GenomeNet

Database: Pfam
Entry: DUF6229
LinkDB: DUF6229
Original site: DUF6229 
#=GF ID   DUF6229
#=GF AC   PF19740.2
#=GF DE   Family of unknown function (DUF6229)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   52.50 52.30;
#=GF NC   22.80 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   21609846
#=GF RT   Identification and characterization of the lysobactin
#=GF RT   biosynthetic gene cluster reveals mechanistic insights into an
#=GF RT   unusual termination module architecture.
#=GF RA   Hou J, Robbel L, Marahiel MA;
#=GF RL   Chem Biol. 2011;18:655-664.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000385) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, NRP (non-ribosomal
#=GF CC   peptide). It  includes a member from the lysobactin biosynthetic
#=GF CC   gene cluster  from Lysobacter sp. ATCC 53042 [1]. This family
#=GF CC   appears to be  predominantly found in bacteria.
#=GF SQ   50
#=GS A0A2P2GU24_9ACTN/3-64   AC A0A2P2GU24.1
#=GS A0A099CX73_9GAMM/1-64   AC A0A099CX73.1
#=GS A0A099CX62_9GAMM/1-62   AC A0A099CX62.1
#=GS A0A1I6MDG2_9GAMM/1-67   AC A0A1I6MDG2.1
#=GS A0A1I6K8B6_9GAMM/1-60   AC A0A1I6K8B6.1
#=GS A0A427CG28_9GAMM/1-68   AC A0A427CG28.1
#=GS A0A257FIQ5_9BURK/10-68  AC A0A257FIQ5.1
#=GS A0A372P8Y3_9ACTN/5-61   AC A0A372P8Y3.1
#=GS A0A1W2AAM8_KIBAR/6-62   AC A0A1W2AAM8.1
#=GS A0A495X991_9PSEU/6-63   AC A0A495X991.1
#=GS C7PW58_CATAD/7-64       AC C7PW58.1
#=GS A0A4R3YTX6_9GAMM/1-62   AC A0A4R3YTX6.1
#=GS A0A0M9YC49_9ACTN/5-66   AC A0A0M9YC49.1
#=GS A0A0Q9F0C9_9GAMM/1-60   AC A0A0Q9F0C9.1
#=GS A0A2M9J4C0_9ACTN/6-66   AC A0A2M9J4C0.1
#=GS A0A5Q0H495_SACSY/6-63   AC A0A5Q0H495.1
#=GS A0A0S2DNQ3_LYSEN/1-65   AC A0A0S2DNQ3.1
#=GS A0A1K1MPE4_9GAMM/1-62   AC A0A1K1MPE4.1
#=GS A0A101NQQ8_9ACTN/5-66   AC A0A101NQQ8.1
#=GS A0A1Q5KGP2_9ACTN/1-61   AC A0A1Q5KGP2.1
#=GS K0K3E8_SACES/6-63       AC K0K3E8.1
#=GS A0A2T4VI46_9DELT/3-64   AC A0A2T4VI46.1
#=GS A0A369USC6_9GAMM/1-67   AC A0A369USC6.1
#=GS A0A0S2FCB6_9GAMM/14-74  AC A0A0S2FCB6.1
#=GS A0A4R6YT54_9GAMM/1-64   AC A0A4R6YT54.1
#=GS A0A516SIC7_9BURK/1-62   AC A0A516SIC7.1
#=GS A0A0T6LQ97_9ACTN/6-67   AC A0A0T6LQ97.1
#=GS A0A559UBI2_9ACTN/5-66   AC A0A559UBI2.1
#=GS A0A2X0KEC8_9ACTN/6-67   AC A0A2X0KEC8.1
#=GS A0A372P915_9ACTN/10-68  AC A0A372P915.1
#=GS A0A250VW17_STROL/6-66   AC A0A250VW17.1
#=GS A0A4R3CVJ3_9ACTN/5-66   AC A0A4R3CVJ3.1
#=GS G0FTA4_AMYMS/1-61       AC G0FTA4.1
#=GS A0A2N7QUA7_9GAMM/1-71   AC A0A2N7QUA7.1
#=GS A0A1T3NP75_9ACTN/6-67   AC A0A1T3NP75.1
#=GS A0A0S2DGV8_LYSEN/1-60   AC A0A0S2DGV8.1
#=GS A0A429BGZ2_9ACTN/5-62   AC A0A429BGZ2.1
#=GS H8MVS9_CORCM/4-65       AC H8MVS9.1
#=GS A0A3D9M8B3_9ACTN/6-67   AC A0A3D9M8B3.1
#=GS A0A6H9UTW1_9ACTN/1-61   AC A0A6H9UTW1.1
#=GS A0A563ESI1_9PSEU/6-65   AC A0A563ESI1.1
#=GS A0A1Z1WS22_9ACTN/3-66   AC A0A1Z1WS22.1
#=GS A0A516RJL2_STRST/4-65   AC A0A516RJL2.1
#=GS A0A1H6DU76_9ACTN/34-91  AC A0A1H6DU76.1
#=GS A0A0H1AL16_9GAMM/4-68   AC A0A0H1AL16.1
#=GS A0A1C6RCB4_9ACTN/10-70  AC A0A1C6RCB4.1
#=GS A0A432MAW0_9GAMM/4-62   AC A0A432MAW0.1
#=GS A0A367F9G1_9ACTN/1-59   AC A0A367F9G1.1
#=GS A0A510TFH4_9ACTN/5-66   AC A0A510TFH4.1
#=GS A0A0S2DBZ1_LYSEN/1-69   AC A0A0S2DBZ1.1
A0A2P2GU24_9ACTN/3-64              ......tt--RTDDIVTAWLQGAETAFGADNPAGPLYV.GGAAGEAALTDGTEALL......TGC.S....SCTGS...WHSYCC...
A0A099CX73_9GAMM/1-64              ........MSNAESIVTSWLQGDTAAGGKGNPAGSLFT.---VSNVDLKAVGNTREygvlntGPL.-....RCDTI...VAQYCF...
A0A099CX62_9GAMM/1-62              .msnenpi-----DTAAQWREEA----GVNNPAGPLFA.GDGFVESDIAGEASVIT.....lNGCgT....ACTGS...YTRYCC...
A0A1I6MDG2_9GAMM/1-67              ........MQQTDDIVSGWLSGSDSIDGMENPAGPLYIeGAAATEAALTGSTAGMNm....fTSA.Tt..vSCGGF...GGCDCC...
A0A1I6K8B6_9GAMM/1-60              .....men----ADRIAQLRNEAD----EHNPAGPLFT.GGQFAEAEIISEASSLTt....fGGCgT....ACTGS...HTRYCC...
A0A427CG28_9GAMM/1-68              ........MQLNDDVVSGWLNGADSVDGCDNPAGSLFIyGQQATEAALTSAAPVMAtg..gtGHCtT....TLSQI...GTCHCC...
A0A257FIQ5_9BURK/10-68             ......es--EAAALVAQWRSQAD----GSNPAGPLFI.GGEYAEADIVGDTSTIS......GKCgT....ACSGS...RTRMCC...
A0A372P8Y3_9ACTN/5-61              .......l-DRSEEIVSAWRSGAD-VEGWDSPAGPLFI.-GEYAESEITLTALD--......TRLaS....SCTCS...R--FCC...
A0A1W2AAM8_KIBAR/6-62              .......l-ADAEELVARWREGLD----LDSPAGPIFA.SGEFAEGDIVACNPPG-......SRC.S....SCTAS...RPVFCC...
A0A495X991_9PSEU/6-63              .......l-ESAEELVARWRAGLD---DVDNPAGPLFA.NGEFAEGDIVACNPPG-......SRC.S....SCTAS...RPVYCC...
C7PW58_CATAD/7-64                  .......l-DRTDAILSGWLGSTE-----DSPAGPLFT.GGKYAEADIVGAVVILT.....rGTC.S....SCTAS...RGGECC...
A0A4R3YTX6_9GAMM/1-62              .......m--QTDNILAGWLSGADSVDGYDNPAGSLYTeGHANTMAAMTSPDIALA......SNC.S....SCTAS...RPGFCC...
A0A0M9YC49_9ACTN/5-66              ....svpa----SAVLNAWLSGAESAYGQLNPAGPLYV.GGAAAEAALTDSSDSLY......GFC.S....SPSGS...HGSWCC...
A0A0Q9F0C9_9GAMM/1-60              .......m--QSNDIVSAWLTGANSADGYMNPAGPLFI.EGEVAVDDAMRSPLTHS......TSI.S....TC-PS...GRCYCC...
A0A2M9J4C0_9ACTN/6-66              .....vpa----STVLNAWLSGAESAYGQLNPAGPLYV.GGAAAEAGLTDSSDSLY......GFC.S....SPSGS...HGSWCC...
A0A5Q0H495_SACSY/6-63              ......ll--DAEELVARWRAGLD---ELDNPAGPLFA.NGEFAEGDIVACNPPG-......SRC.S....SCTAS...AHVYCC...
A0A0S2DNQ3_LYSEN/1-65              .......m--QNDDHVSDWLNGADSVDGLSNPAGPLYIeGAAATEDALTSPNEANM.....fSTR.T....AITCI...GAACC-fca
A0A1K1MPE4_9GAMM/1-62              .......m--QTDKILAGWLSGADNVGGYDNPAGPLYTeGHNQTLMAMTSTDIALI......SNC.S....SCTAS...RPGVCC...
A0A101NQQ8_9ACTN/5-66              ....sapt----TAVLDAWLSGAESAYGRLNPAGPLYV.GGTAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
A0A1Q5KGP2_9ACTN/1-61              ......mr---TAAVLEAWLSGAETAYGELNPAGPLYV.GGTAAEAALTDPSDSLY......GFC.S....SPSGS...RGSWCC...
K0K3E8_SACES/6-63                  ......ll--DAEEMVARWRAGLD---ESDNPAGPLFA.NGEFAEGDIVACNPPG-......SRC.S....SCTAS...RPVYCC...
A0A2T4VI46_9DELT/3-64              ......ds--RIDEILTGWLSGSESAFGMNNPAGPLYI.GGEATEAALTNSTDALY......TGC.S....SCTGS...LHSYCC...
A0A369USC6_9GAMM/1-67              ........MQQTDDIVSGWLSGSDSIDGMENPAGPLYIeGAAATEAALTSSTAGMNm....fTSA.Tt..vSCGGF...GGCDCC...
A0A0S2FCB6_9GAMM/14-74             ........MQQIDDIVSGWLSGAE--GGMENPAGPLYIeGMSATEAALTDSSLPLF......TRC.S....SCSAS...SGGQCC...
A0A4R6YT54_9GAMM/1-64              ........MQQHDEVVSGWLNGSNSVEGLDSPAGPLYL.--DNADSVLMSSENTIFft.glgGTT.A....SCRPS...S-CACC...
A0A516SIC7_9BURK/1-62              ....mdni--EAANLVEMWRNEA----GDSNPAGALYV.SGEYAEADIAMSIRPLT.....wGGCgT....ACSGS...SRYMCC...
A0A0T6LQ97_9ACTN/6-67              .......l-AETKDIVSGWRAGAESVGAFDNPAGPLYV.GGAATEAGLTRPDVAAV......TGL.S....PCTGS...GPIDCC...
A0A559UBI2_9ACTN/5-66              ......sv--QTAAVLEAWLSGAESAYGQLNPAGPLYV.GGAAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
A0A2X0KEC8_9ACTN/6-67              ......aa--HPGRIVDAWLAGAETAFGKDNPAGPLFV.GGGAAEAALTDSTDALM......AFC.S....SPTGS...YHSYCC...
A0A372P915_9ACTN/10-68             .......l-ERSEEIVSAWRSGAD-VEGWDSPAGPLFI.-GEYAESEITLTALD--......TRRpS....SCTGA...NTIPCC...
A0A250VW17_STROL/6-66              .....vat----TAVLDAWLTGAESAYGQTNPAGPLYV.GGAAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
A0A4R3CVJ3_9ACTN/5-66              .....rvs---TAAVLDAWLSGAESAFGQANPAGPLYV.GGTAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
G0FTA4_AMYMS/1-61                  .....mds----TAVLEGWLSGSESVHGLANPAGPLYV.GGNAAEAALVDPTDMLY......AFC.S....SPTGS...HGSWCC...
A0A2N7QUA7_9GAMM/1-71              ......mq---FDDIVSSWLNGEDSFGGHANPAGPLYIqGAGATEAALTSDKTVKSmltsigTTC.S....TCSIHssgGGCACC...
A0A1T3NP75_9ACTN/6-67              ......na--TRNTVVDAWRSGAETTDGMENPAGSLYI.GGSATEQGLTEIDVAAI......SCG.T....ACSWS...RTRACC...
A0A0S2DGV8_LYSEN/1-60              .......m--QSNDLVSGWLTGAETVMGFDNPAGPLYL.EGENAVEDAARAPITHS......TSI.S....TCPTG...-RCYCC...
A0A429BGZ2_9ACTN/5-62              .......l-ERAEEIIAAWRAGDD----PDSPAGPLMP.-GMYVESEITMTGPGGS......GRCgT....ACSGS...RTYQCC...
H8MVS9_CORCM/4-65                  ......na--SVHDVVQGWLSGDEESHGMTNPAGPVFV.GGMRTEQALTESNLVEN......TGC.S....SCSAS...TTGFCC...
A0A3D9M8B3_9ACTN/6-67              ......it--RADEIVTAWLQGAETAFGADNPAGPLYV.GGAAGEAALTDGTEALL......TGC.S....SCTGS...LHSYCC...
A0A6H9UTW1_9ACTN/1-61              .......m--HTAAVLDAWLTGADTAYGLSNPAGPLYV.GGAAAEAALTDPSDSLY......GFC.S....SPTGS...RGSWCC...
A0A563ESI1_9PSEU/6-65              ......ll--KAEEIVAGWRSGLD-FGDMMNPAGPMFA.SGEFAEGDIVACNPPG-......SRC.S....ACTAS...RPVYCC...
A0A1Z1WS22_9ACTN/3-66              ..htsvpt----TAVLTAWLSGAESAYGQANPAGPLYV.GGTAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
A0A516RJL2_STRST/4-65              ....tsvq----SAVLEAWLSGAESAYGQANPAGPLYV.GGTAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
A0A1H6DU76_9ACTN/34-91             .......l-ERAEEIIAAWRTGDD----PDSPVGPLLP.-GMYVESEITMTGPGGS......GRCgT....ACSGS...RTYQCC...
A0A0H1AL16_9GAMM/4-68              lnhgeyef-----DQASEWREYA----GADNPAGALFL.GGEYAEADIAGGDVSLTvf..ncTNC.A....DCTGS...ITIVCR...
A0A1C6RCB4_9ACTN/10-70             ......pv--QAEEIITRWLTDT-SVDGWENPAGDLFT.GGEYALQEITMTISPPS......SNC.S....SCTGS...RPIACC...
A0A432MAW0_9GAMM/4-62              ......vl--EGEALVAQWRASAD----VDSPAGPLFI.GGKYAKADIVNSAESIT......TNFlC....TCGTA...IHDNCC...
A0A367F9G1_9ACTN/1-59              ........MEHAEEIIAAWRRGVASAEGWENPAGPPLI.-GEYTEEEITMSLIE--......TKRpS....SC-TA...GGGFCC...
A0A510TFH4_9ACTN/5-66              ......sv--HTAAVLEAWLSGAESAQGQINPAGPLYV.GGAAAEAALTDPSDSLY......GFC.S....SPSGS...HGSWCC...
A0A0S2DBZ1_LYSEN/1-69              ........MQQNDDVVSGWLNGSDSVDGQDNPAGSLFIeGQAAAEAAMTGTGMRAT.....lGACgTlggtSCSYN...GGCLCC...
#=GC seq_cons                      .......h..psscllsuWLuGA-os.GhsNPAGPLal.GGtsAEAslTssssshh......utC.S....SCouS...pssaCC...
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