#=GF ID   DUF6313
#=GF AC   PF19832.4
#=GF DE   Family of unknown function (DUF6313)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.80 25.80;
#=GF TC   27.80 27.20;
#=GF NC   25.70 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 81514348 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16766657
#=GF RT   Amplification of the entire kanamycin biosynthetic gene cluster
#=GF RT   during empirical  strain improvement of Streptomyces
#=GF RT   kanamyceticus.
#=GF RA   Yanai K, Murakami T, Bibb M;
#=GF RL   Proc Natl Acad Sci U S A. 2006;103:9661-9666.
#=GF DR   INTERPRO; IPR046280;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000703) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide, in particular
#=GF CC   the  kanamycin biosynthetic gene cluster from Streptomyces
#=GF CC   kanamyceticus [1]. 
#=GF SQ   25
#=GS A0A6G4VGN5_9ACTN/35-189  AC A0A6G4VGN5.1
#=GS A0A7K0C1J3_9ACTN/3-94    AC A0A7K0C1J3.1
#=GS A0A7K0C1M6_9ACTN/43-131  AC A0A7K0C1M6.1
#=GS A0A0X3V2R8_9ACTN/15-196  AC A0A0X3V2R8.1
#=GS A0A918J6P1_9ACTN/39-222  AC A0A918J6P1.1
#=GS A0A5N0UXS5_9PSEU/44-221  AC A0A5N0UXS5.1
#=GS A0A0M8WQ80_9ACTN/27-210  AC A0A0M8WQ80.1
#=GS A0A4V2ERX6_9PSEU/28-207  AC A0A4V2ERX6.1
#=GS A0A6G3Q9K1_9ACTN/18-103  AC A0A6G3Q9K1.1
#=GS A0A4R2JL37_9PSEU/37-214  AC A0A4R2JL37.1
#=GS A0A0H3DDR0_AMYMU/49-221  AC A0A0H3DDR0.1
#=GS A0A495X0W2_9PSEU/53-239  AC A0A495X0W2.1
#=GS A0A1H0SCQ7_9ACTN/33-131  AC A0A1H0SCQ7.1
#=GS A0A1M7HCQ3_9ACTN/1-102   AC A0A1M7HCQ3.1
#=GS A0A7K3A1Q3_9ACTN/8-191   AC A0A7K3A1Q3.1
#=GS A0A4Q6IKQ4_9ACTN/29-210  AC A0A4Q6IKQ4.1
#=GS A0A1C4MZH8_9ACTN/39-224  AC A0A1C4MZH8.1
#=GS A0A1D7VYA6_9ACTN/15-196  AC A0A1D7VYA6.1
#=GS A0A371QBZ1_STRIH/15-196  AC A0A371QBZ1.1
#=GS A0A550HH98_9ACTN/2-74    AC A0A550HH98.1
#=GS A0A1H0SD63_9ACTN/3-87    AC A0A1H0SD63.1
#=GS A0A545ASE8_9ACTN/52-153  AC A0A545ASE8.1
#=GS A0A2Z4VB65_9ACTN/15-196  AC A0A2Z4VB65.1
#=GS A0A1B2HPJ4_9PSEU/39-224  AC A0A1B2HPJ4.1
#=GS A0A0B5F162_STRA4/42-222  AC A0A0B5F162.1
A0A6G4VGN5_9ACTN/35-189             ......wlligaslwll----------AFGLLYVAGGV..FLGWRAAYEVLVGLTAP.......Gq.trHsA....F....A....Y....VL...SLSGWLLVPAIIGGAAGYFLGRQID.ARR.SLSKEEVR.ERVANPE..PPA..TP.EpdrdqglRIRSLAEL...EAEGGEGRR..FVEKYVAGPHARNREVAEEHWSTTV---------.------.-.---..--..-..-------------..----------svrcgq.............................
A0A7K0C1J3_9ACTN/3-94               elipllsdllyarcgft---------------------..-----------------.......-....-.-....-....-....-....--...-------------------------.---.--------.-------..---..--.-.......--------...-----VPDG..FVESYVKL-HDQDWHRAQDHWERVVRWVLDCREVeSRATSR.R.AMQ..QA..V..AASGAILHLTPLL..ARCPHCRA--grr................................
A0A7K0C1M6_9ACTN/43-131             ..............lst---RGIPVLLGYAALFTGNGF..LIGWRRAYDVSIGITSP.......A....D.T....SapvpA....W....FL...SVAGWLLVPGIVGAVAGYAVSNAIT.SRR.TRPLDELF.-------..---..--.-.......--------...---------..----------------------------------.------.-.---..--..-..-------------..----------ped................................
A0A0X3V2R8_9ACTN/15-196             .................VIDWGIPFSAVITVLYGLAAR..TTSPSAVYRTLTLIDAP.......E....H.V....L....L....W....IA...SVVGWLAVPAVIGGVAGHVIATRIQ.SVK.AMSTSALF.RRRGWGA..RLR..PP.S.......RIDYLGAY...FHGTLAEQE..FVDAFVRVAHRNDWNMAQDHWEVLIRDTMSTQQF.AKLDRH.E.CLR..QA..Q..DVTRIHARPPALV..GLCLVCVARK...................................
A0A918J6P1_9ACTN/39-222             ................f-IDWGIPIFLVIGFVWVFGAGrsEKGWSGIYRVFTLIDRP.......V....H.V....S....S....W....GA...SILGWLLVPALIGGVAGHVIAARMQ.RVK.EIATNQLF.QRRGLKR..RLK..PP.G.......RITFLESL...HLKSAEDQE..FLDRYVRRAHRGDWKKAQDHWEVLVRDVLCTVEL.AELDRN.E.ALE..SA..E..SVARAVMWVTGYQ..DKCLVCTAR-a..................................
A0A5N0UXS5_9PSEU/44-221             ..............vrg-----YYILAGFAALFLANAL..VIGGREAYDVSVQIDSP.......W...sT.G....V....P....A....LAlplSLSGWLVVTGFAGAVAGYVVSE---.---.-VSDNRNIrRMRGGADtrRIT..HI.P.......LLSRLQYR...KHGFEIPQL..FALRFA-LRHELDWRLAQDHWEIIVEKFLHAG--.-EPDRS.K.GPR..QV..MweAVLEASYVLDEMS..GRCPECAA--aq.................................
A0A0M8WQ80_9ACTN/27-210             ................f-IDWGIPIALLIGFVWVFGASrsEKGWSGIYRAFTLIDPP.......V....H.E....S....S....W....GA...SVLGWLLVPALIGGVAGHVIATRMQ.RVK.EIATNHLF.QQRGLAR..RLK..LP.G.......RITFLESL...HLKSAVDQE..FLDRYVRRAHRGDWKKAQDHWEILVRDVLCTVEL.AELDRT.E.ALE..SA..E..SFARAVMWLTGYQ..DKCLVCTAR-a..................................
A0A4V2ERX6_9PSEU/28-207             .............lmvq----GYLVLVPFALLFVITAA..VCGARNAYDVMLQIASP.......G...eV.G....Y....Q....W....LTvplSMGGWLIVPGFAGALAGIVVVE---.-VT.SNRRGRQA.DRPGGRA..RSG..EI.P.......RLNWLQYY...RHDHDIPDY..FALRFAQ-RHGSDWKLAQDHWEILIERFLTIEAF.D---RR.L.GARvvMA..Q..AVSAVAYFLHGLS..GKCPECA---kva................................
A0A6G3Q9K1_9ACTN/18-103             ............laggr-------------LLFVLNGV..RLGWAAAYEVLIGITSP.......A....K.AdpqwM....A....W....RL...SLAGWVTVLAFIGGTVGYLITVQIQ.TH-.--------.-------..---..--.-.......--------...---------..----------------------------------.------.-.---..--..-..-------------..----------qardflrydqalargrp..................
A0A4R2JL37_9PSEU/37-214             .............vrgy------YILAGFVALFGFNWV..FIGGQVAYNVTVQIDSP.......W....D.T...rI....P....L....LAlplSLSGWLVVTGFAGAVAGYVVTE---.-VT.DNRNVRAL.RGRSTTR..RIG..PI.P.......RLDRLQYS...RHGFEIPHY..FAIRFV-LRHDGSWKIAQDHWEIIVEKFLTARE-.--ADRT.R.GSK..QAmwE..AVLEAAYVLDGMS..GRCPRCGR--dt.................................
A0A0H3DDR0_AMYMU/49-221             ..............vrg-----YYILAAFAGLFTLNAV..VIGGRVAYDVSVQIASP.......W...eT.R....A....P....W....VAlplSISGWLVVTGFAGAVAGYVVSE---.-VT.DNRSLRRS.RGRAAGR..RIG..AI.P.......LLDRLQYG...RHGFEIP-N..YFGIRFALRHDGDWPTAQDHWEIVVEKFL-----.------.-.---..--..-..-------------..----------nagdargkgpkrvmweavleasyvldgmsgrcpec
A0A495X0W2_9PSEU/53-239             .............lvte----GYVVVLVFAGLYVVNGL..LLGWTHAYEVSALIASP.......W....D.V....P....A....G....V-...EAPSWSWVPALLLSIAGWLVVTGFAgAVAgYMVLNATT.NRRGLKG..SRVgpLPsG.......EIPRLADL...QYSRHGHDVppYFALRFALRHDSDWRRAQDHWERLVARFLHTDAF.DRGDGN.DgVMR..QA..-..-VTYTSYFLHGLS..GRCPEC----lmak...............................
A0A1H0SCQ7_9ACTN/33-131             ..............lll---RALPLLAVFLGLFALNGA..LIGWTDAYNVLVGIDSP.......A....D.V....S....PqlpaW....PL...SIVGWAAIPALVGGAVGYAVTAQIQ.THR.TQELTEI-.-------..---..--.-.......--------...---------..----------------------------------.------.-.---..--..-..-------------..----------ldelrrrstasvns.....................
A0A1M7HCQ3_9ACTN/1-102              ..............mlf---RGLPVLLALAVLYVVTGF..VVGWRDAYDVSLGIESP.......AetkaP.V....L....A....W....FL...SVAGWLVMPGVAGAVAGYVVSDSIA.SRR.SRSLSESF.PQMITKD..---..--.-.......--------...---------..----------------------------------.------.-.---..--..-..-------------..----------dlrdilrel..........................
A0A7K3A1Q3_9ACTN/8-191              ................f-IDWGVPIALLVGCVWVFGAGrsEKGWSGIYRVFTLIDRP.......A....H.M....L....S....W....GA...SVIGWLLVPALIGGVAGHVIATRMQ.RVK.DIATNHLF.QQRPLSR..RLK..LP.G.......RIAFLESL...HMKSAVDQE..FLDRYVRRAHAGDWKKAQDHWEVLVRDVLCTVEL.ADLDRT.E.ALT..SA..E..SFARAVMWMTAYQ..DKCLVCTAR-a..................................
A0A4Q6IKQ4_9ACTN/29-210             .................VIDWGVPLAAGAIAVYIYAAR..TTSPSHVYRAFTLIDAP.......D....R.F....A....L....W....LP...SIVGWLLVPAIIGGVAGHIIAQRIS.SVK.AISTEKLF.RQRTWGQ..RLK..PP.G.......LIPDLRTY...FHGSYAQQN..FVDAWVRIAHRNDWHRAQDHWEVFIRDMASTQQY.AHLDRH.E.CLR..QA..R..DTAHLTLVITAQT..GMCIVCERRR...................................
A0A1C4MZH8_9ACTN/39-224             .................VVDRAIPMALLLAALWFFAAR.yDGGGGEVYRVFTLLDKP.......V...gH.P....L....L....W....IA...SAIGWVAVPAIIGGAAGHVITQRID.RVK.KQPSNRLF.RRRGLKQ..RLT..PP.G.......VIDDLRPY...RYGTGSQQA..FVDAFVRVAHRNDWQRAQDHWEVYLRDTMSTQQY.ADLDRH.E.CLR..QA..R..NVALIALRVAALSgnGHCIVCDRRS...................................
A0A1D7VYA6_9ACTN/15-196             .................TIDWGLPFATGVTLLYVFAAR..AAGPGEVYRTFTLIDPP.......Q....H.T....L....L....W....LA...SVIGWLAVPAVIGGVAGHVIATRIQ.SVK.SISTSTLF.QRRGWAA..RLR..PP.S.......RIDYLGGY...FHGTLAEQV..FVDAFVRVAHRNDWVKAQDHWEVIIKDTMSTQQF.SKLDRH.E.CLR..QA..Q..DATLIHMRPAALV..GLCVVCVARK...................................
A0A371QBZ1_STRIH/15-196             .................IIDAGLPFAAVIILLYVFAVR..SASPSAVYRTFTLIDAP.......Q....H.T....L....L....W....LA...SVIGWLAVPAVIGGVAGHVIATRIQ.SVK.AISSSTLF.QRRGWGD..RLR..PP.S.......RIDYLGAY...FHGMLAEQD..FVDAFVRIAHRNDWVKAQDHWEVIIRDMMSTQEF.SKLDRH.E.CLR..QA..Q..DSTRIHMRPAALV..GLCVVCVARK...................................
A0A550HH98_9ACTN/2-74               ............ngarl---------------------..--GRAVAYEVLIRITSP.......AkvgpQ.R....L....A....W....PL...SLAGWAAIPAFIGGTVDHLITVQIQ.TH-.--------.-------..---..--.-.......--------...---------..----------------------------------.------.-.---..--..-..-------------..----------qardflpydralar.....................
A0A1H0SD63_9ACTN/3-87               ......llseihecggp---------------------..-----------------.......-....-.-....-....-....-....--...-------------------------.---.--------.-------..---..--.-.......--------...------SAE..FVQHFAAKWHDGDWETAEDHWQRIVNRLLRGREM.EGLKPH.D.ALR..TA..E..QEAQNFG------..----------lalllspsptrcpmcai..................
A0A545ASE8_9ACTN/52-153             ..............llf---RGLPVLVALAVLYVVTGF..VVGWRDAYDVSLGIESP.......AatsaP.V....L....A....W....FL...SVAGWLVMPGVAGAVAGYVVSDSIG.SRR.SRSLNESF.PQ-----..---..--.-.......--------...---------..----------------------------------.------.-.---..--..-..-------------..----------iskddlreilreld.....................
A0A2Z4VB65_9ACTN/15-196             .................IVDWGLPMAVCLVLLYVFAAR..AGSPSSVYRVFTLIDAP.......K....H.V....L....L....W....LA...SLVGWLLVPAIIGGFAGHVIAERIS.RVK.SISTNTLF.QRRTLRQ..RVR..LP.G.......LIDDLGPY...FHGTHARQD..FVDTWVRVAHRNDWVKAQDHWEVFVRDTMSTQQY.AHLDRH.E.CLR..QA..Q..NTGKLALGFTARA..GLCIVCERRR...................................
A0A1B2HPJ4_9PSEU/39-224             ...............lv--TQGYLVLIVCAVLFCFNGF..VLGWDKAYEISALISSPwdvaaesR....H.A....W....V....WfpalLL...SIAGWLVVTGFAGAVAGYMVI---N.ATS.NRSPGSKG.DRLGPL-..---..PT.G.......NIPRLASLqysRHGHEIPPY..FALR-FAMRHEGDWRQAQDHWERMVMHFLRTDGF.DGGDGPgS.VMR..QA..-..-VTYTSYFLHGLS..GRCPEC----hgp................................
A0A0B5F162_STRA4/42-222             .................VIDWGVLILVVVAAVWVAAGF..AWGWAPAYRVFTLIESP.......V....H.G....L....P....W....AA...SVIGWLLVPAIIGGVAGHVIATRIR.SVK.EISPNNLF.KKRTWAD..RRR..LP.S.......LITKLGAL...FHKS-EQQQ..FLDAYVRIAHRGDWPEAQDHWEIVVRDALCTAEF.ADLDRT.E.ALR..LA..E..SLCRELAWLLALS..GRCLVCEARH...................................
#=GC seq_cons                       ................h....Gh.lhhshshLalhsuh..hhGhsssYcVhshI-uP.......t....c.s....h....s....W....hh...SlsGWLlVPAllGuVAGaVlupphp.ps+.shs.sphh.pphshtt..p.t.....s.......hls.Lt.h...hht....p...FhttasthtHcsDW.hAQDHWEhhlcchhps.th.tthctp.c.shc..pA.....ths.h.hh..sh...shC..C.......................................
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