------GSAAPDAE-................AAISWAEGH..................VL..DMGHL.RAAPDIRFRRAvs....ggDDTMTITWAH-ASEPDDDd.pIRFTAPATGRVSVPTEAFTAAVTDFDRDLFAAMEERVGALE...............ASG.PPPGVELDTIHLRHEHRDRATWLRRAL.....DRTPDTDWPAVRSG............................
F7NHZ2_9FIRM/43-207                 iceytinddkkpyewnlihivewlcnnlefilgydpfplpvqgdnileliqe--------------.--..--...--...------------------------.......-----------.----....----------------------------------..........------SDKFESEEDDELYLWYQ-................AKNSWLFRHs...............wfSS..RAGSM.LA--SVYFRRN........RNYIEVAWNNN-FFEDK-...QIFFTNPKGSYAVPKADFKKTIFDFLDNILSNLETKLG---...............---.---------------------------.....--------------rdakigdqsitglq..............
A0A0D8I0N3_RHOSX/1-182              ...................................................m--------------.--..--...--...------------------------.......-----------.----....-------VRLREDMLQALPYILEPVPNDLVDFVT..........AGWSIDF--DDIDDAELLDNTQID................AAIDAYSDR..................SV..DTGYL.RFGPELQWWRTl.....epVDTVNVDW-RFPVDPDGD...VAFTAPLSGRASGSTNEFVSAITDFDYLLLEAMQVRVDTIA...............ATD.VLSGFDLDIPGLIREQAERRTWLSQAM.....AHQVNTDWDAVRAG............................
A0A0M9YCD0_9ACTN/1-238              ...................................................m------TPLEEVKP.WG..-A...EP...KLHWFGLTAGWYCVDIDGHEVLRY.......SERTVRELRYDrDGDRa..hPYVDHFVVRLWEDVIALVSGAMEPVPHDLVDVAA..........AISPNWT-----WID---TPEAD-................AALTWHGEG..................YL..YTDYL.RVAPTIRLWRTvv....geEDTVTVGW-EHRADPEGV...IEFAGPQTGRVTLPTSEFLGAVAELDRALLAAMDERIGELE...............KSG.PPPGVRGDVEQLRREHRDRATWLRRAR.....DREPGTDWDAVRTG............................
A0A518EZY8_9BACT/2-247              ....................................................RFRFQLLPPEKIEP.WG.ePP...RQ...TLSWFALTDGFFSIDTDAGALCCY.......SPAVVERFGSE.---N....PGLEYQVAAMARDVLDAIPGALAPLPTALEDLMA..........EWPQF-SERLFSTEGRTADPDDHY................TATRWLGER..................SP..GFLYF.NVNPQVFFVRI........QDDIQISWDCRGRSIDGA...QAFADPLVGSFLVPVPAFIEEARRFADELLGAMENLINDLE...............SGA.RSAQIKVSAKDLRSQHKEWVKEFSAPFv...tPHEPDIEWDQVLA-a...........................
A0A3E0I062_9PSEU/2-78               ....................................................RFHFALTPLDQVRP.WA..-S...EY...WPHWFGLSDGTYWIELFGEKLLC-.......--------E--.-NDV....PYMDYYVARFWEDLLDATHDLLAGVPHNF-----..........------------------------................---------..................--..-----.-----------........------------------...-----------------------------------------...............---.---------------------------.....--------------nl..........................
F0EWQ9_9NEIS/23-296                 ....................................................LFDFTLKNIEQALA.FN..--...DA...SPYWFWLTDGSYNICINGKRLLSYnpdcltaEERAQVEQHAAaNGLPa.heP--DYYIVRLYEDLLS------EALP--------..........---YTWHNVGELAHQCLLNPTVDD................LAGEARWNSvildedndllakclfpngYL..GSGYM.LM-PEFRVWRY........ADEIYIYWNGNRTNENGI...PFFQHTGEAIFVISFDGFIHEVRDFHRRLMAAMAERIRQIQtdfpnfypvvrpivhQDGtPAGETVYDLAGLLAEHKEREQEFNQALqk.kwPIHPDFEQANLRAG............................
D1AI99_SEBTE/1-218                  ............................................mkkhdiks--------------.--..--...--...------------------------.......-----------.----....CFDDYYYIRQLEDLFEILPVISNSIPEDLYKYIYnekk.yknltKCFDNWIDEQKVFSDK--DEILDE................NICSFLSYG..................RL..DTGYL.NVKCCCCFYHV........SDQIIIHYDFEDFDEEN-...NPIWTAKSGRFTLTYKEFLDEIENLLNRFFCDMEKQISNAAaelkde..vfydifvQRD.--KNTKPGTAYLFEEHEERKISFYSVLrslknNNCKKINWDEIRE-n...........................
G0J4U1_CYCMS/1-257                  ....................................................MINFKLKHIDETQP.AG..AE...SD..lRMSWFWLTDGDLWLNLADSTLYEY.......SKDALKYFGDK.--KT....PYNDYPIVRFIEDFTKLFNAIKESIPHDIYQKTEnls....qflDDAHKWLDMNDTDEEEHSDFYFEEy..............dRLISWTYKR..................SL..NSGHL.IGGPQFSCFRN........KDKIRIVWETEYELENG-...IKLWTAKNGRIEIPYVDFILSIEEFGNQFFESMKEQVDLAV...............QKD.-WKEIQIDKERLIEEHKERESDFWEQFaqlknNSTGKTNWERIRK-l...........................
A0A402BBP2_9CHLR/2-267              ....................................................FFHFQLHPIAEIKP.WG.gKE...EP...VLHWFGLSDGWYWFQIGETEIFRY.......SKPFLAAYPPI.PHPP...rPYIDYYVVRLWEDILEIVPDIIDPLPAPLLQRMEsidq.wlnwcKKAEKWREDAREMCSEEESDARGEl.............lsTALEWWWRR..................HL..YTGPF.IITPGMHFWSD........GQIVHCLWDTRQAQFADD...QFIWEAIYGTKAIPVTTFMEAVTSFNERFIAAMAERVNTVL...............TNW.SRPEITIDFAHLAREHVQRSEHFASRMaevptRARTATAWEQCL--ea..........................
A0A429W8T2_9BURK/2-250              ....................................................LFNFAMVPLEEVQP.WG.kPG...RL...SLSWFGLTDSQYWVQAGTSVLLEY.......SDVARRLGSSR.----....-YCDYQVARLYEDVMALLPYILEPVPADLIQYISgdr...scvlERATAWHAANSERDDDLYWEIID-................GSSTWIGNR..................SL..HFSYL.SPSANILMWSD........ESLVHIEWDNRAKLVDG-...VCAWSAECGSHSLPRSEFEEEVRSFHKRLMDEMSVRVSRVV...............AGG.LPADVHVDVPGLLREHEQRKLLPASAF....eLPSPHTDWQAVRK-a...........................
U5W8B7_9ACTN/3-207                  ....................................................RFHFELTPLDGSLR.--..--...-S...KPYWFVLTDGTYGIRVGDQEVLE-.......-----------.----....PVADYYVARLWEDLALFTTIVLEPVPEDLVPFAA..........SEPEDWA---VDPGELPLDGSAM-................NAVVWHSEH..................YL..DLGYL.RRPPLFRIWRA........GDLVTARW----QKPDG-...------LAQSATMPAAALLDAVRQLNAELMKAMDERVTELE...............RT-.-----ESDTDWLRKEHRDRTTWLAQRL.....RDEPRTDWDDIRAG............................
A0A6B2TW14_9ACTN/1-155              .................................................mkq--------------.--..--...--...------------------------.......-----------.----....-----------------------DVPADLVDFVS..........GDSLGWNDV-----D---SDSAD-................AAMTWYSDH..................WL..NLGYL.RDSPAICCRRR........DGQVTIDWEMPVWAPNK-...--FAVPRTGAVTVDADQFVAAIEEFDRALLSAMEVRIAEVE...............ASP.-PLGVELDLDQLRREYQDRSGWLERAR.....GWHRSTDWDTIRAG............................
#=GC seq_cons                       ....................................................hhpFtLpslppl.P.WG.......p....phpWFuLT-G.YhlphsstpLhcY.......t..h.t..t.t.........sasDY.lsRLaEDlhslhsthhEPVPscLhthht..........tthtpWh......ts...s.pht.................sAhpWhsp+..................tL..shGYL.psuPplphWRs........tDplpltW.tpptpsss....h.hhsstsGphslstspFlstVcsFccpLhsAMcpRlsplt...............tps...stlplDhstLhpEppcRtphhtpth.....ttp.sT-Wstlcs.............................
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