#=GF ID DUF6196
#=GF AC PF19696.6
#=GF DE Family of unknown function (DUF6196)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 27.00 27.00;
#=GF TC 31.90 108.20;
#=GF NC 26.50 22.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 26754528
#=GF RT Target-specific identification and characterization of the
#=GF RT putative gene cluster for brasilinolide biosynthesis revealing
#=GF RT the mechanistic insights and combinatorial synthetic utility of
#=GF RT 2-deoxy-l-fucose biosynthetic enzymes.
#=GF RA Chiu HT, Weng CP, Lin YC, Chen KH;
#=GF RL Org Biomol Chem. 2016;14:1988-2006.
#=GF DR INTERPRO; IPR045674;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0001381) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, polyketide. It includes a
#=GF CC member from the brasilinolide A biosynthetic gene cluster from
#=GF CC Nocardia terpenica [1]. This family appears to be predominantly
#=GF CC found in bacteria.
#=GF SQ 48
#=GS A0A5C8JC59_9ACTN/1-144 AC A0A5C8JC59.1
#=GS A0A1M7CWF2_9GAMM/1-142 AC A0A1M7CWF2.1
#=GS A0A8J4E002_9ACTN/11-148 AC A0A8J4E002.1
#=GS A0A2W2CTW3_9ACTN/1-145 AC A0A2W2CTW3.1
#=GS A0A8J3N6A2_9CHLR/1-142 AC A0A8J3N6A2.1
#=GS A0A1A9HKV7_9BURK/1-143 AC A0A1A9HKV7.1
#=GS A0A2P2E9W7_9PROT/33-176 AC A0A2P2E9W7.1
#=GS A0A847S3C8_9NEIS/1-144 AC A0A847S3C8.1
#=GS A0A7K1KUP7_9ACTN/1-144 AC A0A7K1KUP7.1
#=GS A0A1E5PK66_9ACTN/1-144 AC A0A1E5PK66.1
#=GS A0A3A4AUJ3_9ACTN/1-144 AC A0A3A4AUJ3.1
#=GS A0A1V2QHW3_9PSEU/1-142 AC A0A1V2QHW3.1
#=GS A0A7W3LZR3_ACTNM/1-144 AC A0A7W3LZR3.1
#=GS A0A1I2NCC4_9ACTN/1-142 AC A0A1I2NCC4.1
#=GS A0A0U1YZI8_9NOCA/1-144 AC A0A0U1YZI8.1
#=GS A0A563VR28_9CYAN/28-170 AC A0A563VR28.1
#=GS K0F1K8_NOCB7/1-144 AC K0F1K8.1
#=GS Q124B1_POLSJ/1-148 AC Q124B1.1
#=GS A0A640V156_9ACTN/1-144 AC A0A640V156.1
#=GS F2LLC7_BURGS/1-143 AC F2LLC7.1
#=GS A0A931DRM9_9ACTN/1-139 AC A0A931DRM9.1
#=GS K4QWM2_STRDJ/17-160 AC K4QWM2.1
#=GS A0A7W5YDB8_9ACTN/1-144 AC A0A7W5YDB8.1
#=GS A0A0X3UP01_9ACTN/1-142 AC A0A0X3UP01.1
#=GS A0A1S6JBH3_9ACTN/1-144 AC A0A1S6JBH3.1
#=GS A0A5S4FMK5_9ACTN/1-144 AC A0A5S4FMK5.1
#=GS A0A0S2F5L3_LYSAN/1-143 AC A0A0S2F5L3.1
#=GS A0A8J3Y108_9ACTN/1-141 AC A0A8J3Y108.1
#=GS A0A1I1PT35_9GAMM/1-135 AC A0A1I1PT35.1
#=GS A0A919V1V9_9ACTN/1-138 AC A0A919V1V9.1
#=GS A0A927BHM5_9BACT/1-137 AC A0A927BHM5.1
#=GS A0A5B9EET7_9BACT/1-142 AC A0A5B9EET7.1
#=GS A0A420XQL2_9ACTN/1-144 AC A0A420XQL2.1
#=GS A0A5J6HSE9_STRAD/1-142 AC A0A5J6HSE9.1
#=GS A0A255Z8C7_9FLAO/1-139 AC A0A255Z8C7.1
#=GS D3PUE5_STANL/1-142 AC D3PUE5.1
#=GS A0A4R4XHZ7_9ACTN/1-144 AC A0A4R4XHZ7.1
#=GS A0A4S4ZK59_9ACTN/1-142 AC A0A4S4ZK59.1
#=GS A0A2R4SVP7_9ACTN/1-144 AC A0A2R4SVP7.1
#=GS A0A8T4HLP6_9ACTN/1-142 AC A0A8T4HLP6.1
#=GS A0A1S8FIE5_9BURK/1-149 AC A0A1S8FIE5.1
#=GS A0A0B6S3B3_BURPL/1-143 AC A0A0B6S3B3.1
#=GS A0A1M5FM80_STRHI/1-144 AC A0A1M5FM80.1
#=GS A0A944E8R0_9ACTN/1-142 AC A0A944E8R0.1
#=GS A0AA41TZB6_9ACTN/1-144 AC A0AA41TZB6.1
#=GS A0A1H0B3Z0_9ACTN/1-144 AC A0A1H0B3Z0.1
#=GS A0A3A1TV94_9MICO/1-145 AC A0A3A1TV94.1
#=GS A0A6N7EX52_9GAMM/1-143 AC A0A6N7EX52.1
A0A5C8JC59_9ACTN/1-144 .MVSVSRERPEQTEERLQRVIAQADVLVHDGVWCFEEFPIDQPPVL.....TGDELAVVRDDQSWSRLVPYSQE.hEHVERFGIFSFHFPSELDNSGFVGWLASHLKVRLGTGVFVICGSNRARGGIYDYWGCPVDLLDEAVAVVKALRA-a.
A0A1M7CWF2_9GAMM/1-142 m--YISYETPSQTSTRLGQVIASAEFVVYDQPYTFVETDVSSFPKE....lLTTALAFVRDENVWSALVPSVE-..PEHEKFVVFSFHFTENLDNSGFVGWLASHLKVVLGTGVLVICGQNSQRGGIFDYWGAPLSVASQVIAEIRNLR--ge
A0A8J4E002_9ACTN/11-148 .MVSISAERPVESERRLRAVLRTTRLAHLPGAWCFRRIAGAP----.....SADAIATVRDVDGWCALVPAAR-..DSGERFGLTMSTFAPDVDNSGYVGWLATVIKQRLGSGVFVVCGDNPGRGGIFDYLGYPLELAAAVHALIDELRR-p.
A0A2W2CTW3_9ACTN/1-145 .MVDVSRETEDQTDQRLRQVIAAAELVVHDGIWYFEESPASSPPPL.....SAQTLAVVRDQDSWSALIPMTHEptEPVERFGVFSFHFPPGVDNSGFVGWLATHLKRRLGTGVFVVCGSNRARGGIYDYWGCPHNLLPEAVAVVKELST-q.
A0A8J3N6A2_9CHLR/1-142 .-MDISYETPEQTQQRLLQVIAHAQLHVLDGAYAFEEFPLSDFLRR....vTPSALALVRDDEVWSQLVPSTD-..RTQELCTVFRFHFEAGLDNSGFVGWLASHLKVQLGTGVFVVCGFNSQRGGIFDYWGCPVAVGSQVIAEVERLRN-q.
A0A1A9HKV7_9BURK/1-143 .MVDISRETVEQTERRLRRVITQARLRVYPGTWAFEEFPLDSFATS....vRPDALALVRDDAVWSQLVPSED-..AGADLFGLFRFHFPAGADNSGFVGWLATHLKTRFGTGVFVTCGQNHGDGGIFDYWGVPAVLAESVIAEVQSLVN-a.
A0A2P2E9W7_9PROT/33-176 .LVHVSQESPAQTQARLAMVLAQARWWVAPQLYRFEEFPDTEFAHR....iNHQALALVRDGHVWSQLVPCGDG..QQDDAFTIFSFHFPEGLDNSGFVGWLASLIKQQVGTGVLVICGQNRAAGGIYDYWACPPQCRDAVLDLITRLR--la
A0A847S3C8_9NEIS/1-144 m--YISQETPEATHARLCQVLAQAELVVHEGAYTFMETPVSAFPLH....aLEHALAFVRDDAVWSALIPCQEG.aDDPEAFILFSFHFPPGLDNSGFVGWLASHLKARVGTGVMVVCGQNTARGGIFDYWGAPLAVGEAVIQAVHQLR--gn
A0A7K1KUP7_9ACTN/1-144 .MVGVSVETAEQTEARLRGVIAQAELVVHDGVWGFEEFPADQAPAL.....TAETLAVVRDEESWSRLAPAVPG.rGGAERFGVFSFHFPADQDNSGFVGWLATHLKAELGTGVFVICGSNQARGGIYDYWGCPIDMLAEAVAVIEALRT-g.
A0A1E5PK66_9ACTN/1-144 .MVSVSMETAEQTEQRLRRVIAQADLVVHDGVWCFEESPADQPPAL.....SAETLAVVRDRESWSRLVPLTQE.gNGVERFGIFSFHFADHVDNSGFVGWLATHLKVELGTGVFVVCGSNRARGGIYDYWGCPIDLLDQAIAVVRTLRD-s.
A0A3A4AUJ3_9ACTN/1-144 .MVSVSVETPEQTGERLRRVIAEAELLVHDGVWGFEESPADRPPAL.....TGDELAVVRDDESWSRLVPLTRE.rEGVERFGVFSFHFPEGLDNSGFVGWLASELKARLGTGVFVICGSNRGRGGIYDHWGCPIDLFDEAVAVVGDLRA-s.
A0A1V2QHW3_9PSEU/1-142 .MVSISQESPEETEQRLLRVIAAARLGALDGDWSFFEAPLADPPTL.....DADTLAAVRDEDRWSWLAPANG-..TATERFALFSFHFPADLDNSGFVGWLATELKLRLGTGVFVVCGQNSDRGGIYDYWGCPAQLREQAAQVLHELR--ga
A0A7W3LZR3_ACTNM/1-144 .MVSVSRETAEQTEERLRRVIAQADLLVREGAWCFEESPLDRPPAL.....TADTLAVVRDEESWSRLVPSAGE.gGDAERFGVFSFHFPEGLDNSGFVGWLAGRLKASLGTGVFVVCGSNRDRGGIYDHWGCPVDLLDEAVAVVEALRA-g.
A0A1I2NCC4_9ACTN/1-142 .MVSISQESPEQTWQRLRGVIAAARLRTFDGEWSFFEAPLTDPPAL.....TADLLAVVRDDDRWSWLAPAGP-..SAGERFALFSFHFPPEMDNSGFVGWLATELKRRLGTGVFVVCGQNSDRGGIYDYWGCPAELRAEAAEVLRELRA-g.
A0A0U1YZI8_9NOCA/1-144 .MVSVSIETAEQTEQRLRRVIAEADLVVHDGVWCFTECPADQPPTL.....TGGTLAVVRDQESWSSLVPFTED.sDGVERFGIFSFHFPDGADNSGFVGWLATHLKSELGTGVFVVCGSNRARGGIYDYWGCPVDVLDQAIAVVGKLRN-d.
A0A563VR28_9CYAN/28-170 .MVEISHETAAQTEDRLLKVIAQSEFKIFAESYVFEEFTINNFSNL....aRQDALALVRDHEVWSQLIPSND-..ATKEQFKIFSFHFDDCADNSGFVGWLASHLKTKLGTGVFVTCGQNLQRGGIFDYWGCPLEISDNVIDEIEKLI--ve
K0F1K8_NOCB7/1-144 .-MDISIETEDQTAQRLRRVLASAELEVQPGVWCFRESPLAEPPQL.....SDRTLAVVRDAESWSALVPFAAAegPDVEKFGLFSFHFPTGMDNSGFVGWLAGHLKRALGTGVFVVCGSNRERGGIYDYWGCPVELLAAVEREIETLRS-p.
Q124B1_POLSJ/1-148 .-MDITPETPEQARQRLLRVMAHARVDVLPCDYTFAEFPVAQFPADlasslASNALALVRDQAVWSALVPASAQ.tKAEDCYTVVCFHFAPNIPNSGFVGWLASEFKRQLGTGVFVVCGHNSADGGVFDYWGIPNSVARQATSLIHAMQS-q.
A0A640V156_9ACTN/1-144 .MVSVSMETAEQTEQRLRREIAQADLVVHDGVWCFEESPADQPPAL.....TAATLAVVRDRESWSRLVPLTQE.dDDVERFGIFSFHFDDHVDNSGFVGWLATHLKVELGTGVFVVCGSNRARGGIYDYWGCPIDLLDQAITVVRALQD-n.
F2LLC7_BURGS/1-143 .MVDISRETAEQTELRLRRVITQAQLVVYPGLYRFDEFPLDRFPDA....aRSDALALVRDDHVWSQLVPCDE-..TRYERFGLFRFHFPEHADNSGFVGWLATHLKRRFGTGVFVTCGQNSAAGGIFDYWGVPAELADLVFQEVGRLVQ-g.
A0A931DRM9_9ACTN/1-139 m------ETAEQTEQRLRRVIDQADLVVHDGVWCFEESPADQPPAL.....TPETLAVVRDQESWSRLVPVAQE.gDGVERFGVFSFHFPGQADNSGFVGWLATHLKAELGTGVFVICGSNRARGGIYDYWGCPIDLLDQAIEVVRALR--vs
K4QWM2_STRDJ/17-160 .MVSVSVETAEQTEQRLRRVIAQADLVVHDGVWCFEESPADQPPAL.....TGETLAVVRDRESWSHLVPLTQE.gDGVERFGIFSFHFADHVDNSGFVGWLATLLKVELGTGVFVVCGSNRARGGIYDYWGCPIHLLDQAIAVVRTLRA-t.
A0A7W5YDB8_9ACTN/1-144 .MVSVSVETRQQTEERLRQVISMADLTVHDGVWHFEEFPADRPPAL.....TDDTLAVVRDSESWSRLVPLPRD.gGESERFGVFSFHFPADLDNSGFVGWLASHLKAELGTGVFVICGSNRARGGIYDYWGCPVELLQEAVAVVEALRA-g.
A0A0X3UP01_9ACTN/1-142 .MVSISQESVGETDRRLRRVVAAADLVTFDGEWSFFEAPLDRPPVL.....TAELLAVVRDDDRWSWLAPSGA-..SEGERFAVFSFHFPPGVDNSGFVGWLATEFKRRLGTGVFVICGQNSDRGGIYDYWGCPAQLRAEAAEVLADLRT-g.
A0A1S6JBH3_9ACTN/1-144 .MVSVSVETAEQTEERLRRVISEADLVVHDGVWCFEESPADQPPAL.....TGDTLAVVRDQESWSRLVPLTRE.gDGVERFGIFSFHFAGQADNSGFVGWLATHLKAELGTGVFVICGSNRARGGIYDYWGCPVDLLDRAVAVVRALR--pd
A0A5S4FMK5_9ACTN/1-144 .MVSVSMETPEQTEERLRRVIARADVLVHDGVWCFEESPIDQSPVL.....TGDTLAVVRDDQSWSRLVPLTQE.qEHIERFGIFSFHFPADLDNSGFVGWLAGRLKVRLGTGVFVICGSNRARGGIYDYWGCPIDLLDDAIAVVEALRA-g.
A0A0S2F5L3_LYSAN/1-143 .MVDISRETIEQTNTRLLVVTKQARLLAYPGTYAFVEFPLADFPVA....vRADALALVRDDEVWSQLVPCTD-..PAEDLFALFRFHFPSRVDNSGFVGWLASRLKRKFGTGVFVTCGQNRRDGGIFDYWGVPVAVAAEIAAELDALV--sp
A0A8J3Y108_9ACTN/1-141 .MVNVSADTPEQTEARLRQVIARCDFVVRDGLWLFTESP--EPPRL.....TREALAVVRDEQVWSSLVPAGED.sPGAGRFGVFSFHFPPDMDNSGFVGWLATLLKRELGTGVFVVCGSNTARGGVFDHWGCPADVLPLAVKIVEGLR--s.
A0A1I1PT35_9GAMM/1-135 m------ETVEYQNIRLTKAFSHSDVNFLPDSYDYEEFDSEELNLK....lNPEALALIRDGDRWSQLVKKES-..---GAFVAFSIHFNGIDNVNGFVGWFASYLKVKLGIGLIVFVGSNSLKNGVYDYYGVPIEHIVAVKREVAMLA--si
A0A919V1V9_9ACTN/1-138 .MVSISHERQVESERRLRAVLRAAELAHLPGAWCFQRFDGDP----.....PFAALATVTDVDGRCALAPATP-..DAVERFGVTLTTFAPRIDNSGYVGWLATTIKQRLGSGVFVICGDNPRRGGIFDYLGYPLEVAGAVRGLLDELRR-p.
A0A927BHM5_9BACT/1-137 m--YVSQETTQQIEARLLSVLRQAHLKLYSGTYCFEEYPRAE-YVF.....NPNALAIVGDDEVWSQLVPCED-..ASNELFTVFSFHFTPGLDNSGFVGWLASKIKSQTGSGVFVVCGQNSAKGGIFDYWGCPIAVAEEVIKVVT-----sa
A0A5B9EET7_9BACT/1-142 m--YVSQETTEQTDSRLRRVIAAAELTWHEGPFAFYEFPVEAFPTS....eAERGLAIVRDNEVWSVLKGAGP-..EAAEPFGLFSFHFQDGLDNSGFVGWLASILKRNLGTGVFVVCGQNSRRGGIFDYWGVPLAMRNEAMSLLKELRH-d.
A0A420XQL2_9ACTN/1-144 .MVSISRETPEQTHARLRSVLARAEMTVFDGVWSFAETPLDEPPQL.....SAATLAVVRDEDSWSALVRDDVQ.dAGRERFGLVSFHFPAGVDNSGFVGWLAGELKTRLGTGVFVVCGSNRARGGIYDYWGCPVGLLDDVVGVIRGLG--as
A0A5J6HSE9_STRAD/1-142 .MVSISHESPQETRARLRDVLADADFEVLPGTWAYHEYPAGPVPQP.....SAEALALVRDAQSWSVLEPARG-..GEAEVFGVLAFHFPSASDNSGFVGWLAGELKERLGTGVAVLCGYNSAQGGIYDYWLVPVQLLGEARAHVRSLAA-e.
A0A255Z8C7_9FLAO/1-139 m--YISSETPEQTDNRLRKVIQTSELKIYDVEYFFKECPIEKF-EL.....DERALAIVRDEEVWSFLIPSES-..SETENFKLFSFHFKDGLDNSGFVGWLASTIKRELGTGVFVVCGQNTRRGGIFDYWGCPASIADDVIELVRKLR--d.
D3PUE5_STANL/1-142 .MVSVSVESPEQTDLRLRRVIAEAEFVVHDGVWTFAETP--DPPVL.....TDEVLAVVRDTEVWSALVPASPE.lAGGERFGLFSFHFPGAPDNSGFVGWLAGHLKRELGTGVFVVCGSNTARGGIFDYWGSPAELLPQAVEVVERLRA-n.
A0A4R4XHZ7_9ACTN/1-144 .MVSVSMETAEQTEQRLRRVITQADLVVHDGVWCFEESPADQPPAL.....TPETLAVVRDQESWSRLAPLTQQ.gDGIERFGIFSFHFADQADNSGFVGWLATHLKTELGTGVFVVCGSNRARGGIYDYWGCPIDLLDQAIAVVETLRA-h.
A0A4S4ZK59_9ACTN/1-142 .MVTISHETPEETRLRLRRVLAEATLDVLPGRWSYHEHPAGAVPQP.....SVDALALVRDEECWSILEPSRG-..GEAEVFGAFSIHFPTADDNSGFVGWLAGELKDRFGTGVAVLCGYNSAQGGIYDYWLVPAPLLDEAVAHVRSLAA-a.
A0A2R4SVP7_9ACTN/1-144 .MVSVSMETAEQTEQRLRREIAQADLVVHDGVWCFEESPADQPPTL.....TAETLAVVRDRESWSRLVPLTQE.gDDVERFGIFSFHFADHVDNSGFVGWLATHLKVELGTGVFVVCGSNRARGGIYDYWGCPIDLLDQAIAVVRTLRD-s.
A0A8T4HLP6_9ACTN/1-142 .MVNISHETDQEVRGRLRRVLAEATFKELPGRWAYHEHPAGEPPQP.....STDALALVRDEEGWSVLEPARG-..DEAEVFGVFAFHFPAAADNSGFVGWLAGELKSRLGTGVAVLCGYNSAQGGIYDYWLVPAQLTDEAVAQVRRLAA-g.
A0A1S8FIE5_9BURK/1-149 .MMDVTPESPEQTRKRLLRVMAHARVDLLPGGYTFVEFPLAQFPAHlvtntACEALALVRDHAVWSALVPASAS.tKAEDRYVVACLHFAPDIPNSGFVGWLASEFKQQLGTGVFVICGHHAADGGVFDYWGIPESVAQQAVSLIHAMQA-r.
A0A0B6S3B3_BURPL/1-143 .MVDISHETAERTEQRLRRVITEARLVVYPGSYRFDEFPLDRFPAA....aRADALALVRDDQVWSQLVPGEE-..AGHERFGVFRFHFPEGADNSGFVGWLATHLKRRFGTGVFVTCGQNSAAGGIFDYWGVPAELAQPVFAEVGRLV--rg
A0A1M5FM80_STRHI/1-144 .MVSVSVETPRQTEERLRHVIAQADLVAHEGVWCFEEFPADEPPVL.....TGDTLAVVRDDESWSRLVPLTSE.sGDVERFGIFSFHFPGELDNSGFVGWLAGELKTRLGTGVFVICGSNRSRGGVYDYWGCPIKLFDAAIEVVQELRA-g.
A0A944E8R0_9ACTN/1-142 .MVSISHETPQETRTRLRRVLAGAVFKVLPGHWAYHEHSAGPMPQP.....SADALALVRDEEGWSILEPAQG-..DEAEVFGVFSFHFPAAAENSGFVGWLAGELKDHLGTGVAVLCGYNSAQGGIYDYWLVPAQLLGEAVAHVRSLAA-q.
A0AA41TZB6_9ACTN/1-144 .MVSVSVETAEQTEQRLRRVIAQADLVVHDGIWCFEESPADQPPAL.....TRETLAVVRDSESWSHLVPFRQQ.dGGVERFGIFSFHFTDQMDNSGFVGWLATRLKVELGTGVLVVCGSNRTRGGIYDYWGCPIDLVDKAIAVVEALRA-g.
A0A1H0B3Z0_9ACTN/1-144 .MVSVSRETSTQTRTRLRTVIANSEIVVFDGAWSFVETPMDQPPHL.....DERVLAVVRDDECWSALRPDDGS.dGDRERFGLLSFHFPPGLDNSGFVGWLATELKERLGTGLFVVCGSNSDRGGIYDYWGCPLDLLDDVVGVIRELA--dp
A0A3A1TV94_9MICO/1-145 .MVSVSHETPDETRTRLRGVLGLAEMVVLPGTWSFFESPRDRPPVL.....DEDLLAVVRDETSWSVLRPADEDgeDGRERFGVFSFHFPDGVDNSGFVGWLASALKEELGTGVFVVCGSNGDRGGVYDYWGCPRELLDDAVSAVHRLA--ia
A0A6N7EX52_9GAMM/1-143 .MVQISHETTEQTENRLRKVISETDFKVYAGAYAFEEFPLAKFNDK....vNQNALCLIRDEEVWSQLIPSDD-..QSKELFQIFSFHFDECKDNSGFIGWLANHLKARLGTGLFVTCGQNTNRDGIFDYWGCPLALGDKAVAEVQKLIE-d.
#=GC seq_cons .MVslShETsEQT-pRLR+VIApA-LsVa-GsWsFcEhPhspsPsh.....os-sLAlVRDc-sWStLVPssp...sssERFGlFSFHFPsshDNSGFVGWLAocLKpcLGTGVFVlCGpNpuRGGIYDYWGCPlsLhcpAlulVcpLRt.s.
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