GenomeNet

Database: Pfam
Entry: DUF6355
LinkDB: DUF6355
Original site: DUF6355 
#=GF ID   DUF6355
#=GF AC   PF19882.2
#=GF DE   Family of unknown function (DUF6355)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   26.60 26.60;
#=GF TC   29.70 27.30;
#=GF NC   25.90 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   29019409
#=GF RT   Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster
#=GF RT   Direct the Production of Totopotensamides.
#=GF RA   Chen R, Zhang Q, Tan B, Zheng L, Li H, Zhu Y, Zhang C;
#=GF RL   Org Lett. 2017;19:5697-5700.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001807) is described by MIBiG as an example
#=GF CC   of the following biosynthetic classes, NRP (non-ribosomal
#=GF CC   peptide) and polyketide, in particular the totopotensamide A
#=GF CC   biosynthetic gene  cluster from Streptomyces pactum [1]. This
#=GF CC   family appears to be  predominantly present in Actinobacteria.
#=GF SQ   109
#=GS A0A495X8A7_9PSEU/32-110  AC A0A495X8A7.1
#=GS A0A1G9CTT4_9ACTN/31-98   AC A0A1G9CTT4.1
#=GS A0A022MJ82_9ACTN/64-129  AC A0A022MJ82.1
#=GS A0A5Q0H3C5_SACSY/97-167  AC A0A5Q0H3C5.1
#=GS A0A5S4FJT8_9ACTN/57-118  AC A0A5S4FJT8.1
#=GS A0A1H3RZI9_9PSEU/31-92   AC A0A1H3RZI9.1
#=GS A0A1H0VTZ4_9PSEU/43-107  AC A0A1H0VTZ4.1
#=GS A0A1G6VV39_9PSEU/10-86   AC A0A1G6VV39.1
#=GS A0A4R4TIC2_9ACTN/29-92   AC A0A4R4TIC2.1
#=GS A0A6I5C5B8_9ACTN/35-104  AC A0A6I5C5B8.1
#=GS A0A1Q5JYT7_9ACTN/31-92   AC A0A1Q5JYT7.1
#=GS A0A291Q763_9ACTN/35-96   AC A0A291Q763.1
#=GS K0JUW7_SACES/30-108      AC K0JUW7.1
#=GS A0A1G9SHG6_9PSEU/55-118  AC A0A1G9SHG6.1
#=GS A0A1V6MNW5_9ACTN/35-97   AC A0A1V6MNW5.1
#=GS A0A6I6SIN2_9ACTN/50-115  AC A0A6I6SIN2.1
#=GS A0A0N7F2N6_9PSEU/44-105  AC A0A0N7F2N6.1
#=GS A0A0N9HSQ9_9PSEU/11-75   AC A0A0N9HSQ9.1
#=GS M3C7P3_STRMB/41-106      AC M3C7P3.1
#=GS A0A445N7Z7_STRNE/32-94   AC A0A445N7Z7.1
#=GS A0A2S4Z7R5_9ACTN/34-96   AC A0A2S4Z7R5.1
#=GS S3ZGJ4_9ACTN/34-96       AC S3ZGJ4.1
#=GS A0A1Z2LE37_9ACTN/50-115  AC A0A1Z2LE37.1
#=GS A0A1G9W8W1_9PSEU/34-100  AC A0A1G9W8W1.1
#=GS A0A1H8YNR0_9PSEU/43-106  AC A0A1H8YNR0.1
#=GS A0A5Q4T4W0_9ACTN/44-105  AC A0A5Q4T4W0.1
#=GS A0A505D5H7_9ACTN/33-94   AC A0A505D5H7.1
#=GS A0A0Q9A3N9_9ACTN/35-97   AC A0A0Q9A3N9.1
#=GS A0A1V4A0Y0_9ACTN/33-94   AC A0A1V4A0Y0.1
#=GS A0A0H5CIZ4_9PSEU/38-118  AC A0A0H5CIZ4.1
#=GS A0A161LI32_9ACTN/38-101  AC A0A161LI32.1
#=GS A0A1D7VX32_9ACTN/36-101  AC A0A1D7VX32.1
#=GS A0A2D3U3F3_STRC0/29-91   AC A0A2D3U3F3.1
#=GS A0A3N6F6S5_9ACTN/51-120  AC A0A3N6F6S5.1
#=GS A0A100Y3H5_9ACTN/40-104  AC A0A100Y3H5.1
#=GS A0A0N1GNE2_9ACTN/35-97   AC A0A0N1GNE2.1
#=GS A0A0C5FKR5_9ACTN/31-92   AC A0A0C5FKR5.1
#=GS A0A6H0CWU5_9ACTN/42-106  AC A0A6H0CWU5.1
#=GS A0A0K2B5K1_STRA7/50-119  AC A0A0K2B5K1.1
#=GS A0A1B1MN75_STRLN/32-94   AC A0A1B1MN75.1
#=GS A0A1U9ZVL1_9ACTN/29-93   AC A0A1U9ZVL1.1
#=GS A0A1W2FU59_KIBAR/36-102  AC A0A1W2FU59.1
#=GS A0A1Q5LAH6_9ACTN/14-77   AC A0A1Q5LAH6.1
#=GS A0A5Q0H154_SACSY/40-118  AC A0A5Q0H154.1
#=GS D2BAB6_STRRD/26-94       AC D2BAB6.1
#=GS A0A1A5P9S5_9ACTN/34-95   AC A0A1A5P9S5.1
#=GS A0A1M5MCY5_STRHI/44-112  AC A0A1M5MCY5.1
#=GS A0A558CTD7_9PSEU/51-114  AC A0A558CTD7.1
#=GS A0A1G9SKN0_9PSEU/67-127  AC A0A1G9SKN0.1
#=GS K4REK3_STRDJ/38-100      AC K4REK3.1
#=GS A0A1W2FSZ8_9PSEU/32-100  AC A0A1W2FSZ8.1
#=GS A0A4Q9HL89_STRKA/30-95   AC A0A4Q9HL89.1
#=GS V6JL86_STRNV/33-94       AC V6JL86.1
#=GS A0A4R7HQR8_9ACTN/34-96   AC A0A4R7HQR8.1
#=GS A0A6G2VVE5_9ACTN/34-96   AC A0A6G2VVE5.1
#=GS A0A6B2SIA6_9ACTN/35-96   AC A0A6B2SIA6.1
#=GS A0A2P8Q0X4_9ACTN/36-101  AC A0A2P8Q0X4.1
#=GS A0A0P0SDQ8_9PSEU/40-106  AC A0A0P0SDQ8.1
#=GS A0A1H5JR05_9ACTN/33-95   AC A0A1H5JR05.1
#=GS A0A1G9SAE9_9PSEU/33-107  AC A0A1G9SAE9.1
#=GS A0A1Q4YL66_9PSEU/82-149  AC A0A1Q4YL66.1
#=GS A0A1M6BMK0_9ACTN/35-97   AC A0A1M6BMK0.1
#=GS A0A0M8V5G9_9ACTN/35-96   AC A0A0M8V5G9.1
#=GS A0A2S9PTX6_9ACTN/29-91   AC A0A2S9PTX6.1
#=GS C7MEK4_BRAFD/31-116      AC C7MEK4.1
#=GS A0A1Q4VW05_9ACTN/31-92   AC A0A1Q4VW05.1
#=GS H2JPM0_STRHJ/34-96       AC H2JPM0.1
#=GS A0A1I2EIG1_9ACTN/41-105  AC A0A1I2EIG1.1
#=GS A0A0X3W9M4_9ACTN/38-99   AC A0A0X3W9M4.1
#=GS A0A5N8W3Z3_9ACTN/36-97   AC A0A5N8W3Z3.1
#=GS A0A1Z1W9D4_9ACTN/28-90   AC A0A1Z1W9D4.1
#=GS A0A2S6GF35_9PSEU/43-106  AC A0A2S6GF35.1
#=GS A0A4R9EIY2_9ACTN/36-98   AC A0A4R9EIY2.1
#=GS A0A1E5PK03_9ACTN/43-105  AC A0A1E5PK03.1
#=GS A0A366DVE8_9NOCA/3-64    AC A0A366DVE8.1
#=GS A0A495X6E2_9PSEU/31-109  AC A0A495X6E2.1
#=GS A0A516RHG8_STRST/34-96   AC A0A516RHG8.1
#=GS A0A6I4N5Y5_9ACTN/36-98   AC A0A6I4N5Y5.1
#=GS A0A5J6HKN8_STRAD/37-99   AC A0A5J6HKN8.1
#=GS A0A419HES5_9PSEU/21-87   AC A0A419HES5.1
#=GS A0A0W7WXV4_9ACTN/34-96   AC A0A0W7WXV4.1
#=GS A0A1H9C2E9_9ACTN/35-97   AC A0A1H9C2E9.1
#=GS A0A3N4UJS9_9ACTN/34-96   AC A0A3N4UJS9.1
#=GS A0A4R6SCU9_9PSEU/34-98   AC A0A4R6SCU9.1
#=GS A0A1W2FVD3_KIBAR/21-82   AC A0A1W2FVD3.1
#=GS A0A1G9R956_9PSEU/32-94   AC A0A1G9R956.1
#=GS H5X653_9PSEU/52-115      AC H5X653.1
#=GS A0A5S4GWN9_9ACTN/40-102  AC A0A5S4GWN9.1
#=GS A0A1G9RNG5_9ACTN/38-101  AC A0A1G9RNG5.1
#=GS L7ET76_9ACTN/35-96       AC L7ET76.1
#=GS A0A1G9ZQY0_9PSEU/33-96   AC A0A1G9ZQY0.1
#=GS A0A1G9R939_9PSEU/28-88   AC A0A1G9R939.1
#=GS A0A1G9RS69_9PSEU/15-82   AC A0A1G9RS69.1
#=GS A0A0X3XHG0_9ACTN/34-96   AC A0A0X3XHG0.1
#=GS A0A2T0S708_9PSEU/39-118  AC A0A2T0S708.1
#=GS A0A117PEW9_9ACTN/34-96   AC A0A117PEW9.1
#=GS A0A2S4XNT5_9ACTN/31-92   AC A0A2S4XNT5.1
#=GS A0A0C2AGQ4_9ACTN/70-139  AC A0A0C2AGQ4.1
#=GS D2AW62_STRRD/55-117      AC D2AW62.1
#=GS A0A6I4MFJ9_9ACTN/29-98   AC A0A6I4MFJ9.1
#=GS A0A1V2QIM1_9PSEU/93-159  AC A0A1V2QIM1.1
#=GS A0A124I9J4_9ACTN/34-96   AC A0A124I9J4.1
#=GS A0A2A2YN61_9ACTN/34-96   AC A0A2A2YN61.1
#=GS A0A1H0LC35_9PSEU/43-123  AC A0A1H0LC35.1
#=GS A0A1Q9LKM8_9PSEU/28-104  AC A0A1Q9LKM8.1
#=GS A0A419HR38_9PSEU/46-107  AC A0A419HR38.1
#=GS A0A495X5Z2_9PSEU/32-104  AC A0A495X5Z2.1
#=GS A0A371Q6I5_9ACTN/31-93   AC A0A371Q6I5.1
#=GS A0A0M8TT62_9ACTN/34-96   AC A0A0M8TT62.1
A0A495X8A7_9PSEU/32-110             .....v-VCGYHHVNPdq..................neGAIAVYTHCA...DSF.....ILIHIDNSNGH...AYHRC....VSPwSSV.PFFRGDG......VTNAYYVpitpe.tmvingKRMC..........................
A0A1G9CTT4_9ACTN/31-98              ......APCGWQG---......................DGTQDYNHCG...TTN.....VMLTVEHVFGD...DDHFC....ARP.GMN.NINAGNSpyntwrTVYAYYDn..........gP---tnc.......................
A0A022MJ82_9ACTN/64-129             .....s-GCGWNNP-G......................TEHPFYEHCD..tRTN.....VWIQVTRMWPS..gDYHRC....VGP.GKT.VLDSN--......ATGAWYDsn........yqGGLC..........................
A0A5Q0H3C5_SACSY/97-167             .....a-SCGFFTDPS.....................dHYYAKYNHCG..wASS.....IKIRVSFWYGW...STRDI...wVGR.YVT.NLSTHWQlqgagmITNAWCI............-QNC..........................
A0A5S4FJT8_9ACTN/57-118             ....vr--CGAYVD--......................FTHLWYKHCG...DSY.....IEVEVDKIKGD...NVFIC....IGPwEHK.AIASLLF......YDNAWYT............GRSC..........................
A0A1H3RZI9_9PSEU/31-92              ....li--CGFHME--......................ADGPWYGHCDappRTD.....VVINVHQYLVG...DYRMC....VRP.GDH.KLKPL--......AINAWYI............GQLC..........................
A0A1H0VTZ4_9PSEU/43-107             .....l-ACGWDPDGP......................SGRAYYNHCG..gDSW.....VWIRVERHHGL..sGYDEC....VGP.GRT.YLGDAGI......IKFAWYK............GETC..........................
A0A1G6VV39_9PSEU/10-86              ......APCGFSVD-G......................VGNGTYVHCA...NTF.....VLVKGHWSGGS...TFTNC....FRP.WEI.GYYG--Pda.gqrVVKVYYV............----pvrpnlvtfpngtvgc..........
A0A4R4TIC2_9ACTN/29-92              ......QACGYWQT--......................SADAYYTHCDngsGSR.....VIINVDTVWAS...DYEKC....VGP.GDT.HLGSTSD......VRGAWYV............GRTC..........................
A0A6I5C5B8_9ACTN/35-104             .....s-GCGWNNP-G......................TEHPFYEHCD..tRTN.....VWIQVTRMWPS..gDYHRC....VGP.GKT.VLDSN--......ATGAWYDsn........yqGGLCahpg......................
A0A1Q5JYT7_9ACTN/31-92              .....d-PCGFYET--......................GSDAYYNHCTs.dGSH.....VVIEVEV-WGP...NYEQC....VGP.GRT.WLGSASK......IDGAFYT............GRTC..........................
A0A291Q763_9ACTN/35-96              .....d-PCGYFAT--......................ASDAYYNHCTs.dGSH.....IVIEIDD-WGP...NSEQC....VGP.GVT.WIGSASD......VSGAWYT............GRLC..........................
K0JUW7_SACES/30-108                 .....s-ACGFHHVNPth..................nnGAVSRYDHCA...GSF.....ILIRVDTSSGY...RFGKC....VSPwGSV.PFYPREG......VTNAYYVpvapn.tmdvdgRRVC..........................
A0A1G9SHG6_9PSEU/55-118             ......EKCGFDPKGT.....................pAVQAWYNHCG...SGN.....VRIRIDRFIGD...NTFQC....VGP.GLT.LLGVWPD......FYDAWYD............NRTC..........................
A0A1V6MNW5_9ACTN/35-97              .....d-PCGFYET--......................GSDAYYNHCTs.dGSR.....VIVKVEVAWAP...DYERC....VAP.GKT.WLGSAGE......IQGAYYT............GRTC..........................
A0A6I6SIN2_9ACTN/50-115             ....lg--CGWNESRG......................GERAYYEHCA..tNTN.....VWIQVKRWPRS...DYHRC....VGP.GRT.NLDLD--......ATGAWYDst........yrGGLC..........................
A0A0N7F2N6_9PSEU/44-105             ......EPCGYYTA--......................GLNAYYNNCG...TTS.....VRIKIDRKPPK..pDEDRC....LSP.GNH.NLGPAQD......IIRLVFV............GTGC..........................
A0A0N9HSQ9_9PSEU/11-75              .....l-ACGWDPDAA......................KNVAYYNHCA..sSGN.....VVIRVEQHHGN..pGFDRC....VGP.RRT.PLGSLSD......IRYAWYK............GKTC..........................
M3C7P3_STRMB/41-106                 .....q-GCGWNESRG......................GERAYYEHCA..tNTN.....VWIQVTRFPRS...NYHRC....VGP.GRT.NLDFD--......ATGAWYDsg........yrGGLC..........................
A0A445N7Z7_STRNE/32-94              .....n-PCGFYET--......................GSDAFYNHCTg.dGSR.....VVIKVDVAWGP...DHERC....VAP.GTV.WLGSADK......INGAHYV............GRTC..........................
A0A2S4Z7R5_9ACTN/34-96              .....d-PCGFYET--......................SADAYYNHCTs.dGSR.....VVIKVEAAWAD...DYERC....VAP.GRT.WLGSASG......IQGAHYV............GRTC..........................
S3ZGJ4_9ACTN/34-96                  ......APCGFYET--......................SSDAYYNHCTs.dGSR.....VVIHVRVALAP...DYERC....VGP.GVT.WLGSDEK......IQGAHYV............GRTC..........................
A0A1Z2LE37_9ACTN/50-115             .....a-GCGWNASKG......................GERAYYEHCA..tNTN.....VWIQVKRFPRS...NYHRC....AGP.GRT.NLDAD--......ATGAWYDsn........yrGGLC..........................
A0A1G9W8W1_9PSEU/34-100             .....e-RCGAYIVLQt...................sgGHMLKYKNCS...DYA.....VRIEIDMRYEP...NRFEC....MRP.WEN.RLVEWYQ.....iADNAWYT............DTLC..........................
A0A1H8YNR0_9PSEU/43-106             ......EPCGYLG---......................--DGTYRHCDggtGST.....VMLDVQDLWGS...IYHYC....VGP.GVT.DLQPVIRw....rIRDAWWN............G---yvgc......................
A0A5Q4T4W0_9ACTN/44-105             .....k-ACGYYET--......................QTDAYYGHCG...STW.....VKIQVDIDWWP..tDIKRC....VPP.GET.HLGTTDG......IDNAWAI............EGTC..........................
A0A505D5H7_9ACTN/33-94              ......NPCGFYET--......................GSDAYYNHCTg.dGSR.....VVIEVEV-WGP...NYERC....VGP.GVS.WLGSASK......IDGAHYV............GRTC..........................
A0A0Q9A3N9_9ACTN/35-97              .....d-PCGFYKT--......................SSDAYYNHCTs.dGSR.....VVVKVEVALAP...DYERC....VGP.GTT.WLGPAGK......IQGAYYV............GRLC..........................
A0A1V4A0Y0_9ACTN/33-94              ......EPCGYYST--......................GSYAYYNHCG...RTT.....VQIKLDIVRGK...DKTIC....VRP.GTT.GLGPKNH......VRSAAYT...........gGAGC..........................
A0A0H5CIZ4_9PSEU/38-118             .....w-KCGFYITPGd...................shGTTSRYFHCG...YNH.....IMIQVHWSNGA...SHIGC....IEP.WEN.HPF---WrdgatvVVNAYFVpvtprvlispsgRRVC..........................
A0A161LI32_9ACTN/38-101             ....yg--CGYIHFTEt....................pDRRAKYNHCG..pNST.....VQIMVENSFWW...D----....---.---.-------......-------............----cgpytvnrgitdieawcggirtlyaw
A0A1D7VX32_9ACTN/36-101             .....n-ACGWNEGAG......................GEHAFYEHCA..tDTN.....VWIQVTRWARG...KYHRC....VGP.GRT.VLDYD--......ATGAWYDsn........yrGGLC..........................
A0A2D3U3F3_STRC0/29-91              ......KPCGYSES--......................GAFAWYNHCTt.dGSR.....IQIRLDAVAGF...DTNRC....VDP.GET.RLGWAFE......YRNAWYT............GRLC..........................
A0A3N6F6S5_9ACTN/51-120             ......AQCGFFRYSVr....................eSQFAAYNHCG...ETT.....VRIHVDVRGGGsgnDFHLC....VGP.GAT.QLPGAGP.....nYLNAYYI...........gGAGC..........................
A0A100Y3H5_9ACTN/40-104             .....l-ACGWDPDAA......................SGRAYYNHCTs.dGSW.....IWIRVERHGAS...GFDKC....VGP.NRT.YLGSTSV......IRYAWYK............GGTC..........................
A0A0N1GNE2_9ACTN/35-97              .....n-PCGFYET--......................GSDAYYNHCTs.dGSR.....VVIKVEVAWAA...DYERC....VGP.GTS.WLGSAAK......IQGAHYT............GRTC..........................
A0A0C5FKR5_9ACTN/31-92              .....d-PCGFYKT--......................GSDAFYNHCTs.dGSN.....VVIEVEV-RGP...NYERC....VGP.GRS.WLGSSGR......INGAFYT............GRTC..........................
A0A6H0CWU5_9ACTN/42-106             .....t-ACGWRTD-W......................TGHAYYNHCG...TGN.....VVIFVDRLNIGgirDYEQC....VTP.GDH.YLGDWPD......FQGAWYA............GKTC..........................
A0A0K2B5K1_STRA7/50-119             ......APCGFFRYSVr....................eSQFAGYGHCG...ETT.....VLVHVDVRGGGstnDYHLC....VGP.GAT.QLPGAGP.....nYLNAYYI...........gGAGC..........................
A0A1B1MN75_STRLN/32-94              .....d-PCGFFET--......................GSDAFYNHCTs.dGSR.....VVIKVEVALAP...DYERC....VGP.GKH.WLGSASK......IQGAYYV............GRTC..........................
A0A1U9ZVL1_9ACTN/29-93              .....a-RCGAYLTGEa....................wGADLRYYHCG...DTR.....IFIEIDNISGP...NQYTC....VDPwEDK.YIAERQT......ADNAWYI............-GLC..........................
A0A1W2FU59_KIBAR/36-102             .....y-DCGFIEGYKt....................pGGRAWYNHCG...ESP.....VKIIVENIWFT...DKEKC....VPV.GIT.DIEYYVDg...wkTRDAWAV............G---sc........................
A0A1Q5LAH6_9ACTN/14-77              .....r-KCGYYED--......................AVTAWYNHCTs.dGSH.....IWVYIDRAWPY..gDVERC....LGP.GIT.DIGGARE......VNNAWYS............GRLC..........................
A0A5Q0H154_SACSY/40-118             .....e-GCGFRHVNPdh..................hgGATALYIHCA...DSF.....ILIRVDTADGS...-RHQC....VDPwGSV.RFYPNMH......VSNAYYV............----pipprlltasdgslic..........
D2BAB6_STRRD/26-94                  .....p-RCGFFINQVr....................eTRFAVYGHCG...PTT.....VLVHVDVSGGGstnDYHLC....VGP.GNT.LLGYYGN......ILNAYYI...........gGAGC..........................
A0A1A5P9S5_9ACTN/34-95              ......NPCGFYET--......................HSDAYYNHCTs.dGSR.....IVIEIDD-WGP...NSERC....VGP.GVT.WIGSSSD......VDGAWYT............GRTC..........................
A0A1M5MCY5_STRHI/44-112             ......SPCGFYKS--......................NSDAFYHHCG...DTW.....VWVEIQPAGSA..dSYEIC....VAPwWEG.WLGTARE......ITNAWYTrva......vreG---ggc.......................
A0A558CTD7_9PSEU/51-114             .....e-VCGFYPV--......................---GMYRHCDngsGST.....VMLDVRDIFWG...IHHVC....VGP.GVT.NLQPGIRw....rVIGAWWN...........gGVGC..........................
A0A1G9SKN0_9PSEU/67-127             .....h-PCGFFGL--......................ETYAYYNHCG...SGN.....VLIHIDRIWPA..sDGEEC....VRP.GYT.PIGVLLF......TKNAHYI............-RPC..........................
K4REK3_STRDJ/38-100                 .....d-PCGFFET--......................GSDAFYNHCTs.dGSN.....VVIKVEVSLAP...DYERC....VGP.GKS.WLGSASK......IQGAYYT............GRTC..........................
A0A1W2FSZ8_9PSEU/32-100             ......AACGFWKD--......................SPKAYYTHCTs.dGSK.....IWIRVDVRGGE...WWDEC....VPP.GTT.RLEADFWgmdpgrVTNAYYK............GILC..........................
A0A4Q9HL89_STRKA/30-95              .....n-GCGWNGGSS......................GKHPFYEHCA..tNTN.....VWIKVKRFPRG...NYHRC....VGP.GKT.VLDID--......ATGAWYDsg........yrGGLC..........................
V6JL86_STRNV/33-94                  .....t-PCGYYSS--......................SSDSYYNHCTn.dGSR.....VVIEVEV-SGW...NYEQC....VGP.GVT.WLGSKSK......VSDAWYV............GRTC..........................
A0A4R7HQR8_9ACTN/34-96              .....d-PCGFYET--......................SSDAYYNHCTs.dGSR.....VVIKVEVAWGS...DYERC....VAP.GKT.WLGSADK......IQGAHYV............NRTC..........................
A0A6G2VVE5_9ACTN/34-96              .....d-PCGFYET--......................GSDAYYNHCTs.dGSH.....VVIKVEVALAP...DYERC....VAP.GRT.WLGSAAK......IQGAHYV............GRTC..........................
A0A6B2SIA6_9ACTN/35-96              ......NPCGFYET--......................HSDAYYNHCTs.dGSR.....IVIEIDD-WGP...NSERC....VGP.GVT.WIGSASG......VDGAWYT............GRTC..........................
A0A2P8Q0X4_9ACTN/36-101             ......QACGYYET--......................QTDAYYNHCV...NNPppgvgARLQVDYDWTP..fDGYEC....VRP.GET.HLGSTSD......IDNAWYL............-STC..........................
A0A0P0SDQ8_9PSEU/40-106             ......AKCGYSTLENd...................ttNNKANYLNCS...PGN.....ERIRVEYTYA-...TEEKC....VTP.GDT.PLFANPDl...gaVRNAVPI............-GTC..........................
A0A1H5JR05_9ACTN/33-95              .....g-PCGFYKT--......................STDAYYRHCTr.dGSH.....VVIKVKVARAR...DHEAC....VRP.GTT.WLGSARR......IQGAYYV............GRTC..........................
A0A1G9SAE9_9PSEU/33-107             ......APCGYDESTPvgq................pehRRDAKYHHCG...DHTv...sVQIQVDLATQP...DYTFCtqriLTP.HWY.YLGSANA......VNHAWYT............GRLC..........................
A0A1Q4YL66_9PSEU/82-149             .....y-ACGWSAP--......................NRNSYYNHCG...YGR.....IQVNVEFWWGVg.aTRTIC....VGH.GVT.TLSTHPQlq.gglITYAYYN............GRGC..........................
A0A1M6BMK0_9ACTN/35-97              .....n-PCGFYET--......................GSDAFYNHCTs.dGSH.....VVIKVEVALAP...DYEWC....VGP.GTT.WLGSSRK......IQGAHYT............GRTC..........................
A0A0M8V5G9_9ACTN/35-96              ......NPCGFYET--......................GSDAYYNHCTg.dGSR.....IIIEVEV-FGP...NYEKC....VAP.GDT.WLGSASK......IDGAFYT............GRLC..........................
A0A2S9PTX6_9ACTN/29-91              ......KPCGYSES--......................GGRAWYNHCTs.dGSR.....IQIRLDAVAGL...DTNRC....VDP.GET.VLGWAFE......YRNAYYT............GRLC..........................
C7MEK4_BRAFD/31-116                 ....le--CGYSEVQEkynsslaislpwvgtvdpfggtRMVAHWGNCG...DQN.....QKIRIDTKNGP...-KDLC....VTP.GDT.RLGFSRNd...qkVTGAV--............----klggc.....................
A0A1Q4VW05_9ACTN/31-92              .....d-PCGFYET--......................SRDAYYHHCTs.dGSR.....VIIEVEV-FGP...NYERC....VGP.GVT.WLGSSGK......IDGAHYV............GRTC..........................
H2JPM0_STRHJ/34-96                  .....d-PCGFYET--......................GSDAYYNHCTs.dGSH.....VVIKVEVALAP...DYERC....VAP.GRT.WLGSATK......IQGAYYV............GRTC..........................
A0A1I2EIG1_9ACTN/41-105             .....s-ACGFWVN-A......................QGWAFYTHCTgsvYTI.....VQVKVVTRSGP...GSLIC....VRP.GTV.GLGPNSV......VSNAYYT............GRLC..........................
A0A0X3W9M4_9ACTN/38-99              ......NPCGFYET--......................ASDAYYNHCTs.dGSR.....IVIEIDD-WGP...NSTRC....VGP.GVT.WIGEAGD......IDGAWYV............GRTC..........................
A0A5N8W3Z3_9ACTN/36-97              ......NPCGFFET--......................SSDAYYNHCTt.dGSR.....IVIEIDD-WGP...NTLQC....VGP.GTT.WIGAAGD......IDGAWYT............GRTC..........................
A0A1Z1W9D4_9ACTN/28-90              .....d-PCGFYET--......................SSDAFYNHCTs.dGSR.....VVIHVRVALAP...DYERC....VGP.GKT.WLGSASK......IQGAHYV............NRTC..........................
A0A2S6GF35_9PSEU/43-106             .....d-PCGYWRAGNw...................lsGYTYWYRHCG...STY.....VWVHISYYDNT...YDSSC....FSP.WEK.R-QLSWR......TTNAYYT............-GLC..........................
A0A4R9EIY2_9ACTN/36-98              .....n-PCGFYET--......................GSDAFYNHCTs.dGSN.....VVIQVRVALAP...DYERC....VGP.GNH.WLGSASK......IQGAHYV............GRTC..........................
A0A1E5PK03_9ACTN/43-105             ......KPCGYSES--......................DRRAWYNHCTt.dGSR.....IQIRVDVVHGP...DFNTC....AEP.GVN.TLGWAFK......YRNAWYT............GKLC..........................
A0A366DVE8_9NOCA/3-64               mrkvve----------......................SDTAYYRHCG...DST.....VLVRVEYSWIVgggDHHFC....AGPwTVS.VLGHEAH......VDYAVAI............-ATC..........................
A0A495X6E2_9PSEU/31-109             .....a-SCGFHHVNPdh..................heGAVALYTHCA...DSF.....ILIRVDHSNGY...SYHRC....VVPwGSV.PFFRNEG......VTNAYYVpitpd.tmvvngQRLC..........................
A0A516RHG8_STRST/34-96              ......APCGFYET--......................SSDAYYQHCTs.dGSR.....VVIQVRVALAP...DYERC....VAP.GKT.WLGSADK......IQGAHYV............GRTC..........................
A0A6I4N5Y5_9ACTN/36-98              .....n-PCGFYET--......................GSDAFYNHCTs.dGSK.....VVIHVRVALAP...DYERC....VGP.GKS.WLGSASK......IQGAHYV............GRTC..........................
A0A5J6HKN8_STRAD/37-99              .....d-PCGFYET--......................HSDAYYNHCTs.dGSR.....VVIHVRVALAP...DYERC....VAP.GRT.WLGSASK......IQGAHYV............GRTC..........................
A0A419HES5_9PSEU/21-87              ......EACGFNAHGI......................GDHATYMHCN..qNTN.....VWVKIVR-TFD...DVTLC....VAP.GLT.DLDNWDTta..qwITNAYSN............GTTC..........................
A0A0W7WXV4_9ACTN/34-96              .....d-PCGFYET--......................ASDAFYNHCTs.dGSR.....VVIHVRVAMQA...DYERC....VGP.GKT.WLGSASK......IQGAHYT............GRTC..........................
A0A1H9C2E9_9ACTN/35-97              .....d-PCGFYET--......................GSDAYYNHCTs.dGSR.....VVIKVGVALAP...DYERC....VAP.GRT.WLGSAGR......IQSAHYA............GRTC..........................
A0A3N4UJS9_9ACTN/34-96              .....d-PCGFYET--......................SSDAYYNHCTs.dGSR.....VVIQVRVALAP...DYERC....VGP.GTT.WLGAADK......IQGAHYV............NRTC..........................
A0A4R6SCU9_9PSEU/34-98              .....q-TCGFYVS--......................SATAWYNHCG...TTN.....VLVRVDVAGGGsgnDYCAI....VHP.GLN.PLGASGQ......ILNAYYL...........sT---grc.......................
A0A1W2FVD3_KIBAR/21-82              ......APCGFYT---......................GINAYYNHCG...DNY.....VTIKVDHWDDR..nEWSYC....SAPwEDK.YLGPTNV......VSFAHFA............KAGC..........................
A0A1G9R956_9PSEU/32-94              ...gcg---GFRDA--......................GYGYYYDHCG...PTQ.....VKINIDVARRP...DQTRC....VNP.GDN.LLWLKVNg...peARGAWYV............-GLC..........................
H5X653_9PSEU/52-115                 .....e-ACGYLG---......................--FAKYRHCDggtGST.....VMLDVIDILGG...GHARC....VGP.GIS.DLQGGIRw....rVVDAYWN...........gGVGC..........................
A0A5S4GWN9_9ACTN/40-102             .....a-TCGWDPV--......................ANDAYYNHCN..sNVH.....VVIRVERHSGL..tGYDKC....VPP.GRT.YLGSMSV......IAYAHYI............GKTC..........................
A0A1G9RNG5_9ACTN/38-101             ......AACGWIG---......................GQGAQYNHCD..pSTT.....VMLDVEDIWGN...IGRVC....VSP.GIT.RLQPYFEw....aVTGAWFN...........gGVHC..........................
L7ET76_9ACTN/35-96                  ......NPCGYYAT--......................GSDAYYNHCTs.dGSH.....IVIEVEV-WGP...NYEKC....VLP.GVT.WLGSSSK......VDGAFYT............GRTC..........................
A0A1G9ZQY0_9PSEU/33-96              .....g-PCGHWSKDKv....................lWMEHYYTHCG...ATR.....VYVNVTDRGGI...RPSFC....IDP.GATeYLGTN--......VTYAHSD............GTRC..........................
A0A1G9R939_9PSEU/28-88              ...gcg---GYWND--......................ATYAYYTHCG...PTS.....VLIDVDVAWGA...DFTRC....VGPnSTT.NIGLWPR......TRNAWYV............-RPC..........................
A0A1G9RS69_9PSEU/15-82              .....t-KCGVYVDHDyp.................qpdGPQLMYNHCG...DTN.....VTITVDRIRGE...NFEKC....VPP.GIT.HIGQWPL......YHNAWYV............RNRC..........................
A0A0X3XHG0_9ACTN/34-96              .....d-PCGFYET--......................SSDAYYNHCTs.dGSR.....VVIQVRVAYAA...DYERC....VAP.GRT.WLGSAAK......IQGAHYV............GRTC..........................
A0A2T0S708_9PSEU/39-118             .....g-TCGFYFTNPd...................hnSATARYLHCG...NSF.....ILIQVDWSNGW...HQREC....VPP.-WY.SVPFYPDgp..hrVVNAYYVpvapd.liddgqHRIC..........................
A0A117PEW9_9ACTN/34-96              .....d-PCGFYET--......................SSDAYYNHCTs.dGSR.....VVIQVRVAHAP...DYERC....VAP.GRT.WLGSADK......IQGAHYV............GRTC..........................
A0A2S4XNT5_9ACTN/31-92              .....d-PCGFYKT--......................SSDAFYNHCTs.dGSH.....VVIEVEV-WGP...NYERC....VVP.GVT.WLGSADE......IDGAHYV............GRTC..........................
A0A0C2AGQ4_9ACTN/70-139             .....t-QCGFFRYSVr....................eSQFAGYNHCG...ETT.....VRVHVDVRGHGstnDYHLC....VNP.GRT.QLPGAGP.....nYLNVYYI...........gGAGC..........................
D2AW62_STRRD/55-117                 .....v-RCGFYED--......................RYTAWYNHCTs.dGSR.....IKIRVVRNYWP...DNTIC....VGP.GHT.DLGSPGV......VVNAWYT............GKLC..........................
A0A6I4MFJ9_9ACTN/29-98              .....p-PCGFFRYNVr....................aSEFAAYNHCG...STT.....VRIHVDVRGGGstnDYHLC....VSP.GRT.QFPGAGP.....nYLNAYYI...........gGAGC..........................
A0A1V2QIM1_9PSEU/93-159             .....g-DCGFYT---......................GRDAWYRHCK...NSW.....IIIRVNFWYGA...NYRDI...wVGPnSTT.NLSRHPDlqgaglITNAWCI............-RYC..........................
A0A124I9J4_9ACTN/34-96              .....d-PCGFYET--......................SSDAYYNHCTs.dGSR.....VVIQVRVAQAP...DYERC....VGP.GKT.WLGSADR......IQGAHYV............NRTC..........................
A0A2A2YN61_9ACTN/34-96              .....d-PCGFFET--......................SADAYYNHCTs.dGSR.....VVIKVEVALAP...DYERC....VAP.GKT.WLGSASK......IQGAYYI............GRTC..........................
A0A1H0LC35_9PSEU/43-123             .....l-PCGWFRTNHd...................paGTTSRYRHCA...NSF.....IMIRIHWSNGA...SHRLC....VEP.-WE.NIPFWRDgk..hiVTNAYYIpdrprviirpdgSRYC..........................
A0A1Q9LKM8_9PSEU/28-104             .....a-VCGFQV-GA......................GGRGIYTHCA...NTF.....VLVKGHWSNGA...TFTRC....FEP.WQSgSFGPGGGl....rVTQMYYV............----pvrpnlvvgpdgrtyc..........
A0A419HR38_9PSEU/46-107             ......EQCGYYTLGPv....................tARFSFYDHCG...DGR.....VIIKIVYYIGS...DEERC....VGP.GTS.NLGLG--......VSNAYYD............-RPC..........................
A0A495X5Z2_9PSEU/32-104             .....v-VCGYHHVNPdq..................neGAVAVYTHCA...DSFi...lILIHIDNSNGH...AYHRC....VSP.WST.-------......-------............----vpffrgdgvtfgasagpgttpc....
A0A371Q6I5_9ACTN/31-93              .....d-PCGFYKT--......................GSDAFYNHCTs.dGSR.....VVIKVKVAWGP...DYERC....VTP.GKT.WLGSAGK......IQGAHYV............GRTC..........................
A0A0M8TT62_9ACTN/34-96              .....d-PCGFYET--......................GSDAFYNHCTs.dGSQ.....VVIKVEVALAP...DYERC....VGP.GRS.WLGSASK......ISGAHYV............GRTC..........................
#=GC seq_cons                       .....t.sCGaaps........................uscAaYsHCs...sop.....VhIcV-shhus...saccC....VuP.GpT.hLGsssp......lpsAaYs............GpsC..........................
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