#=GF ID   DUF6092
#=GF AC   PF19585.6
#=GF DE   Family of unknown function (DUF6092)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   27.00 27.00;
#=GF TC   28.00 42.90;
#=GF NC   25.90 23.80;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR046074;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001986) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, other (unspecified). This
#=GF CC   family includes a member from the purincyclamide biosynthetic
#=GF CC   gene cluster from Streptomyces chrestomyceticus and appears to
#=GF CC   be predominantly found in bacteria.
#=GF SQ   63
#=GS A0A410Q647_9FIRM/4-89     AC A0A410Q647.1
#=GS A0A848DEB9_9PSEU/10-96    AC A0A848DEB9.1
#=GS A0A4Y3QT91_STRCI/14-98    AC A0A4Y3QT91.1
#=GS A0A0S7BUG8_9CHLR/13-97    AC A0A0S7BUG8.1
#=GS A0A0B7ML06_9FIRM/8-92     AC A0A0B7ML06.1
#=GS K4LGD0_THEPS/9-93         AC K4LGD0.1
#=GS A0A1G8XXT2_9FIRM/9-91     AC A0A1G8XXT2.1
#=GS A0A2K2TQM8_9CLOT/4-89     AC A0A2K2TQM8.1
#=GS A0A3M2M3L0_9ACTN/11-95    AC A0A3M2M3L0.1
#=GS A0A160NXE2_STRLU/13-97    AC A0A160NXE2.1
#=GS A0A7K1FP62_9ACTN/9-94     AC A0A7K1FP62.1
#=GS A0A7W8AEG0_9ACTN/10-94    AC A0A7W8AEG0.1
#=GS A0A9W6P1B9_9PSEU/16-102   AC A0A9W6P1B9.1
#=GS S3BSA3_9ACTN/13-97        AC S3BSA3.1
#=GS A0A1R1ETS9_9BACL/12-98    AC A0A1R1ETS9.1
#=GS D7B1W7_NOCDD/13-97        AC D7B1W7.1
#=GS A0A1I7LHV0_9BACL/8-56     AC A0A1I7LHV0.1
#=GS A0A0J1INH7_NIACI/11-100   AC A0A0J1INH7.1
#=GS A0A2U1FFT3_9PSEU/10-95    AC A0A2U1FFT3.1
#=GS E4RP88_HALHG/7-98         AC E4RP88.1
#=GS A0A329R0E6_9ACTN/7-95     AC A0A329R0E6.1
#=GS A0A2N8PCT2_STRNR/14-99    AC A0A2N8PCT2.1
#=GS D4LU58_9FIRM/4-88         AC D4LU58.1
#=GS A0A1H3BPT8_9FIRM/11-93    AC A0A1H3BPT8.1
#=GS A0A5N8YTD7_9CHLR/10-95    AC A0A5N8YTD7.1
#=GS W0I4H6_9EURY/7-92         AC W0I4H6.1
#=GS A0A1Q4UXD0_9ACTN/13-97    AC A0A1Q4UXD0.1
#=GS A0A1V0AK25_9ACTN/3-87     AC A0A1V0AK25.1
#=GS A0A917X040_9ACTN/6-92     AC A0A917X040.1
#=GS A0AAE3GHD2_9PSEU/14-98    AC A0AAE3GHD2.1
#=GS F4CUQ5_PSEUX/13-99        AC F4CUQ5.1
#=GS A0A372LSY3_9BACI/15-101   AC A0A372LSY3.1
#=GS A0A919DR12_9ACTN/14-98    AC A0A919DR12.1
#=GS A0A174KET5_9FIRM/4-88     AC A0A174KET5.1
#=GS A0A975L9G2_9ACTN/12-97    AC A0A975L9G2.1
#=GS A0A0Q3QKS7_9BACI/22-108   AC A0A0Q3QKS7.1
#=GS A0A1V3ZZV8_9ACTN/16-100   AC A0A1V3ZZV8.1
#=GS A0A7V8NBP7_9ACTN/14-98    AC A0A7V8NBP7.1
#=GS A0A7Y7B1U2_STRMO/15-100   AC A0A7Y7B1U2.1
#=GS A0A133UYV5_9EURY/6-71     AC A0A133UYV5.1
#=GS A0A923LAS5_9FIRM/225-309  AC A0A923LAS5.1
#=GS A0A292YS60_9BACL/15-101   AC A0A292YS60.1
#=GS A0A1I1S8J6_9ACTN/23-108   AC A0A1I1S8J6.1
#=GS A0A0J1J249_9FIRM/8-94     AC A0A0J1J249.1
#=GS A0A2Y9BGM8_9FIRM/5-90     AC A0A2Y9BGM8.1
#=GS A0A4Q9HRR4_STRKA/15-100   AC A0A4Q9HRR4.1
#=GS A0A317LX08_9ACTN/12-97    AC A0A317LX08.1
#=GS A0A5D8QGB3_9THEO/6-91     AC A0A5D8QGB3.1
#=GS A0A511DDR0_9PSEU/11-97    AC A0A511DDR0.1
#=GS A0A934N9T2_9BACT/10-95    AC A0A934N9T2.1
#=GS A0A0K9XL38_9ACTN/14-99    AC A0A0K9XL38.1
#=GS A0A1I2RBS9_9FIRM/8-94     AC A0A1I2RBS9.1
#=GS N0BGA7_9EURY/8-93         AC N0BGA7.1
#=GS A0A964XP32_9ACTN/14-98    AC A0A964XP32.1
#=GS A0A3A4A687_9ACTN/1-85     AC A0A3A4A687.1
#=GS B2HLT0_MYCMM/15-99        AC B2HLT0.1
#=GS A0A3N0B7Z4_9ACTN/1-84     AC A0A3N0B7Z4.1
#=GS A0A1S2M3Y1_9BACI/4-69     AC A0A1S2M3Y1.1
#=GS W4RPE1_9BACI/15-99        AC W4RPE1.1
#=GS A0A429S3K9_9ACTN/10-96    AC A0A429S3K9.1
#=GS A0A934K3I2_9BACT/16-103   AC A0A934K3I2.1
#=GS A0A1Y4SCF8_9FIRM/4-89     AC A0A1Y4SCF8.1
#=GS A0A2M9M7J8_9ACTN/15-101   AC A0A2M9M7J8.1
A0A410Q647_9FIRM/4-89                ..........n-ESFELLAYLVAGAAGLEGEPRIYGPLRMIEAAERLCKLMLAD..D....PEN.SSLKELVEIIENGKRKTMSD..EAGFYQMLRDAAAKLVD.CV...
A0A848DEB9_9PSEU/10-96               ...........DQALELLAYLVTAARTQVDEAAEYGPMRLLTAAGRLAAMIRPR..-....ASE.GLQDVLAGPLGSVPPTAVPRtgREAYVARLDGICRELAE.HL...
A0A4Y3QT91_STRCI/14-98               ...........EDLVLLTAYLLSTGHGLLHEPAAYAPARAVDAARRTLGLLAEH..D....GPD.RRLDEVRARIDEFFTDPHD-..GEPLAELLDELCVRMAE.VV...
A0A0S7BUG8_9CHLR/13-97               ...........NELFMLVSYVITSARGLYDEPDNYGIFRLIDSAGRLLAIMESA..G....MSD.DFIASLREQIDEERESSMD-..DDAQKRHLDAMVLKIAR.EL...
A0A0B7ML06_9FIRM/8-92                ..........t-KFYELFCFILTSARGCVDEPPIYGPLRLLDTYSRLIDALDE-..G....SVD.PFWQELKEQIDSYKNDAMYD..AEGFVKAIDQTLAAVAQ.HI...
K4LGD0_THEPS/9-93                    ..........n-KLLDLLCFMVTSARGCLDEPPGYGPLRLLEAYAMLIDALNE-..G....NIP.AVFLEERKNIEGYLMLCMYD..EKSFQEELDRTVARIAR.AL...
A0A1G8XXT2_9FIRM/9-91                ...........EELEEIMFFLITSARGCIDEPASYGPLRLLEAASRLTDVVG--..-....KHN.DSYIKLKDEINNSMDIALID..EEKFQEQLDDIILHLAK.EV...
A0A2K2TQM8_9CLOT/4-89                ...........NDYFELLVYMITSAAGLEGEPRIYGPLRMIEASQRLCRLILSE..D....PEN.QNLKELIELIENGKGKTMSD..EKAFYQMLQDAAAKLVD.CI...
A0A3M2M3L0_9ACTN/11-95               ...........EELLLLTAYLLSSGRGLFDEPRAYGPLRCADAARRALALAEQS..G....IDN.EEVHAIRTRLDDVVQGAMG-..ETQLDDLLDHLCERMAT.VL...
A0A160NXE2_STRLU/13-97               ...........EELILLAAYLLSCGRGLLDEPQVYGTFRCIDAARRVLVLLKDR..G....LDN.SELLALHSQLEDFMCGPMI-..QRDVTGFLDEVCLRLTL.--ql.
A0A7K1FP62_9ACTN/9-94                ...........QELFEVIVYLVSSSVTSMTETPELATFRMIDAAERLMAISTSR..-....LPD.DFLTAARADWEAHKMLVVSD..QPEYLRWLDGYARSFVR.--ktl
A0A7W8AEG0_9ACTN/10-94               ..........r-ALYETVTVLVCSAPLALDETRLLSAFRMLDAADRLMGIMADH..-....-DD.DFLRRARADFADHRMLAMTD..QAAFTDWMSRYVAGFAA.--qal
A0A9W6P1B9_9PSEU/16-102              ...........DEALELLAYLVTAARTQVDEAAEYGPLRLLTAARRLGSAIAPR..-....ASA.ATAGFVAGPLAAVPELAVPRdgREEYAARLDELCRALAG.HL...
S3BSA3_9ACTN/13-97                   ...........EELVLLAAYLLSCGRGLLEEPQAYGPLRCLDAGRRVLTLVEQA..G....LHD.ERLSAVRARLDDCMCGPME-..YRDLPGFLDEVCGSLIT.AL...
A0A1R1ETS9_9BACL/12-98               ...........ERMLDFAAYVLTSARALYREPHSYGPMRLADTLEKGLELLQAA..G....IRD.ETVEQAMAAVRESRPVAMTD..PEGFAEALDRAIAVLVQ.--atl
D7B1W7_NOCDD/13-97                   ...........EELLLLAAYLLSSGRGLLDEPRQYGTFRCLDAARRVLALAAGT..G....PHH.PELDALRGRMDDVMCGPMG-..DHELDTLLDQMCERLAT.VL...
A0A1I7LHV0_9BACL/8-56                dgtqrdrdalrETLRDYIGYVLTSARGLYGEPLSYGPMRMFDALEKS-------..-....---.--------------------..-----------------.--lv.
A0A0J1INH7_NIACI/11-100              .....klvelv---RDYSGYILTSAKGLYREPAHYGPLRMVGALERTLVLLTEL..G....IED.KEMEEVLSFIRKEGWRALSD..PLGYEKALDKSIDQLVE.--ltv
A0A2U1FFT3_9PSEU/10-95               ...........DDALELLAYLVTAARTQVDEAAEYGPMRLLTAAHRLAEAMGPR..-....SSP.ETAAALGGPLAAMPTLAVPR.dRTEYVEQLDAACRSLAA.HL...
E4RP88_HALHG/7-98                    ..........k-EVLKLISHMTTSARGLIDEPKSYGPFRLIDSTIKLYQTLEKA..DvikeKNE.TDLDEIISELDEIKRECLAEdcQEDCAENLDSIINKLVV.EL...
A0A329R0E6_9ACTN/7-95                ..........q-AIFGIITHLVTSAPTSLQETPSLAAFRMVDAAHRLMELVNEN..Dt..fQQD.EFLQSARAEYMANFNLVMTD..PDAFDAWLASYVQSFTR.--eal
A0A2N8PCT2_STRNR/14-99               ...........EEIALLAVYLLSSGRGLLEEPADYGIYRCTDGARRALQLLDEH..G....GST.ARLTAVRERLDEVMFAPMGE..DRDMGAILDDLCRQMAD.AL...
D4LU58_9FIRM/4-88                    .........pe---FELLVYLITSARALPEEPASYGSIRLTEAASRLCRIICNN..D....PDN.KTYCELLNCIEADKGKALTE..PERFSAMLEKASEILVD.CL...
A0A1H3BPT8_9FIRM/11-93               ..........d-ELDKAVCYILTSAKSYVDEPRSYVPMRLLESASIILDILS--..-....IYD.NKYLWLNEEINRIKLLPLES..EAEYLREIDIILTRLIE.--sy.
A0A5N8YTD7_9CHLR/10-95               ..........s-EAIELLAFLITAARTQIDEPPDYAPMRMLTAAGRLREFILDR..-....VSP.EGHQFLKEFLNPAPKSFRQA.gLEQYSASLDELCRKIAR.HL...
W0I4H6_9EURY/7-92                    ..........d-DHFKLLAFLITSARGCVDEPPLYGPLRLVDAASRLIEIMRKE..G....KVN.EQIIKLQKMIKEKMDLVMYD..EEMFIEFLDELSKELAK.IL...
A0A1Q4UXD0_9ACTN/13-97               ...........EELLLLTAYLLSSGRGLLEEPQQYGPFRCIDAARRVLVLLRDR..G....VTN.SELQELHGRLEDFMCGPMA-..PRDLTAFLDEVCGKLT-.--lll
A0A1V0AK25_9ACTN/3-87                ...........EELLLLAAYLLSSGRGLLDEPAAYGPLRCLDAARRVLALAIRA..G....AGN.EDVAALRAELDDVMCGAMT-..ERDLDHFLDHLCERLGA.--ll.
A0A917X040_9ACTN/6-92                ...........DEALELLAYLVTAARTQLDEAAEYGPLRLLTAAQRLAGYLAPR..-....VSP.ETRSLLEGAIQRVPQTATRSadPDGYAAALDAMCRALAE.HL...
A0AAE3GHD2_9PSEU/14-98               ..........e-GIALLAAYLLSSGRRLLEETPGYALYRLLEGARRALELLETA..G....EAT.PDLVAVRSQLDGVVFGPPA-..DRDFATLLDNLCAGLVT.AL...
F4CUQ5_PSEUX/13-99                   ...........DDAIEVLAYLVTAARTQVDEAAEYGPLRLLTAARRLAGLLAPR..-....ASE.PTATFVRDHVEPMPELAVPRqgRDEYVARLDGLCAELGS.--ll.
A0A372LSY3_9BACI/15-101              ...........EHLRDYVAYALTSAKGLYREPQSYGAMRMFDAMERALRLLQEV..G....VKD.EALEEALTTVRKQRWQAMTN..PDAFGKAIDDSILNLVD.--iti
A0A919DR12_9ACTN/14-98               ...........EELVLLVANLLASARGLLDEPKDYGPMRCLGAACRVLELLEQA..D....ASE.QRLVTVRKRIEDVLTGPQN-..HDHTAAFLDELCEQVAV.A-v..
A0A174KET5_9FIRM/4-88                .........pe---FELLVYLITSAKALPEEPACYGSIRLTEAASRLCKIICEK..Y....PEN.DAYRALLGCIDADKGKALTE..PEGFAKMLEKASEMLVD.CL...
A0A975L9G2_9ACTN/12-97               ...........EELALLAAYLLSSGRGLLEEPEAYGPLRCLDAARRVLALRSGF..G...yPDS.PELTALRASLDDVMCGAMA-..DRELDVLLDELCDRLAA.AL...
A0A0Q3QKS7_9BACI/22-108              ...........EDLLDYVAYTLTSAKGLYREPHSYGPMRMIDSMEKALHLLKEA..G....IQD.EALEEGLAAVRNARWKAMTE..SEEFGKAMDESILNLVD.--itv
A0A1V3ZZV8_9ACTN/16-100              ...........EQIALLAAFLLSSGRGLLEEPTAYGPARCADGARRTLELLERY..G....PCD.ARLVALRTRLEEAMSGPMG-..EVDLVALLDDACDRMAE.VL...
A0A7V8NBP7_9ACTN/14-98               ...........EDLVLLAGHLLSCASGLVEEPAYYGIFRCMDSARRTLEVLAEH..A....ELD.PRLAELRDELERTVSGAQN-..GQSVEEFLDDVCLRMAR.I-v..
A0A7Y7B1U2_STRMO/15-100              ...........EEIALLAAYLLSSGRGLLEEPADYGAFRCADAARRTLEILEKA..G....AST.PALTAVRERLDGVMFSPMGG..DIDLAGILDELCLQTAT.AL...
A0A133UYV5_9EURY/6-71                .........dp--FYDLICYIATSARGCVEEPKIYGSFRLIETMERVINILEEE..G....YAD.DFYLNLRDKINDERNR----..-----------------.--ktr
A0A923LAS5_9FIRM/225-309             ...........KELQDLLIYMITSAAGLPGEPHMYGPLRLIESSRRLAGMLSAA..-....YGG.EVFGELTALIDAGKGRNMTD..PEGFCEMLQEAAAKATE.L-l..
A0A292YS60_9BACL/15-101              ..........n-RLLDYVSYVLTSARGLYKEPHSYGPMRMVDSLEKALFLLRDM..G....IKD.DAIEESVAVIRENRWRVTSD..PEAFAQALDDAILRLVK.--vtl
A0A1I1S8J6_9ACTN/23-108              ..........e-GLTLLAAFLLSSARGLLNEPPGYGVARCADGARRTLELLDLC..G...gGPD.PRLVRVRERLEETMCGPMS-..AADFPALLDRALDEVVS.V-i..
A0A0J1J249_9FIRM/8-94                ..........d-RCFELLVYLVSSAAGLKKEPHIYGSLRLIEASRQLGQILADA..D...dTKS.AAFTELIDTIENSKNKCMTD..QDAFYQMLEEASLKLVD.C-c..
A0A2Y9BGM8_9FIRM/5-90                ...........EAYMELLIYMITSAAGLENEPHIYGPLRMIEASQRLCGLMQEE..D....PDN.EDLKELIRIIENGKQKSTSD..EEAFYQMLQDAAAKLVD.LL...
A0A4Q9HRR4_STRKA/15-100              ...........EEIALLAAYLLSSGRGLLDEPADYGAYRCADAARRTLGILEQA..G....AST.PQLSGIRHRLDEIMFSPMGG..DLHLPEILDDLCLQLAG.AL...
A0A317LX08_9ACTN/12-97               ...........EELVLLAAYLLSSGRGLLEEPAAYGPLRCLDAARRVLSLRSRI..G...vPDS.PELTDLRARMDDVMCGAMA-..DRELDVLLDDLCDRLAA.AL...
A0A5D8QGB3_9THEO/6-91                ..........v-DYRDVLAFMVTSAVGLFHEPKLYGPLRLLESASMLIEYAKGN..D....IQD.ETLDEINSRIKKCTKLVMTN..EEKFEEGVNEILKLIIE.AL...
A0A511DDR0_9PSEU/11-97               ...........DDALEVLAYLVTAARTQVDEAAEYGPMRLLTAARKVADRLASR..-....ASE.PTAAFARDHVDPMPELAVPRegREEYLARLDALCAELGS.V-l..
A0A934N9T2_9BACT/10-95               ...........EQALVLLAHLVSSADICRFEPHFYGTFRLVDAASRLIGSMLEN..G....CED.EWLRDFHAEIERKKTWMMWD..REAYFAFLPEAARELAG.EL...
A0A0K9XL38_9ACTN/14-99               ...........EDIALLAAYLLSSGRGLLNEPSDYGAFRCADAARRTLEILERA..G....GSS.PGLTEVRERLDGVMFAPMGG..DTDIAAVLDELCLKMAD.SL...
A0A1I2RBS9_9FIRM/8-94                ...........EAYYDLLGYVVSSAKELVVDPKLYGPLRLVDTASRLIGILMEE..G....RSD.DFLVSLKDYIDENKHLVMTD..EAEFIAFLNELVVKVAEfT-l..
N0BGA7_9EURY/8-93                    ...........KEFFELLCYVLTSARGLMDEPKMYGPFRLVDTASRIISILEKH..G....IAD.DFLAEERKKIDEGKYSVMES..EEKFKEFLDRIIQDFAE.EL...
A0A964XP32_9ACTN/14-98               ...........EDIAVLAAFLLSSAIGLPHQPPKYGPFRFMDAARRTLRILEDG..G....VQN.PALASVRQQIESALFAPIE-..NMDFAELLEGLALETAH.--gl.
A0A3A4A687_9ACTN/1-85                .........mr--IAHVAAYLLASGRTMLSEPMEYGPFRLLDGARRALALLEGD..D....ETY.ARFASIHDRIQEVFQTVRL-..DIDLPTLLDELCLEMAA.--gm.
B2HLT0_MYCMM/15-99                   ...........DELVSIVAYLLGSAALTDQEAPAITALHFVGAGMRILEIVAQE..-....TDD.DFAQAKMKTIEQRIQQVLGD..PAALSEYLHCIAKEFAK.EV...
A0A3N0B7Z4_9ACTN/1-84                ...........---MELLVYMVTSAAGLQGEPEAYGPLRLIEASKRLALMLAEE..D....ADRaAALQELAQLIDERKNDCMTD..EDSFYAMLNDAAAKLVE.CV...
A0A1S2M3Y1_9BACI/4-69                .........nv-----------------------MGQLRMIDSLEKSLVLLKNA..G....VDI.QTVDNAMATIRKDRWRATSD..PEAFANAIDRAIDELVN.--vti
W4RPE1_9BACI/15-99                   ...........EHLLDYVAYTLTSAKGLYREPQSYGAMRMVDAMERALRLLKEV..G....IED.EVLEDALSAVRKDRWRAMTD..KEGFGKAIDDSILNLVN.--i..
A0A429S3K9_9ACTN/10-96               ...........DDAVELLAYLVSAARTQVDEAAEYAPLRLLTAAGRLADMIAPAasD....GLR.PFLEDIRQGFGET-TLAAGD..PDGYVDRLDGLCRTVAL.HL...
A0A934K3I2_9BACT/16-103              ...........EEAIELMTYLLASAECCTREPLYYGSFRLLDGVSRLAGYVLDR..Et..sPRD.SWLSDFKAEIDQKKAWVMLD..REGYFEFLQEAAGRIAE.R-i..
A0A1Y4SCF8_9FIRM/4-89                ...........EDYFELLVYMITSAAGLKGEPKIYGPLRMIEASERLCSLMLKE..D....PDN.PDLKELREIIETGKQKTTSD..EEGFYQMLQDAAAKLVD.M-v..
A0A2M9M7J8_9ACTN/15-101              ...........EELALLAVYLLSSGRGLLDEPPDYGAFRCTDAARRVLHILEAD..G....PLG.PEMAAVRGRLDDFMFAPMGG.dDVDLAGLLDEACLQMAV.AL...
#=GC seq_cons                        ...........c-hhcLhuYLloSARGLhcEPttYGPhRhl-AAcRllpllppt..s....sss.stlppl+spl-pshttshsp..pcsasphLDchstclsp......
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